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https://www.readbyqxmd.com/read/29458171/toxicology-studies-of-furosine-in-vitro-in-vivo-and-exploration-of-the-related-mechanism
#1
Hui-Ying Li, Lei Xing, Jia-Qi Wang, Nan Zheng
AIM: Furosine is one of the Maillard reaction products (MRPs) and is found in a variety of heat-processed food. Yet its toxicity is still unclear. The present study was designed to assess furosine toxicity in cell models and in CD-1 mice, respectively. METHODS: In vitro, the effects of furosine on the cell viability, cell cycle and apoptosis (Hek293, HepG2, SK-N-SH and Caco2) were detected and evaluated, sensitive cell lines and proper dosage of furosine for further animal experiment were determined, and the mechanisms of toxicity were explored...
February 16, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29457904/conflict-in-the-mechanism-and-kinetics-of-the-barrierless-reaction-between-sh-and-no-2-radicals
#2
Ramanpreet Kaur, Vikas
There are some unsettled issues regarding the mechanism and kinetics of an important atmospheric reaction of NO2 radical with the SH radical. The existing mechanism is based on the formation of HSO and NO radicals, both of which can result only along one barrierless channel. However, the detection of NO radical has never been reported though the formation of HSO radical has been followed in some studies to determine the rate constants. The latter are mainly obtained by monitoring the SH decay, but rate constants are reported to be highly conflicting among the existing studies reporting its value ranging from 10-10 to 10-12 cm3 molecule-1 sec-1 ...
February 19, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29457719/fabrication-of-bsa-auncs-based-nanostructures-for-cell-fluoresce-imaging-and-target-drug-delivery
#3
Caifeng Ding, Yujuan Xu, Yanan Zhao, Hua Zhong, Xiliang Luo
Drug delivery which can offer efficient and localized drug transportation together with imaging capabilities is highly demanded in the development of cancer theranostic approaches. Herein, we report the construction of bovine serum albumin (BSA) gold nanoclusters (BSA@AuNCs) for cell fluoresce imaging and target drug delivery. BSA@AuNCs were modified with cyclic arginine-glycine-aspartate (cRGD) with the product RGD-BSA@AuNCs to enhance the cell internalization of the nanoclusters. Furthermore, doxorubicin (DOX), a widely used a chemotherapy drug, was also used to modify RGD-BSA@AuNCs...
February 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29456986/extract-from-teucrium-polium-l-protects-rat-heart-against-oxidative-stress-induced-by-ischemic-reperfusion-injury
#4
Maryam Mahmoudabady, Milad Haghshenas, Saeed Niazmand
Background: The deleterious effect of oxidative stress on myocardial ischemia-reperfusion (I/R) has already been shown in previous studies. Since Teucrium polium has anti-oxidative and cardio-protective properties, the aim of this study was to investigate the effects of this plant on I/R injuries in the isolated rat heart. Materials and Methods: The myocardial I/R injury of rat was created by Langendorff retrograde perfusion technology. The heart was preperfused with Krebs-Henseleit (K-H) solution containing T...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29455364/hyperirisinemia-is-independently-associated-with-subclinical-hypothyroidism-correlations-with-cardiometabolic-biomarkers-and-risk-factors
#5
Theodora Stratigou, Maria Dalamaga, Georgios Antonakos, Ioanna Marinou, Evaggelos Vogiatzakis, Gerasimos Socrates Christodoulatos, Irene Karampela, Athanasios G Papavassiliou
PURPOSE: Irisin, a newly discovered adipo-myokine, is implicated in the modulation of the adipose phenotype, increasing energy expenditure and ameliorating systemic metabolism. Our aim was to investigate circulating irisin in subclinical hypothyroidism (SH) and study its associations with cardiometabolic risk factors. METHODS: In a large case-control study, serum irisin, insulin resistance and lipid parameters, classic adipokines, inflammatory and hepatic biomarkers, and cardiovascular risk factors were determined in 120 consecutive patients with SH and 120 healthy controls matched on age, gender, and date of blood draw...
February 17, 2018: Endocrine
https://www.readbyqxmd.com/read/29454670/ultrasonography-and-detection-of-subclinical-joints-and-tendons-involvements-in-systemic-lupus-erythematosus-sle-patients-a-cross-sectional-multicenter-study
#6
Carine Salliot, Amélie Denis, Emmanuelle Dernis, Vincent Andre, Aleth Perdriger, Jean-David Albert, Saloua Mammou Mraghni, Isabelle Griffoul-Espitalier, Mohamed Hamidou, Benoit Le Goff, Sandrine Jousse Joulin, Thierry Marhadour, Christophe Richez, Nicolas Poursac, Estebaliz Lazaro, Stéphanie Rist, Anca Corondan, Clara Quinten, Virginie Martaillé, Antoine Valéry, Emilie Ducourau
OBJECTIVES: The aims of this study in SLE population were 1) to describe ultrasonography (US) joint abnormalities, 2) to estimate the reliability of clinical swollen joint count (C-SJC) and SLEDAI (C-SLEDAI) versus US-SJC and US-SLEDAI scores, 3) to highlight specific patterns of lupus patients with Power Doppler (PD) abnormalities. METHOD: For this cross-sectional multicenter study, 151 consecutive adult SLE patients were recruited. Evaluation included a clinical standardized joint assessment, B-mode and PD US of 40 joints and 26 tendons blinded for clinical examination...
February 15, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29454373/subclinical-hypothyroidism-in-children-is-it-always-subclinical
#7
R Gallizzi, C Crisafulli, T Aversa, G Salzano, F De Luca, M Valenzise, G Zirilli
Aim of this commentary is to report current knowledges on the main clinical and metabolic abnormalities which might be observed in children with longstanding and untreated subclinical hypothyroidism (SH) and to comment the most recent views about natural evolution of thyroid function in the cases with either idiopathic or Hashimoto's thyroiditis-related SH. On the basis of these preliminary remarks, the essential guidelines for an appropriate and tailored management of SH children are also proposed.
February 17, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29453779/mitochondrial-cytochrome-p450-cyp-1b1-is-responsible-for-melatonin-induced-apoptosis-in-neural-cancer-cells
#8
Zhenlong Yu, Xiangge Tian, Yuling Peng, Zheng Sun, Chao Wang, Ning Tang, Bin Li, Yuqing Jian, Wei Wang, Xiaokui Huo, Xiaochi Ma
Melatonin is an endogenous indoleamine with a wide range of biological functions in the various organisms from bacteria to mammals. Evidence indicates that melatonin facilitates apoptosis in cancer cells and enhances the anti-tumor activity of chemotherapy in animals and clinical studies. However, the melatonin metabolism and the key metabolic targets in cancer cells still remain unknown. In this study, U118 and SH-SY5Y tumor cell lines were used to investigate the metabolic pathways of melatonin in cancer cells...
February 17, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29451422/intraperitoneal-onlay-mesh-technique-for-spigelian-hernia-in-an-outpatient-and-short-stay-surgery-unit-whats-new-in-intraperitoneal-meshes
#9
María Carmen Fernández-Moreno, Elena Martí-Cuñat, Guillermo Pou, Joaquín Ortega
BACKGROUND: Spigelian hernia (SH) is a rare entity, but its surgical treatment is essential because of its high complication risk. Laparoscopic approaches have become the option in elective surgery because it has less morbidity and requires a shorter stay. Several laparoscopic techniques have been employed, but there is no gold standard technique for this kind of hernia. We report, in this study, our experience with intraperitoneal onlay mesh (IPOM) repair. MATERIALS AND METHODS: Fifteen patients underwent elective surgery for SH between 2008 and 2015 in a Short-Stay Surgical Unit...
February 16, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29451412/development-and-validation-of-a-radiomic-signature-to-predict-hpv-p16-status-from-standard-ct-imaging-a-multicenter-study
#10
Leijenaar Rth, Bogowicz M, Jochems A, Hoebers Fjp, Frederik Fwr, Huang Sh, Chan B, Waldron Jn, O'Sullivan B, Rietveld D, Leemans Cr, Brakenhoff Rh, Riesterer O, Tanadini-Lang S, Guckenberger M, Ikenberg K, Lambin P
OBJECTIVES: HPV positive oropharyngeal cancer (OPSCC) is biologically and clinically different from HPV negative OPSCC. Here, we evaluate the use of a radiomic approach to identify the HPV status of OPSCC. METHODS: Four independent cohorts, totaling 778 OPSCC patients with HPV determined by p16 were collected. We randomly assigned 80% of all data for model training (N=628) and 20% for validation (N=150). On the pre-treatment CT images, 902 radiomic features were calculated from the gross tumor volume (GTV)...
February 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29451183/the-level-of-twist1-expression-determines-the-response-of-colon-cancer-cells-to-mitogen-activated-protein-kinases-inhibitors
#11
Tomasz Przybyla, Martyna Wesserling, Monika Sakowicz-Burkiewicz, Izabela Maciejewska, Tadeusz Pawelczyk
Background/Aim: Currently, it has been proposed that combination of 5-fluorouracil (5FU) with inhibitors of the mitogen-activated protein kinases (MAPKs) signaling pathway might enhance the efficacy of 5FU-based chemotherapy in colon cancer. Our study aimed to investigate an impact of TWIST1 silencing on the sensitivity of cancer cells to 5FU and selected MAPK inhibitors. Materials and Methods: The suppression of TWIST1 expression in human colon cancer HT29 and HCT116 cell lines was achieved by transduction with lentiviral vector carrying the TWIST1 silencing sequence (pLL3...
January 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29450889/olive-olea-europaea-leaf-extract-alters-the-cytokine-profile-of-leishmania-major-infected-macrophages-new-insight-into-the-underlying-mechanism
#12
F Keirandish, N Mosaffa, M J Tarahi, Sh Fallahi
This study aimed to identify the effects of olive leaf extract (OLE) on IFNγ, TNFα, TGFβ, and nitric oxide (NO) resulted from macrophages infected with Leishmania major (L. major) amastigotes in the culture medium. High-performance liquid chromatography (HPLC) was used to analyze the level of Oleuropein in plant extract. To evaluate the immunomodulatory effects of OLE, the isolated BALB/c mice peritoneal macrophages were infected with L. major promastigotes and treated with 6.25, 12.5, and 25μg/mL concentrations of OLE...
February 16, 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29450721/analysis-of-changes-in-thermal-growing-season-indices-tgsi-and-their-relations-with-some-selected-atmospheric-teleconnection-patterns-atps-over-the-northwest-of-iran
#13
Ali Akbar Sabziparvar, Fatemeh Khoshhal Jahromi
The daily minimum air temperature data from 18 stations located in the northwest of Iran during the period 1986-2015 was used to analyse the inter-annual variations and trends of thermal growing season indices (tGSI) and their relations with different atmospheric teleconnection patterns (ATPs). To analyze the changes in tGSI, tGSS (thermal growing season start), tGSE (thermal growing season end), and tGSL, the time period between tGSS and tGSE were considered. Using non-parametric Mann-Kendall and Spearman tests, the existence of a significant trend for time series of the tGSI and the correlation between ATPs and tGSI was evaluated...
February 15, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29450115/plipastatin-a1-produced-by-a-marine-sediment-derived-bacillus-amyloliquefaciens-sh-b74-contributes-to-the-control-of-gray-mold-disease-in-tomato
#14
Zongwang Ma, Jiangchun Hu
Certain Bacillus species have the capacity to produce cyclic lipopeptides and these lipopeptides are promising determinants contributing to the biocontrol of plant diseases. In the current study, a cyclic lipopeptide plipastatin A1 was isolated from the fermentation broth of a marine sediment-derived Bacillus amyloliquefaciens SH-B74 by the combination of solid-phase extraction and reversed-phase high-performance liquid chromatography, and its structure was identified by tandem mass spectrometry, high-resolution electro-spray ionization mass spectrometry, and gas chromatography-mass spectrometry together with nuclear magnetic resonance analysis...
February 2018: 3 Biotech
https://www.readbyqxmd.com/read/29449807/atrial-natriuretic-peptide-acts-as-a-neuroprotective-agent-in-in-vitro-models-of-parkinson-s-disease-via-up-regulation-of-the-wnt-%C3%AE-catenin-pathway
#15
Arianna Colini Baldeschi, Eugenia Pittaluga, Federica Andreola, Simona Rossi, Mauro Cozzolino, Giuseppe Nicotera, Gianluca Sferrazza, Pasquale Pierimarchi, Annalucia Serafino
In the last decades increasing evidence indicated a crucial role of the Wnt/β-catenin signaling in development of midbrain dopaminergic (mDA) neurons. Recently dysregulation of this pathway has been proposed as a novel pathomechanism leading to Parkinson's disease (PD) and some of the molecules participating to the signaling have been evaluated as potential therapeutic targets for PD. Atrial natriuretic peptide (ANP) is a cardiac-derived hormone having a critical role in cardiovascular homeostasis. ANP and its receptors (NPRs) are widely expressed in mammalian central nervous system (CNS) where they could be implicated in the regulation of neural development, synaptic transmission and information processing, as well as in neuroprotection...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29448724/environmental-applications-of-nano-sized-recycled-aggregates-the-effect-of-sterilization-and-adsorption
#16
Hyung-Sun Yoon, Ik-Hyun Lim, Seong-Gyu Seo, Jeongdong Choi, Won-Chun Park, Eun-Sik Kim
To evaluate the sterilize efficiency of nano-sized recycled aggregates (RAs), several types of RAs were examined for the purpose of environmental stamping out procedure. The poultry (e.g., chicken) was selected as a target livestock of epidemic disease, and the blast furnace slag (BFS), fly ash (FA), slaked lime (SL), nano-cerium (n-Ce) and shell (Sh) were used as the RAs materials. The fermented solution of effective microorganisms (EM) was added to decompose the target livestock. Various kinds of lab-scale reactor were operated to examine the effects of RAs volume; high and low volume of RAs (e...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448096/ampk-alleviates-endoplasmic-reticulum-stress-by-inducing-the-er-chaperone-orp150-via-foxo1-to-protect-human-bronchial-cells-from-apoptosis
#17
Ji-Qiang Liu, Li Zhang, Ji Yao, Shuo Yao, Ting Yuan
Chronic obstructive pulmonary disease (COPD), is characterized by inflammation of airways accompanied by a progressive destruction of lung parenchyma. This process is initiated in most cases by cigarette smoking. In this study we investigated the role of AMP activated protein kinase (AMPK) in cigarette smoke extract (CSE)-induced airway epithelial cell apoptosis as a consequence of endoplasmic reticulum stress (ER stress). Exposure of human bronchial epithelial cells (HBEpC) to CSE resulted in apoptosis as detected using Annexin V-PI flow cytometry...
February 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29446867/epigallocatechin-gallate-reduces-amyloid-%C3%AE-induced-neurotoxicity-via-inhibiting-endoplasmic-reticulum-stress-mediated-apoptosis
#18
Ke Du, Mingyan Liu, Xin Zhong, Weifan Yao, Qinghuan Xiao, Quan Wen, Bo Yang, Minjie Wei
SCOPE: We investigated the role of endoplasmic reticulum (ER) stress in the protective effects of EGCG against the neuronal apoptosis in Aβ 1-42 -induced SH-SY5Y cells and APP/PS1 transgenic mice. METHODS AND RESULTS: Cell viability (CCK8 assay), flow cytometry, Hoechst 33258 staining, immunohistochemistry, Transmission Electron Microscopy (TEM), western blotting were used. EGCG prevented Aβ1-42-induced toxicity in SH-SY5Y cells, increased cell viability and decreased apoptosis in a dose-dependent manner...
February 15, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29446648/electromagnetic-field-could-protect-sh-sy5y-cells-against-cisplatin-cytotoxicity-but-not-mcf-7-cells
#19
Hamideh Mahmoudinasab, Mostafa Saadat
Cisplatin [cis-dichlorodiammine platinum (II), CDDP], morphine (Mor), and electromagnetic field (EMF) induced oxidative stress. In this study, we tried to increase the cytotoxicity of CDDP in combination with Mor and/or EMF in MCF-7 and SH-SY5Y cells. Furthermore, we evaluate the expression levels of 11 antioxidant genes in both cell lines. We designed four treatments: CDDP alone, "CDDP+Mor," "CDDP+EMF," and "CDDP+Mor+EMF." Serial dilutions of CDDP, Mor (5.0 μM), and EMF (50 Hz, 0...
February 15, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29445718/designing-and-developing-automatic-trolley-for-washing-and-dressing-the-wounds
#20
M S Golvardi Yazdi, M Naderizadeh, R Afzalipour, H A Abedi, M Radmehr, R Golvardi Yazdi, Sh Salari Pashaghi
Introduction: Many items are needed for dressing including sterile dressing set, antiseptic and washing solutions, leucoplast tape, waste bin for infectious garbage, waste bin for noninfectious garbage, safe disposal trash for sharp cutting instruments, bedpan and sometimes drugs. All the items are laid out on a simple wheeled trolley. The multiplicity of items together with problems in placing tools on trolley, forgetting some items, disturbing sterile condition, falling and damaging equipment and the need for at least two people for each procedure, all are the reasons to design and develop Automatic Trolley for Washing and Dressing the Wounds...
December 2017: Journal of Biomedical Physics & Engineering
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