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https://www.readbyqxmd.com/read/28350850/defective-bone-repair-in-mast-cell-deficient-cpa3cre-mice
#1
Jose Luis Ramirez-GarciaLuna, Daniel Chan, Robert Samberg, Mira Abou-Rjeili, Timothy H Wong, Ailian Li, Thorsten B Feyerabend, Hans-Reimer Rodewald, Janet E Henderson, Paul A Martineau
In the adult skeleton, cells of the immune system interact with those of the skeleton during all phases of bone repair to influence the outcome. Mast cells are immune cells best known for their pathologic role in allergy, and may be involved in chronic inflammatory and fibrotic disorders. Potential roles for mast cells in tissue homeostasis, vascularization and repair remain enigmatic. Previous studies in combined mast cell- and Kit-deficient KitW-sh/W-sh mice (KitW-sh) implicated mast cells in bone repair but KitW-sh mice suffer from additional Kit-dependent hematopoietic and non- hematopoietic deficiencies that could have confounded the outcome...
2017: PloS One
https://www.readbyqxmd.com/read/28350471/functionalized-molybdenum-disulphide-nanosheets-for-0d-2d-hybrid-nanostructure-photoinduced-charge-transfer-and-enhanced-photoresponse
#2
Razi Ahmad, Ritu Srivastava, Sushma Yadav, Dinesh Singh, Govind Gupta, Suresh Chand, Sameer Sapra
The high concentration stable dispersion of free standing mono- or few layer transition metal dichalcogenide (TMDs) nanosheets (NS) remains a significant barrier for their application in solution processed optoelectronic devices. Here, we report oleylamine (OLA) and dodecanethiol (DDT) assisted exfoliation of MoS2 NS in non-polar organic solvent 1,2 dichlorobenzene (DCB) which enable high concentration stable dispersion of free standing mono- or few layer nanosheets. During sonication the -NH2 or -SH group of OLA and DDT ligand, respectively, adsorb at the sulfur vacancy sites and edges...
March 28, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28346873/design-synthesis-docking-studies-and-biological-evaluation-of-novel-chalcone-derivatives-as-potential-histone-deacetylase-inhibitors
#3
Mamdouh F A Mohamed, Montaser Sh A Shaykoon, Mostafa H Abdelrahman, Bakheet E M Elsadek, Ahmed S Aboraia, Gamal El-Din A A Abuo-Rahma
A group of novel chalcone derivatives comprising hydroxamic acid or 2-aminobenzamide group as zinc binding groups (ZBG) were synthesized. The structure of the prepared compounds was fully characterized by IR, NMR and elemental microanalyses. Most of the tested compounds displayed strong to moderate HDAC inhibitory activity. Some of these compounds showed potent anti-proliferative activity against human HepG2, MCF-7 and HCT-116 cell lines. In particular, compounds 4a and 4b exhibited significant anti-proliferative activity against the three cell lines compared to SAHA as reference drug and displayed promising profile as anti-tumor candidates...
March 19, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28346830/synergetic-neuroprotective-effect-of-docosahexaenoic-acid-and-aspirin-in-sh-y5y-by-inhibiting-mir-21-and-activating-rxr%C3%AE-and-ppar%C3%AE
#4
Yongwang Fu, Jin Zhen, Zuneng Lu
Parkinson's disease (PD) is a serious neurodegenerative disorder that lacks effective therapeutic methods. In this research, expressions of PPARα, RXRα, and miR-21 were evaluated in PD patients and normal controls. To investigate the effects of miR-21, docosahexaenoic acid (DHA) and aspirin (ASA) on PD, as well as the relationships between them, SH-Y5Y cells were treated with DHA, ASA, or both for 24 h. The assay showed that levels of miR-21 were increased and levels of PPARα were decreased in PD patients compared with normal controls...
March 27, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28346551/infrared-spectra-of-hscs-c-hscs-and-hcs2-produced-on-electron-bombardment-of-cs2-in-solid-para-hydrogen
#5
Masashi Tsuge, Yuan-Pern Lee
We report infrared (IR) spectra of HSCS(+), c-HSCS, HCS2(-), and other species produced on electron bombardment of a mixture of CS2 and para-hydrogen (p-H2) during deposition at 3.2 K. After maintenance of the deposited matrix in darkness for 12 h, the intensities of the absorption lines of HSCS(+) at 2477.2 (ν1), 1525.6 (ν2), and 919.6 cm(-1) (ν3) decreased through neutralization of HSCS(+) with trapped electrons. During this period, the intensities of the lines of HCS2(-) at 2875.7 (ν1), 1249.9 (ν5), 1003...
March 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28345598/novel-1-4-dihydropyridines-for-l-type-calcium-channel-as-antagonists-for-cadmium-toxicity
#6
Madhu Sudhana Saddala, Ramesh Kandimalla, Pradeepkiran Jangampalli Adi, Sainath Sri Bhashyam, Usha Rani Asupatri
The present study, we design and synthesize the novel dihydropyridine derivatives, i.e., 3 (a-e) and 5 (a-e) and evaluated, anticonvulsant activity. Initially due to the lacuna of LCC, we modeled the protein through modeller 9.15v and evaluated through servers. Docking studies were performed with the synthesized compounds and resulted two best compounds, i.e., 5a, 5e showed the best binding energies. The activity of intracellular Ca(2+) measurements was performed on two cell lines: A7r5 (rat aortic smooth muscle cells) and SH-SY5Y (human neuroblastoma cells)...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28344490/comparison-of-physicochemical-properties-of-suppositories-containing-starch-hydrolysates
#7
Piotr Belniak, Katarzyna Świąder, Michał Szumiło, Aleksandra Hyla, Ewa Poleszak
The purpose of this work was to determine the effect of starch hydrolysates (SH) on the physicochemical properties of suppositories. The study was conducted with suppositories with acetaminophen (AAP) a typical antipyretic analgesic, as model drug on lipophilic (cocoa butter) and hydrophilic base (polyethylene glycol 1500 + 400). The suppositories with and without the addition of SH were examined for physicochemical tests according to European Pharmacopoeia 8th edition (Ph. Eur.): the uniformity of mass of single-dose preparation test, the softening time determination of lipophilic suppositories test, the disintegration of suppositories test, and dissolution test with flow-through apparatus...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28343994/revelation-of-the-dynamic-progression-of-hypoxia-reoxygenation-injury-by-visualization-of-the-lysosomal-hydrogen-peroxide
#8
Yuanjun Zhu, Tongliang Zhou, Lingfei Yang, Lan Yuan, Lei Liang, Ping Xu
Hydrogen peroxide (H2O2) plays an important role in pathological conditions, such as cerebral ischemia-reperfusion (I-R) injury. Fluorescent probes may serve as valuable tools to detect the amount, temporal and spatial distribution of H2O2 in living cells. To investigate the role of lysosomal H2O2 involved in cerebral I-R injury, we designed and synthesized a lysosome-targetable two-photon fluorescent probe ztl-4, through expansion and substitution of the original pyridazinone scaffold, conjugation of electronic-donating aromatic ring and precise terminal modification of the alkyl linker...
March 24, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28343128/peroxy-titanium-complex-based-inks-for-low-temperature-compliant-anatase-thin-films
#9
N S Shabanov, A Sh Asvarov, A Chiolerio, K Sh Rabadanov, A B Isaev, F F Orudzhev, S Sh Makhmudov
Stable highly crystalline titanium dioxide colloids are of paramount importance for the establishment of a solution-processable library of materials that could help in bringing the advantages of digital printing to the world of photocatalysis and solar energy conversion. Nano-sized titanium dioxide in the anatase phase was synthesized by means of hydrothermal methods and treated with hydrogen peroxide to form Peroxy-Titanium Complexes (PTCs). The influence of hydrogen peroxide on the structural, optical and rheological properties of titanium dioxide and its colloidal solutions were assessed and a practical demonstration of a low temperature compliant digitally printed anatase thin film given...
March 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28342715/prediction-of-neonatal-respiratory-morbidity-by-quantitative-ultrasound-lung-texture-analysis-a-multicenter-study
#10
Montse Palacio, Elisenda Bonet-Carne, Teresa Cobo, Alvaro Perez-Moreno, Joan Sabrià, Jute Richter, Marian Kacerovsky, Bo Jacobsson, Raúl A García-Posada, Fernando Bugatto, Ramon Santisteve, Àngels Vives, Mauro Parra-Cordero, Edgar Hernandez-Andrade, José Luis Bartha, Pilar Carretero-Lucena, Kai Lit Tan, Rogelio Cruz-Martínez, Minke Burke, Suseela Vavilala, Igor Iruretagoyena, Juan Luis Delgado, Mauro Schenone, Josep Vilanova, Francesc Botet, George Sh Yeo, Jon Hyett, Jan Deprest, Roberto Romero, Eduard Gratacos
BACKGROUND: Prediction of neonatal respiratory morbidity may be useful to plan delivery in complicated pregnancies. The limited predictive performance of the current diagnostic tests together with the risks of an invasive procedure, limit the use of fetal lung maturity assessment. OBJECTIVE: To evaluate the performance of quantitative ultrasound texture analysis (quantusFLM®) to predict neonatal respiratory morbidity in preterm and early-term (<39.0 weeks) deliveries ...
March 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28342314/electrochemical-dna-sandwich-biosensor-based-on-enzyme-amplified-microrna-21-detection-and-gold-nanoparticles
#11
Jihane Mandli, Hasna Mohammadi, Aziz Amine
In this work, a novel electrochemical biosensor for miRNA-21 determination, involving a sandwich hybridization assay onto gold nanoparticles modified pencil graphite electrode (PGE) and enzyme signal amplification was reported. The thiol terminated capture probe 1 (SH-P1) was immobilized on the electrode through AuS interaction. In the presence of target miRNA-21, SH-P1 hybridized with the first part of the target, however, the second part hybridizes with a biotinylated probe P2 (B-P2). Then, a streptavidin-conjugated alkaline phosphatase was immobilized by a specific binding of avidin-B-P2...
March 14, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28342135/pacap-protects-against-ethanol-and-nicotine-toxicity-in-sh-sy5y-cells-implications-for-drinking-smoking-co-morbidity
#12
Sridharan Manavalan, Bruk Getachew, Kebreten F Manaye, Syed J Khundmiri, Antonei B Csoka, Raechel McKinley, Andrea Tamas, Dora Reglodi, Yousef Tizabi
The detrimental effects of heavy drinking and smoking are multiplied when the two are combined. Treatment modalities for each and especially for the combination are very limited. Although in low concentration, alcohol and nicotine, each may have beneficial effects including neuroprotection, their combination, instead of providing additive protection, may actually lead to toxicity in cell cultures. Pituitary adenylate cyclase-activating polypeptide (PACAP) is an endogenous 38 amino-acid peptide with demonstrated protection against neuronal injury, trauma as well as various endogenous and exogenous toxic agents...
March 24, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28341846/risk-factors-of-post-operative-severe-hyperlactatemia-and-lactic-acidosis-following-laparoscopic-resection-for-pheochromocytoma
#13
Shubin Wu, Weiyun Chen, Le Shen, Li Xu, Afang Zhu, Yuguang Huang
Severe hyperlactatemia (SH)/lactic acidosis (LA) after laparoscopic resection of pheochromocytoma is an infrequently reported complication. The study aims to investigate the incidence of this complication and to determine the clinical risk factors. Patients who underwent laparoscopic resection for pheochromocytoma between 2011 and 2014 at Peking Union Medical College Hospital were enrolled. LA was defined as pH < 7.35, bicarbonate <20 mmol/L, and serum lactate ≥5 mmol/L; SH as lactate ≥5 mmol/L; and moderate hyperlactatemia (MH) as lactate 2...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341201/the-atm-kinase-inhibitor-ku-55933-provides-neuroprotection-against-hydrogen-peroxide-induced-cell-damage-via-a-%C3%AE-h2ax-p-p53-caspase-3-independent-mechanism-inhibition-of-calpain-and-cathepsin-d
#14
Jakub Chwastek, Danuta Jantas, Władysław Lasoń
The role of the kinase ataxia-telangiectasia mutated (ATM), a well-known protein engaged in DNA damage repair, in the regulation of neuronal responses to oxidative stress remains unexplored. Thus, the neuroprotective efficacy of KU-55933, a potent inhibitor of ATM, against cell damage evoked by oxidative stress (hydrogen peroxide, H2O2) has been studied in human neuroblastoma SH-SY5Y cells and compared with the efficacy of this agent in models of doxorubicin (Dox)- and staurosporine (St)-evoked cell death. KU-55933 inhibited the cell death induced by H2O2 or Dox but not by St in undifferentiated (UN-) and retinoic acid-differentiated (RA)-SH-SY5Y cells, with a more pronounced effect in the latter cell phenotype...
March 21, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28340706/layer-by-layer-self-assembly-of-gold-nanoparticles-thiols-%C3%AE-cyclodextrin-coating-as-the-stationary-phase-for-enhanced-chiral-differentiation-in-open-tubular-capillary-electrochromatography
#15
Lin-Lin Fang, Ping Wang, Xiao-Li Wen, Xin Guo, Lin-da Luo, Jia Yu, Xing-Jie Guo
The popularity of capillary electrochromatography (CEC) has led to an increasing number of studies on the development and evaluation of enantioselective CEC systems. Herein, a novel, simple, and economical method for the preparation of chiral stationary phases for enantioselective open tubular capillary electrochromatography (OTCEC) was reported for the first time. This novel capillary column was fabricated through layer-by-layer self-assembly of GNPs on a 3-mercaptopropyl-trimethoxysilane (MPTMS)-modified fused-silica capillary and subsequent surface functionalization of the GNPs through self-assembly of thiols β-cyclodextrin (SH-β-CD)...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28338582/validation-of-the-clinician-graded-electronic-facial-paralysis-assessment-the-eface
#16
Lauren Sh Chong, Timothy J Eviston, Tsu-Hui Hubert Low, Shaheen Hasmat, Susan E Coulson, Jonathan R Clark
BACKGROUND: Facial paralysis remains a debilitating condition despite advances in medical, surgical and adjunctive interventions. Established grading systems used to assess facial paralysis and interventional outcomes have well described limitations. The Electronic Facial Paralysis Assessment (the eFACE), a clinician-graded zone-based facial function scale, has recently emerged as a grading tool that may provide greater sensitivity when assessing incomplete paralysis and post-surgical improvement...
March 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28338335/stress-induced-protein-s-glutathionylation-and-s-trypanothionylation-in-african-trypanosomes-a-quantitative-redox-proteome-and-thiol-analysis
#17
Kathrin Ulrich, Caroline Finkenzeller, Sabine Merker, Federico Rojas, Keith Matthews, Thomas Ruppert, R Luise Krauth-Siegel
AIMS: Trypanosomatids have a unique trypanothione-based thiol redox metabolism. The parasite-specific dithiol is synthesized from glutathione and spermidine, with glutathionylspermidine as intermediate catalyzed by trypanothione synthetase. In this study, we address the oxidative stress response of African trypanosomes with special focus on putative protein S-thiolation. RESULTS: Challenging bloodstream Trypanosoma brucei with diamide, H2O2 or hypochlorite results in distinct levels of reversible overall protein S-thiolation...
March 24, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28338066/chemical-composition-antioxidant-dna-damage-protective-cytotoxic-and-antibacterial-activities-of-cyperus-rotundus-rhizomes-essential-oil-against-foodborne-pathogens
#18
Qing-Ping Hu, Xin-Ming Cao, Dong-Lin Hao, Liang-Liang Zhang
Cyperus rotundus L. (Cyperaceae) is a medicinal herb traditionally used to treat various clinical conditions at home. In this study, chemical composition of Cyperus rotundus rhizomes essential oil, and in vitro antioxidant, DNA damage protective and cytotoxic activities as well as antibacterial activity against foodborne pathogens were investigated. Results showed that α-cyperone (38.46%), cyperene (12.84%) and α-selinene (11.66%) were the major components of the essential oil. The essential oil had an excellent antioxidant activity, the protective effect against DNA damage, and cytotoxic effects on the human neuroblastoma SH-SY5Y cell, as well as antibacterial activity against several foodborne pathogens...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337801/cross-cultural-comparisons-of-drinking-motives-in-10-countries-data-from-the-drinc-project
#19
Sean P Mackinnon, Marie-Eve Couture, M L Cooper, Emmanuel Kuntsche, Roisin M O'Connor, Sherry H Stewart
INTRODUCTION AND AIMS: This study tested the measurement invariance of the Drinking Motives Questionnaire-Revised Short Form (DMQ-R-SF) in undergraduates across 10 countries. We expected the four-factor structure to hold across countries, and for social motives to emerge as the most commonly endorsed motive, followed by enhancement, coping and conformity motives. We also compared individualistic and collectivistic countries to examine potential differences in the endorsement of drinking motives when countries were divided according to this broad cultural value...
March 23, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28337501/behavior-of-thiophanate-methyl-and-propiconazole-in-grape-and-mango-fruits-under-the-egyptian-field-conditions
#20
Amira Sh Soliman, Rania M A Helmy, Islam N Nasr, Mohamed S Abbas, Hend A Mahmoud, Wayne Jiang
This research aims at determining residues of thiophanate methyl and propiconazole in grape and mango fruits as an indication for their persistence in this environmental compartment. Fruit extracts were analyzed for thiophanate methyl using High Performance Liquid Chromatography and using Gas Chromatography Electron Capture Detector (GC/ECD), respectively. The results indicated that propiconazole had a less environmental impact since propiconazole had shorter residue half-lives which were 1.24 and 1.19 days in grape and mango fruits, respectively, while thiophanate methyl had half-lives of 2...
March 23, 2017: Bulletin of Environmental Contamination and Toxicology
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