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Sarah Coghill, John McNamara, Marion Woods, Krispin Hajkowicz
OBJECTIVES: To investigate the epidemiology, clinical characteristics and outcomes of those with hepatitis delta virus (HDV) infection in Queensland, Australia. DESIGN: Retrospective cohort study of individuals tested for HDV between 1997 and 2016 in the public healthcare system in Queensland. RESULTS: 179 individuals recorded positive HDV serology between 1997 and 2016, with a total of 4407 individuals undergoing testing (seroprevalence 4...
July 9, 2018: International Journal of Infectious Diseases: IJID
Raffaella Romeo, Arnolfo Petruzziello, Eve Isabel Pecheur, Floriana Facchetti, Riccardo Perbellini, Enrico Galmozzi, Najeeb Ullah Khan, Lucia Di Capua, Rocco Sabatino, Gerardo Botti, Giovanna Loquercio
Hepatitis delta virus (HDV) is a defective RNA virus that depends on the presence of hepatitis B virus (HBV) for the creation of new virions and propagation of the infection to hepatocytes. Chronic infection with HDV is usually associated with a worsening of HBV infection, leading more frequently to cirrhosis, increased risk of liver decompensation and hepatocellular carcinoma (HCC) occurrence. In spite of a progressive declining prevalence of both acute and chronic HDV infection observed over several years, mainly due to increased global health policies and mass vaccination against HBV, several European countries have more recently observed stable HDV prevalence mainly due to migrants from non-European countries...
July 11, 2018: Epidemiology and Infection
Luna Colagrossi, Romina Salpini, Rossana Scutari, Luca Carioti, Arianna Battisti, Lorenzo Piermatteo, Ada Bertoli, Lavinia Fabeni, Carmine Minichini, Pascale Trimoulet, Hervé Fleury, Elena Nebuloso, Maria De Cristofaro, Giuseppina Cappiello, Alberto Spanò, Vincenzo Malagnino, Terenzio Mari, Angelo Barlattani, Nerio Iapadre, Miriam Lichtner, Claudio Mastroianni, Ilaria Lenci, Caterina Pasquazzi, Giuseppe Maria De Sanctis, Alfonso Galeota Lanza, Maria Stanzione, Gianfranca Stornaiuolo, Massimo Marignani, Loredana Sarmati, Massimo Andreoni, Mario Angelico, Francesca Ceccherini-Silberstein, Carlo-Federico Perno, Nicola Coppola, Valentina Svicher
Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection. However, to-date no direct anti-HDV drugs are available in clinical practice. Here, we identified conserved and variable regions in HBsAg and HDAg domains in HBV + HDV infection, a critical finding for the design of innovative therapeutic agents. The extent of amino-acid variability was measured by Shannon-Entropy (Sn) in HBsAg genotype-d sequences from 31 HBV + HDV infected and 62 HBV mono-infected patients (comparable for demographics and virological-parameters), and in 47 HDAg genotype-1 sequences...
July 9, 2018: Viruses
Oidov Baatarkhuu, Tsagaantsooj Gerelchimeg, Dashchirev Munkh-Orshikh, Badamnachin Batsukh, Ganbold Sarangua, Jazag Amarsanaa
Mongolia is located between Russia and China. The total population of Mongolia as of December 2017 is estimated to be 3.2 million people. According to our previous study results, the prevalence of HBV was 11.8%, and anti-HDV was detected in 4.8% among the HBsAg-positive subjects. Interestingly, most HCV infection is caused by genotype 1b. Among all HBV DNA-positive samples, 98.5% were classified into genotype D, and regarding HDV genotypes, all HDV RNA-positive samples, 100%, were classified into genotype I...
January 2018: Euroasian Journal of Hepato-Gastroenterology
Benjamin Y Winer, Elham Shirvani-Dastgerdi, Yaron Bram, Julie Sellau, Benjamin E Low, Heath Johnson, Tiffany Huang, Gabriela Hrebikova, Brigitte Heller, Yael Sharon, Katja Giersch, Sherif Gerges, Kathleen Seneca, Mihai-Alexandru Pais, Angela S Frankel, Luis Chiriboga, John Cullen, Ronald G Nahass, Marc Lutgehetmann, Jared E Toettcher, Michael V Wiles, Robert E Schwartz, Alexander Ploss
Chronic delta hepatitis, caused by hepatitis delta virus (HDV), is the most severe form of viral hepatitis, affecting at least 20 million hepatitis B virus (HBV)-infected patients worldwide. HDV/HBV co- or superinfections are major drivers for hepatocarcinogenesis. Antiviral treatments exist only for HBV and can only suppress but not cure infection. Development of more effective therapies has been impeded by the scarcity of suitable small-animal models. We created a transgenic (tg) mouse model for HDV expressing the functional receptor for HBV and HDV, the human sodium taurocholate cotransporting peptide NTCP...
June 27, 2018: Science Translational Medicine
Yan Wang, Jeffrey S Glenn, Mark A Winters, Li-Ping Shen, Ingrid Choong, Ya-Lun Shi, Sheng-Li Bi, Li-Ying Ma, Hui Zeng, Fu-Jie Zhang
In this study, a real-time reverse transcription-polymerase chain reaction (real time RT-PCR) assay targeting 2 genetic segments was established to detect HDV RNA. Utilizing the World Health Organization International Standard for Hepatitis D Virus RNA, the lower limit of detection was 575 IU/mL, and the linearity of quantification ranged from 575,000 IU/mL to 575 IU/mL. 384 HBsAg-positive samples collected from China were tested by this method and HDV antibody detection. Eleven samples were positive for anti-HDV IgG which may persist after HDV resolution, 6 samples were HDV RNA positive, and 5 samples were positive for anti-HDV IgM...
May 29, 2018: Diagnostic Microbiology and Infectious Disease
Elizabeth Katwesigye, Emmanuel Seremba, Fred Semitala, Ponsiano Ocama
Background: Co-infection with hepatitis B (HBV) and hepatitis D (HDV) is common among human immunodeficiency virus (HIV) infected individuals in developing countries and it aggressively accelerates progression of liver disease to cirrhosis and other complications. There is scarcity of data on HDV in sub-Saharan Africa .We investigated the sero-prevalence and factors associated with HDV antibody among HIV/HBV co-infected patients attending a large urban HIV clinic in Uganda. Methods: We screened 189 HIV/HBV co-infected individuals for anti-HDV immunoglobulin G (IgG) and performed logistic regression to determine the associated factors...
December 2017: African Health Sciences
Andreas Krause, Uwe Haberkorn, Walter Mier
An estimated 240 million people worldwide are chronically infected with the hepatitis B virus (HBV). Despite readily available vaccination, HBV infections remain highly prevalent. As established HBV infections constitute a strong risk factor for developing hepatocellular carcinoma their treatment is a major task for the health system. Unfortunately, HBV is not curable with today's medicine. Approximately 15 million HBV patients have developed a hepatitis delta (HDV) infection on top of their HBV infection. The patients superinfected with this satellite virus suffer from a more severe disease development...
June 20, 2018: European Journal of Pharmacology
Antonio Aguilera, Javier Rodríguez-Calviño, Carmen de Mendoza, Vincent Soriano
BACKGROUND: The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals with HDV-antibodies and markers of resolved hepatitis B are considered cured. However, a subset shows elevated liver enzymes and hepatic fibrosis. Could they represent HBsAg-seronegative occult HDV infections? METHODS: We tested for HDV-antibodies 406 individuals with markers of past HBV exposure...
June 20, 2018: European Journal of Gastroenterology & Hepatology
Simon F Müller, Alexander König, Barbara Döring, Dieter Glebe, Joachim Geyer
The hepatic Na+/taurocholate co-transporting polypeptide (NTCP in man, Ntcp in animals) is the high-affinity receptor for the hepatitis B (HBV) and hepatitis D (HDV) viruses. Species barriers for human HBV/HDV within the order Primates were previously attributed to Ntcp sequence variations that disable virus-receptor interaction. However, only a limited number of primate Ntcps have been analysed so far. In the present study, a total of 11 Ntcps from apes, Old and New World monkeys were cloned and expressed in vitro to characterise their interaction with HBV and HDV...
2018: PloS One
Babak Sayad, Yosra Naderi, Seyed Moayed Alavian, Farid Najafi, Alireza Janbakhsh, Feyzollah Mansouri, Siavash Vaziri, Mandana Afsharian, Fatemeh Norooznezhad
Aim: This study aimed to determine the seroprevalence and viremic infection of hepatitis delta virus (HDV) in Kermanshah. Background: Hepatitis delta is one of the most complex viral infections of liver that along with hepatitis B virus could lead to fulminant hepatitis, progressive chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Methods: Referrals with positive HBs Ag were included and tested for HDV Ab using ELISA. Seropositives were subsequently evaluated for viremia by assaying HDV RNA and HBV DNA using real-time PCR...
2018: Gastroenterology and Hepatology From Bed to Bench
Mahwish Aftab, Iram Amin, Muhammad Idrees, Amjad Ali, Shazia Rafique, Shagufta Naz
OBJECTIVES: HBV and HDV are major public health problems with millions affected globally and Pakistan accounts for a significant proportion of the global Hepatitis burden. This cross sectional study was designed to assess the general epidemiological and virological features of HBV and HDV in the Punjab and Khyber Pakhtunkhawa (KP) provinces of Pakistan. METHODS: A total of 1890 HBV patients from March 2016 to May 2017 were recruited in the study and the presence of HDV was retrospectively evaluated in all participants...
June 12, 2018: Infection, Genetics and Evolution
Gunnar Lewon Lutterkort, Anika Wranke, Julia Hengst, Cihan Yurdaydin, Judith Stift, Birgit Bremer, Svenja Hardtke, Onur Keskin, Ramazan Idilman, Michael P Manns, Hans Peter Dienes, Christine Falk, Heiner Wedemeyer, Benjamin Heidrich
Chronic hepatitis D is caused by coinfection of hepatitis B and hepatitis D virus. While HDV is the dominant virus over HBV in the majority of cases, mechanisms and consequences of viral dominances are largely unknown. We aimed to investigate associations between viral dominance patterns and patients' characteristics and inflammatory features. 109 HDV patients treated with PEG-IFNa-2a within the international multicentre, prospective HIDIT-2 trial were studied. Patients were classified as D- or B-dominant if the viral load of one virus exceeded that of the other virus by more than 1log10 ...
June 11, 2018: Journal of Viral Hepatitis
Vadim G Krivoshapkin, Sergei I Semenov, Svetlana S Maximova, Nadegda N Tihonova, Anna I Sivtseva, Snegana S Sleptsova
OBJECTIVE: Inrtroduction: The epidemiological situation for hepatitis D has changed significantly. Reduced population authors infection due to a sharp decline in hospitalizations from Central Asia regions, the Caucasus and Moldova, which are known to be endemic for hepatitis D. Currently, the incidence of chronic hepatitis D (HGD) in Russia is 1%, while in the countries of Central Asia, and in particular in Turkmenistan, the share of HGD among chronic viral hepatitis is 8%. The aim of research was to establish the clinical features, depending on the activity of the replication of hepatitis viruses B and D...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Giacomo Diaz, Ronald E Engle, Ashley Tice, Marta Melis, Stephanie Montenegro, Jaime Rodriguez-Canales, Jeffrey Hanson, Michael R Emmert-Buck, Kevin W Bock, Ian N Moore, Fausto Zamboni, Sugantha Govindarajan, David Kleiner, Patrizia Farci
There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (n-5) and with non-HCC HDV cirrhosis (n=7) were studied using an integrated genomic approach. Transcriptomic profiling was performed using laser capture-microdissected (LCM) malignant and non-malignant hepatocytes, tumorous and non-tumorous liver tissue from patients with HDV-HCC, and liver tissue from patients with non-HCC HDV cirrhosis...
June 1, 2018: Molecular Cancer Research: MCR
C Jackson, R N Gunson, A Bradley-Stewart, S Bennett, H Black, N Kennedy, D J Bell
No abstract text is available yet for this article.
May 31, 2018: Journal of Viral Hepatitis
Cristina Stasi, Caterina Silvestri, Roberto Berni, Maurizia Rossana Brunetto, Anna Linda Zignego, Cristina Orsini, Stefano Milani, Liana Ricciardi, Andrea De Luca, Pierluigi Blanc, Cesira Nencioni, Donatella Aquilini, Alessandro Bartoloni, Giampaolo Bresci, Santino Marchi, Franco Filipponi, Piero Colombatto, Paolo Forte, Andrea Galli, Sauro Luchi, Silvia Chigiotti, Alessandro Nerli, Giampaolo Corti, Rodolfo Sacco, Paola Carrai, Angelo Ricchiuti, Massimo Giusti, Paolo Almi, Andrea Cozzi, Silvia Carloppi, Giacomo Laffi, Fabio Voller, Francesco Cipriani
AIM: To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus (HBV)-infected patients in the Tuscan public health care system. METHODS: This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation...
May 27, 2018: World Journal of Hepatology
Parag Mahale, Peter V Aka, Xiaohua Chen, Ping Liu, Benjamin J Fram, Alan S Wang, Scott Simenel, Fan-Chen Tseng, Sabrina Chen, Brian R Edlin, Jeffrey S Glenn, Thomas R O'Brien
People who inject drugs (PWID) are commonly exposed to hepatitis B virus (HBV) and hepatitis D virus (HDV). We evaluated the prevalence of HDV viremia among hepatitis B surface antigen (HBsAg)-positive PWID (n = 73) using a new quantitative microarray antibody capture (Q-MAC) assay, HDV western blot, and HDV RNA. HDV Q-MAC performed well in this cohort: anti-HDV, 100% sensitivity and specificity; HDV viremia, 61.5% sensitivity and 100% specificity. Hepatitis D viremia was present in 35.6% of HBsAg-positive participants and was more common in those with resolved compared to chronic hepatitis C (5...
May 25, 2018: Journal of Infectious Diseases
Mai Thanh Binh, Nghiem Xuan Hoan, Hoang Van Tong, Dao Phuong Giang, Bui Tien Sy, Nguyen Linh Toan, Le Huu Song, Mai Hong Bang, Heiner Wedemeyer, Christian G Meyer, Peter G Kremsner, C-Thomas Bock, Thirumalaisamy P Velavan
Hepatitis D caused by the hepatitis delta virus (HDV) is a serious health problem in many regions of the world. A total of 546 HBV-infected patients were enrolled from 2013 to 2015 and classified clinically into the subgroups of chronic hepatitis B (CHB, n = 191), liver cirrhosis (LC, n = 147) and hepatocellular carcinoma (HCC, n = 208). The patients were screened for HDV-RNA by nested PCR assays. HDV genotypes were assessed by direct sequencing, followed by phylogenetic analysis. HDV-RNA was identified in 13% (71/546) of HBV-infected patients...
May 23, 2018: Scientific Reports
Sara Di Cosmo, Maura Lusignani, Matteo Manini, Roberto Accardi
BACKGROUND AND AIM: Weight gain is frequently observed among liver transplanted patients. This condition is often associated to the development of other post LT morbidities which might influence the long-term post-transplant survival. However, the risk factors asso- ciated have not yet been identified. The aim of this study was to assess the prevalence of over- weight and obesity, to notice Body Mass Index changes and associated risk factors, within three years after LT. METHODS: All the patients consecutively transplanted at the Liver Transplantation Unit of Fondazione IRCCS "Cà-Granda Ospedale Maggiore Policlinico", Milan between January 2005 and June 2014 were retrospectively evaluated for inclusion...
January 2018: Professioni Infermieristiche
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