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https://www.readbyqxmd.com/read/29251788/nucleic-acid-polymer-rep-2139-and-nucleos-t-ide-analogues-act-synergistically-against-chronic-hepadnaviral-infection-in-vivo
#1
Jonathan Quinet, Catherine Jamard, Madeleine Burtin, Matthieu Lemasson, Sylviane Guerret, Camille Sureau, Andrew Vaillant, Lucyna Cova
Nucleic acid polymer (NAP) REP 2139 treatment was shown to block the release of viral surface antigen in DHBV-infected ducks and in patients with chronic HBV or HBV/HDV infection. In this preclinical study, a novel combination therapy consisting of REP 2139 with tenofovir disoproxil fumarate (TDF) and entecavir (ETV) was evaluated in vivo in the chronic DHBV infection model. DHBV-infected duck groups were treated as follows: normal saline (control); REP 2139-Ca; TDF; REP 2139-Ca + TDF; REP 2139-Ca + TDF + ETV...
December 18, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29241726/prevalence-and-risk-factors-of-hepatitis-d-virus-infection-in-patients-with-chronic-hepatitis-b-infection-attending-the-three-main-tertiary-hospitals-in-libya
#2
Abdel-Naser Elzouki, Saleh M Bashir, Omar Elahmer, Islam Elzouki, Fathi Alkhattali
BACKGROUND AND STUDY AIMS: Globally, More than 350 million individuals are chronically infected with hepatitis B virus (HBV), and >20 million of them are co-infected with hepatitis D virus (HDV). The aim of this study was to determine the pattern of HDV infection in patients with chronic hepatitis B in three main tertiary hospitals in Tripoli and Benghazi, Libya. PATIENTS AND METHODS: This cross sectional and descriptive study was conducted on 162 patients with chronic hepatitis B positive for more than six months) who were followed up at hepatitis clinics of the three main tertiary hospitals in Tripoli city (88 patients from Tripoli Medical Centre and Tripoli Central Hospital) and Benghazi city (74 patients from Aljomhoria Hospital) during the period from January 2010 to June 2012...
December 11, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29234199/prevalence-and-characteristics-of-hepatitis-delta-virus-infection-in-a-tertiary-hospital-setting-in-cameroon
#3
Henry N Luma, Servais A F B Eloumou, Cécile Okalla, Olivier Donfack-Sontsa, Ruth Koumitana, Agnes Malongue, Georges B Nko'Ayissi, Dominique N Noah
Background/Aims: Hepatitis B virus (HBV) and hepatitis D virus (HDV) coinfection is associated with more severe liver disease than HBV alone. More knowledge on the epidemiology and clinical impact of HDV-infected individuals is needed in Cameroon.We aimed at determining the frequency of anti-HDV antibody testing in hepatitis B surface antigen (HBsAg) positive patients, the proportion of anti-HDV positivity, and the characteristics of anti-HDV positive compared to anti-HDV negative patients in a tertiary hospital setting in Cameroon...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29225759/seroprevalence-of-hepatitis-b-c-and-d-viral-among-hemodialysis-patients-in-tehran
#4
Davood Yadegarynia, Hossein Hatamai, Sara Rahmati Roodsari, Zahra Arab-Mazar
Background and Objectives: Different studies show that the prevalence of hepatitis viruses in hemodialysis (HD) patients is much greater than general population. It is important to be aware of local prevalence data, in order to control infections and prevention of nosocomial transmission. The aim of this cross-sectional study was to investigate the seroprevalence of hepatitis B, C, and D viral infections among HD patients. Materials and Methods: During 2016, a cross-sectional study was conducted in Tehran, among 360 HD patients from 5 hemodialysis centers...
June 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29221492/elevated-serum-%C3%AE-2-microglobulin-in-individuals-coinfected-with-hepatitis-b-and-hepatitis-d-virus-in-a-rural-settings-in-southwest-nigeria
#5
Lawrence Ehis Okoror, Ayodele Oluwaseun Ajayi, Oluwaseun Benjamin Ijalana
OBJECTIVE: Coinfection of hepatitis B virus (HBV) with hepatitis D virus (HDV) has being reported to increase severity of progression to hepatocellular carcinoma (HCC) and liver cirrhosis (LC). Beta microglobulin (2βM) which is present on the surfaces of blood cells in acceptable levels is a tumor marker which may become elevated in disease conditions. This study hence observed the prevalence of HBV and HDV coinfection in a rural population and their 2βM concentration. RESULTS: Of the 368 samples, 66 (17...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29217749/hepatitis-delta-virus-persists-during-liver-regeneration-and-is-amplified-through-cell-division-both-in-vitro-and-in-vivo
#6
Katja Giersch, Oliver D Bhadra, Tassilo Volz, Lena Allweiss, Kristoffer Riecken, Boris Fehse, Ansgar W Lohse, Joerg Petersen, Camille Sureau, Stephan Urban, Maura Dandri, Marc Lütgehetmann
OBJECTIVE: Hepatitis delta virus (HDV) was shown to persist for weeks in the absence of HBV and for months after liver transplantation, demonstrating the ability of HDV to persevere in quiescent hepatocytes. The aim of the study was to evaluate the impact of cell proliferation on HDV persistence in vitro and in vivo. DESIGN: Genetically labelled human sodium taurocholate cotransporting polypeptide (hNTCP)-transduced human hepatoma(HepG2) cells were infected with HBV/HDV and passaged every 7 days for 100 days in the presence of the entry inhibitor Myrcludex-B...
December 7, 2017: Gut
https://www.readbyqxmd.com/read/29212929/nucleic-acid-polymers-are-active-against-hepatitis-delta-virus-infection-in-vitro
#7
Frauke Beilstein, Matthieu Blanchet, Andrew Vaillant, Camille Sureau
In this study, an in vitro infection model for the hepatitis delta virus (HDV) was used to evaluate the antiviral effects of phosphorothioate nucleic acid polymers (NAPs) and investigate their mechanism of action. The results show that NAPs inhibit HDV infection at less than 4 micromolar concentrations in cultures of differentiated human hepatoma cells. NAPs were shown to be active at viral entry, but inactive post entry on HDV RNA replication. Inhibition was independent of the NAPs nucleotide sequence, but dependent on both size and amphipathicity of the polymer...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29201776/viral-hepatitis-and-liver-diseases-in-mongolia
#8
REVIEW
Oidov Baatarkhuu, G Uugantsetseg, D Munkh-Orshikh, N Naranzul, S Badamjav, D Tserendagva, J Amarsanaa, Kim Do Young
Mongolia is known for its high endemicity for viral hepatitis. Previous studies report that the seroprevalence of hepatitis B virus (HBV) is 11.8% (178/1,512) among the unvaccinated population in 13 provinces and Ulaanbaatar city. The serosurvey of adults (>20 years of age) conducted during 2013 among persons in four provinces and in Ulaanbaatar showed that the overall prevalence of hepatitis B surface antigen (HBsAg) positivity was 10.6%. The overall prevalence of anti-hepatitis C virus (HCV) and HCV ribonucleic acid among 1,512 apparently healthy subjects was 15...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29127322/reduced-hepatitis-b-and-d-viral-entry-using-clinically-applied-drugs-as-novel-inhibitors-of-the-bile-acid-transporter-ntcp
#9
Joanne M Donkers, Benno Zehnder, Gerard J P van Westen, Mark J Kwakkenbos, Adriaan P IJzerman, Ronald P J Oude Elferink, Ulrich Beuers, Stephan Urban, Stan F J van de Graaf
The sodium taurocholate co-transporting polypeptide (NTCP, SLC10A1) is the main hepatic transporter of conjugated bile acids, and the entry receptor for hepatitis B virus (HBV) and hepatitis delta virus (HDV). Myrcludex B, a synthetic peptide mimicking the NTCP-binding domain of HBV, effectively blocks HBV and HDV infection. In addition, Myrcludex B inhibits NTCP-mediated bile acid uptake, suggesting that also other NTCP inhibitors could potentially be a novel treatment of HBV/HDV infection. This study aims to identify clinically-applied compounds intervening with NTCP-mediated bile acid transport and HBV/HDV infection...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126900/activity-of-nucleic-acid-polymers-in-rodent-models-of-hbv-infection
#10
Katrin Schöneweis, Neil Motter, Pia L Roppert, Mengji Lu, Baoju Wang, Ingo Roehl, Dieter Glebe, Dongliang Yang, John D Morrey, Michael Roggendorf, Andrew Vaillant
Nucleic acid polymers (NAPs) block the release of HBsAg from infected hepatocytes. These compounds have been previously shown to have the unique ability to eliminate serum surface antigen in DHBV-infected Pekin ducks and achieve multilog reduction of HBsAg or HBsAg loss in patients with chronic HBV infection and HBV/HDV coinfection. In ducks and humans, the blockage of HBsAg release by NAPs occurs by the selective targeting of the assembly and/or secretion of subviral particles (SVPs). The clinically active NAP species REP 2055 and REP 2139 were investigated in other relevant animal models of HBV infection including woodchucks chronically infected with WHV, HBV transgenic mice and HBV infected SCID-Hu mice...
November 8, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29119358/hepatitis-b-c-and-d-virus-genotypes-detected-in-hbsag-or-anti-hcv-positive-people-from-the-republic-of-moldova
#11
Ala Gori, Stela Gheorgita, Constantin Spinu, Iurie Pinzaru, Ala Halacu, Octavian Sajen, Luminița Suveica, Aurélie Sausy, Claude P Muller, Judith M Hübschen
In the Republic of Moldova, little is known about hepatitis B, C and D virus (HBV, HCV, HDV) genotypes, although the genetic variant may influence the course and outcome of disease. For HBV genotyping, 301 hepatitis B surface antigen (HBsAg)-positive sera collected in 2010 and 2011 from drug users, prison inmates, commercial sex workers, and the general population in different geographical regions were investigated. The 31 HBsAg-positive sera collected in 2011 were also tested for HDV. Eighty-eight anti-HCV-positive sera collected between 2010 and 2011 from the general population and health care workers were used for HCV genotyping...
November 8, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28988126/quantitative-characterization-of-hepatitis-delta-virus-genome-edition-by-next-generation-sequencing
#12
Sara Sopena, Cristina Godoy, David Tabernero, Maria Homs, Josep Gregori, Mar Riveiro-Barciela, Alicia Ruiz, Rafael Esteban, Maria Buti, Francisco Rodríguez-Frías
AIM: To determine the capacity of next-generation sequencing (NGS) for quantifying edited and unedited HDV populations, and to confirm if edition is a general phenomenon taking place along the entire HDV region analyzed, as we previously reported (Homs M et al. PLoS One 2016, 11, e0158557). METHODS: Four serum samples from 4 patients with chronic HDV/HBV infection were included in the study. The region selected for analysis covered 360 nucleotides (nt), positions 910-1270 of the HDV genome, which included the HDAg ORF editing site (nt 1014 within codon 196)...
October 4, 2017: Virus Research
https://www.readbyqxmd.com/read/28981470/telomere-dynamics-in-immune-senescence-and-exhaustion-triggered-by-chronic-viral-infection
#13
REVIEW
Marcia Bellon, Christophe Nicot
The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that this phenotype is recapitulated during chronic viral infection. The antigenic volume imposed by persistent and latent viruses exposes the immune system to unique challenges that lead to host T-cell exhaustion, characterized by impaired T-cell functions. These dysfunctional memory T cells lack telomerase, the protein capable of extending and stabilizing chromosome ends, imposing constraints on telomere dynamics...
October 5, 2017: Viruses
https://www.readbyqxmd.com/read/28977233/chronic-hepatitis-b-and-d-prognosis-according-to-child-pugh-score
#14
Marcelo Siqueira de Oliveira, Romeu Paulo Martins Silva, Suiane da Costa Negreiros do Valle, Elisabeth Níglio de Figueiredo, Dayana Fram
Objective: compare chronic hepatitis B patients to those superinfected with hepatitis D virus, according to Child-Pugh score regarding disease severity. Method: retrospective descriptive study, performed with 59 patients followed in the ambulatory, of which 22 (37.3%) were chronically infected with hepatitis B virus (Group HBV) and 37 (62.7%) superinfected with Delta virus (Group HBV+HDV); variables of sex, age and items of Child-Pugh score were collected by consulting medical records...
September 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28964701/safety-and-efficacy-of-rep-2139-and-pegylated-interferon-alfa-2a-for-treatment-naive-patients-with-chronic-hepatitis-b-virus-and-hepatitis-d-virus-co-infection-rep-301-and-rep-301-ltf-a-non-randomised-open-label-phase-2-trial
#15
Michel Bazinet, Victor Pântea, Valentin Cebotarescu, Lilia Cojuhari, Pavlina Jimbei, Jeffrey Albrecht, Peter Schmid, Frédéric Le Gal, Emmanuel Gordien, Adalbert Krawczyk, Hrvoje Mijočević, Hadi Karimzadeh, Michael Roggendorf, Andrew Vaillant
BACKGROUND: REP 2139 clears circulating hepatitis B virus (HBV) surface antigen (HBsAg), enhancing the restoration of functional control of HBV infection by immunotherapy. We assessed the safety and efficacy of REP 2139 and pegylated interferon alfa-2a in patients with chronic HBV and hepatitis D virus (HDV) co-infection. METHODS: In this open-label, non-randomised, phase 2 trial, patients aged 18-55 years, who were treatment naive, hepatitis B e antigen [HBeAg] negative, anti-hepatitis D antigen [HDAg] positive, and HDV RNA positive, with serum HBsAg concentrations of more than 1000 IU/mL, and a history of HDV infection for 6 months or more before treatment, were recruited at Toma Ciorbă Hospital of Infectious Diseases in Chișinău, Moldova...
September 27, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28963781/clinical-and-virological-heterogeneity-of-hepatitis-delta-in-different-regions-world-wide-the-hepatitis-delta-international-network-hdin
#16
Anika Wranke, Lourdes M Pinheiro Borzacov, Raymundo Parana, Cirley Lobato, Saeed Hamid, Emanoil Ceausu, George N Dalekos, Mario Rizzetto, Adela Turcanu, Grazia A Niro, Farheen Lubna, Minaam Abbas, Patrick Ingiliz, Maria Buti, Peter Ferenci, Thomas Vanwolleghem, Tonya Hayden, Naranjargal Dashdorj, Adriana Motoc, Markus Cornberg, Zaigham Abbas, Cihan Yurdaydin, Michael P Manns, Heiner Wedemeyer, Svenja Hardtke
Chronic hepatitis D (delta) is a major global health burden. Clinical and virological characteristics of patients with hepatitis D virus (HDV) infection and treatment approaches in different regions world-wide are poorly defined. METHODS: The Hepatitis Delta International Network (HDIN) registry was established in 2011 with centres in Europe, Asia, North- and South America. Here, we report on clinical/ virological characteristics of the first 1576 patients with ongoing or past HDV infection included in the database until October 2016 and performed a retrospective outcome analysis...
September 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28949917/a-potent-human-neutralizing-antibody-fc-dependently-reduces-established-hbv-infections
#17
Dan Li, Wenhui He, Ximing Liu, Sanduo Zheng, Yonghe Qi, Huiyu Li, Fengfeng Mao, Juan Liu, Yinyan Sun, Lijing Pan, Kaixin Du, Keqiong Ye, Wenhui Li, Jianhua Sui
Hepatitis B virus (HBV) infection is a major global health problem. Currently-available therapies are ineffective in curing chronic HBV infection. HBV and its satellite hepatitis D virus (HDV) infect hepatocytes via binding of the preS1 domain of its large envelope protein to sodium taurocholate cotransporting polypeptide (NTCP). Here, we developed novel human monoclonal antibodies that block the engagement of preS1 with NTCP and neutralize HBV and HDV with high potency. One antibody, 2H5-A14, functions at picomolar level and exhibited neutralization-activity-mediated prophylactic effects...
September 26, 2017: ELife
https://www.readbyqxmd.com/read/28903779/hepatitis-delta-virological-and-clinical-aspects
#18
REVIEW
Luan Felipo Botelho-Souza, Mariana Pinheiro Alves Vasconcelos, Alcione de Oliveira Dos Santos, Juan Miguel Villalobos Salcedo, Deusilene Souza Vieira
There are an estimated 400 million chronic carriers of HBV worldwide; between 15 and 20 million have serological evidence of exposure to HDV. Traditionally, regions with high rates of endemicity are central and northern Africa, the Amazon Basin, eastern Europe and the Mediterranean, the Middle East and parts of Asia. There are two types of HDV/HBV infection which are differentiated by the previous status infection by HBV for the individual. Individuals with acute HBV infection contaminated by HDV is an HDV/HBV co-infection, while individuals with chronic HBV infection contaminated by HDV represent an HDV/HBV super-infection...
September 13, 2017: Virology Journal
https://www.readbyqxmd.com/read/28899424/clade-homogeneity-and-low-rate-of-delta-virus-despite-hyperendemicity-of-hepatitis-b-virus-in-ethiopia
#19
Yeshambel Belyhun, Uwe Gerd Liebert, Melanie Maier
BACKGROUND: Although hepatitis B virus (HBV) is hyperendemic and heterogeneous in its genetic diversity in Ethiopia, little is known about hepatitis D virus (HDV) circulating genotypes and molecular diversity. METHODS: A total of 321 hepatitis B surface antigen (HBsAg) positives (125 HIV co-infected, 102 liver disease patients and 94 blood donors) were screened for anti-HDV antibody. The anti-HDV positive sera were subjected to Real time PCR for HDV-RNA confirmation...
September 12, 2017: Virology Journal
https://www.readbyqxmd.com/read/28884240/the-serological-markers-of-acute-infection-with-hepatitis-a-b-c-d-e-and-g-viruses-revisited
#20
REVIEW
Robério Amorim de Almeida Pondé
Viral hepatitis is a liver infection caused by one of the six hepatitis viruses: hepatitis A, B, C, D, E, and G virus (HAV to HEV and HGV). These agents differ in their biological, immunological, pathological and epidemiological characteristics. They cause infections that, when symptomatic, lead to clinical manifestations and laboratory findings that are not specific to a particular virus, often making differential diagnosis difficult, especially when no knowledge is available regarding the patient's medical history or the epidemiological background...
December 2017: Archives of Virology
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