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https://www.readbyqxmd.com/read/29356079/molecular-characterization-of-diarrheagenic-escherichia-coli-pathotypes-association-of-virulent-genes-serogroups-and-antibiotic-resistance-among-moderate-to-severe-diarrhea-patients
#1
Nutan Thakur, Swapnil Jain, Harish Changotra, Rahul Shrivastava, Yashwant Kumar, Neelam Grover, Jitendraa Vashistt
BACKGROUND: Diarrheagenic Escherichia coli (DEC) signifies as an important etiological agent of moderate-to-severe diarrhea. This study was primarily focused on molecular identification of DEC pathotypes; their association with serogroups and estimates of resistance profiles against different antibiotics regime. METHODS: Five hundred seventy-two stool specimens from diarrhea patients were investigated for DEC pathotypes. Molecular pathotypes were identified by amplification of virulence genes associated with distinct pathotypes followed by sequencing...
January 21, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29355549/air-pollution-exposure-is-associated-with-lower-lung-function-but-not-changes-in-lung-function-in-patients-with-idiopathic-pulmonary-fibrosis
#2
Kerri A Johannson, Eric Vittinghoff, Julie Morisset, Paul J Wolters, Elizabeth M Noth, John R Balmes, Harold R Collard
BACKGROUND: Air pollution exposure is associated with acute exacerbation, disease progression and mortality in patients with idiopathic pulmonary fibrosis (IPF). The objective of this study was to describe the impact of air pollution exposures on disease severity, and changes in lung function, in patients with IPF. METHODS: Using home spirometers and symptom diaries, 25 patients with IPF prospectively recorded forced vital capacity (FVC) weekly for up to 40 weeks...
January 17, 2018: Chest
https://www.readbyqxmd.com/read/29354807/main-air-pollutants-and-ventricular-arrhythmias-in-patients-with-implantable-cardioverter-defibrillators-a-systematic-review-and-meta-analysis
#3
Hong-Jie Yang, Xin Liu, Chuan Qu, Shao-Bo Shi, Jin-Jun Liang, Bo Yang
Objective: Previous studies of ambient air pollutants and ventricular arrhythmias in patients with implantable cardioverter-defibrillator (ICD) have yielded mixed results, and the association between air pollution and ventricular arrhythmias in these patients remains unclear. This study aimed to assess and quantify the association between exposure to major air pollutants [CO, inhalable particles (PM10), SO2, fine particulate matter (PM2.5), O3, and NO2] and the presence of ventricular arrhythmia in patients with ICD...
December 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29354273/local-scale-structures-across-the-morphotropic-phase-boundary-in-pbzr1-x-ti-x-o3
#4
Nan Zhang, Hiroko Yokota, A M Glazer, D A Keen, Semën Gorfman, P A Thomas, Wei Ren, Zuo-Guang Ye
Lead zirconate titanate (PZT) is one of the most widely studied piezoelectric materials, mainly because of its 'mysterious' relationship between the so-called morphotropic phase boundary (MPB) and its strong piezoelectric coupling factor. Using results from a pair distribution function analysis, this paper examines how the complex local structure in PZT affects the long-range average structure across the MPB. A monoclinic M C type structure is discovered in PZT. A first-order transformation between the monoclinic M A and M C components in both the average and local structures explains the sudden change in piezoelectric effect around these compositions...
January 1, 2018: IUCrJ
https://www.readbyqxmd.com/read/29351241/molecular-characterization-and-expression-profiles-of-sp-uchl3-and-sp-uchl5-during-gonad-development-of-scylla-paramamosain
#5
Kunhuang Han, Yanbin Dai, Ziping Zhang, Zhihua Zou, Yilei Wang
Ubiquitin C-terminal hydrolases (UCHLs) are a subset of deubiquitinating enzymes, and are involved in numerous physiological processes. However, the role of UCHLs during gonad development has not been studied in crustaceans. In this study, we have first cloned and analyzed expression profiling of Sp-uchl3 and Sp-uchl5 genes from mud crab Scylla paramamosain. The full-length cDNA of Sp-uchl3 is of 1804 bp. Its expression level in the ovary was significantly higher than in other tissues (p < 0.01), and during gonadal development, its expression in both O1 and O5 stages was significantly higher than in the other three stages of ovaries (p < 0...
January 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29350914/cys34-adductomes-differ-between-patients-with-chronic-lung-or-heart-disease-and-healthy-controls-in-central-london
#6
Sa Liu, Hasmik Grigoryan, William Matthew Bell Edmands, Sonia Dagnino, Rudy Sinharay, Paul Cullinan, Peter Collins, Kian Fan Chung, Benjamin M Barratt, Frank J Kelly, Paolo Vineis, Stephen M Rappaport
Oxidative stress generates reactive species that modify proteins, deplete antioxidant defenses and contribute to chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD). To determine whether protein modifications differ between COPD or IHD patients and healthy subjects, we performed untargeted analysis of adducts at the Cys34 locus of human serum albumin (HSA). Biospecimens were obtained from nonsmoking participants from London, U.K., including healthy subjects (n=20) and patients with COPD (n=20) or IHD (n=10)...
January 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29349885/a-hierarchical-z-scheme-%C3%AE-fe2-o3-g-c3-n4-hybrid-for-enhanced-photocatalytic-co2-reduction
#7
Zhifeng Jiang, Weiming Wan, Huaming Li, Shouqi Yuan, Huijun Zhao, Po Keung Wong
The challenge in the artificial photosynthesis of fossil resources from CO2 by utilizing solar energy is to achieve stable photocatalysts with effective CO2 adsorption capacity and high charge-separation efficiency. A hierarchical direct Z-scheme system consisting of urchin-like hematite and carbon nitride provides an enhanced photocatalytic activity of reduction of CO2 to CO, yielding a CO evolution rate of 27.2 µmol g-1 h-1 without cocatalyst and sacrifice reagent, which is >2.2 times higher than that produced by g-C3 N4 alone (10...
January 19, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29344415/rhizoma-coptidis-and-berberine-as-a-natural-drug-to-combat-aging-and-aging-related-diseases-via-anti-oxidation-and-ampk-activation
#8
REVIEW
Zhifang Xu, Wei Feng, Qian Shen, Nannan Yu, Kun Yu, Shenjun Wang, Zhigang Chen, Seiji Shioda, Yi Guo
Aging is the greatest risk factor for human diseases, as it results in cellular growth arrest, impaired tissue function and metabolism, ultimately impacting life span. Two different mechanisms are thought to be primary causes of aging. One is cumulative DNA damage induced by a perpetuating cycle of oxidative stress; the other is nutrient-sensing adenosine monophosphate-activated protein kinase (AMPK) and rapamycin (mTOR)/ ribosomal protein S6 (rpS6) pathways. As the main bioactive component of natural Chinese medicine rhizoma coptidis (RC), berberine has recently been reported to expand life span in Drosophila melanogaster, and attenuate premature cellular senescence...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29342195/association-between-pm10-pm2-5-no2-o3-and-self-reported-diabetes-in-italy-a-cross-sectional-ecological-study
#9
Riccardo Orioli, Giuseppe Cremona, Luisella Ciancarella, Angelo G Solimini
INTRODUCTION: Air pollution represents a serious threat to health on a global scale, being responsible for a large portion of the global burden of disease from environmental factors. Current evidence about the association between air pollution exposure and Diabetes Mellitus (DM) is still controversial. We aimed to evaluate the association between area-level ambient air pollution and self-reported DM in a large population sample in Italy. MATERIALS AND METHODS: We extracted information about self-reported and physician diagnosed DM, risk factors and socio-economic status from 12 surveys conducted nationwide between 1999 and 2013...
2018: PloS One
https://www.readbyqxmd.com/read/29339577/a-wearable-pressure-sensor-based-on-ultra-violet-ozone-microstructured-carbon-nanotube-polydimethylsiloxane-arrays-for-electronic-skins
#10
Guohui Yu, Jingdong Hu, Jianping Tan, Yang Gao, Yongfeng Lu, Fu-Zhen Xuan
Pressure sensors with high performance (e.g., a broad pressure sensing range, high sensitivities, rapid response/relaxation speeds, temperature-stable sensing), as well as a cost-effective and highly efficient fabrication method are highly desired for electronic skins. In this research, a high-performance pressure sensor based on microstructured carbon nanotube/polydimethylsiloxane arrays was fabricated using an ultra-violet/ozone (UV/O3) microengineering technique. The UV/O3 microengineering technique is controllable, cost-effective, and highly efficient since it is conducted at room temperature in an ambient environment...
January 17, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29339071/mir-155-5p-promotes-fibroblast-cell-proliferation-and-inhibits-foxo-signaling-pathway-in-vulvar-lichen-sclerosis-by-targeting-foxo3-and-cdkn1b
#11
Lina Ren, Yi Zhao, Xiaoxi Huo, Xin Wu
Vulvar lichen sclerosis (VLS) is a chronic inflammatory skin disorder. Evidence is accumulating that microRNAs (miRNAs) exert crucial roles in initiation and development of a wide range of human diseases. MiR-155-5p has been frequently reported to be implicated in the tumorigenesis and progression of multiple types of cancers, however, its biological role in VLS remains unclear. This study aimed to explore the role of miR-155-5p in VLS and clarify the potential molecular mechanisms involved. In the present study, miR-155-5p was observed to be significantly upregulated in VLS tissues...
January 12, 2018: Gene
https://www.readbyqxmd.com/read/29333607/arabidopsis-mlo2-is-a-negative-regulator-of-sensitivity-to-extracellular-ros
#12
Fuqiang Cui, Hongpo Wu, Omid Safronov, Panpan Zhang, Rajeev Kumar, Hannes Kollist, Jarkko Salojärvi, Ralph Panstruga, Kirk Overmyer
The atmospheric pollutant ozone (O3 ) is a strong oxidant that causes extracellular reactive oxygen species (ROS) formation, has significant ecological relevance, and is used here as a non-invasive ROS inducer to study plant signalling. Previous genetic screens identified several mutants exhibiting enhanced O3- sensitivity, but few with enhanced tolerance. We found that loss-of-function mutants in Arabidopsis MLO2, a gene implicated in susceptibility to powdery mildew disease, exhibit enhanced dose-dependent tolerance to O3 and extracellular ROS, but a normal response to intracellular ROS...
January 15, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29331891/global-association-between-ambient-air-pollution-and-blood-pressure-a-systematic-review-and-meta-analysis
#13
REVIEW
Bo-Yi Yang, Zhengmin Qian, Steven W Howard, Michael G Vaughn, Shu-Jun Fan, Kang-Kang Liu, Guang-Hui Dong
Although numerous studies have investigated the association of ambient air pollution with hypertension and blood pressure (BP), the results were inconsistent. We performed a comprehensive systematic review and meta-analysis of these studies. Seven international and Chinese databases were searched for studies examining the associations of particulate (diameter<2.5 μm (PM2.5), 2.5-10 μm (PM2.5-10) or >10 μm (PM10)) and gaseous (sulfur dioxide (SO2), nitrogen dioxide (NO2), nitrogen oxides (NOx), ozone (O3), carbon monoxide (CO)) air pollutants with hypertension or BP...
January 11, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29328519/surface-modification-using-the-biomimetic-method-in-alumina-zirconia-porous-ceramics-obtained-by-the-replica-method
#14
André D R Silva, Willian R Rigoli, Denise Osiro, Daphne C R Mello, Luana M R Vasconcellos, Anderson O Lobo, Eliria M J A Pallone
The modification of biomaterials approved by the Food and Drug Administration could be an alternative to reduce the period of use in humans. Porous bioceramics are widely used as support structures for bone formation and repair. This composite has essential characteristics for an implant, including good mechanical properties, high chemical stability, biocompatibility and adequate aesthetic appearance. Here, three-dimensional porous scaffolds of Al2 O3 containing 5% by volume of ZrO2 were produced by the replica method...
January 12, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29327581/direct-measurement-of-large-electrocaloric-effect-in-ba-zrxti1-x-o3-ceramics
#15
Xiaodong Jian, Biao Lu, Dandan Li, Yingbang Yao, Tao Tao, Bo Liang, Jin-Hong Guo, Yi-Jiang Zeng, Jia-Le Chen, Sheng-Guo Lu
Barium zirconate titanate (Ba(ZrxTi1-x)O3-BZT) ceramics with Zr4+ content x of 5, 10, 15, 20, 25 and 30 mol%, were prepared using a solid-state-reaction approach. The microstructures, morphologies, and electric properties were characterized using XRD, SEM and impedance analysis methods, respectively. The dielectric analyses indicate that the BZT bulk ceramics show characteristics of phase transition from a normal ferroelectric to a relaxor ferroelectric with the increasing Zr4+ ionic content. The electrocaloric effect (ECE) adiabatic temperature change decreases with the increasing Zr4+ content...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29327466/analysis-of-trace-levels-of-impurities-and-hydrogen-isotopes-in-helium-purge-gas-using-gas-chromatography-for-tritium-extraction-system-of-an-indian-lead-lithium-ceramic-breeder-test-blanket-module
#16
V Gayathri Devi, Amit Sircar, Deepak Yadav, Jayraj Parmar
In the fusion fuel cycle, the accurate analysis and understanding of the chemical composition of any gas mixture is of great importance for the efficient design of a tritium extraction and purification system or any tritium handling system. Methods like laser Raman spectroscopy and gas chromatography with thermal conductivity detector have been considered for hydrogen isotopes analyses in fuel cycles. Gas chromatography with a cryogenic separation column has been used for the analysis of hydrogen isotopes gas mixtures in general due to its high reliability and ease of operation...
January 12, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29323453/patterning-graphene-surfaces-with-iron-oxide-embedded-mesoporous-polypyrrole-and-derived-n-doped-carbon-of-tunable-pore-size
#17
Shuyan Zhu, Hao Tian, Nan Wang, Bin Chen, Yiyong Mai, Xinliang Feng
This study develops a novel strategy, based on block copolymer self-assembly in solution, for preparing two-dimensional (2D) graphene-based mesoporous nanohybrids with well-defined large pores of tunable sizes, by employing polystyrene-block-poly(ethylene oxide) (PS-b-PEO) spherical micelles as the pore-creating template. The resultant 2D nanohybrids possess a sandwich-like structure with Fe2 O3 nanoparticle-embedded mesoporous polypyrrole (PPy) monolayers grown on both sides of reduced graphene oxide (rGO) nanosheets (denoted as mPPy-Fe2 O3 @rGO)...
January 11, 2018: Small
https://www.readbyqxmd.com/read/29321656/evolution-of-poled-state-in-p-vdf-trfe-pb-ba-zr-ti-o3-composites-probed-by-temperature-dependent-piezoresponse-and-kelvin-probe-force-microscopy
#18
V V Shvartsman, D A Kiselev, A V Solnyshkin, D C Lupascu, M V Silibin
Polarized states of polymer/inorganic inclusion P(VDF-TrFE)-(Pb,Ba)(Zr,Ti)O3 composites are studied at the nanoscale using both piezoresponse force microscopy (PFM) and Kelvin probe force microscopy (KPFM). It has been shown that inorganic inclusions can be visualized using KPFM due to a discontinuity of the surface potential and polarization at the interface between the inclusions and the polymer matrix. The temperature evolution of the PFM and KPFM signal profiles is investigated. Softening of the polymer matrix on approaching the Curie temperature limits application of the contact PFM method...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321171/sgk1-foxo3-signaling-in-hypothalamic-pomc-neurons-mediates-glucocorticoid-increased-adiposity
#19
Yalan Deng, Yuzhong Xiao, Feixiang Yuan, Yaping Liu, Xiaoxue Jiang, Jiali Deng, Geza Fejes-Toth, Aniko Naray-Fejes-Toth, Shanghai Chen, Yan Chen, Hao Ying, Qiwei Zhai, Yousheng Shu, Feifan Guo
Although central nervous system has been implicated in glucocorticoid-induced fat mass gain, the underlying mechanisms are poorly understood. The aim of our current study was to investigate the possible involvement of hypothalamic serum- and glucocorticoid-regulated kinase 1 (SGK1) in glucocorticoid-increased adiposity. It is well-known that SGK1 expression is induced by acute glucocorticoid treatment, interestingly, we found its expression was decreased in the arcuate nucleus of the hypothalamus, including POMC neurons, following chronic dexamethasone (Dex) treatment...
January 10, 2018: Diabetes
https://www.readbyqxmd.com/read/29321054/the-association-between-daily-concentrations-of-air-pollution-and-visits-to-a-psychiatric-emergency-unit-a-case-crossover-study
#20
Anna Oudin, Daniel Oudin Åström, Peter Asplund, Steinn Steingrimsson, Zoltan Szabo, Hanne Krage Carlsen
BACKGROUND: Air pollution is one of the leading causes of mortality and morbidity worldwide. Experimental studies, and a few epidemiological studies, suggest that air pollution may cause acute exacerbation of psychiatric disorders, and even increase the rate of suicide attempts, but epidemiological studies on air pollution in association with psychiatric disorders are still few. Our aim was to investigate associations between daily fluctuations in air pollution concentrations and the daily number of visits to a psychiatric emergency unit...
January 10, 2018: Environmental Health: a Global Access Science Source
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