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JOURNAL ARTICLE
Virginia McKay, Yichen Chen, Kim Prewitt, Sara Malone, Maria Puerto-Torres, Carlos Acuña-Aguirre, Yvania Alfonso-Carreras, Shilel Y Alvarez-Arellano, Leticia A Andrade-Sarmiento, Daniela Arce-Cabrera, Deiby Argüello-Vargas, Mariuxy D C Barragán-García, Rosario Batista-Del-Cid, Erika E Blasco-Arriaga, Maria D C Cach-Castaneda, Gloria I Ceballo-Batista, Mayra Chávez-Rios, Maria E Costa, Maria E Cuencio-Rodriguez, Rosdali Diaz-Coronado, Ever A Fing-Soto, Teresa D J García-Sarmiento, Wendy C Gómez-García, Cinthia J Hernández-González, Yajaira V Jimenez-Antolinez, Maria S Juarez-Tobias, Esmeralda M León-López, Norma A Lopez-Facundo, Ruth A Martínez Soria, Scheybi T Miralda-Méndez, Erika Montalvo, Carlos M Pérez-Alvarado, Clara K Perez-Fermin, Monica L Quijano-Lievano, Beatriz Salas-Mendoza, Edwin E Sanchez-Fuentes, Marcia X Serrano-Landivar, Veronica Soto-Chavez, Isidoro Tejocote-Romero, Sergio Valle, Elizabeth A Vasquez-Roman, Juliana Texeira Costa, Adolfo Cardenas-Aguirre, Meenakshi Devidas, Douglas A Luke, Asya Agulnik
Clinical capacity for sustainability, or the clinical resources needed to sustain an evidence-based practice, represent proximal determinants that contribute to intervention sustainment. We examine the relationship between clinical capacity for sustainability and sustainment of PEWS, an evidence-based intervention to improve outcomes for pediatric oncology patients in resource-variable hospitals. We conducted a cross-sectional survey among Latin American pediatric oncology centers participating in Proyecto Escala de Valoración de Alerta Temprana (EVAT), an improvement collaborative to implement Pediatric Early Warning Systems (PEWS)...
March 2024: Glob Implement Res Appl
#22
JOURNAL ARTICLE
Cristian Rojas, Nicole Sarmiento, Emilia Ayora, Reinaldo Pis Diez
BACKGROUND: Veterinary antibiotics are chemical compounds used to kill or inhibit the growth of pathogenic bacteria associated with animal diseases. These molecules can be defined by the retention times (tR ) in liquid chromatography-mass spectrometry (LC-MS). One strategy to predict the tR of new veterinary antibiotics is the development of predictive quantitative structure-property relationship (QSPRs), which were used in this study. RESULTS: A database of 122 antibiotics was selected in which the tR was measured using a Hypersil Gold column...
March 29, 2024: Journal of the Science of Food and Agriculture
#23
JOURNAL ARTICLE
Diana Sánchez, Gabriela Cesarman-Maus, Laura Romero, Rogelio Sánchez-Verin, David Vail, Marina Guadarrama, Rosana Pelayo, Rosa Elena Sarmiento-Silva, Marcela Lizano
The absence of tumor-infiltrating lymphocytes negatively impacts the response to chemotherapy and prognosis in all subtypes of breast cancer. Therapies that stimulate a proinflammatory environment may help improve the response to standard treatments and also to immunotherapies such as checkpoint inhibitors. Newcastle disease virus (NDV) shows oncolytic activity, as well as immune modulating potential, in the treatment of breast cancer in vitro and in vivo; however, its potential to enhance tumor-infiltrating immune cells in breast cancer has yet to be evaluated...
February 28, 2024: Viruses
#24
REVIEW
Lauren L Porter, Irina Artsimovitch, César A Ramírez-Sarmiento
In the last two decades, our existing notion that most foldable proteins have a unique native state has been challenged by the discovery of metamorphic proteins, which reversibly interconvert between multiple, sometimes highly dissimilar, native states. As the number of known metamorphic proteins increases, several computational and experimental strategies have emerged for gaining insights about their refolding processes and identifying unknown metamorphic proteins amongst the known proteome. In this review, we describe the current advances in biophysically and functionally ascertaining the structural interconversions of metamorphic proteins and how coevolution can be harnessed to identify novel metamorphic proteins from sequence information...
March 26, 2024: Current Opinion in Structural Biology
#25
JOURNAL ARTICLE
Karen Sarmiento, Jorge Zambrano, Carlos Galvis, Álvaro Molina-Olivares, Marisol Margarita Villadiego-Molinares, Johanna Alejandra Ramírez-Martínez, Ana Lucía Castiblanco, Fabio A Aristizabal
The protein profile of Bothrops rhombeatus venom was compared to Bothrops asper and Bothrops atrox, and the effectiveness of antivenoms from the National Institute of Health of Colombia (INS) and Antivipmyn-Tri (AVP-T) of Mexico were analyzed. Protein profiles were studied with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and reverse-phase high-performance liquid chromatography (RP-HPLC). The neutralizing potency and the level of immunochemical recognition of the antivenoms to the venoms were determined using Western blot, affinity chromatography, and enzyme-linked immunosorbent assay (ELISA)...
March 15, 2024: Toxins
#26
Johanna Junker, Lara M Lange, Eva-Juliane Vollstedt, Karisha Roopnarain, Maria Leila M Doquenia, Azlina Ahmad-Annuar, Micol Avenali, Soraya Bardien, Natascha Bahr, Melina Ellis, Caterina Galandra, Thomas Gasser, Peter Heutink, Anastasia Illarionova, Yuliia Kanana, Ignacio J Keller Sarmiento, Kishore R Kumar, Shen-Yang Lim, Harutyun Madoev, Ignacio Mata, Niccolo E Mencacci, Mike A Nalls, Shalini Padmanabhan, Cholpon Shambetova, J Solle, Ai-Huey Tan, Joanne Trinh, Enza Maria Valente, Andrew Singleton, Cornelis Blauwendraat, Katja Lohmann, Zih-Hua Fang, Christine Klein
Until recently, about three-quarters of all monogenic Parkinson's disease (PD) studies were performed in European/White ancestry, thereby severely limiting our insights into genotype-phenotype relationships at global scale. The first systematic approach to embrace monogenic PD worldwide, the Michael J. Fox Foundation Global Monogenic PD (MJFF GMPD) Project, contacted authors of publications reporting individuals carrying pathogenic variants in known PD causing genes. In contrast, the Global Parkinson's Genetics Program's (GP2) Monogenic Network took a different approach by targeting PD centers not yet represented in the medical literature...
March 15, 2024: medRxiv
#27
JOURNAL ARTICLE
Cristina A Sarmiento, Jordan M Wyrwa, Chloe Glaros, Brooke Dorsey Holliman, Lisa A Brenner
AIM: To increase understanding regarding the experiences and values of young adults with cerebral palsy (CP), and their caregivers, regarding pediatric rehabilitation-related care, including perceived barriers and potential facilitators to transition to adult care. METHOD: This was a qualitative descriptive study that used 20 semi-structured interviews (13 caregivers and seven patient-caregiver dyads). RESULTS: We identified four major themes: (1) the value and security of long-term relationships; (2) feeling 'rudderless' navigating the logistics of transition; (3) differences in pediatric versus adult models of care; and (4) perceived lack of provider expertise and comfort in adult care settings...
March 24, 2024: Developmental Medicine and Child Neurology
#28
JOURNAL ARTICLE
Brayan Andrés Gamboa-Suárez, Ingrid Astrid Lotta-Arévalo, Felipe Sarmiento-Salazar, Nubia E Matta
Isolation of genomic DNA of blood parasites in birds, reptiles, amphibians, and fishes is a challenging task, given that their red blood cells are nucleated; for that reason, parasite genomic DNA is only a fraction of the total extracted DNA, and it is challenging to obtain concentrated high-quality genetic material. Percoll Density Gradient (PDG) and flow cytometry are tools for separating and analyzing cell populations or even a single cell, and both represent potent approaches for isolating avian haemosporidians parasites...
March 12, 2024: Veterinary Parasitology
#29
JOURNAL ARTICLE
Alondra Concepción-González, J Manuel Sarmiento, Christina C Rymond, Chinenye Ezeh, Rishi Sinha, Hannah Lin, Kevin Lu, Afrain Z Boby, Prakash Gorroochurn, A Noelle Larson, Benjamin D Roye, Brice Ilharreborde, Michael G Vitale
PURPOSE: In 2018, Best Practice Guidelines (BPGs) were published for preventing wrong-level surgery in pediatric spinal deformity, but successful implementation has not been established. The purpose of this study was to evaluate BPG compliance 5 years after publication. We hypothesized higher compliance among BPG authors and among surgeons with more experience, higher caseload, and awareness of the BPGs. METHODS: We queried North American and European surgeons, authors and nonauthors, and members of pediatric spinal study groups on adherence to BPGs using an anonymous survey consisting of 18 Likert scale questions...
March 21, 2024: Spine Deformity
#30
JOURNAL ARTICLE
Ana Isabel Martin-Quesada, Elisenda Llabres-Valentí, Cristina María Montesdeoca-Godoy, Carla Martín-Abreu, Cristina Alemán-Sánchez, Natalia Rodríguez-Pérez, Alicia Herrero-Márquez, Josefina Cruz-Jurado, María Hernández-Sosa, Melody Marrero-García, Cristina Victoria DelPino-Hernández, Samuel José Hernández-Sarmiento, Alejandra Rodríguez-Capote, Lina Pérez-Méndez, Isaac Núñez-Hernández
PURPOSE: Tri-weekly carboplatin is an established neoadjuvant treatment for triple-negative breast cancer, enhancing pathological complete response (pCR) and overall survival. This study explores if weekly carboplatin provides lower toxicity and comparable pCR rates. METHODS/PATIENTS: A retrospective multicenter study (January 2021 to March 2023) compares outcomes of weekly and tri-weekly carboplatin. RESULTS: Among 104 participants, 60% received weekly and 40% tri-weekly treatments...
March 21, 2024: Clinical & Translational Oncology
#31
JOURNAL ARTICLE
Alejandra Prian-Gaudiano, Daniela Horta-Carpinteyro, Andrea Sarmiento-Aguilar
BACKGROUND: Exclusive breastfeeding (BF) has the greatest potential impact on child mortality of any preventive intervention. Skin-to-skin contact (SSC) during the first hour of life is beneficial for initiating BF; however, routine separation of mother and infant is still common. This work aimed to demonstrate that SSC during the first hour of life is associated with a greater frequency and duration of exclusive BF. METHODS: This is an observational case-control study...
2024: Boletín Médico del Hospital Infantil de México
#32
JOURNAL ARTICLE
F Velázquez-Sarmiento, R I Rodríguez-Vivas, M A Alonso-Díaz, A Fernández-Salas, D Romero-Salas
The acaricidal effect of 14 strains of Metarhizium anisopliae sensu lato isolated from soil of livestock farms in the Mexican tropics was evaluated against larvae and engorged females, and during the laying and hatching of eggs of Rhipicephalus microplus (Ixodida: Ixodidae). For each fungal strain, the larvae mortality percentage was evaluated through a larval immersion test, while the reproductive efficiency indices in engorged females were measured using adult immersion tests at a dose of 1 × 108 conidia/ml...
March 1, 2024: Journal of Parasitology
#33
JOURNAL ARTICLE
David W Barham, Nikolaos Pyrgidis, Eliad Amini, Muhammed Hammad, Jake Miller, Robert Andrianne, Arthur L Burnett, Kelli Gross, Georgios Hatzichristodoulou, James Hotaling, Tung-Chin Hsieh, Lawrence C Jenkins, James M Jones, Aaron Lentz, Vaibhav Modgil, Daniar Osmonov, Sung Hun Park, Ian Pearce, Paul Perito, Hossein Sadeghi-Nejad, Maxime Sempels, Alfredo Suarez-Sarmiento, Jay Simhan, Koenraad van Renterghem, J Nicholas Warner, Matthew Ziegelmann, Faysal A Yafi, Martin S Gross
BACKGROUND: Variations in climate have been associated with a greater risk of surgical site infections, urinary tract infections, and changes in the skin microbiome; however, limited data exist on the impact of climate on inflatable penile prosthesis (IPP) infections. AIM: We sought to evaluate the impact of climate on the risk of IPP infections in a large international, multicenter cohort. METHODS: We performed a multi-institutional, retrospective study of patients undergoing IPP surgery...
March 13, 2024: Journal of Sexual Medicine
#34
JOURNAL ARTICLE
Carlos M Henrquez, Yessenia Sarmiento-Marina, Guillermo Salgado- Maldonado, Wilfredo A Matamoros
No abstract text is available yet for this article.
January 22, 2024: Zootaxa
#35
Isabella Van-Londoño, Camilo Ramírez-Giraldo, Julio César Martínez Echeverri, Juan José Villany-Sarmiento, Laura Marcela Fino-Velásquez
Eosinophilic gastroenteritis (EGE) is a rare disease which mainly consists of an abnormal eosinophile infiltration of the gastrointestinal tract. It's classified according to its location: eosinophilic esophagitis, eosinophilic gastritis, eosinophilic enteritis (including duodenum, jejunum and/or ileum) and eosinophilic colitis and degree of infiltration (mucosal, muscular, serosal). Depending on eosinophile concentration, type of EGE and the patient's condition it may manifest with different clinical presentations such as functional dyspepsia, abdominal pain, irritability, hypoproteinemia, diarrhea, anemia, among others...
March 15, 2024: Heliyon
#36
JOURNAL ARTICLE
J Manuel Sarmiento, Christina C Rymond, Abdulbaki Kozan, Lawrence G Lenke
BACKGROUND: Internal distraction rods have been described as an alternative to halo gravity traction for the treatment of severe scoliosis. Distraction rods can be challenging to use in patients with existing fusion masses. The authors report an internal distraction, construct-to-construct rod technique using multiple-hook fixation in a patient with a sharply angulated cervicothoracic scoliosis fusion mass. OBSERVATIONS: A 12-year-old female with previously diagnosed congenital scoliosis who had undergone cervical fusion in situ at age 2 presented to the clinic with shortness of breath exacerbated by increased levels of activity...
March 11, 2024: J Neurosurg Case Lessons
#37
JOURNAL ARTICLE
Christopher Dürrbeck, Isaac Neri Gomez-Sarmiento, Ioannis Androulakis, Birte Christina Sauer, Inger-Karine Kolkman-Deurloo, Christoph Bert, Luc Beaulieu
BACKGROUND: Electromagnetic tracking (EMT) systems have proven to be a valuable source of information regarding the location and geometry of applicators in patients undergoing brachytherapy (BT). As an important element of an enhanced and individualized pre-treatment verification, EMT can play a pivotal role in detecting treatment errors and uncertainties to increase patient safety. PURPOSE: The purpose of this study is two-fold: to design, develop and test a dedicated measurement protocol for the use of EMT-enabled afterloaders in BT and to collect and compare the data acquired from three different radiation oncology centers in different clinical environments...
March 8, 2024: Medical Physics
#38
JOURNAL ARTICLE
Jose Danilo Bengzon Diestro, Robert Fahed, Abdelsimar Tan Omar, Christine Hawkes, Eef J Hendriks, Clare Enriquez, Muneer Eesa, Grant Stotts, Hubert Lee, Shashank Nagendra, Alexandre Poppe, Célina Ducroux, Timothy Lim, Karl Narvacan, Michael Rizzuto, Afra Alfalahi, Hidehisa Nishi, Pragyan Sarma, Ze'ev Itsekson Hayosh, Katrina Ignacio, William Boisseau, Eduardo Pimenta Ribeiro Pontes Almeida, Anass Benomar, Mohammed A Almekhlafi, Genvieve Milot, Aviraj Deshmukh, Kislay Kishore, Donatella Tampieri, Jeffrey Wang, Abhilekh Srivastava, Daniel Roy, Federico Carpani, Nima Kashani, Claudia Candale-Radu, Nishita Singh, Maria Bres Bullrich, Robert Sarmiento, Ryan T Muir, Carmen Parra-Fariñas, Stephanie Reiter, Yan Deschaintre, Ravinder-Jeet Singh, Vivek Bodani, Aristeidis Katsanos, Ronit Agid, Atif Zafar, Vitor M Pereira, Julian Spears, Thomas R Marotta, Pascal Djiadeu, Sunjay Sharma, Forough Farrokhyar
BACKGROUND: Limited research exists regarding the impact of neuroimaging on endovascular thrombectomy (EVT) decisions for late-window cases of large vessel occlusion (LVO) stroke. OBJECTIVE: T0 assess whether perfusion CT imaging: (1) alters the proportion of recommendations for EVT, and (2) enhances the reliability of EVT decision-making compared with non-contrast CT and CT angiography. METHODS: We conducted a survey using 30 patients drawn from an institutional database of 3144 acute stroke cases...
March 7, 2024: Journal of Neurointerventional Surgery
#39
Mena Louis, Chad Copper, Elaine Lelli, Joseph Conway, Daniel Sarmiento, Hardeep Singh
The co-occurrence of Thrombocytopenia with Absent Radius (TAR) syndrome and Langerhans Cell Histiocytosis (LCH) is exceedingly rare, with scant documentation in existing medical literature. This case report aims to shed light on this unique intersection of conditions, emphasizing the diagnostic and therapeutic challenges it presents. A 27-year-old female with a history of TAR syndrome presented with microcytic anemia, hip pain, and gastrointestinal symptoms. Terminal ileum intubation during colonoscopy revealed superficial ulcerations, leading to a biopsy that confirmed LCH...
May 2024: Radiology Case Reports
#40
JOURNAL ARTICLE
Tobias Köhler, Abrar Mian, Matthew Ziegelmann, Nicole Dodge, Raza Mian, Sevann Helo, Alfredo Suarez-Sarmiento, Matthew Brennan, Paul Perito
Glans hypermobility (GH) is a well-described clinical entity that can have significant implications for cosmesis and function, resulting in sexual dissatisfaction, penile pain, and early device erosion, with an estimated incidence of 0.04% to 10%. We developed a novel grading scale to assess GH severity intraoperatively during primary inflatable penile prosthesis (IPP) placement and describe a modified glanspexy technique to correct GH when encountered during IPP placement. 530 patients who underwent primary IPP placements from two high-volume prosthetic surgeons between February 2018 - November 2019 were retrospectively reviewed in order to identify the incidence of GH...
March 5, 2024: International Journal of Impotence Research
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