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https://www.readbyqxmd.com/read/28198362/covalent-assembly-of-nanoparticles-as-a-peptidase-degradable-platform-for-molecular-mri
#1
Francisco Perez-Balderas, Sander I van Kasteren, Alaa A A Aljabali, Kim Wals, Sébastien Serres, Andrew Jefferson, Manuel Sarmiento Soto, Alexandre A Khrapitchev, James R Larkin, Claire Bristow, Seung Seo Lee, Guillaume Bort, Filippo De Simone, Sandra J Campbell, Robin P Choudhury, Daniel C Anthony, Nicola R Sibson, Benjamin G Davis
Ligand-conjugated microparticles of iron oxide (MPIO) have the potential to provide high sensitivity contrast for molecular magnetic resonance imaging (MRI). However, the accumulation and persistence of non-biodegradable micron-sized particles in liver and spleen precludes their clinical use and limits the translational potential of MPIO-based contrast agents. Here we show that ligand-targeted MPIO derived from multiple iron oxide nanoparticles may be coupled covalently through peptide linkers that are designed to be cleaved by intracellular macrophage proteases...
February 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28196162/the-use-of-recombinant-human-platelet-derived-growth-factor-for-maxillary-sinus-augmentation
#2
Atsushi Kubota, Hector Sarmiento, Mohammed Saad Alqahtani, Arturo Llobell, Joseph P Fiorellini
The maxillary sinus augmentation procedure has become a predictable treatment to regenerate bone for implant placement. The purpose of this study was to evaluate the effect of recombinant human platelet-derived growth factor BB (rhPDGF-BB) combined with a deproteinized cancellous bovine bone graft for sinus augmentation. The lateral window approach was used for maxillary sinuses with minimal residual bone. After a healing period of 4 months, dental implants were placed and then restored following a 2-month osseointegration period...
March 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28185666/-effects-of-a-recreational-general-physical-activity-program-with-short-term-and-moderate-intensity-of-blood-pressure-and-other-cardiovascular-risk-factors-in-hypertensive-patients-over-50-years-old
#3
Ana Torija Archilla, Javier Pérez González, Álvaro Sarmiento Ramírez, Enrique Fernández Sánchez, Josué Rubén González Ruiz, Rafael Guisado Barrilao
OBJECTIVES: To evaluate the effects of a recreational general physical activity program with moderate intensity and short duration on blood pressure and other cardiovascular risk factors (BMI, cholesterol, Rest Heart Rate, HDL, LDL, Triglycerides) in hypertensive patients older than 50years. DESIGN: Non-randomised pre-post design, quasi-experimental study. LOCATION: Íllora, Granada, Spain. PARTICIPANTS: A total of 60 subjects aged 50-75years taking part in the Health Hypertensive Program in the Medical Centre were selected...
February 6, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28169531/branimycins-b-and-c-antibiotics-produced-by-the-abyssal-actinobacterium-pseudonocardia-carboxydivorans-m-227
#4
Alfredo F Braña, Aida Sarmiento-Vizcaíno, Ignacio Pérez-Victoria, Luis Otero, Jonathan Fernández, Juan José Palacios, Jesús Martín, Mercedes de la Cruz, Caridad Díaz, Francisca Vicente, Fernando Reyes, Luis A García, Gloria Blanco
Two new antibiotics, branimycins B (2) and C (3), were produced by fermentation of the abyssal actinobacterium Pseudonocardia carboxydivorans M-227, isolated from deep seawater of the Avilés submarine Canyon. Their structures were elucidated by HRMS and NMR analyses. These compounds exhibit antibacterial activities against a panel of Gram-positive bacteria, including Corynebacterium urealyticum, Clostridium perfringens, and Micrococcus luteus, and against the Gram-negative bacterium Neisseria meningitidis...
February 7, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28167034/stwrky8-transcription-factor-regulates-benzylisoquinoline-alkaloid-pathway-in-potato-conferring-resistance-to-late-blight
#5
Kalenahalli N Yogendra, Dhananjay Dhokane, Ajjamada C Kushalappa, Felipe Sarmiento, Ernesto Rodriguez, Teresa Mosquera
The resistance to late blight is either qualitative or quantitative in nature. Quantitative resistance is durable, but challenging due to polygenic inheritance. In the present study, the diploid potato genotypes resistant and susceptible to late blight, were profiled for metabolites. Tissue specific metabolite analysis of benzylisoquinoline alkaloids (BIAs) in response to pathogen infection revealed increased accumulation of morphinone, codeine-6-glucuronide and morphine-3-glucuronides. These BIAs are antimicrobial compounds and possibly involved in cell wall reinforcement, especially through cross-linking cell wall pectins...
March 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28161847/study-of-gastrointestinal-parasites-in-water-buffalo-bubalus-bubalis-reared-under-mexican-humid-tropical-conditions
#6
Nadia Florencia Ojeda-Robertos, Oswaldo Margarito Torres-Chablé, Jorge Alonso Peralta-Torres, Carlos Luna-Palomera, Aguilar Aguilar-Cabrales, Alfonso Juventino Chay-Canul, Roberto González-Garduño, Carlos Machain-Williams, Ramón Cámara-Sarmiento
The objective was to determine the frequency of gastrointestinal parasites (GP) genera affecting water buffalo (Bubalus bubalis) reared under humid tropical conditions of Mexico. Three hundred eighty-three Munrah breed water buffalo were included, 251 adult females and 132 calves. Feces were directly collected form the rectum of the animals and processed by the McMaster technique. Coprocultures were made to identify the genera of the nematodes. The frequency of GP in B. bubalis was 42%, independently of their age, 60% of calves resulted parasitized...
February 4, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28159238/in-vitro-effects-of-tamoxifen-on-equine-neutrophils
#7
C Borlone, N Morales, C Henriquez, H Folch, C Olave, J Sarmiento, B Uberti, G Moran
Neutrophils participate in innate immunity as the first line of host defense against microorganisms. However, exacerbated neutrophil activity can be harmful to surrounding tissues; this is important in a range of diseases, including allergic asthma and chronic obstructive pulmonary disease in humans, and equine asthma (also known as recurrent airway obstruction (RAO). Tamoxifen (TX) is a non-steroidal estrogen receptor modulator with effects on cell growth and survival. Previous preliminary studies showed that TX treatment in horses with induced acute pulmonary inflammation promoted early apoptosis of blood and BALF neutrophils, reduction of BALF neutrophils, and improvement in animals' clinical status...
February 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28157227/association-of-vav2-and-vav3-polymorphisms-with-cardiovascular-risk-factors
#8
Nuria Perretta-Tejedor, Javier Fernández-Mateos, Luis García-Ortiz, Manuel A Gómez-Marcos, José I Recio-Rodríguez, Cristina Agudo-Conde, Emiliano Rodriguez-Sánchez, Ana I Morales, Francisco J López-Hernández, José M López-Novoa, Rogelio González-Sarmiento, Carlos Martínez-Salgado
Hypertension, diabetes and obesity are cardiovascular risk factors closely associated to the development of renal and cardiovascular target organ damage. VAV2 and VAV3, members of the VAV family proto-oncogenes, are guanosine nucleotide exchange factors for the Rho and Rac GTPase family, which is related with cardiovascular homeostasis. We have analyzed the relationship between the presence of VAV2 rs602990 and VAV3 rs7528153 polymorphisms with cardiovascular risk factors and target organ damage (heart, vessels and kidney) in 411 subjects...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28146192/-zika-virus-infection-in-pregnancy-fetal-and-neonatal-impact
#9
Wilfrido Coronell-Rodríguez, Cindy Arteta-Acosta, M Alejandra Suárez-Fuentes, M Cecilia Burgos-Rolon, M Teresa Rubio-Sotomayor, Michelle Sarmiento-Gutiérrez, Carlos Corzo-Díaz
Zika virus (ZV) is an arbovirus transmitted by Aedes aegypti and A. albopictus. The neurotropic profile of this virus is known since 1952. The main finding related to ZV in America is microcephaly. Two hypotheses are tested on its involvement in the central nervous system: its neurotropic feature and the direct effect of ZV on the placenta. Malformations and clinical findings on fetal development comprise congenital Zika syndrome. RT-PCR and serology (IgM) are useful for definitive diagnosis. However, we should keep in mind first that the viremia in pregnant women can stay for a longer period of time, and second, a positive IgM for Zika should be properly interpreted in an endemic area to other flavivirus...
December 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28146100/echovirus-6-infects-human-exocrine-and-endocrine-pancreatic-cells-and-induces-pro-inflammatory-innate-immune-response
#10
Luis Sarmiento, Gun Frisk, Mahesh Anagandula, Monika Hodik, Ilaria Barchetta, Eitan Netanyah, Eduardo Cabrera-Rode, Corrado M Cilio
Human enteroviruses (HEV), especially coxsackievirus serotype B (CVB) and echovirus (E), have been associated with diseases of both the exocrine and endocrine pancreas, but so far evidence on HEV infection in human pancreas has been reported only in islets and ductal cells. This study aimed to investigate the capability of echovirus strains to infect human exocrine and endocrine pancreatic cells. Infection of explanted human islets and exocrine cells with seven field strains of E6 caused cytopathic effect, virus titer increase and production of HEV protein VP1 in both cell types...
January 30, 2017: Viruses
https://www.readbyqxmd.com/read/28127901/integrated-pest-management-in-western-flower-thrips-past-present-and-future
#11
REVIEW
Sanae Mouden, Kryss Facun Sarmiento, Peter G L Klinkhamer, Kirsten A Leiss
Western flower thrips (WFT) is one of the most economically important pest insects of many crops worldwide. Recent EU legislation has caused a dramatic shift in pest management strategies, pushing for tactics that are less reliable on chemicals. The development of alternative strategies is therefore, an issue of increasing urgency. This paper reviews the main control tactics in integrated pest management (IPM) of WFT with focus on biological control and host plant resistance as areas of major progress. Knowledge gaps are identified and innovative approaches emphasized, highlighting the advances in -omics technologies...
January 27, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28125715/correction-study-of-association-between-pre-senile-cataracts-and-the-polymorphisms-rs2228000-in-xpc-and-rs1042522-in-p53-in-spanish-population
#12
Gloria López Valverde, Elena Garcia Martin, José M Larrosa Povés, Vicente Polo Llorens, Javier Fernández Mateos, Luis E Pablo Júlvez, Rogelio González Sarmiento
[This corrects the article DOI: 10.1371/journal.pone.0156317.].
2017: PloS One
https://www.readbyqxmd.com/read/28119807/regulation-of-multidrug-resistance-by-micrornas-in-anti-cancer-therapy
#13
REVIEW
Xin An, Cesar Sarmiento, Tao Tan, Hua Zhu
Multidrug resistance (MDR) remains a major clinical obstacle to successful cancer treatment. Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of drugs transporters, defects of apoptosis and autophagy machinery, alterations of drug metabolism and drug targets, disrupti on of redox homeostasis, the exact mechanisms of MDR in a specific cancer patient and the cross-talk among these different mechanisms and how they are regulated are poorly understood. MicroRNAs (miRNAs) are a new class of small noncoding RNAs that could control the global activity of the cell by post-transcriptionally regulating a large variety of target genes and proteins expression...
January 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28115722/reconciling-fisheries-catch-and-ocean-productivity
#14
Charles A Stock, Jasmin G John, Ryan R Rykaczewski, Rebecca G Asch, William W L Cheung, John P Dunne, Kevin D Friedland, Vicky W Y Lam, Jorge L Sarmiento, Reg A Watson
Photosynthesis fuels marine food webs, yet differences in fish catch across globally distributed marine ecosystems far exceed differences in net primary production (NPP). We consider the hypothesis that ecosystem-level variations in pelagic and benthic energy flows from phytoplankton to fish, trophic transfer efficiencies, and fishing effort can quantitatively reconcile this contrast in an energetically consistent manner. To test this hypothesis, we enlist global fish catch data that include previously neglected contributions from small-scale fisheries, a synthesis of global fishing effort, and plankton food web energy flux estimates from a prototype high-resolution global earth system model (ESM)...
January 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28111613/international-comparisons-of-the-associations-between-objective-measures-of-the-built-environment-and-transport-related-walking-and-cycling-ipen-adult-study
#15
Lars B Christiansen, Ester Cerin, Hannah Badland, Jacqueline Kerr, Rachel Davey, Jens Troelsen, Delfien van Dyck, Josef Mitáš, Grant Schofield, Takemi Sugiyama, Deborah Salvo, Olga L Sarmiento, Rodrigo Reis, Marc Adams, Larry Frank, James F Sallis
INTRODUCTION: Mounting evidence documents the importance of urban form for active travel, but international studies could strengthen the evidence. The aim of the study was to document the strength, shape, and generalizability of relations of objectively measured built environment variables with transport-related walking and cycling. METHODS: This cross-sectional study maximized variation of environments and demographics by including multiple countries and by selecting adult participants living in neighborhoods based on higher and lower classifications of objectively measured walkability and socioeconomic status...
December 2016: Journal of Transport & Health
https://www.readbyqxmd.com/read/28106434/observation-of-mollow-triplets-with-tunable-interactions-in-double-lambda-systems-of-individual-hole-spins
#16
K G Lagoudakis, K A Fischer, T Sarmiento, P L McMahon, M Radulaski, J L Zhang, Y Kelaita, C Dory, K Müller, J Vučković
Although individual spins in quantum dots have been studied extensively as qubits, their investigation under strong resonant driving in the scope of accessing Mollow physics is still an open question. Here, we have grown high quality positively charged quantum dots embedded in a planar microcavity that enable enhanced light-matter interactions. Under a strong magnetic field in the Voigt configuration, individual positively charged quantum dots provide a double lambda level structure. Using a combination of above-band and resonant excitation, we observe the formation of Mollow triplets on all optical transitions...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28104048/mental-health-in-immigrants-versus-native-population-a-systematic-review-of-the-literature
#17
REVIEW
Pilar Bas-Sarmiento, María José Saucedo-Moreno, Martina Fernández-Gutiérrez, Miriam Poza-Méndez
: The relationship between psychopathology and migration presents unresolved questions. OBJECTIVES: To determine whether there is a higher incidence of mental illness among immigrants, to describe the nosologic differences between immigrant and native populations, and to identify the risk factors involved of immigration. METHODS: A systematic review was conducted using the PubMed, Science Direct, ISI, Scopus, Psycinfo, Cochrane, and Cuiden databases...
February 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28099555/modulation-of-the-ultradian-human-nasal-cycle-by-sleep-stage-and-body-position
#18
Richard E Frye, Deborah F Rosin, Adrian R Morrison, Fidias E Leon-Sarmiento, Richard L Doty
Objective: The nasal cycle, which is present in a significant number of people, is an ultradian side-to-side rhythm of nasal engorgement associated with cyclic autonomic activity. We studied the nasal cycle during REM/non-REM sleep stages and examined the potentially confounding influence of body position on lateralized nasal airflow. Methods: Left- and right-side nasal airflow was measured in six subjects during an eight-hour sleep period using nasal thermistors...
January 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28076550/suicide-in-university-students-in-bogot%C3%A3-colombia-2004-2014
#19
Saúl Alonso Franco, Martha Lucia Gutiérrez, Julián Sarmiento, Decsy Cuspoca, Javier Tatis, Alejandro Castillejo, Miguel Barrios, Magnolia Del Pilar Ballesteros-Cabrera, Sara Zamora, Carlos Iván Rodríguez
We report the results of a retrospective, descriptive, qualitative study of suicide among university students in Bogotá, Colombia. The objective of this study was to document the magnitude, principal characteristics, and impact of this phenomenon in the selected population. A semi-structured survey was employed to collect information from 66 individuals linked to the universities. A total of 45 cases of suicide were documented in the study period (2004 - 2014). Of these, 69% occurred in males and 31% in females...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28073517/predictive-factors-of-long-term-colorectal-cancer-survival-after-ultrasound-controlled-metastatic-hepatic-ablation
#20
Carmen Rosa Hernández-Socorro, Pedro Saavedra, José Ramírez Felipe, Uriel Bohn Sarmiento, Sergio Ruiz-Santana
BACKGROUND AND OBJECTIVE: The risk factors associated to long-term survival were assessed in patients with liver metastases of colorectal carcinoma undergoing ablative therapies. PATIENTS AND METHODS: Single-centre cohort study, retrospectively analysed and prospectively collected consecutive patients with unresectable metastatic liver disease of colorectal carcinoma treated with ablative therapies between 1996 and 2013. Factors associated with survival time were identified using Cox's proportional hazard model with time-dependent covariates...
January 7, 2017: Medicina Clínica
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