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https://www.readbyqxmd.com/read/28636902/-riddle-me-this-substrate-channeling-solves-the-paradigms-of-camp-dependent-activation-of-pka
#1
César A Ramírez-Sarmiento
No abstract text is available yet for this article.
June 20, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28633454/long-term-efficacy-of-ultrasound-guided-injection-of-incobotulinumtoxina-in-piriformis-syndrome
#2
Manuel Rodríguez-Piñero, Victoria Vidal Vargas, Aguas Santas Jiménez Sarmiento
No abstract text is available yet for this article.
June 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28627087/familial-seborrhoeic-keratosis-associated-with-multiple-pure-reticulated-acanthomas-and-infundibulocystic-basal-cell-carcinomas
#3
J Agustí, R Bella-Navarro, A B García-García, E Bueno, R González-Sarmiento, L Navarro, B Sanchez-Sendra, A Revert, E Jordá, C Monteagudo
BACKGROUND: A variety of genodermatoses with multiple cutaneous tumors with germline genetic alterations such as Gorlin syndrome with PTCH1 gene mutations have been described. Other cutaneous syndromes have been associated with somatic gene mutations, such as FGFR3 in familial seborrhoeic keratosis. OBJECTIVE: We describe the clinical, dermoscopic, and histopathological features of multiple cutaneous lesions, mostly infundibulocystic basal cell carcinomas and pure reticulated acanthomas, present in a family affected by familial seborrhoeic keratosis...
June 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28622989/rare-earth-elements-mobility-processes-in-an-amd-affected-estuary-huelva-estuary-sw-spain
#4
K L Lecomte, A M Sarmiento, J Borrego, J M Nieto
Huelva Estuary is a transition zone where REE-rich acidic waters interact with saline-alkaline seawater. This mixing process influences the geochemical and mineralogical characteristics of particulate and dissolved fractions. The Tinto River has >11,000μgL(-1) dissolved REE (pH=1.66), whereas seawater only reaches 8.75·10(-2)μgL(-1) dissolved REE (pH=7.87). REE-normalized patterns in "pH<6 solutions" are parallel and show similarities, diminishing their concentration as pH increases. Sequential extraction performed on the generated precipitates of mixed solutions indicates that most REE are associated to the residual phase...
June 13, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28622182/reflux-associated-cholecystopathy-analysis-of-76-gallbladders-from-patients-with-supra-oddi-union-of-the-pancreatic-duct-and-common-bile-duct-pancreatobiliary-maljunction-elucidates-a-specific-diagnostic-pattern-of-mucosal-hyperplasia-as-a-prelude-to-carcinoma
#5
Takashi Muraki, Bahar Memis, Michelle D Reid, Takeshi Uehara, Tetsuya Ito, Osamu Hasebe, Shinji Okaniwa, Naoto Horigome, Takeshi Hisa, Pardeep Mittal, Alexa Freedman, Shishir Maithel, Juan M Sarmiento, Alyssa Krasinskas, Jill Koshiol, Volkan Adsay
Pancreaticobiliary maljunction (PBM) is the anomalous union of the main pancreatic duct and common bile duct outside the Oddi-sphincter, allowing the reflux of pancreatic juice to the gallbladder. There is only limited awareness and understanding of the pathologic correlates of this condition, mostly from Japan; this entity is largely unrecognized in the West. In this study, 76 gallbladders from patients with PBM (64 from Japan; 12 from the United States) were analyzed and contrasted with 66 from non-PBM patients...
June 15, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28614433/diagnostic-labels-of-nanda-i-in-a-southern-region-of-spain
#6
Rafael González-Rodríguez, María de Los Ángeles Martelo-Baro, Pilar Bas-Sarmiento
Objective: to determine the incidence of NANDA-I diagnostic labels (North American Nursing Diagnosis Association-International) and to establish the distribution of cases of assistance and the associated labels, according to sociodemographic variables (age and sex). Method: descriptive, cross-sectional epidemiological study of labels of NANDA-I, under ecological design. The distribution of labels was analyzed according to sex and age; the corresponding frequencies were calculated and for each label the incidence were calculated rates with aggregate data from the attended cases...
June 8, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28612322/integrative-assessment-of-sediment-quality-in-lower-basin-affected-by-former-mining-in-brazil
#7
Estefanía Bonnail, Lucas M Buruaem, Lucas G Morais, Giuliana S Araujo, Denis M S Abessa, Aguasanta M Sarmiento, T Ángel DelValls
The Ribeira de Iguape River (Southeast Brazil) is metal contaminated by mining activities. Despite it has been cataloged as "in via of restoration" by the literature, this basin is still a sink of pollution in some segments of the fluvial system. This study aimed to assess the sediment quality in the lower part of the RIR basin. The employed approach was based on biological responses of the freshwater clam Corbicula fluminea after 7-day exposure bioassays using as the reference site the Perequê Ecological Park...
June 13, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28609733/a-novel-approach-for-acid-mine-drainage-pollution-biomonitoring-using-rare-earth-elements-bioaccumulated-in-the-freshwater-clam-corbicula-fluminea
#8
Estefanía Bonnail, Rafael Pérez-López, Aguasanta M Sarmiento, José Miguel Nieto, T Ángel DelValls
Lanthanide series have been used as a record of the water-rock interaction and work as a tool for identifying impacts of acid mine drainage (lixiviate residue derived from sulphide oxidation). The application of North-American Shale Composite-normalized rare earth elements patterns to these minority elements allows determining the origin of the contamination. In the current study, geochemical patterns were applied to rare earth elements bioaccumulated in the soft tissue of the freshwater clam Corbicula fluminea after exposure to different acid mine drainage contaminated environments...
June 4, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28609280/the-history-behind-successful-uterine-transplantation-in-humans
#9
Luis Arturo Ruvalcaba Castellón, Martha Isolina García Amador, Roberto Enrique Díaz González, Montoya Sarmiento Jorge Eduardo, César Díaz-García, Niclas Kvarnström, Mats Bränström
This paper aimed to describe the basic aspects of uterine transplant (UTx) research in humans, including preliminary experiences in rodents and domestic species. Studies in rats, domestic species, and non-human primates validated and optimized the UTx procedure in terms of its surgical aspects, immunosuppression, rejection diagnosis, peculiarities of pregnancy in immunosuppressed patients, and patients with special uterine conditions. In animal species, the first live birth from UTx was achieved in a syngeneic mouse model in 2003...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28609220/reconstruction-options-for-pancreaticoduodenectomy-in-patients-with-prior-roux-en-y-gastric-bypass
#10
Mihir M Shah, Benjamin M Martin, Jamil L Stetler, Ankit D Patel, S Scott Davis, Juan M Sarmiento, Edward Lin
BACKGROUND: Patients with prior Roux-en-Y gastric bypass (RYGB) operations for weight loss present reconstruction challenges during a pancreaticoduodenectomy (PD). With over 60,000 RYGB performed annually, the increasing odds of encountering such patients during a PD make it imperative to understand the RYGB anatomy and anticipate reconstruction options. This article describes the possible reconstruction options and their rationale. METHODS: We reviewed our PD reconstruction options, compared them to what have been described in the literature, and derived a consensus from internal conferences comprising bariatric and hepatopancreatobiliary surgeons to describe known reconstruction options...
June 13, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28608844/the-recreov%C3%A3-a-of-bogot%C3%A3-a-community-based-physical-activity-program-to-promote-physical-activity-among-women-baseline-results-of-the-natural-experiment-al-ritmo-de-las-comunidades
#11
Olga L Sarmiento, Ana Paola Rios, Diana C Paez, Karoll Quijano, Rogério César Fermino
Community-based physical activity (PA) programs in Latin America have been recognized because of the use of available environmental resources to offer PA classes. Yet, the evaluation of programs focused on PA classes involving dancing in public spaces is limited. The aim of this study was to assess the physical activity levels, park use, and the contextual characteristics of public parks with and without the Recreovía in Bogotá in Colombia. Al Ritmo de las Comunidades is a natural experiment conducted in nine parks (3 parks implementing new Recreovías, 3 control parks and 3 parks with existing Recreovías) during 2013...
June 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28607193/hydrogen-embrittlement-the-game-changing-factor-in-the-applicability-of-nickel-alloys-in-oilfield-technology
#12
Helmuth Sarmiento Klapper, Jutta Klöwer, Olesya Gosheva
Precipitation hardenable (PH) nickel (Ni) alloys are often the most reliable engineering materials for demanding oilfield upstream and subsea applications especially in deep sour wells. Despite their superior corrosion resistance and mechanical properties over a broad range of temperatures, the applicability of PH Ni alloys has been questioned due to their susceptibility to hydrogen embrittlement (HE), as confirmed in documented failures of components in upstream applications. While extensive work has been done in recent years to develop testing methodologies for benchmarking PH Ni alloys in terms of their HE susceptibility, limited scientific research has been conducted to achieve improved foundational knowledge about the role of microstructural particularities in these alloys on their mechanical behaviour in environments promoting hydrogen uptake...
July 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28583338/distal-corporal-anchoring-stitch-a-technique-to-address-distal-corporal-crossovers-and-impending-lateral-extrusions-of-a-penile-prosthesis
#13
Gabriele Antonini, Gian Maria Busetto, Francesco Del Giudice, Matteo Ferro, Benjamin I Chung, Simon L Conti, Alfredo Suarez Sarmiento, Arianna Pacchiarotti, Ettore De Berardinis, Paul E Perito
BACKGROUND: Unidentified distal crossovers, delayed distal crossovers, and impending lateral extrusion are complications of penile prosthesis implant insertion but are not as common as prosthesis infection or mechanical failure. AIM: To evaluate results of a surgical technique, the distal corporal anchoring stitch, that addresses fixation of the penile prosthesis in patients with these complications. METHODS: A lateral sub-coronal incision is used on the side where the crossover or laterally extruding cylinder should be positioned...
June 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28581445/glutamine-supplementation-suppresses-herpes-simplex-virus-reactivation
#14
Kening Wang, Yo Hoshino, Kennichi Dowdell, Marta Bosch-Marce, Timothy G Myers, Mayra Sarmiento, Lesley Pesnicak, Philip R Krause, Jeffrey I Cohen
Chronic viral infections are difficult to treat, and new approaches are needed, particularly those aimed at reducing reactivation by enhancing immune responses. Herpes simplex virus (HSV) establishes latency and reactivates frequently, and breakthrough reactivation can occur despite suppressive antiviral therapy. Virus-specific T cells are important to control HSV, and proliferation of activated T cells requires increased metabolism of glutamine. Here, we found that supplementation with oral glutamine reduced virus reactivation in latently HSV-1-infected mice and HSV-2-infected guinea pigs...
June 5, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28579748/functional-characterization-of-rs2229094-t-c-polymorphism-in-the-tumor-necrosis-factor-locus-and-lymphotoxin-alpha-expression-in-human-retina-the-retina-4-project
#15
Salvador Pastor-Idoate, Irene Rodríguez-Hernández, Jimena Rojas, Lucia Gonzalez-Buendia, Santiago Delgado-Tirado, Jose Carlos López, Rogelio González-Sarmiento, Jose C Pastor
PURPOSE: The objective of this study is to determine the expression and localization of lymphotoxin alpha (LTA) in human retinas and the functionality of one of its polymorphisms rs2229094 (C13R) (T>C), previously associated with proliferative vitreoretinopathy (PVR) development. MATERIALS AND METHODS: Total RNA from three healthy human retinas were extracted and subjected to reverse transcription-polymerase chain reaction (RT-PCR) analysis, using flanking primers of LTA cDNA...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28560033/comparison-of-outcome-of-vlcp-versus-pkef-in-the-treatment-of-ao-type-c2-3-distal-radial-fractures
#16
Zhibing Tang, Jinlian Liu, Huilin Yang
PURPOSES: Fractures of the distal radius are extremely common in adults. However, the optimal management remains controversial, especially in AO type C2-3 (Type23 C2 or C3 of distal radial fracture, according to AO classifications). The purpose of this study was to compare the results of the volar locking compression plate (VLCP) and percutaneous Kirschner-wires combined with external fixation (PKEF) in the treatment of the AO type C2-3 fractures. METHODS: From July 2012 to June 2015, 62 patients with AO type C2-3 fractures, treated by VLCP or PKEF, were included in this retrospective study...
June 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28555522/compositional-data-analysis-for-physical-activity-sedentary-time-and-sleep-research
#17
Dorothea Dumuid, Tyman E Stanford, Josep-Antoni Martin-Fernández, Željko Pedišić, Carol A Maher, Lucy K Lewis, Karel Hron, Peter T Katzmarzyk, Jean-Philippe Chaput, Mikael Fogelholm, Gang Hu, Estelle V Lambert, José Maia, Olga L Sarmiento, Martyn Standage, Tiago V Barreira, Stephanie T Broyles, Catrine Tudor-Locke, Mark S Tremblay, Timothy Olds
The health effects of daily activity behaviours (physical activity, sedentary time and sleep) are widely studied. While previous research has largely examined activity behaviours in isolation, recent studies have adjusted for multiple behaviours. However, the inclusion of all activity behaviours in traditional multivariate analyses has not been possible due to the perfect multicollinearity of 24-h time budget data. The ensuing lack of adjustment for known effects on the outcome undermines the validity of study findings...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28553957/genetic-association-study-of-exfoliation-syndrome-identifies-a-protective-rare-variant-at-loxl1-and-five-new-susceptibility-loci
#18
Tin Aung, Mineo Ozaki, Mei Chin Lee, Ursula Schlötzer-Schrehardt, Gudmar Thorleifsson, Takanori Mizoguchi, Robert P Igo, Aravind Haripriya, Susan E Williams, Yury S Astakhov, Andrew C Orr, Kathryn P Burdon, Satoko Nakano, Kazuhiko Mori, Khaled Abu-Amero, Michael Hauser, Zheng Li, Gopalakrishnan Prakadeeswari, Jessica N Cooke Bailey, Alina Popa Cherecheanu, Jae H Kang, Sarah Nelson, Ken Hayashi, Shin-Ichi Manabe, Shigeyasu Kazama, Tomasz Zarnowski, Kenji Inoue, Murat Irkec, Miguel Coca-Prados, Kazuhisa Sugiyama, Irma Järvelä, Patricio Schlottmann, S Fabian Lerner, Hasnaa Lamari, Yildirim Nilgün, Mukharram Bikbov, Ki Ho Park, Soon Cheol Cha, Kenji Yamashiro, Juan C Zenteno, Jost B Jonas, Rajesh S Kumar, Shamira A Perera, Anita S Y Chan, Nino Kobakhidze, Ronnie George, Lingam Vijaya, Tan Do, Deepak P Edward, Lourdes de Juan Marcos, Mohammad Pakravan, Sasan Moghimi, Ryuichi Ideta, Daniella Bach-Holm, Per Kappelgaard, Barbara Wirostko, Samuel Thomas, Daniel Gaston, Karen Bedard, Wenda L Greer, Zhenglin Yang, Xueyi Chen, Lulin Huang, Jinghong Sang, Hongyan Jia, Liyun Jia, Chunyan Qiao, Hui Zhang, Xuyang Liu, Bowen Zhao, Ya-Xing Wang, Liang Xu, Stéphanie Leruez, Pascal Reynier, George Chichua, Sergo Tabagari, Steffen Uebe, Matthias Zenkel, Daniel Berner, Georg Mossböck, Nicole Weisschuh, Ursula Hoja, Ulrich-Christoph Welge-Luessen, Christian Mardin, Panayiota Founti, Anthi Chatzikyriakidou, Theofanis Pappas, Eleftherios Anastasopoulos, Alexandros Lambropoulos, Arkasubhra Ghosh, Rohit Shetty, Natalia Porporato, Vijayan Saravanan, Rengaraj Venkatesh, Chandrashekaran Shivkumar, Narendran Kalpana, Sripriya Sarangapani, Mozhgan R Kanavi, Afsaneh Naderi Beni, Shahin Yazdani, Alireza Lashay, Homa Naderifar, Nassim Khatibi, Antonio Fea, Carlo Lavia, Laura Dallorto, Teresa Rolle, Paolo Frezzotti, Daniela Paoli, Erika Salvi, Paolo Manunta, Yosai Mori, Kazunori Miyata, Tomomi Higashide, Etsuo Chihara, Satoshi Ishiko, Akitoshi Yoshida, Masahide Yanagi, Yoshiaki Kiuchi, Tsutomu Ohashi, Toshiya Sakurai, Takako Sugimoto, Hideki Chuman, Makoto Aihara, Masaru Inatani, Masahiro Miyake, Norimoto Gotoh, Fumihiko Matsuda, Nagahisa Yoshimura, Yoko Ikeda, Morio Ueno, Chie Sotozono, Jin Wook Jeoung, Min Sagong, Kyu Hyung Park, Jeeyun Ahn, Marisa Cruz-Aguilar, Sidi M Ezzouhairi, Abderrahman Rafei, Yaan Fun Chong, Xiao Yu Ng, Shuang Ru Goh, Yueming Chen, Victor H K Yong, Muhammad Imran Khan, Olusola O Olawoye, Adeyinka O Ashaye, Idakwo Ugbede, Adeola Onakoya, Nkiru Kizor-Akaraiwe, Chaiwat Teekhasaenee, Yanin Suwan, Wasu Supakontanasan, Suhanya Okeke, Nkechi J Uche, Ifeoma Asimadu, Humaira Ayub, Farah Akhtar, Ewa Kosior-Jarecka, Urszula Lukasik, Ignacio Lischinsky, Vania Castro, Rodolfo Perez Grossmann, Gordana Sunaric Megevand, Sylvain Roy, Edward Dervan, Eoin Silke, Aparna Rao, Priti Sahay, Pablo Fornero, Osvaldo Cuello, Delia Sivori, Tamara Zompa, Richard A Mills, Emmanuelle Souzeau, Paul Mitchell, Jie Jin Wang, Alex W Hewitt, Michael Coote, Jonathan G Crowston, Sergei Y Astakhov, Eugeny L Akopov, Anton Emelyanov, Vera Vysochinskaya, Gyulli Kazakbaeva, Rinat Fayzrakhmanov, Saleh A Al-Obeidan, Ohoud Owaidhah, Leyla Ali Aljasim, Balram Chowbay, Jia Nee Foo, Raphael Q Soh, Kar Seng Sim, Zhicheng Xie, Augustine W O Cheong, Shi Qi Mok, Hui Meng Soo, Xiao Yin Chen, Su Qin Peh, Khai Koon Heng, Rahat Husain, Su-Ling Ho, Axel M Hillmer, Ching-Yu Cheng, Francisco A Escudero-Domínguez, Rogelio González-Sarmiento, Frederico Martinon-Torres, Antonio Salas, Kessara Pathanapitoon, Linda Hansapinyo, Boonsong Wanichwecharugruang, Naris Kitnarong, Anavaj Sakuntabhai, Hip X Nguyn, Giang T T Nguyn, Trình V Nguyn, Werner Zenz, Alexander Binder, Daniela S Klobassa, Martin L Hibberd, Sonia Davila, Stefan Herms, Markus M Nöthen, Susanne Moebus, Robyn M Rautenbach, Ari Ziskind, Trevor R Carmichael, Michele Ramsay, Lydia Álvarez, Montserrat García, Héctor González-Iglesias, Pedro P Rodríguez-Calvo, Luis Fernández-Vega Cueto, Çilingir Oguz, Nevbahar Tamcelik, Eray Atalay, Bilge Batu, Dilek Aktas, Burcu Kasım, M Roy Wilson, Anne L Coleman, Yutao Liu, Pratap Challa, Leon Herndon, Rachel W Kuchtey, John Kuchtey, Karen Curtin, Craig J Chaya, Alan Crandall, Linda M Zangwill, Tien Yin Wong, Masakazu Nakano, Shigeru Kinoshita, Anneke I den Hollander, Eija Vesti, John H Fingert, Richard K Lee, Arthur J Sit, Bradford J Shingleton, Ningli Wang, Daniele Cusi, Raheel Qamar, Peter Kraft, Margaret A Pericak-Vance, Soumya Raychaudhuri, Steffen Heegaard, Tero Kivelä, André Reis, Friedrich E Kruse, Robert N Weinreb, Louis R Pasquale, Jonathan L Haines, Unnur Thorsteinsdottir, Fridbert Jonasson, R Rand Allingham, Dan Milea, Robert Ritch, Toshiaki Kubota, Kei Tashiro, Eranga N Vithana, Shazia Micheal, Fotis Topouzis, Jamie E Craig, Michael Dubina, Periasamy Sundaresan, Kari Stefansson, Janey L Wiggs, Francesca Pasutto, Chiea Chuen Khor
Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A, have previously been associated with XFS. To further elucidate the genetic basis of XFS, we collected a global sample of XFS cases to refine the association at LOXL1, which previously showed inconsistent results across populations, and to identify new variants associated with XFS. We identified a rare protective allele at LOXL1 (p.Phe407, odds ratio (OR) = 25, P = 2...
May 29, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28549556/evaluation-of-a-commercial-automatic-treatment-planning-system-for-prostate-cancers
#19
Kanabu Nawa, Akihiro Haga, Akihiro Nomoto, Raniel A Sarmiento, Kenshiro Shiraishi, Hideomi Yamashita, Keiichi Nakagawa
Recent developments in Radiation Oncology treatment planning have led to the development of software packages that facilitate automated intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) planning. Such solutions include site-specific modules, plan library methods, and algorithm-based methods. In this study, the plan quality for prostate cancer generated by the Auto-Planning module of the Pinnacle(3) radiation therapy treatment planning system (v9.10, Fitchburg, WI) is retrospectively evaluated...
May 23, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28544991/associations-of-neighborhood-social-environment-attributes-and-physical-activity-among-9-11-year-old-children-from-12-countries
#20
Samaah M Sullivan, Stephanie T Broyles, Tiago V Barreira, Jean-Philippe Chaput, Mikael Fogelholm, Gang Hu, Rebecca Kuriyan, Anura Kurpad, Estelle V Lambert, Carol Maher, Jose Maia, Victor Matsudo, Tim Olds, Vincent Onywera, Olga L Sarmiento, Martyn Standage, Mark S Tremblay, Catrine Tudor-Locke, Pei Zhao, Peter T Katzmarzyk
We investigated whether associations of neighborhood social environment attributes and physical activity differed among 12 countries and levels of economic development using World Bank classification (low/lower-middle-, upper-middle- and high- income countries) among 9-11 year old children (N=6161) from the International Study of Childhood Obesity, Lifestyle, and the Environment (ISCOLE). Collective efficacy and perceived crime were obtained via parental/guardian report. Moderate-to-vigorous physical activity (MVPA) was assessed with waist-worn Actigraph accelerometers...
May 22, 2017: Health & Place
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