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https://www.readbyqxmd.com/read/29335401/author-correction-spiraling-pathways-of-global-deep-waters-to-the-surface-of-the-southern-ocean
#1
Veronica Tamsitt, Henri F Drake, Adele K Morrison, Lynne D Talley, Carolina O Dufour, Alison R Gray, Stephen M Griffies, Matthew R Mazloff, Jorge L Sarmiento, Jinbo Wang, Wilbert Weijer
The original version of this Article contained errors in Fig. 6. In panel a, the grey highlights obscured the curves for CESM, CM2.6 and SOSE, and the labels indicating SWIR, KP, MR, PAR, and DP were inadvertently omitted. These have now been corrected in both the PDF and HTML versions of the Article.
January 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29332686/no-evidence-for-an-epidemiological-transition-in-sleep-patterns-among-children-a-12-country-study
#2
Taru Manyanga, Joel D Barnes, Mark S Tremblay, Peter T Katzmarzyk, Stephanie T Broyles, Tiago V Barreira, Mikael Fogelholm, Gang Hu, Carol Maher, Jose Maia, Timothy Olds, Olga L Sarmiento, Martyn Standage, Catrine Tudor-Locke, Jean-Philippe Chaput
OBJECTIVE: To examine the relationships between socioeconomic status (SES; household income and parental education) and objectively measured sleep patterns (sleep duration, sleep efficiency, and bedtime) among children from around the world and explore how the relationships differ across country levels of human development. DESIGN: Multinational, cross-sectional study from sites in Australia, Brazil, Canada, China, Colombia, Finland, India, Kenya, Portugal, South Africa, the United Kingdom, and the United States...
February 2018: Sleep Health
https://www.readbyqxmd.com/read/29297134/tamoxifen-induces-apoptotic-neutrophil-efferocytosis-in-horses
#3
C Olave, N Morales, B Uberti, C Henriquez, J Sarmiento, A Ortloff, H Folch, G Moran
Macrophages and neutrophils are important cellular components in the process of acute inflammation and its subsequent resolution, and evidence increasingly suggests that they play important functions during the resolution of chronic, adaptive inflammatory processes. Exacerbated neutrophil activity can be harmful to surrounding tissues; this is important in a range of diseases, including allergic asthma and chronic obstructive pulmonary disease in humans, and equine asthma (also known as recurrent airway obstruction (RAO)...
January 2, 2018: Veterinary Research Communications
https://www.readbyqxmd.com/read/29290808/dosimetric-evaluation-of-radionuclides-for-vcam-1-targeted-radionuclide-therapy-of-early-brain-metastases
#4
Nadia Falzone, Nicole L Ackerman, Liset de la Fuente Rosales, Mario A Bernal, Xiaoxuan Liu, Sarah Gja Peeters, Manuel Sarmiento Soto, Aurélien Corroyer-Dulmont, Myriam Bernaudin, Elisa Grimoin, Omar Touzani, Nicola R Sibson, Katherine A Vallis
Brain metastases develop frequently in patients with breast cancer, and present a pressing therapeutic challenge. Expression of vascular cell adhesion molecule 1 (VCAM-1) is upregulated on brain endothelial cells during the early stages of metastasis and provides a target for the detection and treatment of early brain metastases. The aim of this study was to use a model of early brain metastasis to evaluate the efficacy of α-emitting radionuclides, 149Tb, 211At, 212Pb, 213Bi and 225Ac; β-emitting radionuclides, 90Y, 161Tb and 177Lu; and Auger electron (AE)-emitters 67Ga, 89Zr, 111In and 124I, for targeted radionuclide therapy (TRT)...
2018: Theranostics
https://www.readbyqxmd.com/read/29279773/automatic-cdr-estimation-for-early-glaucoma-diagnosis
#5
M A Fernandez-Granero, A Sarmiento, D Sanchez-Morillo, S Jiménez, P Alemany, I Fondón
Glaucoma is a degenerative disease that constitutes the second cause of blindness in developed countries. Although it cannot be cured, its progression can be prevented through early diagnosis. In this paper, we propose a new algorithm for automatic glaucoma diagnosis based on retinal colour images. We focus on capturing the inherent colour changes of optic disc (OD) and cup borders by computing several colour derivatives in CIE L∗a∗b∗ colour space with CIE94 colour distance. In addition, we consider spatial information retaining these colour derivatives and the original CIE L∗a∗b∗ values of the pixel and adding other characteristics such as its distance to the OD centre...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29275168/molecular-analysis-of-thyroglobulin-mutations-found-in-patients-with-goiter-and-hypothyroidism
#6
Sofia Siffo, Ezequiela Adrover, Cintia E Citterio, Mirta B Miras, Viviana A Balbi, Ana Chiesa, Jacques Weill, Gabriela Sobrero, Verónica G González, Patricia Papendieck, Elena Bueno Martinez, Rogelio Gonzalez-Sarmiento, Carina M Rivolta, Héctor M Targovnik
Thyroid dyshormonogenesis due to thyroglobulin (TG) gene mutations have an estimated incidence of approximately 1 in 100,000 newborns. The clinical spectrum ranges from euthyroid to mild or severe hypothyroidism. Up to now, one hundred seventeen deleterious mutations in the TG gene have been identified and characterized. The purpose of the present study was to identify and characterize new mutations in the TG gene. We report eight patients from seven unrelated families with goiter, hypothyroidism and low levels of serum TG...
December 22, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29261159/a-rare-case-of-pure-erythroid-sarcoma-in-a-pediatric-patient-case-report-and-literature-review
#7
Pablo Manresa, Fabián Tarín, María Niveiro, María Tasso, Olga Alda, Francisco López, Héctor Sarmiento, José J Verdú, Francisco De Paz, Silvia López, María Del Cañizo, Esperanza Such, Eva Barragán, Fernanda Martirena
We describe an exceptional case of erythroid sarcoma in a pediatric patient as a growing orbital mass with no evidence of morphologic bone marrow involvement, who was finally diagnosed of pure erythroid sarcoma based on histopathology and flow cytometry criteria. We discuss the contribution of standardized eight-color flow cytometry as a rapid and reliable diagnostic method. The use of normal bone marrow databases allowed us to identify small aberrant populations in bone marrow and later confirm the diagnosis in the neoplastic tissue...
December 20, 2017: Children
https://www.readbyqxmd.com/read/29241561/arabidopsis-mterf6-is-required-for-leaf-patterning
#8
Pedro Robles, Eva Núñez-Delegido, Almudena Ferrández-Ayela, Raquel Sarmiento-Mañús, José Luis Micol, Víctor Quesada
To enhance our understanding of the roles of mitochondrial transcription termination factors (mTERFs) in plants, we have taken a reverse genetic approach in Arabidopsis thaliana. One of the mutants isolated carried a novel allele of the mTERF6 gene, which we named mterf6-5. mTERF6 is a chloroplast and mitochondrial localised protein required for the maturation of chloroplast isoleucine tRNA. The mterf6-5 plants are pale and exhibit markedly reduced growth, and altered leaf and chloroplast development. Our qRT-PCR analyses revealed mis-expression of several plastid, mitochondrial and nuclear genes in mterf6-5 plants...
January 2018: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29233635/therapeutic-benefit-of-environmental-enrichment-on-optic-neuritis
#9
REVIEW
Marcos L Aranda, María F González Fleitas, Hernán H Dieguez, Georgia A Milne, Julián D Devouassoux, María I Keller Sarmiento, Mónica Chianelli, Pablo H Sande, Damián Dorfman, Ruth E Rosenstein
Optic neuritis (ON) is an inflammatory, demyelinating, neurodegenerative, and presently untreatable condition of the optic nerve which might induce blindness. We analyzed the effect of environmental enrichment (EE) on visual pathway damage provoked by experimental ON induced by a microinjection of bacterial lipopolysaccharide (LPS) into the optic nerve. For this purpose, LPS was microinjected into the optic nerve from male Wistar rats. After injection, one group of animals was submitted to EE, and another group remained in standard environment (SE) for 21 days...
December 9, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29223790/temporal-and-bi-directional-associations-between-sleep-duration-and-physical-activity-sedentary-time-in-children-an-international-comparison
#10
Yingyi Lin, Mark S Tremblay, Peter T Katzmarzyk, Mikael Fogelholm, Gang Hu, Estelle V Lambert, Carol Maher, Jose Maia, Timothy Olds, Olga L Sarmiento, Martyn Standage, Catrine Tudor-Locke, Jean-Philippe Chaput
The purpose of this multinational and cross-sectional study was to investigate whether nighttime sleep duration was associated with physical activity (PA) and sedentary time (SED) the following day, whether daytime PA/SED were associated with sleep duration the subsequent night, and whether the associations were modified by sex and study sites. Data from 5779 children aged 9-11years were analyzed. A waist-worn Actigraph GT3X+ accelerometer was used to assess children's 24-h movement behaviours for 7days, i...
December 7, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29221125/tctn2-a-novel-tumor-marker-with-oncogenic-properties
#11
David Cano-Rodriguez, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Elisa De Camilli, Chaojun Song, Boquan Jin, Aurelien Lacombe, Andrea Pierleoni, Mauro Bombaci, Chiara Cordiglieri, Marcel Hj Ruiters, Giuseppe Viale, Luigi Terracciano, Paolo Sarmientos, Sergio Abrignani, Guido Grandi, Piero Pileri, Marianne G Rots, Renata Grifantini
Tectonic family member 2 (TCTN2) encodes a transmembrane protein that belongs to the tectonic family, which is involved in ciliary functions. Previous studies have demonstrated the role of tectonics in regulating a variety of signaling pathways at the transition zone of cilia. However, the role of tectonics in cancer is still unclear. Here we identify that TCTN2 is overexpressed in colorectal, lung and ovary cancers. We show that different cancer cell lines express the protein that localizes at the plasma membrane, facing the intracellular milieu...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29215297/virulence-genes-and-antimicrobial-resistance-in-escherichia-coli-from-cheese-made-from-unpasteurized-milk-in-brazil
#12
Anna C L P de Campos, Juan J Puño-Sarmiento, Leonardo P Medeiros, Luís E S Gazal, Renato Pariz Maluta, Armando Navarro, Renata K T Kobayashi, Eder P Fagan, Gerson Nakazato
Cow raw milk cheese is widely eaten in Brazil. These products may be contaminated with pathogenic bacteria. In this work, we investigated the presence of Escherichia coli in raw milk cheese from different States in Brazil. From 147 "Minas" cheese samples, 28 cheeses were positive for E. coli. Among 39 E. coli isolates of the cheeses, one was positive for eae and negative for bpfA and efa1/lifA using PCR, and so was classified as atypical Enteropathogenic E. coli (aEPEC). Two other isolates were positive for extraintestinal pathogenic E...
December 7, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29214116/compassionate-use-of-ruxolitinib-in-acute-and-chronic-graft-versus-host-disease-refractory-both-to-corticosteroids-and-extracorporeal-photopheresis
#13
Mauricio Sarmiento Maldonado, Pablo Ramírez Villanueva, Pablo Bertín Cortes-Monroy, Veronica Jara Arias, Katherine Soto Donoso, Pablo Uribe Gonzalez, Mauricio Ocqueteau Tachini, Jose Antonio Perez-Simón
Background: Ruxolitinib is a potent inhibitor of JAK1/2 with proven efficacy in myelofibrosis. In recent years, research in graft versus host disease (GVHD) has revealed the role of activation of JAK pathways in alloreactive lymphocytes. Some reports have shown significant responses in refractory GVHD patients. Cases presentation: In this report we present our experience in 8 patients with acute or chronic GVHD with refractoriness to steroids and extracorporeal photopheresis treated with ruxolitinib...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29203005/steadi-cdc-s-approach-to-make-older-adult-fall-prevention-part-of-every-primary-care-practice
#14
Kelly Sarmiento, Robin Lee
INTRODUCTION: Primary care providers play a critical role in protecting older adult patients from one of the biggest threats to their health and independence-falls. A fall among an older adult patient cannot only be fatal or cause a devastating injury, but can also lead to problems that can effect a patient's overall quality of life. METHODS: In response, the Centers for Disease Control and Prevention (CDC) developed the STEADI initiative to give health care providers the tools they need to help reduce their older adult patient's risk of a fall...
December 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/29184164/correlates-of-compliance-with-recommended-levels-of-physical-activity-in-children
#15
Thayse Natacha Gomes, Peter T Katzmarzyk, Donald Hedeker, Mikael Fogelholm, Martyn Standage, Vincent Onywera, Estelle V Lambert, Mark S Tremblay, Jean-Philippe Chaput, Catrine Tudor-Locke, Olga Sarmiento, Victor Matsudo, Anura Kurpad, Rebecca Kuriyan, Pei Zhao, Gang Hu, Timothy Olds, Carol Maher, José Maia
The purpose of this study was to describe children's daily compliance with moderate-to-vigorous physical activity (MVPA) recommendations across a week in different parts of the world, and to identify individual- and school-level correlates that may explain differences in daily MVPA compliance. The sample included 6553 children aged 9-11 years from 12 countries, and multilevel statistical analyses were used, including both child- and school-level variables. Most children did not comply with the MVPA guidelines on a daily basis: Chinese children complied the least, whereas Finnish, Australian, Colombian, UK, and Kenyan children complied the most...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29171632/-acute-lymphoblastic-leukemia-causing-hepatic-failure-report-of-two-cases
#16
Muriel Catalá, Mauricio Ocqueteau T, Mauricio Sarmiento M
No abstract text is available yet for this article.
June 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29170203/identification-of-a-novel-locus-on-chromosome-2q13-which-predisposes-to-clinical-vertebral-fractures-independently-of-bone-density
#17
Nerea Alonso, Karol Estrada, Omar M E Albagha, Lizbeth Herrera, Sjur Reppe, Ole K Olstad, Kaare M Gautvik, Niamh M Ryan, Kathryn L Evans, Carrie M Nielson, Yi-Hsiang Hsu, Douglas P Kiel, George Markozannes, Evangelia E Ntzani, Evangelos Evangelou, Bjarke Feenstra, Xueping Liu, Mads Melbye, Laura Masi, Maria Luisa Brandi, Philip Riches, Anna Daroszewska, José Manuel Olmos, Carmen Valero, Jesús Castillo, José A Riancho, Lise B Husted, Bente L Langdahl, Matthew A Brown, Emma L Duncan, Stephen Kaptoge, Kay-Tee Khaw, Ricardo Usategui-Martín, Javier Del Pino-Montes, Rogelio González-Sarmiento, Joshua R Lewis, Richard L Prince, Patrizia D'Amelio, Natalia García-Giralt, Xavier Nogués, Simona Mencej-Bedrac, Janja Marc, Orit Wolstein, John A Eisman, Ling Oei, Carolina Medina-Gómez, Katharina E Schraut, Pau Navarro, James F Wilson, Gail Davies, John Starr, Ian Deary, Toshiko Tanaka, Luigi Ferrucci, Fernando Gianfrancesco, Luigi Gennari, Gavin Lucas, Roberto Elosua, André G Uitterlinden, Fernando Rivadeneira, Stuart H Ralston
OBJECTIVES: To identify genetic determinants of susceptibility to clinical vertebral fractures, which is an important complication of osteoporosis. METHODS: Here we conduct a genome-wide association study in 1553 postmenopausal women with clinical vertebral fractures and 4340 controls, with a two-stage replication involving 1028 cases and 3762 controls. Potentially causal variants were identified using expression quantitative trait loci (eQTL) data from transiliac bone biopsies and bioinformatic studies...
November 23, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29164051/anti-inflammatory-microglia-macrophages-as-a-potential-therapeutic-target-in-brain-metastasis
#18
Kleopatra E Andreou, Manuel Sarmiento Soto, Danny Allen, Vasiliki Economopoulos, Axel de Bernardi, James R Larkin, Nicola R Sibson
Brain metastasis is a common complication of cancer patients and is associated with poor survival. Histological data from patients with brain metastases suggest that microglia are the major immune population activated around the metastatic foci. Microglia and macrophages have the ability to polarize to different phenotypes and to exert both tumorigenic and cytotoxic effects. However, the role of microglia/macrophages during the early stages of metastatic growth in the brain has not yet been determined. The aim of this study was to profile microglial/macrophage activation in a mouse model of breast cancer brain metastasis during the early stages of tumor growth, and to assess the role of the anti-inflammatory microglial/macrophage population, specifically, during this phase...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29161476/-spatial-distribution-of-aedes-aegypti-diptera-culicidae-in-the-rural-area-of-two-municipalities-of-cundinamarca-colombia
#19
Laura Cabezas, Wilson Cabanzo, Fernando Santa, Victor Alberto Olano, Diana Sarmiento, Sandra Vargas, Juan Felipe Jaramillo, Thor-Axel Stenstrom, Hans J Overgaard, María Inés Matiz
INTRODUCTION: It is difficult to adapt or create new strategies for dengue control in rural areas due to the dispersion of homes and the lack of knowledge about the presence and behavior of the vector in these areas. Spatial data analysis could help understand time and space dynamics related to the transmission of vector-borne diseases in rural areas and, thus, contribute to the prevention and control of dengue. OBJECTIVE: To determine the probability of the presence of the dengue vector Aedes aegypti in the rural area of the municipalities of Anapoima and La Mesa, in the central area of Colombia...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29152784/workplace-violence-injury-in-106-us-hospitals-participating-in-the-occupational-health-safety-network-ohsn-2012-2015
#20
Matthew R Groenewold, Raymond F R Sarmiento, Kelly Vanoli, William Raudabaugh, Susan Nowlin, Ahmed Gomaa
BACKGROUND: Workplace violence is a substantial occupational hazard for healthcare workers in the United States. METHODS: We analyzed workplace violence injury surveillance data submitted by hospitals participating in the Occupational Health Safety Network (OHSN) from 2012 to 2015. RESULTS: Data were frequently missing for several important variables. Nursing assistants (14.89, 95%CI 10.12-21.91) and nurses (8.05, 95%CI 6.14-10.55) had the highest crude workplace violence injury rates per 1000 full-time equivalent (FTE) workers...
November 20, 2017: American Journal of Industrial Medicine
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