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https://www.readbyqxmd.com/read/28416736/nomo-1-gene-is-deleted-in-early-onset-colorectal-cancer
#1
José Perea, Juan Luis García, Jessica Pérez, Daniel Rueda, María Arriba, Yolanda Rodríguez, Miguel Urioste, Rogelio González-Sarmiento
To characterize clinical features of a recurrent alteration in 16p13.12-p13.11 in Colorectal Cancer (CRC), mainly in Early-onset subgroup (EOCRC), and to assess the status of NOMO1, a gene located in that region, we analyzed differential clinicopathological, familial and molecular features of CRC subsets with and without alterations in the 16p13.12-p13.11, in global and EOCRC groups. We confirmed the region by fluorescence in-situ hybridization, and Quantitative Real-Time PCR analyzed the status of NOMO1 in different age-of-onset and Microsatellite Instability (MSI)-status CRC subsets...
February 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28353133/automatic-recognition-of-severity-level-for-diagnosis-of-diabetic-retinopathy-using-deep-visual-features
#2
Qaisar Abbas, Irene Fondon, Auxiliadora Sarmiento, Soledad Jiménez, Pedro Alemany
Diabetic retinopathy (DR) is leading cause of blindness among diabetic patients. Recognition of severity level is required by ophthalmologists to early detect and diagnose the DR. However, it is a challenging task for both medical experts and computer-aided diagnosis systems due to requiring extensive domain expert knowledge. In this article, a novel automatic recognition system for the five severity level of diabetic retinopathy (SLDR) is developed without performing any pre- and post-processing steps on retinal fundus images through learning of deep visual features (DVFs)...
March 28, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28339363/proangiogenic-gene-polymorphisms-are-associated-with-susceptibility-to-paget-s-disease-of-bone-and-with-its-clinical-features
#3
Ismael Calero-Paniagua, Ricardo Usategui-Martín, Luís Corral-Gudino, Judit García-Aparicio, Javier Del Pino-Montes, Rogelio González-Sarmiento
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March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28320422/do-associations-between-objectively-assessed-physical-activity-and-neighbourhood-environment-attributes-vary-by-time-of-the-day-and-day-of-the-week-ipen-adult-study
#4
Ester Cerin, Josef Mitáš, Kelli L Cain, Terry L Conway, Marc A Adams, Grant Schofield, Olga L Sarmiento, Rodrigo Siqueira Reis, Jasper Schipperijn, Rachel Davey, Deborah Salvo, Rosario Orzanco-Garralda, Duncan J Macfarlane, Ilse De Bourdeaudhuij, Neville Owen, James F Sallis, Delfien Van Dyck
BACKGROUND: To more accurately quantify the potential impact of the neighbourhood environment on adults' physical activity (PA), it is important to compare environment-PA associations between periods of the day or week when adults are more versus less likely to be in their neighbourhood and utilise its PA resources. We examined whether, among adults from 10 countries, associations between objectively-assessed neighbourhood environment attributes and moderate-to-vigorous physical activity (MVPA) varied by time of the day and day of the week...
March 20, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28279167/novel-snp-markers-in-invge-and-sssi-genes-are-associated-with-natural-variation-of-sugar-contents-and-frying-color-in-solanum-tuberosum-group-phureja
#5
Diana Duarte-Delgado, Deissy Juyó, Christiane Gebhardt, Felipe Sarmiento, Teresa Mosquera-Vásquez
BACKGROUND: Potato frying color is an agronomic trait influenced by the sugar content of tubers. The candidate gene approach was employed to elucidate the molecular basis of this trait in Solanum tuberosum Group Phureja, which is mainly diploid and represents an important genetic resource for potato breeding. The objective of this research was to identify novel genetic variants related with frying quality in loci with key functions in carbohydrate metabolism, with the purpose of discovering genetic variability useful in breeding programs...
March 9, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28274010/radiological-outcomes-of-distal-radius-fractures-managed-with-2-7mm-volar-locking-plate-fixation-a-retrospective-analysis
#6
Prem Kotian, Srikanth Mudiganty, Rajendra Annappa, Jose Austine
INTRODUCTION: Distal radius fractures accounts for around 15% of all fractures diagnosed and treated in the emergency rooms. These fractures usually result secondary to high velocity injury such as a motor vehicle accident or fall on an out stretched hand. In the elderly, it is a common fragility fracture. Volar Locking Compression Plates (LCP) is effective devices for fixation of the distal radius fractures. There is a lacuna with regard to literature on the 2.7 mm volar LCP and the current study retrospectively assesses the postoperative radiological outcomes...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28274009/unstable-distal-radius-fractures-treated-by-volar-locking-anatomical-plates
#7
Anto Jose, Shishir Murugharaj Suranigi, Pascal Noel Deniese, Abey Thomas Babu, Kanagasabai Rengasamy, Syed Najimudeen
INTRODUCTION: Fracture of the distal end of radius represents the most common fracture of the upper extremity accounting for 16-20% of all fractures. Plating is now emerging as the gold standard for management of distal radius fractures due to increased rate of complications such as malunion, subluxation/dislocation of distal radio-ulnar joint or late collapse of fracture. Procedures such as closed reduction and cast immobilization, ligamentotaxis with external fixator and percutaneous pin fixation are no longer acceptable...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28269230/auto-adjusting-mandibular-repositioning-device-for-in-home-use
#8
R Brugarolas, J M Valero-Sarmiento, A Bozkurt, G K Essick
Obstructive Sleep Apnea (OSA) is a form of respiratory dysfunction that affects 20% of adults in the world. Among the first-line treatments that are used to mitigate the effects of OSA are continuous positive airway pressure (CPAP) and mandibular repositioning devices (MRD). Although CPAP provides a more efficacious therapy than MRDs, recent studies suggest that both are comparable in overall effectiveness due to greater patient preference and adherence to MRD therapy. In this paper, we present the Auto-Positioner, a novel add-on for MRDs that adjusts the extent to which the mandible (lower jaw) is advanced in response to respiratory signals indicating labored breathing during sleep, and to changes in sleeping position known to affect individual patient's airway patency...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267144/rapid-emergence-of-climate-change-in-environmental-drivers-of-marine-ecosystems
#9
Stephanie A Henson, Claudie Beaulieu, Tatiana Ilyina, Jasmin G John, Matthew Long, Roland Séférian, Jerry Tjiputra, Jorge L Sarmiento
Climate change is expected to modify ecological responses in the ocean, with the potential for important effects on the ecosystem services provided to humankind. Here we address the question of how rapidly multiple drivers of marine ecosystem change develop in the future ocean. By analysing an ensemble of models we find that, within the next 15 years, the climate change-driven trends in multiple ecosystem drivers emerge from the background of natural variability in 55% of the ocean and propagate rapidly to encompass 86% of the ocean by 2050 under a 'business-as-usual' scenario...
March 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/28256271/impact-of-locally-advanced-or-metastatic-prostate-cancer-on-the-quality-of-life
#10
I López-Calderero, L López-Fando, E Ríos-González, P Maisonobe, E Hernández-Yuste, M Sarmiento-Jordán
OBJECTIVE: The aim of this study was to assess the health-related quality of life of patients with prostate cancer in advanced phases to obtain additional information on the patients' health. The growing interest in understanding the patient's perspective and the scarcity of prospective studies of this population motivated this research study. MATERIAL AND METHODS: We present an observational study performed on 131 urology consultations, with a sample of 601 patients with locally advanced or metastatic prostate cancer, assessed during 2 visits: baseline and at 12 months...
February 27, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28243925/utility-of-home-sleep-apnea-testing-in-high-risk-veterans
#11
Alyssa Cairns, Kathleen Sarmiento, Richard Bogan
PURPOSE: Many Veterans Affairs Medical Centers (VAMCs) have implemented home sleep apnea testing (HSAT) in lieu of traditional in-lab testing to establish a timely and cost-sensitive diagnosis of obstructive sleep apnea (OSA). However, concern remains for the sensitivity and specificity of said technology in this population as many veterans are at increased risk for many of the comorbid conditions that can limit the accuracy of HSAT results. Hence, the purpose of this study is to evaluate rate of incongruent outcomes (e...
February 27, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28227462/auto-adjusting-mandibular-repositioning-device-for-in-home-use
#12
R Brugarolas, J M Valero-Sarmiento, A Bozkurt, G K Essick, R Brugarolas, J M Valero-Sarmiento, A Bozkurt, G K Essick, J M Valero-Sarmiento, G K Essick, R Brugarolas, A Bozkurt
Obstructive Sleep Apnea (OSA) is a form of respiratory dysfunction that affects 20% of adults in the world. Among the first-line treatments that are used to mitigate the effects of OSA are continuous positive airway pressure (CPAP) and mandibular repositioning devices (MRD). Although CPAP provides a more efficacious therapy than MRDs, recent studies suggest that both are comparable in overall effectiveness due to greater patient preference and adherence to MRD therapy. In this paper, we present the Auto-Positioner, a novel add-on for MRDs that adjusts the extent to which the mandible (lower jaw) is advanced in response to respiratory signals indicating labored breathing during sleep, and to changes in sleeping position known to affect individual patient's airway patency...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225766/marine-actinobacteria-as-a-source-of-compounds-for-phytopathogen-control-an-integrative-metabolic-profiling-bioactivity-and-taxonomical-approach
#13
Luz A Betancur, Sandra J Naranjo-Gaybor, Diana M Vinchira-Villarraga, Nubia C Moreno-Sarmiento, Luis A Maldonado, Zulma R Suarez-Moreno, Alejandro Acosta-González, Gillermo F Padilla-Gonzalez, Mónica Puyana, Leonardo Castellanos, Freddy A Ramos
Marine bacteria are considered as promising sources for the discovery of novel biologically active compounds. In this study, samples of sediment, invertebrate and algae were collected from the Providencia and Santa Catalina coral reef (Colombian Caribbean Sea) with the aim of isolating Actinobateria-like strain able to produce antimicrobial and quorum quenching compounds against pathogens. Several approaches were used to select actinobacterial isolates, obtaining 203 strains from all samples. According to their 16S rRNA gene sequencing, a total of 24 strains was classified within Actinobacteria represented by three genera: Streptomyces, Micromonospora, and Gordonia...
2017: PloS One
https://www.readbyqxmd.com/read/28198362/covalent-assembly-of-nanoparticles-as-a-peptidase-degradable-platform-for-molecular-mri
#14
Francisco Perez-Balderas, Sander I van Kasteren, Alaa A A Aljabali, Kim Wals, Sébastien Serres, Andrew Jefferson, Manuel Sarmiento Soto, Alexandre A Khrapitchev, James R Larkin, Claire Bristow, Seung Seo Lee, Guillaume Bort, Filippo De Simone, Sandra J Campbell, Robin P Choudhury, Daniel C Anthony, Nicola R Sibson, Benjamin G Davis
Ligand-conjugated microparticles of iron oxide (MPIO) have the potential to provide high sensitivity contrast for molecular magnetic resonance imaging (MRI). However, the accumulation and persistence of non-biodegradable micron-sized particles in liver and spleen precludes their clinical use and limits the translational potential of MPIO-based contrast agents. Here we show that ligand-targeted MPIO derived from multiple iron oxide nanoparticles may be coupled covalently through peptide linkers that are designed to be cleaved by intracellular macrophage proteases...
February 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28196162/the-use-of-recombinant-human-platelet-derived-growth-factor-for-maxillary-sinus-augmentation
#15
Atsushi Kubota, Hector Sarmiento, Mohammed Saad Alqahtani, Arturo Llobell, Joseph P Fiorellini
The maxillary sinus augmentation procedure has become a predictable treatment to regenerate bone for implant placement. The purpose of this study was to evaluate the effect of recombinant human platelet-derived growth factor BB (rhPDGF-BB) combined with a deproteinized cancellous bovine bone graft for sinus augmentation. The lateral window approach was used for maxillary sinuses with minimal residual bone. After a healing period of 4 months, dental implants were placed and then restored following a 2-month osseointegration period...
March 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28185666/-effects-of-a-recreational-general-physical-activity-program-with-short-term-and-moderate-intensity-of-blood-pressure-and-other-cardiovascular-risk-factors-in-hypertensive-patients-over-50-years-old
#16
Ana Torija Archilla, Javier Pérez González, Álvaro Sarmiento Ramírez, Enrique Fernández Sánchez, Josué Rubén González Ruiz, Rafael Guisado Barrilao
OBJECTIVES: To evaluate the effects of a recreational general physical activity program with moderate intensity and short duration on blood pressure and other cardiovascular risk factors (BMI, cholesterol, Rest Heart Rate, HDL, LDL, Triglycerides) in hypertensive patients older than 50years. DESIGN: Non-randomised pre-post design, quasi-experimental study. LOCATION: Íllora, Granada, Spain. PARTICIPANTS: A total of 60 subjects aged 50-75years taking part in the Health Hypertensive Program in the Medical Centre were selected...
February 6, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28169531/branimycins-b-and-c-antibiotics-produced-by-the-abyssal-actinobacterium-pseudonocardia-carboxydivorans-m-227
#17
Alfredo F Braña, Aida Sarmiento-Vizcaíno, Ignacio Pérez-Victoria, Luis Otero, Jonathan Fernández, Juan José Palacios, Jesús Martín, Mercedes de la Cruz, Caridad Díaz, Francisca Vicente, Fernando Reyes, Luis A García, Gloria Blanco
Two new antibiotics, branimycins B (2) and C (3), were produced by fermentation of the abyssal actinobacterium Pseudonocardia carboxydivorans M-227, isolated from deep seawater of the Avilés submarine Canyon. Their structures were elucidated by HRMS and NMR analyses. These compounds exhibit antibacterial activities against a panel of Gram-positive bacteria, including Corynebacterium urealyticum, Clostridium perfringens, and Micrococcus luteus, and against the Gram-negative bacterium Neisseria meningitidis...
February 24, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28167034/stwrky8-transcription-factor-regulates-benzylisoquinoline-alkaloid-pathway-in-potato-conferring-resistance-to-late-blight
#18
Kalenahalli N Yogendra, Dhananjay Dhokane, Ajjamada C Kushalappa, Felipe Sarmiento, Ernesto Rodriguez, Teresa Mosquera
The resistance to late blight is either qualitative or quantitative in nature. Quantitative resistance is durable, but challenging due to polygenic inheritance. In the present study, the diploid potato genotypes resistant and susceptible to late blight, were profiled for metabolites. Tissue specific metabolite analysis of benzylisoquinoline alkaloids (BIAs) in response to pathogen infection revealed increased accumulation of morphinone, codeine-6-glucuronide and morphine-3-glucuronides. These BIAs are antimicrobial compounds and possibly involved in cell wall reinforcement, especially through cross-linking cell wall pectins...
March 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28161847/study-of-gastrointestinal-parasites-in-water-buffalo-bubalus-bubalis-reared-under-mexican-humid-tropical-conditions
#19
Nadia Florencia Ojeda-Robertos, Oswaldo Margarito Torres-Chablé, Jorge Alonso Peralta-Torres, Carlos Luna-Palomera, Aguilar Aguilar-Cabrales, Alfonso Juventino Chay-Canul, Roberto González-Garduño, Carlos Machain-Williams, Ramón Cámara-Sarmiento
The objective was to determine the frequency of gastrointestinal parasites (GP) genera affecting water buffalo (Bubalus bubalis) reared under humid tropical conditions of Mexico. Three hundred eighty-three Munrah breed water buffalo were included, 251 adult females and 132 calves. Feces were directly collected form the rectum of the animals and processed by the McMaster technique. Coprocultures were made to identify the genera of the nematodes. The frequency of GP in B. bubalis was 42%, independently of their age, 60% of calves resulted parasitized...
March 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28159238/in-vitro-effects-of-tamoxifen-on-equine-neutrophils
#20
C Borlone, N Morales, C Henriquez, H Folch, C Olave, J Sarmiento, B Uberti, G Moran
Neutrophils participate in innate immunity as the first line of host defense against microorganisms. However, exacerbated neutrophil activity can be harmful to surrounding tissues; this is important in a range of diseases, including allergic asthma and chronic obstructive pulmonary disease in humans, and equine asthma (also known as recurrent airway obstruction (RAO). Tamoxifen (TX) is a non-steroidal estrogen receptor modulator with effects on cell growth and survival. Previous preliminary studies showed that TX treatment in horses with induced acute pulmonary inflammation promoted early apoptosis of blood and BALF neutrophils, reduction of BALF neutrophils, and improvement in animals' clinical status...
February 2017: Research in Veterinary Science
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