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JOURNAL ARTICLE
Alberto Rivera-Ramos, Luis Cruz Hernández, Rocío Talaverón, María Teresa Sánchez Montero, Juan García-Revilla, Marta Mulero-Acevedo, Tomas Deierborg, José Luis Venero, Manuel Sarmiento Soto
Galectin-3 (Gal-3) is a multifunctional protein that plays a pivotal role in the initiation and progression of various central nervous system diseases, including cancer. Although the involvement of Gal-3 in tumour progression, resistance to treatment and immunosuppression has long been studied in different cancer types, mainly outside the central nervous system, its elevated expression in myeloid and glial cells underscores its profound impact on the brain's immune response. In this context, microglia and infiltrating macrophages, the predominant non-cancerous cells within the tumour microenvironment, play critical roles in establishing an immunosuppressive milieu in diverse brain tumours...
April 16, 2024: Cancer Letters
#2
JOURNAL ARTICLE
S A Sarmiento, E Moncada-Villa, J R Mejía-Salazar
In this Letter, we introduce a concept to produce high-resolution, highly integrable biosensing devices. Our idea exploits the highly absorbing modes in multilayered metamaterials to maximize the transverse magneto-optical Kerr effect (TMOKE). Results are discussed in the context of dielectric uniaxial ( ε eff,∥ ε eff,⊥ >0) and hyperbolic metamaterial ( ε eff,∥ ε eff,⊥ <0) regimes. For applications in gas sensing, we obtained sensitivities of S = 46...
April 15, 2024: Optics Letters
#3
REVIEW
Vinícius Caldeira Quintão, Mario Concha, Lina Andrea Sarmiento Argüello, Silvana Cavallieri, Luis I Cortinez, Gabriel Soares de Sousa, Marcella Marino Malavazzi Clemente, Ricardo Vieira Carlos, Juan Manuel Rodríguez, Karla Gutiérrez, Denis H Jablonka, Annery G García-Marcinkiewicz
BACKGROUND: Latin America comprises an extensive and diverse territory composed of 33 countries in the Caribbean, Central, and South America where Romance languages-languages derived from Latin are predominantly spoken. Economic disparities exist, with inequitable access to pediatric surgical care. The Latin American Surgical Outcomes Study in Pediatrics (LASOS-Peds), a multi-national collaboration, will determine safety of pediatric anesthesia and perioperative care. OBJECTIVE: Below, we provide a descriptive initiative to share how pediatric anesthesia in Brazil, Chile, and Mexico operate...
April 15, 2024: Paediatric Anaesthesia
#4
JOURNAL ARTICLE
Rocío Pastor, Juliana Puyssegur, M Paula de la Guardia, Lindybeth Sarmiento Varón, Gladys Beccaglia, Nicolás Spada, Andrea Paes de Lima, M Soledad Collado, Andrés Blanco, Isabel Aspe Scetti, M Elena Arabolaza, Bibiana Paoli, Fernando Chirdo, Eloísa Arana
BACKGROUND: The tonsils operate as a protection ring of mucosa at the gates of the upper aero-digestive tract. They show similarities with lymph nodes and participate as inductive organs of systemic and mucosal immunity. Based on the reduction of their size since puberty, they are thought to experience involution in adulthood. In this context, we have used tonsillar mononuclear cells (TMC) isolated from patients at different stages of life, to study the effect of ageing and the concomitant persistent inflammation on these immune cells...
April 12, 2024: Immunity & Ageing: I & A
#5
JOURNAL ARTICLE
Lisa Thompson, Thomas Patrianakos, James Garcia, Arshia Wadhwa, Ellen Yang, Catherine Thomas, Robin Schneider, Hudson Stern, Camille Palma, Kyle Hill, Viviana Barquet, Susan Anderson-Nelson, Kenneth McMahon, Umangi Patel, Quraish Ghadiali, Dagmara Danek, Brian Larsen, Anthony Wong, Sherif Dawood, Maxine Ludington, George Zhang, Roya Garakani, Surendar Dwarakanathan, Athina Simotas, Kajal Sangal, Paul Phelps, Taylor Ashourian, Dana Darwish, Sonya Bamba, Michael Zein, Jeffrey Nichols, Josiah To, Angelo Sarmiento, Shweta Chaudhary, Brett Breshears, Josh Nelson, Susan Anderson-Nelson, Michael Giovingo
No abstract text is available yet for this article.
April 11, 2024: Disease-a-month: DM
#6
JOURNAL ARTICLE
Paulo Tigreros-Benavides, Luis Garzón-Rodríguez, Gysseth Herrera-Villarraga, Jesús Ochoa-Mogollón, Camila Sarmiento-Sánchez, Luz Helena Rodríguez-Vargas, Gladys Rozo-Torres, Paula Guayán-Ruíz, Adolfo Sanjuan-Muñoz, Andrés Franco-Herrera
Pollution generated by plastic waste has brought an environmental problem characterized by the omnipresence of smaller pieces of this material known as microplastics (MP). This issue was addresses by collecting samples with 250 μm pore size nets in two marine-coastal sectors of Southwestern Caribbean Sea during two contrasting seasons. Higher concentrations were found in rainy season than in dry season, reaching respectively 1.72 MP/m3 and 0.22 MP/m3 . Within each sector, there were differences caused firstly by localities of higher concentrations of semi-closed water bodies localities during rainy season (Ciénaga Grande de Santa Marta and La Caimanera marsh), and secondly by lower concentrations of localities with less influenced of flow rates during dry season (Salamanca and Isla Fuerte)...
April 9, 2024: Journal of Environmental Management
#7
JOURNAL ARTICLE
Kathleen F Sarmiento, Alexander Gomez, Charles W Atwood
No abstract text is available yet for this article.
April 10, 2024: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
#8
JOURNAL ARTICLE
Hiwot Y Zewdie, Olga Lucia Sarmiento, Jose David Pinzón, Maria A Wilches-Mogollon, Pablo Andres Arbelaez, Laura Baldovino-Chiquillo, Dario Hidalgo, Luis Angel Guzman, Stephen J Mooney, Quynh C Nguyen, Tolga Tasdizen, D Alex Quistberg
Nine in 10 road traffic deaths occur in low- and middle-income countries (LMICs). Despite this disproportionate burden, few studies have examined built environment correlates of road traffic injury in these settings, including in Latin America. We examined road traffic collisions in Bogotá, Colombia, occurring between 2015 and 2019, and assessed the association between neighborhood-level built environment features and pedestrian injury and death. We used descriptive statistics to characterize all police-reported road traffic collisions that occurred in Bogotá between 2015 and 2019...
April 8, 2024: Journal of Urban Health
#9
JOURNAL ARTICLE
Philipp K Zuber, Nelly Said, Tarek Hilal, Bing Wang, Bernhard Loll, Jorge González-Higueras, César A Ramírez-Sarmiento, Georgiy A Belogurov, Irina Artsimovitch, Markus C Wahl, Stefan H Knauer
RfaH, a paralog of the universally conserved NusG, binds to RNA polymerases (RNAP) and ribosomes to activate expression of virulence genes. In free, autoinhibited RfaH, an α-helical KOW domain sequesters the RNAP-binding site. Upon recruitment to RNAP paused at an ops site, KOW is released and refolds into a β-barrel, which binds the ribosome. Here, we report structures of ops-paused transcription elongation complexes alone and bound to the autoinhibited and activated RfaH, which reveal swiveled, pre-translocated pause states stabilized by an ops hairpin in the non-template DNA...
April 8, 2024: Nature Communications
#10
JOURNAL ARTICLE
Narendar Kolimi, Jake Ballard, Thomas Peulen, Rajen Goutam, Francis X Duffy, César A Ramírez-Sarmiento, Jorge Babul, Exequiel Medina, Hugo Sanabria
Transcription factors (TFs) regulate gene expression by binding to specific DNA sequences and gating access to genes. Even when the binding of TFs and their cofactors to DNA is reversible, indicating a reversible control of gene expression, there is little knowledge about the molecular effect DNA has on TFs. Using single-molecule multiparameter fluorescence spectroscopy, molecular dynamics simulations, and biochemical assays, we find that the monomeric form of the forkhead (FKH) domain of the human FoxP1 behaves as a disordered protein and increases its folded population when it dimerizes...
March 20, 2024: Cell reports. Physical science
#11
JOURNAL ARTICLE
Veterans Health Administration response to 2021 recall of Philips Respironics devices: A case study.
Jeffrey K Belkora, Barry Fields, Q Afifa Shamim-Uzzaman, Donna Stratford, David Alfandre, Scott Hollingshaus, Edward Yackel, Cynthia Geppert, Penny Nechanicky, Ardene Nichols, Katherine Williams, Jill Reichert, Mary A Whooley, Joe Francis, Kathleen F Sarmiento
This case study describes, for the time frame of June 2021 through August 2022, the U.S. Veterans Health Administration (VHA) organizational response to a manufacturer's recall of positive airway pressure devices used in the treatment of sleep disordered breathing. VHA estimated it could take over a year for Veterans to receive replacement devices. Veterans awaiting a replacement faced a dilemma. They could continue using the recalled devices and bear the product safety risks that led to the recall, or they could stop using them and bear the risks of untreated sleep disordered breathing...
April 12, 2023: Front Sleep
#12
REVIEW
Doris Sarmiento-Altamirano, Fernanda Ormaza, María Rosa Arroyo, Catherine Cabrera-Ordoñez, Rafael Valdivieso, Megan Docksey, Salomone Di Saverio
BACKGROUND: Simulation is an innovative tool for developing complex skills required for surgical training. The objective of this study was to determine the advancement of laparoscopic and robotic skills through simulation in participants with limited or no previous experience. METHODS: This is a systematic review and meta-analysis of randomized controlled trials (RCTs) in keeping with the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines...
April 2024: Journal of Gastrointestinal Surgery
#13
JOURNAL ARTICLE
Ainhoa Sarmiento-García, Begoña Rubio, Beatriz Martinez, Juan-José García, Ceferina Vieira
This study aims to evaluate the effect of different dietary fat sources on the quality of a Spanish-cooked meat product Lomo de Sajonia (LSA) and its shelf-life. Forty loins were selected from Iberian pigs fed four dietary treatments containing pork fat (G-1), Greedy-Grass Olive® (GGO) (enriched oleic-acid oil) (G-2), G-2 and high oleic sunflower (G-3), and G-3 plus a mixture of commercial organic acids (Bioll®) (G-4). Loins were manufactured to obtain LSA, and the quality and sensorial attributes were assessed...
2024: Animal Science Journal
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JOURNAL ARTICLE
Jasper A J Smits, Michael J Zvolensky, Marshall K Cheney, David Rosenfield, Richard Brown, Stacy Stevens Manser, Michael W Otto, Slaton Z Freeman, Marla Sarmiento, Sydney Thureen
Anxiety sensitivity (AS), reflecting the fear of bodily sensations, is a transdiagnostic vulnerability factor that underpins both affective psychopathology and smoking. Phase II research supports the efficacy of a 15-week community-based intervention (STEP) that combines high-intensity exercise offered by the YMCA with standard smoking cessation treatment (tobacco quitline and nicotine replacement therapy) for sedentary smokers with elevated AS. This Phase III study aims to enroll 360 adults to evaluate whether STEP efficacy for achieving smoking abstinence generalizes to Black and Hispanic smokers with elevated AS...
April 3, 2024: Contemporary Clinical Trials
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JOURNAL ARTICLE
Viviana Sarmiento, Kristin Hamre, Aleksander Arnø, Joshua Dagogo, Elisabeth Ødegård, Odd Elvebø, Pedro Araujo
The perception of polyphenols as a safe, healthy, and sustainable solution for replacing synthetic antioxidants has been an important factor for their rapid growing in the global food market. Therefore, it is essential to use reliable methods for their quantification in commercial products intended for animal or human consumption. The purpose of this study is to evaluate the performance of some solvents used for the extraction of selected polyphenols, explore their stability under different experimental conditions, and validate a liquid chromatography tandem mass-spectrometry method for their quantification in commercial fish feed ingredients by using the standard addition method...
March 28, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
#16
JOURNAL ARTICLE
Ignacio J Keller Sarmiento, Bernabe I Bustos, Joanna Blackburn, Nicholas E F Hac, Maura Ruzhnikov, Matthea Monroe, Rebecca J Levy, Lisa Kinsley, Megan Li, Vincenzo Silani, Steven J Lubbe, Dimitri Krainc, Niccolò E Mencacci
BACKGROUND: FRMD5 variants were recently identified in patients with developmental delay, ataxia, and eye movement abnormalities. OBJECTIVES: We describe 2 patients presenting with childhood-onset ataxia, nystagmus, and seizures carrying pathogenic de novo FRMD5 variants. Weighted gene co-expression network analysis (WGCNA) was performed to gain insights into the function of FRMD5 in the brain. METHODS: Trio-based whole-exome sequencing was performed in both patients, and CoExp web tool was used to conduct WGCNA...
April 4, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#17
JOURNAL ARTICLE
Beatriz León-Salas, Amaia Bilbao-González, Ana María de Pascual Y Medina, Magdalena Esteva, Ana Toledo-Chávarri, Claudio Fuentes-Sánchez, Uriel Bohn-Sarmiento, Pilar Padrón-Peña, Sonia González-Sánchez, Rafael Valcárcel-López, María Del Mar Trujillo-Martín
PURPOSE: The aim of this study was to translate, culturally adapt, and evaluate the psychometric properties of the Spanish Long-Term Quality of Life (LTQL) questionnaire. METHODS: The LTQL was initially translated into Spanish and cross-culturally adapted based on established guidelines. The Spanish LTQL was administered to patients with breast cancer who had completed their initial treatment 5 years earlier, along with other self-report measures: Quality of Life in Adult Cancer Survivors (QLACS), Hospital Anxiety and Depression Scale (HADS) and EORT-QLQ-BR23...
2024: Frontiers in Oncology
#18
JOURNAL ARTICLE
Lauren Falvo, Anna Bona, Melanie Heniff, Dylan Cooper, Malia Moore, Devin Doos, Elisa Sarmiento, Cherri Hobgood, Rami Ahmed
INTRODUCTION: Medical errors are an unfortunate certainty with emotional and psychological consequences for patients and health care providers. No standardized medical curriculum on how to disclose medical errors to patients or peers exists. The novel HEEAL (honesty/empathy/education/apology-awareness/lessen chance for future errors) curriculum addresses this gap in medical education through a multimodality workshop. METHODS: This 6-hour, two-part curriculum incorporated didactic and standardized patient (SP) simulation education with rapid cycle deliberate practice (RCDP)...
2024: MedEdPORTAL Publications
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JOURNAL ARTICLE
Virginia McKay, Yichen Chen, Kim Prewitt, Sara Malone, Maria Puerto-Torres, Carlos Acuña-Aguirre, Yvania Alfonso-Carreras, Shilel Y Alvarez-Arellano, Leticia A Andrade-Sarmiento, Daniela Arce-Cabrera, Deiby Argüello-Vargas, Mariuxy D C Barragán-García, Rosario Batista-Del-Cid, Erika E Blasco-Arriaga, Maria D C Cach-Castaneda, Gloria I Ceballo-Batista, Mayra Chávez-Rios, Maria E Costa, Maria E Cuencio-Rodriguez, Rosdali Diaz-Coronado, Ever A Fing-Soto, Teresa D J García-Sarmiento, Wendy C Gómez-García, Cinthia J Hernández-González, Yajaira V Jimenez-Antolinez, Maria S Juarez-Tobias, Esmeralda M León-López, Norma A Lopez-Facundo, Ruth A Martínez Soria, Scheybi T Miralda-Méndez, Erika Montalvo, Carlos M Pérez-Alvarado, Clara K Perez-Fermin, Monica L Quijano-Lievano, Beatriz Salas-Mendoza, Edwin E Sanchez-Fuentes, Marcia X Serrano-Landivar, Veronica Soto-Chavez, Isidoro Tejocote-Romero, Sergio Valle, Elizabeth A Vasquez-Roman, Juliana Texeira Costa, Adolfo Cardenas-Aguirre, Meenakshi Devidas, Douglas A Luke, Asya Agulnik
Clinical capacity for sustainability, or the clinical resources needed to sustain an evidence-based practice, represent proximal determinants that contribute to intervention sustainment. We examine the relationship between clinical capacity for sustainability and sustainment of PEWS, an evidence-based intervention to improve outcomes for pediatric oncology patients in resource-variable hospitals. We conducted a cross-sectional survey among Latin American pediatric oncology centers participating in Proyecto Escala de Valoración de Alerta Temprana (EVAT), an improvement collaborative to implement Pediatric Early Warning Systems (PEWS)...
March 2024: Glob Implement Res Appl
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JOURNAL ARTICLE
Cristian Rojas, Nicole Sarmiento, Emilia Ayora, Reinaldo Pis Diez
BACKGROUND: Veterinary antibiotics are chemical compounds used to kill or inhibit the growth of pathogenic bacteria associated with animal diseases. These molecules can be defined by the retention times (tR ) in liquid chromatography-mass spectrometry (LC-MS). One strategy to predict the tR of new veterinary antibiotics is the development of predictive quantitative structure-property relationship (QSPRs), which were used in this study. RESULTS: A database of 122 antibiotics was selected in which the tR was measured using a Hypersil Gold column...
March 29, 2024: Journal of the Science of Food and Agriculture
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