Xuehui Long, Sulin Zhang, Yuliang Wang, Jingjing Chen, Yanlai Lu, Hui Hou, Bichun Lin, Xutong Li, Chang Shen, Ruirui Yang, Huamin Zhu, Rongrong Cui, Duanhua Cao, Geng Chen, Dan Wang, Yun Chen, Sulan Zhai, Zhiqin Zeng, Shusheng Wu, Mengting Lou, Junhong Chen, Jian Zou, Mingyue Zheng, Jun Qin, Xiaoming Wang
Regulatory T (Treg ) cells are critical for immune tolerance but also form a barrier to antitumor immunity. As therapeutic strategies involving Treg cell depletion are limited by concurrent autoimmune disorders, identification of intratumoral Treg cell-specific regulatory mechanisms is needed for selective targeting. Epigenetic modulators can be targeted with small compounds, but intratumoral Treg cell-specific epigenetic regulators have been unexplored. Here, we show that JMJD1C, a histone demethylase upregulated by cytokines in the tumor microenvironment, is essential for tumor Treg cell fitness but dispensable for systemic immune homeostasis...
March 2024: Nature Immunology