Read by QxMD icon Read

infiltrative pushing margin

M F Rodrigues, P T Truong, E C McKevitt, L M Weir, M A Knowling, E S Wai
PURPOSE: Phyllodes tumors of the breast are uncommon fibroepithelial lesions for which optimal management remains unclear. This retrospective population-based study reports treatment and outcomes for patients with phyllodes tumors and evaluates characteristics that influence outcome. MATERIALS AND METHODS: Data were analysed on 183 patients with newly diagnosed phyllodes tumors from 1999 to 2014. Five-year Kaplan-Meier local recurrence and survival were compared between cohorts with benign (n=83), borderline (n=50) and malignant phyllodes tumor (n=49) histology...
April 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Padam Parmar, Nisha Marwah, Sanjeev Parshad, Taruna Yadav, Ashima Batra, Rajeev Sen
Various studies have demonstrated that the lymphatic system is the additional route for solid tumor metastasis. Lymph nodes metastasis in Head and neck squamous cell carcinoma (HNSCC) is a major prognostic indicator for disease progression and a guide for therapeutic strategies. We conducted a study to compare intratumoral (IT) and peritumoral (PT) lymphatic vessel density (LVD) in HNSCC using lymphatic marker D2-40 and its correlation with lymph node metastasis, histological grading and other clinicopathological parameters...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
Ho-Hsian Yen, Hong-Jen Chiou, Yi-Hong Chou, Chih-Hsueh Chen, Wan-Yuo Guo
We evaluated nodular fasciitis (NF) in 19 patients, focusing on the correlation between its sonographic and histopathologic features. Sonograms were retrospectively reviewed, and the location, shape, margin, echogenicity, echogenic rim, peripheral hyper-echoic nodules, posterior enhancement and vascularity of the lesions were recorded. In the histopathologic analysis, three patterns-infiltrating, pushing border and well circumscribed-were identified, and culture-like tissue centers were classified according to the distribution of focal keloid-like collagen bundles: uneven or even...
April 2017: Ultrasound in Medicine & Biology
Ahmed Farag Ahmed Farag, Mohamed Yehia Elbarmelgi, Hamdy A Azim, Ahmed Abdelaziz Abozeid, Abdrabou N Mashhour
AIM: TNM staging and histological grading of rectal cancer has undergone no or minimal changes during the past 20 years despite their major impact on planning, reporting and outcome of the disease. The addition of category 'F' to the 'TNM' staging of colorectal cancer, which becomes TNMF will accommodate the expanding list of risk factors that may affect the management and thus avoid squeezing them into the TNM categories. METHODS: Reporting of the following risk factors was traced in 730 (664 retrospective and 66 prospective) cases of colorectal cancer: age, Tumor location, preoperative CEA, intraoperative tumor perforation and blood transfusion, quality of TME, tumor grade, non nodal T...
March 2016: International Journal of Surgery
Tim Hanke, Nathaniel Melling, Ronald Simon, Guido Sauter, Carsten Bokemeyer, Patrick Lebok, Luigi M Terracciano, Jakob R Izbicki, Andreas H Marx
Immunologic profiling of colorectal cancer (CRC) may help to predict the tumors metastatic potential and patients with an aggressive tumor, although not yet metastasized at time of surgery might benefit from adjuvant therapy. In this study we evaluated the prognostic significance of FOXP3(+) T regulatory cells (Tregs), CD3(+) and CD8(+) lymphocyte densities and conventional histopathologic features in nodal negative (n = 820, UICC stage II) CRC. Immunohistochemical studies showed that high expression of FOXP3(+) Tregs is significantly linked to a better clinical outcome (P = 0...
2015: International Journal of Clinical and Experimental Pathology
Séverine Guiu, Céline Charon-Barra, Déwi Vernerey, Pierre Fumoleau, Mario Campone, Marc Spielmann, Henri Roché, Christel Mesleard, Laurent Arnould, Jérôme Lemonnier, Magali Lacroix-Triki
AIM: Microarray studies identified a subgroup of molecular apocrine tumors (estrogen receptor [ER] negative/androgen receptor [AR] positive) that express luminal genes including FOXA1. FOXA1 may direct AR to sites normally occupied by ER in luminal tumors, inducing an estrogen-like gene program that stimulated proliferation. MATERIALS & METHODS: Expression of AR and FOXA1 was evaluated by immunohistochemistry in 592 patients with nonmetastatic triple-negative breast cancer (TNBC)...
2015: Future Oncology
Małgorzata Kołos, Anna Wasążnik-Jędras, Anna Nasierowska-Guttmejer
Colorectal cancer (CRC) is the most common type of gastrointestinal cancer and has three major pathways of carcinogenesis. About 80% of genomic instability concerns chromosomal instability (CIN); the rest is connected with either microsatellite instability (MSI) or CpG island methylation. Some MSI-related cancers are associated with Lynch syndrome, whereas others are caused by sporadic, acquired hypermethylation of the promoter of the MLH1 gene. These tumours have distinctive clinical and histopathological features...
June 2015: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Eva Karamitopoulou, Inti Zlobec, Viktor Hendrik Koelzer, Rupert Langer, Heather Dawson, Alessandro Lugli
AIMS: Information on tumour border configuration (TBC) in colorectal cancer (CRC) is currently not included in most pathology reports, owing to lack of reproducibility and/or established evaluation systems. The aim of this study was to investigate whether an alternative scoring system based on the percentage of the infiltrating component may represent a reliable method for assessing TBC. METHODS AND RESULTS: Two hundred and fifteen CRCs with complete clinicopathological data were evaluated by two independent observers, both 'traditionally' by assigning the tumours into pushing/infiltrating/mixed categories, and alternatively by scoring the percentage of infiltrating margin...
October 2015: Histopathology
Luis Ricardo Ramírez-González, Karla Lisseth Leonher-Ruezga, Francisco Javier Plascencia-Posadas, José Alfredo Jiménez-Gómez, José López-Zamudio, Clotilde Fuentes-Orozco
BACKGROUND: Meckel's diverticulum is the most common congenital anomaly in the small intestine, which results from incomplete obliteration omphalomesenteric duct, usually the diagnosis is incidental, rarely reaching with bleeding, obstruction, diverticulitis or in rare cases a neoplasm. Clinic case: 67 year old woman that started her condition with urinary symptoms (dysuria, frequency, bladder tenesmus and pushing), within the study protocol a cystogram was performed and demonstrated a defect in the bladder dome edges with compression effect, the computed tomography reported a bladder infiltrating hypodense lesion, which is decided to resect finding Meckel's diverticulum with a tumor that infiltrates the bladder dome, the histopathological confirmed the diagnosis shown free edges but insufficient, which need a reintervention to increase margins; all the extension studies shown without tumor activity...
March 2014: Cirugia y Cirujanos
Nobuaki Tanaka, Taku Yamashita, Sohei Yamamoto, Takeshi Matsunobu, Hitoshi Tsuda, Kazufumi Honda, Tesshi Yamada, Seiichi Tamai, Akihiro Shiotani
AIM: To assess the clinicopathological significance of the histological growth pattern (HGP) and α-actinin-4 (ACTN4) expression in thyroid cancer. PATIENTS AND METHODS: We classified 83 thyroid cancer cases into infiltrative margin (IM) and pushing margin (PM) groups according to peripheral tumor margin contour and immunohistochemically determined ACTN4 expression. Correlations between clinical stage and clinicopathological characteristics were analyzed. RESULTS: IM and high ACTN4 expression were observed in 39% and 49% of cancer cases, respectively...
June 2014: Anticancer Research
Viktor H Koelzer, Alessandro Lugli
Histomorphological features of colorectal cancers (CRC) represent valuable prognostic indicators for clinical decision making. The invasive margin is a central feature for prognostication shaped by the complex processes governing tumor-host interaction. Assessment of the tumor border can be performed on standard paraffin sections and shows promise for integration into the diagnostic routine of gastrointestinal pathology. In aggressive CRC, an extensive dissection of host tissue is seen with loss of a clear tumor-host interface...
2014: Frontiers in Oncology
Bilal O Al-Jiffry, Yasir Alnemary, Samah H Khayat, Moutaz Haiba, Mohammed Hatem
BACKGROUND: Pancreatic paragangliomas are rare tumors, with only 16 reported cases to date. One of these cases demonstrates metastasis to lymph node, while another case was functional, however, none of these cases showed malignant and large, pancreatic paraganglioma with marked invasion. Also another unique feature was the age of our patient compared to the average reported ages in published literature (42-85 years). CASE PRESENTATION: A 19-year-old woman presented with a one-year history of intermittent abdominal pain...
2013: BMC Cancer
Rafael S Pinheiro, Paulo Herman, Renato M Lupinacci, Quirino Lai, Evandro S Mello, Fabricio F Coelho, Marcos V Perini, Vincenzo Pugliese, Wellington Andraus, Ivan Cecconello, Luiz Carneiro D'Albuquerque
BACKGROUND: Surgical resection is the gold standard therapy for the treatment of colorectal liver metastases (CRM). The aim of this study was to investigate the impact of tumor growth patterns on disease recurrence. METHODS: We enrolled 91 patients who underwent CRM resection. Pathological specimens were prospectively evaluated, with particular attention given to tumor growth patterns (infiltrative vs pushing). RESULTS: Tumor recurrence was observed in 65 patients (71...
April 2014: American Journal of Surgery
Li-ping Liu, Jun Bai, Ya Wei, Xiao-dong Qi, Ting-chen Si, Wei Li, Hui Pan
OBJECTIVE: To investigate the clinicopathologic features and immunohistochemical of the basal-like subtype of invasive breast carcinoma (BLBC), and to discuss the diagnosis standard. METHODS: Immunohistochemistry was performed in 448 cases of breast carcinoma and these cases were categorized into luminal A, luminal B, null subtypes, HER2-overexpressing and basal-like and their clinicopathologic features were observed under light microscope with stains of HE and immunohistochemical InVitrogen staining...
February 2013: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Kristin K Alexiusdottir, Petur Snaebjornsson, Laufey Tryggvadottir, Larus Jonasson, Elinborg J Olafsdottir, Einar Stefan Björnsson, Pall Helgi Möller, Jon G Jonasson
Available data correlating symptoms of colon cancer patients with the severity of the disease are very limited. In a population-based setting, we correlated information on symptoms of colon cancer patients with several pathological tumor parameters and survival. Information on all patients diagnosed with colon cancer in Iceland in 1995-2004 for this retrospective, population-based study was obtained from the Icelandic Cancer Registry. Information on symptoms of patients and blood hemoglobin was collected from patients' files...
October 2013: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Jennifer S Kaplan, Stuart J Schnitt, Laura C Collins, Yihong Wang, Judy E Garber, Kelli Montgomery, Robert B West, Karen Krag, Katharina Fetten, Anne Lincoln, Nadine M Tung
Although most breast cancers in BRCA1 mutation carriers are estrogen receptor negative (ER-) with a basal-like phenotype, up to one third are ER positive (ER+). Little is known about the characteristics of this subgroup. To address this, we compared histologic and immunophenotypic features of 60 BRCA1-related ER+ breast cancers with those of 85 BRCA1-related ER- cancers and 174 matched ER+ sporadic cancers. ER+ BRCA1-related cancers were significantly less likely than ER- BRCA1-related cancers to be of pure invasive ductal type (P<0...
October 2012: American Journal of Surgical Pathology
Jae Hyuck Jang, Min-Young Choi, Se Kyung Lee, Sangmin Kim, Jiyoung Kim, Jeonghui Lee, Seung Pil Jung, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim, Eun Yoon Cho, Jeong Eon Lee, Seok Jin Nam, Jung-Hyun Yang
BACKGROUND: Phyllodes tumors (PTs) are rare breast tumors that usually occur in middle-aged women. Here we discuss our recent experiences in the diagnosis, surgical management, and clinical follow-up of this disease. METHODS: We retrospectively reviewed 164 patients with PTs who underwent surgical treatment at the Department of Surgery, Samsung Medical Center, Seoul, Korea, from January 1995 to July 2009. Clinical and histopathological data were analyzed. RESULTS: The median follow-up period was 33...
August 2012: Annals of Surgical Oncology
E Belin, K Ezzedine, S Stanislas, N Lalanne, M Beylot-Barry, A Taieb, B Vergier, T Jouary
BACKGROUND: Primary eccrine porocarcinoma is a rare cutaneous neoplasm and there is no consensus concerning its surgical management. OBJECTIVES: To conduct a retrospective analysis of all the cases of eccrine porocarcinoma seen in our hospital in order to identify prognostic factors. METHODS: Clinical data were retrieved from the patients' files. Each histological sample was reviewed by the pathologist and classified into three eccrine porocarcinoma subtypes: 'infiltrative', 'pushing' and 'pagetoid' eccrine porocarcinoma, according to Robson's criteria...
November 2011: British Journal of Dermatology
W Dolak, M Raderer, J Maresch, L Muellauer, A Puespoek, A Chott, M Haefner
Mucosa-associated lymphoid tissue (MALT) lymphoma is thought to be a multifocal disease with sometimes synchronous involvement of various mucosal structures. In this study we aimed to evaluate the potential involvement of the small bowel in patients suffering from gastric MALT lymphoma by analyzing the results of enteroscopy, a technique that allows easy and safe access to the small bowel with the potential for histological assessment of biopsy samples. We have retrospectively evaluated 347 enteroscopies and found nine patients with gastric MALT lymphoma who had undergone push enteroscopy with serial biopsies during staging...
August 2011: Endoscopy
Chiara Mussi, Piergiuseppe Colombo, Alexia Bertuzzi, Massimiliano Coladonato, Pietro Bagnoli, Simona Secondino, Pierina Navarria, Emanuela Morenghi, Armando Santoro, Vittorio Quagliuolo
BACKGROUND: Complete tumor resection is the mainstay of treatment for retroperitoneal sarcoma (RPS), but the size and quality of surgical margins for radical resection in RPS are unknown. They are believed to be pushing tumors, but recently, aggressive surgical policies leading to multivisceral resection have seemed to suggest better local control compared with simple tumor resection. We analyzed a single-institution series of RPS to provide information useful to surgical decision-making...
August 2011: Annals of Surgical Oncology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"