Thaer Khoury, Marilin Rosa, Anupma Nayak, Rouzan Karabakhtsian, Oluwole Fadare, Zaibo Li, Bradley Turner, Yisheng Fang, Asangi Kumarapeli, Xiaoxian Li, Numbereye Numbere, Tatiana Villatoro, Ji-Gang Wang, Saed Sadeghi, Kristopher Attwood, Anthony George, Rohit Bhargava
Adenoid cystic carcinoma (AdCC) is an uncommon type of invasive breast carcinoma with a favorable prognosis. However, some cases are aggressive. The study aims to define the clinicopathologic predictors of outcome. Clinical, radiological, and pathologic variables were recorded for 76 AdCC cases from 11 institutions. The following histologic characteristics were evaluated by the breast pathologist in each respective institution, including Nottingham grade (NG), percentages of various growth patterns (solid, cribriform, trabecular-tubular), percentage of basaloid component, tumor borders (pushing, infiltrative), perineural invasion, lymphovascular invasion, necrosis, and distance from the closest margin...
February 2023: Modern Pathology