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https://www.readbyqxmd.com/read/28736645/effect-of-helicobacter-pylori-infection-on-outcomes-in-resected-gastric-and-gastroesophageal-junction-cancer
#1
Jennifer M Kolb, Umut Ozbek, Noam Harpaz, Randall F Holcombe, Celina Ang
BACKGROUND: Helicobacter pylori (H pylori) infection is a known risk factor for gastric cancer (GC) and has been linked with gastroesophageal junction (GEJ) cancer. Studies examining the relationship between H. pylori infection, GC characteristics and prognosis are limited and have yielded conflicting results. We report on the clinicopathologic characteristics and oncologic outcomes of gastric and GEJ cancer patients with and without a history of H. pylori treated at our institution. METHODS: We retrospectively reviewed the medical records of patients over the age of 18 years who underwent curative resection for GEJ and GC at Mount Sinai Hospital between 2007 and 2012 who had histopathologic documentation of the presence or absence of H pylori infection...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28735300/caveolin-1-expression-as-a-prognostic-marker-in-triple-negative-breast-cancers-of-asian-women
#2
Joe Yeong, Aye Aye Thike, Murasaki Ikeda, Jeffrey Chun Tatt Lim, Bernett Lee, Seigo Nakamura, Jabed Iqbal, Puay Hoon Tan
BACKGROUND: Triple-negative breast cancers (TNBCs) are defined by their lack of oestrogen receptor, progesterone receptor and epidermal growth factor receptor 2. Although heterogeneous, the majority are aggressive and treatment options are limited. Caveolin acts as tumour suppressor or promoter depending on the cancer type. AIM: In this study, we aimed to determine if the expression levels of the candidate biomarker caveolin-1 on stromal or tumour cells were associated with clinicopathological parameters and disease outcomes in TNBCs from an ethnically diverse cohort of Asian women...
July 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28734894/glce-rs3865014-val597ile-polymorphism-is-associated-with-breast-cancer-susceptibility-and-triple-negative-breast-cancer-in-siberian-population
#3
Valentina A Belyavskaya, Tatiana Y Prudnikova, Natalya V Domanitskaya, Nikolay V Litviakov, Vladimir N Maksimov, Nadezhda V Cherdyntseva, Elvira V Grigorieva
d-Glucuronyl C5-epimerase (GLCE) is one of key enzymes in heparan sulfate biosynthesis and possesses tumour-suppressor function in breast carcinogenesis. Here, we investigated a potential involvement of GLCE polymorphism(s) in breast cancer development in Siberian women population. Comprehensive analysis of SNP databases revealed GLCE rs3865014 (Val597Ile) missense polymorphism as the main significantly present in human populations. According the TaqMan-based SNP assay, allele distributions for the rs3865014 (A>G) were similar in healthy Siberian women (n=136) and cancer patients (n=129) (A0,73:G0,27) and intermediate between the European and Asian populations, while genotype distributions were different, with the increase of AG rate in breast cancer patients (OR=1...
July 19, 2017: Gene
https://www.readbyqxmd.com/read/28730914/the-health-economic-studies-of-hpv-vaccination-in-southeast-asian-countries-a-systematic-review
#4
Didik Setiawan, Monika Puri Oktora, Raymond Hutubessy, Arthorn Riewpaiboon, Maarten J Postma
The cervical cancer-related burden is an important problem in Southeast Asian (SEA) countries. However, only 3 out of 11 countries implement the comprehensive prevention program. Areas covered: This is a retrospective review from all relevant studies until 2015 from two main databases, MEDLINE/Pubmed and Embase in order to provide an evidence on the health economics of HPV vaccination in the region. Expert commentary: The implementation of HPV vaccination will generate substantial health and economic benefit in SEA countries since the number of cervical cancer cases in this region are generally high...
July 21, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28730704/the-athena-hpv-study-underrepresents-other-high-risk-hpv-genotypes-when-compared-with-a-diverse-new-york-city-population
#5
G Ramos Rivera, S N Khader, S Lajara, K Schlesinger, D Y Goldstein, R C Naeem, M J Suhrland, A S Fox
OBJECTIVE: Persistent infection with oncogenic high risk HPV (hrHPV) types causes virtually all cases of cervical cancer. HPV 16 and 18 have been targeted for individual genotyping and vaccination because of their presence in 71% of invasive cervical cancers worldwide. Montefiore Medical Center, Bronx, New York serves a population known for ethnic and racial diversity. Given this diversity it is possible that HPV genotypes not individually detected by current testing are causing significant disease...
July 21, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28730391/short-term-outcomes-in-minimally-invasive-versus-open-gastrectomy-the-differences-between-east-and-west-a-systematic-review-of-the-literature
#6
REVIEW
Nicole van der Wielen, Jennifer Straatman, Miguel A Cuesta, Freek Daams, Donald L van der Peet
OBJECTIVE: Minimally invasive surgical techniques for gastric cancer are gaining more interest worldwide. Several Asian studies have proven the benefits of minimally invasive techniques over the open techniques. Nevertheless, implementation of this technique in Western countries is gradual. The aim of this systematic review is to give insight in the differences in outcomes and patient characteristics in Asian countries in comparison to Western countries. METHODOLOGY: An extensive systematic search was conducted using the Medline, Embase, and Cochrane databases...
July 20, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28726018/association-of-vagotomy-and-decreased-risk-of-subsequent-ischemic-stroke-in-complicated-peptic-ulcer-patients-an-asian-population-study
#7
Chu-Wen Fang, Chun-Hung Tseng, Shih-Chi Wu, William Tzu-Liang Chen, Chih-Hsin Muo
OBJECTIVES: The primary management of peptic ulcers is medical treatment. Persistent exacerbation of a peptic ulcer may lead to complications (perforation and/or bleeding). There has been a trend toward the use of a less invasive surgical simple suture, simple local suture or non-operative (endoscopic/angiography) hemostasis rather than acid-reducing vagotomy (i.e., vagus nerve severance) for treating complicated peptic ulcers. Other studies have shown the relationship between high vagus nerve activity and survival in cancer patients via reduced levels of inflammation, indicating the essential role of the vagus nerve...
July 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28724665/the-c-1085a-g-genetic-variant-of-csf1r-gene-regulates-tumor-immunity-by-altering-the-proliferation-polarization-and-function-of-macrophages
#8
Yu-Min Yeh, Shan-Ju Hsu, Peng-Chan Lin, Keng-Fu Hsu, Pei-Ying Wu, Wu-Chou Su, Jang-Yang Chang, Meng-Ru Shen
Purpose: <p>Targeting tumor-associated macrophages with CSF-1R inhibition reveals a strategy for cancer therapy. Here, we studied the impact of CSF1R germline genetic variant on CSF-1R signaling and the susceptibility to CSF-1R inhibitors.</p> <p>Experimental designs: </p> <p>CSF1R germline genetic variants were studied in 140 cancer patients. CSF-1R phosphorylation, endocytosis and macrophage polarization were measured as the response to CSF-1 stimulation. Tumor-associated macrophages in surgical specimens and sensitivity to CSF-1R inhibitors were used to determine macrophage function...
July 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28723753/tumor-necrosis-factor-alpha-238g-a-polymorphism-and-risk-of-breast-cancer-an-update-by-meta-analysis
#9
Qing Zhang, Guang Sheng Zhao, Xiao Lin Yuan, Xiao Huan Li, Zhen Yang, Yi Fen Cui, Qing Lin Guan, Xiu Yan Sun, Wan Shen, Tai An Xu, Qiu Shi Wang
BACKGROUND: The association between the tumor necrosis factor-alpha gene (TNF-a) -238G/A polymorphism and the breast cancer has been analyzed in several studies, but the results have been inconclusive. We then performed a meta-analysis to get a precise estimation of the association. METHODS: Eight case-control studies with a total of 37,257 cases and 39,564 controls were identified by searching the ISI Web of Knowledge database and the PubMed database up to August 2014...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723620/association-between-8q24-rs6983267-polymorphism-and-cancer-susceptibility-a-meta-analysis-involving-170-737-subjects
#10
Man Zhu, Xue Wen, Xuefang Liu, Yingchao Wang, Chunzi Liang, Jiancheng Tu
Published data on the association between 8q24 rs6983267 polymorphism and cancer risk are inconsistent. Thus, we conducted a meta-analysis to evaluate the relationship between rs6983267 polymorphism and cancer risk. We searched on PubMed, EMBASE, Web of Science and China National Knowledge Infrastructure (CNKI) up to November 1, 2016 for relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of this association. We included 78 case-control studies with a total of 73,996 cases and 96,741 controls in this meta-analysis...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722680/prognostic-role-of-mir-17-92-family-in-human-cancers-evaluation-of-multiple-prognostic-outcomes
#11
REVIEW
Feifei Liu, Feng Zhang, Xiangyu Li, Qi Liu, Wei Liu, Peng Song, Ziying Qiu, Yu Dong, Hao Xiang
Recent evidence indicates that miR-17-92 family might be an essential prognostic biomarker for human cancers. However, results are still inconsistent. We therefore performed a meta-analysis to evaluate the predictive role of miR-17-92 family in human cancer prognosis. We searched literatures published before March 31th, 2017 inPubMed, Cochrane and Embase databases. Twenty six studies were included in our analyses. The overall hazard ratios (HRs) showed that high expression level of miR-17-92 family was a predictor of poor overall survival (OS): adjusted HRs = 1...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722678/optimal-adjuvant-chemotherapy-for-resected-pancreatic-adenocarcinoma-a-systematic-review-and-network-meta-analysis
#12
Jian-Bo Xu, Bin Jiang, Ya Chen, Fu-Zhen Qi, Jian-Huai Zhang, Hang Yuan
Adjuvant chemotherapy improves survival in patients with resected pancreatic cancer but the optimal regimen remains unclear. We aim to compare all possible adjuvant chemotherapy in terms of overall survival and toxic effects. Pubmed, Trial registries and Cochrane library databases for randomized controlled trials were searched until November 2016. Thirteen trials were included for network analysis and the hazard ratios (HRs) for survival and odds ratios for toxic effects were assessed via Aggregate Data Drug Information System software...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722672/ethnic-heterogeneity-and-prostate-cancer-mortality-in-hispanic-latino-men-a-population-based-study
#13
Felix M Chinea, Vivek N Patel, Deukwoo Kwon, Narottam Lamichhane, Chris Lopez, Sanoj Punnen, Erin N Kobetz, Matthew C Abramowitz, Alan Pollack
BACKGROUND: Few studies focus on prostate cancer (PCa) outcomes in Hispanic/Latino men. Our study explores whether Hispanic/Latino subgroups demonstrate significantly different prostate cancer-specific mortality (PCSM) relative to Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) men. METHODS: We extracted a population-based cohort of men diagnosed with local-regional PCa from 2000-2013 (n= 486,865). PCSM was measured in racial/ethnic groups: NHW (n=352,886), NHB (n= 70,983), Hispanic/Latino (n= 40,462), and Asian American/Pacific Islander (n= 22,534)...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28721894/predictors-of-positive-margins-after-definitive-resection-for-gastric-adenocarcinoma-and-impact-of-adjuvant-therapies
#14
Ryan M Rhome, Erin Moshier, Umut Sarpel, Nisha Ohri, Madhu Mazumdar, Michael H Buckstein
PURPOSE: Positive margins after definitive resection in gastric adenocarcinoma are associated with inferior outcomes. There are few randomized data to guide optimal adjuvant therapy after positive margins. METHODS: Using the National Cancer Database, we identified 24,619 nonmetastatic gastric adenocarcinoma patients who received diagnoses from 2004 to 2013 and underwent definitive resection to analyze for predictors of positive surgical margins. Of these patients, 2754 had positive margins (11...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721070/association-of-estrogen-receptor-%C3%AE-pvuii-and-xbai-polymorphisms-with-prostate-cancer-susceptibility-and-risk-stratification-a-meta-analysis-from-case-control-studies
#15
Yining Zhao, Xi Zheng, Lijie Zhang, Qiang Hu, Yitian Guo, Hua Jiang, Shennan Shi, Xiang Zhang
BACKGROUND: Studies on the association between two single nucleotide polymorphisms (SNPs) in estrogen receptor α (ERα), PvuII (rs2234693 T>C) and XbaI (rs9340799 A>G), and the prostate cancer risk are inconsistent. Therefore, we performed a meta-analysis to derive a more accurate estimation of this relationship. METHODS: A literature search of PubMed, Embase, Web of Science databases until October 1, 2016, was conducted. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of this association...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28720067/hpv16-e6-e7-upregulates-hif-2%C3%AE-and-vegf-by-inhibiting-lkb1-in-lung-cancer-cells
#16
Jian-Shuang Shao, Jian Sun, Shiyu Wang, Katherine Chung, Jin Tong Du, Jason Wang, Xue-Shan Qiu, En-Hua Wang, Guang-Ping Wu
Long-term persistent infection of HPV16 E6/E7 is frequently associated with lung cancers, especially in non-smokers and in Asians. However, molecular mechanisms of HPV16 E6/E7 induction of lung cancer are not fully understood. Using bi-directional genetic manipulation and four well-established lung cancer cell lines, we showed HPV16 E6/E7 downregulated expression of liver kinase B1 at both protein and messenger RNA levels; liver kinase B1 downregulated hypoxia-inducible factor 2α at protein level but not at messenger RNA level, and hypoxia-inducible factor 2α upregulated vascular endothelial growth factor at both protein and messenger RNA levels...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28719794/associations-of-breast-density-with-demographic-reproductive-and-lifestyle-factors-in-a-developing-southeast-asian-population
#17
Phuong Dung Yun Trieu, Claudia Mello-Thoms, Jennifer K Peat, Thuan Doan Do, Patrick C Brennan
The aim of this study was to investigate how breast density interacted with demographic, reproductive, and lifestyle features among Vietnamese women. Mammographic density and established risk factors for breast cancer were collected from 1651 women (345 cancer cases and 1306 normal cases) in Vietnam. The association of breast density categories with potential risk factors was investigated using Spearman's test for continuous variables and χ(2) tests for categorical variables. Independent factors associated with high breast density and breast cancer in specific density groupings were assessed using logistic regression...
July 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28718431/racial-differences-in-cancer-susceptibility-and-survival-more-than-the-color-of-the-skin
#18
REVIEW
Berna C Özdemir, Gian-Paolo Dotto
Epidemiological studies point to race as a determining factor in cancer susceptibility. In US registries recording cancer incidence and survival by race (distinguishing 'black versus white'), individuals of African ancestry have a globally increased risk of malignancies compared with Caucasians and Asian Americans. Differences in socioeconomic status and health-care access play a key role. However, the lesser disease susceptibility of Hispanic populations with comparable lifestyles and socioeconomic status as African Americans (Hispanic paradox) points to the concomitant importance of genetic determinants...
March 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28717853/radiation-related-heart-disease-after-breast-cancer-radiation-therapy-in-korean-women
#19
Jee Suk Chang, Byung Kyun Ko, Jeoung Won Bae, Jong-Han Yu, Min Ho Park, Yongsik Jung, Ye Won Jeon, Kyung Hwan Kim, Jaeyong Shin, Chang-Ok Suh, Yong Bae Kim
PURPOSE: To study the late cardiac toxicity of breast radiation therapy (RT) in Asian women. METHODS: Female breast cancer patients in Korea who underwent breast conservation surgery followed by RT from 1990-2012 were identified from two large registries at institution and population levels. Cumulative incidences of acute coronary events (ACE) or cardiac mortality were estimated in relation to the laterality of breast cancer using a competing risks analysis. RESULTS: In an analysis of 2577 women from a single institution, 3...
July 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28717762/epidermal-growth-factor-receptor-mutational-status-and-brain-metastases-in-non-small-cell-lung-cancer
#20
Vijaya Raj Bhatt, Sanyo P D'Souza, Lynette M Smith, Allison M Cushman-Vokoun, Vanita Noronha, Vivek Verma, Amit Joshi, Anuradha Chougule, Nirmala Jambhekar, Anne Kessinger, Alissa Marr, Vijay Patil, Sripad D Banavali, Apar Kishor Ganti, Kumar Prabhash
INTRODUCTION: Epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancers (NSCLC) may be more common in patients with brain metastases. Previous studies, however, did not adjust for effects of confounding variables. METHODS: This retrospective study included 1,522 consecutive patients with NSCLC, whose tumors were diagnosed and tested for EGFR mutations at the University of Nebraska Medical Center (Omaha, NE) and Tata Memorial Hospital (Mumbai, India)...
June 2017: Journal of Global Oncology
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