Svitlana Drozdovska, Nadège Zanou, Jessica Lavier, Lucia Mazzolai, Grégoire P Millet, Maxime Pellegrin
The muscle molecular adaptations to different exercise intensities in combination with hypoxia are not well understood. This study investigated the effect of low- and supramaximal-intensity hypoxic training on muscle metabolic gene expression in mice. C57BL/6 mice were divided into two groups: sedentary and training. Training consisted of 4 weeks at low or supramaximal intensity, either in normoxia or hypoxia (FiO2 = 0.13). The expression levels of genes involved in the hypoxia signaling pathway ( Hif1a and Vegfa ), the metabolism of glucose ( Gys1 , Glut4 , Hk2 , Pfk , and Pkm1 ), lactate ( Ldha , Mct1 , Mct4 , Pdh , and Pdk4 ) and lipid ( Cd36 , Fabp3 , Ucp2 , Hsl , and Mcad ), and mitochondrial energy metabolism and biogenesis ( mtNd1 , mtNd6 , CytC , CytB , Pgc1a , Pgc1β , Nrf1 , Tfam , and Cs ) were determined in the gastrocnemius muscle...
October 21, 2023: Metabolites