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https://www.readbyqxmd.com/read/29470948/direct-analysis-of-pi-3-4-5-p-3-using-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#1
Hai H Bui, Phillip E Sanders, Diane Bodenmiller, Ming Shang Kuo, Gregory P Donoho, Anthony S Fischl
Phosphatidylinositol (3,4,5) trisphosphate (PIP3 ) is a biologically active membrane phospholipid that is essential for the growth and survival of all eukaryotic cells. We describe a new method that directly measures PIP3 and describe the HPLC separation and measurement of the positional isomers of phosphatidylinositol bisphosphate, PI(3,5)P2 , PI(3,4)P2 and PI(4,5)P2 . Mass spectrometric analyses were performed online using ultra-high performance liquid chromatography (UHPLC)-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) in the negative multiple-reaction monitoring (MRM) modes...
February 19, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29470747/solid-stress-facilitates-fibroblasts-activation-to-promote-pancreatic-cancer-cell-migration
#2
Maria Kalli, Panagiotis Papageorgis, Vasiliki Gkretsi, Triantafyllos Stylianopoulos
Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated fibroblasts can acquire an activated phenotype and produce excessive amounts of extracellular matrix creating a highly dense stroma, a situation known as desmoplasia. Desmoplasia, along with the uncontrolled proliferation of cancer cells, leads to the development of compressive forces within the tumor, generating the so-called solid stress...
February 22, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29470349/impaired-secretion-of-tnf-%C3%AE-by-monocytes-stimulated-with-ebv-peptides-associates-with-infectious-complications-following-kidney-transplantation
#3
Patrice Vallin, Olivier Désy, Stéphanie Béland, François Bouchard-Boivin, Isabelle Houde, S A De Serres
BACKGROUND: The successful development of immunosuppressive agents has paradoxically led to an era in which adverse effects of immunosuppression, such as infections and cancer, are now a major concern in solid organ recipients. Nevertheless, the main focus of immune monitoring research remains the identification of rejection. There is currently no clinical tool to assess the net state of immunosuppression or to identify patients at increased risk of infectious complications. METHODS: We report a prospective, longitudinal study in which we conducted detailed phenotyping of over 300 peripheral blood mononuclear cell samples from 45 kidney recipients during the first 24 months posttransplant...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29469819/the-long-noncoding-rna-hotair-in-breast-cancer-does-autophagy-play-a-role
#4
Elżbieta Pawłowska, Joanna Szczepanska, Janusz Blasiak
HOTAIR (HOX transcript antisense RNA) plays a critical role in chromatin dynamics through the interaction with histone modifiers resulting in transcriptional gene silencing. The promoter of the HOTAIR gene contains multiple estrogen response elements (EREs) and is transcriptionally activated by estradiol in estrogen receptor-positive breast cancer cells. HOTAIR competes with BRCA1, a critical protein in breast cancer and is a critical regulator of genes involved in epithelial-to-mesenchymal transition. It mediates an oncogenic action of c-Myc, essential for breast carcinogenesis...
November 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29468929/tumor-derived-lactate-induces-m2-macrophage-polarization-via-the-activation-of-the-erk-stat3-signaling-pathway-in-breast-cancer
#5
Xianmin Mu, Wei Shi, Yue Xu, Che Xu, Ting Zhao, Biao Geng, Jing Yang, Jinshun Pan, Shi Hu, Chen Zhang, Juan Zhang, Chao Wang, Jiajia Shen, Yin Che, Zheng Liu, Yuanfang Lv, Hao Wen, Qiang You
Tumor-associated macrophages (TAM) are prominent components of tumor microenvironment (TME) and capable of promoting cancer progression. However, the mechanisms for the formation of M2-like TAMs remain enigmatic. Here, we show that lactate is a pivotal oncometabolite in the TME that drives macrophage M2-polarization to promote breast cancer proliferation, migration, and angiogenesis. In addition, we identified that the activation of ERK/ STAT3, major signaling molecules in the lactate signaling pathway, deepens our molecular understanding of how lactate educates TAMs...
February 22, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29468927/inducible-co-stimulator-icos-as-a-potential-therapeutic-target-for-anti-cancer-therapy
#6
Florent Amatore, Laurent Gorvel, Daniel Olive
The recent success of checkpoint-inhibitors in cancer treatment paved the way for the development of new strategies of agonist and antagonist agents against B7 superfamily members. Inducible Co-Stimulator (ICOS), a co-stimulatory receptor for T-cell enhancement, arouses interest. Areas covered: We performed an extensive literature search with PUBMED using the keywords 'ICOS' and 'cancer' to discuss its involvement in oncogenesis, its expression in different malignancies, and its targeting in relevant preclinical studies...
February 22, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29468843/gpcr6a-is-a-molecular-target-for-the-natural-products-gallate-and-egcg-in-green-tea
#7
Min Pi, Karan Kapoor, Ruisong Ye, Jeremy C Smith, Jerome Baudry, L Darryl Quarles
SCOPE: The molecular mechanisms whereby gallates in green tea exert metabolic effects are poorly understood. METHODS AND RESULTS: We found that GPRC6A, a multi-ligand sensing G-protein coupled receptor that regulates energy metabolism, sex hormone production and prostate cancer progression, is a target for gallates. Sodium gallate,1 gallic acid (GA) > ethyl gallate (EG) > octyl gallate (OG) dose dependently activated ERK in HEK-293 cells transfected with GPRC6A but not in non-transfected controls...
February 21, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29468142/-helicobacter-pylori-type-iv-secretion-system-and-its-adhesin-subunit-cagl-mediate-potent-inflammatory-responses-in-primary-human-endothelial-cells
#8
Mona Tafreshi, Jyeswei Guan, Rebecca J Gorrell, Nicole Chew, Yue Xin, Virginie Deswaerte, Manfred Rohde, Roger J Daly, Richard M Peek, Brendan J Jenkins, Elizabeth M Davies, Terry Kwok
The Gram-negative bacterium, Helicobacter pylori , causes chronic gastritis, peptic ulcers, and gastric cancer in humans. Although the gastric epithelium is the primary site of H. pylori colonization, H. pylori can gain access to deeper tissues. Concurring with this notion, H. pylori has been found in the vicinity of endothelial cells in gastric submucosa. Endothelial cells play crucial roles in innate immune response, wound healing and tumorigenesis. This study examines the molecular mechanisms by which H...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29467931/toll-like-receptor-2-induces-adenosine-receptor-a2a-and-promotes-human-squamous-carcinoma-cell-growth-via-extracellular-signal-regulated-kinases-%C3%A2
#9
Chithra Devi Palani, Lalitha Ramanathapuram, Aroonwan Lam-Ubol, Zoya B Kurago
Patient treatment for oral squamous cell carcinoma (OSCC) not associated with Human papillomavirus remains problematic. OSCC microenvironment is typically inflamed and colonized by microorganisms, providing ligands for toll-like receptors (TLR). In immune cells TLR2 and TLR4 activate NF-kB and extracellular signal regulated kinase (ERK)1/2 pathways, leading to upregulation of inhibitory adenosine receptors A2a and A2b, and reduction in stimulatory A1 and A3. How TLR and adenosine receptors function in SCC cells is not understood...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467899/tnf-%C3%AE-promotes-colon-cancer-cell-migration-and-invasion-by-upregulating-trop-2
#10
Peng Zhao, Zhongtao Zhang
High levels of tumor-associated calcium signal transduction protein (TROP)-2 have been demonstrated to be strongly associated with tumor necrosis factor (TNF)-α levels in colon cancer. In the present study, the effect of TNF-α on the regulation of TROP-2 expression and its effect in colon cancer cell migration and invasion were investigated in vitro . TROP-2 protein levels were evaluated in HCT-116 human colon cancer cells cultured with various concentrations of TNF-α using western blot analysis. Changes in the migratory and invasive potential of the cells were evaluated using a wound healing and transwell assay, respectively...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467893/ifn-%C3%AE-induces-the-upregulation-of-rfxap-via-inhibition-of-mir-212-3p-in-pancreatic-cancer-cells-a-novel-mechanism-for-ifn-%C3%AE-response
#11
Guoping Ding, Liangjing Zhou, Tao Shen, Liping Cao
Previous studies have demonstrated that pancreatic cancer-derived microRNA (miR)-212-3p can inhibit the expression of regulatory factor X-associated protein (RFXAP), an important transcription factor for major histocompatibility complex (MHC) class II, and thereby lead to downregulation of MHC class II in dendritic cells. It has also been established that interferon (IFN)-γ can increase the expression of MHC class II in immune cells. It was therefore hypothesized that IFN-γ can inhibit miR-212-3p expression in pancreatic cancer, leading to the upregulation of RFXAP and MHC class II expression...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467761/establishment-of-the-reference-intervals-of-lymphocyte-function-in-healthy-adults-based-on-ifn-%C3%AE-secretion-assay-upon-phorbol-12-myristate-13-acetate-ionomycin-stimulation
#12
Hongyan Hou, Yu Zhou, Jing Yu, Lie Mao, Munyemana Jean Bosco, Juan Wang, Yanfang Lu, Liyan Mao, Xiaohui Wu, Feng Wang, Ziyong Sun
The function of lymphocytes is the key to reflect the immune status of hosts. Evaluation of lymphocyte function is a useful tool to monitor the effect of immunosuppressive treatment and predict the prognosis of immune-mediated diseases (e.g., cancer, autoimmune diseases, and infectious diseases). As the lymphocytes have various activities, such as activation, cytotoxicity, and cytokine secretion, it is a challenge to evaluate the function of lymphocytes in clinical practice and the reference intervals (RIs) of lymphocyte function are rarely reported...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29467584/pcornet-s-collaborative-research-groups
#13
EDITORIAL
Mark J Pletcher, Christopher B Forrest, Thomas W Carton
The Patient-Centered Outcomes Research Institute (PCORI) launched a multi-institutional "network of networks" in 2013 - Patient-Centered Clinical Research Network (PCORnet) - that is designed to conduct clinical research that is faster, less expensive, and more responsive to the information needs of patients and clinicians. To enhance cross-network and cross-institutional collaboration and catalyze the use of PCORnet, PCORI has supported formation of 11 Collaborative Research Groups focusing on specific disease types (e...
2018: Patient related Outcome Measures
https://www.readbyqxmd.com/read/29467274/jak2-inhibitor-sar302503-abrogates-pd-l1-expression-and-targets-therapy-resistant-non-small-cell-lung-cancers
#14
Sean Pitroda, Melinda Stack, Gene-Fu Liu, Sui-Sui Song, Lucy Chen, Hua Liang, Akash D Parekh, Xiaona Huang, Paul B Roach, Mitchell C Posner, Ralph R Weichselbaum, Nikolai N Khodarev
Lung cancer is the leading cause of cancer deaths worldwide. Approximately 85% of all lung cancers are non-small-cell histology (NSCLC). Modern treatment strategies for NSCLC target driver oncogenes and immune checkpoints. However, less than fifteen percent of patients survive beyond five years. Here, we investigated the effects of SAR302503 (SAR), a selective JAK2 inhibitor, on NSCLC cell lines and tumors. We show that SAR is cytotoxic to NSCLC cells which exhibit resistance to genotoxic therapies, such as ionizing radiation, cisplatin, and etoposide...
February 21, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29467166/polarised-epithelial-monolayers-of-the-gastric-mucosa-reveal-insights-into-mucosal-homeostasis-and-defence-against-infection
#15
Francesco Boccellato, Sarah Woelffling, Aki Imai-Matsushima, Gabriela Sanchez, Christian Goosmann, Monika Schmid, Hilmar Berger, Pau Morey, Christian Denecke, Juergen Ordemann, Thomas F Meyer
OBJECTIVE: Helicobacter pylori causes life-long colonisation of the gastric mucosa, leading to chronic inflammation with increased risk of gastric cancer. Research on the pathogenesis of this infection would strongly benefit from an authentic human in vitro model. DESIGN: Antrum-derived gastric glands from surgery specimens served to establish polarised epithelial monolayers via a transient air-liquid interface culture stage to study cross-talk with H. pylori and the adjacent stroma...
February 21, 2018: Gut
https://www.readbyqxmd.com/read/29466808/impact-of-green-tea-catechin-ecg-and-its-synthesized-fluorinated-analogue-on-prostate-cancer-cells-and-stimulated-immunocompetent-cells
#16
Sven Stadlbauer, Carmen Steinborn, Amy Klemd, Fumihiko Hattori, Ken Ohmori, Keisuke Suzuki, Roman Huber, Philipp Wolf, Carsten Gründemann
Among the known or suspected risk factors, inflammation plays an important role in infectious and non-infectious pathways leading to cancer. Green tea polyphenols have been associated with reducing inflammation and protection against carcinogenesis, especially in prostate cancer. While most of the research in this field, so far, has focussed on epigallocatechin-3- O -gallate only, we studied epicatechin-3- O -gallate, the second most abundant green tea polyphenol with essential therapeutic potential, to obtain a more detailed understanding of its anti-tumor and anti-inflammatory action...
February 21, 2018: Planta Medica
https://www.readbyqxmd.com/read/29466089/photobiomodulation-and-cancer-what-is-the-truth
#17
Michael R Hamblin, Scott T Nelson, Justin R Strahan
BACKGROUND: Photobiomodulation (PBM) therapy is a rapidly growing approach to stimulate healing, reduce pain, increase athletic performance, and improve general wellness. OBJECTIVE: Applying PBM therapy over the site of a tumor has been considered to be a contraindication. However, since another growing use of PBM therapy is to mitigate the side effects of cancer therapy, this short review seeks to critically examine the evidence of whether PBM therapy is beneficial or harmful in cancer patients...
February 21, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29466034/astragalus-saponins-and-liposome-constitute-an-efficacious-adjuvant-formulation-for-cancer-vaccines
#18
Xiao-Ping Zhang, Ying-Dong Li, Lu-Lu Luo, Yong-Qi Liu, Yang Li, Chao Guo, Zhen-Dong Li, Xiao-Rong Xie, Hai-Xia Song, Li-Ping Yang, Shao-Bo Sun, Fang-Yu An
Cancer vaccines mostly aim to induce cytotoxic T lymphocytes (CTLs) against tumors. An appropriate adjuvant is of fundamental importance for inducing cellular immune response. Since the antigen in particulate form is substantially more immunogenic than soluble form antigen, it is beneficial to interact with antigen-presenting cells membrane to induce robust CD8+ T cell activation following vaccination. Based on previous research, we designed an adjuvant formulation by combining Astragalus saponins, cholesterol, and liposome to incorporate antigen into a particulate delivery system, so as to enhance cellular immune response...
February 2018: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29465116/polyphenols-rich-extract-from-pleurotus-eryngii-with-growth-inhibitory-of-hct116-colon-cancer-cells-and-anti-inflammatory-function-in-raw264-7-cells
#19
Qiuhui Hu, Biao Yuan, Hang Xiao, Liyan Zhao, Xian Wu, Kanyasiri Rakariyatham, Lei Zhong, Yanhui Han, Benard Muinde Kimatu, Wenjian Yang
Edible mushrooms are rich sources of bioactive components. In this study, a polyphenol-rich extract, designated as PPEP, was isolated from an edible mushroom, Pleurotus eryngii. Using ultra high performance liquid chromatograph combined with triple time-of-flight mass spectrometry (UPLC-TOF/MS/MS), gallic acid monohydrate, 3-(3,4-dihydroxyphenyl)-propionic acid, methyl gallate, syringic acid, ellagic acid and catechin were identified in PPEP. This phenolic-rich extract PPEP exhibited anti-inflammatory effect in lipopolysaccharide-stimulated RAW264...
February 21, 2018: Food & Function
https://www.readbyqxmd.com/read/29464567/mitochondrial-proteolipid-complexes-of-creatine-kinase
#20
Uwe Schlattner, Laurence Kay, Malgorzata Tokarska-Schlattner
Isoforms of creatine kinase (CK) generate and use phosphocreatine, a concentrated and highly diffusible cellular "high energy" intermediate, for the main purpose of energy buffering and transfer in order to maintain cellular energy homeostasis. The mitochondrial CK isoform (mtCK) localizes to the mitochondrial intermembrane and cristae space, where it assembles into peripherally membrane-bound, large cuboidal homooctamers. These are part of proteolipid complexes wherein mtCK directly interacts with cardiolipin and other anionic phospholipids, as well as with the VDAC channel in the outer membrane...
2018: Sub-cellular Biochemistry
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