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https://www.readbyqxmd.com/read/29245176/high-risk-of-hypogonadism-in-young-male-cancer-survivors
#1
S Isaksson, K Bogefors, O Ståhl, J Eberhard, Y Lundberg Giwercman, I Leijonhufvud, K Link, I Øra, P Romerius, J Bobjer, A Giwercman
OBJECTIVE: Cancer and its treatment in childhood and young adulthood can cause hypogonadism, leading to increased risk of long term morbidity and mortality. The aim of this study was to evaluate the risk of presenting with biochemical signs of hypogonadism in testicular cancer survivors (TCS) and male childhood cancer survivors (CCS) in relation to the type of treatment given. DESIGN: Case-control study. PATIENTS: Ninety-two TCS, 125 CCS (mean age 40 and median age 34 years, respectively; mean follow-up time 9...
December 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29243219/pd-1-blockade-enhances-the-anti-tumor-efficacy-of-gm-csf-surface-modified-bladder-cancer-stem-cells-vaccine
#2
Xiaojun Shi, Xinji Zhang, Jinlong Li, Lijun Mo, Hongfan Zhao, Yongtong Zhu, Zhiming Hu, Jimin Gao, Wanlong Tan
Eliminating cancer stem cells (CSCs) is a key issue in eradicating tumor. The streptavidin-granulocyte -macrophage colony stimulating factor (SA-GM-CSF) surface-modified bladder cancer stem cells vaccine previously developed using our protein-anchor technology could effectively induce specific immune response for eliminating CSCs. However, program death receptor-1 (PD-1)/program death ligand 1 (PD-L1) signaling in tumor microenvironment results in tumor adaptive immune resistance. Although the CSCs vaccine could increase the number of CD8+ T-cells, a part of these CD8+ T-cells expressed PD-1...
December 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29243000/rna-interference-based-therapy-and-its-delivery-systems
#3
Xiuhui Chen, Lingegowda S Mangala, Cristian Rodriguez-Aguayo, Xianchao Kong, Gabriel Lopez-Berestein, Anil K Sood
RNA interference (RNAi) is considered a highly specific approach for gene silencing and holds tremendous potential for treatment of various pathologic conditions such as cardiovascular diseases, viral infections, and cancer. Although gene silencing approaches such as RNAi are widely used in preclinical models, the clinical application of RNAi is challenging primarily because of the difficulty in achieving successful systemic delivery. Effective delivery systems are essential to enable the full therapeutic potential of RNAi...
December 14, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/29242535/lipid-bodies-containing-oxidatively-truncated-lipids-block-antigen-cross-presentation-by-dendritic-cells-in-cancer
#4
Filippo Veglia, Vladimir A Tyurin, Dariush Mohammadyani, Maria Blasi, Elizabeth K Duperret, Laxminarasimha Donthireddy, Ayumi Hashimoto, Alexandr Kapralov, Andrew Amoscato, Roberto Angelini, Sima Patel, Kevin Alicea-Torres, David Weiner, Maureen E Murphy, Judith Klein-Seetharaman, Esteban Celis, Valerian E Kagan, Dmitry I Gabrilovich
Cross-presentation is a critical function of dendritic cells (DCs) required for induction of antitumor immune responses and success of cancer immunotherapy. It is established that tumor-associated DCs are defective in their ability to cross-present antigens. However, the mechanisms driving these defects are still unknown. We find that impaired cross-presentation in DCs is largely associated with defect in trafficking of peptide-MHC class I (pMHC) complexes to the cell surface. DCs in tumor-bearing hosts accumulate lipid bodies (LB) containing electrophilic oxidatively truncated (ox-tr) lipids...
December 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29242512/synthetic-integrin-binding-immune-stimulators-target-cancer-cells-and-prevent-tumor-formation
#5
Manuel Brehs, André J G Pötgens, Julia Steitz, Karine Thewes, Janett Schwarz, Anne C Conibear, Matthias Bartneck, Frank Tacke, Christian F W Becker
Immuno-oncology approaches mainly utilize monoclonal antibodies or protein-based scaffolds that bind with high affinity to cancer cells and can generate an immune response. Peptides can also bind with high affinity to cancer cells and are intermediate in size between antibodies and small molecules. They are also synthetically accessible and therefore easily modified to optimize their stability, binding affinity and selectivity. Here we describe the design of immune system engagers (ISErs), a novel class of synthetic peptide-based compounds that bind specifically to cancer cells and stimulate the immune system...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29241445/shifting-cancer-care-towards-multidisciplinarity-the-cancer-center-certification-program-of-the-german-cancer-society
#6
Christoph Kowalski, Ullrich Graeven, Christof von Kalle, Hauke Lang, Matthias W Beckmann, Jens-Uwe Blohmer, Martin Burchardt, Michael Ehrenfeld, Jan Fichtner, Stephan Grabbe, Hans Hoffmann, Heinrich Iro, Stefan Post, Anton Scharl, Uwe Schlegel, Thomas Seufferlein, Walter Stummer, Dieter Ukena, Julia Ferencz, Simone Wesselmann
BACKGROUND: Over the last decades numerous initiatives have been set up that aim at translating the best available medical knowledge and treatment into clinical practice. The inherent complexity of the programs and discrepancies in the terminology used make it difficult to appreciate each of them distinctly and compare their specific strengths and weaknesses. To allow comparison and stimulate dialogue between different programs, we in this paper provide an overview of the German Cancer Society certification program for multidisciplinary cancer centers that was established in 2003...
December 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29239517/nanoparticulate-delivery-of-cancer-cell-membrane-elicits-multiantigenic-antitumor-immunity
#7
Ashley V Kroll, Ronnie H Fang, Yao Jiang, Jiarong Zhou, Xiaoli Wei, Chun Lai Yu, Jie Gao, Brian T Luk, Diana Dehaini, Weiwei Gao, Liangfang Zhang
Anticancer vaccines train the body's own immune system to recognize and eliminate malignant cells based on differential antigen expression. While conceptually attractive, clinical efficacy is lacking given several key challenges stemming from the similarities between cancerous and healthy tissue. Ideally, an effective vaccine formulation would deliver multiple tumor antigens in a fashion that potently stimulates endogenous immune responses against those antigens. Here, it is reported on the fabrication of a biomimetic, nanoparticulate anticancer vaccine that is capable of delivering autologously derived tumor antigen material together with a highly immunostimulatory adjuvant...
December 2017: Advanced Materials
https://www.readbyqxmd.com/read/29238724/dna-damage-as-a-driver-for-growth-delay-chromosome-instability-syndromes-with-intrauterine-growth-retardation
#8
REVIEW
Benilde García-de Teresa, Mariana Hernández-Gómez, Sara Frías
DNA is constantly exposed to endogenous and exogenous mutagenic stimuli that are capable of producing diverse lesions. In order to protect the integrity of the genetic material, a wide array of DNA repair systems that can target each specific lesion has evolved. Despite the availability of several repair pathways, a common general program known as the DNA damage response (DDR) is stimulated to promote lesion detection, signaling, and repair in order to maintain genetic integrity. The genes that participate in these pathways are subject to mutation; a loss in their function would result in impaired DNA repair and genomic instability...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29238337/the-role-of-type-2-diabetes-for-the-development-of-pathogen-associated-cancers-in-the-face-of-the-hiv-aids-epidemic
#9
REVIEW
Melissa J Blumenthal, Sylvia Ujma, Arieh A Katz, Georgia Schäfer
The contribution of HIV to the development of pathogen-associated cancers has long been recognized, as has the contribution of type 2 diabetes for the development of several types of cancer. While HIV/AIDS-associated immunosuppression reduces immunosurveillance and indirectly contributes favorably to cancerogenesis, diabetes directly increases cancer development due to chronic low-grade inflammation, dysregulated glucose metabolism, hyperactivation of insulin-responsive pathways, and anti-apoptotic signaling...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29238273/dual-effects-of-n-n-dimethylformamide-on-cell-proliferation-and-apoptosis-in-breast-cancer
#10
Jihong Zhang, Daibing Zhou, Lingyun Zhang, Qunbo Lin, Weimin Ren, Jinguo Zhang, Lubna Nadeem, Guoxiong Xu
N,N-dimethylformamide (DMF) has been widely used as an organic solvent in industries. DMF is a potential medication. However, the antitumorigenic role of DMF in breast cancer remains unclear. Here, we examined dose-dependent effects of DMF on proliferation and apoptosis in breast cancer MCF-7 and nontumorous MCF-12A cells. We found that DMF had a growth inhibitory effect in MCF-12A cells in a dose-dependent manner. By contrast, however, DMF had dual effects on cell proliferation and apoptosis in MCF-7 cells...
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29238266/erythropoietin-promoted-the-proliferation-of-hepatocellular-carcinoma-through-hypoxia-induced-translocation-of-its-specific-receptor
#11
Shuo Miao, Su-Mei Wang, Xue Cheng, Yao-Feng Li, Qing-Song Zhang, Gang Li, Song-Qing He, Xiao-Ping Chen, Ping Wu
Background: Erythropoietin (EPO) is a hypoxia-inducible stimulator of erythropoiesis. Besides its traditional application in anemia therapy, it offers an effective treatment in the cancer patients, especially those who receive chemotherapy. Several reports indicated that it could promote the tumor cell proliferation through its specific receptor (EPOR). Unfortunately, the role of EPO/EPOR in hepatocellular carcinoma (HCC) progressing is still uncertain. Methods: Protein in tumor tissue from HCC patients or H22 tumor-bearing mice was detected with immunohistochemistry...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29238068/microrna-105-is-involved-in-tnf-%C3%AE-related-tumor-microenvironment-enhanced-colorectal-cancer-progression
#12
Zetao Shen, Rui Zhou, Chen Liu, Yaofeng Wang, Wanqi Zhan, Ziyun Shao, Jian Liu, Feifei Zhang, Lijun Xu, Xinying Zhou, Lu Qi, Feng Bo, Yanqing Ding, Liang Zhao
TNF-α is a central proinflammatory cytokine contributing to malignant tumor progression in tumor microenvironment. In this study, we found the upregulation of miR-105 in colorectal cancer was associated with aggressive phenotype, and the enhanced expression of miR-105 was required for TNF-α-induced epithelial-mesenchymal transition (EMT). The expression of miR-105 was remarkably stimulated by TNF-α in a time-dependent manner using real-time qPCR analysis. Inhibition of miR-105 remarkably weakened the aggressive effects of TNF-α through preventing the activation of NF-κB signaling and the initiation of EMT...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29238047/negative-control-of-the-hgf-c-met-pathway-by-tgf-%C3%AE-a-new-look-at-the-regulation-of-stemness-in-glioblastoma
#13
Eleanna Papa, Michael Weller, Tobias Weiss, Elisa Ventura, Isabel Burghardt, Emese Szabó
Multiple target inhibition has gained considerable interest in combating drug resistance in glioblastoma, however, understanding the molecular mechanisms of crosstalk between signaling pathways and predicting responses of cancer cells to targeted interventions has remained challenging. Despite the significant role attributed to transforming growth factor (TGF)-β family and hepatocyte growth factor (HGF)/c-MET signaling in glioblastoma pathogenesis, their functional interactions have not been well characterized...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29237905/a-clinical-study-of-polyethylene-glycol-recombinant-human-granulocyte-colony-stimulating-factor-prevention-neutropenia-syndrome-in-patients-with-esophageal-carcinoma-and-lung-cancer-after-concurrent-chemoradiotherapy
#14
Fang Liu, Yu Du, Boning Cai, Maohui Yan, Wei Yang, Qianqian Wang
OBJECTIVE: To compare the efficacy and safety of PEG-rhG-CSF and recombinant human G-CSF (rhG-CSF) for the prevention and delayed application in febrile neutropenia, hospitalization rate in concurrent chemoradiotherapy of tumors. METHODS: A total of 163 patients, who received concurrent chemoradiotherapy for solid tumors. There were 75 patients in the PEG-rhG-CSF group (PEG group), who received 146 cycles of concurrent chemoradiotherapy, of which 132 cycles (90...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29237719/ift20-modulates-ciliary-pdgfr%C3%AE-signaling-by-regulating-the-stability-of-cbl-e3-ubiquitin-ligases
#15
Fabian Marc Schmid, Kenneth Bødtker Schou, Martin Juel Vilhelm, Maria Schrøder Holm, Loretta Breslin, Pietro Farinelli, Lars Allan Larsen, Jens Skorstengaard Andersen, Lotte Bang Pedersen, Søren Tvorup Christensen
Primary cilia have pivotal roles as organizers of many different signaling pathways, including platelet-derived growth factor receptor α (PDGFRα) signaling, which, when aberrantly regulated, is associated with developmental disorders, tumorigenesis, and cancer. PDGFRα is up-regulated during ciliogenesis, and ciliary localization of the receptor is required for its appropriate ligand-mediated activation by PDGF-AA. However, the mechanisms regulating sorting of PDGFRα and feedback inhibition of PDGFRα signaling at the cilium are unknown...
December 13, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/29237091/epidermodysplasia-verruciformis-in-an-adult-patient-with-a-germline-itk-mutation-and-lymphoma-the-case-of-inherited-versus-acquired
#16
S Fouéré, F Aubin, H Péré, L Galicier, T Gheit, M Tommasino, C Ram Wolff, D Boutboul, M Bagot
Epidermodysplasia verruciformis (EV) is characterized by a clinically distinctive pattern of beta-HPV induced flat warts that may evolve into epithelial skin cancers. The current understanding is that EV encompasses two etiological situations: Classic, inherited type EV (IEV), beginning in childhood or adolescence, due to Trans Membrane Channel (TMC) - 6 and 7 (EVER-1 and 2) gene mutations 75% of patients, or to alterations resulting in T-Cell immune deficiencies (IDs) on Ras Homolog Family Member H (RHOH), Coronin 1A (CORO 1A), Macrophage Stimulating factor 1 (MST-1), or interleukin 7 (IL7) genes...
December 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29236523/associations-between-inflammatory-bowel-diseases-and-vitamin-d
#17
Sandra Maria Barbalho, Ricardo de Alvares Goulart, Rodrigo Gallhardi Gasparini
Inflammatory Bowel Diseases (IBD) are increasing sharply, and the common medications are not effective for most patients. Vitamin D (VD) has been considerate to reduce inflammatory processes and may be helpful in IBD. The aim of this review was to perform an update on the potential role of VD in the IBD. We performed a search for articles associating VD and IBD published in MEDLINE-PubMed and EMBASE. The focused question used for the search was "What is the association between Inflammatory Bowel Disease and Vitamin D?" The exclusion criteria for this search were studies not in English, editorials, case reports, or poster presentations...
December 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29235459/pi3k%C3%AE-activates-e2f1-synthesis-in-response-to-mrna-translation-stress
#18
Sivakumar Vadivel Gnanasundram, Slovénie Pyndiah, Chrysoula Daskalogianni, Kate Armfield, Karin Nylander, Joanna B Wilson, Robin Fåhraeus
The c-myc oncogene stimulates ribosomal biogenesis and protein synthesis to promote cellular growth. However, the pathway by which cells sense and restore dysfunctional mRNA translation and how this is linked to cell proliferation and growth is not known. We here show that mRNA translation stress in cis triggered by the gly-ala repeat sequence of Epstein-Barr virus (EBV)-encoded EBNA1, results in PI3Kδ-dependent induction of E2F1 mRNA translation with the consequent activation of c-Myc and cell proliferation...
December 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29235378/the-hexane-fraction-of-bursera-microphylla-a-gray-induces-p21-mediated-anti-proliferative-and-pro-apoptotic-effects-in-human-cancer-derived-cell-lines
#19
Sabrina Adorisio, Alessandra Fierabracci, Giulia Gigliarelli, Isabella Muscari, Lorenza Cannarile, Anna Marina Liberati, Maria Carla Marcotullio, Carlo Riccardi, Massimo Curini, Ramon Enrique Robles Zepeda, Domenico V Delfino
Bursera microphylla (BM), one of the common elephant trees, is widely distributed in the Sonoran Desert in Mexico. The Seri ethnic group in the Sonoran Desert uses BM as an anti-inflammatory and painkiller drug for the treatment of sore throat, herpes labialis, abscessed tooth, and wound healing. Dried stems and leaves of BM are used in a tea to relieve painful urination and to stimulate bronchial secretion. Furthermore, BM is used for fighting venereal diseases. To investigate the effects of the hexane fraction of resin methanol extract (BM-H) on cell growth, the acute myeloid cell line (OCI-AML3) was treated with 250, 25, or 2...
March 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29235095/immune-cells-regulate-vegf-signaling-via-release-of-vegf-and-antagonistic-soluble-vegf-receptor-1
#20
Timm Hoeres, Martin Wilhelm, Manfred Smetak, Elisabeth Holzmann, Gundula Schulze-Tanzil, Josef Birkmann
Vascular endothelial growth factor (VEGF) is an important regulator of physiological and pathological angiogenesis. Beside malignant and stromal cells, local immune cells shape VEGF signaling in the tumor microenvironment. Aminobisphosphonates like zoledronic acid (Zol) are drugs known to inhibit osteoclast activity and bone resorption, but also have immunomodulatory and anti-tumor effects. These properties have previously been linked to the downregulation of VEGF and interference with tumor neo-angiogenesis...
December 13, 2017: Clinical and Experimental Immunology
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