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https://www.readbyqxmd.com/read/29050199/pre-clinical-pharmacology-of-azd3965-a-selective-inhibitor-of-mct1-dlbcl-nhl-and-burkitt-s-lymphoma-anti-tumor-activity
#1
Nicola J Curtis, Lorraine Mooney, Lorna Hopcroft, Filippos Michopoulos, Nichola Whalley, Haihong Zhong, Clare Murray, Armelle Logie, Mitchell Revill, Kate F Byth, Amanda D Benjamin, Mike A Firth, Stephen Green, Paul D Smith, Susan E Critchlow
Tumors frequently display a glycolytic phenotype with increased flux through glycolysis and concomitant synthesis of lactate. To maintain glycolytic flux and prevent intracellular acidification, tumors efflux lactate via lactate transporters (MCT1-4). Inhibitors of lactate transport have the potential to inhibit glycolysis and tumor growth. We developed a small molecule inhibitor of MCT1 (AZD3965) and assessed its activity across a panel of cell lines. We explored its antitumor activity as monotherapy and in combination with doxorubicin or rituximab...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050112/-clinical-pathologic-characteristics-and-treatment-outcomes-of-19-relapsed-pediatric-b-cell-lymphoma
#2
S Huang, L Jin, J Yang, Y L Duan, M Zhang, C J Zhou, X L Ma, Y H Zhang
Objective: To review the clinical-pathology characteristics of 19 relapsed pediatric mature B cell lymphoma and to find the risk factors for recurrence and the feasible treatment after relapse. Method: Data of 212 pediatric B cell lymphomas cases in Beijing Children's Hospital from January 2006 to June 2015 were collected retrospectively. All the patients were treated according to the B cell lymphoma regimen of Beijing Children's Hospital. During the study period, 19 of 212 cases were relapsed; the clinio-pathological characteristics of relapsed patients before treatment and after relapse were analyzed retrospectively, the treatment outcomes after relapse were summarized and the patients were followed-up...
October 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29047383/a-novel-small-molecule-inhibitor-of-p32-mitochondrial-protein-overexpressed-in-glioma
#3
Venkata Yenugonda, Natsuko Nomura, Valentina Kouznetsova, Igor Tsigelny, Valentina Fogal, Elmar Nurmemmedov, Santosh Kesari, Ivan Babic
BACKGROUND: The mitochondrial protein p32 is a validated therapeutic target of cancer overexpressed in glioma. Therapeutic targeting of p32 with monoclonal antibody or p32-binding LyP-1 tumor-homing peptide can limit tumor growth. However, these agents do not specifically target mitochondrial-localized p32 and would not readily cross the blood-brain barrier to target p32-overexpressing gliomas. Identifying small molecule inhibitors of p32 overexpressed in cancer is a more rational therapeutic strategy...
October 18, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29045918/cervical-cancer-cells-hela-response-to-photodynamic-therapy-using-a-zinc-phthalocyanine-photosensitizer
#4
Natasha Hodgkinson, Cherie Ann Kruger, Mpho Mokwena, Heidi Abrahamse
Cervical cancer is the most common gynecological malignancy worldwide, and the leading cause of cancer related deaths among females. Conventional treatment for early cervical cancer is radical hysterectomy. In locally advanced cancer the treatment of choice is concurrent chemo radiation. Although such treatment methods show promise, they do have adverse side effects. To minimize these effects, as well as prevent cancer re-occurrence, new treatment methods are being investigated. Photodynamic therapy (PDT) involves the selective uptake of a photosensitizer (PS) by cancer cells, illumination with light of an appropriate wavelength that triggers a photochemical reaction leading to the generation of reactive oxygen and subsequent tumor regression...
October 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29043013/mir-125a-suppresses-viability-and-glycolysis-and-induces-apoptosis-by-targeting-hexokinase-2-in-laryngeal-squamous-cell-carcinoma
#5
Zhanwei Sun, Wenqi Zhang, Qian Li
BACKGROUND: miR-125a usually functions as a tumor suppressor in cancers. However, the role of miR-125a in laryngeal squamous cell carcinoma (LSCC) has not been determined. METHODS: qRT-PCR was applied to measure the expression of miR-125a and HK2 mRNA in LSCC tissues and cells. CCK-8 kit and flow cytometry analysis were performed to detect cell viability and apoptosis. Luciferase reporter assay and RNA immunoprecipitation (RIP) were conducted to confirm the relationship between miR-125a and HK2...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29039526/promoting-effects-of-il%C3%A2-23-on-myocardial-ischemia-and-reperfusion-are-associated-with-increased-expression-of-il%C3%A2-17a-and-upregulation-of-the-jak2%C3%A2-stat3-signaling-pathway
#6
Yanxi Liao, Xiaorong Hu, Xin Guo, Bofang Zhang, Weipan Xu, Hong Jiang
Interleukin (IL)‑23, as a novel pro‑inflammatory cytokine, is important in several inflammatory diseases, including myocardial ischemia and reperfusion (I/R) injury, however, the underlying mechanism remains to be elucidated. The present study was designed to investigate the specific role of IL‑23 in myocardial I/R injury, and whether the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2‑STAT3) signaling pathway, one of the important downstream signaling pathways of IL‑23, and the IL‑17A downstream pro‑inflammatory cytokine, were involved...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29037410/heat-adaptation-from-regular-hot-water-immersion-decreases-proinflammatory-responses-hsp70-expression-and-physical-heat-stress
#7
Fwu-Lin Yang, Chia-Chi Lee, Yi-Maun Subeq, Chung-Jen Lee, Chun-Yen Ke, Ru-Ping Lee
Hot-water immersion (HWI) is a type of thermal therapy for treating various diseases. In our study, the physiological responses to occasional and regular HWI have been explored. The rats were divided into a control group, occasional group (1D), and regular group (7D). The 1D and 7D groups received 42°C during 15mins HWI for 1 and 7 days, respectively. The blood samples were collected for proinflammatory cytokines examinations, the heart, liver and kidney were excised for subsequent IHC analysis to measure the level of heat shock protein 70 (HSP70)...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29035503/comparison-between-short-and-long-echo-time-magnetic-resonance-spectroscopic-imaging-at-3t-and-7t-for-evaluating-brain-metabolites-in-patients-with-glioma
#8
Yan Li, Marisa Lafontaine, Susan Chang, Sarah J Nelson
Three-dimensional proton magnetic resonance spectroscopic imaging (MRSI) is a powerful non-invasive tool for characterizing spatial variations in metabolic profiles for patients with glioma. Metabolic parameters obtained using this technique have been shown to predict treatment response, disease progression, and transformation to a more malignant phenotype. The availability of ultra-high-field MR systems has the potential to improve the characterization of metabolites. The purpose of this study was to compare the metabolite profiles acquired with conventional long echo time (TE) MRSI at 3T with those obtained with short TE MRSI at 3T and 7T in patients with glioma...
October 16, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29033844/syngeneic-b16f10-melanoma-causes-cachexia-and-impaired-skeletal-muscle-strength-and-locomotor-activity-in-mice
#9
Fabrício A Voltarelli, Fernando T Frajacomo, Camila de Souza Padilha, Mayra T J Testa, Paola S Cella, Diogo F Ribeiro, Donizete X de Oliveira, Luciana C Veronez, Gabriela S Bisson, Felipe A Moura, Rafael Deminice
Muscle wasting has been emerging as one of the principal components of cancer cachexia, leading to progressive impairment of work capacity. Despite early stages melanomas rarely promotes weight loss, the appearance of metastatic and/or solid tumor melanoma can leads to cachexia development. Here, we investigated the B16F10 tumor-induced cachexia and its contribution to muscle strength and locomotor-like activity impairment. C57BL/6 mice were subcutaneously injected with 5 × 10(4) B16F10 melanoma cells or PBS as a Sham negative control...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29030348/lactate-fuels-the-tca-cycle-in-non-small-cell-lung-cancer
#10
(no author information available yet)
In many patients with NSCLC, lactate is a major fuel source for the tumor TCA cycle.
October 13, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29029484/ybx1-promotes-tumor-growth-by-elevating-glycolysis-in-human-bladder-cancer
#11
Liuyu Xu, Hongyun Li, Longchao Wu, Shiming Huang
Aerobic glycolysis, also known as Warburg effect, is a key hallmark of cancers. The Y-box-binding protein 1 (YBX1) is a well-known oncoprotein implicated in multiple malignant phenotypes of cancers. Meanwhile, little is known about the oncogenic functions and mechanisms of YBX1 in bladder cancer. Based on gene set enrichment analysis (GSEA) of TCGA RNAseq data, we find that YBX1 was profoundly involved in the glycolysis part of glucose metabolism. Loss- and gain-of-function studies show that YBX1 can enhance glycolysis as revealed by expression of glycolytic enzymes, glucose uptake, lactate secretion and extracellular acidification rate (ECAR)...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028110/melanoma-staging-evidence-based-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#12
Jeffrey E Gershenwald, Richard A Scolyer, Kenneth R Hess, Vernon K Sondak, Georgina V Long, Merrick I Ross, Alexander J Lazar, Mark B Faries, John M Kirkwood, Grant A McArthur, Lauren E Haydu, Alexander M M Eggermont, Keith T Flaherty, Charles M Balch, John F Thompson
Answer questions and earn CME/CNE To update the melanoma staging system of the American Joint Committee on Cancer (AJCC) a large database was assembled comprising >46,000 patients from 10 centers worldwide with stages I, II, and III melanoma diagnosed since 1998. Based on analyses of this new database, the existing seventh edition AJCC stage IV database, and contemporary clinical trial data, the AJCC Melanoma Expert Panel introduced several important changes to the Tumor, Nodes, Metastasis (TNM) classification and stage grouping criteria...
October 13, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29026299/glycogen-gold-nanohybrid-escalates-the-potency-of-silymarin
#13
Raghuram Kandimalla, Suvakanta Dash, Ashim Chandra Bhowal, Sanjeeb Kalita, Narayan Chandra Talukdar, Sarathi Kundu, Jibon Kotoky
In this study, a glycogen-gold nanohybrid was fabricated to enhance the potency of a promising hepatoprotective agent silymarin (Sly) by improving its solubility and gut permeation. By utilizing a facile green chemistry approach, biogenic gold nanoparticles were synthesized from Annona reticulata leaf phytoconstituents in combination with Sly (SGNPs). Further, the SGNPs were aggregated in glycogen biopolymer to yield the therapeutic nanohybrids (GSGNPs). Transmission electron microscopy, UV-Vis spectroscopy, X-ray diffraction, and Fourier transform infrared spectroscopy analysis confirmed the successful formation and conjugation of both SGNPs and GSGNPs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29018777/rationale-feasibility-and-acceptability-of-ketogenic-diet-for-cancer-treatment
#14
REVIEW
Hae-Yun Chung, Yoo Kyoung Park
Ketogenic diet has been used for more than 80 years as a successful dietary regimen for epilepsy. Recently, dietary modulation by carbohydrate depletion via ketogenic diet has been suggested as an important therapeutic strategy to selectively kill cancer cells and as adjuvant therapy for cancer treatment. However, some researchers insist ketogenic diet to be highly undesirable as ketogenic diet may trigger and/or exacerbate cachexia development and usually result in significant weight loss. This review revisits the meaning of physiological ketosis in the light of this evidence and considers possibility of the use of ketogenic diet for oncology patients...
September 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29016888/metabolic-heterogeneity-and-plasticity-of-glioma-stem-cells-in-a-mouse-glioblastoma-model
#15
Shunsuke Shibao, Noriaki Minami, Naoyoshi Koike, Nobuyuki Fukui, Kazunari Yoshida, Hideyuki Saya, Oltea Sampetrean
Background: Glioblastomas have been shown to rely on glycolysis as an energy source. However, recent evidence suggests that at least a subset of glioma cells with stem cell-like properties can thrive on oxidative phosphorylation. It remains unclear whether both metabolic phenotypes support tumor propagation, if they are independent, and how stable they are. The present study investigated these questions with the use of isogenic murine glioma stem cells (GSCs). Methods: GSCs were established from tumors formed by Ink4a/Arf-null, H-RasV12-expressing glioma-initiating cells that differed in extracellular acidification potential...
September 2, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28985743/efficacy-of-functional-foods-mixture-in-improving-hypercholesterolemia-inflammatory-and-endothelial-dysfunction-biomarkers-induced-by-high-cholesterol-diet
#16
Hessah Mohammed Al-Muzafar, Kamal Adel Amin
BACKGROUND: Hypercholesterolemia associated with cardiovascular diseases is a global health issue that could be alleviated by functional foods. This study aimed to explore the effects of a high-cholesterol diet on lipid profile, cardiac, inflammatory, and endothelial dysfunction biomarkers, and the possible improvement by functional foods mixture. METHODS: Male albino rats weighing 100-150 g were randomly divided into four equal groups: 1st control, giving a normal diet; the 2nd received high-cholesterol diet for 8 weeks, the 3rd received the high-cholesterol diet + functional foods mixture, and the 4th administered high-cholesterol diet +atorvastatin (20 mg) orally...
October 6, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28985563/lactate-metabolism-in-human-lung-tumors
#17
Brandon Faubert, Kevin Y Li, Ling Cai, Christopher T Hensley, Jiyeon Kim, Lauren G Zacharias, Chendong Yang, Quyen N Do, Sarah Doucette, Daniel Burguete, Hong Li, Giselle Huet, Qing Yuan, Trevor Wigal, Yasmeen Butt, Min Ni, Jose Torrealba, Dwight Oliver, Robert E Lenkinski, Craig R Malloy, Jason W Wachsmann, Jamey D Young, Kemp Kernstine, Ralph J DeBerardinis
Cancer cells consume glucose and secrete lactate in culture. It is unknown whether lactate contributes to energy metabolism in living tumors. We previously reported that human non-small-cell lung cancers (NSCLCs) oxidize glucose in the tricarboxylic acid (TCA) cycle. Here, we show that lactate is also a TCA cycle carbon source for NSCLC. In human NSCLC, evidence of lactate utilization was most apparent in tumors with high (18)fluorodeoxyglucose uptake and aggressive oncological behavior. Infusing human NSCLC patients with (13)C-lactate revealed extensive labeling of TCA cycle metabolites...
October 5, 2017: Cell
https://www.readbyqxmd.com/read/28983605/ldha-promotes-tumor-metastasis-by-facilitating-epithelial%C3%A2-mesenchymal-transition-in-renal-cell-carcinoma
#18
Juping Zhao, Xin Huang, Zhaoping Xu, Jun Dai, Hongchao He, Yu Zhu, Haofei Wang
Previous studies have indicated that high expression of lactate dehydrogenase A (LDHA) exists in many human cancers. Recently, several reports showed that silencing or inhibition of LDHA could suppress metastasis of human cancer including renal cell carcinoma (RCC). However, the mechanism remains unknown. The role of LDHA in RCC migration and invasion was investigated using immunohistochemistry, western blotting, Transwell and scratch assays, and in vivo experiment. The influence of LDHA on the Warburg effect was also investigated by LDHA activity and lactate production assay...
September 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28982326/synthesis-of-cinnamyl-and-caffeoyl-derivatives-of-cucurbitacin-e-glycoside-isolated-from-citrullus-colocynthis-fruits-and-their-structure-antioxidant-and-anti-inflammatory-activities-relationship
#19
Mohammed Abdalla Hussein, Heba Abd-Elhady El-Gizawy, Naglaa Abd El Khalik Gobba, Yasser Omar Mosaad
BACKGROUND: Citrullus colocynthis (Linn.) Schrad. is an important medicinal plant belonging to family Cucurbitaceae. Cucurbitacin E glucoside (1) was isolated from Citrullus colocynthis fruits. A novel mono-ester of cucurbitacin-E and cinnamyl & caffeoyl-β- D- glucoside (2 and 3) were synthesized by reacting of cucurbitacin E glucoside with cinnamic and/or caffeic acid in presence of CHCl2 and K2CO3 stirring and with an ice-cooling state for 24h. Mass analyses of the isolated and purified compounds were determined...
October 4, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28979900/comparison-of-the-effects-of-interleukin-1-on-equine-articular-cartilage-explants-and-cocultures-of-osteochondral-and-synovial-explants
#20
Christopher R Byron, Richard A Trahan
Osteoarthritis (OA) is a ubiquitous disease affecting many horses. The disease causes chronic pain and decreased performance for patients and great cost to owners for diagnosis and treatment. The most common treatments include systemic non-steroidal anti-inflammatory drugs and intra-articular injection of corticosteroids. There is excellent support for the palliative pain relief these treatments provide; however, they do not arrest progression and may in some instances hasten advancement of disease. Orthobiologic treatments have been investigated as potential OA treatments that may not only ameliorate pain but also prevent or reverse pathologic articular tissue changes...
2017: Frontiers in Veterinary Science
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