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Jennifer Chang, Keerthi Arani, Sheena Chew, Matthew P Frosch, R Gilberto Gonzalez, Noor Maza, Javier M Romero
BACKGROUND: We detected a novel imaging sign, which consists of a specific imaging pattern of diffuse susceptibility effect, delineating the cortical-subcortical junction on high-resolution susceptibility-weighted images (SWIs). We describe magnetic resonance imaging findings in 10 patients with "susceptibility etching" and possible association with their abnormal coagulation profile. MATERIALS/METHODS: A retrospective case series study with a search for cases that demonstrated susceptibility effect at the cortical-subcortical junction on SWI sequences was performed...
August 19, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Uwe Wollina, Dana Langner, Birgit Heinig, Andreas Nowak
BACKGROUND: Acne inversa (hidradentitis suppurativa; AI) is a severe chronic relapsing inflammatory skin disease of unknown cause. Anogenital AI has the strongest negative impact on quality of life and causes great disability. OBJECTIVES: We analyzed patients, comorbities, outcome of extensive surgery, and possible adverse effects. PATIENTS AND METHODS: We included patients from January 2000 to March 2015 with anogenital AI Hurley grade III...
August 6, 2016: International Journal of Dermatology
Cristóbal Esteban, Susana Garcia-Gutierrez, Maria J Legarreta, Ane Anton-Ladislao, Nerea Gonzalez, Iratxe Lafuente, Nerea Fernandez de Larrea, Silvia Vidal, Marisa Bare, José M Quintana, Iryss -Copd Group
Mortality is one of the most important outcomes in patients with chronic obstructive pulmonary disease (COPD). Different predictors have been associated with mortality, including the patient's level of physical activity (PA). The objective of this work was to establish the relationship between changes in PA during a moderate-to-severe COPD exacerbation (eCOPD) and 1-year mortality after the index event. This was a prospective observational cohort study with recruitment of 2,484 patients with an eCOPD attending the emergency department (ED) of 16 participating hospitals...
June 10, 2016: COPD
Gregory A Joice, Phillip M Pierorazio, Mohamad E Allaf
PURPOSE OF REVIEW: The purpose is to discuss current data on the utilization and outcomes of active surveillance for T1a renal masses. Specifically, to address which patients are optimal for active surveillance and how their outcomes differ from those undergoing immediate treatment. RECENT FINDINGS: Although nephron sparing surgery is the standard of care for small renal masses (SRMs), active surveillance is becoming a more popular intervention given the results of prospective studies revealing active surveillance to be safe and have excellent cancer-specific survival with intermediate follow-up...
September 2016: Current Opinion in Urology
W Stuart Reynolds, Roger Dmochowski, Alan Wein, Stephen Bruehl
The pathophysiological mechanisms underlying overactive bladder syndrome (OAB) can include dysfunction of sensory pathways of the peripheral and central nervous systems, resulting in bladder hypersensitivity. Central sensitization describes an induced state of spinal hypersensitivity that is associated with a variety of chronic pain disorders that share many attributes with OAB, albeit without the presence of pain. As such, the concept of central sensitization might be relevant to understanding the mechanisms and clinical manifestations of OAB syndrome...
August 2016: Nature Reviews. Urology
Sanjeev Sockalingam, Ahmad Alzahrani, Christopher Meaney, Rima Styra, Adrienne Tan, Raed Hawa, Susan E Abbey
OBJECTIVES: The aim of this study was to determine the relationship between the time to referral (TTR) to psychiatric consultation and the length of stay (LOS) after adjusting for medical comorbity. METHODS: Using a naturalistic study design, we collected and analyzed inpatient consultation-liaison psychiatry service data over a 12-month period from 2 Canadian hospital sites. Data collected included demographic characteristics, referral characteristics, Charlson Comorbidity Index to measure medical comorbidity severity, psychiatric diagnoses, type of psychiatric intervention, and time variables, namely TTR and LOS...
May 2016: Psychosomatics
Arianna Waye, Kerry Atkins, Dina Kao
BACKGROUND: Fecal microbiota transplantation (FMT) is highly effective in treating recurrent Clostridium difficile infection (RCDI). However, the ideal timing for offering FMT remains to be determined. Furthermore, the direct medical costs averted with timely FMT have not been examined. METHODS: A retrospective review of the Edmonton FMT program database included patients who received FMT for RCDI (October 2012 to September 2014). They were divided into 2 groups: those who received FMT after 2 recurrences (the timely FMT group) and those who received FMT after at least 3 recurrences (the delayed FMT group)...
October 2016: Journal of Clinical Gastroenterology
Reena Sherin, Padmaja Udaykumar
BACKGROUND: Associated co-morbidities with psoriasis are treated with concomitant medications apart from the antipsoriatic therapy and the resulting Drug-Drug Interactions (DDI) may affect therapeutic outcome. OBJECTIVE: To assess the DDI in psoriatic patients with co-morbidities. METHOD: In this prospective observational analysis, 150 prescriptions of psoriatic patients, receiving two or more drugs were analysed using drug interaction checker software...
2016: Reviews on Recent Clinical Trials
Devon Beebe Palumbo, Kathleen Joos, Dirk De Ridder, Sven Vanneste
Tinnitus, a phantom sensation experienced by people around the world, currently is endured without a known cure. Some find the condition tolerable, while others are tortured on a daily basis from the incessant phantom noises. For those who seek treatment, oftentimes, they have a comorbid condition (e.g., depression, anxiety, insomnia), which is treated pharmaceutically. These products aim to reduce the comorbities associated with tinnitus thereby minimizing the overall burden present. Because of the phantom nature of tinnitus, it is often compared to neurologic pain...
2015: Current Neuropharmacology
Guy C Jones, Jason D Kehrer, Jenna Kahn, Bobby N Koneru, Ram Narayan, Tarita O Thomas, Kevin Camphausen, Minesh P Mehta, Aradhana Kaushal
Lung cancer is among the most common cancers worldwide and is the leading cause of cancer death in both men and women. For patients with early stage (American Joint Committee on Cancer T1-2, N0) non-small-cell lung cancer, the current standard of care is lobectomy with systematic lymph node evaluation. Unfortunately, patients with lung cancer often have medical comorbities, which may preclude the option of surgical resection. In such cases, a number of minimally invasive to noninvasive treatment options have gained popularity in the treatment of these high-risk patients...
November 2015: Clinical Lung Cancer
Filipe S Cardoso, Sean M Bagshaw, Juan G Abraldes, Norman M Kneteman, Glenda Meeberg, Pedro Fidalgo, Constantine J Karvellas
BACKGROUND: Improving estimation of long-term survival of patients with end-stage liver disease after orthotopic liver transplantation (OLT) would optimize decisions on eligibility for transplant. We aimed to externally validate previously derived Charlson Comorbity Index for OLT (CCI-OLT); subsequently, we developed a new model to predict 5-year mortality after transplant. MATERIAL AND METHODS: This single center retrospective cohort study included 524 consecutive adult cirrhotic patients who underwent OLT in 2002-2012...
July 2015: Annals of Hepatology
Ingo Schmidt
Thumb carpometacarpal joint osteoarthritis is the most common site of non-rheumatic degenerative lesion in the hand, and there are special features in rheumatic patients. None of various surgical treatment options can be declared as "gold standard" recently. The surgical treatment depends on patient's age, patient's claims in work and leisure, local bone stock, possible allergies, local comorbities, and local deformities.
May 21, 2015: Current Rheumatology Reviews
Janaina Menezes Zanoveli, Helen de Morais, Isabella Caroline da Silva Dias, Anne Karoline Schreiber, Camila Pasquini de Souza, Joice Maria da Cunha
Diabetes is a chronic and progressive syndrome commonly associated with several neuropsychiatric comorbities, of which depression is the most studied. The prevalence of depression is about two or three times higher in diabetic patients compared to the general population. It is believed that the diabetes - depression relation may be bidirectional, i.e., the depression can lead to diabetes and conversely diabetes could facilitate the emergence of depression. Depression is one of the most neglected symptoms in diabetic patients and is directly linked with lowering of quality of life...
2016: Current Diabetes Reviews
David Rowell, Louisa G Gordon, Catherine M Olsen, David C Whiteman
The medical record is a repository of clinical data, which can greatly enhance the quality of health and healthcare analysis. Administrative data are collected for the purpose of billing and reimbursement, and are valued by health researchers because the data are routinely audited to maintain accurate financial records. However, the quantity of incorporated clinical data can be variable. In this paper we reconstruct the medical record from health service invoices to estimate the cost of treating keratinocytic cancer (KC)...
2015: Health Economics Review
Nicolas Schaad, Arnaud Perrier
No abstract text is available yet for this article.
January 28, 2015: Revue Médicale Suisse
Ashima A Lal, Amy A Case
Chronic obstructive pulmonary disease (COPD) is associated with a progressive course with a variable illness trajectory causing death either from respiratory failure or complications from its comorbities. Palliative care benefits patients throughout all stages of COPD, with a goal to manage patients' symptom burden which can reduce physical, psychological, and social complications. Dyspnea is the most common and distressing symptom patients with end stage COPD experience, which responds only partially to therapy and eventually becomes refractory to routine care...
October 2014: Annals of Palliative Medicine
Helen Court, Gary McLean, Bruce Guthrie, Stewart W Mercer, Daniel J Smith
BACKGROUND: Visual impairment is common in older people and the presence of additional health conditions can compromise health and rehabilitation outcomes. A small number of studies have suggested that comorbities are common in visual impairment; however, those studies have relied on self-report and have assessed a relatively limited number of comorbid conditions. METHODS: We conducted a cross-sectional analysis of a dataset of 291,169 registered patients (65-years-old and over) within 314 primary care practices in Scotland, UK...
2014: BMC Medicine
Matthew H Beristianos, Kristine Yaffe, Beth Cohen, Amy L Byers
OBJECTIVES: To determine if late-life posttraumatic stress disorder (PTSD) is associated with cardiovascular disease in a sample of older veterans, and whether the association is independent of medical and psychiatric comorbities. DESIGN: Retrospective cohort study conducted using the Department of Veterans Affairs (VA) National Patient Care Database (2000-2011). SETTING: VA medical centers in the United States. PARTICIPANTS: A total of 138,341 veterans 55 years and older without cardiovascular disease at study baseline (2000-2003)...
March 2016: American Journal of Geriatric Psychiatry
Dijon Henrique Salomé de Campos, André Soares Leopoldo, Ana Paula Lima-Leopoldo, André Ferreira do Nascimento, Silvio Assis de Oliveira-Junior, Danielle Cristina Tomaz da Silva, Mario Mateus Sugizaki, Carlos Roberto Padovani, Antonio Carlos Cicogna
BACKGROUND: Obesity is defined by excessive accumulation of body fat relative to lean tissue. Studies during the last few years indicate that cardiac function in obese animals may be preserved, increased or diminished. OBJECTIVE: Study the energy balance of the myocardium with the hypothesis that the increase in fatty acid oxidation and reduced glucose leads to cardiac dysfunction in obesity. METHODS: 30-day-old male Wistar rats were fed standard and hypercaloric diet for 30 weeks...
October 2014: Arquivos Brasileiros de Cardiologia
C L Teh, K F Chew, G R Ling
we performed a prospective study of all hospitalized patients with a diagnosis of Gout in Sarawak General hospital from 1st July 2011 to 1st July 2012. There were a total of 126 patients in our study of which 112 (88.9%) were males. The majority of our patients were from the indigenous populations (71.7%). They have a mean age of 60.0 ± 14.2 years. Most of our patients were overweight (68%) with comorbities of hypertension (78.6%), Chronic Kidney Failure (48.4%), Type II diabetes Mellitus (30.2%), dyslipidemia (27...
June 2014: Medical Journal of Malaysia
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