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Parkinson's executive function

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https://www.readbyqxmd.com/read/29780572/cognitive-training-and-transcranial-direct-current-stimulation-for-mild-cognitive-impairment-in-parkinson-s-disease-a-randomized-controlled-trial
#1
Blake J Lawrence, Natalie Gasson, Andrew R Johnson, Leon Booth, Andrea M Loftus
This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cognitive impairment (PD-MCI). Forty-two participants with PD-MCI were randomized to one of six groups: (1) standard cognitive training, (2) tailored cognitive training, (3) tDCS, (4) standard cognitive training + tDCS, (5) tailored cognitive training + tDCS, or (6) a control group...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29756356/neuroimaging-abnormalities-in-individuals-exhibiting-parkinson-s-disease-risk-markers
#2
Marcus Heldmann, Janna Heeren, Christine Klein, Linus Rauch, Johann Hagenah, Thomas F Münte, Meike Kasten, Norbert Brüggemann
BACKGROUND: The concept of prodromal Parkinson's disease (PD) involves variable combinations of nonmotor features and subtle motor abnormalities as a result of ongoing neurodegeneration in the brain stem including substantia nigra (SN) and abnormal findings upon transcranial sonography and nuclear imaging. Except for nuclear imaging, the predictive value of risk markers for the conversion to overt PD is low. OBJECTIVE: The objective of this study was to determine whether PD risk markers are associated with changes in brain structure and to what extent cognitive changes are risk markers for PD...
May 14, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29751598/informed-consent-decision-making-in-deep-brain-stimulation
#3
REVIEW
Gabriele Mandarelli, Germana Moretti, Massimo Pasquini, Giuseppe Nicolò, Stefano Ferracuti
Deep brain stimulation (DBS) has proved useful for several movement disorders (Parkinson’s disease, essential tremor, dystonia), in which first and/or second line pharmacological treatments were inefficacious. Initial evidence of DBS efficacy exists for refractory obsessive-compulsive disorder, treatment-resistant major depressive disorder, and impulse control disorders. Ethical concerns have been raised about the use of an invasive surgical approach involving the central nervous system in patients with possible impairment in cognitive functioning and decision-making capacity...
May 11, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29747716/effects-of-antiparkinson-medication-on-cognition-in-parkinson-s-disease-a-systematic-review
#4
Marc-André Roy, Maxime Doiron, Jessica Talon-Croteau, Nicolas Dupré, Martine Simard
OBJECTIVE: This study aimed to systematically review the effects of currently prescribed antiparkinson medication on cognition in patients with mild-to-moderate Parkinson's disease (PD) who were either cognitively intact or mildly impaired. METHODS: English- and French-language studies published between 1969 and 2017 were accessed via MedLine, PsychNET, EMBASE and EBSCO databases. Methodological quality (MQ) was evaluated with the quality assessment instrument of the Cochrane Collaboration Depression, Anxiety and Neurosis Review (scores from 0% to 44% indicate very low quality; scores from 45% to 64% indicate low quality; scores from 65% to 84% indicate medium quality; and scores from 85% to 100% indicate high quality)...
May 11, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29738912/functionally-separated-networks-for-self-paced-and-externally-cued-motor-execution-in-parkinson-s-disease-evidence-from-deep-brain-recordings-in-humans
#5
Oliver Bichsel, Roger Gassert, Lennart Stieglitz, Mechthild Uhl, Heide Baumann-Vogel, Daniel Waldvogel, Christian R Baumann, Lukas L Imbach
Spatially segregated cortico-basal ganglia networks have been proposed for the control of goal-directed and habitual behavior. In Parkinson's disease, selective loss of dopaminergic neurons regulating sensorimotor (habitual) behavior might therefore predominantly cause deficits in habitual motor control, whereas control of goal-directed movement is relatively preserved. Following this hypothesis, we examined the electrophysiology of cortico-basal ganglia networks in Parkinson patients emulating habitual and goal-directed motor control during self-paced and externally-cued finger tapping, respectively, while simultaneously recording local field potentials in the subthalamic nucleus (STN) and surface EEG...
May 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29706433/cognitive-correlates-of-pure-apathy-in-parkinson-s-disease
#6
Gabriella Santangelo, Alfonsina D'Iorio, Gianpaolo Maggi, Sofia Cuoco, Maria Teresa Pellecchia, Marianna Amboni, Paolo Barone, Carmine Vitale
INTRODUCTION: Previous studies exploring the association between apathy and cognitive deficits in Parkinson's disease (PD) employed scales and questionnaires for apathy, which did not control for the possible confounding effect of motor symptoms. Here we investigated the cognitive correlates of "pure apathy" by the Dimensional Apathy Scale, which allows us to assess apathy minimizing the influence of motor symptoms. METHODS: Consecutive PD outpatients referred to our centre were screened...
April 24, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29696615/influence-of-cognitive-impairment-on-the-freezing-of-gait-in-non-demented-people-with-parkinson-s-disease
#7
J M Cancela, C M Nascimento, S Varela, M Seijo-Martinez, L Lorenzo-Lopez, J C Millan-Calenti, C Dominguez-Vivero, C Ayan
INTRODUCTION: Freezing of gait (FOG) is a motor disturbance usually appearing in advanced Parkinson's disease (PD). Cognitive and executive function seems to play an important role in this phenomenon. AIM: To investigate if cognitive and kinematic parameters correlate with FOG in PD patients without dementia. PATIENTS AND METHODS: We conducted an observational cross-sectional study. Participants were classified in two groups: freezers and non-freezers...
May 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29696499/longitudinal-diffusion-tensor-imaging-changes-in-early-parkinson-s-disease-icicle-pd-study
#8
Thais Minett, Li Su, Elijah Mak, Guy Williams, Michael Firbank, Rachael A Lawson, Alison J Yarnall, Gordon W Duncan, Adrian M Owen, Tien K Khoo, David J Brooks, James B Rowe, Roger A Barker, David Burn, John T O'Brien
OBJECTIVE: To investigate whether white matter microstructural changes can be used as a predictor of worsening of motor features or cognitive decline in patients with Parkinson's disease and verify whether white matter microstructural longitudinal changes differ between patients with Parkinson's disease with normal cognition and those with mild cognitive impairment. METHODS: We enrolled 120 newly diagnosed patients with early stage Parkinson's disease (27 with mild cognitive impairment and 93 with normal cognition) along with 48 controls...
April 25, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29690546/a-rationale-for-music-training-to-enhance-executive-functions-in-parkinson-s-disease-an-overview-of-the-problem
#9
Teresa Lesiuk, Jennifer A Bugos, Brea Murakami
Music listening interventions such as Rhythmic Auditory Stimulation can improve mobility, balance, and gait in Parkinson’s Disease (PD). Yet, the impact of music training on executive functions is not yet known. Deficits in executive functions (e.g., attention, processing speed) in patients with PD result in gait interference, deficits in emotional processing, loss of functional capacity (e.g., intellectual activity, social participation), and reduced quality of life. The model of temporal prediction and timing suggests two networks collectively contribute to movement generation and execution: the basal ganglia-thalamocortical network (BGTC) and the cerebellar-thalamocortical network (CTC)...
April 22, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29683777/relationship-between-posturography-clinical-balance-and-executive-function-in-parkinson%C3%A2-s-disease
#10
Carolina de Oliveira Souza, Mariana Callil Voos, Alessandra Ferreira Barbosa, Janini Chen, Debora Cristina Valente Francato, Matija Milosevic, Milos Popovic, Erich Talamoni Fonoff, Hsin Fen Chien, Egberto Reis Barbosa
This study aimed to evaluate the relationship between posturography, clinical balance, and executive function tests in Parkinson´s disease (PD). Seventy-one people participated in the study. Static posturography evaluated the center of pressure fluctuations in quiet standing and dynamic posturography assessed sit-to-stand, tandem walk, and step over an obstacle. Functional balance was evaluated by Berg Balance Scale, MiniBESTest, and Timed Up and Go test. Executive function was assessed by Trail Making Test (TMT) and semantic verbal fluency test...
April 23, 2018: Journal of Motor Behavior
https://www.readbyqxmd.com/read/29682233/personality-factors-and-cognitive-functioning-in-elderly-with-parkinson-s-disease
#11
Neusa Maria de Oliveira Chardosim, Camila Rosa Oliveira, Manuela Polidoro Lima, Marianne Farina, Valéria Gonzatti, Dalton Breno Costa, Aline Sória Pereira, Luis Henrique Paloski, Tatiana Quarti Irigaray, Irani Iracema de Lima Argimon
Parkinson's disease (PD) is a chronic and progressive neurological disease, resulting from cell degeneration in the substantia nigra, responsible for the production of dopamine. Objective: This study aimed to characterize the cognitive functioning, personality factors and prevalence of depressive and anxiety symptoms in individuals with Parkinson's disease (PD). Furthermore, this study sought to analyze whether personality factors were predictors of cognitive functioning. Methods: The sample consisted of 30 elderly with PD...
January 2018: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29680151/vmat2-inhibitors-and-the-path-to-ingrezza-valbenazine
#12
Nicole D Harriott, John P Williams, Evan B Smith, Haig P Bozigian, Dimitri E Grigoriadis
The dopaminergic system plays a key role in the central nervous system, regulating executive function, arousal, reward, and motor control. Dysregulation of this critical monoaminergic system has been associated with diseases of the central nervous system including schizophrenia, Parkinson's disease, and disorders such as attention deficit hyperactivity disorders and addiction. Drugs that modify the dopaminergic system by modulating the activity of dopamine have been successful in demonstrating clinical efficacy by providing treatments for these diseases...
2018: Progress in Medicinal Chemistry
https://www.readbyqxmd.com/read/29678775/involvement-of-gap-junctions-in-astrocyte-impairment-induced-by-manganese-exposure
#13
Cailing Lu, Zhijuan Meng, Yiyuan He, Deqiang Xiao, Haiqing Cai, Yilu Xu, Xianghong Liu, Xinhang Wang, Laiming Mo, Ziwei Liang, Xuejing Wei, Qingqing Ao, Boying Liang, Xiyi Li, Shen Tang, Songchao Guo
Glutamate excitotoxicity, characterized as excessive glutamate stress, is considered to be involved in cerebral ischaemia, brain trauma, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Glutamate homeostasis disruption was highlighted in Mn neurotoxicity caused by high levels of Mn. Astrocytes, accounting for approximately 50% of the neuronal cells in the central nervous system and maintain glutamate homeostasis, are sensitive to neurotoxicity induced by Mn exposure. Astrocytes are tightly coupled with gap junctions (GJ), which are comprised of connexins, mainly connexin43 (Cx43)...
April 17, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29675956/clonidine-modulates-the-activity-of-the-subthalamic-supplementary-motor-loop-evidence-from-a-pharmacological-study-combining-dbs-and-eeg-recordings-in-parkinsonian-patients
#14
Charlotte Spay, Marion Albares, Guillaume Lio, Stephane Thobois, Emmanuel Broussolle, Brian Lau, Benedicte Ballanger, Philippe Boulinguez
Clonidine is an anti-hypertensive medication which acts as an alpha-adrenergic receptors agonist. As the noradrenergic system is likely to support cognitive functions including attention and executive control, other clinical uses of clonidine have recently gained popularity for the treatment of neuropsychiatric disorders like attention-deficit hyperactivity disorder or Tourette syndrome, but the mechanism of action is still unclear. Here, we test the hypothesis that the noradrenergic system regulates the activity of subthalamo-motor cortical loops, and that this influence can be modulated by clonidine...
April 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29665124/how-does-dementia-with-lewy-bodies-start-prodromal-cognitive-changes-in-rem-sleep-behavior-disorder
#15
Daphné Génier Marchand, Ronald B Postuma, Frédérique Escudier, Jessie De Roy, Amélie Pelletier, Jacques Montplaisir, Jean-François Gagnon
Objective We describe the progression of cognitive decline and identify the predictive values of cognitive tests in three groups of REM sleep behavior disorder (RBD) patients classified at their last follow-up as having Parkinson's disease (PD), dementia with Lewy bodies (DLB), or still-idiopathic. Methods Patients (n=109) underwent polysomnographic, neurological, and neuropsychological assessments. We used linear mixed-model analyses to compare the progression of cognitive test performance between the three groups over a three-year prodromal period, and performed linear regressions for a six-year prodromal period...
April 17, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29664048/effect-of-rapid-eye-movement-sleep-behavior-disorder-on-obstructive-sleep-apnea-severity-and-cognition-of-parkinson-s-disease-patients
#16
Jun-Ying Huang, Jin-Ru Zhang, Yun Shen, Hui-Jun Zhang, Yu-Lan Cao, Cheng-Jie Mao, Ya-Ping Yang, Jing Chen, Chun-Feng Liu, Jie Li
Background: Rapid eye movement (REM) sleep behavior disorder (RBD) and obstructive sleep apnea (OSA) are the most common sleep disorders in Parkinson's disease (PD). The aim of this study was to identify whether RBD could alleviate OSA severity in PD patients and its effect on cognitive impairment. Methods: From February 2014 to May 2017, we recruited 174 PD patients from the Second Affiliated Hospital of Soochow University, all of whom underwent polysomnography (PSG)...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29627942/orthostatic-hypotension-acutely-impairs-executive-functions-in-parkinson-s-disease
#17
Michela Sforza, Francesca Assogna, Domiziana Rinaldi, Giuliano Sette, Stefania Tagliente, Francesco E Pontieri
Orthostatic hypotension is a frequent non-motor symptom of Parkinson's disease, with negative prognostic role on cognitive functions. Here we measured the acute effects of orthostatic hypotension on executive functions in Parkinson's disease patients devoid of hypertension, carotid artery stenosis, and significant chronic cerebrovascular pathology. Measurements were carried out during regular visits in outpatient setting. Twenty-eight Parkinson's disease patients were recruited and studied along scheduled outpatient visits...
April 7, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29614698/cognitive-rehabilitation-in-parkinson-s-disease-a-systematic-review
#18
Hamad Alzahrani, Annalena Venneri
BACKGROUND: Cognitive impairments are the most common non-motor symptoms in Parkinson's disease (PD). These symptoms have a negative impact on patients' quality of life and daily living activities. This review will focus on published articles that investigated the efficacy of cognitive rehabilitation in PD. OBJECTIVES: To review the existing literature on the efficacy of cognitive rehabilitation in PD and highlight the most effective form of intervention to prevent cognitive decline...
March 26, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29610105/cortical-thinning-and-cognitive-impairment-in-parkinson-s-disease-without-dementia
#19
Lijun Zhang, Ming Wang, Nicholas W Sterling, Eun-Young Lee, Paul J Eslinger, Daymond Wagner, Guangwei Du, Mechelle M Lewis, Young Truong, F DuBois Bowman, Xuemei Huang
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized clinically by motor dysfunction (bradykinesia, rigidity, tremor, and postural instability), and pathologically by the loss of dopaminergic neurons in the substantia nigra of the basal ganglia. Growing literature supports that cognitive deficits may also be present in PD, even in non-demented patients. Gray matter (GM) atrophy has been reported in PD and may be related to cognitive decline. This study investigated cortical thickness in non-demented PD subjects and elucidated its relationship to cognitive impairment using high-resolution T1-weighted brain MRI and comprehensive cognitive function scores from 71 non-demented PD and 48 control subjects matched for age, gender, and education...
March 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/29608880/limitations-of-the-rat-medial-forebrain-lesion-model-to-study-prefrontal-cortex-mediated-cognitive-tasks-in-parkinson-s-disease
#20
Courtney Marshall, Kirsten M King, Sandhya Kortagere
Parkinson's Disease (PD) is a progressive movement disorder characterized by the loss of dopaminergic neurons in the midbrain. Besides motor impairment, PD patients exhibit non-motor symptoms that negatively impact their quality of life and often manifest prior to motor deficits. One such symptom is mild cognitive impairment (PD-MCI), which is comprised of deficits in executive function such as working memory, attention, cognitive flexibility, and spatial memory. The 6-hydroxydopamine (6-OHDA) induced unilateral medial forebrain bundle (MFB) lesion animal model successfully recapitulates PD motor impairment but is also used to assess non-motor deficits...
March 30, 2018: Brain Research
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