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Parkinson's executive function

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https://www.readbyqxmd.com/read/29124784/dysfunction-in-emotion-processing-underlies-functional-psychogenic-dystonia
#1
Alberto J Espay, Thomas Maloney, Jennifer Vannest, Matthew M Norris, James C Eliassen, Erin Neefus, Jane B Allendorfer, Robert Chen, Jerzy P Szaflarski
OBJECTIVE: We sought to determine whether abnormalities in emotion processing underlie functional (psychogenic) dystonia, one of the most common functional movement disorders. METHODS: Motor and emotion circuits were examined in 12 participants with functional dystonia, 12 with primary organic dystonia, and 25 healthy controls using functional magnetic resonance imaging at 4T and a finger-tapping task (motor task), a basic emotion-recognition task (emotional faces task), and an intense-emotion stimuli task...
November 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29123404/effects-of-dopaminergic-drug-adjustment-on-executive-function-in-different-clinical-stages-of-parkinson-s-disease
#2
Hidetomo Murakami, Tetsuhito Nohara, Hidenobu Shozawa, Yoshiyuki Owan, Takeshi Kuroda, Satoshi Yano, Machiko Kezuka, Mitsuru Kawamura, Kenjiro Ono
Background: Effects of dopaminergic medication on executive function in patients with Parkinson's disease (PD) are inconsistent. Objective: We examined the effect of dopaminergic medication on executive function in 24 drug-naïve PD patients (de novo group) and in 21 PD patients on chronic dopaminergic medication (chronic medication group). Methods: PD patients without dementia were included in this study. For the de novo group patients, dopaminergic medication was initiated, and the dose was increased to improve motor symptoms...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29120562/be-vigilant-for-dementia-in-parkinson%C3%A2-s-disease
#3
Flavia Niccolini, Konstantinos Diamantopoulos, Stelios Kiosses, Marios Politis
It is estimated that up to 80% of patients with Parkinson's disease will eventually develop cognitive impairment over the course of their illness. Even at the time of diagnosis, cognitive impairment has been reported in 20-25% of patients. Commonly affected cognitive domains are executive function, visuospatial ability and attention control. In addition, patients with Parkinson's disease dementia may present with deficits in language function and verbal memory. Psychosis may occur in approximately 40% of patients with Parkinson's disease, and is associated with an increased risk of developing cognitive impairment...
May 2017: Practitioner
https://www.readbyqxmd.com/read/29094067/comorbidities-confounding-the-outcomes-of-surgery-for-third-window-syndrome-outlier-analysis
#4
P Ashley Wackym, Heather T Mackay-Promitas, Shaban Demirel, Gerard J Gianoli, Martin S Gizzi, Dale M Carter, David A Siker
Objective: Patients with third window syndrome and superior semicircular canal dehiscence (SSCD) symptoms whose surgical outcomes placed them as outliers were systematically studied to determine comorbidities that were responsible for their poor outcomes due to these confounding factors. Study Design: Observational analytic case-control study in a tertiary referral center. Methods: Twelve adult patients with clinical SSCD syndrome underwent surgical management and had outcomes that did not resolve all of their subjective symptoms...
October 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29082658/cognitive-impairment-in-progressive-supranuclear-palsy-is-associated-with-tau-burden
#5
Shunsuke Koga, Adam Parks, Koji Kasanuki, Monica Sanchez-Contreras, Matthew C Baker, Keith A Josephs, J Eric Ahlskog, Ryan J Uitti, Neill Graff-Radford, Jay A van Gerpen, Zbigniew K Wszolek, Rosa Rademakers, Dennis W Dickson
BACKGROUND: Cognitive impairment is one of the core features of progressive supranuclear palsy. This study aimed to clarify the profile of cognitive impairment and its underlying pathology in progressive supranuclear palsy. METHODS: We retrospectively reviewed medical records to evaluate the pattern and severity of cognitive impairment in 121 autopsy-confirmed progressive supranuclear palsy patients. A subset of 37 patients underwent neuropsychological evaluation as part of their clinical workup...
October 30, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29076559/genetic-influences-on-cognition-in-progressive-supranuclear-palsy
#6
Adam Gerstenecker, Erik D Roberson, Gerard D Schellenberg, David G Standaert, David R Shprecher, Benzi M Kluger, Irene Litvan
BACKGROUND: Cognitive dysfunction is common in progressive supranuclear palsy, but the influence of genetics on cognition in this disorder has not been well studied. The objective of this study was to investigate the effect of genes previously identified as risk alleles, including microtubule-associated protein tau, myelin-associated oligodendrocyte basic protein, eukaryotic translation initiation factor 2-alpha kinase 3, and syntaxin 6, as well as apolipoprotein E, on cognitive function in progressive supranuclear palsy...
October 27, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29072042/active-exergames-to-improve-cognitive-functioning-in-neurological-disabilities-a-systematic-review-and-meta-analysis
#7
Gioia Mura, Mauro G Carta, Federica Sancassiani, Sergio Machado, Luca Prosperini
INTRODUCTION: Exergames represent a way to perform physical activity through active video games, serving as potentially useful tool in the field of neurorehabilitation. However, little is known regarding the possible role of exergames in improving cognitive functions in persons suffering from neurological disabilities. EVIDENCE ACQUISITION: A search for relevant articles was carried out on PubMed/Medline, Scopus, PEDro, and Google Scholar. Only randomized controlled studies and non-randomized but controlled studies were retained...
October 25, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29070942/odor-selectivity-of-hyposmia-and-cognitive-impairment-in-patients-with-parkinson-s-disease
#8
Cheng-Jie Mao, Fen Wang, Ju-Ping Chen, Ya-Ping Yang, Jing Chen, Juan-Ying Huang, Chun-Feng Liu
OBJECTIVE: Hyposmia is one of the earliest non-motor features of Parkinson's disease (PD) and can precede the onset of motor symptoms by years. Most of the current olfactory detection tests are targeted at Western populations. The exact relationship between hyposmia and cognitive impairment is unknown. The purpose of the study was to find bromines that can effectively identify olfactory dysfunction and investigate the relationship between hyposmia and cognitive function in early, non-demented, drug-naïve patients with PD in the People's Republic of China...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29065116/serum-igf-1-is-associated-with-cognitive-functions-in-early-drug-na%C3%A3-ve-parkinson-s-disease
#9
Marina Picillo, Rosario Pivonello, Gabriella Santangelo, Claudia Pivonello, Riccardo Savastano, Renata Auriemma, Marianna Amboni, Sara Scannapieco, Angela Pierro, Annamaria Colao, Paolo Barone, Maria Teresa Pellecchia
OBJECTIVE: Cognitive deficits are common in Parkinson's disease (PD) since the early stages and many patients eventually develop dementia. Yet, occurrence of dementia in PD is unpredictable. Evidence supports the hypothesis that insulin-like growth factor-1 (IGF-1) is involved in cognitive deficits. Our aim was to evaluate the relationship between serum IGF-1 levels and neuropsychological scores in a large cohort of drug-naïve PD patients during the earliest stages of the disease. METHODS: Serum IGF-1 levels were determined in 405 early, drug-naïve PD patients and 191 healthy controls (HC) enrolled in the Parkinson's Progression Markers Initiative (PPMI)...
2017: PloS One
https://www.readbyqxmd.com/read/29063713/cognition-and-the-course-of-prodromal-parkinson-s-disease
#10
Daniel Weintraub, Lana M Chahine, Keith A Hawkins, Andrew Siderowf, Shirley Eberly, David Oakes, John Seibyl, Matthew B Stern, Kenneth Marek, Danna Jennings
BACKGROUND: Prospective data on cognition in prodromal Parkinson's disease are limited. The objectives of this study were to assess in prodromal PD (1) if baseline cognition predicts conversion to clinical PD, (2) if baseline dopamine transporter binding predicts longitudinal changes in cognition, and (3) if impaired olfaction predicts future cognitive decline. METHODS: Prodromal participants were 136 hyposmic individuals enrolled in the Parkinson Associated Risk Study...
October 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29056907/corrigendum-white-matter-changes-related-gait-and-executive-function-deficits-associations-with-age-and-parkinson-s-disease
#11
Jennifer Sartor, Kristina Bettecken, Felix P Bernhard, Marc Hofmann, Till Gladow, Tobias Lindig, Meltem Ciliz, Mara Ten Kate, Johanna Geritz, Sebastian Heinzel, Marije Benedictus, Philip Scheltens, Markus A Hobert, Walter Maetzler
[This corrects the article on p. 213 in vol. 9, PMID: 28713264.].
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29043468/cognitive-and-behavioral-disorders-in-parkinson-s-disease-an-update-i-cognitive-impairments
#12
Costanza Papagno, Luigi Trojano
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by motor symptoms such as rigidity, rest tremor, and bradykinesia. However, a growing body of evidence demonstrated that PD encompasses several non-motor disturbances as well, such as cognitive impairment. Cognitive defects can be present since early stages of the disease but tend to dominate the clinical picture as the disease progresses. Around 40% of patients with PD present with cognitive impairments in several cognitive domains including attention, working memory and executive functions, language, visuospatial skills, and episodic memory; in later stages of the disease, cognitive defects and associated behavioral disorders concur to determine clinically relevant PD-associated dementia...
October 17, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29037500/motor-behavioural-and-cognitive-correlates-of-fatigue-in-early-de-novo-parkinson-disease-patients
#13
M Siciliano, L Trojano, R De Micco, A De Mase, F Garramone, A Russo, G Tedeschi, A Tessitore
INTRODUCTION: Fatigue is one of the most common and disabling non-motor symptoms in Parkinson's disease (PD). The objective of this study was to determine prevalence and motor, behavioural, and cognitive correlates of distressing fatigue in early, de novo PD patients. METHODS: Eighty-one consecutive de novo PD patients (64% men; mean age 65.73 ± 8.26 years) underwent a comprehensive examination, including Parkinson's disease Fatigue Scale (PFS), Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale (PDSS), Beck Depression Inventory (BDI), Parkinson's Anxiety Scale (PAS), and Apathy Evaluation Scale (AES)...
October 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29034115/impulse-control-disorder-and-response-inhibition-alterations-in-parkinson-s-disease-a-rare-case-of-totally-absent-functionality-of-the-medial-prefrontal-cortex-and-review-of-literature
#14
Sara Palermo, Rosalba Morese, Maurizio Zibetti, Francesca Dematteis, Stefano Sirgiovanni, Mario Stanziano, Maria Consuelo Valentini, Leonardo Lopiano
This report illustrates a Parkinson's disease (PD) patient with impulse-control disorder (ICD) and selective impairment in response-inhibition abilities as revealed by the performance in a functional magnetic resonance imaging (fMRI) anterior cingulate cortex - sensitive go-nogo task. In line with hypothesis on the role of response-inhibition disabilities in the arising of impulsivity in PD, the patient completely failed the go-nogo task. Moreover, fMRI acquisition revealed absent task-sensitive activity in the anterior cingulate cortex, medial prefrontal, and orbitofrontal cortices for the contrast nogo versus go, which signifying that a hypo-function of this network could be associated with ICD...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/29032789/symptom-dimensions-of-depression-and-apathy-and-their-relationship-with-cognition-in-parkinson-s-disease
#15
Sarah M Szymkowicz, Vonetta M Dotson, Jacob D Jones, Michael S Okun, Dawn Bowers
OBJECTIVES: Both depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson's disease (PD). However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigated the relationship between symptom dimensions of depression and apathy, based on factors identified in Kirsch-Darrow et al. (2011), and memory and executive function in PD. METHODS: A sample of 138 non-demented individuals with PD (mean age=64...
October 16, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29021353/longitudinal-decline-of-driving-safety-in-parkinson-disease
#16
Ergun Y Uc, Matthew Rizzo, Amy M J O'Shea, Steven W Anderson, Jeffrey D Dawson
OBJECTIVE: To longitudinally assess and predict on-road driving safety in Parkinson disease (PD). METHODS: Drivers with PD (n = 67) and healthy controls (n = 110) drove a standardized route in an instrumented vehicle and were invited to return 2 years later. A professional driving expert reviewed drive data and videos to score safety errors. RESULTS: At baseline, drivers with PD performed worse on visual, cognitive, and motor tests, and committed more road safety errors compared to controls (median PD 38...
November 7, 2017: Neurology
https://www.readbyqxmd.com/read/29019160/the-role-of-cognitive-reserve-in-cognitive-aging-what-we-can-learn-from-parkinson-s-disease
#17
Nicoletta Ciccarelli, Maria Rita Lo Monaco, Domenico Fusco, Davide Liborio Vetrano, Giuseppe Zuccalà, Roberto Bernabei, Vincenzo Brandi, Maria Stella Pisciotta, Maria Caterina Silveri
Parkinson's disease (PD) typically occurs in elderly people and some degree of cognitive impairment is usually present. Cognitive reserve (CR) theory was proposed to explain the discrepancy between the degree of brain pathologies and clinical manifestations. We administered a comprehensive neuropsychological battery to 35 non-demented participants affected by PD. All participants underwent also the Cognitive Reserve Index questionnaire and the Brief Intelligence Test as proxies for CR. Relationships between CR and cognitive performance were investigated by linear regression analyses, adjusting for significant confounding factors...
October 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28987283/follow-up-study-the-influence-of-rtms-with-high-and-low-frequency-stimulation-on-motor-and-executive-function-in-parkinson-s-disease
#18
Judit Málly, Noemi Geisz, Elek Dinya
BACKGROUND: rTMS may influence on both cognitive and motor function in PD but the daily routine and the predictors of responders to rTMS are not known. OBJECTIVE/HYPOTHESIS: We hypothesized that the frequency and intensity of stimulation somehow relate to each other. Our goal was to select the optimal frequency with low intensity for PD. We clarified the importance of age in the effect of rTMS. METHODS: A total sixty-six patients with PD were included in the study...
October 5, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28986095/modulation-of-mitochondrial-dynamics-by-treadmill-training-to-improve-gait-and-mitochondrial-deficiency-in-a-rat-model-of-parkinson-s-disease
#19
Chieh-Sen Chuang, Jui-Chih Chang, Fu-Chou Cheng, Ko-Hung Liu, Hong-Lin Su, Chin-San Liu
PURPOSE: Parkinson's disease (PD) is a progressive degenerative central nervous system disorder that particularly impairs motor function. As PD advances, gait disorders become more pronounced and are often difficult to treat with current pharmacological therapies. Physical activity improves both mobility in and the daily living activities of patients with PD. Mitochondrial alterations and oxidative stress contribute to PD progression. Therefore, the association between mitochondria and exercise in PD and the implicated regulation of mitochondrial proteins was explored in this study...
October 3, 2017: Life Sciences
https://www.readbyqxmd.com/read/28985531/spatial-structure-normalises-working-memory-performance-in-parkinson-s-disease
#20
Sean J Fallon, Daniel Bor, Adam Hampshire, Roger A Barker, Adrian M Owen
Cognitive deficits are a frequent symptom of Parkinson's disease (PD), particularly in the domain of spatial working memory (WM). Despite numerous demonstrations of aberrant WM in patients, there is a lack of understanding about how, if at all, their WM is fundamentally altered. Most notably, it is unclear whether span - the yardstick upon which most WM models are built - is compromised by the disease. Moreover, it is also unknown whether WM deficits occur in all patients or only exist in a sub-group who are executively impaired...
September 1, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
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