Kah Poh Loh, Chandrika Sanapala, Marielle Jensen-Battaglia, Anish Rana, Michael B Sohn, Erin Watson, Nikesha Gilmore, Heidi D Klepin, Jason H Mendler, Jane Liesveld, Eric Huselton, Marissa LoCastro, Martha Susiarjo, Colleen Netherby-Winslow, AnnaLynn M Williams, Karen Mustian, Paula Vertino, Michelle C Janelsins
BACKGROUND: Older adults with myeloid malignancies are susceptible to treatment-related toxicities. Accelerated DNAm age, or the difference between DNA methylation (DNAm) age and chronological age, may be used as a biomarker of biological age to predict individuals at risk. In addition, cancer treatment can also lead to accelerated DNAm age. Exercise is a promising intervention to reduce or prevent functional, psychological, and cognitive impairments in older patients with myeloid malignancies, yet there is little evidence of the effects of exercise on DNAm age...
May 30, 2023: European Journal of Medical Research