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Post chemotherapy cognitive impairment

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https://www.readbyqxmd.com/read/29974933/cognitive-impairment-in-hodgkin-lymphoma-survivors
#1
Estherina Trachtenberg, Tatiana Mashiach, Rachel Ben Hayun, Tamar Tadmor, Tali Fisher, Judith Aharon-Peretz, Eldad J Dann
Cancer-related cognitive impairment (CRCI) is commonly reported post-chemotherapy in adults with solid tumours. Hodgkin lymphoma (HL) mostly affects young adults. Data regarding CRCI in HL survivors (HLS) are scarce. The current study aimed to objectively assess CRCI incidence and characteristics in HLS. HLS, who completed first-line (chemotherapy ± radiation) therapy and remained in complete remission for 6 months to 5 years from therapy end, were evaluated. Age- and education-matched healthy individuals served as controls (n = 14)...
July 5, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29969366/brain-morphology-and-information-processing-at-the-completion-of-chemotherapy-only-treatment-for-pediatric-acute-lymphoblastic-leukemia
#2
Simone Darling, Cinzia Rachele De Luca, Vicki Anderson, Maria McCarthy, Stephen Hearps, Marc Seal
BACKGROUND: Approximately 50% of survivors of childhood acute lymphoblastic leukemia (ALL) demonstrate cognitive impairments. However, the trajectory of change and contributing neuropathology is unclear, limiting our ability to tailor intervention content and timing. This study aimed to explore information processing abilities and brain morphology early post-treatment for pediatric ALL. PROCEDURE: Twenty-one children at the end of ALL treatment and 18 controls underwent neuropsychological assessment...
July 3, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29904964/self-reported-chemotherapy-related-cognitive-impairment-compared-with-cognitive-complaints-following-menopause
#3
Jennifer N Vega, Julie Dumas, Paul Newhouse
OBJECTIVE: Cancer-related cognitive impairment (CRCI) is commonly reported following the administration of cancer treatment. Current longitudinal studies, primarily in women with breast cancer, suggest that up to 35%-60% of patients exhibit persistent CRCI (pCRCI) following completion of chemotherapy. Complaints of subjective cognitive decline (SCD) are also commonly reported by women during and following the menopause transition in non-cancer patients. Although the majority of evidence for cognitive difficulties in cancer patients and survivors is attributed to chemotherapy, there is growing evidence to suggest that menopausal status can also influence cognitive function in cancer patients...
June 15, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29851136/gene-expression-dynamics-following-mithramycin-treatment-a-possible-model-for-post-chemotherapy-cognitive-impairment
#4
Eyal Asor, Dorit Ben-Shachar
Chemotherapy-induced cognitive changes is a major burden on a substantial number of cancer survivors. The mechanism of this sequel is unknown. In this study, we followed long-term effects of early in life mithramycin (MTR) treatment on behavior and on the normal course of alterations of gene expression in brain. Between post-natal days (PND) 7-10 male rats were divided into two groups, one receiving MTR (0.1mg/Kg s.c./day) and the other saline. At PND11, frontal cortex tissue samples were dissected from four rats from each group...
May 30, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29791867/longitudinal-assessment-of-chemotherapy-induced-changes-in-brain-and-cognitive-functioning-a-systematic-review
#5
REVIEW
Mingmei Li, Karen Caeyenberghs
In addition to the burden of a life-threatening diagnosis, cancer patients are struggling with adverse side-effects from cancer treatment. Chemotherapy has been linked to an array of cognitive impairments and alterations in brain structure and function ("chemobrain"). In this review, we summarized the existing evidence that evaluate the changes in cognitive functioning and brain with chemotherapy, as assessed using structural and functional MRI-based techniques in a longitudinal design. This review followed the latest PRISMA guidelines using Embase, Medline, PsychINFO, Scopus, and Web of Science databases with date restrictions from 2012-2017...
May 20, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29759139/identifying-cytokine-predictors-of-cognitive-functioning-in-breast-cancer-survivors-up-to-10-years-post-chemotherapy-using-machine-learning
#6
Ashley M Henneghan, Oxana Palesh, Michelle Harrison, Shelli R Kesler
INTRODUCTION: The purpose of this study is to explore 13 cytokine predictors of chemotherapy-related cognitive impairment (CRCI) in breast cancer survivors (BCS) 6 months to 10 years after chemotherapy completion using a multivariate, non-parametric approach. METHODS: Cross sectional data collection included completion of a survey, cognitive testing, and non-fasting blood from 66 participants. Data were analyzed using random forest regression to identify the most significant predictors for each of the cognitive test scores...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29683228/relationships-between-self-reported-sleep-quality-components-and-cognitive-functioning-in-breast-cancer-survivors-up-to-10-years-following-chemotherapy
#7
Ashley M Henneghan, Patricia Carter, Alexa Stuifbergan, Brennan Parmelee, Shelli Kesler
OBJECTIVE: Links have been made between aspects of sleep quality and cognitive function in breast cancer survivors (BCS), but findings are heterogeneous. The objective of this study is to examine relationships between specific sleep quality components (latency, duration, efficiency, daytime sleepiness, sleep disturbance, use of sleep aids) and cognitive impairment (performance and perceived), and determine which sleep quality components are the most significant contributors to cognitive impairments in BCS 6 months to 10 years post chemotherapy...
April 23, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29573086/electrochemical-measurement-of-dopamine-release-and-uptake-in-zebrafish-following-treatment-with-carboplatin
#8
Thomas M Field, Mimi Shin, Chase S Stucky, Joseph Loomis, Michael A Johnson
Post-chemotherapy cognitive impairment, also known as 'chemobrain,' is a neurological condition in which cognitive function is impaired as a result of cancer chemotherapy treatment. In this work, we used fast-scan cyclic voltammetry (FSCV) to measure electrically evoked dopamine release and uptake in whole brain preparations from zebrafish that have been treated with carboplatin, an agent associated with chemobrain. We administered carboplatin by addition to the fish's tank water or their food. One week of treatment with 100 μM carboplatin in the water was needed to significantly impair dopamine release (∼40 % of control); however, only one day of treatment through the zebrafish's food was needed to cause a similar impairment...
May 22, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29484542/evolution-of-neurocognitive-function-in-long-term-survivors-of-childhood-acute-lymphoblastic-leukemia-treated-with-chemotherapy-only
#9
Wei Liu, Yin Ting Cheung, Heather M Conklin, Lisa M Jacola, DeoKumar Srivastava, Vikki G Nolan, Hongmei Zhang, James G Gurney, I-Chan Huang, Leslie L Robison, Ching-Hon Pui, Melissa M Hudson, Kevin R Krull
PURPOSE: The purpose of this study was to determine the evolution of neurocognitive problems from therapy completion to long-term follow-up in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. METHODS: We evaluated whether attention problems observed at therapy completion evolve into long-term executive dysfunction in 158 survivors treated on a single institution protocol. Treatment data (high-dose intravenous methotrexate exposure [serum concentration] and triple intrathecal chemotherapy injections) were collected...
June 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29477301/physical-exercise-prevents-cognitive-impairment-by-enhancing-hippocampal-neuroplasticity-and-mitochondrial-function-in-doxorubicin-induced-chemobrain
#10
Hye-Sang Park, Chang-Ju Kim, Hyo-Bum Kwak, Mi-Hyun No, Jun-Won Heo, Tae-Woon Kim
Although chemotherapy increases the survival rate of patients with various cancers, such treatment can induce acute or long-term cognitive dysfunction a phenomenon known as post-chemotherapy cognitive impairment (PCCI) or "chemobrain." Exercise is known to positively affect brain function. Thus, the present study aimed to determine whether symptoms of chemobrain and disruptions in the neuroplasticity and functioning of hippocampal mitochondria can be prevented or relieved by exercise. Wistar rats were separated into the following groups: control, control plus exercise, chemobrain, and chemobrain plus exercise...
May 1, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29387526/performance-monitoring-in-lung-cancer-patients-pre-and-post-chemotherapy-using-fine-grained-electrophysiological-measures
#11
M Simó, A Gurtubay-Antolin, L Vaquero, J Bruna, A Rodríguez-Fornells
No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C +) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C -) prior to chemotherapy and a healthy control group (HC)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29315963/distinct-and-heterogeneous-trajectories-of-self-perceived-cognitive-impairment-among-asian-breast-cancer-survivors
#12
Terence Ng, Sreemanee Raaj Dorajoo, Yin Ting Cheung, Yick Ching Lam, Hui Ling Yeo, Maung Shwe, Yan Xiang Gan, Koon Mian Foo, Wei-Jen Kiley Loh, Si-Lin Koo, Amit Jain, Guek Eng Lee, Rebecca Dent, Yoon Sim Yap, Raymond Ng, Alexandre Chan
OBJECTIVES: Currently, there are no studies that have established the self-perceived cognitive trajectories experienced by breast cancer patients (BCPs) post-chemotherapy. Therefore, we characterized the long-term trajectory of self-perceived cognitive function among Asian early-stage BCPs using the minimal clinically important difference of a subjective measure of cognitive function. METHODS: Early-stage BCPs who received chemotherapy were recruited and assessed at 4 time points: Before chemotherapy initiation (T1), 6 weeks post-chemotherapy initiation (T2), 12 weeks post-chemotherapy initiation (T3), and 15-months post-chemotherapy initiation (T4)...
April 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29258453/evaluation-of-plasma-brain-derived-neurotrophic-factor-levels-and-self-perceived-cognitive-impairment-post-chemotherapy-a-longitudinal-study
#13
Terence Ng, Ying Yun Lee, Jung-Woo Chae, Angie Hui Ling Yeo, Maung Shwe, Yan Xiang Gan, Raymond C H Ng, Pat Pak Yan Chu, Chiea Chuen Khor, Han Kiat Ho, Alexandre Chan
BACKGROUND: Preliminary evidence suggests that changes in plasma brain-derived neurotrophic factor (BDNF) levels may contribute to the occurrence of chemotherapy-associated cognitive impairment (CACI), and a previous study suggested that carriers of the BDNF Met homozygous genotype are protected from CACI. METHODS: This multicenter, prospective cohort study involved chemotherapy-receiving early-stage breast cancer (ESBC) patients. Self-perceived cognitive function was longitudinally assessed using the validated FACT-Cog (ver...
December 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29228376/effects-of-cyclophosphamide-and-or-doxorubicin-in-a-murine-model-of-postchemotherapy-cognitive-impairment
#14
Timothy J Flanigan, Julie E Anderson, Ikram Elayan, Antiño R Allen, Sherry A Ferguson
Postchemotherapy cognitive impairment, or PCCI, is a common complaint, particularly among breast cancer patients. However, the exact nature of PCCI appears complex. To model the human condition, ovariectomized C57BL/6J mice were treated intravenous weekly for 4 weeks with saline, 2 mg/kg doxorubicin (DOX), 50 mg/kg cyclophosphamide (CYP), or DOX + CYP. For the subsequent 10 weeks, mice were assessed on several behavioral tests, including those measuring spatial learning and memory. After sacrifice, hippocampal spine density and morphology in the dentate gyrus, CA1, and CA3 regions were measured...
April 1, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29187817/predicting-long-term-cognitive-outcome-following-breast-cancer-with-pre-treatment-resting-state-fmri-and-random-forest-machine-learning
#15
Shelli R Kesler, Arvind Rao, Douglas W Blayney, Ingrid A Oakley-Girvan, Meghan Karuturi, Oxana Palesh
We aimed to determine if resting state functional magnetic resonance imaging (fMRI) acquired at pre-treatment baseline could accurately predict breast cancer-related cognitive impairment at long-term follow-up. We evaluated 31 patients with breast cancer (age 34-65) prior to any treatment, post-chemotherapy and 1 year later. Cognitive testing scores were normalized based on data obtained from 43 healthy female controls and then used to categorize patients as impaired or not based on longitudinal changes. We measured clustering coefficient, a measure of local connectivity, by applying graph theory to baseline resting state fMRI and entered these metrics along with relevant patient-related and medical variables into random forest classification...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29179739/subjective-cognitive-impairment-and-brain-structural-networks-in-chinese-gynaecological-cancer-survivors-compared-with-age-matched-controls-a-cross-sectional-study
#16
Yingchun Zeng, Andy S K Cheng, Ting Song, Xiujie Sheng, Yang Zhang, Xiangyu Liu, Chetwyn C H Chan
BACKGROUND: Subjective cognitive impairment can be a significant and prevalent problem for gynaecological cancer survivors. The aims of this study were to assess subjective cognitive functioning in gynaecological cancer survivors after primary cancer treatment, and to investigate the impact of cancer treatment on brain structural networks and its association with subjective cognitive impairment. METHODS: This was a cross-sectional survey using a self-reported questionnaire by the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) to assess subjective cognitive functioning, and applying DTI (diffusion tensor imaging) and graph theoretical analyses to investigate brain structural networks after primary cancer treatment...
November 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29179434/growth-of-malignant-extracranial-tumors-alters-micrornaome-in-the-prefrontal-cortex-of-tumorgraft-mice
#17
Anna Kovalchuk, Yaroslav Ilnytskyy, Rocio Rodriguez-Juarez, Amanda Katz, David Sidransky, Bryan Kolb, Olga Kovalchuk
A wide array of central nervous system complications, neurological deficits, and cognitive impairments occur and persist as a result of systemic cancer and cancer treatments. This condition is known as chemo brain and it affects over half of cancer survivors. Recent studies reported that cognitive impairments manifest before chemotherapy and are much broader than chemo brain alone, thereby adding in tumor brain as a component. The molecular mechanisms of chemo brain are under-investigated, and the mechanisms of tumor brain have not been analyzed at all...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29164505/network-level-dysconnectivity-in-patients-with-nasopharyngeal-carcinoma-npc-early-post-radiotherapy-longitudinal-resting-state-fmri-study
#18
Yingwei Qiu, Zheng Guo, Lujun Han, Yadi Yang, Jing Li, Shiliang Liu, Xiaofei Lv
In this study, we seek to longitudinally investigate the network-level functional connectivity (FC) alternations and its association with irradiation dose and cognition changes in the early stage post radiotherapy (RT) in nasopharyngeal carcinoma (NPC) patients. We performed independent component analysis (ICA) of resting state blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) from 39 newly diagnosed NPC patients before receiving treatment (baseline), and 3 months post-RT. the default mode network (DMN), salience network (SN), and executive control network (ECN) were extracted with well-validated software (GIFT)...
November 21, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29092778/cognitive-impairment-in-breast-cancer-survivors-treated-with-chemotherapy-depends-on-control-group-type-and-cognitive-domains-assessed-a-multilevel-meta-analysis
#19
REVIEW
Lori J Bernstein, Graham A McCreath, Zahra Komeylian, Jill B Rich
Women with breast cancer can experience persisting cognitive deficits post treatment. We conducted a multilevel meta-analysis of cognitive function in survivors treated with chemotherapy (Ch+) to estimate the magnitude of cognitive impairment relative to healthy (HC) and chemo-negative (Ch-) controls. Seventy-two studies published up to October 2016 involving 2939 Ch+ yielded 1594 effect sizes. Ch+ demonstrated overall cognitive impairment in comparison with HC but not with Ch-. Relative to HC, Ch+ showed impairment in attention/concentration, processing speed, language, immediate recall, delayed recall, and executive function...
October 29, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29073552/chemotherapy-induced-cognitive-impairments-white-matter-pathologies
#20
REVIEW
A Matsos, M Loomes, I Zhou, E Macmillan, I Sabel, E Rotziokos, W Beckwith, I N Johnston
Whilst chemotherapeutic agents show promising results in the amelioration of cancerous tumors, patients often experience cognitive disturbances associated with chemotherapy long after treatment has ceased. Research has suggested that the structural integrity of white matter fibres in the brain are susceptible to the harmful effects of chemotherapy. Post-chemotherapy, white matter tracts often display altered morphology with a reduction in glial cells such as oligodendrocytes. Demyelination, gliosis and leukoencephalopathy during or post chemotherapy is associated with changes in processing speed and IQ...
December 2017: Cancer Treatment Reviews
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