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Hye-Sang Park, Chang-Ju Kim, Hyo-Bum Kwak, Mi-Hyun No, Jun-Won Heo, Tae-Woon Kim
Although chemotherapy increases the survival rate of patients with various cancers, such treatment can induce acute or long-term cognitive dysfunction a phenomenon known as post-chemotherapy cognitive impairment (PCCI) or "chemobrain." Exercise is known to positively affect brain function. Thus, the present study aimed to determine whether symptoms of chemobrain and disruptions in the neuroplasticity and functioning of hippocampal mitochondria can be prevented or relieved by exercise. Wistar rats were separated into the following groups: control, control plus exercise, chemobrain, and chemobrain plus exercise...
May 1, 2018: Neuropharmacology
Katherine S McGilton, Riva Sorin-Peters, Elizabeth Rochon, Veronique Boscart, Mary Fox, Charlene H Chu, Steven C Stewart, Souraya Sidani
PURPOSE OF THE STUDY: This small scale study examined the influence of an interprofessional (IP) evidence based patient-centered communication intervention (PCCI), delivered by trained nurses in collaboration with Speech Language Pathologists, on patient outcomes in an active stroke rehabilitation setting. DESIGN AND METHODS: The setting constraints imposed the use of a single-group pretest and post-test design to determine the influence of the intervention on patient outcomes...
February 2018: Applied Nursing Research: ANR
D Y Wang, W G Xie, M M Xi, Z Li, B Wang
Objective: To analyze the changes and relationship of early hemodynamic indexes of patients with large area burns monitored by pulse contour cardiac output (PiCCO) monitoring technology, so as to assess the guiding value of this technology in the treatment of patients with large area burns during shock period. Methods: Eighteen patients with large area burns, confirming to the study criteria, were admitted to our unit from May 2016 to May 2017. Pulse contour cardiac output index (PCCI), systemic vascular resistance index (SVRI), global end-diastolic volume index (GEDVI), and extravascular lung water index (EVLWI) of patients were monitored by PiCCO instrument from admission to post injury day (PID) 7, and they were calibrated and recorded once every four hours...
January 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Timothy J Flanigan, Julie E Anderson, Ikram Elayan, Antiño R Allen, Sherry A Ferguson
Post-chemotherapy cognitive impairment, or PCCI, is a common complaint, particularly among breast cancer patients. However, the exact nature of PCCI appears complex. To model the human condition, ovariectomized C57BL/6J mice were treated iv weekly for 4 weeks with saline, 2 mg/kg doxorubicin (DOX), 50 mg/kg cyclophosphamide (CYP), or DOX+CYP. For the subsequent 10 weeks, mice were assessed on several behavioral tests, including those measuring spatial learning and memory. After sacrifice, hippocampal spine density and morphology in the dentate gyrus, CA1, and CA3 regions were measured...
December 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
Patrick M McDonough, Natalie L Prigozhina, Ranor C B Basa, Jeffrey H Price
Postchemotherapy cognitive impairment (PCCI) is commonly exhibited by cancer patients treated with a variety of chemotherapeutic agents, including the endocrine disruptor tamoxifen (TAM). The etiology of PCCI is poorly understood. Our goal was to develop high-throughput assay methods to test the effects of chemicals on neuronal function applicable to PCCI. Rat hippocampal neurons (RHNs) were plated in 96- or 384-well dishes and exposed to test compounds (forskolin [FSK], 17β-estradiol [ES]), TAM or fulvestrant [FUL], aka ICI 182,780) for 6-14 days...
July 2017: Assay and Drug Development Technologies
Alejandra Nieto, Holger Roehl, Helen Brown, Michael Adler, Pascal Chalus, Hanns-Christian Mahler
UNLABELLED: Container closure integrity (CCI) testing is required by different regulatory authorities in order to provide assurance of tightness of the container closure system against possible contamination, for example, by microorganisms. Microbial ingress CCI testing is performed by incubation of the container closure system with microorganisms under specified testing conditions. Physical CCI uses surrogate endpoints, such as coloration by dye solution ingress or gas flow (helium leakage testing)...
July 2016: PDA Journal of Pharmaceutical Science and Technology
Michael Froehner, Rainer Koch, Matthias Hübler, Manfred P Wirth
UNLABELLED: Estimating competing mortality is of paramount importance for prostate cancer screening candidates and men with early prostate cancer. An age-adjusted prostate cancer-specific comorbidity index (PCCI) was developed recently for this purpose in an unselected population of 1598 men. We validated this mortality index in a sample of 2961 patients who consecutively underwent radical prostatectomy between 1992 and 2007 at our institution. In patients with a PCCI of 0, 1-2, 3-4, 5-6, 7-9, and ≥10 who were selected for radical prostatectomy, the 10-yr competing mortality rates were 2%, 9%, 17%, 27%, 56%, and 0% (n=3), respectively, compared with 10%, 19%, 35%, 60%, 79%, and 99%, respectively, in the unselected development cohort...
May 2016: European Urology
Timothy J Daskivich, Lorna Kwan, Atreya Dash, Christopher Saigal, Mark S Litwin
PURPOSE: Accurate estimation of life expectancy is critical for men considering aggressive vs nonaggressive treatment of early stage prostate cancer. We created an age adjusted comorbidity index that predicts other cause mortality in men with prostate cancer. MATERIALS AND METHODS: We sampled 1,598 men consecutively diagnosed with prostate cancer between 1998 and 2004 at West Los Angeles and Long Beach Veterans Affairs hospitals. We used competing risks regression in testing and validation cohorts to determine the risk of nonprostate cancer related (ie other cause) mortality associated with age at diagnosis and PCCI score...
July 2015: Journal of Urology
Yonghao Xu, Xiaoqing Liu, Weiqun He, Yuanda Xu, Sibei Chen, Ling Sang, Huanshun Xiao, Lan Mai
OBJECTIVE: To evaluate the effect of time elapsed on continuous pulse contour cardiac output (PCCO) measurement in septic shock patients. METHODS: Data during February 2011 to February 2013 from 25 septic shock patients equipped with a pulse indicator continuous cardiac output (PiCCO) device in Department of Critical Care Medicine of Guangzhou Medical University were retrospectively analyzed. PCCO was recorded immediately before transpulmonary thermodilution (COTPTD) calibration...
September 2014: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
A C B Coutinho, F R Neto, P S S Beraldo
STUDY DESIGN: Cross-sectional study. OBJECTIVES: To validate heart rate (HR) indexes for the evaluation of energy expenditure during wheelchair propulsion in people with spinal cord injury (SCI). SETTING: SARAH Rehabilitation Hospital Network-Brasilia, Brazil. METHODS: Forty-eight men aged 29.0±7.8 years with a SCI between C6 and L3 causing complete motor impairment were enrolled in the study. The assessment consisted of 5 min of rest while seated in the wheelchair, followed by 5 min of wheelchair propulsion at a self-selected comfortable speed...
September 2014: Spinal Cord
F R Neto, A C B Coutinho, P S S Beraldo
STUDY DESIGN: Cross-sectional study. OBJECTIVES: To measure the reproducibility and responsiveness of heart rate indexes in measuring energy expenditure during wheelchair locomotion of adults with spinal cord injury (SCI). SETTING: SARAH Rehabilitation Hospital Network-Brasilia, Brazil. METHODS: The study consecutively enrolled 35 individuals with SCI. Volunteers propelled their wheelchairs at a self-selected and comfortable velocity around a circular track...
September 2014: Spinal Cord
Philipp Zimmer, Andreas Mierau, Wilhelm Bloch, Heiko K Strüder, Thorben Hülsdünker, Alexander Schenk, Leonie Fiebig, Freek T Baumann, Moritz Hahn, Nina Reinart, Michael Hallek, Thomas Elter
To assess the effects of chemoimmunotherapy on post-chemotherapy cognitive impairments (PCCI) in patients with B-cell non-Hodgkin lymphoma (NHL), we used objective and subjective measures of cognitive functions in combination with serum parameters and neuroelectric recordings. Self-perceived status of cognition, fatigue and emotional functioning were reduced in patients (n=30) compared to healthy controls (n=10). Cognitive performance was impaired in patients with NHL compared to controls and a norm sample (n=1179)...
February 2015: Leukemia & Lymphoma
Jean Alvarez, Fremonta L Meyer, David L Granoff, Allan Lundy
UNLABELLED: BACKGROUND AND HYPOTHESES: Postcancer cognitive impairment (PCCI) is observed in a substantial number of breast cancer survivors, persisting for as long as 20 years in some subgroups. Although compensatory strategies are frequently suggested, no restorative interventions have yet been identified. This study examined the feasibility of EEG biofeedback ("neurofeedback") and its potential effectiveness in reducing PCCI as well as the fatigue, sleep disturbance, and psychological symptoms that frequently accompany PCCI...
November 2013: Integrative Cancer Therapies
R Jancalek, I Svizenska, I Klusakova, P Dubovy
Interleukin-10 prevents transition of a physiological inflammatory reaction to a pathological state that may result in neuropathic pain. We studied bilateral changes of IL-10 protein levels in L4-L5 and C7-C8 dorsal root ganglia (DRG) after a chronic constriction injury (CCI) of either L4-L5 spinal nerves (pCCI) or the sciatic nerve (dCCI). Rats undergoing pCCI or dCCI were left to survive for 1, 3, 7 or 14 d, sham-operated rats for 3 or 14 d. After the survival time, C7-C8 and L4-L5 DRG were removed bilaterally from naïve, operated, and sham-operated rats and IL-10 protein was detected by immunohistochemical staining and measured using ELISA analysis...
August 26, 2011: Neuroscience Letters
Jian Li, Richard J Solomon
OBJECTIVE: The incidence of creatinine increases after intravenous contrast (postcontrast creatinine increases, PCCI) is controversial, ranging from 0% to >25%. We sought to determine what factors influenced these divergent estimates of PCCI incidence. Where possible, the association of PCCI with long-term adverse outcomes was also studied. MATERIALS AND METHODS: Both observational studies and prospective randomized trials were reviewed. Definitions of clinically significant PCCI, incidence of PCCI, and its association with baseline kidney function, the setting in which intravenous contrast was administered, and the short- and long-term consequences of PCCI were extracted...
August 2010: Investigative Radiology
Jing-yu Gong, Guo-ping Lu, Jun He, Zhu-jin Lu, Ling-en Zhang
OBJECTIVE: To investigate the effect of continuous veno-venous hemodiafiltration (CVVHDF) on endotoxin-induced acute lung injury (ALI) of piglets. METHODS: Eighteen piglets were randomly divided into three groups: control group (n = 6); heparin group (n = 6) and CVVHDF treatment group (n = 6). All the animals were anesthetized by muscle injection of ketamine (30 mg/kg), then placed in supine position, received continuous intravenous infusion of ketamine with the rate of 10 mg/(kgxh)...
May 2008: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
I V Zakharov, K S Deĭneka, G A Gazarian, I E Galankina, S D Klimovskiĭ, G Iu Prelovskaia, I S Babaian, N M Bikbova
The purpose of the study was to evaluate different methods of myocardial revascularization. Three hundred and twenty-two patients with non-stable stenocardia were divided into two groups: group one consisted of 226 patients with mono-, bi-, or tri-vascular lesion of the coronary arteries (CA), who underwent percutaneous coronary intervention (PCCI) on the symptom-related CA (128 patients) or coronary bypass surgery (CBS) without cardiopulmonary bypass (59 patients); group two consisted of 96 patients with tri-vascular lesion of CA only, who underwent CBS with cardiopulmonary bypass (CPB) (32 patients) or without CPB (52 patients)...
2007: Klinicheskaia Meditsina
Martin Boyle, Margherita Murgo, John Lawrence, Andrew Belessis, Yahya Shehabi
OBJECTIVE: To assess the ability to track changes in cardiac index (Delta CI) induced by volume loading using continuous pulsed heat thermodilution (CCO), and pulse contour (PCCO) cardiac output (CO) with transpulmonary thermodilution (TD(tp)) CO as reference. DESIGN: Prospective observational clinical trial. SETTING: Intensive care unit. PATIENTS: Twelve ventilated and sedated post-operative cardiac surgery patients...
August 2007: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
Martin Boyle, John Lawrence, Andrew Belessis, Margherita Murgo, Yahya Shehabi
Cardiac output (CO) can be measured using bolus thermodilution via a pulmonary artery catheter (PAC) and as continuous cardiac output (CCO), using pulsed heat thermoditution. Pulse contour cardiac output (PCCO) measures continuous CO by analysis of the arterial waveform after calibration with thermodilution CO. The Pulsion Medical Systems (PiCCO system) achieves this by transpulmonary aortic thermodilution (TDtpa). There is uncertainty regarding the agreement between TDtpa, CCO, and PCCO CO measurements in situations of rapid haemodynamic changes...
February 2007: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
P S Halvorsen, A Espinoza, R Lundblad, M Cvancarova, P K Hol, E Fosse, T I Tønnessen
BACKGROUND: Haemodynamic instability during off-pump coronary artery bypass surgery (OPCAB) may appear rapidly, and continuous monitoring of the cardiac index (CI) during the procedure is advisable. With the PiCCO monitor, CI can be measured continuously and almost real time with pulse-contour analysis and intermittently with transthoracic thermodilution. The agreement between pulmonal artery thermodilution CI (Tpa), transthoracic thermodilution CI (Tpc) and pulse-contour CI (PCCI) during OPCAB surgery has not been evaluated sufficiently...
October 2006: Acta Anaesthesiologica Scandinavica
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