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adaptogens

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https://www.readbyqxmd.com/read/29214921/heteropterys-tomentosa-a-juss-toxicological-and-adaptogenic-effects-in-experimental-models
#1
Géssica Alves Fraga, Sikiru Olaitan Balogun, Emilly Della Pascqua, Ruberlei Godinho de Oliveira, Guilherme Botelho, Eduarda Pavan, Thiago da Rosa Lima, Eudes Thiago Pereira Avila, Clarissa de Medeiros Amorim Krueger, Valdir Cechinel Filho, Amílcar Sabino Damazo, Domingos Tabajara de Oliveira Martins, Fabrício Azevedo Voltarelli
BACKGROUND: The constant pursuit of improved athletic performance characterizes high-performance sport and the use of medicinal plants as dietary supplements is becoming widespread among athletes to enhance long-term endurance performance. AIM: The present study evaluated the toxicity of Heteropterys tomentosa (HEHt) and its acute adaptogenic effects. METHODS: The in vitro safety profile was evaluated on CHO-k1 cells using the alamar Blue assay, at concentrations ranging from 3...
December 2017: Nutrition and Health
https://www.readbyqxmd.com/read/29050447/uncaria-tomentosa
#2
Valentina Della Valle
Uncaria tomentosa (U. tomentosa) or uña de gato, a species of vine of Rubiaceae family, was used from centuries in various medical conditions. Although there are no randomized controlled trials or published human outcome studies, some conditions reportedly improved by U. tomentosa include osteoarthritis, rheumatoid arthritis, prostatitis, viral illnesses and cancer (acting as a non-specific immunomodulantign agent) and it may also have potential as an immunomodulating adaptogen in cellular aging. The understanding of some specific mechanisms of molecular action leads to the demonstration of various anti-inflammatory, immunostimulating and protective effects...
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28986996/metabolite-profiling-of-ginsenosides-in-rat-plasma-urine-and-faeces-by-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study-after-oral-administration-of-panax-ginseng-extract
#3
Wei-Wei Dong, Xiong-Zhe Han, Jinhua Zhao, Fei-Liang Zhong, Rui Ma, Songquan Wu, Donghao Li, Lin-Hu Quan, Jun Jiang
Panax ginseng has been widely consumed as a functional food in the form of tea, powder, capsules, among others, and possesses a range of pharmacological activities including adaptogenic, immune-modulatory, anti-tumour, anti-aging, and anti-inflammatory effects. The aim of this study was to identify and quantify the major ginsenosides and their metabolites in rat plasma, urine, and faeces after administration of Panax ginseng extract by using LC-MS/MS. We collected rat plasma samples at 0.5, 1, 2, 4, 8, 12, 24, and 48 h, and the amounts of urine and faecal samples accumulated in 24 h...
October 7, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28968926/immunopotentiating-significance-of-conventionally-used-plant-adaptogens-as-modulators-in-biochemical-and-molecular-signalling-pathways-in-cell-mediated-processes
#4
REVIEW
Pardeep Kaur, Robin, Victor O Makanjuola, Rohit Arora, Balbir Singh, Saroj Arora
Natural products are of great surge in the identification of chemopreventive agents and biologically active molecules for the development of new promising therapeutic agents. These agents influence the cascade of biochemical and molecular signalling pathways involved in numerous physiological and pathological processes. The natural agents combat the dogma associated with the most dreaded, unconquered health concern and a multigenic disease- cancer. A category of plants known as adaptogens maintain perturbed homoeostasis, augment adaptations to noxious stimuli (exposure to cold, heat, pain, general stress, infectious organisms) and offer endurance to attenuate several disorders in human beings...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28873320/influence-of-rhodiola-rosea-on-the-heat-acclimation-process-in-young-healthy-men
#5
Saima Timpmann, Anthony C Hackney, Maria Tamm, Kairi Kreegipuu, Eve Unt, Vahur Ööpik
The adaptogen Rhodiola rosea (RR) may mitigate stress responses and have beneficial effects on endurance capacity (EC) and mental performance. Heat acclimation (HA) improves EC in the heat, but the potential impact of RR on the HA process is unknown. Therefore, our intent was to determine if RR has a positive impact on HA. Twenty male subjects (age, 22.5 ± 3.0 years) completed 2 EC tests involving walking (6 km·h(-1)) until volitional exhaustion in a climate chamber (air temperature, 42 °C; relative humidity, 18%) before (H1) and after (H2) an 8-day HA period...
September 5, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28868219/appraisal-of-biochemical-classes-of-radioprotectors-evidence-current-status-and-guidelines-for-future-development
#6
REVIEW
Krishnanand Mishra, Ghazi Alsbeih
The search for efficient radioprotective agents to protect from radiation-induced toxicity, due to planned or accidental radiation exposure, is still ongoing worldwide. Despite decades of research and development of widely different biochemical classes of natural and derivative compounds, a safe and effective radioprotector is largely unmet. In this comprehensive review, we evaluated the evidence for the radioprotective performance of classical thiols, vitamins, minerals, dietary antioxidants, phytochemicals, botanical and bacterial preparations, DNA-binding agents, cytokines, and chelators including adaptogens...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28867986/ecdysteroids-production-in-plant-in-vitro-cultures
#7
REVIEW
Barbara Thiem, Małgorzata Kikowska, Michał P Maliński, Dariusz Kruszka, Marta Napierała, Ewa Florek
Ecdysteroids are secondary metabolites, widely distributed in the animal and plant kingdoms. They have a wide range of pharmacological effects in vertebrates, including mammals, most of which are beneficial for humans. Therefore, they have become compounds of interest for the pharmaceutical industry due to their adaptogenic, anabolic, hypoglycaemic, hypocholesterolaemic and antimicrobial activities, which are still being researched. Nowadays, ecdysteroids are present as active ingredients in bodybuilding supplements...
2017: Phytochemistry Reviews: Proceedings of the Phytochemical Society of Europe
https://www.readbyqxmd.com/read/28855685/establishment-of-the-most-comprehensive-its2-barcode-database-to-date-of-the-traditional-medicinal-plant-rhodiola-crassulacaee
#8
Ruo-Wei Zhu, Yuan-Cong Li, Da-Lv Zhong, Jian-Qiang Zhang
The roots and rhizomes of Rhodiola crenulata and R. rosea have been used worldwide as adaptogens for hundreds of years. However, rapid growth in demand has resulted in merchants using other species of Rhodiola as adulterants. Here, we surveyed 518 individuals representing 47 of the 55 species in the genus, including 253 R. crenulata individuals from 16 populations and 98 R. rosea individuals from 11 populations, to evaluate the utility of the internal transcribed spacer 2 (ITS2) barcode for identification of Rhodiola species...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813475/evaluation-of-the-adaptogenic-potential-exerted-by-ginsenosides-rb1-and-rg1-against-oxidative-stress-mediated-neurotoxicity-in-an-in-vitro-neuronal-model
#9
Carlos Fernández-Moriano, Elena González-Burgos, Irene Iglesias, Rafael Lozano, M Pilar Gómez-Serranillos
BACKGROUND: Ginseng (Panax sp.) is a drug with multiple pharmacological actions that has been largely used in traditional medicines for the treatment of many health problems. In the therapy of neurodegenerative disorders, it has been employed due to its capacity to strengthen mental processes by enhancing cognitive performance and psychological function. Current work aimed at evaluating the adaptogenic potential of Rb1 and Rg1 against oxidative-stress mediated degeneration in a model of nervous cells...
2017: PloS One
https://www.readbyqxmd.com/read/28777368/-melatonin-known-problems-and-perspectives-of-clinical-usage
#10
A V Zakharov, E V Khivintseva, V F Pytin, M S Sergeeva, O I Antipov
The article discusses well-known and ongoing studies of mechanisms of action of melatonin. The main clinical effects of melatonin are discussed. The emphasis on the chronobiological effect of melatonin, its adaptogenic and anti-carcinogenic properties has been done in the article. The most frequent manifestations of epiphyseal melatonin deficiency are various functional disorders in the form of insomnia, anxiety or depressive disorders. Recommendations on the effective use of melatonin in its deficiency due to pathology are given...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28717330/an-experimental-evaluation-of-adaptogenic-potential-of-standardized-epipremnum-aureum-leaf-extract
#11
Sreemoy Kanti Das, Pinaki Sengupta, Mohd Shahimi Mustapha, Md Moklesur Rahman Sarker
BACKGROUND: Stress is a normal part of everyday life but chronic stress can lead to a variety of stress-related illnesses including hypertension, anxiety, and depression. In the present investigation, standardized leaf extract of Epipremnumaureum was evaluated for its anti-stress potential. MATERIALS AND METHODS: For the evaluation of anti-stress activity, groups of mice (n = 6) were subjected to forced swim stress and anoxic stress tolerance test in mice 1h after daily treatment of E...
April 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28706332/role-of-elsholtzia-communis-in-counteracting-stress-by-modulating-expression-of-hspa14-c-ebp-homologous-protein-nuclear-factor-erythroid-derived-2-like-2-factor-caspase-3-and-brain-derived-neurotrophic-factor-in-rat-hippocampus
#12
Chandana Choudhury Barua, Pompy Patowary, Arundhati Purkayastha, Prakash Haloi, Manab Jyoti Bordoloi
OBJECTIVE: Elsholtzia communis (Collett and Hemsl.) Diels has been widely distributed and is reported for many therapeutic effects. The present study aims to investigate the antistress activity of the leaf extract and its possible molecular mechanism. MATERIALS AND METHODS: Hydroethanolic extract of leaves of E. communis (100 and 200 mg/kg, p.o.) were administered for 7 days to stress-induced male Wistar rats. The experimental animals were divided into five groups (n = 6)...
March 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28696777/therapeutic-uses-of-triphala-in-ayurvedic-medicine
#13
REVIEW
Christine Tara Peterson, Kate Denniston, Deepak Chopra
AIM: The aim of this article is to review the current literature on the therapeutic uses and efficacy of Triphala. Herbal remedies are among the most ancient medicines used in traditional systems of healthcare such as Ayurveda. Triphala, a well-recognized and highly efficacious polyherbal Ayurvedic medicine consisting of fruits of the plant species Emblica officinalis (Amalaki), Terminalia bellerica (Bibhitaki), and Terminalia chebula (Haritaki), is a cornerstone of gastrointestinal and rejuvenative treatment...
August 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28693955/adaptogenic-potential-of-oxitard-in-experimental-chronic-stress-and-chronic-unpredictable-stress-induced-dysfunctional-homeostasis-in-rodents
#14
Brajnandan Kishor, Pooja Rai, Rakesh Bharatia, Sanjay Kumar, Sujeet Kumar Gupta, Anshuman Sinha
BACKGROUND: Oxitard, a polyherbal formulation comprising the extracts of Withania somnifera, Mangifera indica, Glycyrrhiza glabra, Daucus carota, Vitis vinifera, powders of Syzygium aromaticum, Yashada bhasma and Emblica officinalis; and oils of Triticum sativum. OBJECTIVE: Current study deals with the assessment of Oxitard (a marketed polyherbal formulation) for its adaptogenic potential in chronic unpredictable stress (CUS) and chronic stress (CS) induced dysfunctional homeostasis in rodents...
July 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28640972/understanding-adaptogenic-activity-specificity-of-the-pharmacological-action-of-adaptogens-and-other-phytochemicals
#15
REVIEW
Alexander Panossian
Adaptogens are stress-response modifiers that increase an organism's nonspecific resistance to stress by increasing its ability to adapt and survive. The classical reductionist model is insufficiently complex to explain the mechanistic aspects of the physiological notion of "adaptability" and the adaptogenic activity of adaptogens. Here, I demonstrate that (1) the mechanisms of action of adaptogens are impossible to rationally describe using the reductionist concept of pharmacology, whereas the network pharmacology approach is the most suitable method; and (2) the principles of systems biology and pharmacological networks appear to be more suitable for conceptualizing adaptogen function and are applicable to any phytochemical...
August 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28586505/cellular-stress-response-mechanisms-as-therapeutic-targets-of-ginsenosides
#16
REVIEW
Hong-Yi Qi, Li Li, Hui Ma
Ginseng, one of the most widely used traditional herbal medicines and dietary supplements, has historically been recognized as a tonic herb and adaptogen that can enhance the body's tolerance to various adversities. Ginsenosides are a diverse group of steroidal saponins that comprise the major secondary metabolites of ginseng and are responsible for its multiple pharmacological effects. Emerging evidence suggests that hormetic phytochemicals produced by environmentally stressed plants can activate the moderate cellular stress response mechanisms at a subtoxic level in humans, which may enhance tolerance against severe dysfunction or disease...
June 6, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28435048/morella-serrata-lam-killick-stabilizes-biomembrane-and-rejuvenates-sexual-competence-in-male-wistar-rats
#17
S Sabiu, A O T Ashafa
ETHNOPHARMACOLOGICAL RELEVANCE: Morella serrata L. is an indigenous medicinal plant to South and southern Africa with folkloric applications as aphrodisiac, laxative, antimicrobial, anti-inflammatory, analgesic, anti-hypertensive, antitussive and antidiabetic agent. AIM OF THE STUDY: This study evaluated the membrane stabilization and aphrodisiac potentials of its aqueous root extract in male Wistar rats. MATERIALS AND METHODS: While the membrane stabilization of the extract was investigated against bovine erythrocytes (BE), the male rats for the aphrodisiac study were randomized into five groups with animals in group 1 given sterile placebo and served as control...
June 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28419924/centrifugal-partition-chromatography-in-the-isolation-of-minor-ecdysteroids-from-cyanotis-arachnoidea
#18
Halima Meriem Issaadi, Yu-Chi Tsai, Fang-Rong Chang, Attila Hunyadi
Phytoecdysteroids are known for their various beneficial bioactivities in mammals including a non-hormonal anabolic and adaptogenic effect. Cyanotis arachnoidea extracts are extensively utilized worldwide as ecdysteroid-rich materials for various purposes, e.g. food supplementation, use in agriculture and aquaculture, etc. Preparative chromatography of ecdysteroids requires extensive use of methods of different selectivity, and only a very limited number of papers are available on related application of modern liquid-liquid chromatographic techniques...
June 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28400848/the-clinical-efficacy-and-safety-of-tulsi-in-humans-a-systematic-review-of-the-literature
#19
REVIEW
Negar Jamshidi, Marc M Cohen
Tulsi, also known as holy basil, is indigenous to the Indian continent and highly revered for its medicinal uses within the Ayurvedic and Siddha medical systems. Many in vitro, animal and human studies attest to tulsi having multiple therapeutic actions including adaptogenic, antimicrobial, anti-inflammatory, cardioprotective, and immunomodulatory effects, yet to date there are no systematic reviews of human research on tulsi's clinical efficacy and safety. We conducted a comprehensive literature review of human studies that reported on a clinical outcome after ingestion of tulsi...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28340474/studying-the-effects-of-natural-extracts-with-metabolomics-a-longitudinal-study-on-the-supplementation-of-healthy-rats-with-polygonum-cuspidatum-sieb-et-zucc
#20
Gregorio Peron, Jalal Uddin, Matteo Stocchero, Stefano Mammi, Elisabetta Schievano, Stefano Dall'Acqua
BACKGROUND: A longitudinal study was performed to evaluate the effects of Polygonum cuspidatum extract (standardized at 20% resveratrol) supplementation on healthy rats. The effects were explored by monitoring urinary metabolome changes using UPLC-HRMS and (1)H NMR-based approaches. The aim of the study was to explore the effects of P. cuspidatum supplementation on a healthy animal model using metabolomics, in order to determine possible modes of action and obtain information on bioactivity...
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
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