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https://www.readbyqxmd.com/read/29673152/beneficial-effect-of-ocimum-sanctum-linn-against-monocrotaline-induced-pulmonary-hypertension-in-rats
#1
Himanshu Meghwani, Pankaj Prabhakar, Soheb A Mohammed, Pamila Dua, Sandeep Seth, Milind P Hote, Sanjay K Banerjee, Sudheer Arava, Ruma Ray, Subir Kumar Maulik
BACKGROUND: The study was designed to explore any beneficial effect of Ocimum sanctum (Linn) (OS) in experimental pulmonary hypertension (PH) in rats. OS is commonly known as “holy basil” and “Tulsi” and is used in the Indian System of Medicine as antidiabetic, antioxidant, hepatoprotective, adaptogenic, and cardioprotective. METHODS: Monocrotaline (MCT) administration caused development of PH in rats after 28 days and rats were observed for 42 days...
April 17, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29623041/an-adaptogen-withaferin-a-ameliorates-in-vitro-and-in-vivo-pulmonary-fibrosis-by-modulating-the-interplay-of-fibrotic-matricelluar-proteins-and-cytokines
#2
Swarna Bale, Pooladanda Venkatesh, Manoj Sunkoju, Chandraiah Godugu
Pulmonary fibrosis (PF) is chronic lung disease with only two FDA approved clinically available drugs, with limited safety profile. Inadequate therapy motivated us to explore the effect of vimentin inhibitor Withaferin A, as an anti-fibrotic agent against TGF-β1-induced in vitro fibrotic events and Bleomycin induced in vivo fibrosis with an emphasis on epithelial to mesenchymal transition (EMT), extracellular matrix deposition (ECM), inflammation, and angiogenesis. In vitro EMT and fibrotic events were induced by TGF-β1 in alveolar epithelial cells and human fetal lung fibroblasts followed by treatment with Withaferin A (0...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29581730/the-impact-of-rhodiola-rosea-on-the-gut-microbial-community-of-drosophila-melanogaster
#3
Khachik E Labachyan, Dara Kiani, Evgueni A Sevrioukov, Samuel E Schriner, Mahtab Jafari
Background: The root extract of Rhodiola rosea has historically been used in Europe and Asia as an adaptogen, and similar to ginseng and Shisandra , shown to display numerous health benefits in humans, such as decreasing fatigue and anxiety while improving mood, memory, and stamina. A similar extract in the Rhodiola family, Rhodiola crenulata , has previously been shown to confer positive effects on the gut homeostasis of the fruit fly, Drosophila melanogaster. Although, R. rosea has been shown to extend lifespan of many organisms such as fruit flies, worms and yeast, its anti-aging mechanism remains uncertain...
2018: Gut Pathogens
https://www.readbyqxmd.com/read/29488506/-the-peculiarities-of-the-clinical-picture-and-treatment-of-inflammatory-ent-diseases-in-the-frequently-ill-children
#4
A I Kryukov, N L Kunel'skaya, A Yu Ivoilov, A I Machulin, V V Yanovsky
The objective of the present study was the analysis of the current state of the problem of the frequently ill children. The authors present the classification of the frequently ill children together with information concerning the influence of various factors on the incidence of pediatric pathologies with special reference to the major pathogenic agents responsible for the formation of the areas of chronic inflammation in the ENT organs of the children. The approaches to the treatment and rehabilitation of the patients belonging to this age group requiring the follow-up monitoring are considered...
2018: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29377921/adaptogenic-potential-of-royal-jelly-in-liver-of-rats-exposed-to-chronic-stress
#5
Douglas Carvalho Caixeta, Renata Roland Teixeira, Leonardo Gomes Peixoto, Helen Lara Machado, Nathalia Belele Baptista, Adriele Vieira de Souza, Danielle Diniz Vilela, Celso Rodrigues Franci, Foued Salmen Espindola
Restraint and cold stress increase both corticosterone and glycemia, which lead to oxidative damages in hepatic tissue. This study assessed the effect of royal jelly (RJ) supplementation on the corticosterone level, glycemia, plasma enzymes and hepatic antioxidant system in restraint and cold stressed rats. Wistar rats were allocated into no-stress, stress, no-stress supplemented with RJ and stress supplemented with RJ groups. Initially, RJ (200mg/Kg) was administered for fourteen days and stressed groups were submitted to chronic stress from the seventh day...
2018: PloS One
https://www.readbyqxmd.com/read/29325481/stress-management-and-the-role-of-rhodiola-rosea-a-review
#6
Ion-George Anghelescu, David Edwards, Erich Seifritz, Siegfried Kasper
OBJECTIVE: Stress describes the physiological reaction to threat or pressure, which manifests as physical symptoms of exhaustion or energy loss and psychological symptoms, including irritability or tension. If untreated, chronic stress or burnout may develop, both are areas of unmet medical need. Evidence-based treatment and prevention measures are needed. METHODS: Prevention strategies and existing treatment options for stress-related symptoms were evaluated to establish criteria for an adequate pharmacological approach to stress...
January 11, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29258552/effects-of-stevia-on-synaptic-plasticity-and-nadph-oxidase-level-of-cns-in-conditions-of-metabolic-disorders-caused-by-fructose
#7
V A Chavushyan, K V Simonyan, R M Simonyan, A S Isoyan, G M Simonyan, M A Babakhanyan, L E Hovhannisyian, Kh H Nahapetyan, L G Avetisyan, M A Simonyan
BACKGROUND: Excess dietary fructose intake associated with metabolic syndrome and insulin resistance and increased risk of developing type 2 diabetes. Previous animal studies have reported that diabetic animals have significantly impaired behavioural and cognitive functions, pathological synaptic function and impaired expression of glutamate receptors. Correction of the antioxidant status of laboratory rodents largely prevents the development of fructose-induced plurimetabolic changes in the nervous system...
December 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29214921/heteropterys-tomentosa-a-juss-toxicological-and-adaptogenic-effects-in-experimental-models
#8
Géssica Alves Fraga, Sikiru Olaitan Balogun, Emilly Della Pascqua, Ruberlei Godinho de Oliveira, Guilherme Botelho, Eduarda Pavan, Thiago da Rosa Lima, Eudes Thiago Pereira Avila, Clarissa de Medeiros Amorim Krueger, Valdir Cechinel Filho, Amílcar Sabino Damazo, Domingos Tabajara de Oliveira Martins, Fabrício Azevedo Voltarelli
BACKGROUND: The constant pursuit of improved athletic performance characterizes high-performance sport and the use of medicinal plants as dietary supplements is becoming widespread among athletes to enhance long-term endurance performance. AIM: The present study evaluated the toxicity of Heteropterys tomentosa (HEHt) and its acute adaptogenic effects. METHODS: The in vitro safety profile was evaluated on CHO-k1 cells using the alamar Blue assay, at concentrations ranging from 3...
December 2017: Nutrition and Health
https://www.readbyqxmd.com/read/29050447/uncaria-tomentosa
#9
Valentina Della Valle
Uncaria tomentosa (U. tomentosa) or uña de gato, a species of vine of Rubiaceae family, was used from centuries in various medical conditions. Although there are no randomized controlled trials or published human outcome studies, some conditions reportedly improved by U. tomentosa include osteoarthritis, rheumatoid arthritis, prostatitis, viral illnesses and cancer (acting as a non-specific immunomodulantign agent) and it may also have potential as an immunomodulating adaptogen in cellular aging. The understanding of some specific mechanisms of molecular action leads to the demonstration of various anti-inflammatory, immunostimulating and protective effects...
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28986996/metabolite-profiling-of-ginsenosides-in-rat-plasma-urine-and-faeces-by-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study-after-oral-administration-of-panax-ginseng-extract
#10
Wei-Wei Dong, Xiong-Zhe Han, Jinhua Zhao, Fei-Liang Zhong, Rui Ma, Songquan Wu, Donghao Li, Lin-Hu Quan, Jun Jiang
Panax ginseng has been widely consumed as a functional food in the form of tea, powder, capsules, among others, and possesses a range of pharmacological activities including adaptogenic, immune-modulatory, anti-tumour, anti-aging, and anti-inflammatory effects. The aim of this study was to identify and quantify the major ginsenosides and their metabolites in rat plasma, urine, and faeces after administration of Panax ginseng extract by using LC-MS/MS. We collected rat plasma samples at 0.5, 1, 2, 4, 8, 12, 24, and 48 h, and the amounts of urine and faecal samples accumulated in 24 h...
October 7, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28968926/immunopotentiating-significance-of-conventionally-used-plant-adaptogens-as-modulators-in-biochemical-and-molecular-signalling-pathways-in-cell-mediated-processes
#11
REVIEW
Pardeep Kaur, Robin, Victor O Makanjuola, Rohit Arora, Balbir Singh, Saroj Arora
Natural products are of great surge in the identification of chemopreventive agents and biologically active molecules for the development of new promising therapeutic agents. These agents influence the cascade of biochemical and molecular signalling pathways involved in numerous physiological and pathological processes. The natural agents combat the dogma associated with the most dreaded, unconquered health concern and a multigenic disease- cancer. A category of plants known as adaptogens maintain perturbed homoeostasis, augment adaptations to noxious stimuli (exposure to cold, heat, pain, general stress, infectious organisms) and offer endurance to attenuate several disorders in human beings...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28873320/influence-of-rhodiola-rosea-on-the-heat-acclimation-process-in-young-healthy-men
#12
Saima Timpmann, Anthony C Hackney, Maria Tamm, Kairi Kreegipuu, Eve Unt, Vahur Ööpik
The adaptogen Rhodiola rosea (RR) may mitigate stress responses and have beneficial effects on endurance capacity (EC) and mental performance. Heat acclimation (HA) improves EC in the heat, but the potential impact of RR on the HA process is unknown. Therefore, our intent was to determine if RR has a positive impact on HA. Twenty male subjects (age, 22.5 ± 3.0 years) completed 2 EC tests involving walking (6 km·h-1 ) until volitional exhaustion in a climate chamber (air temperature, 42 °C; relative humidity, 18%) before (H1) and after (H2) an 8-day HA period...
January 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28868219/appraisal-of-biochemical-classes-of-radioprotectors-evidence-current-status-and-guidelines-for-future-development
#13
REVIEW
Krishnanand Mishra, Ghazi Alsbeih
The search for efficient radioprotective agents to protect from radiation-induced toxicity, due to planned or accidental radiation exposure, is still ongoing worldwide. Despite decades of research and development of widely different biochemical classes of natural and derivative compounds, a safe and effective radioprotector is largely unmet. In this comprehensive review, we evaluated the evidence for the radioprotective performance of classical thiols, vitamins, minerals, dietary antioxidants, phytochemicals, botanical and bacterial preparations, DNA-binding agents, cytokines, and chelators including adaptogens...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28867986/ecdysteroids-production-in-plant-in-vitro-cultures
#14
REVIEW
Barbara Thiem, Małgorzata Kikowska, Michał P Maliński, Dariusz Kruszka, Marta Napierała, Ewa Florek
Ecdysteroids are secondary metabolites, widely distributed in the animal and plant kingdoms. They have a wide range of pharmacological effects in vertebrates, including mammals, most of which are beneficial for humans. Therefore, they have become compounds of interest for the pharmaceutical industry due to their adaptogenic, anabolic, hypoglycaemic, hypocholesterolaemic and antimicrobial activities, which are still being researched. Nowadays, ecdysteroids are present as active ingredients in bodybuilding supplements...
2017: Phytochemistry Reviews: Proceedings of the Phytochemical Society of Europe
https://www.readbyqxmd.com/read/28855685/establishment-of-the-most-comprehensive-its2-barcode-database-to-date-of-the-traditional-medicinal-plant-rhodiola-crassulacaee
#15
Ruo-Wei Zhu, Yuan-Cong Li, Da-Lv Zhong, Jian-Qiang Zhang
The roots and rhizomes of Rhodiola crenulata and R. rosea have been used worldwide as adaptogens for hundreds of years. However, rapid growth in demand has resulted in merchants using other species of Rhodiola as adulterants. Here, we surveyed 518 individuals representing 47 of the 55 species in the genus, including 253 R. crenulata individuals from 16 populations and 98 R. rosea individuals from 11 populations, to evaluate the utility of the internal transcribed spacer 2 (ITS2) barcode for identification of Rhodiola species...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813475/evaluation-of-the-adaptogenic-potential-exerted-by-ginsenosides-rb1-and-rg1-against-oxidative-stress-mediated-neurotoxicity-in-an-in-vitro-neuronal-model
#16
Carlos Fernández-Moriano, Elena González-Burgos, Irene Iglesias, Rafael Lozano, M Pilar Gómez-Serranillos
BACKGROUND: Ginseng (Panax sp.) is a drug with multiple pharmacological actions that has been largely used in traditional medicines for the treatment of many health problems. In the therapy of neurodegenerative disorders, it has been employed due to its capacity to strengthen mental processes by enhancing cognitive performance and psychological function. Current work aimed at evaluating the adaptogenic potential of Rb1 and Rg1 against oxidative-stress mediated degeneration in a model of nervous cells...
2017: PloS One
https://www.readbyqxmd.com/read/28777368/-melatonin-known-problems-and-perspectives-of-clinical-usage
#17
A V Zakharov, E V Khivintseva, V F Pytin, M S Sergeeva, O I Antipov
The article discusses well-known and ongoing studies of mechanisms of action of melatonin. The main clinical effects of melatonin are discussed. The emphasis on the chronobiological effect of melatonin, its adaptogenic and anti-carcinogenic properties has been done in the article. The most frequent manifestations of epiphyseal melatonin deficiency are various functional disorders in the form of insomnia, anxiety or depressive disorders. Recommendations on the effective use of melatonin in its deficiency due to pathology are given...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28717330/an-experimental-evaluation-of-adaptogenic-potential-of-standardized-epipremnum-aureum-leaf-extract
#18
Sreemoy Kanti Das, Pinaki Sengupta, Mohd Shahimi Mustapha, Md Moklesur Rahman Sarker
BACKGROUND: Stress is a normal part of everyday life but chronic stress can lead to a variety of stress-related illnesses including hypertension, anxiety, and depression. In the present investigation, standardized leaf extract of Epipremnumaureum was evaluated for its anti-stress potential. MATERIALS AND METHODS: For the evaluation of anti-stress activity, groups of mice (n = 6) were subjected to forced swim stress and anoxic stress tolerance test in mice 1h after daily treatment of E...
April 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28706332/role-of-elsholtzia-communis-in-counteracting-stress-by-modulating-expression-of-hspa14-c-ebp-homologous-protein-nuclear-factor-erythroid-derived-2-like-2-factor-caspase-3-and-brain-derived-neurotrophic-factor-in-rat-hippocampus
#19
Chandana Choudhury Barua, Pompy Patowary, Arundhati Purkayastha, Prakash Haloi, Manab Jyoti Bordoloi
OBJECTIVE: Elsholtzia communis (Collett and Hemsl.) Diels has been widely distributed and is reported for many therapeutic effects. The present study aims to investigate the antistress activity of the leaf extract and its possible molecular mechanism. MATERIALS AND METHODS: Hydroethanolic extract of leaves of E. communis (100 and 200 mg/kg, p.o.) were administered for 7 days to stress-induced male Wistar rats. The experimental animals were divided into five groups (n = 6)...
March 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28696777/therapeutic-uses-of-triphala-in-ayurvedic-medicine
#20
REVIEW
Christine Tara Peterson, Kate Denniston, Deepak Chopra
AIM: The aim of this article is to review the current literature on the therapeutic uses and efficacy of Triphala. Herbal remedies are among the most ancient medicines used in traditional systems of healthcare such as Ayurveda. Triphala, a well-recognized and highly efficacious polyherbal Ayurvedic medicine consisting of fruits of the plant species Emblica officinalis (Amalaki), Terminalia bellerica (Bibhitaki), and Terminalia chebula (Haritaki), is a cornerstone of gastrointestinal and rejuvenative treatment...
August 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
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