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Freezing of gait executive

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https://www.readbyqxmd.com/read/30315142/cerebral-metabolic-changes-related-to-freezing-of-gait-in-parkinson-s-disease
#1
Trina Mitchell, Alexandra Potvin-Desrochers, Anne-Louise Lafontaine, Oury Monchi, Alexander Thiel, Caroline Paquette
Freezing of gait in Parkinson's disease often occurs during steering of gait (i.e., complex gait) which is thought to arise from executive dysfunction. Our aim was to test whether cognitive cortico-basal ganglia-thalamo cortical circuitry is impaired and whether alternate neural circuits are used for complex gait in Parkinson's disease with freezing of gait. Methods: Eighteen individuals with idiopathic Parkinson's disease in the OFF medication state, nine with freezing of gait (aged 68 ± 6) and nine without freezing (aged 65 ± 5) were included...
October 12, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30100532/decreasing-subthalamic-deep-brain-stimulation-frequency-reverses-cognitive-interference-during-gait-initiation-in-parkinson-s-disease
#2
Pasquale Varriale, Antoine Collomb-Clerc, Angele Van Hamme, Anaik Perrochon, Gilles Kemoun, Giuseppe Sorrentino, Nathalie George, Brian Lau, Carine Karachi, Marie-Laure Welter
OBJECTIVE: Freezing of gait (FOG) represents a major burden for Parkinson's disease (PD) patients. High-frequency (130-Hz) subthalamic deep-brain-stimulation (STN-DBS) has been reported to aggravate FOG whereas lowering the frequency to 60-80 Hz improves FOG. To further understand the effects of STN-DBS on FOG, we assessed the effects of 80-Hz and 130-Hz STN-DBS on gait initiation performance, in relation to motor and executive function processing. METHODS: Gait initiation was recorded in 19 PD patients and 20 controls, combined or not with a cognitive interference task with a modified Stroop paradigm...
November 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29985119/freezing-of-gait-in-parkinson-s-disease-functional-neuroimaging-studies-of-the-frontal-lobe
#3
María José Gallardo, Juan Pablo Cabello, María Jesus Corrales, Javier Torres-Donaire, Jose Javier Bravo, María Prado Talavera, Alberto León, Julia Vaamonde-Gamo
OBJECTIVE: The objective of the study is to study a group of patients with Parkinson's disease (PD) with and without freezing of gait (FOG) and analyze neuropsychological differences, especially regarding executive functions, according to their performance in a set of tests, and potential anomalies in functional positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-d-glucose integrated with computed tomography (18 F-FDG PET/CT) neuroimaging results of the frontal lobe. METHODS: The study recruited 23 patients...
October 2018: Neurological Research
https://www.readbyqxmd.com/read/29977280/effect-of-group-based-rehabilitation-combining-action-observation-with-physiotherapy-on-freezing-of-gait-in-parkinson-s-disease
#4
Elisa Pelosin, Roberta Barella, Cristina Bet, Elisabetta Magioncalda, Martina Putzolu, Francesca Di Biasio, Cecilia Cerulli, Mauro Casaleggio, Giovanni Abbruzzese, Laura Avanzino
Freezing of gait (FoG) is among the most disabling symptoms of Parkinson's disease (PD) patients. Recent studies showed that action observation training (AOT) with repetitive practice of the observed actions represents a strategy to induce longer-lasting effects compared with standard physiotherapy. We investigated whether AOT may improve FoG and mobility in PD, when AOT is applied in a group-based setting. Sixty-four participants with PD and FoG were assigned to the experimental (AO) or control groups and underwent a 45-minute training session, twice a week, for 5 weeks...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29956025/the-effects-of-anodal-tdcs-over-the-supplementary-motor-area-on-gait-initiation-in-parkinson-s-disease-with-freezing-of-gait-a-pilot-study
#5
Chiahao Lu, Sommer L Amundsen Huffmaster, Paul J Tuite, Colum D MacKinnon
OBJECTIVE: We investigated if anodal transcranial direct current stimulation (A-tDCS), applied over the supplementary motor areas (SMAs), could improve gait initiation in Parkinson's disease (PD) with freezing of gait (FOG). METHODS: In this double-blinded cross-over pilot study, ten PD with FOG underwent two stimulation sessions: A-tDCS (1 mA, 10 min) and sham stimulation. Eight blocks of gait initiation were collected per session: (1) pre-tDCS, with acoustic cueing; (2) pre-tDCS, self-initiated (no cue); and (3-8) post-tDCS, self-initiated...
September 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29860785/prospective-characterization-of-cognitive-function-in-typical-and-brainstem-predominant-progressive-supranuclear-palsy-phenotypes
#6
Young-Eun C Lee, David R Williams, Jacqueline F I Anderson
OBJECTIVE: Clinicopathological studies over the last decade have broadened the clinical spectrum of progressive supranuclear palsy (PSP) to include several distinct clinical syndromes. We examined the cognitive profiles of patients with PSP-Richardson's syndrome (PSP-RS) and two atypical 'brainstem predominant' PSP phenotypes (PSP-parkinsonism, PSP-P; and PSP-pure akinesia with gait freezing, PSP-PAGF) using a comprehensive neuropsychological battery. METHODS: Fourteen patients diagnosed as PSP-RS, three patients with PSP-P and four patients with PSP-PAGF were assessed using a comprehensive battery of neuropsychological tests...
May 2018: Journal of Movement Disorders
https://www.readbyqxmd.com/read/29796409/cognitive-training-for-freezing-of-gait-in-parkinson-s-disease-a-randomized-controlled-trial
#7
Courtney C Walton, Loren Mowszowski, Moran Gilat, Julie M Hall, Claire O'Callaghan, Alana J Muller, Matthew Georgiades, Jennifer Y Y Szeto, Kaylena A Ehgoetz Martens, James M Shine, Sharon L Naismith, Simon J G Lewis
The pathophysiological mechanism of freezing of gait (FoG) has been linked to executive dysfunction. Cognitive training (CT) is a non-pharmacological intervention which has been shown to improve executive functioning in Parkinson's disease (PD). This study aimed to explore whether targeted CT can reduce the severity of FoG in PD. Patients with PD who self-reported FoG and were free from dementia were randomly allocated to receive either a CT intervention or an active control. Both groups were clinician-facilitated and conducted twice-weekly for seven weeks...
2018: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29696615/influence-of-cognitive-impairment-on-the-freezing-of-gait-in-non-demented-people-with-parkinson-s-disease
#8
J M Cancela, C M Nascimento, S Varela, M Seijo-Martinez, L Lorenzo-Lopez, J C Millan-Calenti, C Dominguez-Vivero, C Ayan
INTRODUCTION: Freezing of gait (FOG) is a motor disturbance usually appearing in advanced Parkinson's disease (PD). Cognitive and executive function seems to play an important role in this phenomenon. AIM: To investigate if cognitive and kinematic parameters correlate with FOG in PD patients without dementia. PATIENTS AND METHODS: We conducted an observational cross-sectional study. Participants were classified in two groups: freezers and non-freezers...
May 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29571872/alterations-of-regional-homogeneity-in-freezing-of-gait-in-parkinson-s-disease
#9
Caihong Zhou, Xiaoling Zhong, Yongzhe Yang, Wanqun Yang, Lijuan Wang, Yuhu Zhang, Kun Nie, Jianmin Xu, Biao Huang
INTRODUCTION: Freezing of gait (FOG) is a serious complication in patients with Parkinson's disease (PD), and is more common in the late state of the disease. The high risk of falling in patients with FOG impacts their quality of life. OBJECTIVE: To explore altered neuroactivity related to cognitive and executive function of PD patients with FOG. METHODS: Fourteen PD patients with FOG (FOG+), 20 PD patients without FOG (FOG-), and 18 normal controls (NC) were enrolled...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29571090/impaired-set-shifting-is-associated-with-previous-falls-in-individuals-with-and-without-parkinson-s-disease
#10
J Lucas McKay, Kimberly C Lang, Lena H Ting, Madeleine E Hackney
BACKGROUND: Individuals with Parkinson's disease (PD) are at increased risk for falls, which lead to substantial morbidity and mortality. Understanding the motor and non-motor impairments associated with falls in PD is critical to informing prevention strategies. In addition to motor symptoms, individuals with PD exhibit non-motor deficits, including impaired set shifting, an aspect of executive function related to cognitive flexibility that can be measured quickly with the Trailmaking Test...
May 2018: Gait & Posture
https://www.readbyqxmd.com/read/29541542/predictors-of-freezing-of-gait-in-chinese-patients-with-parkinson-s-disease
#11
Ruwei Ou, Qianqian Wei, Bei Cao, Wei Song, Yanbing Hou, Hui Liu, Xiaoqin Yuan, Bi Zhao, Ying Wu, Huifang Shang
Objective: To explore the clinical predictors of freezing of gait (FOG) in Chinese patients with Parkinson's disease (PD). Methods: This study included 225 patients with PD who completed a three-year follow-up visit. The end-point was the presence of FOG (freezers), which was assessed during the follow-up visit. Group comparisons were conducted, followed by a further forward binary logistic regression analysis. Results: Eighty-five patients with PD (38%) had developed FOG at the end of study...
March 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29436740/multitarget-transcranial-direct-current-stimulation-for-freezing-of-gait-in-parkinson-s-disease
#12
Moria Dagan, Talia Herman, Rachel Harrison, Junhong Zhou, Nir Giladi, Giulio Ruffini, Brad Manor, Jeffrey M Hausdorff
BACKGROUND: Recent findings suggest that transcranial direct current stimulation of the primary motor cortex may ameliorate freezing of gait. However, the effects of multitarget simultaneous stimulation of motor and cognitive networks are mostly unknown. The objective of this study was to evaluate the effects of multitarget transcranial direct current stimulation of the primary motor cortex and left dorsolateral prefrontal cortex on freezing of gait and related outcomes. METHODS: Twenty patients with Parkinson's disease and freezing of gait received 20 minutes of transcranial direct current stimulation on 3 separate visits...
April 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29392774/gait-initiation-is-influenced-by-emotion-processing-in-parkinson-s-disease-patients-with-freezing
#13
Giovanna Lagravinese, Elisa Pelosin, Gaia Bonassi, Federico Carbone, Giovanni Abbruzzese, Laura Avanzino
BACKGROUND: Freezing of gait is a symptom that affects more than 50% of Parkinson's disease (PD) patients and increasing evidence suggests that nonmotor systems (i.e., limbic system) are involved in its underlying mechanisms. OBJECTIVE: The objective of this study was to investigate whether gait initiation characteristics are influenced by emotional stimuli in patients with PD, with or without freezing of gait. METHODS: A total of 44 participants, divided into 3 groups (15 PD patients with and 15 PD patients without freezing of gait and 14 controls), stood on a sensorized mat and were asked to take a step forward in response to a pleasant image and a step backward in response to an unpleasant one (congruent task, low cognitive load) or to take a step backward in response to a pleasant image and a step forward in response to an unpleasant one (incongruent task, high cognitive load)...
April 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29148136/effects-of-sensitive-electrical-stimulation-based-somatosensory-cueing-in-parkinson-s-disease-gait-and-freezing-of-gait-assessment
#14
Benoît Sijobert, Christine Azevedo, David Andreu, Claudia Verna, Christian Geny
This study aims to investigate the effect of a somatosensory cueing on gait disorders in subjects with Parkinson's disease (PD). After having performed stepping in place and timed up and go assessing tasks, 13 participants with PD were equipped with an electrical stimulator and an inertial measurement unit (IMU) located under the lateral malleolus on the sagittal plane. Electrodes were positioned under the arch of the foot and electrical stimulation (ES) parameters (five 500 µs/phase charge-balanced biphasic pulses delivered at 200 Hz, repeated four times at 10 Hz) adjusted to deliver a sensitive signal...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/28606769/computer-assisted-cognitive-rehabilitation-on-freezing-of-gait-in-parkinson-s-disease-a-pilot-study
#15
Valeria Dibilio, Alessandra Nicoletti, Giovanni Mostile, Giacomo Portaro, Antonina Luca, Francesco Patti, Mario Zappia
BACKGROUND: In Parkinson's Disease (PD), effects of a cognitive training have been systematically evaluated only for cognitive and behavioral outcome measures, with mild to moderate effects. Despite the demonstrated interplay between cognition and gait, no studies have investigated the effect of cognitive rehabilitation protocols on gait in PD. METHODS: Patients affected by PD with freezing of gait were treated twice a week for six weeks with one hour sessions of computer-assisted training of attention ability and information processing tasks...
July 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28398265/a-waist-worn-inertial-measurement-unit-for-long-term-monitoring-of-parkinson-s-disease-patients
#16
Daniel Rodríguez-Martín, Carlos Pérez-López, Albert Samà, Andreu Català, Joan Manuel Moreno Arostegui, Joan Cabestany, Berta Mestre, Sheila Alcaine, Anna Prats, María de la Cruz Crespo, Àngels Bayés
Inertial measurement units (IMUs) are devices used, among other fields, in health applications, since they are light, small and effective. More concretely, IMUs have been demonstrated to be useful in the monitoring of motor symptoms of Parkinson's disease (PD). In this sense, most of previous works have attempted to assess PD symptoms in controlled environments or short tests. This paper presents the design of an IMU, called 9 × 3, that aims to assess PD symptoms, enabling the possibility to perform a map of patients' symptoms at their homes during long periods...
April 11, 2017: Sensors
https://www.readbyqxmd.com/read/28283823/dietary-blueberry-improves-cognition-among-older-adults-in-a-randomized-double-blind-placebo-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Marshall G Miller, Derek A Hamilton, James A Joseph, Barbara Shukitt-Hale
PURPOSE: As populations shift to include a larger proportion of older adults, the necessity of research targeting older populations is becoming increasingly apparent. Dietary interventions with blueberry have been associated with positive outcomes in cell and rodent models of aging. We hypothesized that dietary blueberry would improve mobility and cognition among older adults. METHODS: In this study, 13 men and 24 women, between the ages of 60 and 75 years, were recruited into a randomized, double-blind, placebo-controlled trial in which they consumed either freeze-dried blueberry (24 g/day, equivalent to 1 cup of fresh blueberries) or a blueberry placebo for 90 days...
April 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/28263252/flexed-truncal-posture-in-parkinson-disease-measurement-reliability-and-relationship-with-physical-and-cognitive-impairments-mobility-and-balance
#18
Aimi L Forsyth, Serene S Paul, Natalie E Allen, Catherine Sherrington, Victor S C Fung, Colleen G Canning
BACKGROUND AND PURPOSE: Flexed truncal posture is common in people with Parkinson disease (PD); however, little is known about the mechanisms responsible or its effect on physical performance. This cross-sectional study aimed to establish the reliability of a truncal posture measurement and explore relationships between PD impairments and truncal posture, as well as truncal posture and balance and mobility. METHODS: A total of 82 people with PD participated. Truncal posture was measured in standing as the distance between vertebra C7 and a wall...
April 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28193533/effect-of-dual-mode-and-dual-site-noninvasive-brain-stimulation-on-freezing-of-gait-in-patients-with-parkinson-disease
#19
RANDOMIZED CONTROLLED TRIAL
Won Hyuk Chang, Min Soo Kim, Eunhee Park, Jin Whan Cho, Jinyoung Youn, Yun Kwan Kim, Yun-Hee Kim
OBJECTIVE: To investigate the effect of dual-mode noninvasive brain stimulation (NIBS) with high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex of the lower leg and anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex compared with rTMS alone in patients with Parkinson disease (PD) with freezing of gait (FOG). DESIGN: Randomized, double-blind, controlled study. SETTING: Outpatient rehabilitation clinics...
July 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28106569/cerebellar-volume-and-executive-function-in-parkinson-disease-with-and-without-freezing-of-gait
#20
Peter S Myers, Marie E McNeely, Jonathan M Koller, Gammon M Earhart, Meghan C Campbell
BACKGROUND: Freezing of gait (FOG) affects approximately 50% of people with Parkinson Disease (PD), impacting quality of life and placing financial and emotional strain on the individual and caregivers. People with PD and FOG have similar deficits in motor adaptation and cognition as individuals with cerebellar lesions, indicating the cerebellum may play a role in FOG. OBJECTIVE: To examine potential differences in cerebellar volumes and their relationships with cognition between PD with (FOG+) and without FOG (FOG-)...
2017: Journal of Parkinson's Disease
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