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Freezing of gait executive

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https://www.readbyqxmd.com/read/29148136/effects-of-sensitive-electrical-stimulation-based-somatosensory-cueing-in-parkinson-s-disease-gait-and-freezing-of-gait-assessment
#1
Benoît Sijobert, Christine Azevedo, David Andreu, Claudia Verna, Christian Geny
This study aims to investigate the effect of a somatosensory cueing on gait disorders in subjects with Parkinson's disease (PD). After having performed stepping in place and timed up and go assessing tasks, 13 participants with PD were equipped with an electrical stimulator and an inertial measurement unit (IMU) located under the lateral malleolus on the sagittal plane. Electrodes were positioned under the arch of the foot and electrical stimulation (ES) parameters (five 500 µs/phase charge-balanced biphasic pulses delivered at 200 Hz, repeated four times at 10 Hz) adjusted to deliver a sensitive signal...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/28606769/computer-assisted-cognitive-rehabilitation-on-freezing-of-gait-in-parkinson-s-disease-a-pilot-study
#2
Valeria Dibilio, Alessandra Nicoletti, Giovanni Mostile, Giacomo Portaro, Antonina Luca, Francesco Patti, Mario Zappia
BACKGROUND: In Parkinson's Disease (PD), effects of a cognitive training have been systematically evaluated only for cognitive and behavioral outcome measures, with mild to moderate effects. Despite the demonstrated interplay between cognition and gait, no studies have investigated the effect of cognitive rehabilitation protocols on gait in PD. METHODS: Patients affected by PD with freezing of gait were treated twice a week for six weeks with one hour sessions of computer-assisted training of attention ability and information processing tasks...
July 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28398265/a-waist-worn-inertial-measurement-unit-for-long-term-monitoring-of-parkinson-s-disease-patients
#3
Daniel Rodríguez-Martín, Carlos Pérez-López, Albert Samà, Andreu Català, Joan Manuel Moreno Arostegui, Joan Cabestany, Berta Mestre, Sheila Alcaine, Anna Prats, María de la Cruz Crespo, Àngels Bayés
Inertial measurement units (IMUs) are devices used, among other fields, in health applications, since they are light, small and effective. More concretely, IMUs have been demonstrated to be useful in the monitoring of motor symptoms of Parkinson's disease (PD). In this sense, most of previous works have attempted to assess PD symptoms in controlled environments or short tests. This paper presents the design of an IMU, called 9 × 3, that aims to assess PD symptoms, enabling the possibility to perform a map of patients' symptoms at their homes during long periods...
April 11, 2017: Sensors
https://www.readbyqxmd.com/read/28283823/dietary-blueberry-improves-cognition-among-older-adults-in-a-randomized-double-blind-placebo-controlled-trial
#4
Marshall G Miller, Derek A Hamilton, James A Joseph, Barbara Shukitt-Hale
PURPOSE: As populations shift to include a larger proportion of older adults, the necessity of research targeting older populations is becoming increasingly apparent. Dietary interventions with blueberry have been associated with positive outcomes in cell and rodent models of aging. We hypothesized that dietary blueberry would improve mobility and cognition among older adults. METHODS: In this study, 13 men and 24 women, between the ages of 60 and 75 years, were recruited into a randomized, double-blind, placebo-controlled trial in which they consumed either freeze-dried blueberry (24 g/day, equivalent to 1 cup of fresh blueberries) or a blueberry placebo for 90 days...
March 10, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28263252/flexed-truncal-posture-in-parkinson-disease-measurement-reliability-and-relationship-with-physical-and-cognitive-impairments-mobility-and-balance
#5
Aimi L Forsyth, Serene S Paul, Natalie E Allen, Catherine Sherrington, Victor S C Fung, Colleen G Canning
BACKGROUND AND PURPOSE: Flexed truncal posture is common in people with Parkinson disease (PD); however, little is known about the mechanisms responsible or its effect on physical performance. This cross-sectional study aimed to establish the reliability of a truncal posture measurement and explore relationships between PD impairments and truncal posture, as well as truncal posture and balance and mobility. METHODS: A total of 82 people with PD participated. Truncal posture was measured in standing as the distance between vertebra C7 and a wall...
April 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28193533/effect-of-dual-mode-and-dual-site-noninvasive-brain-stimulation-on-freezing-of-gait-in-patients-with-parkinson-disease
#6
RANDOMIZED CONTROLLED TRIAL
Won Hyuk Chang, Min Soo Kim, Eunhee Park, Jin Whan Cho, Jinyoung Youn, Yun Kwan Kim, Yun-Hee Kim
OBJECTIVE: To investigate the effect of dual-mode noninvasive brain stimulation (NIBS) with high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex of the lower leg and anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex compared with rTMS alone in patients with Parkinson disease (PD) with freezing of gait (FOG). DESIGN: Randomized, double-blind, controlled study. SETTING: Outpatient rehabilitation clinics...
July 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28106569/cerebellar-volume-and-executive-function-in-parkinson-disease-with-and-without-freezing-of-gait
#7
Peter S Myers, Marie E McNeely, Jonathan M Koller, Gammon M Earhart, Meghan C Campbell
BACKGROUND: Freezing of gait (FOG) affects approximately 50% of people with Parkinson Disease (PD), impacting quality of life and placing financial and emotional strain on the individual and caregivers. People with PD and FOG have similar deficits in motor adaptation and cognition as individuals with cerebellar lesions, indicating the cerebellum may play a role in FOG. OBJECTIVE: To examine potential differences in cerebellar volumes and their relationships with cognition between PD with (FOG+) and without FOG (FOG-)...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27872585/the-pedunculopontine-tegmental-nucleus-as-a-motor-and-cognitive-interface-between-the-cerebellum-and-basal-ganglia
#8
REVIEW
Fumika Mori, Ken-Ichi Okada, Taishin Nomura, Yasushi Kobayashi
As an important component of ascending activating systems, brainstem cholinergic neurons in the pedunculopontine tegmental nucleus (PPTg) are involved in the regulation of motor control (locomotion, posture and gaze) and cognitive processes (attention, learning and memory). The PPTg is highly interconnected with several regions of the basal ganglia, and one of its key functions is to regulate and relay activity from the basal ganglia. Together, they have been implicated in the motor control system (such as voluntary movement initiation or inhibition), and modulate aspects of executive function (such as motivation)...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27723662/pedunculopontine-nucleus-region-deep-brain-stimulation-in-parkinson-disease-surgical-anatomy-and-terminology
#9
Clement Hamani, Tipu Aziz, Bastiaan R Bloem, Peter Brown, Stephan Chabardes, Terry Coyne, Kelly Foote, Edgar Garcia-Rill, Etienne C Hirsch, Andres M Lozano, Paolo A M Mazzone, Michael S Okun, William Hutchison, Peter Silburn, Ludvic Zrinzo, Mesbah Alam, Laurent Goetz, Erlick Pereira, Anand Rughani, Wesley Thevathasan, Elena Moro, Joachim K Krauss
Several lines of evidence over the last few years have been important in ascertaining that the pedunculopontine nucleus (PPN) region could be considered as a potential target for deep brain stimulation (DBS) to treat freezing and other problems as part of a spectrum of gait disorders in Parkinson disease and other akinetic movement disorders. Since the introduction of PPN DBS, a variety of clinical studies have been published. Most indicate improvements in freezing and falls in patients who are severely affected by these problems...
2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27651150/investigating-motor-initiation-and-inhibition-deficits-in-patients-with-parkinson-s-disease-and-freezing-of-gait-using-a-virtual-reality-paradigm
#10
Matthew J Georgiades, Moran Gilat, Kaylena A Ehgoetz Martens, Courtney C Walton, Patrick G Bissett, James M Shine, Simon J G Lewis
Freezing of gait (FOG) is a common, disabling symptom of Parkinson's disease (PD) that is associated with deficits in motor initiation and inhibition. Understanding of underlying neurobiological mechanisms has been limited by difficulties in eliciting and objectively characterizing such gait phenomena in the clinical setting. However, recent work suggests that virtual reality (VR) techniques might offer the potential to study motor control. This study utilized a VR paradigm to explore deficits in motor initiation and stopping performance, including stop failure in PD patients with (Freezers, 31) and without (Non-Freezers, 23) FOG, and healthy age-matched Controls (15)...
November 19, 2016: Neuroscience
https://www.readbyqxmd.com/read/27469080/reducing-falls-in-parkinson-s-disease-interactions-between-donepezil-and-the-5-ht6-receptor-antagonist-idalopirdine-on-falls-in-a-rat-model-of-impaired-cognitive-control-of-complex-movements
#11
Aaron Kucinski, Inge E M de Jong, Martin Sarter
Falls are a leading cause of death in the elderly and, in a majority of patients with Parkinson's disease (PD), the leading levodopa-insensitive cause of hospitalization and long-term care. Falling in PD has been attributed to degeneration of forebrain cholinergic neurons that, in interaction with striatal dopamine losses, impairs the cognitive control of balance, gait, and movement. We previously established an animal model of these dual cholinergic-dopaminergic losses ("DL rats") and a behavioral test system (Michigan Complex Motor Control Task, MCMCT) to measure falls associated with traversing dynamic surfaces and distractors...
January 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27178858/freezing-of-gait-is-associated-with-increased-saccade-latency-and-variability-in-parkinson-s-disease
#12
Samuel T Nemanich, Gammon M Earhart
OBJECTIVE: Freezing of gait (FOG) is a locomotor disturbance in Parkinson disease (PD) related to impaired motor automaticity. In this study, we investigated the impact of freezing on automaticity in the oculomotor system using an anti-saccade paradigm. METHODS: Subjects with PD with (PD-FOG, n=13) and without (PD-NON, n=13) FOG, and healthy age-matched controls (CTRL, n=12) completed automatic pro-saccades and non-automatic anti-saccades. Primary outcomes were saccade latency, velocity, and gain...
June 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/26924977/bicycling-and-walking-are-associated-with-different-cortical-oscillatory-dynamics
#13
Lena Storzer, Markus Butz, Jan Hirschmann, Omid Abbasi, Maciej Gratkowski, Dietmar Saupe, Alfons Schnitzler, Sarang S Dalal
Although bicycling and walking involve similar complex coordinated movements, surprisingly Parkinson's patients with freezing of gait typically remain able to bicycle despite severe difficulties in walking. This observation suggests functional differences in the motor networks subserving bicycling and walking. However, a direct comparison of brain activity related to bicycling and walking has never been performed, neither in healthy participants nor in patients. Such a comparison could potentially help elucidating the cortical involvement in motor control and the mechanisms through which bicycling ability may be preserved in patients with freezing of gait...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/26693006/pilot-study-of-atomoxetine-in-patients-with-parkinson-s-disease-and-dopa-unresponsive-freezing-of-gait
#14
Gonzalo J Revuelta, Aaron Embry, Jordan J Elm, Chris Gregory, Amy Delambo, Steve Kautz, Vanessa K Hinson
BACKGROUND: Freezing of gait (FoG) is a common and debilitating condition in Parkinson's disease (PD) associated with executive dysfunction. A subtype of FoG does not respond to dopaminergic therapy and may be related to noradrenergic deficiency. This pilot study explores the effects of atomoxetine on gait in PD patients with dopa-unresponsive FoG using a novel paradigm for objective gait assessment. FINDINGS: Ten patients with PD and dopa-unresponsive FoG were enrolled in this eight-week open label pilot study...
2015: Translational Neurodegeneration
https://www.readbyqxmd.com/read/26483680/comparison-of-regional-brain-atrophy-and-cognitive-impairment-between-pure-akinesia-with-gait-freezing-and-richardson-s-syndrome
#15
Jin Yong Hong, Hyuk Jin Yun, Mun Kyung Sunwoo, Jee Hyun Ham, Jong-Min Lee, Young H Sohn, Phil Hyu Lee
Pure akinesia with gait freezing (PAGF) is considered a clinical phenotype of progressive supranuclear palsy. The brain atrophy and cognitive deficits in PAGF are expected to be less prominent than in classical Richardson's syndrome (RS), but this hypothesis has not been explored yet. We reviewed the medical records of 28 patients with probable RS, 19 with PAGF, and 29 healthy controls, and compared cortical thickness, subcortical gray matter volume, and neuropsychological performance among the three groups...
2015: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/26464101/antisaccade-errors-reveal-cognitive-control-deficits-in-parkinson-s-disease-with-freezing-of-gait
#16
Courtney C Walton, Claire O'Callaghan, Julie M Hall, Moran Gilat, Loren Mowszowski, Sharon L Naismith, James R Burrell, James M Shine, Simon J G Lewis
Freezing of gait is a poorly understood symptom of Parkinson's disease (PD) that is commonly accompanied by executive dysfunction. This study employed an antisaccade task to measure deficits in inhibitory control in patients with freezing, and to determine if these are associated with a specific pattern of grey matter loss using voxel-based morphometry. PD patients with (n = 15) and without (n = 11) freezing along with 10 age-matched controls were included. A simple prosaccade task was administered, followed by a second antisaccade task that required subjects to either look towards or away from a peripheral target...
December 2015: Journal of Neurology
https://www.readbyqxmd.com/read/26454703/identifying-freezing-of-gait-in-parkinson-s-disease-during-freezing-provoking-tasks-using-waist-mounted-accelerometry
#17
Heidemarie Zach, Arno M Janssen, Anke H Snijders, Arnaud Delval, Murielle U Ferraye, Eduard Auff, Vivian Weerdesteyn, Bastiaan R Bloem, Jorik Nonnekes
BACKGROUND: Freezing of gait (FOG) is a common and debilitating phenomenon in Parkinson's disease (PD). Wearable accelerometers might help to assess FOG in the research setting. Here, we evaluate whether accelerometry can detect FOG while executing rapid full turns and while walking with rapid short steps (the two most common provoking circumstances for FOG). METHODS: We included 23 PD patients, who all had objective FOG. Participants performed several walking tasks, including walking rapidly with short steps and rapid full turns in both directions with a triaxial linear waist-mounted accelerometer...
November 2015: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/26444088/freezing-of-gait-and-its-associations-in-the-early-and-advanced-clinical-motor-stages-of-parkinson-s-disease-a-cross-sectional-study
#18
Julie M Hall, James M Shine, Claire O'Callaghan, Courtney C Walton, Moran Gilat, Sharon L Naismith, Simon J G Lewis
BACKGROUND: Freezing of gait is a common disabling symptom of Parkinson's disease (PD) with limited treatment options. The pathophysiological mechanisms of freezing behaviour are still contentious. OBJECTIVE: To investigate the prevalence of freezing of gait and its associations with increasing disease severity to gain a better understanding of the underlying pathophysiology. METHODS: This exploratory study included 389 idiopathic PD patients, divided into four groups; early and advanced PD with freezing of gait, and early and advanced PD without freezing of gait...
2015: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/26395829/laserlight-visual-cueing-device-for-freezing-of-gait-in-parkinson-s-disease-a-case-study-of-the-biomechanics-involved
#19
C J Egerton, P McCandless, B Evans, J Janssen, J D Richards
BACKGROUND: Freezing of gait (FOG) is a serious gait disorder affecting up to two-thirds of people with Parkinson's disease (PD). Cueing has been explored as a method of generating motor execution using visual transverse lines on the floor. However, the impact of a laser light visual cue remains unclear. OBJECTIVE: To determine the biomechanical effect of a laser cane on FOG in a participant with PD compared to a healthy age- and gender-matched control. METHODS: The participant with PD and healthy control were given a task of initiating gait from standing...
2015: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/26394439/dual-motor-cognitive-virtual-reality-training-impacts-dual-task-performance-in-freezing-of-gait
#20
Isabelle Killane, Conor Fearon, Louise Newman, Conor McDonnell, Saskia M Waechter, Kristian Sons, Timothy Lynch, Richard B Reilly
Freezing of gait (FOG), an episodic gait disturbance characterized by the inability to generate effective stepping, occurs in more than half of Parkinson's disease patients. It is associated with both executive dysfunction and attention and becomes most evident during dual tasking (performing two tasks simultaneously). This study examined the effect of dual motor-cognitive virtual reality training on dual-task performance in FOG. Twenty community dwelling participants with Parkinson's disease (13 with FOG, 7 without FOG) participated in a pre-assessment, eight 20-minute intervention sessions, and a post-assessment...
November 2015: IEEE Journal of Biomedical and Health Informatics
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