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Parkinson's FOG

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https://www.readbyqxmd.com/read/28227901/identifying-montages-that-best-detect-the-electroencephalogram-power-spectrum-alteration-during-freezing-of-gait-in-parkinson-s-disease-patients
#1
Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Nghia Nguyen, Rifai Chai, Yvonne Tran, Simon J G Lewis, Hung T Nguyen, Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Nghia Nguyen, Rifai Chai, Yvonne Tran, Simon J G Lewis, Hung T Nguyen, Nghia Nguyen, A M Ardi Handojoseno, Moran Gilat, Hung T Nguyen, Yvonne Tran, Simon J G Lewis, Quynh Tran Ly, Rifai Chai
Our research team has previously used four Electroencephalography (EEG) leads to successfully detect and predict Freezing of Gait (FOG) in Parkinson's disease (PD). However, it remained to be determined whether these four sensor locations that were arbitrarily chosen based on their role in motor control are indeed the most optimal for FOG detection. The aim of this study was therefore to determine the most optimal location and combination of sensors to detect FOG amongst a 32-channel EEG montage using our EEG classification system...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226636/non-invasive-detection-of-the-freezing-of-gait-in-parkinson-s-disease-using-spectral-and-wavelet-features
#2
Kimia Nazarzadeh, Sridhar P Arjunan, Dinesh K Kumar, Debi Prasad Das, Kimia Nazarzadeh, Sridhar P Arjunan, Dinesh K Kumar, Debi Prasad Das, Debi Prasad Das, Dinesh K Kumar, Kimia Nazarzadeh, Sridhar P Arjunan
In this study, we have analyzed the accelerometer data recorded during gait analysis of Parkinson disease patients for detecting freezing of gait (FOG) episodes. The proposed method filters the recordings for noise reduction of the leg movement changes and computes the wavelet coefficients to detect FOG events. Publicly available FOG database was used and the technique was evaluated using receiver operating characteristic (ROC) analysis. Results show a higher performance of the wavelet feature in discrimination of the FOG events from the background activity when compared with the existing technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28199357/home-detection-of-freezing-of-gait-using-support-vector-machines-through-a-single-waist-worn-triaxial-accelerometer
#3
Daniel Rodríguez-Martín, Albert Samà, Carlos Pérez-López, Andreu Català, Joan M Moreno Arostegui, Joan Cabestany, Àngels Bayés, Sheila Alcaine, Berta Mestre, Anna Prats, M Cruz Crespo, Timothy J Counihan, Patrick Browne, Leo R Quinlan, Gearóid ÓLaighin, Dean Sweeney, Hadas Lewy, Joseph Azuri, Gabriel Vainstein, Roberta Annicchiarico, Alberto Costa, Alejandro Rodríguez-Molinero
Among Parkinson's disease (PD) symptoms, freezing of gait (FoG) is one of the most debilitating. To assess FoG, current clinical practice mostly employs repeated evaluations over weeks and months based on questionnaires, which may not accurately map the severity of this symptom. The use of a non-invasive system to monitor the activities of daily living (ADL) and the PD symptoms experienced by patients throughout the day could provide a more accurate and objective evaluation of FoG in order to better understand the evolution of the disease and allow for a more informed decision-making process in making adjustments to the patient's treatment plan...
2017: PloS One
https://www.readbyqxmd.com/read/28193533/effect-of-dual-mode-and-dual-site-non-invasive-brain-stimulation-on-freezing-of-gait-in-patients-with-parkinson-s-disease
#4
Won Hyuk Chang, Min Soo Kim, Eunhee Park, Jin Whan Cho, Jinyoung Youn, Yun Kwan Kim, Yun-Hee Kim
OBJECTIVE: To investigate the effect of dual-mode non-invasive brain stimulation (NIBS) with high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex of the lower leg and anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex compared with rTMS alone in patients with Parkinson's disease (PD) with freezing of gait (FOG). DESIGN: Randomized, double-blind, controlled study. SETTING: Outpatient rehabilitation clinics...
February 10, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28186875/freezing-of-gait-detection-in-parkinson-s-disease-a-subject-independent-detector-using-anomaly-scores
#5
Thuy T Pham, Steven T Moore, Simon J G Lewis, Diep N Nguyen, Eryk Dutkiewicz, Andrew J Fuglevand, Alistair L McEwan, Philip H W Leong
Freezing of gait (FoG) is common in Parkinsonian gait and strongly relates to falls. Current clinical FoG assessments are patients' self-report diaries and experts' manual video analysis. Both are subjective and yield moderate reliability. Existing detection algorithms have been predominantly designed in subject-dependent settings. In this work, we aim to develop an automated FoG detector for subject-independent. After extracting highly relevant features, we apply anomaly detection techniques to detect FoG events...
February 7, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28167093/effect-of-cue-timing-and-modality-on-gait-initiation-in-parkinson-s-disease-with-freezing-of-gait
#6
Chiahao Lu, Sommer L Amundsen Huffmaster, Paul J Tuite, Jacqueline M Vachon, Colum D MacKinnon
OBJECTIVE: To examine the effects of cue timing, across three sensory modalities, on anticipatory postural adjustments (APAs) during gait initiation in people with Parkinson's disease (PD). DESIGN: Observational study. SETTING: Biomechanics research laboratory. PARTICIPANTS: Twenty-five individuals with idiopathic PD (11 with freezing of gait, FOG) were studied in the off-levodopa state (12-hour overnight withdrawal)...
February 3, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28160752/motor-preparation-rather-than-decision-making-differentiates-parkinson-s-disease-patients-with-and-without-freezing-of-gait
#7
John S Butler, Conor Fearon, Isabelle Killane, Saskia M Waechter, Richard B Reilly, Timothy Lynch
OBJECTIVE: Freezing of gait (FOG) is a brief, episodic phenomenon affecting over half of people with Parkinson's disease (PD) and leads to significant morbidity. The pathophysiology of FOG remains poorly understood but is associated with deficits in cognitive function and motor preparation. METHOD: We studied 20 people with PD (10 with FOG, 10 without FOG) and performed a timed response target detection task while electroencephalographic data were acquired. We analysed the data to detect and examine cortical markers of cognitive decision making (P3b or centroparietal positivity, CPP) and motor readiness potential...
December 28, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28151878/a-training-approach-to-improve-stepping-automaticity-while-dual-tasking-in-parkinson-s-disease-a-prospective-pilot-study
#8
Taylor Chomiak, Alexander Watts, Nicole Meyer, Fernando V Pereira, Bin Hu
BACKGROUND: Deficits in motor movement automaticity in Parkinson's disease (PD), especially during multitasking, are early and consistent hallmarks of cognitive function decline, which increases fall risk and reduces quality of life. This study aimed to test the feasibility and potential efficacy of a wearable sensor-enabled technological platform designed for an in-home music-contingent stepping-in-place (SIP) training program to improve step automaticity during dual-tasking (DT). METHODS: This was a 4-week prospective intervention pilot study...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28113199/smart-gait-aid-glasses-for-parkinson-s-disease-patients
#9
DaeHan Ahn, Hyerim Chung, Ho-Won Lee, Kyunghun Kang, Pan-Woo Ko, Nam Sung Kim, Taejoon Park
Parkinson's disease (PD) is a chronic progressive disease caused by loss of dopaminergic neurons in the substantia nigra, degenerating the nervous system of a patient over time. Freezing of gait (FOG), which is a form of akinesia, is a symptom of PD. Meanwhile, recent studies show that the gait of PD patients experiencing FOG can be significantly improved by providing the regular visual or auditory patterns for the patients. In this paper, we propose a gait-aid system built upon smart glasses. Our system continuously monitors the gait and so on of a PD patient to detect FOG, and upon detection of FOG it projects visual patterns on the glasses as if the patterns were actually on the floor...
January 19, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28106569/cerebellar-volume-and-executive-function-in-parkinson-disease-with-and-without-freezing-of-gait
#10
Peter S Myers, Marie E McNeely, Jonathan M Koller, Gammon M Earhart, Meghan C Campbell
BACKGROUND: Freezing of gait (FOG) affects approximately 50% of people with Parkinson Disease (PD), impacting quality of life and placing financial and emotional strain on the individual and caregivers. People with PD and FOG have similar deficits in motor adaptation and cognition as individuals with cerebellar lesions, indicating the cerebellum may play a role in FOG. OBJECTIVE: To examine potential differences in cerebellar volumes and their relationships with cognition between PD with (FOG+) and without FOG (FOG-)...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27956066/the-clinical-significance-of-freezing-while-turning-in-parkinson-s-disease
#11
Martina Mancini, Katrijn Smulders, Rajal G Cohen, Fay B Horak, Nir Giladi, John G Nutt
Freezing of gait (FoG) in people with Parkinson's disease (PD) is an environmentally sensitive, intermittent problem that occurs most often during turning. FoG is difficult for clinicians to evaluate and treat because it can be difficult to elicit during a clinical visit. Here, we aimed to develop a clinically valid objective measure of freezing severity during a 2-min 360-degree turning-in-place. Twenty-eight subjects with PD (16 freezers, FoG+, and 12 nonfreezers, FoG-) in the "off" state and 14 healthy control subjects were tested...
February 20, 2017: Neuroscience
https://www.readbyqxmd.com/read/27766724/effect-of-high-frequency-subthalamic-neurostimulation-on-gait-and-freezing-of-gait-in-parkinson-s-disease-a-systematic-review-and-meta-analysis
#12
REVIEW
C Schlenstedt, A Shalash, M Muthuraman, D Falk, K Witt, G Deuschl
The aim of this meta-analysis was to summarize the short- and long-term effects of bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) on gait and freezing of gait (FOG) in Parkinson's disease and to detect predictors of post-stimulation outcome. A comprehensive review of the literature was conducted up to October 2015 using Medline Ovid databases for studies analyzing the effect of bilateral STN-DBS on FOG and/or gait. Sixteen studies with available data for the gait item (no. 29) of the Unified Parkinson's Disease Rating Scale (UPDRS) and six studies with the FOG item (no...
January 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27725534/transdermal-patch-of-rotigotine-attenuates-freezing-of-gait-in-patients-with-parkinson-s-disease-an-open-label-comparative-study-of-three-non-ergot-dopamine-receptor-agonists
#13
COMPARATIVE STUDY
Ken Ikeda, Takehisa Hirayama, Takanori Takazawa, Kiyokazu Kawabe, Yasuo Iwasaki
Objective Parkinson's disease (PD) is characterized by the progressive degeneration of the nigrostriatal dopaminergic neurons. Rotigotine is a non-ergot dopamine receptor agonist (DA). Its transdermal patch maintains the effective concentrations for 24 hours. Freezing of gait (FOG) is a common and devastating symptom in PD patients. Little is known about therapeutic effects of rotigotine on FOG in PD patients. Herein we compared how three non-ergot DAs of rotigotine, pramipexole LA and ropinirole CR influence FOG, besides classical motor deficits in PD patients...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27670977/effect-of-cumulative-repetitive-transcranial-magnetic-stimulation-on-freezing-of-gait-in-patients-with-atypical-parkinsonism-a-pilot-study
#14
RANDOMIZED CONTROLLED TRIAL
Won Hyuk Chang, Min Su Kim, Jin Whan Cho, Jinyoung Youn, Yun Kwan Kim, Sun Woong Kim, Ahee Lee, Yun-Hee Kim
OBJECTIVE: To investigate the potential of cumulative high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) on freezing of gait in atypical Parkinsonism. DESIGN: Randomized, single-blinded, crossover study with a blinded observer. PARTICIPANTS: Eight patients with atypical Parkinsonism. METHODS: All participants received HF-rTMS over the lower leg primary motor cortex (M1-LL) for 5 consecutive days. Alternative sham stimulation was also administered with a 2-week wash-out period...
October 12, 2016: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27662331/the-practicalities-of-assessing-freezing-of%C3%A2-gait
#15
Claudia Barthel, Elizabeth Mallia, Bettina Debû, Bastiaan R Bloem, Murielle Ursulla Ferraye
BACKGROUND: Freezing of gait (FOG) is a mysterious, complex and debilitating phenomenon in Parkinson's disease. Adequate assessment is a pre-requisite for managing FOG, as well as for assigning participants in FOG research. The episodic nature of FOG, as well as its multiple clinical expressions make its assessment challenging. OBJECTIVE: To highlight the available assessment tools and to provide practical, experience-based recommendations for reliable assessment of FOG...
October 19, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27651150/investigating-motor-initiation-and-inhibition-deficits-in-patients-with-parkinson-s-disease-and-freezing-of-gait-using-a-virtual-reality-paradigm
#16
Matthew J Georgiades, Moran Gilat, Kaylena A Ehgoetz Martens, Courtney C Walton, Patrick G Bissett, James M Shine, Simon J G Lewis
Freezing of gait (FOG) is a common, disabling symptom of Parkinson's disease (PD) that is associated with deficits in motor initiation and inhibition. Understanding of underlying neurobiological mechanisms has been limited by difficulties in eliciting and objectively characterizing such gait phenomena in the clinical setting. However, recent work suggests that virtual reality (VR) techniques might offer the potential to study motor control. This study utilized a VR paradigm to explore deficits in motor initiation and stopping performance, including stop failure in PD patients with (Freezers, 31) and without (Non-Freezers, 23) FOG, and healthy age-matched Controls (15)...
November 19, 2016: Neuroscience
https://www.readbyqxmd.com/read/27649270/physiology-of-freezing-of-gait
#17
REVIEW
Anke H Snijders, Kaoru Takakusaki, Bettina Debu, Andres M Lozano, Vibhor Krishna, Alfonso Fasano, Tipu Z Aziz, Stella M Papa, Stewart A Factor, Mark Hallett
Freezing of gait (FOG) is a common and debilitating, but largely mysterious, symptom of Parkinson disease. In this review, we will discuss the cerebral substrate of FOG focusing on brain physiology and animal models. Walking is a combination of automatic movement processes, afferent information processing, and intentional adjustments. Thus, normal gait requires a delicate balance between various interacting neuronal systems. To further understand gait control and specifically FOG, we will discuss the basic physiology of gait, animal models of gait disturbance including FOG, alternative etiologies of FOG, and functional magnetic resonance studies investigating FOG...
November 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27618783/patterns-and-predictors-of-freezing-of-gait-improvement-following-rasagiline-therapy-a-pilot-study
#18
Fariborz Rahimi, Angela C Roberts, Mandar Jog
OBJECTIVES: Freezing of gait (FoG) is a challenging clinical symptom in Parkinson's disease with variable improvements in FoG with rasagiline. In this prospective, uncontrolled, pre-/post- treatment pilot study, we explore the clinical variables that contribute to this variability and those that predict improvement. PATIENTS AND METHODS: Frequency and duration of FoG, along with other standardized scales, were evaluated in 18 optimally medicated PD participants with intractable FoG, prior to and after completion of a 90-day course of 1mg daily rasagiline...
November 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27599588/freezing-of-gait-in-parkinson-s-disease-from-pathophysiology-to-emerging-therapies
#19
Alberto Cucca, Milton C Biagioni, Jori E Fleisher, Shashank Agarwal, Andre Son, Pawan Kumar, Miroslaw Brys, Alessandro Di Rocco
Freezing of gait (FOG) is 'an episodic inability to generate effective stepping in the absence of any known cause other than parkinsonism or high level gait disorders'. FOG is one of the most disabling symptoms in Parkinson's disease, especially in its more advanced stages. Early recognition is important as FOG is related to higher fall risk and poorer prognosis. Although specific treatments are still elusive, there have been recent advances in the development of new therapeutic approaches. The aim of this review is to present the latest knowledge regarding the phenomenology, pathogenesis, diagnostic assessment and conventional treatment of FOG in Parkinson's disease...
October 2016: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/27589537/statistical-models-of-parkinson-s-disease-progression-predictive-validity-in-a-3-year-follow-up
#20
Alexandre Mendes, Alexandra Gonçalves, Nuno Vila-Chã, Margarida Calejo, Inês Moreira, Joana Fernandes, Joana Damásio, Armando Teixeira-Pinto, Paul Krack, António Bastos Lima, Sara Cavaco
BACKGROUND: The rate of Parkinson's disease (PD) progression varies widely between patients. Current knowledge does not allow to accurately predict the evolution of symptoms in a given individual over time. OBJECTIVES: To develop regression-based models of PD progression and to explore its predictive value in a three-year follow-up. METHODS: At baseline, 300 consecutive PD patients were assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) - subscales II and III, Hoehn & Yahr (H&Y) and Schwab and England Independence Scale (S&E); and the Freezing of Gait Questionnaire (FOG-Q)...
October 19, 2016: Journal of Parkinson's Disease
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