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Parkinson's FOG

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https://www.readbyqxmd.com/read/29243004/altered-effective-connectivity-contributes-to-micrographia-in-patients-with-parkinson-s-disease-and-freezing-of-gait
#1
Evelien Nackaerts, Alice Nieuwboer, Sanne Broeder, Stephan Swinnen, Wim Vandenberghe, Elke Heremans
Recently, it was shown that patients with Parkinson's disease (PD) and freezing of gait (FOG) can also experience freezing episodes during handwriting and present writing problems outside these episodes. So far, the neural networks underlying increased handwriting problems in subjects with FOG are unclear. This study used dynamic causal modeling of fMRI data to investigate neural network dynamics underlying freezing-related handwriting problems and how these networks changed in response to visual cues. Twenty-seven non-freezers and ten freezers performed a pre-writing task with and without visual cues in the scanner with their right hand...
December 14, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29198058/analyzing-gait-variability-and-dual-task-interference-in-patients-with-parkinson-s-disease-and-freezing-by-means-of-the-word-color-stroop-test
#2
Ana Francisca Rozin Kleiner, Aline S Pagnussat, Giulia di Prisco, Alessandro Vagnini, Fabrizio Stocchi, Maria Francesca De Pandis, Manuela Galli
The ability to carry out two tasks at once is critical to effective functioning in the real world and deficits are termed Dual-task interference or effect-DTE. DTE substantially compromised the gait of subjects with Parkinson's disease and freezing of gait (PD + FOG), leading to exaggerated slowing, increasing gait dysrhythmicity, and inducing FOG episodes. This study aimed to investigate the DTE in gait variability of subjects with PD and freezing of gait (PD + FOG). Thirty-three patients with PD + FOG and 14 healthy individuals (REFERENCE) took part at this study...
December 2, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29196699/altered-resting-state-brain-activity-in-parkinson-s-disease-patients-with-freezing-of-gait
#3
Tao-Mian Mi, Shan-Shan Mei, Pei-Peng Liang, Lin-Lin Gao, Kun-Cheng Li, Tao Wu, Piu Chan
Freezing of gait (FOG) is a common and debilitating symptom in Parkinson's disease (PD). The current study investigated alterations of resting-state spontaneous brain activity in PD patients with FOG. A total of 29 patients with FOG, 28 patients without FOG and 31 controls were included. All subjects underwent resting-state functional MRI, and the amplitude of low-frequency fluctuation (ALFF) was calculated to measure the spontaneous brain activity. Between-group differences and correlations with FOG severity (both subjective and objective measures) were analyzed...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29148136/effects-of-sensitive-electrical-stimulation-based-somatosensory-cueing-in-parkinson-s-disease-gait-and-freezing-of-gait-assessment
#4
Benoît Sijobert, Christine Azevedo, David Andreu, Claudia Verna, Christian Geny
This study aims to investigate the effect of a somatosensory cueing on gait disorders in subjects with Parkinson's disease (PD). After having performed stepping in place and timed up and go assessing tasks, 13 participants with PD were equipped with an electrical stimulator and an inertial measurement unit (IMU) located under the lateral malleolus on the sagittal plane. Electrodes were positioned under the arch of the foot and electrical stimulation (ES) parameters (five 500 µs/phase charge-balanced biphasic pulses delivered at 200 Hz, repeated four times at 10 Hz) adjusted to deliver a sensitive signal...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29128929/freezing-of-gait-in-parkinson-s-disease-gray-and-white-matter-abnormalities
#5
Sara Pietracupa, Antonio Suppa, Neeraj Upadhyay, Costanza Giannì, Giovanni Grillea, Giorgio Leodori, Nicola Modugno, Francesca Di Biasio, Alessandro Zampogna, Claudio Colonnese, Alfredo Berardelli, Patrizia Pantano
Freezing of gait (FOG) is a disabling disorder that often affects Parkinson's disease (PD) patients in advanced stages of the disease. To study structural gray matter (GM) and white matter (WM) changes in PD patients with and without FOG, twenty-one PD patients with FOG (PD-FOG), 16 PD patients without FOG (PD-nFOG) and 19 healthy subjects (HS) underwent a standardized MRI protocol. For the gray matter evaluation, cortical volume (CV), cortical thickness (CTh), and surface area (SA) were analyzed using the FreeSurfer pipeline...
November 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29114238/long-term-monitoring-gait-analysis-using-a-wearable-device-in-daily-lives-of-patients-with-parkinson-s-disease-the-efficacy-of-selegiline-hydrochloride-for-gait-disturbance
#6
Mutsumi Iijima, Hiroshi Mitoma, Shinichiro Uchiyama, Kazuo Kitagawa
Objective: The aim of this study was to assess quantitatively the gait disorders in the daily lives of patients with Parkinson's disease (PD) using with a newly developed portable gait rhythmogram (PGR), which has a trunk-mounted acceleration sensor and automatic gait-detection algorithm. Methods: Using the PGR, we recorded the daily walking profiles of 14 PD patients before and after the addition or increase in dose of an MAO-B inhibitor (selegiline, average dose: 4...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29111022/association-of-freezing-of-gait-with-nigral-iron-accumulation-in-patients-with-parkinson-s-disease
#7
Rajini M Naduthota, Arush Arun Honnedevasthana, Abhishek Lenka, Jitender Saini, Sairam Geethanath, Rose Dawn Bharath, Rita Christopher, Ravi Yadav, Arun Kumar Gupta, Pramod Kumar Pal
BACKGROUND AND PURPOSE: The objective of this work was to investigate whether patients with and without freezing of gait (FOG) in Parkinson's disease (PD) have differences in iron accumulation in substantia nigra using R2* relaxometry. MATERIALS AND METHODS: This study included seventeen PD patients with FOG [FOG (+)], equal number of age and gender matched patients without FOG [FOG (-)] and 34 healthy controls (HC). T2* images were obtained from a 3-Tesla MRI system using multi-echo sequence...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29089922/effects-of-subthalamic-and-nigral-stimulation-on-gait-kinematics-in-parkinson-s-disease
#8
Marlieke Scholten, Johannes Klemt, Melanie Heilbronn, Christian Plewnia, Bastiaan R Bloem, Friedemann Bunjes, Rejko Krüger, Alireza Gharabaghi, Daniel Weiss
Conventional subthalamic deep brain stimulation for Parkinson's disease (PD) presumably modulates the spatial component of gait. However, temporal dysregulation of gait is one of the factors that is tightly associated with freezing of gait (FOG). Temporal locomotor integration may be modulated differentially at distinct levels of the basal ganglia. Owing to its specific descending brainstem projections, stimulation of the substantia nigra pars reticulata (SNr) area might modulate spatial and temporal parameters of gait differentially compared to standard subthalamic nucleus (STN) stimulation...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29079421/a-prospective-study-of-falls-in-relation-to-freezing-of-gait-and-response-fluctuations-in-parkinson-s-disease
#9
Yasuyuki Okuma, Ana Lígia Silva de Lima, Jiro Fukae, Bastiaan R Bloem, Anke H Snijders
INTRODUCTION: Falls are a disabling feature of Parkinson's disease (PD). In this prospective study we investigated: (1) in which motor state patients with PD fallmost often; and (2) whether freezing of gait (FOG) and dyskinesias contribute to falls. METHODS: Patients with PD who had fallen at least once in the previous year and had wearing-off were recruited. During six months, patients complete a standardized fall report. We analyzed data regarding fall circumstances and motor state at the time of each first 10 falls...
October 19, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29060541/detection-of-gait-initiation-failure-in-parkinson-s-disease-based-on-wavelet-transform-and-support-vector-machine
#10
Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Rifai Chai, Kaylena A Ehgoetz Martens, Matthew Georgiades, Ganesh R Naik, Yvonne Tran, Simon J G Lewis, Hung T Nguyen
Gait initiation Failure (GIF) is the situation in which patients with Parkinson's disease (PD) feel as if their feet get "stuck" to the floor when initiating their first steps. GIF is a subtype of Freezing of Gait (FOG) and often leads to falls and related injuries. Understanding of neurobiological mechanisms underlying GIF has been limited by difficulties in eliciting and objectively characterizing such gait phenomena in the clinical setting. Studies investigating the effects of GIF on brain activity using EEG offer the potential to study such behavior...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060540/detection-of-turning-freeze-in-parkinson-s-disease-based-on-s-transform-decomposition-of-eeg-signals
#11
Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Rifai Chai, Kaylena A Ehgoetz Martens, Matthew Georgiades, Ganesh R Naik, Yvonne Tran, Simon J G Lewis, Hung T Nguyen
Freezing of Gait (FOG) is a highly debilitating and poorly understood symptom of Parkinson's disease (PD), causing severe immobility and decreased quality of life. Turning Freezing (TF) is known as the most common sub-type of FOG, also causing the highest rate of falls in PD patients. During a TF, the feet of PD patients appear to become stuck whilst making a turn. This paper presents an electroencephalography (EEG) based classification method for detecting turning freezing episodes in six PD patients during Timed Up and Go Task experiments...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060496/freezing-of-gait-detection-using-temporal-spatial-and-physiological-features-with-a-support-vector-machine-classifier
#12
Parisa Tahafchi, Rene Molina, Jaimie A Roper, Kristen Sowalsky, Chris J Hass, Aysegul Gunduz, Michael S Okun, Jack W Judy
Freezing-of-Gait (FoG) is a syndrome of Parkinson's disease defined by episodes when patients show a complete inability to take a step or continue with their locomotion. In order to develop closed-loop therapeutic strategies, including deep brain stimulation, a reliable means of detecting freezing episodes is required. By using wearable accelerometers, freezing episodes can be detected with energy-based algorithms when the ratio of the energy in the freeze band (3 to 8 Hz) to that of the locomotion band (0...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29031781/the-effectiveness-of-istradefylline-for-the-treatment-of-gait-deficits-and-sleepiness-in-patients-with-parkinson-s-disease
#13
Keita Matsuura, Hiroyuki Kajikawa, Ken-Ichi Tabei, Masayuki Satoh, Hirotaka Kida, Naoko Nakamura, Hidekazu Tomimoto
PURPOSE: Istradefylline is useful in treating the wearing-off state in Parkinson's disease (PD). We investigated the effectiveness of istradefylline (ISD) in improving arousal, sleep, and gait deficits in patients with PD. METHODS: We examined 14 patients with PD treated with ISD. We assessed the patients using the Unified Parkinson's Disease Rating Scale, Parkinson's Disease Questionnaire, Timed Up-and-Go test (TUG), Freezing of Gait Questionnaire (FOG-Q), Epworth Sleepiness Scale (ESS), and Parkinson's Disease Sleep Scale (PDSS) before and 1 month after ISD use...
October 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28980176/effects-of-dance-practice-on-functional-mobility-motor-symptoms-and-quality-of-life-in-people-with-parkinson-s-disease-a-systematic-review-with-meta-analysis
#14
REVIEW
Marcela Dos Santos Delabary, Isabel Giovannini Komeroski, Elren Passos Monteiro, Rochelle Rocha Costa, Aline Nogueira Haas
BACKGROUND: Patients with Parkinson's Disease (PD) undergo motor injuries, which decrease their quality of life (QL). Dance, added to drug therapy, can help treating these patients AIMS: To conduct a systematic review with meta-analysis with the aim to analyze the effects of dance classes in comparison to other interventions or to the absence of intervention, in randomized clinical trials (RCTs), on functional mobility, motor symptoms and QL of PD patients METHODS: The search was conducted in MEDLINE, LILACS, SciELO, Cochrane and PsycINFO (last searched in August 2017)...
October 4, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28928491/freezing-of-gait-is-associated-with-cortical-thinning-in-mesial-frontal-cortex
#15
Miroslav Vastik, Pavel Hok, Jan Valosek, Petr Hlustik, Katerina Mensikova, Petr Kanovsky
AIMS: The relationship between freezing of gait (FOG) and regional brain atrophy has been intensively investigated, but it is still not clearly understood. The study objective was to test whether grey matter (GM) atrophy contributes to FOG in Parkinson´s disease (PD) using a surface-based algorithm. METHODS: We investigated 21 patients with PD, 11 with FOG and 10 without FOG. Both groups were assessed using a FOG questionnaire and Hoehn and Yahr staging. High resolution T1-weighted brain images were acquired for each subject using a 1...
September 13, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28927894/freezing-related-perception-deficits-of-asymmetrical-walking-in-parkinson-s-disease
#16
Esther M J Bekkers, Wouter Hoogkamer, Aniek Bengevoord, Elke Heremans, Sabine M P Verschueren, Alice Nieuwboer
Patients with Parkinson's disease (PD), and especially those with freezing of gait (FOG), are known to experience impairments in gait rhythmicity, symmetry, and bilateral coordination between both legs. In the current study, we investigated whether deficits in perception of gait speed between limbs were more pronounced in freezers than in non-freezers and could explain some of these gait impairments. We also assessed cognitive ability and proprioception. Twenty-five PD patients (13 freezers, 12 non-freezers) and 12 healthy controls walked on a split-belt treadmill, while the speed of one of the belts was gradually increased...
November 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28890341/cueing-for-people-with-parkinson-s-disease-with-freezing-of-gait-a-narrative-review-of-the-state-of-the-art-and-novel-perspectives
#17
REVIEW
Pieter Ginis, Evelien Nackaerts, Alice Nieuwboer, Elke Heremans
Freezing, which manifests during gait and other movements, is an incapacitating motor symptom experienced by many patients with Parkinson's disease (PD). In rehabilitation, auditory and visual cueing methods are commonly applied to evoke a more goal-directed type of motor control and, as such, reduce freezing severity in patients with PD. In this narrative review, we summarize the current evidence regarding the effects of external cueing in patients with PD with freezing of gait (FOG) and provide suggestions on how to further improve cueing effectiveness with emerging technological developments...
September 7, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28890315/subthalamic-neural-entropy-is-a-feature-of-freezing-of-gait-in-freely-moving-people-with-parkinson-s-disease
#18
Judy Syrkin-Nikolau, Mandy Miller Koop, Thomas Prieto, Chioma Anidi, Muhammad Furqan Afzal, Anca Velisar, Zack Blumenfeld, Talora Martin, Megan Trager, Helen Bronte-Stewart
The goal of this study was to investigate subthalamic (STN) neural features of Freezers and Non-Freezers with Parkinson's disease (PD), while freely walking without freezing of gait (FOG) and during periods of FOG, which were better elicited during a novel turning and barrier gait task than during forward walking. METHODS: Synchronous STN local field potentials (LFPs), shank angular velocities, and ground reaction forces were measured in fourteen PD subjects (eight Freezers) off medication, OFF deep brain stimulation (DBS), using an investigative, implanted, sensing neurostimulator (Activa® PC+S, Medtronic, Inc...
September 7, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28886015/freezing-during-tapping-tasks-in-patients-with-advanced-parkinson-s-disease-and-freezing-of-gait
#19
Arnaud Delval, Luc Defebvre, Céline Tard
INTRODUCTION: Parkinson's disease patients with freezing of gait also experience sudden motor blocks (freezing) during other repetitive motor tasks. We assessed the proportion of patients with advanced PD and freezing of gait who also displayed segmental "freezing" in tapping tasks. METHODS: Fifteen Parkinson's disease patients with freezing of gait were assessed. Freezing of gait was evaluated using a standardized gait trajectory with the usual triggers. Patients performed repetitive tapping movements (as described in the MDS-UPDRS task) with the hands or the feet in the presence or absence of a metronome set to 4 Hz...
2017: PloS One
https://www.readbyqxmd.com/read/28860483/selective-lrrk2-kinase-inhibition-reduces-phosphorylation-of-endogenous-rab10-and-rab12-in-human-peripheral-mononuclear-blood-cells
#20
Kenneth Thirstrup, Justus C Dächsel, Felix S Oppermann, Douglas S Williamson, Garrick P Smith, Karina Fog, Kenneth V Christensen
Genetic variation in the leucine-rich repeat kinase 2 (LRRK2) gene is associated with risk of familial and sporadic Parkinson's disease (PD). To support clinical development of LRRK2 inhibitors as disease-modifying treatment in PD biomarkers for kinase activity, target engagement and kinase inhibition are prerequisite tools. In a combined proteomics and phosphoproteomics study on human peripheral mononuclear blood cells (PBMCs) treated with the LRRK2 inhibitor Lu AF58786 a number of putative biomarkers were identified...
August 31, 2017: Scientific Reports
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