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https://www.readbyqxmd.com/read/29470800/landiolol-a-review-in-tachyarrhythmias
#1
Yahiya Y Syed
Intravenous landiolol [Rapibloc® (EU)], an ultra short-acting highly cardioselective β1 -blocker, is approved in the EU for the rapid short-term control of tachyarrhythmias in the perioperative and intensive care settings. It has long been used in Japan to treat perioperative tachyarrhythmias. The efficacy of landiolol has been demonstrated in a large number of randomized controlled clinical trials. Landiolol significantly reduced heart rate in patients with postoperative or intraoperative supraventricular tachycardia relative to placebo and in those with atrial fibrillation/flutter and left ventricular dysfunction relative to digoxin...
February 22, 2018: Drugs
https://www.readbyqxmd.com/read/29467678/structural-immaturity-of-human-ipsc-derived-cardiomyocytes-in-silico-investigation-of-effects-on-function-and-disease-modeling
#2
Jussi T Koivumäki, Nikolay Naumenko, Tomi Tuomainen, Jouni Takalo, Minna Oksanen, Katja A Puttonen, Šárka Lehtonen, Johanna Kuusisto, Markku Laakso, Jari Koistinaho, Pasi Tavi
Background: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising experimental tool for translational heart research and drug development. However, their usability as a human adult cardiomyocyte model is limited by their functional immaturity. Our aim is to analyse quantitatively those characteristics and how they differ from adult CMs. Methods and Results: We have developed a novel in silico model with all essential functional electrophysiology and calcium handling features of hiPSC-CMs...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29467587/management-of-tizanidine-withdrawal-syndrome-a-case-report
#3
A Suárez-Lledó, A Padullés, T Lozano, S Cobo-Sacristán, M Colls, R Jódar
Most drugs that act on the central nervous system (CNS) require dose titration to avoid withdrawal syndrome. Tizanidine withdrawal syndrome is caused by adrenergic discharge due to its α2 -agonist mechanism and is characterized by hypertension, reflex tachycardia, hypertonicity, and anxiety. Although tizanidine withdrawal syndrome is mentioned as a potential side effect of cessation, it is not common and there have been few reports. We present the case of a 31-year-old woman with tizanidine withdrawal syndrome after discontinuing medication prescribed for a muscle contracture (tizanidine)...
2018: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/29466924/ventriculoatrial-synchrony-induced-heart-failure
#4
Stefan Andric, Dragica Tesic, Dalibor Somer, Ilija Srdanovic, Tatjana Miljkovic, Djordje G Jakovljevic, Lazar Velicki
OBJECTIVE AND IMPORTANCE: Endless loop tachycardia or pacemaker-mediated tachycardia, and atrioventricular desynchronization arrhythmia or repetitive non-reentrant ventriculoatrial synchrony (RNRVAS) are two forms of reverse impulse conduction - ventriculoatrial (VA) synchrony. Although VA synchrony can theoretically cause aggravation of heart failure, clinical cases describing severe consequential heart failure are lacking. CLINICAL PRESENTATION AND INTERVENTION: We describe a case of a 60-year-old patient who underwent primary percutaneous coronary intervention and mitral valve surgery...
February 21, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29465438/the-evolving-role-of-percutaneous-ventricular-assist-devices-in-high-risk-cardiac-patients
#5
Ilan A Marcuschamer, Aryeh Abelow, Ran Kornowski
The Impella is a mechanical circulatory support device that supports ventricular function. Since 2008, when the first Impella device received Food and Drug Administration clearance, its use has become increasingly prevalent. A variety of Impella devices are available, and are differentiated by size, power, and insertion techniques. These versions of the Impella have been used in a multitude of clinical scenarios, both emergent and elective, including high-risk coronary interventions, acute myocardial infarction complicated by cardiogenic shock, decompensated left and right heart failure, high-risk ventricular tachycardia ablations, and aortic valvuloplasty...
February 20, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29463610/impact-of-frequent-premature-ventricular-contractions-on-pregnancy-outcomes
#6
Calvin Tong, Marla Kiess, Marc William Deyell, Michael Qiu, Merav Orgad, Valerie Rychel, Ariel Claman, Emma Hardwick, Beverly McCarthy, Candice K Silversides, Jasmine Grewal
OBJECTIVES: To determine cardiac and fetal/neonatal event rates among pregnant women with premature ventricular contractions (PVCs) and compare with control groups. METHODS: Prospective case-control cohort study: 53 consecutive pregnancies in 49 women referred to the St. Paul's Hospital between 2010 and 2016 with PVC burden >1% in women without underlying cardiac disease. Maternal cardiac and fetal/neonatal outcomes were compared with two pregnant control groups: (1) supraventricular tachycardia (SVT) group of 53 women referred for a history of SVT/SVT in the current pregnancy and (2) low-risk group of 53 women with no cardiac disease...
February 20, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29460300/catheter-associated-venous-air-embolism-in-hospitalized-horses-32-cases
#7
Nicholas J Parkinson, Harold C McKenzie, Michelle H Barton, Jennifer L Davis, Bettina Dunkel, Amy L Johnson, Elizabeth S MacDonald
BACKGROUND: Venous air embolism is a potentially life-threatening complication of IV catheter use in horses. Despite widespread anecdotal reports of their occurrence, few cases have been reported in the literature and the prognosis is currently unknown. HYPOTHESIS/OBJECTIVES: Our objective was to describe the surrounding circumstances, clinical signs, treatment, progression, and outcome of venous air embolism in hospitalized horses. ANIMALS: Thirty-two horses with acute onset of compatible clinical signs associated with IV catheter disconnection or damage...
February 20, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29459505/acute-hemorrhagic-diarrhea-syndrome-associated-with-contaminated-foreign-bodies-used-feminine-hygiene-products-in-a-golden-retriever-dog
#8
Seung-Il Yang, Jung-Hyun Kim, Soon-Wuk Jeong, Hyun-Jung Han
A one-year-old male Golden Retriever presented with acute onset of vomiting and hemorrhagic diarrhea since 2 days. The dog was depressed, showing abdominal pain, 12% dehydration, tachycardia, and a bounding pulse. Diagnostic imaging showed severe dilatation and fluid retention of the entire gastrointestinal tract with decreased motility. A foreign body was found in the gastroduodenal region, but there was no obstruction or plication. The dog was tentatively diagnosed with acute hemorrhagic diarrhea syndrome and rapidly recovered after supportive treatment...
February 20, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29458703/a-case-of-narcolepsy-type-2-and-postural-tachycardia-syndrome-secondary-to-lesions-of-the-thalamus-and-amygdala
#9
Paul Kim, Emmanuel During, Mitchell Miglis
Although there are reports of narcolepsy type 1 caused by lesions of the central nervous system, there are far fewer reports of narcolepsy type 2 (NT2) caused by discrete brain lesions. We report a case of a patient in whom NT2 was diagnosed after a viral illness, and inflammatory lesions in the right thalamus and amygdala were found. In addition, symptoms of autonomic impairment developed and postural tachycardia syndrome was subsequently diagnosed in this patient. To our knowledge this is the first reported case of NT2 resulting from central nervous system lesions in these discrete locations, as well as the first reported case of postural tachycardia syndrome associated with narcolepsy...
February 13, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29458408/catheter-ablation-versus-thoracoscopic-surgical-ablation-in-long-standing-persistent-atrial-fibrillation-casa-af-study-protocol-for-a-randomised-controlled-trial
#10
Habib Rehman Khan, Ines Kralj-Hans, Shouvik Haldar, Toufan Bahrami, Jonathan Clague, Anthony De Souza, Darrel Francis, Wajid Hussain, Julian Jarman, David Gareth Jones, Neeraj Mediratta, Raad Mohiaddin, Tushar Salukhe, Simon Jones, Joanne Lord, Caroline Murphy, Joanna Kelly, Vias Markides, Dhiraj Gupta, Tom Wong
BACKGROUND: Atrial fibrillation is the commonest arrhythmia which raises the risk of heart failure, thromboembolic stroke, morbidity and death. Pharmacological treatments of this condition are focused on heart rate control, rhythm control and reduction in risk of stroke. Selective ablation of cardiac tissues resulting in isolation of areas causing atrial fibrillation is another treatment strategy which can be delivered by two minimally invasive interventions: percutaneous catheter ablation and thoracoscopic surgical ablation...
February 20, 2018: Trials
https://www.readbyqxmd.com/read/29455831/thoracoscopic-sympathectomy-for-refractory-electrical-storm-after-coronary-artery-bypass-grafting
#11
Brody Wehman, Michael Mazzeffi, Robert Chow, A Claire Watkins, Brittany Aicher, Si Pham, Whitney Burrows, Bradley Taylor
We report a patient with refractory electrical storm after coronary artery bypass grafting who was successfully treated with thoracoscopic sympathectomy. Cardiac arrest with ventricular tachycardia occurred on postoperative day 2, and the patient required emergency support with venoarterial extracorporeal membrane oxygenation. Frequent episodes of ventricular tachycardia prevented cardiac recovery and weaning from mechanical circulatory support. A percutaneous left stellate ganglion block initially demonstrated successful prevention of ventricular tachycardia, and definitive sympathetic denervation was achieved by a left thoracoscopic sympathectomy...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29455427/variation-in-cardiac-markers-and-electrocardiographic-alterations-in-young-calves-naturally-infected-with-bovine-tropical-theileriosis
#12
Kapil Kumar Gupta, Mukesh Srivastava, Vikrant Sudan, Shanker Kumar Singh, Soumen Choudhury, Daya Shanker
The present study was designed to assess the deleterious effects of bovine tropical theileriosis on the cardiovascular system and the consequent myocardial involvement in young calves. Myocardial effects in parasitic diseases are often neglected. Hemolytic anemia, associated secondary hypoxia, and vasculitis are cardinal features of bovine theileriosis. In the present study, electrocardiogram (ECG) alongside serum cardiac troponin I (cTnI) and creatinine phosphokinase-myocardial band (CPK-MB) concentrations were analyzed in infected, treated, and control groups of young calves...
February 17, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29455270/ventricular-tachycardia-triggered-by-loperamide-and-famotidine-abuse
#13
Timothy R Larsen, Jedediah McMunn, Hala Ahmad, Soufian T AlMahameed
A 32-year-old male developed recurrent ventricular tachycardia after taking mega doses of loperamide and famotidine in order to experience an opiate-like euphoric effect. He was taking up to 200 mg of loperamide and multiple doses of famotidine each day. He developed palpitations and syncope. Electrocardiography demonstrated ventricular tachycardia and QT interval prolongation (corrected QT interval was 597 ms). He was diagnosed with loperamide-induced QT prolongation resulting in incessant ventricular tachycardia...
February 17, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29454666/right-atrium-enlargement-predicts-clinically-significant-supraventricular-arrhythmia-in-patients-with-pulmonary-arterial-hypertension
#14
Marcin Waligóra, Anna Tyrka, Tomasz Miszalski-Jamka, Małgorzata Urbańczyk-Zawadzka, Piotr Podolec, Grzegorz Kopeć
BACKGROUND: Right atrial (RA) enlargement is a common finding in patients with pulmonary arterial hypertension (PAH) and an important predictor of mortality, however its relation to the risk of atrial arrhythmias has not been assessed. OBJECTIVES: To assess whether RA enlargement is associated with supraventricular arrhythmias (SVA) and whether it predicts new clinically significant SVA (csSVA). METHODS: Patients with PAH were recruited between January 2010 and December 2014 and followed until January 2017...
February 14, 2018: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/29454610/direct-and-indirect-effects-of-ephedrine-on-heart-rate-and-blood-pressure-in-vehicle-treated-and-sympathectomised-male-rats
#15
Hadeel A Alsufyani, James R Docherty
We have investigated the cardiac and pressor responses to (±)-ephedrine and (-)-ephedrine in pentobarbitone anaesthetised male wistar rats. The tachycardiac responses to (±)- and (-)-ephedrine were similar, but pressor responses to (-)-ephedrine (10mg/kg) were significantly greater than those to (±)-ephedrine, and for both, the pressor response was followed by a small depressor response. Sympathectomy did not affect pressor responses, but significantly increased the later depressor response to both compounds...
February 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29454137/mechanisms-and-management-of-refractory-ventricular-arrhythmias-in-the-age-of-autonomic-modulation
#16
Jason S Bradfield, Olujimi A Ajijola, Marmar Vaseghi, Kalyanam Shivkumar
Ventricular arrhythmias are responsible for hundreds of thousands of deaths every year. Catheter ablation of ventricular tachycardia (VT) is an essential component of the management of these life-threatening arrhythmias. However, in many patients, despite medical and interventional therapy, VT recurs. Further, some VT substrates (mid-myocardial, left ventricular summit, intra-septal) are not easily targeted, due to limitations of currently available technology. In certain clinical settings, ventricular fibrillation (VF) episodes that have premature ventricular contraction (PVC) triggers can also be targeted with catheter ablation...
February 14, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29453246/yield-of-the-ryr2-genetic-test-in-suspected-catecholaminergic-polymorphic-ventricular-tachycardia-and-implications-for-test-interpretation
#17
Jamie D Kapplinger, Krishna N Pundi, Nicholas B Larson, Thomas E Callis, David J Tester, Hennie Bikker, Arthur A M Wilde, Michael J Ackerman
BACKGROUND: Pathogenic RYR2 variants account for ≈60% of clinically definite cases of catecholaminergic polymorphic ventricular tachycardia. However, the rate of rare benign RYR2 variants identified in the general population remains a challenge for genetic test interpretation. Therefore, we examined the results of the RYR2 genetic test among patients referred for commercial genetic testing and examined factors impacting variant interpretability. METHODS: Frequency and location comparisons were made for RYR2 variants identified among 1355 total patients of varying clinical certainty and 60 706 Exome Aggregation Consortium controls...
February 2018: Circ Genom Precis Med
https://www.readbyqxmd.com/read/29452692/prognostic-significance-of-complex-ventricular-arrhythmias-complicating-st-segment-elevation-myocardial-infarction
#18
Tomasz Podolecki, Radoslaw Lenarczyk, Jacek Kowalczyk, Ewa Jedrzejczyk-Patej, Piotr Chodor, Michal Mazurek, Pawel Francuz, Witold Streb, Katarzyna Mitrega, Zbigniew Kalarus
The aim of the study was to assess the clinical significance of complex ventricular arrhythmias (VAs) (sustained ventricular tachycardia [sVT] and ventricular fibrillation [VF]) in patients with ST-segment elevation myocardial infarction (STEMI) depending on timing of arrhythmia. We analyzed 4,363 consecutive patients with STEMI treated invasively between 2004 and 2014. The median follow-up was 69.6 months (range: 0 to 139.8 months). The study population was divided into 2 main groups; VA group encompassed 476 patients (10...
January 12, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29452352/conditional-ablation-and-conditional-rescue-models-for-casq2-elucidate-the-role-of-development-and-of-cell-type-specific-expression-of-casq2-in-the-cpvt2-phenotype
#19
Daniel J Flores, ThuyVy Duong, Luke O Brandenberger, Apratim Mitra, Aditya Shirali, John C Johnson, Danielle Springer, Audrey Noguchi, Zu-Xi Yu, Steven N Ebert, Andreas Ludwig, Bjorn C Knollmann, Mark D Levin, Karl Pfeifer
Cardiac calsequestrin (Casq2) associates with the Ryanodine Receptor 2 channel in the junctional sarcoplasmic reticulum to regulate Ca2+ release into the cytoplasm. Patients carrying mutations in CASQ2 display low resting heart rates under basal conditions and stress-induced polymorphic ventricular tachycardia (CPVT). In this study we generate and characterize novel conditional deletion and conditional rescue mouse models to test the influence of developmental programs on the heart rate and CPVT phenotypes...
February 14, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29452255/radiofrequency-ablation-of-premature-ventricular-contractions-originating-from-uncommon-sites-of-right-ventricle
#20
Krishna Kumar Mohanan Nair, Narayanan Namboodiri, Arun Gopalakrishnan, Ajitkumar Valaparambil
Premature Ventricular Contraction (PVC)/ventricular tachycardia (VT) with left bundle branch block (LBBB) morphology and inferior axis has been described classically to originate from the right ventricular outflow tract (RVOT). Some uncommon sites of idiopathic ventricular arrhythmia (VA) origins have been revealed including tricuspid annulus (TA) and right ventricular (RV) inflow free wall region. We present a series of two cases who have undergone electrophysiological study and successful radiofrequency ablation of frequent monomorphic PVCs with LBBB pattern originating from relatively uncommon sites of RV - TA and RV inflow free wall region...
February 13, 2018: Indian Pacing and Electrophysiology Journal
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