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Chronic AND Spinal Cord Injury

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https://www.readbyqxmd.com/read/28812446/higher-dietary-intake-of-vitamin-d-may-influence-total-cholesterol-and-carbohydrate-profile-independent-of-body-composition-in-men-with-chronic-spinal-cord-injury
#1
Christopher Beal, Ashraf Gorgey, Pamela Moore, Nathan Wong, Robert A Adler, David Gater
STUDY DESIGN: A case-control design. OBJECTIVES: To determine the effects of dietary vitamin D intake on insulin sensitivity (Si), glucose effectiveness (Sg), and lipid profile in individuals with spinal cord injury (SCI). METHODS: 20 male, paraplegic (T3-L1) with chronic (> one year) motor complete SCI (AIS A or B) were recruited. Three-day dietary records were analyzed for dietary vitamin D (calciferol), and participants were assigned to one of two groups, a high vitamin D intake group and a low vitamin D intake group based on the mid-point of vitamin D frequency distribution...
August 16, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28810847/fev1-and-fvc-and-systemic-inflammation-in-a-spinal-cord-injury-cohort
#2
Jaime E Hart, Rebekah Goldstein, Palak Walia, Merilee Teylan, Antonio Lazzari, Carlos G Tun, Eric Garshick
BACKGROUND: Systemic inflammation has been associated with reduced pulmonary function in individuals with and without chronic medical conditions. Individuals with chronic spinal cord injury (SCI) have clinical characteristics that promote systemic inflammation and also have reduced pulmonary function. We sought to assess the associations between biomarkers of systemic inflammation with pulmonary function in a chronic SCI cohort, adjusting for other potential confounding factors. METHODS: Participants (n = 311) provided a blood sample, completed a respiratory health questionnaire, and underwent spirometry...
August 15, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28802811/effects-of-respiratory-training-on-heart-rate-variability-and-baroreflex-sensitivity-in-individuals-with-chronic-spinal-cord-injury
#3
Bonnie E Legg Ditterline, Sevda C Aslan, David C Randall, Susan J Harkema, Camilo Castillo, Alexander V Ovechkin
OBJECTIVE: To evaluate the effects of pressure threshold respiratory training (RT) on heart rate variability and baroreflex sensitivity in persons with chronic spinal cord injury (SCI). DESIGN: Before-after intervention case-controlled clinical study. SETTING: SCI research center and outpatient rehabilitation unit. PARTICIPANTS: Persons with chronic SCI ranging from C2 to T11 that participated in RT (n=24) and untrained chronic SCI controls ranging from C2 to T9 (n=20)...
August 9, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28801220/multiple-reflex-pathways-contribute-to-bladder-activation-by-intraurethral-stimulation-in-persons-with-spinal-cord-injury
#4
Meredith J McGee, Brandon D Swan, Zachary C Danziger, Cindy L Amundsen, Warren M Grill
OBJECTIVES: To measure the urodynamic effects of electrical co-stimulation of two individual sites in the proximal and distal urethra in persons with spinal cord injury (SCI). This work was motivated by preclinical findings that selective co-stimulation of the cranial urethral sensory nerve and the dorsal genital nerve, which innervate the proximal and distal portions of the urethra, respectively, increased reflex bladder activation and voiding efficiency. METHODS: Electrical co-stimulation of urethral afferents was conducted in persons with chronic SCI during urodynamics...
August 8, 2017: Urology
https://www.readbyqxmd.com/read/28800048/mental-practice-for-chronic-pain-in-people-with-spinal-cord-injury-a-systematic-review-protocol
#5
Emmanuelle Opsommer, Natalya Korogod
The primary objective of this systematic review is to identify the effects of mental practice (MP) interventions on chronic neuropathic and nociceptive pain and motor function recovery in individuals after spinal cord injury (SCI). Where possible, this review will also describe the optimal type and dosage (i.e. frequency, intensity and duration) of MP interventions for patients with SCI.
August 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28797584/long-term-outcomes-of-frozen-elephant-trunk-for-type-a-aortic-dissection-in-patients-with-marfan-syndrome
#6
Wei-Guo Ma, Wei Zhang, Jun-Ming Zhu, Bulat A Ziganshin, Ai-Hua Zhi, Jun Zheng, Yong-Min Liu, John A Elefteriades, Li-Zhong Sun
OBJECTIVE: The use of the frozen elephant trunk (FET) technique for repair of type A aortic dissection (TAAD) in Marfan syndrome (MFS) is controversial. We seek to evaluate the efficacy of FET and total arch replacement (TAR) for TAAD in patients with MFS. METHODS: The early and long-term outcomes were analyzed for 106 patients with MFS (mean age, 34.5 ± 9.7 years) undergoing FET + TAR for TAAD. RESULTS: Operative mortality was 6.6% (7 of 106)...
June 16, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28795657/body-system-effects-of-a-multi-modal-training-program-targeting-chronic-motor-complete-thoracic-spinal-cord-injury
#7
Katie Gant, Kathleen Nagle, Rachel Cowan, Edelle Field-Fote, Mark Nash, Jochen Kressler, Christine K Thomas, Mabelin Castellanos, Eva Widerstrom-Noga, Kimberly D Anderson
The safety and efficacy of pharmacologic and cellular transplantation strategies are currently being evaluated in people with spinal cord injury. In studies of people with chronic spinal cord injuries, it is thought that functional recovery will be best achieved when drug or cell therapies are combined with rehabilitation protocols. However, any functional recovery due to the therapy may be confounded by the conditioned state of the body and by training-induced effects on neuroplasticity. For this reason, we sought to investigate the effects of a multi-modal training program on several body systems...
August 10, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28793038/transplantation-of-human-immature-dental-pulp-stem-cell-in-dogs-with-chronic-spinal-cord-injury
#8
Matheus Levi Tajra Feitosa, Carlos Alberto Palmeira Sarmento, Renato Zonzini Bocabello, Patrícia Cristina Baleeiro Beltrão-Braga, Graciela Conceição Pignatari, Robson Fortes Giglio, Maria Angelica Miglino, Jéssica Rodrigues Orlandin, Carlos Eduardo Ambrósio
Purpose: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs. Methods: Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative. Results: There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation...
July 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28781920/delayed-presentation-of-spinal-foreign-body-case-report-and-review-of-literature
#9
Franz J Onishi, Mirto N Prandini, Sergio Cavalheiro
BACKGROUND: Although spinal cord injuries are frequent causes of myelopathy in young patients, stab wounds of the spinal cord rarely occur and are typically maximal symptomatic immediately after the trauma. CASE DESCRIPTION: A 31-year-old male developed delayed onset of symptoms 4 years after a stab wound to the cervical spinal cord attributed to a plant needle (plant called Mandacaru). Following removal of the foreign body and decompression/excision of scarring at the C34 level, the patient's symptoms resolved...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28781176/electrical-neuromodulation-of-the-respiratory-system-after-spinal-cord-injury
#10
REVIEW
Jan T Hachmann, Peter J Grahn, Jonathan S Calvert, Dina I Drubach, Kendall H Lee, Igor A Lavrov
Spinal cord injury (SCI) is a complex and devastating condition characterized by disruption of descending, ascending, and intrinsic spinal circuitry resulting in chronic neurologic deficits. In addition to limb and trunk sensorimotor deficits, SCI can impair autonomic neurocircuitry such as the motor networks that support respiration and cough. High cervical SCI can cause complete respiratory paralysis, and even lower cervical or thoracic lesions commonly result in partial respiratory impairment. Although electrophrenic respiration can restore ventilator-independent breathing in select candidates, only a small subset of affected individuals can benefit from this technology at this moment...
August 3, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28771534/neural-stem-cell-mediated-recovery-is-enhanced-by-chondroitinase-abc-pretreatment-in-chronic-cervical-spinal-cord-injury
#11
Hidenori Suzuki, Christopher S Ahuja, Ryan P Salewski, Lijun Li, Kajana Satkunendrarajah, Narihito Nagoshi, Shinsuke Shibata, Michael G Fehlings
Traumatic spinal cord injuries (SCIs) affect millions of people worldwide; the majority of whom are in the chronic phase of their injury. Unfortunately, most current treatments target the acute/subacute injury phase as the microenvironment of chronically injured cord consists of a well-established glial scar with inhibitory chondroitin sulfate proteoglycans (CSPGs) which acts as a potent barrier to regeneration. It has been shown that CSPGs can be degraded in vivo by intrathecal Chondroitinase ABC (ChABC) to produce a more permissive environment for regeneration by endogenous cells or transplanted neural stem cells (NSCs) in the subacute phase of injury...
2017: PloS One
https://www.readbyqxmd.com/read/28769815/heart-rate-variability-a-novel-modality-for-diagnosing-neuropathic-pain-after-spinal-cord-injury
#12
Jay Karri, Larry Zhang, Shengai Li, Yen-Ting Chen, Argyrios Stampas, Sheng Li
Background: Heart rate variability (HRV), the physiological variance in the heart's R-R interval length, can be analyzed to produce various parameters reflective of one's autonomic balance. HRV analysis may be used to capture those autonomic aberrations associated with chronic neuropathic pain (NP) in spinal cord injury (SCI). This study assesses the capacity of HRV parameters to diagnose NP in an SCI cohort. Methods: An electrocardiogram (ECG) was collected at rest from able bodied participants (AB, n = 15), participants with SCI only (SCI-NP, n = 11), and those with SCI and NP (SCI+NP, n = 20)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28769769/transplantation-of-hematopoietic-stem-cells-promotes-functional-improvement-associated-with-nt-3-mek-1-activation-in-spinal-cord-transected-rats
#13
Liu-Lin Xiong, Fei Liu, Shi-Kang Deng, Jia Liu, Qi-Qin Dan, Piao Zhang, Yu Zou, Qing-Jie Xia, Ting-Hua Wang
Transected spinal cord injury (SCT) is a devastating clinical disease that strongly affects a patient's daily life and remains a great challenge for clinicians. Stem-cell therapy has been proposed as a potential therapeutic modality for SCT. To investigate the effects of hematopoietic stem cells (HSCs) on the recovery of structure and function in SCT rats and to explore the mechanisms associated with recovery, 57 adult Sprague-Dawley rats were randomly divided into sham (n = 15), SCT (n = 24), and HSC transplantation groups (n = 15)...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28768745/altered-modulation-of-sensorimotor-rhythms-with-chronic-paralysis
#14
Stephen T Foldes, Douglas John Weber, Jennifer L Collinger
After paralysis, the disconnection between the cortex and its peripheral targets leads to neuroplasticity throughout the nervous system. However, it is unclear how chronic paralysis specifically impacts cortical oscillations associated with attempted movement of impaired limbs. We hypothesized that mu (8-13Hz) and beta (15-30Hz) event-related desynchronization (ERD) would be less modulated for individuals with hand paralysis due to cervical spinal cord injury (SCI). To test this, we compared the modulation of ERD from magnetoencephalography (MEG) during attempted and imagined grasping performed by participants with cervical SCI (n = 12) and able-bodied controls (n = 13)...
August 2, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28767631/neuroprotective-effects-of-c-terminal-domain-of-tetanus-toxin-on-rat-brain-against-motorneuron-damages-after-experimental-spinal-cord-injury
#15
Murat Celal Sozbilen, Murat Oztürk, Gizem Kaftan, Taner Dagci, Halit Ozyalcin, Güliz Armagan
STUDY DESIGN: Experimental animal study investigating the efficacy of C-terminal domain of tetanus toxin application as neuroprotective effects on rat brain in a model of spinal cord injury. OBJECTIVE: The aim of the present study was to investigate the possible role of C-terminal domain of tetanus toxin (Hc-TeTx) on cell death mechanisms including apoptosis and autophagy following SCI. SUMMARY OF BACKGROUND DATA: Traumatic spinal cord injury (SCI) can lead to post-traumatic inflammation, oxidative stress, motor neuron apoptosis, necrosis and autophagy of tissue...
August 1, 2017: Spine
https://www.readbyqxmd.com/read/28762876/constraints-on-stance-phase-force-production-during-overground-walking-in-persons-with-chronic-incomplete-spinal-cord-injury
#16
Denise M Peters, Yann Thibaudier, Joan Deffeyes, Gila Baer, Heather B Hayes, Randy D Trumbower
Persons with incomplete spinal cord injury (iSCI) face ongoing struggles with walking, including reduced speed and increased reliance on assistive devices (ADs). The forces underlying body weight support and gait, as measured by ground reaction forces (GRFs), are likely altered following iSCI due to weakness and AD dependence but have not been studied. The purpose of this study was to examine GRF production during overground walking after iSCI, as greater insight into GRF constraints is important for refining therapeutic interventions...
August 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28762383/clinical-factors-associated-with-c-reactive-protein-in-chronic-spinal-cord-injury
#17
R L Goldstein, P Walia, M Teylan, A A Lazzari, C G Tun, J E Hart, E Garshick
STUDY DESIGN: Cross-sectional study. OBJECTIVES: Determine clinical factors associated with plasma C-reactive protein (CRP) in persons with chronic spinal cord injury (SCI). SETTING: Veterans Affairs Medical Center in Boston, MA, USA. METHODS: Participants provided a blood sample, completed a respiratory health questionnaire and underwent dual X-ray absorptiometry (DXA) to assess total and regional body fat. Linear regression models were used to assess cross-sectional associations with plasma CRP...
August 1, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28762382/spontaneous-acute-and-chronic-spinal-cord-injuries-in-paraplegic-dogs-a-comparative-study-of-in-vivo-diffusion-tensor-imaging
#18
A Wang-Leandro, M K Hobert, N Alisauskaite, P Dziallas, K Rohn, V M Stein, A Tipold
STUDY DESIGN: Prospective observational-analytical study. OBJECTIVES: Description of diffusion tensor imaging (DTI) metrics obtained from the spinal cord (SC) of dogs with severe acute or chronic spontaneous, non-experimentally induced spinal cord injury (SCI) and correlation of DTI values with lesion extent of SCI measured in T2-weighted (T2W) magnetic resonance imaging sequences. SETTING: Hannover, Germany. METHODS: Forty-seven paraplegic dogs, 32 with acute and 15 with chronic SCI, and 6 disease controls were included...
August 1, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28760352/image-guided-percutaneous-intralesional-administration-of-mesenchymal-stromal-cells-in-subjects-with-chronic-complete-spinal-cord-injury-a-pilot-study
#19
Ticiana Ferreira Larocca, Carolina Thé Macêdo, Bruno Solano de Freitas Souza, Yuri M Andrade-Souza, Cristiane Flora Villarreal, André Costa Matos, Daniela Nascimento Silva, Kátia Nunes da Silva, Clarissa Lima E Moura de Souza, Daniela da Silva Paixão, Milena da Rocha Bezerra, Rodrigo Leal Alves, Milena Botelho Pereira Soares, Ricardo Ribeiro Dos Santos
BACKGROUND AIMS: The potential of cell therapies to improve neurological function in subjects with spinal cord injury (SCI) is currently under investigation. In this context, the choice of cell type, dose, route and administration regimen are key factors. Mesenchymal stromal cells (MSCs) can be easily obtained, expanded and are suitable for autologous transplantation. Here we conducted a pilot study that evaluated safety, feasibility and potential efficacy of intralesional MSCs transplantation performed through image-guided percutaneous injection, in subjects with chronic complete SCI...
July 28, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28758566/the-influence-of-level-of-spinal-cord-injury-on-adipose-tissue-and-its-relationship-to-inflammatory-adipokines-and-cardiometabolic-profiles
#20
Gary J Farkas, Ashraf S Gorgey, David R Dolbow, Arthur S Berg, David R Gater
OBJECTIVE: Level of injury (LOI) and the role of adipose tissue and its proinflammatory adipokines in cardiometabolic dysfunction following spinal cord injury (SCI) remains poorly understood. We aim to examine the influence of LOI on adipose tissue and its relationship to proinflammatory adipokines and cardiometabolic profiles following SCI. DESIGN: Cross sectional and correlational study. SETTING: Clinical hospital and academic setting. PARTICIPANTS: Forty-seven individuals with chronic motor complete SCI (age 43...
July 30, 2017: Journal of Spinal Cord Medicine
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