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Chronic AND Spinal Cord Injury

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https://www.readbyqxmd.com/read/27901476/the-change-of-hcn1-hcn2-mrna-expression-in-peripheral-nerve-after-chronic-constriction-injury-induced-neuropathy-followed-by-pulsed-electromagnetic-field-therapy
#1
Hui Liu, Jun Zhou, Lianbing Gu, Yunxia Zuo
Neuropathic pain is usually defined as a chronic pain state caused by peripheral or central nerve injury as a result of acute damage or systemic diseases. It remains a difficult disease to treat. Recent studies showed that the frequency of action potentials in nociceptive afferents is affected by the activity of hyperpolarization-activated cyclic nucleotide-gated cation channels (HCN) family. In the current study, we used a neuropathy rat model induced by chronic constriction injury (CCI) of sciatic nerve to evaluate the change of expression of HCN1/HCN2 mRNA in peripheral nerve and spinal cord...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901413/dose-response-outcomes-associated-with-different-forms-of-locomotor-training-in-persons-with-chronic-motor-incomplete-spinal-cord-injury
#2
Evan Blake Sandler, Kathryn E Roach, Edelle C Field-Fote
Outcomes of training are thought to be related to amount of training (training dose). While various approaches to locomotor training have been used to improve walking function in persons with spinal cord injury, little is known about the relationship between dose of locomotor training and walking outcomes. This secondary analysis aimed to identify the relationship between training dose and improvement in walking distance and speed associated with the largest randomized clinical trial to date of locomotor training in participants with chronic motor-incomplete spinal cord injury (MISCI)...
November 30, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27897186/managing-pain-and-fatigue-in-people-with-spinal-cord-injury-a-randomized-controlled-trial-feasibility-study-examining-the-efficacy-of-massage-therapy
#3
J Lovas, Y Tran, J Middleton, R Bartrop, N Moore, A Craig
STUDY DESIGN: A randomized controlled trial (RCT). OBJECTIVES: To determine the efficacy of massage therapy (MT) as a treatment that could be implemented to reduce pain and fatigue in people with chronic spinal cord injury (SCI). SETTING: Laboratory setting in Sydney, Australia. METHODS: Participants included 40 people with SCI living in the community who were randomly assigned into one of two RCT arms: MT (Swedish massage to upper body) or an active concurrent control (guided imagery (GI) relaxation)...
November 29, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27896922/-epigallocatechin-3-gallate-antihyperalgesic-effect-associates-with-reduced-cx3cl1-chemokine-expression-in-spinal-cord
#4
Marc Bosch-Mola, Judit Homs, Beltrán Álvarez-Pérez, Teresa Puig, Francisco Reina, Enrique Verdú, Pere Boadas-Vaello
(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the neuropathic pain alleviation in animal models. Because chemokine fractalkine (CX3CL1) has been suggested as an important signal during neuropathic pain development, this study aimed to investigate whether CX3CL1 expression may be modulated by EGCG treatment reducing hyperalgesia in chronic constriction injured mice. To this end, Balb/c mice were subjected to a chronic constriction injury of sciatic nerve (CCI) and treated with EGCG or vehicle once a day during the first week following surgery...
November 29, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27896143/new-avenues-for-reducing-intensive-care-needs-in-patients-with-chronic-spinal-cord-injury
#5
EDITORIAL
Pierre A Guertin
Relatively soon after their accident, patients suffering a spinal cord injury (SCI) begin generally experiencing the development of significant, often life-threatening secondary complications. Many of which are associated with chronic physical inactivity-related immune function problems and increasing susceptibility to infection that repeatedly requires intensive care treatment. Therapies capable of repairing the spinal cord or restoring ambulation would normally prevent many of these problems but, as of now, there is no cure for SCI...
November 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27895138/urotensin-ii-inhibitor-eases-neuropathic-pain-by-suppressing-the-jnk-nf-%C3%AE%C2%BAb-pathway
#6
Jing Li, Pan-Pan Zhao, Ting Hao, Dan Wang, Yu Wang, Yang-Zi Zhu, Yu-Qing Wu, Cheng-Hua Zhou
Urotensin II (U-II), a cyclic peptide originally isolated from the caudal neurosecretory system of fishes, can produce proinflammatory effects through its specific G protein-coupled receptor, GPR14. Neuropathic pain, a devastating disease, is related to excessive inflammation in the spinal dorsal horn. However, the relationship between U-II and neuropathic pain has not been reported. This study was designed to investigate the effect of U-II antagonist on neuropathic pain and to understand the associated mechanisms...
February 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/27894923/therapeutic-implications-of-toll-like-receptors-in-peripheral-neuropathic-pain
#7
REVIEW
Krishan K Thakur, Jyoti Saini, Kanika Mahajan, Dhyanendra Singh, Dinkar P Jaiswal, Srishti Mishra, Anupam Bishyaee, Gautam Sethi, Ajaikumar B Kunnumakkara
Neuropathic pain is a state of chronic pain arising after peripheral or central nerve injury. These injuries can be mediated through the activation of various cells (astrocytes, microglia and Schwann cells), as well as the dissolution of distal axons. Recent studies have suggested that after nerve injury, Toll-like receptors (TLRs) are involved in Wallerian degeneration and generation of neuropathic pain. Furthermore, these TLRs are responsible for the stimulation of astrocytes and microglia that can cause induction of the proinflammatory mediators and cytokines in the spinal cord, thereby leading to the generation and maintenance of neuropathic pain...
November 25, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27894730/living-with-chronic-pain-after-spinal-cord-injury-a-mixed-methods-study
#8
Eva Widerström-Noga, Kimberly D Anderson, Salomé Perez, Judith P Hunter, Alberto Martinez-Arizala, James P Adcock, Maydelis Escalona
OBJECTIVE: To identify the relative importance of positive (facilitators) and negative (barriers) contributors to living with chronic pain after spinal cord injury (SCI). DESIGN: Mixed-methods: (1) Qualitative: Individual semi-structured, open-ended interviews identifying facilitator/barrier themes; (2) Quantitative: Converting the most common themes into statements and quantifying agreement with these in an online survey to determine relative importance, underlying dimensions and their associations with perceived difficulty in dealing with pain...
November 25, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27892796/using-a-divided-attention-stepping-accuracy-task-to-improve-balance-and-functional-outcomes-in-an-individual-with-incomplete-spinal-cord-injury-a-case-report
#9
Susan J Leach, Richard A Magill, Joyce R Maring
A spinal cord injury (SCI) frequently results in impaired balance, endurance, and strength with subsequent limitations in functional mobility and community participation. The purpose of this case report was to implement a training program for an individual with a chronic incomplete SCI using a novel divided-attention stepping accuracy task (DASAT) to determine if improvements could be made in impairments, activities, and participation. The client was a 51-year-old male with a motor incomplete C4 SCI sustained 4 years prior...
November 28, 2016: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/27889808/pharmacodynamic-evaluation-of-lys-5-meleu-9-nle-10-nka-4-10-prokinetic-effects-on-bladder-and-colon-activity-in-acute-spinal-cord-transected-and-spinally-intact-rats
#10
F Aura Kullmann, M Katofiasc, K B Thor, Lesley Marson
The purpose of this study was to determine feasibility of a novel therapeutic approach to drug-induced voiding after spinal cord injury (SCI) using a well-characterized, peptide, neurokinin 2 receptor (NK2 receptor) agonist, Lys(5), MeLeu(9), Nle(10)-NKA(4-10) (LMN-NKA). Cystometry and colorectal pressure measurements were performed in urethane-anesthetized, intact, and acutely spinalized female rats. Bladder pressure and voiding were monitored in response to intravenous LMN-NKA given with the bladder filled to 70% capacity...
November 26, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27875927/what-is-being-trained-how-divergent-forms-of-plasticity-compete-to-shape-locomotor-recovery-after-spinal-cord-injury
#11
J Russell Huie, Kazuhito Morioka, Jenny Haefeli, Adam R Ferguson
Spinal cord injury (SCI) is a devastating syndrome that produces dysfunction in motor and sensory systems, manifesting as chronic paralysis, sensory changes, and pain disorders. The multifaceted and heterogeneous nature of SCI has made effective rehabilitative strategies challenging. Work over the last 40 years has aimed to overcome these obstacles by harnessing the intrinsic plasticity of the spinal cord to improve functional locomotor recovery. Intensive training after SCI facilitates lower extremity function and has shown promise as a tool for retraining the spinal cord by engaging innate locomotor circuitry in the lumbar cord...
November 22, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27871967/prevalence-and-etiology-of-hypogonadism-in-young-men-with-chronic-spinal-cord-injury-a-cross-sectional-analysis-from-two-university-based-rehabilitation-centers
#12
Shannon D Sullivan, Mark S Nash, Eshetu Tefera, Emily Tinsley, Marc R Blackman, Suzanne Groah
BACKGROUND: Spinal cord injury (SCI) triggers an 'accelerated aging' process that may include development of hypogonadism, even among younger men with SCI; however, few studies have investigated the prevalence or etiology of hypogonadism in men with SCI. Young men with SCI are also at increased risk for developing metabolic dysfunction after injury, which may be exacerbated by concomitant testosterone (T) deficiency, thus identifying the prevalence and risk factors for T deficiency in men with SCI is important for their long-term health...
November 18, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27871577/lack-of-electrical-interference-between-spinal-cord-stimulators-and-other-implanted-electrical-pulse-devices
#13
Alaa Abd-Elsayed, Ravi Grandhi, Harsh Sachdeva
Spinal cord stimulators (SCSs) have been used for decades to treat chronic pain. SCSs are often used to treat patients with chronic back pain caused by failed back surgery syndrome, patients with complex regional pain syndrome, or individuals who are not candidates for surgery. SCSs are a relative contraindication in patients with another electrical pulse device. We present 3 patients who received SCS despite having another implant in place. There was no interaction between devices. The first case was a patient with failed back surgery syndrome who had an implantable cardiac defibrillator and an SCS implant...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27866246/comparison-of-self-efficacy-for-managing-chronic-disease-between-patients-with-systemic-sclerosis-and-other-chronic-conditions-a-systematic-review
#14
Brett D Thombs, Linda Kwakkenbos, Kira E Riehm, Nazanin Saadat, Claire Fedoruk
The complexity and burden of systemic sclerosis (SSc) pose challenges to developing and sustaining disease management self-efficacy. The objective of this systematic review was to compare scores on a commonly used self-efficacy measure, the Self-Efficacy for Managing Chronic Disease (SEMCD) Scale, between SSc and other diseases. Data sources included the CINAHL, EMBASE, MEDLINE, and Scopus databases, searched through January 25, 2016, and reference lists of included articles and relevant reviews. Studies in any language that reported total SEMCD scores or individual item scores in adult non-psychiatric medical patients were eligible...
November 19, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27863083/promotion-of-neurological-recovery-in-rat-spinal-cord-injury-by-mesenchymal-stem-cells-loaded-on-nerve-guided-collagen-scaffold-through-increasing-alternatively-activated-macrophage-polarization
#15
Zhan Peng, Wei Gao, Bing Yue, Jie Jiang, Yong Gu, Jianwu Dai, Liang Chen, Qin Shi
Mesenchymal stem cells(MSCs)characterized by multi-differentiation potent and immunoregulatory have been used in the treatment of spinal cord injury (SCI), but the direct transplantation may limit its effectiveness due to quick diffusion. In addition, the role of macrophages in healing is being increasingly recognized because of the ability to polarize into pro- and anti-inflammatory phenotypes. In the present study, we developed the nerve-guide collagen scaffold (CS) and rat MSCs. After CS was confirmed to minimize MSCs distribution in vivo by the positron emission tomography (PET) imaging, the repair capacity of combined implantation of CS and MSCs and the effect on classically activated macrophage (M1)/alternatively activated macrophage (M2) polarization was assessed in a hemisected SCI rat model...
November 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27857906/current-concept-of-stem-cell-therapy-for-spinal-cord-injury-a-review
#16
REVIEW
Sun Kyu Oh, Sang Ryong Jeon
Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological deficit, social, and financial burdens. Over the past decades, various treatments including medication, surgery, and rehabilitation therapy for SCI have been performed, but there were no definite treatment option to improve neurological function of patients with chronic SCI. Therefore, new treatment trials with stem cells have been studied to regenerate injured spinal cord. Among various types of stem cells, bone marrow derived mesenchymal stem cells is highly expected as candidates for the stem cell therapy...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27857741/future-directions-for-using-estrogen-receptor-agonists-in-the-treatment-of-acute-and-chronic-spinal-cord-injury
#17
Swapan K Ray, Supriti Samntaray, Naren L Banik
No abstract text is available yet for this article.
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27856613/dorsal-horn-interneuron-derived-netrin-4-contributes-to-spinal-sensitization-in-chronic-pain-via-unc5b
#18
Yasufumi Hayano, Keiko Takasu, Yoshihisa Koyama, Moe Yamada, Koichi Ogawa, Kazuhisa Minami, Toshiyuki Asaki, Kazuhiro Kitada, Satoshi Kuwabara, Toshihide Yamashita
Because of the incomplete understanding of the molecular mechanisms that underlie chronic pain, the currently available treatments for this type of pain remain inefficient. In this study, we show that Netrin-4, a member of the axon guidance molecule family, was expressed in dorsal horn inner lamina II excitatory interneurons in the rat spinal cord. A similar expression pattern for Netrin-4 was also observed in human spinal cord. Behavioral analysis revealed that tactile and heat hyperalgesia after peripheral nerve injury or inflammation were abolished in Netrin-4-mutant rats...
November 17, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27855706/human-class-i-major-histocompatibility-complex-alleles-determine-central-nervous-system-injury-versus-repair
#19
Bharath Wootla, Aleksandar Denic, Jens O Watzlawik, Arthur E Warrington, Laurie J Zoecklein, Louisa M Papke-Norton, Chella David, Moses Rodriguez
BACKGROUND: We investigated the role of human HLA class I molecules in persistent central nervous system (CNS) injury versus repair following virus infection of the CNS. METHODS: Human class I A11(+) and B27(+) transgenic human beta-2 microglobulin positive (Hβ2m(+)) mice of the H-2 (b) background were generated on a combined class I-deficient (mouse beta-2 microglobulin deficient, β2m(0)) and class II-deficient (mouse Aβ(0)) phenotype. Intracranial infection with Theiler's murine encephalomyelitis virus (TMEV) in susceptible SJL mice results in acute encephalitis with prominent injury in the hippocampus, striatum, and cortex...
November 17, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27853668/the-effectiveness-and-safety-of-exoskeletons-as-assistive-and-rehabilitation-devices-in-the-treatment-of-neurologic-gait-disorders-in-patients-with-spinal-cord-injury-a-systematic-review
#20
Christian Fisahn, Mirko Aach, Oliver Jansen, Marc Moisi, Angeli Mayadev, Krystle T Pagarigan, Joseph R Dettori, Thomas A Schildhauer
Study Design Systematic review. Clinical Questions (1) When used as an assistive device, do wearable exoskeletons improve lower extremity function or gait compared with knee-ankle-foot orthoses (KAFOs) in patients with complete or incomplete spinal cord injury? (2) When used as a rehabilitation device, do wearable exoskeletons improve lower extremity function or gait compared with other rehabilitation strategies in patients with complete or incomplete spinal cord injury? (3) When used as an assistive or rehabilitation device, are wearable exoskeletons safe compared with KAFO for assistance or other rehabilitation strategies for rehabilitation in patients with complete or incomplete spinal cord injury? Methods PubMed, Cochrane, and Embase databases and reference lists of key articles were searched from database inception to May 2, 2016, to identify studies evaluating the effectiveness of wearable exoskeletons used as assistive or rehabilitative devices in patients with incomplete or complete spinal cord injury...
December 2016: Global Spine Journal
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