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Chronic AND Spinal Cord Injury

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https://www.readbyqxmd.com/read/29774780/increased-levels-of-circulating-gfap-and-crmp2-autoantibodies-in-the-acute-stage-of-spinal-cord-injury-predict-the-subsequent-development-of-neuropathic-pain
#1
Georgene W Hergenroeder, John B Redell, Huimahn Alex Choi, Lisa Hollan Schmitt, William Donovan, Gerard E Francisco, Karl M Schmitt, Anthony N Moore, Pramod K Dash
Neuropathic pain develops in 40-70% of spinal cord injury (SCI) patients and markedly compromises quality of life. We examined plasma from SCI patients for autoantibodies to glial fibrillary acidic protein (GFAP) and collapsin response mediator protein-2 (CRMP2) and evaluated their relationship to the development of neuropathic pain. In study 1, plasma samples and clinical data from 80 chronic SCI patients (1-41 years post-SCI) were collected and screened for GFAP autoantibodies (GFAPab). Results from study 1 indicated that GFAPab were present in 34 of 80 (42...
May 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29770147/koumine-attenuates-neuroglia-activation-and-inflammatory-response-to-neuropathic-pain
#2
Gui-Lin Jin, Sai-Di He, Shao-Mei Lin, Li-Mian Hong, Wan-Qing Chen, Ying Xu, Jian Yang, Su-Ping Li, Chang-Xi Yu
Despite decades of studies, the currently available drugs largely fail to control neuropathic pain. Koumine-an alkaloidal constituent derived from the medicinal plant Gelsemium elegans Benth.-has been shown to possess analgesic and anti-inflammatory properties; however, the underlying mechanisms remain unclear. In this study, we aimed to investigate the analgesic and anti-inflammatory effects and the possible underlying mechanisms of koumine. The analgesic and anti-inflammatory effects of koumine were explored by using chronic constriction injury of the sciatic nerve (CCI) neuropathic pain model in vivo and LPS-induced injury in microglia BV2 cells in vitro ...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29763654/obturator-neuromodulation-with-laparoscopic-placement-of-an-obturator-lead-for-the-treatment-of-intractable-opioid-dependent-chronic-pelvic-pain-due-to-obturator-neuralgia
#3
Richard P Marvel
Chronic pelvic pain(CPP) is a common condition in women that can have a devastating effect on quality of life. Some of the most severe forms of CPP are related to peripheral nerve injuries causing persistent neuropathic pain. This is a case of a young woman with severe opioid dependent chronic pelvic and right groin pain due to obturator neuralgia. She had failed a multitude of treatments including multiple medications, manual physical therapy, nerve blocks, surgical neurolysis and spinal cord stimulation without significant benefit...
May 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29760484/top-down-descending-facilitation-of-spinal-sensory-excitatory-transmission-from-the-anterior-cingulate-cortex
#4
Tao Chen, Wataru Taniguchi, Qi-Yu Chen, Hidetoshi Tozaki-Saitoh, Qian Song, Ren-Hao Liu, Kohei Koga, Tsuyoshi Matsuda, Yae Kaito-Sugimura, Jian Wang, Zhi-Hua Li, Ya-Cheng Lu, Kazuhide Inoue, Makoto Tsuda, Yun-Qing Li, Terumasa Nakatsuka, Min Zhuo
Spinal sensory transmission is under descending biphasic modulation, and descending facilitation is believed to contribute to chronic pain. Descending modulation from the brainstem rostral ventromedial medulla (RVM) has been the most studied, whereas little is known about direct corticospinal modulation. Here, we found that stimulation in the anterior cingulate cortex (ACC) potentiated spinal excitatory synaptic transmission and this modulation is independent of the RVM. Peripheral nerve injury enhanced the spinal synaptic transmission and occluded the ACC-spinal cord facilitation...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29753649/comparison-of-subacute-and-chronic-scar-tissues-after-complete-spinal-cord-transection
#5
Xing Li, Bin Yang, Zhifeng Xiao, Yannan Zhao, Sufang Han, Yanyun Yin, Bing Chen, Jianwu Dai
Traditional views consider scar tissue formed in the lesion epicenter after severe spinal cord injury (SCI) as both a physical barrier and chemical impediment for axonal regeneration. Recently, a controversial opinion suggested that astrocyte scar formation aids rather than prevents axonal regeneration in the CNS. Here, following complete transection of the thoracic spinal cord (T8) in rats, we found that scar tissue showed greater growth factor expression at 2 weeks than 8 weeks post-SCI. Further, tandem mass tag (TMT)-based quantitative proteomic analysis revealed that the components of scar tissue formed in the subacute phase are quite different from that formed in the chronic phase...
May 10, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29752910/describing-functioning-in-people-living-with-spinal-cord-injury-in-switzerland-a-graphical-modelling-approach
#6
Cristina Ehrmann, Birgit Prodinger, Hans Peter Gmünder, Kerstin Hug, Jerome E Bickenbach, Gerold Stucki
OBJECTIVE: To describe functioning in people living with spinal cord injury (SCI) in Switzerland. DESIGN: Secondary analysis of cross-sectional survey data. SETTING: Community, Switzerland. PARTICIPANTS: Individuals (N=1549) who were 16 years or older with a history of traumatic or non-traumatic SCI and have a permanent residence in Switzerland. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Functioning was operationalized through four domains: impairments in body functions (measured with the SCI Secondary Conditions Scale); mental functions (Mental Health sub-scale of the SF-36); independence in performing activities (SCI Independence Measure Self-Report); performance problems in participation (Utrecht Scale for Evaluation Rehabilitation-Participation)...
May 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29752739/filter-probe-diffusion-imaging-improves-spinal-cord-injury-outcome-prediction
#7
Nathan P Skinner, Seung-Yi Lee, Shekar N Kurpad, Brian D Schmit, L Tugan Muftuler, Matthew D Budde
OBJECTIVE: Diffusion weighted imaging (DWI) is a powerful tool for investigating spinal cord injury (SCI), but has limited specificity for axonal damage- the most predictive feature of long-term functional outcome. In this study, a technique designed to detect acute axonal injury, filter-probe double diffusion encoding (FP-DDE) is compared with standard DWI for predicting long-term functional and cellular outcomes. METHODS: This study extends FP-DDE to predict long-term functional and histological outcomes in a rat SCI model of varying severities(n=58)...
May 11, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29750900/robot-guided-neuronavigated-repetitive-transcranial-magnetic-stimulation-rtms-in-central-neuropathic-pain-an-update-of-long-term-follow-up
#8
Charles Quesada, Benjamin Pommier, Camille Fauchon, Claire Bradley, Christelle Créac'h, François Vassal, Roland Peyron
OBJECTIVE: To confirm and extend previous results involving repetitive transcranial magnetic stimulation (rTMS) aimed at alleviating refractory central neuropathic pain(CNP). To evaluate pain relief in detail and to assess ongoing benefits after one year of treatment. DESIGN: Prospective observational study. SETTING: University hospital. Outpatient settings. PARTICIPANTS: 80 patients with chronic central pain after brain or spinal cord injuries...
May 8, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29749521/ephrinb-ephb-signaling-contributes-to-spinal-nociceptive-processing-via-calpain%C3%A2-1-and-caspase%C3%A2-3
#9
Mei Yang, Wei Chen, Yu Zhang, Rui Yang, Yiru Wang, Hongbin Yuan
Previous studies have indicated that an important subfamily of receptor tyrosine kinases, ephrins and their receptors, are important in pain signaling, particularly in spinal nociceptive processing. In the present study, the role of the ephrin/Eph signaling pathway was confirmed, and it was shown that this signaling was also involved in spinal nociceptive processing through the actions of calpain‑1 and caspase‑3. First, the ephrinB ligands, ephrinB1‑Fc or ephrinB2‑Fc, were introduced into experimental mice via intrathecal injection, and it was found that this injection induced marked time‑ and dose‑dependent mechanical allodynia and thermal hyperalgesia, accompanied by increased levels of calpain‑1 and caspase‑3 in the spinal cord...
May 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29746465/the-cybathlon-bci-race-successful-longitudinal-mutual-learning-with-two-tetraplegic-users
#10
Serafeim Perdikis, Luca Tonin, Sareh Saeedi, Christoph Schneider, José Del R Millán
This work aims at corroborating the importance and efficacy of mutual learning in motor imagery (MI) brain-computer interface (BCI) by leveraging the insights obtained through our participation in the BCI race of the Cybathlon event. We hypothesized that, contrary to the popular trend of focusing mostly on the machine learning aspects of MI BCI training, a comprehensive mutual learning methodology that reinstates the three learning pillars (at the machine, subject, and application level) as equally significant could lead to a BCI-user symbiotic system able to succeed in real-world scenarios such as the Cybathlon event...
May 2018: PLoS Biology
https://www.readbyqxmd.com/read/29736262/feasibility-of-robotic-exoskeleton-ambulation-in-a-c4-person-with-incomplete-spinal-cord-injury-a-case-report
#11
Robert M Lester, Ashraf S Gorgey
Introduction: To determine whether an individual with C4 incomplete spinal cord injury (SCI) with limited hand functions can effectively operate a powered exoskeleton (Ekso) to improve parameters of physical activity as determined by swing-time, up-time, walk-time, and total number of steps. Case presentation: A 21-year-old male with incomplete chronic (>1 year postinjury) SCI C4, participated in a clinical exoskeleton program to determine the feasibility of standing up and walking with limited hand functions...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29735608/diagnostic-accuracy-of-a-two-stage-model-for-detecting-obstructive-sleep-apnoea-in-chronic-tetraplegia
#12
Marnie Graco, Rachel Schembri, Susan Cross, Chinnaya Thiyagarajan, Shirin Shafazand, Najib T Ayas, Mark S Nash, Viet H Vu, Warren R Ruehland, Ching Li Chai-Coetzer, Peter Rochford, Thomas Churchward, Sally E Green, David J Berlowitz
BACKGROUND: Obstructive sleep apnoea (OSA) is highly prevalent in people with spinal cord injury (SCI). Polysomnography (PSG) is the gold-standard diagnostic test for OSA, however PSG is expensive and frequently inaccessible, especially in SCI. A two-stage model, incorporating a questionnaire followed by oximetry, has been found to accurately detect moderate to severe OSA (MS-OSA) in a non-disabled primary care population. This study investigated the accuracy of the two-stage model in chronic tetraplegia using both the original model and a modified version for tetraplegia...
May 7, 2018: Thorax
https://www.readbyqxmd.com/read/29733775/what-determines-low-satisfaction-with-life-in-individuals-with-spinal-cord-injury
#13
Sherri L LaVela, Bella Etingen, Scott Miskevics, Allen W Heinemann
OBJECTIVE: To examine variables associated with satisfaction with life (SWL) in individuals with a spinal cord injury (SCI). DESIGN: Cross-sectional, national survey to assess SWL, demographic and injury characteristics, health care utilization, chronic conditions (obesity, diabetes, heart problems, lung problems, hypertension, high cholesterol), symptoms (poor sleep, pain, depression), social support, grief/loss, and independence. SETTING/PARTICIPANTS: Community-dwelling Veterans with SCI...
May 7, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29729248/stimulation-dependent-remodeling-of-the-corticospinal-tract-requires-reactivation-of-growth-promoting-developmental-signaling-pathways
#14
Neela Zareen, Shahid Dodson, Kristine Armada, Rahma Awad, Nadia Sultana, Erina Hara, Heather Alexander, John H Martin
The corticospinal tract (CST) can become damaged after spinal cord injury or stroke, resulting in weakness or paralysis. Repair of the damaged CST is limited because mature CST axons fail to regenerate, which is partly because the intrinsic axon growth capacity is downregulated in maturity. Whereas CST axons sprout after injury, this is insufficient to recover lost functions. Chronic motor cortex (MCX) electrical stimulation is a neuromodulatory strategy to promote CST axon sprouting, leading to functional recovery after CST lesion...
May 2, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29729247/ionic-plasticity-and-pain-the-loss-of-descending-serotonergic-fibers-after-spinal-cord-injury-transforms-how-gaba-affects-pain
#15
Yung-Jen Huang, James W Grau
Activation of pain (nociceptive) fibers can sensitize neural circuits within the spinal cord, inducing an increase in excitability (central sensitization) that can foster chronic pain. The development of spinally-mediated central sensitization is regulated by descending fibers and GABAergic interneurons. In adult animals, the co-transporter KCC2 maintains a low intracellular concentration of the anion Cl- . As a result, when the GABA-A receptor is engaged, Cl- flows in the neuron which has a hyperpolarizing (inhibitory) effect...
May 2, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29729005/can-the-positive-association-of-osteocalcin-with-testosterone-be-unmasked-when-the-preeminent-hypothalamic-pituitary-regulation-of-testosterone-production-is-impaired-the-model-of-spinal-cord-injury
#16
A Barbonetti, S D'Andrea, J Samavat, A Martorella, G Felzani, S Francavilla, M Luconi, F Francavilla
PURPOSE: Osteocalcin (OCN), released from the bone matrix during the resorption phase, in its undercarboxylated form, stimulates testosterone (T) biosynthesis in mouse and a loss-of-function mutation of its receptor was associated with hypergonadotropic hypogonadism in humans. Nevertheless, when population-based studies have explored the OCN-T association, conflicting results have been reported. Hypothesizing that the evidence of a positive association between OCN and T could have been hindered by the preeminent role of a well-functioning hypothalamus-pituitary axis in promoting T biosynthesis, we explored this association in men with chronic spinal cord injury (SCI), exhibiting high prevalence of non-hypergonadotropic androgen deficiency...
May 4, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29715578/leisure-time-physical-activity-of-people-with-chronic-spinal-cord-injuries
#17
Katarzyna Kaźmierczak, Przemysław Lisiński
OBJECTIVE: The aim of this study was to evaluate the nature of LTPA performed by patients with incomplete spinal cord injury a minimum of 12 months after injury. Therefore, the study investigates the impact of injury location on the form and frequency of LTPA, time between injury and commencement of LTPA, motivations to undertake such physical activity, as well as factors which reduce participation. PATIENT AND METHODS: The study included 75 patients aged 18-60...
April 24, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29707239/falls-mobility-and-physical-activity-after-spinal-cord-injury-an-exploratory-study-using-photo-elicitation-interviewing
#18
Kristin E Musselman, Catherine Arnold, Clara Pujol, Kaylea Lynd, Sarah Oosman
Study design: Exploratory qualitative study using photo-elicitation interviews. Objectives: To identify contributors to falls, as perceived by individuals with incomplete spinal cord injury, and describe the impact of perceived fall risk on mobility and physical activity. Setting: Participants' home and community environments. Methods: Eight individuals with chronic motor incomplete spinal cord injury participated. Participants took photographs of situations that increased/decreased their risk of falling, or depicted how this risk impacted mobility and physical activity...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29706761/effects-of-spinal-cord-injury-in-heart-rate-variability-after-acute-and-chronic-exercise-a-systematic-review
#19
Daniel Bueno Buker, Cristóbal Castillo Oyarce, Raúl Smith Plaza
Background: Spinal cord injury (SCI) above T6 is followed by a loss of sympathetic supraspinal control of the heart, disturbing the autonomic balance and increasing cardiovascular risk. Heart rate variability (HRV) is a widely used tool for assessing the cardiac autonomic nervous system and positive adaptations after regular exercise in able-bodied subjects. However, adaptations in SCI subjects are not well known. Objectives: To compare HRV between able-bodied and SCI subjects and analyze the effects of chronic and acute exercise on HRV in the SCI group...
2018: Topics in Spinal Cord Injury Rehabilitation
https://www.readbyqxmd.com/read/29706124/sensorimotor-activity-partially-ameliorates-pain-and-reduces-nociceptive-fiber-density-in-the-chronically-injured-spinal-cord
#20
Christopher Sliwinski, Timo A Nees, Radhika Puttagunta, Norbert Weidner, Armin Blesch
A large proportion of patients suffering from spinal cord injury (SCI) develop chronic central neuropathic pain. Previously, we and others have shown that sensorimotor training early after SCI can prevent the development of mechanical allodynia. To determine whether training initiated in the subchronic/chronic phase remains effective, correlates of below level neuropathic pain were analyzed in the hindpaws 5-10 weeks after a moderate T11 contusion SCI (50 kDyn) in adult female C57BL/6 mice. Comparing SCI and sham mice 5 weeks post-injury, about 80% of injured animals developed mechanical hypersensitivity to light mechanical stimuli, whereas testing of noxious stimuli revealed hypo-responsiveness...
April 28, 2018: Journal of Neurotrauma
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