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Chronic AND Spinal Cord Injury

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https://www.readbyqxmd.com/read/28929919/evaluating-the-efficacy-of-functional-electrical-stimulation-therapy-assisted-walking-after-chronic-motor-incomplete-spinal-cord-injury-effects-on-bone-biomarkers-and-bone-strength
#1
B Catharine Craven, Lora M Giangregorio, S Mohammad Alavinia, Lindsie A Blencowe, Naaz Desai, Sander L Hitzig, Kei Masani, Milos R Popovic
To determine the efficacy of functional electrical stimulation therapy assisted walking (FES-T) compared to a conventional aerobic and resistance training (CONV) with respect to bone biomarkers and lower extremity bone strength outcomes among adults with chronic motor incomplete spinal cord injury (SCI). Design Parallel group randomized controlled trial ( www.clinicaltrials.gov - NCT0020196819). Site Tertiary academic rehabilitation centre in Canada. Methods Adults with chronic (≥18 months) motor incomplete SCI (C2-T12 AIS C-D) were consented and randomized to FES-T or CONV training for 45 minutes thrice-weekly for 4 months...
September 20, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28929907/management-of-obesity-after-spinal-cord-injury-a-systematic-review
#2
M H Shojaei, S M Alaviniaa, B C Craven
CONTEXT: Individuals with chronic spinal cord injury (SCI) are susceptible to central and visceral obesity and it's metabolic consequences; consensus based guidelines for obesity management after SCI have not yet been stablished. OBJECTIVES: To identify and compare effective means of obesity management among SCI individuals. METHODS: This systematic review included English and non-English articles, published prior to April 2017 found in the PubMed/Medline, Embase, CINAHL Psychinfo and Cochrane databases...
September 20, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28929471/-delta-9-tetrahydrocannabinol-cannabidiol-in-the-treatment-of-spasticity-in-chronic-spinal-cord-injury-a-clinical-experience
#3
C Grao-Castellote, F Torralba-Collados, L M Gonzalez, M Giner-Pascual
INTRODUCTION: Spasticity in chronic spinal cord injury is a condition that can have negative repercussions on the patient's quality of life. Its treatment is complex and sometimes the outcome is insufficient. Cannabinoids have recently been used in multiple sclerosis to successfully treat spasticity that is refractory to other therapies. AIM: To quantify the clinical response of a group of patients with spastic chronic spinal cord injury to the orally administered drug delta-9-tetrahydrocannabinol-cannabidiol (Sativex ®) as medication for use in special situations...
October 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28928629/proteomic-identification-of-an-upregulated-isoform-of-annexin-a3-in-the-spinal-cords-of-rats-in-a-neuropathic-pain-model
#4
Wangyuan Zou, Wei Xu, Zongbin Song, Tao Zhong, Yingqi Weng, Changsheng Huang, Maoyu Li, Chuanlei Zhang, Xianquan Zhan, Qulian Guo
Neuropathic pain (NP) is induced by nerve damage or a disturbance in the peripheral or central nervous systems. Nerve damage causes the activation of sensitizing mechanisms in the peripheral and central nervous systems, which induces transcriptional and post-transcriptional alterations in sensory nerves. However, the underlying mechanisms of NP remain elusive. In the study, Two-dimensional gel electrophoresis (2DGE)-based comparative proteomics identified 38 differential gel spots, and 15 differentially expressed proteins (DEPs) between the sham and the chronic constriction injury (CCI)-induced neuropathic pain rats...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28927908/the-impact-of-the-standard-american-diet-in-rats-effects-on-behavior-physiology-and-recovery-from-inflammatory-injury
#5
Stacie K Totsch, Tammie L Quinn, Larissa J Strath, Laura J McMeekin, Rita M Cowell, Barbara A Gower, Robert E Sorge
BACKGROUND AND AIMS: Obesity is a significant health concern in the Western world and the presence of comorbid conditions suggests an interaction. The overlapping distributions of chronic pain populations and obesity suggests that an interaction may exist. Poor quality diet (high carbohydrates, saturated fats, omega-6 polyunsaturated fatty acids) can lead to increased adiposity which can activate immune cells independent of the activating effect of the diet components themselves. This dual action can contribute to chronic inflammation that may alter susceptibility to chronic pain and prolong recovery from injury...
September 16, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28927648/hyperbaric-oxygenation-alleviates-chronic-constriction-injury-cci-induced-neuropathic-pain-and-inhibits-gabaergic-neuron-apoptosis-in-the-spinal-cord
#6
Huiqun Fu, Fenghua Li, Sebastian Thomas, Zhongjin Yang
BACKGROUND AND AIMS: Dysfunction of GABAergic inhibitory controls contributes to the development of neuropathic pain. We examined our hypotheses that (1) chronic constriction injury (CCI)-induced neuropathic pain is associated with increased spinal GABAergic neuron apoptosis, and (2) hyperbaric oxygen therapy (HBO) alleviates CCI-induced neuropathic pain by inhibiting GABAergic neuron apoptosis. METHODS: Male rats were randomized into 3 groups: CCI, CCI+HBO and the control group (SHAM)...
September 15, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28922314/temporal-indices-of-ankle-clonus-and-relationship-to-electrophysiologic-and-clinical-measures-in-persons-with-spinal-cord-injury
#7
Kathleen J Manella, Kathryn E Roach, Edelle C Field-Fote
BACKGROUND AND PURPOSE: Clonus arising from plantar flexor hyperreflexia is a phenomenon that is commonly observed in persons with spastic hypertonia. We assessed the temporal components of a biomechanical measure to quantify ankle clonus, and validated these in persons with spasticity due to spinal cord injury. METHODS: In 40 individuals with chronic (>1 year) spinal cord injury, we elicited ankle clonus using a standardized mechanical perturbation (drop test)...
October 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28905348/-a-rare-complication-of-transrectal-electrostimulation-for-sperm-retrieval
#8
Jürgen Pannek, Dirk Leuth, Jens Wöllner
In men who wish to have children after a spinal cord injury, assisted ejaculation is frequently needed for sperm retrieval. Transrectal electrostimulation (TES) is often used for this purpose. Typical side effects of TES are autonomic dysreflexia or pain. In a 33-year old man with complete tetraplegia below C6 since 2004, TES caused massive leg spasticity, leading to transcervical fracture of the femoral neck. This previously unreported complication of TES demonstrates that, in men with long-term chronic tetraplegia, spasticity and osteoporosis, TES in anesthesia should be taken into consideration...
September 13, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28903493/editor-s-highlight-formulation-and-toxicology-evaluation-of-the-intrathecal-ayx1-dna-decoy-in-sprague-dawley-rats
#9
Julien Mamet, David C Yeomans, Tony L Yaksh, Donald C Manning, Scott Harris
The longevity of pain after surgery is debilitating and limits the recovery of patients. AYX1 is a double-stranded, unprotected, 23 base-pair oligonucleotide designed to reduce acute post-surgical pain and prevent its chronification with a single intrathecal perioperative dose. AYX1 mimics the DNA sequence normally bound by EGR1 on chromosomes, a transcription factor transiently induced in the dorsal root ganglia-spinal cord network following a noxious input. AYX1 binds to EGR1 and prevents it from launching waves of gene regulation that are necessary to maintain pain over time...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28899825/long-term-performance-and-user-satisfaction-with-implanted-neuroprostheses-for-upright-mobility-after-paraplegia-two-to-14-year-follow-up
#10
Ronald J Triolo, Stephanie Nogan Bailey, Kevin M Foglyano, Rudi Kobetic, Lisa M Lombardo, Michael E Miller, Gilles Pinault
OBJECTIVE: To quantify the long-term (LT) (>2 years) effects of lower extremity (LE) neuroprostheses (NPs) for standing, transfers, stepping and seated stability after spinal cord injury. DESIGN: Single-subject design case series with participants acting as their own concurrent controls, including retrospective data review. SETTING: Hospital-based clinical biomechanics laboratory with experienced (>20 years in the field) research biomedical engineers, physical therapist and medical monitoring review...
September 9, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28899427/activation-of-dorsal-horn-cannabinoid-cb2-receptor-suppresses-the-expression-of-p2y12-and-p2y13-receptors-in-neuropathic-pain-rats
#11
Juan Niu, Dujuan Huang, Rui Zhou, MingXia Yue, Tao Xu, Junna Yang, Li He, Hong Tian, XiaoHong Liu, Junwei Zeng
BACKGROUND: More evidence suggests that dorsal spinal cord microglia is an important site contributing to CB2 receptor-mediated analgesia. The upregulation of P2Y12 and P2Y13 purinoceptors in spinal dorsal horn microglia is involved in the development of pain behavior caused by peripheral nerve injury. However, it is not known whether the expression of P2Y12 and P2Y13 receptors at spinal dorsal horn will be influenced after CB2 receptor activation in neuropathic pain rats. METHODS: Chronic constriction injury (CCI) and intrathecal ADPbetaS injection were performed in rats to induce neuropathic pain...
September 12, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28899046/human-neural-stem-cell-transplantation-in-chronic-cervical-spinal-cord-injury-functional-outcomes-at-12-months-in-a-phase-ii-clinical-trial
#12
George M Ghobrial, Kim D Anderson, Marine Dididze, Jasmine Martinez-Barrizonte, Gabriel H Sunn, Katie L Gant, Allan D Levi
No abstract text is available yet for this article.
September 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28895898/reducing-the-shared-burden-of-chronic-conditions-among-persons-aging-with-disability-and-older-adults-in-the-united-states-through-bridging-aging-and-disability
#13
REVIEW
Margaret L Campbell, Michelle Putnam
Persons aging with long-term disabilities such as spinal cord injury or multiple sclerosis and older adults share similar chronic conditions in mid and later life in the United States. The rising general interest and more prevalent federal requirements for use of evidence-based practices (EBP) in health promotion and chronic condition interventions highlight the gap between demand and the availability of EBPs for persons aging with disability in particular. Addressing this gap will require focused efforts that will benefit substantially by bridging the fields of aging and disability/rehabilitation to develop new EBPs, translate existing EBPs across populations, and borrow best practices across fields where there are few current EBPs...
September 12, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28895456/spatial-and-cellular-expression-patterns-of-erythropoietin-receptor-and-erythropoietin-during-a-42-day-post-lesional-time-course-after-graded-thoracic-spinal-cord-impact-lesions-in-the-rat
#14
Gesa Cohrs, Stephan Goerden, Ralf Lucius, Michael Synowitz, Maximilian Hubertus Mehdorn, Janka Held-Feindt, Friederike Knerlich-Lukoschus
Erythropoietin (Epo) exhibits promising neuroregenerative potential for spinal cord injury (SCI) and might be involved in other long-term sequelae, such as neuropathic pain development. The current studies investigated the time courses and spatial and cellular patterns of Epo and EpoR expression along the spinal axis after graded SCI. Male Long Evans rats received 100-kdyn, 150-kdyn, and 200-kdyn thoracic (T9) contusions from an Infinite Horizon Impactor. Sham controls received laminectomies. Anatomical and quantitative immunohistochemical analyses of the EpoR/Epo expression along the whole spinal axis were performed 7, 15, and 42 DPO after the lesioning...
September 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28893707/endovascular-aorto-iliac-revascularization-in-a-patient-with-spinal-cord-injury-and-hip-contracture
#15
Naixin Kang, Stefan Kenel-Pierre, Hilene DeAmorim, John Karwowski, Arash Bornak
Treatment of chronic peripheral ischemic wounds in patients with spinal cord injury (SCI) can be technically challenging, especially if they have significant hip contracture. This paper describes the endovascular aorto-iliac revascularization of a paraplegic patient with hip contracture and a hostile abdomen. It also reviews the particularity of the peripheral arterial system in SCI patients.
September 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28891868/a-bivalent-ligand-that-activates-mu-opioid-receptor-and-antagonizes-mglur5-receptor-reduces-neuropathic-pain-in-mice
#16
Cristina D Peterson, Kelley F Kitto, Eyup Akgün, Mary M Lunzer, Maureen S Riedl, Lucy Vulchanova, George L Wilcox, Philip S Portoghese, Carolyn A Fairbanks
The mu opioid receptor (MOR) and metabotropic glutamate receptor 5 (mGluR5) are well-established pharmacological targets in the management of chronic pain. Both receptors are expressed in spinal cord. MMG22, a bivalent ligand containing two pharmacophores separated by 22 atoms that simultaneously activates MOR and antagonizes mGluR5 has been shown to produce potent reversal of tactile hypersensitivity in rodent models of LPS- and bone-cancer-induced chronic pain. The present study assessed whether intrathecal MMG22 also is effective in reducing pain of neuropathic origin...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28880130/the-effects-of-semi-immersive-virtual-reality-therapy-on-standing-balance-and-upright-mobility-function-in-individuals-with-chronic-incomplete-spinal-cord-injury-a-preliminary-study
#17
Chang-Man An, Young-Hyun Park
Background Individuals with chronic incomplete spinal cord injury (iSCI) commonly face persistent balance or mobility impairments. Virtual reality (VR) therapy is a useful rehabilitation approach; however, little is known about its effects in individuals with chronic iSCI. Objective To investigate the effects of semi-immersive VR therapy on standing balance and upright mobility function in individuals with chronic iSCI. Methods Ten subjects with chronic iSCI underwent VR therapy 30 minutes a day, 3 days a week, for 6 weeks...
September 7, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28877966/t-cell-mediation-of-pregnancy-analgesia-affecting-chronic-pain-in-mice
#18
Sarah F Rosen, Boram Ham, Shannon Drouin, Nadia Boachie, Anne-Julie Chabot-Dore, Jean-Sebastien Austin, Luda Diatchenko, Jeffrey S Mogil
It has been consistently reported that many female chronic pain sufferers have an attenuation of symptoms during pregnancy. Rats display increased pain tolerance during pregnancy, due to an increase in opioid receptors in the spinal cord. These past studies did not consider the role of non-neuronal cells, now appreciated to play an important role in chronic pain processing. Using an inflammatory (complete Freund's adjuvant) or neuropathic (spared nerve injury) model of persistent pain, we observe that young adult female mice in early pregnancy switch from a micgrolia-independent to a microglia-dependent pain hypersensitivity mechanism...
September 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28877964/constitutive-activity-of-5-ht2c-receptors-is-present-following-incomplete-spinal-cord-injury-but-is-not-modified-after-chronic-ssri-or-baclofen-treatment
#19
Vicki Maria Tysseling, David A Klein, Rebecca Imhoff-Manuel, Marin Manuel, Charles J Heckman, Matthew C Tresch
Following spinal cord injury (SCI), reflexes become hyperexcitable, leading to debilitating muscle spasms and compromised motor function. Previous work has described adaptations in spinal systems that might underlie this hyperexcitability, including an increase in constitutively active 5-HT2C receptors in spinal motoneurons. That work, however, examined adaptations following complete transection SCI, whereas SCI in humans is usually anatomically and functionally incomplete. We therefore evaluated whether constitutive activity of 5-HT2C receptors contributes to reflex hyperexcitability in an incomplete compression model of SCI and to spasms in vitro and in vivo...
September 6, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28877136/medicate-or-meditate-greater-pain-acceptance-is-related-to-lower-pain-medication-use-in-persons-with-chronic-pain-and-spinal-cord-injury
#20
Anna L Kratz, John Murphy, Claire Z Kalpakjian, Philip Chen
OBJECTIVES: There is little information about whether use of pain self-management skills that are common targets of psychosocial interventions for pain are associated with reduced reliance on pain medications. The aim of this study was to test whether higher chronic pain acceptance, which is a readily-modified pain self-management approach, is related to lower use of pain medications (all types), opioid medications, and gabapentinoids in a sample with chronic pain and spinal cord injury (SCI)...
September 4, 2017: Clinical Journal of Pain
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