Dan Wu, Jin Su, Ping Wang, Baorong Zhai, Chunhui Zhao, Weijie Li, Chengyu Chen, Jianli Guan, Zhiming Cao, Naining Song, Hongjun Yang, Yanqiong Zhang, Haiyu Xu
ETHNOPHARMACOLOGICAL RELEVANCE: Yuanhu Zhitong Prescription (YZP) is a well-known traditional Chinese medicine (TCM) formula for neuropathic pain (NP) therapy with a satisfying clinical efficacy. However, the underlying pharmacological mechanism and its compatibility principle remain unclear. AIM OF THE STUDY: This study aims to investigate the analgesic and compatibility mechanisms of YZP on neuropathic pain (NP) at the gene and biological process levels. MATERIALS AND METHODS: The chronic constriction injury (CCI) rats were intragastrically administrated with extracts of YZP, YH and BZ separately, and then mechanical hypersensitivity were measured to evaluate the analgesic effects between YH and BZ before and after compatibility...
May 8, 2024: Journal of Ethnopharmacology