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E V Kulakovskaya, M Yu Zemskova, T V Kulakovskaya
This review presents data on the relationship between inorganic polyphosphate metabolism and carcinogenesis including participation of polyphosphates in the regulation of activity of mTOR and other proteins involved in carcinogenesis, the role of h-prune protein (human polyphosphatase) in cell migration and metastasis formation, the prospects for using polyphosphates and inhibitors of polyphosphate metabolism enzymes as agents for controlling cell proliferation and migration.
August 2018: Biochemistry. Biokhimii︠a︡
Doan-Trang Hoang, Diane Schorr, Véronic Landry, Pierre Blanchet, Stéphanie Vanslambrouck, Christian Dagenais
Intumescent fire retardant (IFR) coatings are nowadays considered as the most effective flame retardant (FR) treatment. Nevertheless, the principal compound in an IFR system, ammonium polyphosphate (APP), is highly sensitive to moisture and IFR coating effectiveness decreases quickly. The main objective of this study is to encapsulate APP in a hybrid silica-based membrane by sol-gel process using alkoxysilane tetraethoxysilane (TEOS) and methyltriethoxysilane (MTES) precursor. The morphology and structure of APP and microencapsulated ammonium polyphosphate (MAPP) were assessed by scanning electron miscroscopy and Fourier transform infrared spectroscopy (FTIR)...
September 7, 2018: Journal of Microencapsulation
Valerie F Curtis, Ian M Cartwright, J Scott Lee, Ruth X Wang, Daniel J Kao, Jordi M Lanis, Krista M Burney, Nichole Welch, Caroline H T Hall, Matthew S Goldberg, Eric L Campbell, Sean P Colgan
Extracellular adenosine signaling is established as a protective component in mucosal inflammatory responses. The sources of extracellular adenosine include enzymatic processing from nucleotides, such as ATP and AMP that can be liberated from a variety of cell types, including infiltrating leukocytes. Here, we demonstrate that activated human neutrophils are a source of diadenosine triphosphate (Ap3A), providing an additional source of nucleotides during inflammation. Profiling murine enteroids and intestinal epithelial cell (IEC) lines revealed that intestinal epithelia prominently express apical and lateral ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1), a member of the ENPP family of enzymes that metabolize diadenosine phosphates, especially Ap3A...
September 6, 2018: Molecular Biology of the Cell
Zi Han Qiao, Ran Qi, Zhen Wang, Ya Nan Ding, Jie Yao, Yun Zhang
We explored the effects of carbon supplementary modes on operational performance in a tidal flow constructed wetland (TFCW) utilizing phosphorus bioaccumulation/phosphorus harvesting (PB-PH) process. Three different carbon supplementary modes were adopted during the periodical phosphorus harvesting process. The results showed that the carbon supplementary mode significantly affected the performances of phosphorus bioaccumulation and phosphorus harvesting throughout the experiment. The optimization of carbon supplementary mode would facilitate the maintenance of abundance and activities of polyphosphate-accumulating organisms (PAOs)...
August 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Kid Kohl, Haroun Zangger, Matteo Rossi, Nathalie Isorce, Lon-Fye Lye, Katherine L Owens, Stephen M Beverley, Andreas Mayer, Nicolas Fasel
Protozoan parasites contain negatively charged polymers of a few up to several hundreds of phosphate residues. In other organisms, these poly-phosphate (polyP) chains serve as an energy source and phosphate reservoir, and have been implicated in adaptation to stress and virulence of pathogenic organisms. In this study, we confirmed first that the polyP polymerase vacuolar transporter chaperone 4 ( VTC4 ) is responsible for polyP synthesis in Leishmania parasites. During Leishmania in vitro culture, polyP is accumulated in logarithmic growth phase and subsequently consumed once stationary phase is reached...
June 22, 2018: Microbial Cell
Zhengyu Zhu, Wenling Chen, Tao Tao, Yongmei Li
A novel AAO-SBSPR (Anaerobic-Anoxic-Oxic/Sequencing Batch Sidestream Phosphorus Recovery) process was developed for phosphorus (P) recovery and nutrient removal from municipal wastewater. Meanwhile, an operational strategy based on the P mass balance for the process was proposed, where P recovery rate was coupled with sludge retention time (SRT) so as to reduce the impact of P recovery on P content in activated sludge and maintain a stable operation of the process. The results show that the proposed operational strategy is helpful for the stable operation of the AAO-SBSPR process and up to 65% of the influent P was recovered with the phosphate removal efficiency of 99...
August 27, 2018: Water Research
Euzébio Skovroinski, Rodrigo J de Oliveira, André Galembeck
The development of self-healing materials opens perspectives to fabricate devices with unprecedented lifetimes and recyclability that can be integrated with flexible electronics. However, the timescale at which these materials operate remains an important challenge to overcome. This article describes the fast self-healing behavior of aluminum/iron polyphosphate metallo-gels and their hybrids with polyaniline and gives a detailed investigation of their electrical behaviors. The samples can be cut, molded and healed by manual handling...
August 17, 2018: Journal of Colloid and Interface Science
Dongmei Lin, Xingrong Zeng, Hongqiang Li, Xuejun Lai, Tongyi Wu
Waterproof and flame-retardant fabrics are widely utilized in many fields, such as automotive interiors, indoor decorations, outdoor clothing and tents. Herein, a facile one-pot sol-gel approach was developed to construct superhydrophobic and flame-retardant (SFR) coatings on cotton fabrics. The cotton fabric was activated by O2 plasma and then immersed into the ethanol suspension containing tetraethoxysilane (TEOS), hydroxyl-terminated polydimethylsiloxane (HPDMS) and ammonium polyphosphate (APP). The hydrogen bonding interaction between APP and cellulose motivated the APP to attach to the cotton fibers during the initial stirring process...
August 22, 2018: Journal of Colloid and Interface Science
Tatiana Kulakovskaya
The mechanisms of heavy metal resistance in microbial cells involve multiple pathways. They include the formation of complexes with specific proteins and other compounds, the excretion from the cells via plasma membrane transporters in case of procaryotes, and the compartmentalization of toxic ions in vacuoles, cell wall and other organelles in case of eukaryotes. The relationship between heavy metal tolerance and inorganic polyphosphate metabolism was demonstrated both in prokaryotic and eukaryotic microorganisms...
August 27, 2018: World Journal of Microbiology & Biotechnology
Jesse Barnes, Franklin Salas, Ryan Mokhtari, Hedwig Dolstra, Erika Pedrosa, Herbert M Lachman
Background: Lowe syndrome (LS) is a rare genetic disorder caused by loss of function mutations in the X-linked gene, OCRL , which codes for inositol polyphosphate 5-phosphatase. LS is characterized by the triad of congenital cataracts, neurodevelopmental impairment (primarily intellectual and developmental disabilities [IDD]), and renal proximal tubular dysfunction. Studies carried out over the years have shown that hypomorphic mutations in OCRL adversely affect endosome recycling and actin polymerization in kidney cells and patient-derived fibroblasts...
2018: Molecular Autism
Akihiro Nakamura, Natsuko Kawano, Kei Motomura, Akio Kuroda, Kiyoshi Sekiguchi, Mami Miyado, Kang Woojin, Yoshitaka Miyamoto, Maito Hanai, Maki Iwai, Mitsutoshi Yamada, Toshio Hamatani, Takakazu Saito, Hidekazu Saito, Mamoru Tanaka, Akihiro Umezawa, Kenji Miyado
In bacteria, a polymer of inorganic phosphate (Pi) (inorganic polyphosphate; polyP) is enzymatically produced and consumed as an alternative phosphate donor for adenosine triphosphate (ATP) production to protect against nutrient starvation. In vertebrates, polyP has been dismissed as a "molecular fossil" due to the lack of any known physiological function. Here, we have explored its possible role by producing transgenic mice (TG) widely expressing Saccharomyces cerevisiae exoplyphosphatase 1 (ScPPX1), which catalyzes hydrolytic polyP degradation...
August 24, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
Shanhong Wan, A Kiet Tieu, Qiang Zhu, Hongtao Zhu, Shaogang Cui, David R G Mitchell, Charlie Kong, Bruce Cowie, John A Denman, Rong Liu
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
August 24, 2018: Scientific Reports
Yan Song, Xu Zong, Nan Wang, Ning Yan, Xueying Shan, Jinchun Li
Lignin can be a candidate as a charring agent applied in halogen-free flame retardant polymers, and incorporation of silicon and nitrogen elements in lignin can benefit to enhancing its thermal stability and charring ability. In the present work, wheat straw alkali lignin (Lig) was modified to incorporate silicon and nitrogen elements by γ-divinyl-3-aminopropyltriethoxysilane, and the modified lignin (CLig) was combined with ammonium polyphosphate (APP) as intumescent flame retardant to be applied in poly(Lactic acid) (PLA)...
August 22, 2018: Materials
Dong Li, Jingyan Yang, Huanzhi Ma, Chengliang Sun, Rongjie Feng
Osteosarcoma (OS) is an aggressive malignant tumor of bone, which often occurs in children and adolescents. Currently, the effective method for the treatment of OS is still limited. The study aimed to investigate the synergistic antitumor effect of inositol polyphosphate-4-phosphatase, type-II (INPP4B) and rucaparib on OS cells. The expression levels of INPP4B in OS tissues and OS cell lines were examined by quantitative real-time polymerase chain reaction and Western blot analysis. SaOS2 and U2OS cells were then transfected with overexpression vector of INPP4B or were treated with different concentrations of rucaparib, and cell viability, cell cycle, and apoptosis were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and flow cytometry...
August 21, 2018: Journal of Cellular Biochemistry
Nicholas G Yoo, Siddhant Dogra, Ben A Meinen, Eric Tse, Janine Haefliger, Daniel R Southworth, Michael J Gray, Jan-Ulrik Dahl, Ursula Jakob
Inorganic polyphosphate (polyP) constitutes one of the most conserved and ubiquitous molecules in biology. Recent work in bacteria demonstrated that polyP increases oxidative stress resistance by preventing stress-induced protein aggregation and promotes biofilm formation by stimulating functional amyloid formation. To gain insights into these two seemingly contradictory functions of polyP, we investigated the effects of polyP on the folding model lactate dehydrogenase. We discovered that the presence of polyP during the thermal unfolding process stabilizes folding intermediates of lactate dehydrogenase as soluble micro-β-aggregates with amyloid-like properties...
August 18, 2018: Journal of Molecular Biology
Yuanying Chen, Yefeng Yuan, Wei Li
Platelets respond to vascular injury via surface receptor stimulation and signaling events to trigger aggregation, procoagulant activation, and granule secretion during hemostasis, thrombosis, and vascular remodeling. Platelets contain three major types of secretory granules including dense granules (or δ-granules, DGs), α-granules (AGs), and lysosomes. The contents of platelet granules are specific. Platelet DGs store polyphosphate and small molecules such as ADP, ATP, Ca2+ , and serotonin, while AGs package most of the proteins that platelets release...
October 31, 2018: Bioscience Reports
Nebibe Mutlu, Anuj Kumar
In response to various environmental stimuli and stressors, the budding yeast Saccharomyces cerevisiae can initiate a striking morphological transition from its classic growth mode as isolated single cells to a filamentous form in which elongated cells remain connected post-cytokinesis in multi-cellular pseudohyphae. The formation of pseudohyphal filaments is regulated through an expansive signaling network, encompassing well studied and highly conserved pathways enabling changes in cell polarity, budding, cytoskeletal organization, and cell adhesion; however, changes in metabolite levels underlying the pseudohyphal growth transition are less well understood...
August 12, 2018: Current Genetics
Ashima Bhaskar, Cyntia De Piano, Ekaterina Gelman, John D McKinney, Neeraj Dhar
Bacterial persistence, the ability of bacteria to survive high concentrations of antibiotics for extended periods of time, is an important contributing factor to therapy failure and development of chronic and recurrent infections. Several recent studies have suggested that this persistence is mediated primarily by (p)ppGpp, through its interactions with toxin-antitoxin modules and polyphosphates. In this study, we address whether these key players play a role in mycobacterial persistence against antibiotics...
September 2018: IUBMB Life
Shu Zhu, Bradley A Herbig, Xinren Yu, Jason Chen, Scott L Diamond
Microfluidic thrombosis assays allow the control of anticoagulation, hemodynamics, pharmacology, and procoagulant surfaces containing collagen ± tissue factor (TF). With corn trypsin inhibitor (CTI) ranging from low (1-4 μg/mL) to high levels (40-60 μg/mL), the function of Factor XIIa (FXIIa) can be modulated in the presence of low or high surface TF. With high CTI and no collagen/TF in the assay, no thrombin is generated during 15-min microfluidic perfusion. At low CTI (no TF), the generation of FXIa leads to fibrin polymerization at ~300 s after the initiation of flow over collagen, an onset time shortened at zero CTI and prolonged at high CTI...
2018: Frontiers in Medicine
Qingcheng Li, Liang Fu, Yue Wang, Dandan Zhou, Bruce E Rittmann
A high phosphorus concentration is widely accepted as favorable for enhancing both microalgae growth and lipid accumulation; however, excessively high P could be counter-productive. In this study, we investigated the effects of increasing P levels (5.4, 25, 45, 150, and 250 mg-P L-1 ) on the heterotrophic cultivation of Chlorella regularis. Microalgae growth was inhibited and cells were severely damaged in response to highly excessive P levels (≥150 mg-P L-1 ). In particular, 250 mg-P L-1 resulted in a ∼40% decrease in cell density and a ∼70% loss of cell viability...
August 1, 2018: Bioresource Technology
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