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https://www.readbyqxmd.com/read/28314208/long-term-effects-of-sulphide-on-the-enhanced-biological-removal-of-phosphorus-the-symbiotic-role-of-thiothrix-caldifontis
#1
F J Rubio-Rincón, L Welles, C M Lopez-Vazquez, M Nierychlo, B Abbas, M Geleijnse, P H Nielsen, M C M van Loosdrecht, D Brdjanovic
Thiothrix caldifontis was the dominant microorganism (with an estimated bio-volume of 65 ± 3%) in a lab-scale enhanced biological phosphorus removal (EBPR) system containing 100 mg of sulphide per litre in the influent. After a gradual exposure to the presence of sulphide, the EBPR system initially dominated by Candidatus Accumulibacter phosphatis Clade I (98 ± 3% bio-volume) (a known polyphosphate accumulating organism, PAO) became enriched with T. caldifontis. Throughout the different operating conditions studied, practically 100% phosphate removal was always achieved...
March 7, 2017: Water Research
https://www.readbyqxmd.com/read/28302909/ppn2-a-novel-zn-2-dependent-polyphosphatase-in-the-acidocalcisome-like-yeast-vacuole
#2
Rūta Gerasimaitė, Andreas Mayer
Acidocalcisome-like organelles are found in all kingdoms of life. Many of their functions, such as the accumulation and storage of metal ions, nitrogen and phosphate, the activation of blood clotting and inflammation, depend on the controlled synthesis and turnover of polyphosphate (polyP), a polymer of inorganic phosphate linked by phosphoric anhydride bonds. The exploration of the role of acidocalcisomes in metabolism and physiology requires manipulation of polyP turnover, yet the complete set of proteins responsible for this turnover is unknown...
March 16, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28299750/impacts-of-cerium-oxide-nanoparticles-on-bacterial-community-in-activated-sludge
#3
I Kamika, M Tekere
Rapidly developing industry raises concerns about the environmental impacts of nanoparticles, but the effects of inorganic nanoparticles on bacterial community in wastewater treatment remain unclear. The present research assessed the impact of cerium oxide nanoparticles (nCeO) on the microbiome of activated sludge system. The results showed that 18,330 over 28,201 reads generated from control samples were assigned to Proteobacteria while 5527 reads (19.6%), 3260 reads (11.567%), and 719 reads (2.55%) were assigned to unclassified_Bacteria, Firmicutes and Actinobacteria, respectively...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28298624/strong-antibiotic-production-is-correlated-with-highly-active-oxidative-metabolism-in-streptomyces-coelicolor-m145
#4
Catherine Esnault, Thierry Dulermo, Aleksey Smirnov, Ahmed Askora, Michelle David, Ariane Deniset-Besseau, Ian-Barry Holland, Marie-Joelle Virolle
The Streptomyces genus is well known for its ability to produce bio-active secondary metabolites of great medical interest. However, the metabolic features accompanying these bio-productions remain to be defined. In this study, the comparison of related model strains producing differing levels of actinorhoddin (ACT), showed that S. lividans, a weak producer, had high TriAcylGlycerol (TAG) content indicative of a glycolytic metabolism. In contrast, the strong producer, S. coelicolor, was characterized by low TAG content, active consumption of its polyphosphate (PolyP) stores and extremely high ATP/ADP ratios...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28294611/a3sr2p7o21-a-rb-cs-two-polyphosphates-based-on-different-types-of-p-o-chains-and-ring-structures
#5
Maierhaba Abudoureheman, Shujuan Han, Ying Wang, Bing-Hua Lei, Zhihua Yang, Shilie Pan
Two polyphosphates containing two types of polymerization of the [PO4] groups, Rb3Sr2P7O21 and Cs3Sr2P7O21, were grown through a spontaneous nucleation method. Single-crystal X-ray diffraction data were collected in order to determine their structures. Interestingly, Rb3Sr2P7O21 is the first example of two kinds of [PO3]∞ linear chains coexisting in one phosphate structure. However, in the structure of Cs3Sr2P7O21, the isolated [P4O12] ring and the 1D [PO3]∞ chain can be observed, which is also rare in phosphates...
March 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28291662/polyphosphate-metabolism-by-purple-non-sulfur-bacteria-and-its-possible-application-on-photo-microbial-fuel-cell
#6
Yen-Chun Lai, Chih-Ming Liang, Shu-Chuan Hsu, Ping-Heng Hsieh, Chun-Hsiung Hung
A purple non-sulfur bacterium, Rhodopseudomonas palustris G11, was isolated from an activated sludge plant that treats domestic wastewater. This isolation resulted in the effective accumulation of polyphosphate in cells upon reaching the stationary growth phase. However, when the carbon and/or energy source were/was removed, this bacterium released intracellular polyphosphate or poly-β-hydroxybutyrate to obtain energy to grow or maintain its growth. Furthermore, a novel photo-microbial fuel cell (PMFC) design was proposed...
March 11, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28279597/inferior-vena-cava-filters-in-pulmonary-embolism-a-historic-controversy
#7
Carlos Jerjes-Sanchez, David Rodriguez, Aline Navarrete, Carolina Parra-Cantu, Jorge Joya-Harrison, Eduardo Vazquez, Alicia Ramirez-Rivera
OBJECTIVE: Rationale for non-routine use of inferior venous cava filters (IVCF) in pulmonary embolism (PE) patients. METHODS: Thrombosis mechanisms involved with IVCF placement and removal, the blood-contacting medical device inducing clotting, and the inorganic polyphosphate in the contact activation pathway were analyzed. In addition, we analyzed clinical evidence from randomized trials, including patients with and without cancer. Furthermore, we estimated the absolute risk reduction (ARR), the relative risk reduction (RRR), and the number needed to treat (NNT) based on the results of each study using a frequency table...
March 6, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28277783/origin-of-life-and-the-phosphate-transfer-catalyst
#8
Radosław W Piast, Rafał M Wieczorek
In this paper, we revisit several issues relevant to origin-of-life research and propose a Phosphate Transfer Catalyst hypothesis that furthers our understanding of some of the key events in prebiotic chemical evolution. In the Phosphate Transfer Catalyst hypothesis, we assume the existence of hypothetical metallopeptides with phosphate transfer activity that use abundant polyphosphates as both substrates and energy sources. Nonspecific catalysis by this phosphate transfer catalyst would provide a variety of different products such as phosphoryl amino acids, nucleosides, polyphosphate nucleotides, nucleic acids, and aminoacylated nucleic acids...
March 2017: Astrobiology
https://www.readbyqxmd.com/read/28273533/effects-of-polyphosphates-and-orthophosphate-on-the-dissolution-and-transformation-of-zno-nanoparticles
#9
Biao Wan, Yupeng Yan, Yuanzhi Tang, Yuge Bai, Fan Liu, Wenfeng Tan, Qiaoyun Huang, Xionghan Feng
The fate and toxicity of zinc oxide nanoparticles (ZnO NPs) in nature are affected by solution chemistry such as pH, anions, and natural organic matter (NOM). Inorganic polyphosphates are environmentally ubiquitous phosphorus (P) species that may change the speciation and environmental fate of ZnO NPs. In this study, the interactions of polyphosphates with ZnO NPs and the impacts on ZnO NP dissolution and transformation were investigated and compared with orthophosphate (P1). The results revealed that pyrophosphate (P2), tripolyphosphate (P3), and hexametaphosphate (P6) enhanced whereas P1 inhibited the dissolution of ZnO NPs...
February 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/28266012/factors-influencing-gelation-properties-of-corn-germ-proteins
#10
Xiang Dong Sun, Dan Shi, Yu Lan, Xin Miao Yao, Rui Ying Zhang, Ying Lei Zhang, Ping Su, Hong Shan
BACKGROUND: As a by-product of oil industry, corn germ meal is mainly applied as a high-protein ingredient in animal feeds without any application of the specific functional properties of corn germ protein (CGP). Factors influencing gelation properties of CGP in relation to its dynamic rheology are still unclear due to limited information. RESULTS: CGP concentrate was recovered by the isoelectric precipitation method and factors affecting its gelation properties were investigated using a rheometer...
March 7, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28265086/polyphosphate-granule-biogenesis-is-temporally-and-functionally-tied-to-cell-cycle-exit-during-starvation-in-pseudomonas-aeruginosa
#11
Lisa R Racki, Elitza I Tocheva, Michael G Dieterle, Meaghan C Sullivan, Grant J Jensen, Dianne K Newman
Polyphosphate (polyP) granule biogenesis is an ancient and ubiquitous starvation response in bacteria. Although the ability to make polyP is important for survival during quiescence and resistance to diverse environmental stresses, granule genesis is poorly understood. Using quantitative microscopy at high spatial and temporal resolution, we show that granule genesis in Pseudomonas aeruginosa is tightly organized under nitrogen starvation. Following nucleation as many microgranules throughout the nucleoid, polyP granules consolidate and become transiently spatially organized during cell cycle exit...
March 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28262043/phosphorus-rich-structures-and-capsular-architecture-in-cryptococcus-neoformans
#12
Caroline L Ramos, Fabio M Gomes, Wendell Girard-Dias, Fernando P Almeida, Priscila C Albuquerque, Matthias Kretschmer, James W Kronstad, Susana Frases, Wanderley de Souza, Marcio L Rodrigues, Kildare Miranda
AIM: In this study, we aimed to analyze the relationship of phosphorus-rich structures with surface architecture in Cryptococcus neoformans. METHODS: Phosphorus-rich structures in C. neoformans were analyzed by combining fluorescence microscopy, biochemical extraction, scanning electron microscopy, electron probe x-ray microanalysis and 3D reconstruction of high pressure frozen and freeze substituted cells by focused ion beam-scanning electron microscopy (FIB-SEM)...
March 2017: Future Microbiology
https://www.readbyqxmd.com/read/28261855/inpp4b-overexpression-suppresses-migration-invasion-and-angiogenesis-of-human-prostate-cancer-cells
#13
Haiwen Chen, Hongliang Li, Qi Chen
Inositol polyphosphate 4-phosphatase B (INPP4B) has been identified as a tumor suppressor in different human cancers. However, the role of INPP4B in the angiogenesis of human prostate cancer cells remains unclear. In this study, we first compared the expression of INPP4B between prostate cancer tissues and tumor-adjacent normal prostate tissues using immunohistochemistry. Then, we explored the role of INPP4B in prostate cancer progression via transfection of a Flag-INPP4B plasmid into PC3 and DU145 cells in vitro and in vivo...
March 6, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28258135/unusual-versatility-revealed-by-a-filamentous-diazotrophic-cyanobacterium-anabaena-torulosa-for-its-survival-under-prolonged-uranium-exposure
#14
Celin Acharya, Pallavi Chandwadkar, Chandrani Nayak
Reports on cyanobacterial interactions with uranyl carbonate are rare. Here, we present an interesting succession of the metabolic responses employed by a marine, filamentous, diazotrophic cyanobacterium, Anabaena torulosa for its survival following prolonged exposure to uranyl carbonate extending up to 384 h at pH 7.8 under phosphate limited conditions. The cells sequestered uranium (U) in their polyphosphates on initial exposure to 100 μM uranyl carbonate for 24-28 h. Further incubation until 120 h resulted in (a) significant degradation of cellular polyphosphates causing extensive chlorosis and cell lysis, (b) akinete differentiation followed by (c) extracellular uranyl precipitation...
March 3, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28242205/biological-phosphorus-removal-in-an-extended-asm2-model-roles-of-extracellular-polymeric-substances-and-kinetic-modeling
#15
Shan-Shan Yang, Ji-Wei Pang, Wan-Qian Guo, Xiao-Yin Yang, Zhong-Yang Wu, Nan-Qi Ren, Zhi-Qing Zhao
This paper presents the results of an extended ASM2 model for the modeling and calibration of the role of extracellular polymeric substances (EPS) in phosphorus (P) removal in an anaerobic-aerobic process. In this extended ASM2 model, two new components, the bound EPS (XEPS) and the soluble EPS (SEPS), are introduced. Compared with the ASM2, 7.71, 8.53, and 9.28% decreases in polyphosphate (polyP) were observed in the extended ASM2 in three sequencing batch reactors feeding with different COD/P ratios, indicating that 7...
January 27, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28240542/community-assembly-and-ecology-of-activated-sludge-under-photosynthetic-feast-famine-conditions
#16
Ben O Oyserman, Joseph M Martirano, Spenser Wipperfurth, Brian R Owen, Daniel R Noguera, Katherine D McMahon
Here, we demonstrate that photosynthetic oxygen production under light-dark and feast-famine cycles with no mechanical aeration and negligible oxygen diffusion is able to maintain phosphorus cycling activity associated with the enrichment of polyphosphate accumulating organisms (PAOs). We investigate the ecology of this novel system by conducting a time series analysis of prokaryotic and eukaryotic biodiversity using the V3-V4 and V4 regions of the 16S and 18S rRNA gene sequences, respectively. In the Eukaryotic community, the initial dominant alga observed was Desmodesmus...
March 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28238041/electrospinning-of-bioactive-wound-healing-nets
#17
Heinz C Schröder, Emad Tolba, Bärbel Diehl-Seifert, Xiaohong Wang, Werner E G Müller
The availability of appropriate dressings for treatment of wounds, in particular chronic wounds, is a task that still awaits better solutions than provided by currently applied materials. The method of electrospinning enables the fabrication of novel materials for wound dressings due to the high surface area and porosity of the electrospun meshes and the possibility to include bioactive ingredients. Recent results show that the incorporation of biologically active inorganic polyphosphate microparticles and microspheres and synergistically acting retinoids into electrospun polymer fibers yields biocompatible and antibacterial mats for potential dressings with improved wound-healing properties...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28238040/biocalcite-and-carbonic-acid-activators
#18
Xiaohong Wang, Meik Neufurth, Emad Tolba, Shunfeng Wang, Heinz C Schröder, Werner E G Müller
Based on evolution of biomineralizing systems and energetic considerations, there is now compelling evidence that enzymes play a driving role in the formation of the inorganic skeletons from the simplest animals, the sponges, up to humans. Focusing on skeletons based on calcium minerals, the principle enzymes involved are the carbonic anhydrase (formation of the calcium carbonate-based skeletons of many invertebrates like the calcareous sponges, as well as deposition of the calcium carbonate bioseeds during human bone formation) and the alkaline phosphatase (providing the phosphate for bone calcium phosphate-hydroxyapatite formation)...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28238039/new-target-sites-for-treatment-of-osteoporosis
#19
Werner E G Müller, Xiaohong Wang, Heinz C Schröder
In the last few years, much progress has been achieved in the discovery of new drug target sites for treatment of osteoporotic disorders, one of the main challenging diseases with a large burden for the public health systems. Among these new agents promoting bone formation, shifting the impaired equilibrium between bone anabolism and bone catabolism in the direction of bone synthesis are inorganic polymers, in particular inorganic polyphosphates that show strong stimulatory effects on the expression of bone anabolic marker proteins and hydroxyapatite formation...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28223411/pentraxin-3-is-a-pi3k-signaling-target-that-promotes-stem-cell-like-traits-in-basal-like-breast-cancers
#20
Clémence Thomas, Whitney Henry, Benjamin G Cuiffo, Anthony Y Collmann, Elisabetta Marangoni, Vanessa Benhamo, Manoj K Bhasin, Cheng Fan, Laetitia Fuhrmann, Albert S Baldwin, Charles Perou, Anne Vincent-Salomon, Alex Toker, Antoine E Karnoub
Basal-like breast cancers (BLBCs) exhibit hyperactivation of the phosphoinositide 3-kinase (PI3K) signaling pathway because of the frequent mutational activation of the PIK3CA catalytic subunit and the genetic loss of its negative regulators PTEN (phosphatase and tensin homolog) and INPP4B (inositol polyphosphate-4-phosphatase type II). However, PI3K inhibitors have had limited clinical efficacy in BLBC management because of compensatory amplification of PI3K downstream signaling loops. Therefore, identification of critical PI3K mediators is paramount to the development of effective BLBC therapeutics...
February 21, 2017: Science Signaling
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