CARDUUS MARIANUS 

Cadmium is a heavy metal of considerable environmental concern that causes liver damage. This study examined the possible prevention of cadmium toxicity in human HepG2 cells and primary rat hepatocytes by Hepeel(®), a combined preparation of tinctures from seven different plants. Hepeel(®) prevented cadmium chloride (CdCl(2))-induced cell death in both HepG2 cells and hepatocytes, and also reduced the loss of glutathione, lipid peroxidation, nuclear fragmentation, caspase activation and release of mitochondrial cytochrome C...

Hepeel is a homeopathic remedy commonly used to treat primary and secondary functional disorders of the liver. It consists of highly diluted extracts from the following plants: Chelidonium from Chelidonium majus, L., Carduus marianus from Silybum marianum, L., Veratrum from Veratrum album L., Colocynthis from Citrullus colocynthis L., Lycopodium from Lycopodium clavatum L., Nux moschata from Myristica fragans, Houtt, and China from Cinchona pubescens, Vahl. The antioxidative, antiproliferative and biochemical effects in HepG2 hepatoblastoma cells of serial dilutions of these plant tinctures were tested, either separately or in various combinations...

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The mixture of flavonoids (silymarin) from Carduus Marianus (0.9 mg.g-1 body weight) and/or ascorbic acid (0.4 mg.g-1 body weight) were administered in the food to 21 day-old (b.w. 35-45 g) rats for one week. Then the animals were exposed, in a hypobaric chamber, to simulated altitude 8,000-12,000 m for one hour. Mean lethal altitude was calculated by the Behrens equation: it was 10,150 m in controls, 10,550 m in ascorbic acid treated, 10,500 m in silymarin and tocopherol treated and 10,450 m in animals, receiving both ascorbic acid and silymarin...

The separation of ten plant extracts using automated multiple development thin-layer chromatography (AMD -TLC) is described. Alcoholic extracts were obtained from Cinchona succirubra, Aesculus hippocastanum, Berberis vulgaris. Artemisia abrotanum, Carduus marianus, Thuja occidentalis, Baptisia tinctoria, Paulinia cupana, Lycopus europaeus and Echinacea angustifolia. The separation was performed on silica plates (Sil G-50 UV 254 (Macherey-Nagel), 10 x 20 cm). AMD was achieved in 25 steps using methanol, ethyl acetate, toluene, 1,2-dichloroethane, 25% ammonia solution and anhydrous formic acid as modifiers...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

No abstract text is available yet for this article.