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Spinal cord implants

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https://www.readbyqxmd.com/read/29454118/the-factors-affecting-the-difficulty-of-percutaneous-cylindrical-electrode-placement-for-spinal-cord-stimulation
#1
Kyohei Kin, Takashi Agari, Takao Yasuhara, Yousuke Tomita, Ken Kuwahara, Ittetsu Kin, Michiari Umakoshi, Jun Morimoto, Mihoko Okazaki, Tatsuya Sasaki, Isao Date
OBJECTIVE: Optimal placement of electrodes is important for spinal cord stimulation. Unfortunately, factors affecting the difficulty of percutaneous electrode placement are not well known. In this study, we retrospectively evaluated the factors affecting the difficulty of percutaneous electrode placement. METHODS: The authors performed a retrospective analysis of 90 consecutive procedures of percutaneous cylindrical electrodes implantation at the first author's institution...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29411711/microstructure-and-in-vivo-characterization-of-multi-channel-nerve-guidance-scaffolds
#2
Kendell Pawelec, Jacob Koffler, Dena Shahriari, Angelica Rose Galvan, Mark Tuszynski, Jeff Sakamoto
In a previous study, we demonstrated a novel manufacturing approach to fabricate multi-channel scaffolds (MCS) for use in spinal cord injuries (SCI). In the present study, we extended similar materials processing technology to fabricate significantly longer (5X) porous poly caprolactone (PCL) MCS and evaluated their efficacy in 1 cm sciatic peripheral nerve injury (PNI) model. Due to the increase in MCS dimensions and the challenges that may arise in a longer nerve gap model, microstructural characterization involved MCS wall permeability to assess nutrient flow, topography to understand cell integration, and microstructural uniformity to evaluate the potential for homogeneous linear axon guidance...
February 7, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29408391/single-injection-ex-ovo-transplantation-method-for-broad-spinal-cord-engraftment-of-human-pluripotent-stem-cell-derived-motor-neurons
#3
Maria C Estevez-Silva, Akshitha Sreeram, Stephanie Cuskey, Nikolai Fedorchak, Nisha Iyer, Randolph S Ashton
BACKGROUND: Transplantation of human pluripotent stem cell (hPSC)-derived neurons into chick embryos is an established preliminary assay to evaluate engraftment potential. Yet, with recent advances in deriving diverse human neuronal subtypes, optimizing and standardizing such transplantation methodology for specific subtypes at their correlated anatomical sites is still required. NEW METHOD: We determined the optimal stage of hPSC-derived motor neuron (hMN) differentiation for ex ovo transplantation, and developed a single injection protocol that implants hMNs throughout the spinal cord enabling broad regional engraftment possibilities...
February 3, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29403246/surgical-management-of-c-type-subaxial-cervical-fractures-using-cervical-traction-followed-by-anterior-cervical-discectomy-and-fusion-within-12-h-after-the-trauma
#4
Pasquale Donnarumma, Vincenzo Bozzini, Gaetano Rizzi, Arturo Berardi, Gaetano Merlicco
Study Design: This was a retrospective cohort study. Objective: To report our 10-year experience of closed reduction using Crutchfield traction followed by anterior cervical discectomy and fusion within 12 h from injury for C-type subaxial cervical fractures (according to the AOSpine classification system). Methods: Clinical records and neuroimaging were retrospectively reviewed. Surgical details were provided. Results: A total of 22 patients were included in the study...
October 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29395078/implantation-of-a-matrigel-loaded-agarose-scaffold-promotes-functional-regeneration-of-axons-after-spinal-cord-injury-in-rat
#5
Sungmin Han, Jee Youn Lee, Eun Young Heo, Il Keun Kwon, Tae Young Yune, Inchan Youn
An agarose scaffold can be useful for supporting and guiding injured axons after spinal cord injury (SCI), but the electrophysiological signal of regenerated axon in scaffolds has not yet been determined. The current study investigated whether a Matrigel-loaded agarose scaffold would enhance the regeneration of axons after SCI. Moreover, the functional connectivity of regenerated axons within the channels of the scaffold was evaluated by directly recording motor evoked potentials. Our data showed that the agarose scaffold containing Matrigel can support and enhance linearly organized axon regeneration after SCI...
January 30, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29394937/side-effects-of-ct-guided-implantation-of-125i-seeds-for-recurrent-malignant-tumors-of-the-head-and-neck-assisted-by-3d-printing-non-co-planar-template
#6
Yuliang Jiang, Zhe Ji, Fuxin Guo, Ran Peng, Haitao Sun, Jinghong Fan, Shuhua Wei, Weiyan Li, Kai Liu, Jinghua Lei, Junjie Wang
BACKGROUND: For the recurrence of head and neck cancer after operation and radiotherapy, the local control of radioactive seed implantation is good, and it has a certain palliative effect. This study aims to investigate the acute and late side effects of a three-dimentional printing non co-planar template (3D-PNCT) for computed tomography (CT)-guided radioactive 125I seed (RIS) implantation in recurrent cancer of the head and neck. METHODS: Between January 2016 and December 2016, forty-two patients with local recurrent malignant tumors of the head and neck received 3D-PNCT-assisted RIS implantation...
February 3, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29377343/spinal-cord-stimulation-improves-the-microvascular-perfusion-insufficiency-caused-by-critical-limb-ischemia
#7
Jung-Tung Liu, Chen-Hsing Su, Se-Yi Chen, Sang-Jek Liew, Cheng-Siu Chang
OBJECTIVE: This retrospective case-controlled study intended to identify the benefits and efficacy of spinal cord stimulation (SCS) as a therapeutic strategy for patients with perfusion problems caused by critical limb ischemia (CLI). The outcomes of patients who received SCS were compared with those of patients who did not receive SCS. METHODS: This study recruited 78 patients who were diagnosed with perfusion problems over the period of 2003-2011. Lower-limb Thallium-201 (201 Tl) scintigraphy revealed that the patients exhibited a perfusion difference of <0...
January 26, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29375941/use-of-spinal-cord-stimulation-in-elderly-patients-with-multi-factorial-chronic-lumbar-and-non-radicular-lower-extremity-pain
#8
Michelle Granville, Aldo F Berti, Robert E Jacobson
Spinal cord stimulation (SCS) is an effective treatment for chronic back and limb pain. The criteria for use of SCS for specific problems such as failed back surgery syndrome (FBSS), peripheral neuropathic pain and residual pain after joint replacement is well established. With an aging population, there are more patients presenting with a combination of various multi-factorial chronic pain problems rather than from a single clear cause. It is not uncommon to see patients with chronic back pain years after spine surgery with new additional pain in the area of joint replacement or due to peripheral neuropathy...
November 17, 2017: Curēus
https://www.readbyqxmd.com/read/29372855/placement-of-baclofen-pump-catheter-through-a-c1-2-puncture-technical-note
#9
Zaid Aljuboori, Jacob Archer, Wei Huff, Amee Moreno, Andrew Jea
Intrathecal baclofen has been suggested as an effective and safe treatment for intractable spasticity and dystonia. Techniques of lumbar and intraventricular catheter placement have been previously described. The purpose of this study was to describe a technique to implant catheters for intrathecal baclofen infusion through C1-2 puncture. Four of 5 consecutively treated patients underwent successful placement of catheters for intrathecal baclofen. There were no instances of infection, CSF leak, or catheter migration seen during a follow-up period of at least 6 months; furthermore, there were no occurrences of vertebral artery or spinal cord injury...
January 26, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29363873/the-long-term-durability-of-multi-lumen-concentric-percutaneous-spinal-cord-stimulator-leads
#10
Thomas Simopoulos, Sanjiv Sharma, Moris Aner, Jatinder S Gill
BACKGROUND: Lead fracture is a well-known complication of cylindrical spinal cord stimulator leads. In order to reduce this complication, anchor design and techniques have been modified, but internal lead design has received little attention. OBJECTIVES: The goal of this study was to study the impact of lead design by a retrospective determination of the fracture rate of multi-lumen concentric (MLC) 8 contact leads. STUDY DESIGN: Retrospective chart review...
January 24, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29360994/the-risk-of-spinal-cord-injury-during-the-frozen-elephant-trunk-procedure-in-acute-aortic-dissection
#11
Boris N Kozlov, Dmitri S Panfilov, Igor V Ponomarenko, Andrey G Miroshnichenko, Aleksandra A Nenakhova, Alexander I Maksimov, Vladimir M Shipulin
OBJECTIVES: The aim of the study was to access the extended occlusion of the intercostal arteries by a stent graft in the development of postoperative spinal cord injury during aortic arch surgery using the frozen elephant trunk technique. METHODS: A total of 37 consecutive patients underwent total aortic arch surgery using the frozen elephant trunk technique between March 2012 and July 2017. The mean age of the patients was 54.7 ± 10.5 years. Type A and Type B aortic dissections were the indications for surgery...
January 17, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29353106/perineurium-like-sheath-derived-from-long-term-surviving-mesenchymal-stem-cells-confers-nerve-protection-to-the-injured-spinal-cord
#12
Yuan-Huan Ma, Xiang Zeng, Xue-Cheng Qiu, Qing-Shuai Wei, Ming-Tian Che, Ying Ding, Zhou Liu, Guo-Hui Wu, Jia-Hui Sun, Mao Pang, Li-Min Rong, Bin Liu, Zaid Aljuboori, Inbo Han, Eng-Ang Ling, Yuan-Shan Zeng
The functional multipotency enables mesenchymal stem cells (MSCs) promising translational potentials in treating spinal cord injury (SCI). Yet the fate of MSCs grafted into the injured spinal cord has not been fully elucidated even in preclinical studies, rendering concerns of their safety and genuine efficacy. Here we used a rat spinal cord transection model to evaluate the cell fate of allograft bone marrow derived MSCs. With the application of immunosuppressant, donor cells, delivered by biocompatible scaffold, survived up to 8 weeks post-grafting...
January 11, 2018: Biomaterials
https://www.readbyqxmd.com/read/29346227/refractory-pain-management-in-amyloid-associated-peripheral-neuropathy
#13
Nafisseh S Warner, James C Watson, Markus A Bendel, Susan M Moeschler
OBJECTIVE: Systemic amyloidosis is a disease that often involves multiple organ systems, including the peripheral nervous system. Patients may present with severe, refractory neuropathic pain; however, the optimal treatment approach for pain for these patients remains unclear. CASE REPORT: A man with severe, refractory neuropathic pain in his bilateral upper and lower extremities and the trunk secondary to amyloid neuropathy is presented. Multiple medication trials, including neuropathic and opioid agents, produced considerable adverse effects and minimal relief...
January 17, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29346102/impedance-measures-during-in-vitro-cochlear-implantation-predict-array-positioning
#14
Christopher Kenneth Giardina, Elliot Samuel Krause, Kanthaiah Koka, Douglas Carl Fitzpatrick
OBJECTIVE: Improper electrode placement during cochlear implant (CI) insertion can adversely affect speech perception outcomes. However, the intraoperative methods to determine positioning are limited. Because measures of electrode impedance can be made quickly, the goal of this study was to assess the relationship between CI impedance and proximity to adjacent structures. METHODS: An Advanced Bionics CI array was inserted into a clear, plastic cochlea one electrode contact at a time in a saline bath (nine trials)...
February 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29339580/advantages-of-soft-subdural-implants-for-the-delivery-of-electrochemical-neuromodulation-therapies-to-the-spinal-cord
#15
Marco Capogrosso, Jérôme Gandar, Nathan Greiner, Eduardo Martin Moraud, Nikolaus Wenger, Polina Shkorbatova, Pavel E Мusienko, Ivan Minev, Stephanie P Lacour, Gregoire Courtine
We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or above the dura mater. Theoretically, the subdural location combines many advantages, including increased selectivity of electrical stimulation, lower stimulation thresholds, and targeted chemical stimulation through local drug delivery. However, these advantages have not been documented, nor have their functional impact been studied in-silico or in a relevant animal model of neurological disorders using a multimodal neural interface...
January 17, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29333355/bilateral-peripheral-nerve-field-stimulation-for-intractable-coccygeal-pain-a-case-study-using-dual-lead-intercommunication
#16
Michelle Granville, Patrick T Brennan, Robert E Jacobson
Coccygeal pain is a difficult chronic pain problem with mixed response to various treatments. This is a report of a case of coccygeal pain that after failing various conservative and interventional procedures over five years was evaluated with a temporary peripheral sacral fascial lead followed by implantation of bilateral sacral paramedian leads for peripheral nerve field stimulation (PNFS). This resulted in marked pain control and resumption of full activity. The visual analog scale (VAS) pain score improved from eight pre-implant to one after implant and has remained at that level in follow-up...
November 9, 2017: Curēus
https://www.readbyqxmd.com/read/29330489/decoding-hind-limb-kinematics-from-neuronal-activity-of-the-dorsal-horn-neurons-using-multiple-level-learning-algorithm
#17
Hamed Yeganegi, Yaser Fathi, Abbas Erfanian
Decoding continuous hind limb joint angles from sensory recordings of neural system provides a feedback for closed-loop control of hind limb movement using functional electrical stimulation. So far, many attempts have been done to extract sensory information from dorsal root ganglia and sensory nerves. In this work, we examine decoding joint angles trajectories from the single-electrode extracellular recording of dorsal horn gray matter of the spinal cord during passive limb movement in anesthetized cats. In this study, a processing framework based on ensemble learning approach is propose to combine firing rate (FR) and interspike interval (ISI) information of the neuronal activity...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29324503/%C3%AE-asarone-alleviated-chronic-constriction-injury-induced-neuropathic-pain-through-inhibition-of-spinal-endoplasmic-reticulum-stress-in-an-liver-x-receptor-dependent-manner
#18
Yulong Gui, Aiyuan Li, Jie Zhang, Guan Li, Xia Ruan, Qulian Guo, Wangyuan Zou
BACKGROUND: Neuropathic pain is an intractable and complex disease. Recent studies have shown a close relationship between endoplasmic reticulum (ER) stress and neuropathic pain. Here, we investigated the effect of α-asarone, an ER stress inhibitor, on chronic constriction injury (CCI)-induced neuropathic pain. METHODS: Two parts were included in this study. In part 1, rats were assigned to 7 groups: the sham group, the sham + α-asarone 20 mg/kg group, the CCI group, the CCI + vehicle group, the CCI + α-asarone 5 mg/kg group, the CCI + α-asarone 10 mg/kg group, and the CCI + α-asarone 20 mg/kg group...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29319015/a-practical-technique-in-laparoscopic-diaphragm-pacing-surgery-retrospective-analyse-of-43-patients
#19
Volkan Karacam, Aydin Sanli, Kemal Can Tertemiz, Ilknur Ulugun
INTRODUCTION: Diaphragm pacing stimulation (DPS) is a treatment method used in respiratory failure occurs in diseases such as high-level cervical spinal cord injury, central hypoventilation syndrome and amyotrophic lateral sclerosis. MATERIALS AND METHODS: A total of 43 patients, who had undergone DPS implantation surgery were evaluated retrospectively. The patients were divided into two groups according to the surgical technique (Group 1: classical surgical technic and Group 2: modified surgical technic) applied...
January 10, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29314501/peripheral-nerve-stimulation-for-chronic-shoulder-pain-a-proof-of-concept-anatomy-study
#20
Michael Gofeld, Anne Agur
OBJECTIVES: Although spinal cord and dorsal root ganglia stimulation may be effective for managing regional pain syndromes, a more targeted approach is perhaps more appealing for discrete anatomical structures. Chronic shoulder pain is a common musculoskeletal problem with significant socioeconomic impact. A peripheral nerve stimulation of the axillary and suprascapular nerves may prove to be effective as a long-term solution for this indication. In anticipation of the future experimental research and clinical utilization, a sound methodology for the lead placement was developed, and its feasibility is tested in a cadaveric study...
January 3, 2018: Neuromodulation: Journal of the International Neuromodulation Society
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