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https://www.readbyqxmd.com/read/28436245/book-review-pediatric-cochlear-implantation-learning-and-the-brain-kirk-nancy-m-young-karen-iler-eds-pediatric-cochlear-implantation-learning-and-the-brain-new-york-ny-springer-2016-365-pages-83-129-hardcover-122-kindle
#1
https://www.readbyqxmd.com/read/28434860/direct-brain-stimulation-modulates-encoding-states-and-memory-performance-in-humans
#2
Youssef Ezzyat, James E Kragel, John F Burke, Deborah F Levy, Anastasia Lyalenko, Paul Wanda, Logan O'Sullivan, Katherine B Hurley, Stanislav Busygin, Isaac Pedisich, Michael R Sperling, Gregory A Worrell, Michal T Kucewicz, Kathryn A Davis, Timothy H Lucas, Cory S Inman, Bradley C Lega, Barbara C Jobst, Sameer A Sheth, Kareem Zaghloul, Michael J Jutras, Joel M Stein, Sandhitsu R Das, Richard Gorniak, Daniel S Rizzuto, Michael J Kahana
People often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting, then decoded neural activity in later sessions in which we applied stimulation during learning...
April 13, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28434138/dynamic-epr-oximetry-of-changes-in-intracerebral-oxygen-tension-during-induced-thromboembolism
#3
Huagang Hou, Nadeem Khan, Sangeeta Gohain, Clifford J Eskey, Karen L Moodie, Kirk J Maurer, Harold M Swartz, Periannan Kuppusamy
Cerebral tissue oxygenation (oxygen tension, pO2) is a critical parameter that is closely linked to brain metabolism, function, and pathophysiology. In this work, we have used electron paramagnetic resonance oximetry with a deep-tissue multi-site oxygen-sensing probe, called implantable resonator, to monitor temporal changes in cerebral pO2 simultaneously at four sites in a rabbit model of ischemic stroke induced by embolic clot. The pO2 values in healthy brain were not significantly different among the four sites measured over a period of 4 weeks...
April 22, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28433987/radiofrequency-lesions-through-deep-brain-stimulation-electrodes-in-movement-disorders-case-report-and-review-of-the-literature
#4
Javier Pérez-Suárez, Cristina V Torres Díaz, Lydia López Manzanares, Marta Navas García, Jesús Pastor, Patricia Barrio Fernández, Rafael G de Sola
BACKGROUND: Although there are few reports of radiofrequency lesions performed through deep brain stimulation (DBS) electrodes in patients with movement disorders, experience with this method is scarce. METHODS: We present 2 patients who had been previously treated with DBS of subthalamic nuclei (STN) and the ventral intermediate (VIM) nucleus of the thalamus for Parkinson's disease and essential tremor, respectively, and underwent a radiofrequency lesion through their DBS electrodes after developing a hardware infection...
April 22, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28433446/functional-magnetic-resonance-imaging-to-assess-the-neurobehavioral-impact-of-dysphotopsia-with-multifocal-intraocular-lenses
#5
Andreia M Rosa, Ângela C Miranda, Miguel Patrício, Colm McAlinden, Fátima L Silva, Joaquim N Murta, Miguel Castelo-Branco
PURPOSE: To investigate the association between dysphotopsia and neural responses in visual and higher-level cortical regions in patients who recently received multifocal intraocular lens (IOL) implants. DESIGN: Cross-sectional study. PARTICIPANTS: Thirty patients 3 to 4 weeks after bilateral cataract surgery with diffractive IOL implantation and 15 age- and gender-matched control subjects. METHODS: Functional magnetic resonance imaging (fMRI) was performed when participants viewed low-contrast grating stimuli...
April 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28432654/laser-desorption-ionization-mass-spectrometric-imaging-of-endogenous-lipids-from-rat-brain-tissue-implanted-with-silver-nanoparticles
#6
Ludovic Muller, Kathrine Baldwin, Damon C Barbacci, Shelley N Jackson, Aurélie Roux, Carey D Balaban, Bruce E Brinson, Michael I McCully, Ernest K Lewis, J Albert Schultz, Amina S Woods
Mass spectrometry imaging (MSI) of tissue implanted with silver nanoparticulate (AgNP) matrix generates reproducible imaging of lipids in rodent models of disease and injury. Gas-phase production and acceleration of size-selected 8 nm AgNP is followed by controlled ion beam rastering and soft landing implantation of 500 eV AgNP into tissue. Focused 337 nm laser desorption produces high quality images for most lipid classes in rat brain tissue (in positive mode: galactoceramides, diacylglycerols, ceramides, phosphatidylcholines, cholesteryl ester, and cholesterol, and in negative ion mode: phosphatidylethanolamides, sulfatides, phosphatidylinositol, and sphingomyelins)...
April 21, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28431290/predicting-success-of-vagus-nerve-stimulation-vns-from-eeg-symmetry
#7
REVIEW
Janneke Hilderink, Marleen C Tjepkema-Cloostermans, Anita Geertsema, Janita Glastra-Zwiers, Cecile C de Vos
PURPOSE: Vagus nerve stimulation (VNS) has shown to be an effective treatment for drug resistant epilepsy, with achieving more than 50% seizure reduction in one third of the treated patients. In order to predict which patients will profit from VNS, we previously found that a low pairwise derived Brain Symmetry Index (pdBSI) could potentially predict good responders to VNS treatment. These findings however have to be validated before they can be generalized. METHODS: 39 patients (age 18-68 years) with medically intractable epilepsy who were referred for an implanted VNS system were included...
April 4, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28431064/is-mortality-a-useful-parameter-for-public-reporting-in-pacemaker-implantation-results-of-an-obligatory-external-quality-control-programme
#8
Bernd Nowak, Björn Misselwitz, Oliver Przibille, Rajendra H Mehta
Aims: To evaluate if public reporting of pacemaker implantation-associated mortality is meaningful in a large contemporary patient cohort. Methods and Results: The database of the obligatory external quality control programme in the Federal State of Hessen, Germany, of patients undergoing permanent pacemaker (PPM) implantation was evaluated retrospectively. We compared the baseline features of patients who died compared with those who did not during hospitalization after PPM...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28425028/energy-harvesting-from-cerebrospinal-fluid-pressure-fluctuations-for-self-powered-neural-implants
#9
Levent Beker, Arnau Benet, Ali Tayebi Meybodi, Ben Eovino, Albert P Pisano, Liwei Lin
In this paper, a novel method to generate electrical energy by converting available mechanical energy from pressure fluctuations of the cerebrospinal fluid within lateral ventricles of the brain is presented. The generated electrical power can be supplied to the neural implants and either eliminate their battery need or extend the battery lifespan. A diaphragm type harvester comprised of piezoelectric material is utilized to convert the pressure fluctuations to electrical energy. The pressure fluctuations cause the diaphragm to bend, and the strained piezoelectric materials generate electricity...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28424584/hif-1%C3%AE-overexpression-improves-transplanted-bone-mesenchymal-stem-cells-survival-in-rat-mcao-stroke-model
#10
Bingke Lv, Feng Li, Jianbang Han, Jie Fang, Limin Xu, Chengmei Sun, Tian Hua, Zhongfei Zhang, Zhiming Feng, Xiaodan Jiang
Bone mesenchymal stem cells (BMSCs) death after transplantation is a serious obstacle impacting on the outcome of cell therapy for cerebral infarction. This study was aimed to investigate whether modification of BMSCs with hypoxia-inducible factor 1α (Hif-1α) could enhance the survival of the implanted BMSCs. BMSCs were isolated from Wistar rats, and were infected with Hif-1α-GFP lentiviral vector or Hif-1α siRNA. The modified BMSCs were exposed to oxygen-glucose deprivation (OGD) condition, cellular viability and apoptosis were then assessed...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28424401/-the-map-of-auditory-function
#11
So Fujimoto, Yutaka Komura
Brodmann areas 41 and 42 are located in the superior temporal gyrus and regarded as auditory cortices. The fundamental function in audition is frequency analysis; however, the findings on tonotopy maps of the human auditory cortex were not unified until recently when they were compared to the findings on inputs and outputs of the monkey auditory cortex. The auditory cortex shows plasticity after conditioned learning and surgery of cochlear implant. It is also involved in speech perception, music appreciation, and auditory hallucination in schizophrenia through interactions with other brain areas, such as the thalamus, frontal cortex, and limbic systems...
April 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28422663/a-neural-probe-with-up-to-966-electrodes-and-up-to-384-configurable-channels-in-0-13-%C3%AE-m-soi-cmos
#12
Carolina Mora Lopez, Jan Putzeys, Bogdan Cristian Raducanu, Marco Ballini, Shiwei Wang, Alexandru Andrei, Veronique Rochus, Roeland Vandebriel, Simone Severi, Chris Van Hoof, Silke Musa, Nick Van Helleputte, Refet Firat Yazicioglu, Srinjoy Mitra
In vivo recording of neural action-potential and local-field-potential signals requires the use of high-resolution penetrating probes. Several international initiatives to better understand the brain are driving technology efforts towards maximizing the number of recording sites while minimizing the neural probe dimensions. We designed and fabricated (0.13- μm SOI Al CMOS) a 384-channel configurable neural probe for large-scale in vivo recording of neural signals. Up to 966 selectable active electrodes were integrated along an implantable shank (70 μm wide, 10 mm long, 20  μm thick), achieving a crosstalk of [Formula: see text] dB...
April 14, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28422529/implant-compositions-for-the-unidirectional-delivery-of-drugs-to-the-brain
#13
Michael McGinity, John Floyd, James McGinity, Feng Zhang
The overall objective of this study was to design and characterize the properties of a bioadhesive trilayer sustained-release implant device for the unidirectional local delivery of anticancer compounds to the brain following the removal of glioblastoma multiforme tumors. Using acetaminophen as a model drug compound, we compressed trilayer wafers that contained (a) a bioadhesive layer, (b) a drug layer that contained a lipid and a pore-forming hydrophilic polymer, and (c) a third layer comprising a lipid substance...
April 19, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28419303/tumor-microtubes-convey-resistance-to-surgical-lesions-and-chemotherapy-in-gliomas
#14
Sophie Weil, Matthias Osswald, Gergely Solecki, Julia Grosch, Erik Jung, Dieter Lemke, Miriam Ratliff, Daniel Hänggi, Wolfgang Wick, Frank Winkler
Background: Primary and adaptive resistance against chemo- and radiotherapy, and local recurrence after surgery limit the benefits from these standard treatments in glioma patients. Recently we found that glioma cells can extend ultra-long membrane protrusions, "tumor microtubes" (TMs), for brain invasion, proliferation, and interconnection of single cells to a syncytium that is resistant to radiotherapy. We wondered whether TMs also convey resistance to the other two standard treatment modalities...
April 17, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28418061/self-powered-electrochemical-systems-as-neurochemical-sensors-toward-self-triggered-in-vivo-analysis-of-brain-chemistry
#15
Fei Wu, Ping Yu, Lanqun Mao
Real-time in vivo analysis of neurochemical dynamics has great physiological and pathological implications for a full understanding of the brain. Self-powered electrochemical systems (SPESs) built on galvanic cell configurations bear the advantages of easy miniaturization for implantation and no interference to electric activities of neurons over traditional externally-powered electrochemical sensors for self-triggered in vivo analysis. However, this is still a new concept for in vivo neurochemical sensing with few implanted examples reported so far...
April 18, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28416595/nonsinusoidal-beta-oscillations-reflect-cortical-pathophysiology-in-parkinson-s-disease
#16
Scott R Cole, Roemer van der Meij, Erik J Peterson, Coralie de Hemptinne, Philip A Starr, Bradley Voytek
Oscillations in neural activity play a critical role in neural computation and communication. There is intriguing new evidence that the nonsinusoidal features of the oscillatory waveforms may inform underlying physiological and pathophysiological characteristics. Time-domain waveform analysis approaches stand in contrast to traditional Fourier-based methods, which alter or destroy subtle waveform features. Recently it has been shown that the waveform features of oscillatory beta (13-30 Hz) events-a prominent motor cortical oscillation-may reflect near-synchronous excitatory synaptic inputs onto cortical pyramidal neurons...
April 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28416488/activation-of-notch-signaling-by-tenascin-c-promotes-growth-of-human-brain-tumor-initiating-cells
#17
Susobhan Sarkar, Reza Mirzaei, Franz J Zemp, Wei Wu, Donna L Senger, Stephen M Robbins, V Wee Yong
Elevated NOTCH signaling is implicated in tumorigenesis. The brain tumor- initiating cells (BTICs) present in malignant glioma exhibit elevated NOTCH activity but the mechanism of this activation is unknown. Here, we provide evidence that tenascin-C (TNC), an extracellular matrix protein prominent in malignant glioma, increases NOTCH activity in BTICs to promote their growth. We demonstrate the proximal localization of TNC and BTICs in human glioblastoma specimens, and in the brains of mice implanted with human BTIC intracranial xenografts...
April 17, 2017: Cancer Research
https://www.readbyqxmd.com/read/28412969/engagement-of-cellular-prion-protein-with-the-co-chaperone-hsp70-90-organizing-protein-regulates-the-proliferation-of-glioblastoma-stem-like-cells
#18
Rebeca Piatniczka Iglesia, Mariana Brandão Prado, Lilian Cruz, Vilma Regina Martins, Tiago Góss Santos, Marilene Hohmuth Lopes
BACKGROUND: Glioblastoma (GBM), a highly aggressive brain tumor, contains a subpopulation of glioblastoma stem-like cells (GSCs) that play roles in tumor maintenance, invasion, and therapeutic resistance. GSCs are therefore a promising target for GBM treatment. Our group identified the cellular prion protein (PrP(C)) and its partner, the co-chaperone Hsp70/90 organizing protein (HOP), as potential target candidates due to their role in GBM tumorigenesis and in neural stem cell maintenance...
April 17, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28412968/interleukin-1-primes-human-mesenchymal-stem-cells-towards-an-anti-inflammatory-and-pro-trophic-phenotype-in-vitro
#19
Elena Redondo-Castro, Catriona Cunningham, Jonjo Miller, Licia Martuscelli, Sarah Aoulad-Ali, Nancy J Rothwell, Cay M Kielty, Stuart M Allan, Emmanuel Pinteaux
BACKGROUND: Inflammation is a key contributor to central nervous system (CNS) injury such as stroke, and is a major target for therapeutic intervention. Effective treatments for CNS injuries are limited and applicable to only a minority of patients. Stem cell-based therapies are increasingly considered for the treatment of CNS disease, because they can be used as in-situ regulators of inflammation, and improve tissue repair and recovery. One promising option is the use of bone marrow-derived mesenchymal stem cells (MSCs), which can secrete anti-inflammatory and trophic factors, can migrate towards inflamed and injured sites or can be implanted locally...
April 17, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28412733/prevention-of-tumor-seeding-during-needle-biopsy-by-chemotherapeutic-releasing-gelatin-sticks
#20
Ren-Yuan Bai, Verena Staedtke, Xuewei Xia, Gregory J Riggins
Needle biopsy is an indispensable diagnostic tool in obtaining tumor tissue for diagnostic examination. Tumor cell seeding in the needle track during percutaneous needle biopsies has been reported for various types of cancers. The mechanical force of the biopsy both directly displaces the malignant cells and causes bleeding and fluid movement that can further disseminate cells. To prevent the risk of tumor cell seeding during biopsy, we developed a gelatin stick loaded with chemotherapeutics such as doxorubicin (DXR) that was inserted into the biopsy canal...
February 16, 2017: Oncotarget
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