keyword
MENU ▼
Read by QxMD icon Read
search

Brain implants

keyword
https://www.readbyqxmd.com/read/28634306/representations-of-time-varying-cochlear-implant-stimulation-in-auditory-cortex-of-awake-marmosets-callithrix-jacchus
#1
Luke A Johnson, Charles C Della Santina, Xiaoqin Wang
Electrical stimulation of the auditory periphery organ by cochlear implant (CI) generates highly synchronized inputs to the auditory system. It has long been thought such inputs would lead to highly synchronized neural firing along the ascending auditory pathway. However, neurophysiological studies with hearing animals have shown that the central auditory system progressively converts temporal representations of time-varying sounds to firing rate-based representations. It is not clear whether this coding principle also applies to highly synchronized CI inputs...
June 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28631870/thalamic-deep-brain-stimulation-for-neuropathic-pain-efficacy-at-three-years-follow-up
#2
Vasco Abreu, Rui Vaz, Virgínia Rebelo, Maria José Rosas, Clara Chamadoira, Martin J Gillies, Tipu Z Aziz, Erlick A C Pereira
OBJECT: Chronic neuropathic pain is estimated to affect 3-4.5% of the worldwide population, posing a serious burden to society. Deep Brain Stimulation (DBS) is already established for movement disorders and also used to treat some "off-label" conditions. However, DBS for the treatment of chronic, drug refractory, neuropathic pain, has shown variable outcomes with few studies performed in the last decade. Thus, this procedure has consensus approval in parts of Europe but not the USA. This study prospectively evaluated the efficacy at three years of DBS for neuropathic pain...
June 20, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28631360/reduced-cell-attachment-to-poly-2-hydroxyethyl-methacrylate-coated-ventricular-catheters-in-vitro
#3
Brian W Hanak, Chia-Yun Hsieh, William Donaldson, Samuel R Browd, Kenneth K S Lau, William Shain
The majority of patients with hydrocephalus are dependent on ventriculoperitoneal shunts for diversion of excess cerebrospinal fluid. Unfortunately, these shunts are failure-prone and over half of all life-threatening pediatric failures are caused by obstruction of the ventricular catheter by the brain's resident immune cells, reactive microglia and astrocytes. Poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels are widely used for biomedical implants. The extreme hydrophilicity of PHEMA confers resistance to protein fouling, making it a strong candidate coating for ventricular catheters...
June 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28631129/optimizing-the-deep-brain-stimulation-care-pathway-in-patients-with-parkinson-s-disease
#4
N J Thomas, P Mertens, T Danaila, G Polo, H Klinger, E Broussolle, S Thobois
Management of Parkinson's disease (PD) using deep brain stimulation (DBS) requires complex care in specialized, multidisciplinary centers. A well-organized, efficient patient flow is crucial to ensure that eligible patients can quickly access DBS. Delays or inefficiencies in patient care may impact a center's ability to meet demand, creating a capacity bottleneck. Analysis of the current practices within a center may help identify areas for improvement. After external audit of the DBS workflow of the Lyon Neurological Hospital and comparison with other European centers, manageable steps were suggested to restructure the care pathway...
June 19, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28628137/-antagonistic-effect-of-quercetin-on-pm2-5-toxicity-in-the-rat-s-embryonic-development-in-vitro
#5
A Q Fan, J Q Feng, W Liu, M J Zhang, T Liu, Y L Zhou, Y J Xu
OBJECTIVE: To explore the antagonistic effect of quercetin on fine particulate matter (PM2.5)-induced embryonic developmental toxicity in vitro. METHODS: PM2.5 was collected on glass fiber filters by PM2.5 samplers during the heating period of Dec. 2015 to Mar. 2016 in an area of Haidian District, Beijing City. The sampled filters were cut into 1 cm×3 cm pieces followed by sonication. The PM2.5 suspension was filtered into a 10 cm glass dish through 8 layers of sterile carbasus and stored at -80 °C until freeze drying...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28628101/dynamic-illumination-of-spatially-restricted-or-large-brain-volumes-via-a-single-tapered-optical-fiber
#6
Ferruccio Pisanello, Gil Mandelbaum, Marco Pisanello, Ian A Oldenburg, Leonardo Sileo, Jeffrey E Markowitz, Ralph E Peterson, Andrea Della Patria, Trevor M Haynes, Mohamed S Emara, Barbara Spagnolo, Sandeep Robert Datta, Massimo De Vittorio, Bernardo L Sabatini
Optogenetics promises precise spatiotemporal control of neural processes using light. However, the spatial extent of illumination within the brain is difficult to control and cannot be adjusted using standard fiber optics. We demonstrate that optical fibers with tapered tips can be used to illuminate either spatially restricted or large brain volumes. Remotely adjusting the light input angle to the fiber varies the light-emitting portion of the taper over several millimeters without movement of the implant...
June 19, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28623639/anemia-after-continuous-flow-left-ventricular-assist-device-implantation-characteristics-and-implications
#7
Javier Amione-Guerra, Ana S Cruz-Solbes, Arvind Bhimaraj, Barry H Trachtenberg, Sai R Pingali, Jerry D Estep, Myung H Park, Ashrith Guha
BACKGROUND: Anemia is common in patients with heart failure and is associated with adverse outcomes. Management of anemia in CF-LVAD patients is not well studied. Our purpose is to characterize and identify the etiology of anemia in CF-LVAD patients. Secondary objectives are to describe the effect of CF-LVAD on pre-existing anemia and assess its impact after CF-LVAD support. METHODS: Cross-sectional study from January to July 2015 of ambulatory patients supported with a CF-LVAD for at least 6-months that presented with hemoglobin <12 g/dL and no recent gastrointestinal bleeding...
June 14, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28623323/rufy3-interaction-with-foxk1-promotes-invasion-and-metastasis-in-colorectal-cancer
#8
Ruyi Xie, Jing Wang, Xuehua Liu, Liqing Wu, Hui Zhang, Weimei Tang, Yueqiao Li, Li Xiang, Ying Peng, Xiaoting Huang, Yang Bai, Guangnan Liu, Aimin Li, Yadong Wang, Ye Chen, Yuexin Ren, Guoxin Li, Wei Gong, Side Liu, Jide Wang
RUFY3 is highly expressed in brain tissue and has a role in neuronal development. Transcriptional factor FOXK1 is involved in cell growth and metabolism. We knew that RUFY3 or FOXK1 has been correlated with the malignant of tumor cells. However, the role of these molecules in colorectal cancer (CRC) progression remains unknown. We investigated the protein expression levels by Western blot, immunofluorescence and immunohistochemistry analyses. The migration and invasive abilities of CRC cells were assessed using shRNA-mediated inhibition in vitro and in vivo...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28623139/the-co-expression-of-neogenin-with-sox2-in-hippocampal-neurons
#9
Namgue Hong, Mi-Hye Kim, Churl K Min, Hee Jung Kim, Jae Ho Lee
Dementia has been shown to be closely related with neuronal degeneration and/or a decrease in the activity of neural stem cells in many brain regions, including the hippocampus. It has been recently established that Neogenin is involved in the cell fate determination by regulating Oct3/4, SOX and Nanog, notable embryonic cell markers, expressions in pre-implantation mouse embryos. Further, Neogenin expression at both mRNA and protein levels is manifest in many brain regions in mice, but it remains unclear whether Neogenin expression is prerequisite for the maintenance of neural stem cells, particularly, playing a critical role in the hippocampus, a brain region known to be involved in memory generation and consolidation...
June 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28616842/characterization-of-magneto-endosymbionts-as-mri-cell-labeling-and-tracking-agents
#10
Kimberly D Brewer, Ryan Spitler, Kayla R Lee, Andrea C Chan, Joyce C Barrozo, Abdul Wakeel, Chandler S Foote, Steven Machtaler, James Rioux, Juergen K Willmann, Papia Chakraborty, Bradley W Rice, Christopher H Contag, Caleb B Bell, Brian K Rutt
PURPOSE: Magneto-endosymbionts (MEs) show promise as living magnetic resonance imaging (MRI) contrast agents for in vivo cell tracking. Here we characterize the biomedical imaging properties of ME contrast agents, in vitro and in vivo. PROCEDURES: By adapting and engineering magnetotactic bacteria to the intracellular niche, we are creating magneto-endosymbionts (MEs) that offer advantages relative to passive iron-based contrast agents (superparamagnetic iron oxides, SPIOs) for cell tracking...
June 14, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28615151/parkinson-s-disease-patient-preference-and-experience-with-various-methods-of-dbs-lead-placement
#11
Sara C LaHue, Jill L Ostrem, Nicholas B Galifianakis, Marta San Luciano, Nathan Ziman, Sarah Wang, Caroline A Racine, Philip A Starr, Paul S Larson, Maya Katz
INTRODUCTION: Physiology-guided deep brain stimulation (DBS) surgery requires patients to be awake during a portion of the procedure, which may be poorly tolerated. Interventional MRI-guided (iMRI) DBS surgery was developed to use real-time image guidance, obviating the need for patients to be awake during lead placement. METHODS: All English-speaking adults with PD who underwent iMRI DBS between 2010 and 2014 at our Center were invited to participate. Subjects completed a structured interview that explored perioperative preferences and experiences...
April 17, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28614710/anterior-cingulate-cortex-modulation-of-the-ventral-tegmental-area-in-an-effort-task
#12
Thomas W Elston, David K Bilkey
Information gained during goal pursuit motivates adaptive behavior. The anterior cingulate cortex (ACC) supports adaptive behavior, but how ACC signals are translated into motivational signals remains unclear. Rats with implants in the ACC and ventral tegmental area (VTA), a dopaminergic brain area implicated in motivation, were trained to run laps around a rectangular track for a fixed reward, where each lap varied in physical effort (a 30-cm climbable barrier). Partial directed coherence analysis of local field potentials revealed that ACC theta (4-12 Hz) activity increased as rats entered the barrier-containing region of the maze in trials when the barrier was absent and predicted similar changes in VTA theta activity...
June 13, 2017: Cell Reports
https://www.readbyqxmd.com/read/28612755/learning-to-see-again-biological-constraints-on-cortical-plasticity-and-the-implications-for-sight-restoration-technologies
#13
Michael Beyeler, Ariel Rokem, Geoffrey Boynton, Ione Fine
The "bionic eye" - so long a dream of the future - is finally becoming a reality with retinal prostheses available to patients in both the US and Europe. However, clinical experience with these implants has made it apparent that the vision provided by these devices differs substantially from normal sight. Consequently, the ability to learn to make use of this abnormal retinal input plays a critical role in whether or not some functional vision is successfully regained. The goal of the present review is to summarize the vast basic science literature on developmental and adult cortical plasticity with an emphasis on how this literature might relate to the field of prosthetic vision...
June 14, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28607825/cranioplasty-indications-procedures-and-outcome-an-institutional-experience
#14
Syed M Andrabi, Arif H Sarmast, Altaf R Kirmani, Abdul R Bhat
BACKGROUND: Cranioplasty, the repair of a skull vault defect by insertion of an object (bone or nonbiological materials such as metal or plastic plates), is a well-known procedure in modern neurosurgery. Brain protection and cosmetic aspects are the major indications of cranioplasty. A retroprospective study was conducted for evaluating the indications, materials used, complications, and outcome of cranioplasty. METHODS: This study was prospective from August 2013 to September 2015 and retrospective from August 2010 to July 2013...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28605391/intranasal-delivery-of-therapeutic-stem-cells-to-glioblastoma-in-a-mouse-model
#15
Dou Yu, Gina Li, Maciej S Lesniak, Irina V Balyasnikova
The intrinsic tropism towards brain malignancies renders stem cells as promising carriers of therapeutic agents against malignant tumors. The delivery of therapeutic stem cells via the intranasal route is a recently discovered alternative strategy, with strong potential for clinical translation, due to its non-invasive nature compared to intracranial implantation or delivery via systemic routes. The lack of blood brain barrier further strengthens the therapeutic potential of stem cells undergoing intranasal brain entry...
June 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28605376/anatomically-inspired-three-dimensional-micro-tissue-engineered-neural-networks-for-nervous-system-reconstruction-modulation-and-modeling
#16
Laura A Struzyna, Dayo O Adewole, Wisberty J Gordián-Vélez, Michael R Grovola, Justin C Burrell, Kritika S Katiyar, Dmitriy Petrov, James P Harris, D Kacy Cullen
Functional recovery rarely occurs following injury or disease-induced degeneration within the central nervous system (CNS) due to the inhibitory environment and the limited capacity for neurogenesis. We are developing a strategy to simultaneously address neuronal and axonal pathway loss within the damaged CNS. This manuscript presents the fabrication protocol for micro-tissue engineered neural networks (micro-TENNs), implantable constructs consisting of neurons and aligned axonal tracts spanning the extracellular matrix (ECM) lumen of a preformed hydrogel cylinder hundreds of microns in diameter that may extend centimeters in length...
May 31, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28605362/recording-eeg-in-freely-moving-neonatal-rats-using-a-novel-method
#17
Qing-Wei Huo, Sidra Tabassum, Afzal Ali Misrani, Cheng Long
EEG is a useful method to detect electrical activity in the brain. Moreover, it is a widely used diagnostic tool for various neurological conditions, such as epilepsy and neurodegenerative disorders. However, it is technically difficult to obtain EEG recordings in neonates as it requires specialized handling and great care. Here, we present a novel method to record EEG in neonatal rat pups (P8-P15). We designed a simple and reliable electrode using computer pin loci; it can be easily implanted into the skull of a rat pup to record high-quality EEG signals in the normal and epileptic brain...
May 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28604578/long-term-outcomes-of-cochlear-implantation-in-children-with-congenital-cytomegalovirus-infection
#18
Haruo Yoshida, Haruo Takahashi, Yukihiko Kanda, Kyoko Kitaoka, Minoru Hara
OBJECTIVE: To investigate the role of the developmental delay often observed in children with congenital cytomegalovirus (CMV) infection on the improvement of language understanding after cochlear implantation (CI). STUDY DESIGN: Retrospective chart review. PATIENTS: Sixteen children with severe and/or profound hearing loss due to congenital CMV infection (CMV group) and 107 congenitally deaf children (168 ears) without CMV infection as the cause of deafness (non-CMV group)...
June 9, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28602745/effect-of-systemic-estradiol-administration-on-tail-hiding-behavior-and-cfos-expression-of-brain-areas-in-female-rats-exposed-to-cold-environment
#19
Yuki Uchida, Kei Nagashima, Kazunari Yuri
Rats place their tails underneath their body trunks in the cold (tail-hiding behavior), which is a new behavioral indicator of thermoregulation in the cold. The aim of the present study was to elucidate the effect of estradiol (E2) on tail-hiding behavior and neural activity in brain areas in the cold. Ovariectomized rats were implanted with a silastic tube with or without E2 underneath the dorsal skin (E2 (-) and E2 (+) groups), and exposed to 27°C, 16°C, and 10°C for 2 hours with continuous body temperature (Tb), tail skin temperature (Ttail), and behavioral measurements...
June 8, 2017: Brain Research
https://www.readbyqxmd.com/read/28599089/initial-graft-size-and-not-the-innate-immune-response-limit-survival-of-engrafted-neural-stem-cells
#20
Stefanie Vogel, Markus Aswendt, Melanie Nelles, Nadine Henn, Gabriele Schneider, Mathias Hoehn
Transplantation of neural stem cells (NSCs) appears as the most promising regenerative therapy for a variety of neurological disorders. Nevertheless, NSC engraftment is limited by the number of surviving cells. To maximize stem cell-mediated effects, timing of implantation and cell number have to be precisely evaluated. Here, we optimized a transgenic murine NSC line for high expression levels of the imaging reporters Luc2 and copGFP. NSCs of 150 000, 75 000, 15 000, or 1 500 cells or Hanks buffered salt solution were implanted into the striatum of nude mice...
June 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
keyword
keyword
108385
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"