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platelets and surgery

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https://www.readbyqxmd.com/read/28922227/incidence-and-risk-factors-of-coagulation-profile-derangement-after-liver-surgery-implications-for-the-use-of-epidural-analgesia-a-retrospective-cohort-study
#1
Pierre Jacquenod, Grégoire Wallon, Mathieu Gazon, Benjamin Darnis, Pierre Pradat, Victor Virlogeux, Olivier Farges, Frédéric Aubrun
BACKGROUND: Hepatic surgery is a major abdominal surgery. Epidural analgesia may decrease the incidence of postoperative morbidities. Hemostatic disorders frequently occur after hepatic resection. Insertion or withdrawal (whether accidental or not) of an epidural catheter during coagulopathic state may cause an epidural hematoma. The aim of the study is to determine the incidence of coagulopathy after hepatectomy, interfering with epidural catheter removal, and to identify the risk factors related to coagulopathy...
September 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28922205/impact-of-advanced-age-on-survival-in-patients-undergoing-resection-of-hepatocellular-carcinoma-report-of-a-japanese-nationwide-survey
#2
Masaki Kaibori, Kengo Yoshii, Isao Yokota, Kiyoshi Hasegawa, Fumio Nagashima, Shoji Kubo, Masanori Kon, Namiki Izumi, Masumi Kadoya, Masatoshi Kudo, Takashi Kumada, Michiie Sakamoto, Osamu Nakashima, Yutaka Matsuyama, Tadatoshi Takayama, Norihiro Kokudo
OBJECTIVE: The impact of age on survival after hepatic resection for hepatocellular carcinoma (HCC) has not been thoroughly examined. We reviewed the data of a nationwide follow-up survey to determine the outcomes of hepatectomy for HCC in elderly patients. BACKGROUND: Management of malignant diseases in elderly patients has become a global clinical issue because of the increased life expectancy worldwide. Advancements in surgical techniques and perioperative management have reduced age-related contraindications for liver surgery...
September 15, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28919069/impact-of-discontinuation-of-antiplatelet-therapy-prior-to-isolated-valve-and-combined-coronary-artery-bypass-graft-and-valve-procedures-on-short-and-intermediate-term-outcomes
#3
James Meneguzzi, Matthew Kilpin, Ying Yan Zhu, Atsuo Doi, Christopher Reid, Lavinia Tran, Philip Hayward, Julian Smith
BACKGROUND: A change in cardiac surgery practice over the past decade has seen an increase in urgent or inpatient referrals for surgery, with antiplatelet therapy often continued up until surgery. This study aims to identify the optimal timing for administration of aspirin to minimise risk of perioperative morbidity and mortality. METHODS: From a prospectively compiled database collected by the Australian and New Zealand Society of Cardiac and Thoracic Surgeons, we identified 8,294 patients undertaking combined CABG and valve or isolated valve procedures while discontinuing aspirin...
September 1, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28918242/predictive-value-of-thomsen-friedenreich-antigen-activation-for-streptococcus-pneumoniae-infection-and-severity-in-pediatric-lobar-pneumonia
#4
Chia-Jung Chang, Nan-Chang Chiu, Fu-Yuan Huang, Daniel Tsung-Ning Huang, Lung Chang, Ching-Ying Huang, Yen-Hsin Kung, Hsin Chi
BACKGROUND: Most cases of complicated pneumonia in children are caused by pneumococcal infections. Thomsen-Friedenreich antigen (TA) is present on erythrocytes, platelets and glomeruli, and it can be activated during pneumococcal infection. The aim of this study was to investigate the predictive value of TA activation for pneumococcal infection and association with the severity of complicated pneumonia. MATERIALS AND METHODS: Patients with lobar pneumonia were routinely tested for TA at the Department of Pediatrics, Mackay Memorial Hospital from January 2010 to December 2015...
September 2, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28915696/top2a-ggh-and-pecam1-are-associated-with-hematogenous-lymph-node-and-peritoneal-recurrence-in-stage-ii-iii-gastric-cancer-patients-enrolled-in-the-acts-gc-study
#5
Masanori Terashima, Wataru Ichikawa, Atsushi Ochiai, Koji Kitada, Issei Kurahashi, Shinichi Sakuramoto, Hitoshi Katai, Takeshi Sano, Hiroshi Imamura, Mitsuru Sasako
BACKGROUND: To identify factors related to relapse sites, we carried out an exploratory biomarker analysis of data from the Adjuvant Chemotherapy Trial of TS-1 for Gastric Cancer study, which is a randomized, controlled trial comparing postoperative adjuvant S-1 therapy with surgery alone in 1,059 patients with stage II/III gastric cancer. PATIENTS AND METHODS: Surgical specimens from 829 patients were retrospectively examined, and 63 genes involved in a variety of biological processes were analyzed by quantitative real-time PCR...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915691/preoperative-monocyte-lymphocyte-and-neutrophil-lymphocyte-but-not-platelet-lymphocyte-ratios-are-predictive-of-clinical-outcomes-in-resected-patients-with-non-metastatic-siewert-type-ii-iii-adenocarcinoma-of-esophagogastric-junction-a-prospective-cohort-study
#6
Jia-Wei Zhang, Lei Huang, A-Man Xu
AIMS: To propectively reveal the clinicopathological and prognostic significances of monocyte-lymphocyte ratio (MLR), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in resected patients with non-metastatic Siewert type II/III adenocarcinoma of esophagogastric junction (AEG). METHODS: A total of 611 patients diagnosed with Siewert type II/III AEG and undergoing surgery between 2006 and 2011 were prospectively followed-up until April 2016. Associations between preoperative peripheral MLR, NLR, and PLR and clinicopathological parameters were quantified using the multivariate Logistic regression model with adjustment...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28903023/platelet-to-lymphocyte-ratio-in-biliary-tract-cancer-review-and-meta-analysis
#7
REVIEW
Lin-Hua Zhou, Xiao-Feng Luo
BACKGROUND: The platelet to lymphocyte ratio (PLR) has been found to predict clinical outcomes in multiple malignancies. The aim of this study was to assess the prognostic value of pretreatment PLR in biliary tract cancer (BTC). METHODS: We searched the MEDLINE, EMBASE, and Cochrane databases to identify studies evaluating the prognostic significance of pretreatment PLR in BTC. The end points were overall survival (OS), recurrence-free survival (RFS). Pooled hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed-effects/random-effects models...
September 10, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28894692/case-report-infection-of-total-knee-arthroplasty-treated-with-one-stage-surgery-and-linezolid
#8
Adriana Macedo Dell'Aquila, Cesar Janovsky, Moises Cohen
Staphylococcus spp meticillin resistant infection can be treated with Linezolid. This is a case report of an orthopaedic implant infection in a 60 year-old male treated orally with Linezolid and Rifampicin for three months after one-stage arthroplasty. This is possible provided that platelet count is closely monitored throughout the course of treatment.
2017: Journal of bone and joint infection
https://www.readbyqxmd.com/read/28894464/inflammatory-markers-as-prognostic-factors-of-survival-in-patients-affected-by-hepatocellular-carcinoma-undergoing-transarterial-chemoembolization
#9
A Rebonato, L Graziosi, D Maiettini, E Marino, V De Angelis, L Brunese, S Mosca, G Metro, M Rossi, G Orgera, M Scialpi, A Donini
INTRODUCTION: Transarterial chemoembolization (TACE) is a good choice for hepatocellular carcinoma (HCC) treatment when surgery and liver transplantation are not feasible. Few studies reported the value of prognostic factors influencing survival after chemoembolization. In this study, we evaluated whether preoperative inflammatory factors such as neutrophil to lymphocyte ratio and platelet to lymphocyte ratio affected our patient survival when affected by hepatocellular carcinoma. METHODS: We retrospectively evaluated a total of 72 patients with hepatocellular carcinoma that underwent TACE...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28893049/comparative-evaluation-of-the-efficacy-of-bioactive-ceramic-composite-granules-alone-and-in-combination-with-platelet-rich-fibrin-in-the-treatment-of-mandibular-class-ii-furcation-defects-a-clinical-and-radiographic-study
#10
Hima S Lohi, Dilip G Nayak, Ashita S Uppoor
INTRODUCTION: Predictable closure of furcation defects with bone grafts, Guided Tissue Regeneration (GTR) and a combination of the two has remained an elusive goal so far. Hence, evaluation of biomimetic agents as candidate technologies for periodontal regeneration merit due consideration. In this study, Choukroun's Platelet Rich Fibrin (PRF), a second generation platelet concentrate, is combined with bone graft to examine if the addition enhances the therapeutic potential of bone graft in the management of Class II furcation defects...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28890257/effects-of-pdgf-bb-delivery-from-heparinized-collagen-sutures-on-the-healing-of-lacerated-chicken-flexor-tendon-in-vivo
#11
Mousa Younesi, Derrick M Knapik, Jameson Cumsky, Baris Ozgur Donmez, Ping He, Anowarul Islam, Greg Learn, Philip McClellan, Michael Bohl, Robert J Gillespie, Ozan Akkus
Flexor tendon lacerations are traditionally repaired by using non-absorbable monofilament sutures. Recent investigations have explored to improve the healing process by growth factor delivery from the sutures. However, it is difficult to conjugate growth factors to nylon or other synthetic sutures. This study explores the performance of a novel electrochemically aligned collagen suture in a flexor tendon repair model with and without platelet derived growth factor following complete tendon laceration in vivo...
September 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28890151/when-to-perform-preoperative-bone-scintigraphy-for-kidney-cancer-staging-indications-for-preoperative-bone-scintigraphy
#12
Alessandro Larcher, Fabio Muttin, Nicola Fossati, Paolo Dell'Oglio, Ettore Di Trapani, Armando Stabile, Francesco Ripa, Francesco Trevisani, Cristina Carenzi, Maria Picchio, Alberto Briganti, Andrea Salonia, Alexandre Mottrie, Roberto Bertini, Francesco Montorsi, Umberto Capitanio
OBJECTIVES: To identify an objective and reproducible strategy for preoperative staging bone scintigraphy [BS] in patients diagnosed with renal cell carcinoma [RCC], since in absence of objective criteria, the decision to perform preoperative BS remains a subjective practice. METHODS: 2,008 RCC patients treated with surgery and prospectively included into an institutional database. The study outcome was presence of one or more bone lesions suspicious for metastases at staging BS...
September 7, 2017: Urology
https://www.readbyqxmd.com/read/28887865/plasma-rich-plasma-the-ultimate-secret-for-youthful-skin-elixir-and-hair-growth-triggering
#13
REVIEW
Ebtisam Elghblawi
The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage...
September 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28887717/prognostic-importance-of-temozolomide-induced-neutropenia-in-glioblastoma-idh-wildtype-patients
#14
Taiichi Saito, Kazuhiko Sugiyama, Seiji Hama, Fumiyuki Yamasaki, Takeshi Takayasu, Ryo Nosaka, Yoshihiro Muragaki, Takakazu Kawamata, Kaoru Kurisu
Standard treatment for patients with primary glioblastoma (GBM) includes surgery, radiotherapy, and concomitant and adjuvant temozolomide (TMZ). Recent reports have demonstrated that TMZ-induced myelosuppression correlates with survival in patients with GBM. However, those results were evaluated before the 2016 revision of the World Health Organization classification. This study examined whether myelosuppression during concomitant TMZ phase correlates with prognosis in GBM, IDH-wildtype patients. We examined circulating blood cell counts in 50 patients with GBM, IDH-wildtype who received the standard treatment protocol between August 2005 and November 2015...
September 9, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28885122/clinicopathological-variables-of-sporadic-schwannomas-of-peripheral-nerve-in-291-patients-and-expression-of-biologically-relevant-markers
#15
Eric D Young, Davis Ingram, William Metcalf-Doetsch, Dilshad Khan, Ghadah Al Sannaa, Francois Le Loarer, Alexander J F Lazar, John Slopis, Keila E Torres, Dina Lev, Raphael E Pollock, Ian E McCutcheon
OBJECTIVE While sporadic peripheral schwannomas (SPSs) are generally well treated with surgery, their biology is not well understood. Consequently, treatment options are limited. The aim of this study was to provide a comprehensive description of SPS. The authors describe clinicopathological features and treatment outcomes of patients harboring these tumors, and they assess expression of biomarkers using a clinically annotated tissue microarray. Together, these data give new insight into the biology and management of SPS...
September 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28883474/plasma-exosomal-mir-223-expression-regulates-inflammatory-responses-during-cardiac-surgery-with-cardiopulmonary-bypass
#16
Kin-Shing Poon, Kalaiselvi Palanisamy, Shih-Sheng Chang, Kuo-Ting Sun, Kuen-Bao Chen, Ping-Chun Li, Tso-Chou Lin, Chi-Yuan Li
Cardiopulmonary bypass (CPB) induces inflammatory responses, and effective endogenous homeostasis is important for preventing systemic inflammation. We assessed whether plasma exosomal microRNAs in patients undergoing cardiac surgery with CPB are involved in the regulation of inflammatory responses. Plasma samples were isolated from CPB patients (n = 21) at 5 specified time points: pre-surgery, pre-CPB and 2 hours (h), 4 h and 24 h after CPB began. Plasma TNF-α expression was increased after CPB began compared to that in the pre-surgery samples...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28876625/to-activate-or-not-to-activate-the-controversy-surrounding-tamoxifen-treatment-and-thrombosis
#17
T N Augustine, K Pather, T Dix-Peek, R Duarte
BACKGROUND: Cancer is associated with hypercoagulability, with therapies including chemotherapy, radiation therapy, surgery and hormone-therapy linked to an increased risk of thrombotic complications. Notwithstanding the contribution of other haematological processes and components, platelets are implicated in contributing to a hypercoagulable state, with breast cancer patients receiving Tamoxifen treatment at a greater risk for thrombotic complications. METHOD: MCF-7 and T47D breast cancer cells were cultured under standard conditions, followed by treatment with 2uM Tamoxifen for 24 hours and co-cultured with whole blood (WB) for 2...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28872499/mean-platelet-volume-red-cell-distribution-width-and-neutrophil-to-lymphocyte-ratio-before-and-after-surgery-in-patients-with-carotid-body-tumors
#18
Nazim Bozan, Ömer Faruk Kocak, Mehmet Emre Dinc, Canser Yilmaz Demir, Mahfuz Turan, Ahmet Faruk Kiroglu
OBJECTIVE: Carotid body tumors (CBTs) are rare hypervascular benign tumors that originate from the paraganglia at the carotid bifurcation. The red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and mean platelet volume (MPV) may serve as markers in inflammatory, cardiovascular, and neoplastic diseases. However, their prognostic value in CBTs is unknown. The purpose of this study was to assess the leukocyte count, MPV, RDW, and NLR before and after surgery in patients with CBTs...
September 1, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28870391/determinants-of-adverse-outcomes-after-systemic-to-pulmonary-shunts-in-biventricular-circulation
#19
Ben Hobbes, Yves d'Udekem, Diana Zannino, Igor E Konstantinov, Christian Brizard, Johann Brink
BACKGROUND: Systemic-to-pulmonary shunts are useful palliative procedures, although many teams have been deterred by high mortality and morbidity. We aimed to identify predictors of adverse outcomes after shunts in biventricular lesions. METHODS: From 2004 to 2014, 173 children had shunt procedures. Morphologies included: tetralogy of Fallot, pulmonary atresia with ventricular septal defect (VSD) with and without major aortopulmonary collaterals (MAPCAs), transposition of great arteries with pulmonary stenosis, and double outlet right ventricle...
September 1, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28870057/-clinical-analysis-of-34-cases-with-sepsis-and-systemic-capillary-leak-syndrome
#20
H X Ma, X J Shi, Y R Liang, H D Shi, H Wang, Y S Zhao
Objective: To study the clinical characteristics of sepsis with systemic capillary leak syndrome(SCLS) and to evaluate the therapeutic effect and clinical significance of fluid therapy adjusted timely in these patients. Methods: The clinical data of 34 patients with sepsis and SCLS in the Department of Hepatobiliary Surgery ICU of General Hospital of People's Liberation Army General Hospital from July 2014 to January 2016 were retrospectively analyzed.There were 21 males and 13 females, aged from 21 to 74 years, with an average age of 56...
September 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
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