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myocardial sepsis

Rania Salah El-Zayat, Awny Gamal Shalaby
OBJECTIVES: Myocardial dysfunction is well recognized in severe sepsis and septic shock. Echocardiography provides rapid, noninvasive, and bedside evaluation of cardiac function in patients with hemodynamic instability. Mitral annular plane systolic excursion is an M-mode-derived echocardiographic variable used to assess longitudinal left ventricular systolic function. No data are available about the uses of mitral annular plane systolic excursion in children with septic shock. Therefore, we aimed to assess the prognostic significance of mitral annular plane systolic excursion in children with septic shock and to correlate it with the most commonly used measures of left ventricular systolic function and myocardial injury...
July 17, 2018: Pediatric Critical Care Medicine
Yu Fang, Jingfei Hu, Zhenhua Wang, Huili Zong, Lu Zhang, Ruifang Zhang, Limin Sun
OBJECTIVE: Sepsis is a whole-body inflammation disease after severe trauma, burn injury, infection and major surgeries, accompanied by multiple organs failure. We sought to investigate the potential mechanism of Aquaporin 1 (AQP1), miRNA-874, and lncRNA H19 in lipopolysaccharide (LPS) sepsis and the anti-inflammatory responses related to sepsis myocardial dysfunction. MATERIAL AND METHODS: Serum from peripheral blood samples of sepsis patients and in vivo mice model were collected for AQP1, H19, and miR-874 expression...
September 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jianjun Xu, Cai Lin, Tingting Wang, Peng Zhang, Zhengjun Liu, Caijiao Lu
BACKGROUND/AIMS: Ergosterol (ER) is the primary sterol found in fungi and is named after the ergot fungus. A variety of pharmacological activities have been reported for ER, including antioxidative, anti-proliferative, and anti-inflammatory effects, although its role in sepsis remains unclear. METHODS: The protective effect of ER on lipopolysaccharide (LPS)-induced sepsis myocardial injury was evaluated both in vivo and in vitro. Rats were pretreated with ER and then with LPS...
July 18, 2018: Cellular Physiology and Biochemistry
Karen E Joynt Maddox, E John Orav, Jie Zheng, Arnold M Epstein
BACKGROUND: The Center for Medicare and Medicaid Innovation (CMMI) launched the Bundled Payments for Care Improvement (BPCI) initiative in 2013. A subsequent study showed that the initiative was associated with reductions in Medicare payments for total joint replacement, but little is known about the effect of BPCI on medical conditions. METHODS: We used Medicare claims from 2013 through 2015 to identify admissions for the five most commonly selected medical conditions in BPCI: congestive heart failure (CHF), pneumonia, chronic obstructive pulmonary disease (COPD), sepsis, and acute myocardial infarction (AMI)...
July 19, 2018: New England Journal of Medicine
Anlei Liu, Juyuan Liu, Jun Xu, Huadong Zhu, Liang Zong, Xuezhong Yu
OBJECTIVE: To observe the role of dendritic cells (DC) in lipopolysaccharide (LPS)-induced myocardial dysfunction in mice. METHODS: Eighty wild type male C57BL/6 mice were divided into four groups, according to random number table method: sham group, DC inhibitors in control group (VAG539-sham group), LPS sepsis model group (LPS group) and DC inhibitors pretreatment group (VAG539-LPS group), 20 in each group. The cardiac dysfunction model of sepsis mice was established by LPS intraperitoneal injection; the sham group was injected with the same dose of normal saline...
June 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Matthew S Agam, Michelle A Wedemeyer, Bozena Wrobel, Martin H Weiss, John D Carmichael, Gabriel Zada
OBJECTIVE Pituitary adenomas (PAs) are benign neoplasms that are frequently encountered during workup for endocrinopathy, headache, or visual loss. Transsphenoidal surgery remains the first-line approach for PA resection. The authors retrospectively assessed complication rates associated with transsphenoidal PA resection from an institutional database. METHODS A retrospective analysis of 1153 consecutive transsphenoidal pituitary adenoma resections performed at the Keck Hospital of USC between November 1992 and March 2017 was conducted...
June 1, 2018: Journal of Neurosurgery
Robert H Blackwell, Anai N Kothari, Arpeet Shah, William Gang, Marcus L Quek, Fred A Luchette, Robert C Flanigan, Paul C Kuo, Gopal N Gupta
Objective: To describe the long-term incidence of adhesive bowel obstruction following major urologic surgery, and the effect of early surgery on perioperative outcomes. Methods: The Healthcare Cost and Utilization Project State Inpatient Databases for California and Florida (2006-2011) were used to identify major urologic oncologic surgery patients. Subsequent adhesive bowel obstruction admissions were identified and Kaplan-Meier time-to-event analysis was performed...
June 2018: Current Urology
Heini M Miettinen, Jeannie M Gripentrog, Connie I Lord, Jon O Nagy
Neutrophils are the most abundant white blood cells, with a vital role in innate immune defense against bacterial and fungal pathogens. Although mostly associated with pathological processes directly related to immune defense, they can also play a detrimental role in inflammatory conditions and have been found to have a pro-metastatic role in the spread of cancer cells. Here, we explore ways to temporarily suppress these detrimental activities. We first examined the possibility of using siRNA and antisense oligonucleotides (ASOs) for transient knockdown of the human and mouse C5a receptor, an important chemoattractant receptor involved in neutrophil-mediated injury that is associated with myocardial infarction, sepsis, and neurodegenerative diseases...
2018: PloS One
Robin Nance, Heidi Crane, Corey Ritchings, Lisa C Rosenblatt, Matthew Budoff, Susan R Heckbert, Daniel Drozd, William C Matthews, Elvin Geng, Peter W Hunt, Matthew J Feinstein, Richard Moore, Priscilla Hseu, Joseph J Eron, Greer A Burkholder, Benigno Rodriguez, Michael J Mugavero, Michael Saag, Mari M Kitahata, Joseph Ac Delaney
BACKGROUND: The Universal Myocardial infarction (MI) definition divides MIs into different types. Type 1 MIs (T1MI) result spontaneously from atherosclerotic plaque instability. Type 2 MIs (T2MI) are due to secondary causes of myocardial oxygen demand/supply mismatch such as occurs with sepsis. T2MI are much more common among those with HIV than in the general population. T1MI and T2MI have different mechanisms, risk factors and potential treatments suggesting that they should be distinguished to achieve a better scientific understanding of MIs in HIV...
July 7, 2018: AIDS Research and Human Retroviruses
Mohamed Morsy, Teresa Slomka, Anuj Shukla, Dipan Uppal, Ritin Bomb, Oluwaseun A Akinseye, Santhosh K G Koshy, Nadish Garg
BACKGROUND: Atrial fibrillation (AF) is a common arrhythmia after trauma or burn injury; however, its predisposing factors are not well known. Moreover, little is known about its effect on mortality and other short-term clinical outcomes. OBJECTIVES: This study is aimed at identifying risk factors for new-onset AF in patients admitted with blunt trauma or burn injuries at a Level 1 academic trauma center, and to determine its effects on the short-term clinical outcomes...
July 6, 2018: Echocardiography
Francisco Vasques-Nóvoa, Tiago L Laundos, Rui J Cerqueira, Catarina Quina-Rodrigues, Ricardo Soares-Dos-Reis, Fabiana Baganha, Sara Ribeiro, Luís Mendonça, Francisco Gonçalves, Carlos Reguenga, Wouter Verhesen, Fátima Carneiro, José Artur Paiva, Blanche Schroen, Paulo Castro-Chaves, Perpétua Pinto-do-Ó, Diana S Nascimento, Stephane Heymans, Adelino F Leite-Moreira, Roberto Roncon-Albuquerque
OBJECTIVES: Septic shock is a life-threatening clinical situation associated with acute myocardial and vascular dysfunction, whose pathophysiology is still poorly understood. Herein, we investigated microRNA-155-dependent mechanisms of myocardial and vascular dysfunction in septic shock. DESIGN: Prospective, randomized controlled experimental murine study and clinical cohort analysis. SETTING: University research laboratory and ICU at a tertiary-care center...
July 2, 2018: Critical Care Medicine
Jacek Hawiger
Sepsis is one of the ten leading causes of death in developed and developing countries. In the United States, sepsis mortality approaches that of acute myocardial infarction and exceeds deaths from stroke. Neonates and the elderly are the most vulnerable patients, with these groups suffering from the highest sepsis mortality. In both groups, many survivors respectively display serious developmental disabilities and cognitive decline. The National Institute of Health National Heart Lung and Blood Institute Panel redefined sepsis as a "severe endothelial dysfunction syndrome in response to intravascular and extravascular infections causing reversible or irreversible injury to the microcirculation responsible for multiple organ failure...
July 5, 2018: Kardiologia Polska
Wei-Ting Lin, Wan-Ling Chen, Chien-Ming Chao, Chih-Cheng Lai
This retrospective cohort study investigated the outcomes of patients with unplanned intensive care unit (ICU) readmission.All of the patients readmitted to ICU within 48 hours between 2010 and 2016 were enrolled.A total of 99 patients early readmitted to ICU were identified and their mean age of the patients was 68.8 ± 14.8 years. Respiratory failure was the most common cause of ICU readmission (n = 48, 48.5%), followed by acute myocardial ischemia or worsening heart failure (n = 25, 25.3%), sepsis (n = 22, 22...
June 2018: Medicine (Baltimore)
Xinhua Wang, Yuan Yu
Myocardial dysfunction is a major cause of death in sepsis. MicroRNA-146b (miR-146b) has been reported to be related to myocardial disease. However, the role of miR-146b in sepsis as well as myocardial injury is still unclear. Septic cardiac dysfunction in mice was induced by cecal ligation and puncture (CLP) and miR-146b was found increased significantly in the myocardium tissue of CLP mice. It was found that up-regulation of miR-146b by agomiR injection suppressed expression of IL-1β in mice as well as myocardium apoptosis in CLP mice...
June 27, 2018: Journal of Molecular Histology
Dagmar Jarkovska, Michaela Markova, Jan Horak, Lukas Nalos, Jan Benes, Mahmoud Al-Obeidallah, Zdenek Tuma, Jitka Sviglerova, Jitka Kuncova, Martin Matejovic, Milan Stengl
The complex pathogenesis of sepsis and septic shock involves myocardial depression, the pathophysiology of which, however, remains unclear. In this study, cellular mechanisms of myocardial depression were addressed in a clinically relevant, large animal (porcine) model of sepsis and septic shock. Sepsis was induced by fecal peritonitis in eight anesthetized, mechanically ventilated, and instrumented pigs of both sexes and continued for 24 h. In eight control pigs, an identical experiment but without sepsis induction was performed...
2018: Frontiers in Physiology
Sheryl Warttig, Phil Alderson, David Jw Evans, Sharon R Lewis, Irene S Kourbeti, Andrew F Smith
BACKGROUND: Sepsis is a life-threatening condition that is usually diagnosed when a patient has a suspected or documented infection, and meets two or more criteria for systemic inflammatory response syndrome (SIRS). The incidence of sepsis is higher among people admitted to critical care settings such as the intensive care unit (ICU) than among people in other settings. If left untreated sepsis can quickly worsen; severe sepsis has a mortality rate of 40% or higher, depending on definition...
June 25, 2018: Cochrane Database of Systematic Reviews
Mahek Shah, Brijesh Patel, Byomesh Tripathi, Manyoo Agarwal, Soumya Patnaik, Pradhum Ram, Shantanu Patil, Jooyoung Shin, Ulrich P Jorde
BACKGROUND: Cardiogenic shock (CS) in absence of acute myocardial infarction (AMI) has significant morbidity and mortality. This population of patients has been excluded from prior major randomized trials and observational studies. METHODS: We included patients with CS in absence of AMI from the 2013-14 HCUP's National Readmission Database. 30-day readmissions were studied and etiology for readmission was identified by using ICD-9CM codes in primary diagnosis field...
June 10, 2018: International Journal of Cardiology
Debbra Chong, Yan Ting Chua, Shu-Ling Chong, Gene Yong-Kwang Ong
Troponin I is a cardiac enzyme that is released during myocardial injury. However, cardiac enzymes are non-specific and can occur in many cardiac and non-cardiac pathologies. We aim to (1) describe the range of acute conditions that were associated with raised troponins in the paediatric population in our institution and (2) quantify the extent of troponin elevation and correlate it with the underlying aetiology. We performed a retrospective observational study in a tertiary institution which included patients from 1 January 2009 to 31 December 2013...
June 19, 2018: Pediatric Cardiology
Shigeyuki Yamashita, Tokiko Suzuki, Keisuke Iguchi, Takuya Sakamoto, Kengo Tomita, Hiroki Yokoo, Mari Sakai, Hiroki Misawa, Kohshi Hattori, Toshi Nagata, Yasuhide Watanabe, Naoyuki Matsuda, Naoki Yoshimura, Yuichi Hattori
Levosimendan and milrinone may be used in place of dobutamine to increase cardiac output in septic patients with a low cardiac output due to impaired cardiac function. The effects of the two inotropic agents on cardiac inflammation and left ventricular (LV) performance were examined in mice with cecal ligation and puncture (CLP)-induced sepsis. CLP mice displayed significant cardiac inflammation, as indicated by highly increased pro-inflammatory cytokines and neutrophil infiltration in myocardial tissues. When continuously given, levosimendan prevented but milrinone exaggerated cardiac inflammation, but they significantly reduced the elevations in plasma cardiac troponin-I and heart-type fatty acid-binding protein, clinical markers of cardiac injury...
June 20, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Hongmei Li, Yun Xing, Duomeng Yang, Xiangxu Tang, Daxiang Lu, Huadong Wang
It was demonstrated that α1 adrenergic receptor (α1-AR) activation by phenylephrine (PE) attenuated cardiac dysfunction in lipopolysaccharide (LPS) - challenged mice. However, it is unclear whether PE suppresses sepsis-induced cardiomyocyte apoptosis. Here, we investigated the effects of PE on cardiomyocyte apoptosis in LPS-treated adult rat ventricular myocytes (ARVMs) and septic rats induced by cecal ligation and puncture. Cardiomyocyte apoptosis and caspase activity were detected by TUNEL and spectrophotometrical assay, respectively...
June 8, 2018: Shock
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