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https://www.readbyqxmd.com/read/30442947/the-anticonvulsive-phenhydan-%C3%A2-suppresses-extrinsic-cell-death
#1
Caroline Moerke, Isabel Jaco, Christin Dewitz, Tammo Müller, Annette V Jacobsen, Jérémie Gautheron, Jürgen Fritsch, Jessica Schmitz, Jan Hinrich Bräsen, Claudia Günther, James M Murphy, Ulrich Kunzendorf, Pascal Meier, Stefan Krautwald
Different forms of regulated cell death-like apoptosis and necroptosis contribute to the pathophysiology of clinical conditions including ischemia-reperfusion injury, myocardial infarction, sepsis, and multiple sclerosis. In particular, the kinase activity of the receptor-interacting serine/threonine protein kinase 1 (RIPK1) is crucial for cell fate in inflammation and cell death. However, despite its involvement in pathological conditions, no pharmacologic inhibitor of RIPK1-mediated cell death is currently in clinical use...
November 15, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/30407069/cardiac-involvement-in-critically-ill-patients-with-leptospirosis-a-prospective-study-using-myocardial-deformation-imaging
#2
Anoop Mathew, Miriam Shanks, Eapen Punnoose, Louie Fischer, George Koshy, Rahul Potluri, Kevin R Bainey
BACKGROUND: Myocardial inflammation often complicates leptospirosis, a re-emerging global zoonosis. Leptospirosis associated myocardial dysfunction is equivocal and the pattern of cardiac involvement may not differ from that of sepsis associated myocarditis. METHODS: We prospectively compared cardiac involvement in 113 intensive care unit patients with severe leptospirosis to 31 patients with sepsis syndrome using a comprehensive assessment comprising of clinical presentation, electrocardiography, two-dimensional echocardiography (with global longitudinal strain calculation), and cardiac biomarker evaluation...
November 8, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/30402132/protective-effect-of-electroacupuncture-at-zusanli-on-myocardial-injury-in-septic-rats
#3
Lijian Zhang, Zhenjun Huang, Xian Shi, Sen Hu, Daniela Litscher, Lu Wang, Gerhard Litscher
The protective effect of electroacupuncture (EA) at Zusanli points (ST36) on myocardial injury in a model of sepsis was observed. Forty-eight male Sprague-Daley rats were subjected to sepsis by cecal ligation and puncture (CLP) and randomly divided into 4 groups (n=12; A: sepsis + EA; B: sepsis + sham acupuncture; C: sepsis + vagotomy; D: sepsis + vagotomy + EA). Bilateral points were stimulated (2mA, 2-100 Hz) for 1 hour. Abdominal vagotomy was performed in groups C and D. At 6h after CLP, the plasma activity of creatine kinase-MB (CK-MB) was determined...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30353940/early-enteral-nutrition-within-24-hours-of-lower-gastrointestinal-surgery-versus-later-commencement-for-length-of-hospital-stay-and-postoperative-complications
#4
REVIEW
Georgia Herbert, Rachel Perry, Henning Keinke Andersen, Charlotte Atkinson, Christopher Penfold, Stephen J Lewis, Andrew R Ness, Steven Thomas
BACKGROUND: This is an update of the review last published in 2011. It focuses on early postoperative enteral nutrition after lower gastrointestinal surgery. Traditional management consisted of 'nil by mouth', where patients receive fluids followed by solids after bowel function has returned. Although several trials have reported lower incidence of infectious complications and faster wound healing upon early feeding, other trials have shown no effect. The immediate advantage of energy intake (carbohydrates, protein or fat) could enhance recovery with fewer complications, and this warrants a systematic evaluation...
October 24, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30352239/remifentanil-attenuates-lipopolysaccharide-induced-oxidative-injury-by-downregulating-pkc%C3%AE-2-activation-and-inhibiting-autophagy-in-h9c2-cardiomyocytes
#5
Shaoqing Lei, Yuan Zhang, Wating Su, Lu Zhou, Jinjin Xu, Zhong-Yuan Xia
AIM: Lipopolysaccharide (LPS)-induced myocardial injury is a leading cause of death in patients with sepsis, which is associated with excessive activation of PKCβ (especially PKCβ2) and autophagy. Remifentanil, a μ-opioid receptor agonist, is well demonstrated to have beneficial effects during sepsis, but the underlying mechanisms are still unknown. The present study was designed to investigate the roles of remifentanil in PKCβ2 and autophagy in LPS-treated cardiomyocytes. MAIN METHODS: H9C2 cardiomyocytes were treated with or without remifentanil (2...
November 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/30342158/the-role-of-mitochondria-in-sepsis-induced-cardiomyopathy
#6
REVIEW
Giacomo Stanzani, Michael R Duchen, Mervyn Singer
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Myocardial dysfunction, often termed sepsis-induced cardiomyopathy, is a frequent complication and is associated with worse outcomes. Numerous mechanisms contribute to sepsis-induced cardiomyopathy and a growing body of evidence suggests that bioenergetic and metabolic derangements play a central role in its development; however, there are significant discrepancies in the literature, perhaps reflecting variability in the experimental models employed or in the host response to sepsis...
October 17, 2018: Biochimica et biophysica acta. Molecular basis of disease
https://www.readbyqxmd.com/read/30332561/opportunities-for-micrornas-in-the-crowded-field-of-cardiovascular-biomarkers
#7
Perry V Halushka, Andrew J Goodwin, Marc K Halushka
Cardiovascular diseases exist across all developed countries societies. Biomarkers that can predict or diagnose diseases early in their pathogeneses can reduce their morbidity and mortality in afflicted individuals. microRNAs are small regulatory RNAs that modulate translation and have been identified as potential fluid-based biomarkers across numerous maladies. We describe the current state of cardiovascular disease biomarkers across a range of diseases, including myocardial infarction, acute coronary syndrome, myocarditis, hypertension, heart failure, heart transplantation, aortic stenosis, diabetic cardiomyopathy, atrial fibrillation, and sepsis...
October 17, 2018: Annual Review of Pathology
https://www.readbyqxmd.com/read/30309409/-effect-of-left-ventricular-global-longitudinal-strain-on-prognosis-of-septic-septic-shock-patients-a-meta-analysis
#8
Jiahui Yuan, Min Chen, Shangzhong Chen, Caibao Hu, Guolong Cai, Jing Yan
OBJECTIVE: To systematically evaluate the effects of left ventricular global longitudinal strain (GLS) determined by two dimensional speckle tracking imaging technology (2D-STI) and left ventricular ejection fraction (LVEF) on the prognosis of patients with sepsis/septic shock. METHODS: Databases such as the National Library of Medicine PubMed database, Dutch medical abstracts Embase, Cochrane Library, Netherlands Elsevier, Springer and China biomedical literature database (CBMdisc), China National Knowledge Internet (CNKI), Wanfang database, China science and technology journal full-text database, Vip Chinese biomedical journal database were searched from the establishment of literature database to April 2018 to study GLS, LVEF and their relationships with mortality of septic/septic shock patients...
September 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/30300318/exploring-the-protective-role-and-the-mechanism-of-sphingosine-1-phosphate-in-endotoxic-cardiomyocytes
#9
Feng Kuai, Lei Wang, Jianhua Su, Yu Wang, Yi Han, Suming Zhou
FTY720 is a sphingosine 1 phosphate (S1P) receptor agonist approved for the treatment of multiple sclerosis (MS), which is a chronic inflammatory autoimmune disorder. Sepsis is a complex syndrome associated with progressive endotoxemic developments, which finally leads to damage of multiple organs, including the heart. In critical patients, cardiovascular dysfunction due to sepsis is a major cause of death. Previous studies have shown an association between S1P and cardioprotection in the situation of ischemia reperfusion and myocardial infarction...
October 8, 2018: Shock
https://www.readbyqxmd.com/read/30296324/timing-of-adverse-events-following-geriatric-hip-fracture-surgery-a-study-of-19-873-patients-in-the-american-college-of-surgeons-national-surgical-quality-improvement-program
#10
Daniel D Bohl, Andre M Samuel, Matthew L Webb, Adam M Lukasiewicz, Nathaniel T Ondeck, Bryce A Basques, Nidharshan S Anandasivam, Jonathan N Grauer
This study uses a prospective surgical registry to characterize the timing of 10 postoperative adverse events following geriatric hip fracture surgery. There were 19,873 patients identified who were ≥70 years undergoing surgery for hip fracture as part of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP). The median postoperative day of diagnosis (and interquartile range) for myocardial infarction was 3 (1-5), cardiac arrest requiring cardiopulmonary resuscitation 3 (0-8), stroke 3 (1-10), pneumonia 4 (2-10), pulmonary embolism 4 (2-11), urinary tract infection 7 (2-13), deep vein thrombosis 9 (4-16), sepsis 9 (4-18), mortality 11 (6-19), and surgical site infection 16 (11-22)...
September 2018: American Journal of Orthopedics
https://www.readbyqxmd.com/read/30279549/simvastatin-protects-cardiomyocytes-against-endotoxin-induced-apoptosis-and-up-regulates-survivin-nf-%C3%AE%C2%BAb-p65-expression
#11
Lana Nežić, Ranko Škrbić, Ljiljana Amidžić, Radoslav Gajanin, Kamil Kuča, Vesna Jaćević
This study is aimed to investigate whether simvastatin induces cardiomyocytes survival signaling in endotoxin (lipopolysaccharide, LSP)-induced myocardial injury, and if so, further to determine a role of survivin in simvastatin-anti-apoptotic effect. Wistar rats were pretreated with simvastatin (10-40 mg/kg po) before a single non-lethal dose of LPS. In myocardial tissue, LPS induced structural disorganization of myofibrils with significant inflammatory infiltrate (cardiac damage score, CDS = 3.87 ± 0...
October 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30278945/mortality-after-pancreaticoduodenectomy-assessing-early-and-late-causes-of-patient-death
#12
Sowmya Narayanan, Allison N Martin, Florence E Turrentine, Todd W Bauer, Reid B Adams, Victor M Zaydfudim
BACKGROUND: Safety of pancreaticoduodenectomy has improved significantly in the past 3 decades. Current inpatient and 30-d mortality rates are low. However, incidence and causes of 90-d and 1-y mortality are poorly defined and largely unexplored. METHODS: All patients who had pancreaticoduodenectomy between 2007 and 2016 were included in this single institution, retrospective cohort study. Distributions of pancreaticoduodenectomy-specific morbidity and cause-specific mortality were compared between early (within 90 d) and late (91-365 d) postoperative recovery periods...
November 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/30278924/outcomes-in-video-assisted-thoracoscopic-surgery-lobectomies-challenging-preconceived-notions
#13
D J Gross, E H Chang, P L Rosen, V Roudnitsky, M Muthusamy, G Sugiyama, P J Chung
BACKGROUND: Most thoracic surgical procedures in the United States are being performed by general surgeons (GSs) without any advanced training. With the recent approval of computed tomography screening for lung malignancy in high-risk populations, the number of thoracic oncologic resections is expected to rise. Previous literature has demonstrated consistently worsened outcomes for patients undergoing thoracic surgical procedure when done by nonthoracic fellowship-trained surgeons. Using the American College of Surgeons National Surgical Quality Improvement Project database, we examined short-term outcomes in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for malignancy...
November 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/30273666/sulfur-dioxide-attenuates-sepsis-induced-cardiac-dysfunction-via-inhibition-of-nlrp3-inflammasome-activation-in-rats
#14
Lin Yang, Hui Zhang, Peili Chen
OBJECTIVE: Sulfur dioxide (SO2 ) plays an important role in maintaining homeostasis of cardiovascular system. This study was aimed to investigate cardioprotective effects of SO2 on in the rat and the underlying mechanism. METHODS AND RESULTS: Sepsis model induced by cecal ligation and puncture (CLP) in rats were used. SO2 donor (NaHSO3 /Na2 SO3 , 1:3 M/M) was administered intraperitoneally at a dose of 85 mg/kg. Primary neonatal rat cardiac ventricular myocytes (NRCMs) were stimulated with LPS (1 mg/mL) in presence or absence of different concentrations of SO2 (10, 50 and 100 μmol/L)...
September 28, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/30271451/effect-of-xuefu-zhuyu-decoction-pretreatment-on-myocardium-in-sepsis-rats
#15
Fansu Meng, Haibiao Lai, Zekun Luo, Yong Liu, Xiaoxun Huang, Junqian Chen, Bayi Liu, Yingjun Guo, Yu Cai, Qingqing Huang
Xuefu Zhuyu Decoction (XFZYD), the classical recipe for promoting blood circulation by removing blood stasis, has been used in China for a long history clinically. XFZYD has been found to improve cardiac function through reducing inflammation. However, the effect of XFZYD on myocardial apoptosis remains unclear. Herein, we investigated the mechanism of XFZYD preconditioning on myocardial injury in sepsis rats. The rats were treated with XFZYD one week, followed with intraperitoneal injection of lipopolysaccharide (LPS: 10 mg/kg) to induce sepsis...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30260862/statistical-methods-dictate-the-estimated-impact-of-body-mass-index-on-major-and-minor-complications-after-total-joint-arthroplasty
#16
Mary J Kwasny, Adam I Edelstein, David W Manning
BACKGROUND: Elevated body mass index (BMI) is considered a risk factor for complications after THA and TKA. Stakeholders have proposed BMI cutoffs for those seeking arthroplasty. The research that might substantiate BMI cutoffs is sensitive to the statistical methods used, but the impact of the statistical methods used to model BMI has not been defined. QUESTIONS/PURPOSES: (1) How does the estimated postarthroplasty risk of minor and major complications vary as a function of the statistical method used to model BMI? (2) What is the prognostic value of BMI for predicting complications with each statistical method? METHODS: Using the American College of Surgeons National Surgical Quality Improvement Program from 2005 to 2012, we investigated the impact of BMI on major and minor complication risk for THA and TKA...
December 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/30258994/bacchus-a-randomised-non-comparative-phase-ii-study-of-neoadjuvant-chemotherapy-nact-in-patients-with-locally-advanced-rectal-cancer-larc
#17
R Glynne-Jones, M R Hall, A Lopes, S Pearce, V Goh, S Bosompem, J Bridgewater, I Chau, H Wasan, B Moran, L Melcher, N P West, P Quirke, W-L Wong, S Beare, N Hava, M Duggan, M Harrison
Background: Chemoradiation (CRT) or short-course radiotherapy (SCRT) are standard treatments for locally advanced rectal cancer (LARC). We evaluated the efficacy/safety of two neoadjuvant chemotherapy (NACT) regimens as an alternative prior to total mesorectal excision (TME). Methods/design: This multi-centre, phase II trial in patients with magnetic resonance imaging (MRI) defined high-risk LARC (>cT3b, cN2+ or extramural venous invasion) randomised patients (1:1) to FOLFOX + Bevacizumab (Arm 1) or FOLFOXIRI + bevacizumab (Arm 2) every 14 days for 6 cycles prior to surgery...
September 2018: Heliyon
https://www.readbyqxmd.com/read/30257883/inter-hospital-transfer-and-patient-outcomes-a-retrospective-cohort-study
#18
Stephanie Mueller, Jie Zheng, Endel John Orav, Jeffrey L Schnipper
BACKGROUND: Inter-hospital transfer (IHT, the transfer of patients between hospitals) occurs regularly and exposes patients to risks of discontinuity of care, though outcomes of transferred patients remains largely understudied. OBJECTIVE: To evaluate the association between IHT and healthcare utilisation and clinical outcomes. DESIGN: Retrospective cohort. SETTING: CMS 2013 100 % Master Beneficiary Summary and Inpatient claims files merged with 2013 American Hospital Association data...
September 26, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/30251139/evaluation-of-the-rate-of-marginal-ulcer-formation-after-bariatric-surgery-using-the-mbsaqip-database
#19
Benjamin Clapp, Joshua Hahn, Christopher Dodoo, Angela Guerra, Elizabeth de la Rosa, Alan Tyroch
BACKGROUND: Marginal ulcer (MU) formation is a known problem after gastric bypass. The Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database contains data from all US and Canadian Centers of Excellence including complication rates. We hypothesized that the short-term rate of ulceration is low. METHODS: We queried the MBSAQIP database for the year 2015. We searched patients with primary gastric bypass who developed MU. We then compared preoperative, operative, and postoperative characteristics with patients who did not develop MU...
September 24, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30247442/emergency-response-teams-in-and-outside-of-medicine-structurally-crafted-to-be-worlds-apart
#20
Joseph Fernandez-Moure, Jose L Pascual, Niels R Martin, Holly Rodgers, Lewis J Kaplan
Medical Emergency Response Teams (MERTs) are widespread throughout inpatient hospital care facilities. Besides the rise of the ubiquitous rapid response team, current MERTs span trauma, stroke, myocardial infarction, and sepsis in many hospitals. Given the multiplicity of teams with widely varying membership, leadership, and functionality, the structure of MERTs is appropriate to review to determine opportunities for improvement. Since non-medical ERTs predate MERT genesis, and are similar across multiple disciplines, non-medical ERTs provides a standard against which to compare and review MERT design and function...
September 21, 2018: Journal of Trauma and Acute Care Surgery
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