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https://www.readbyqxmd.com/read/29149094/genomic-analysis-of-third-generation-cephalosporin-resistant-escherichia-coli-from-dairy-cow-manure
#1
Muhammad Attiq Rehman, Xianhua Yin, Dion Lepp, Chad Laing, Kim Ziebell, Guylaine Talbot, Edward Topp, Moussa Sory Diarra
The production of extended-spectrum β-lactamases (ESBLs) conferring resistance to new derivatives of β-lactams is a major public health threat if present in pathogenic Gram-negative bacteria. The objective of this study was to characterize ceftiofur (TIO)- or cefotaxime (FOX)-resistant Escherichia coli isolated from dairy cow manure. Twenty-four manure samples were collected from four farms and incubated under anaerobic conditions for 20 weeks at 4 °C or at 25 °C. A total of 37 TIO- or FOX-resistant E. coli were isolated from two of the four farms to determine their susceptibility to 14 antibiotics...
November 17, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29148877/characterization-and-horizontal-transfer-of-antimicrobial-resistance-genes-and-integrons-in-bacteria-isolated-from-cooked-meat-products-in-china
#2
Tao Yu, Xiaobing Jiang, Yu Liang, Yanping Zhu, Jinhe Tian, Hao Ying, Xuannian Wang, Lei Shi
The aim of this study was to investigate antimicrobial resistance and the presence and transferability of corresponding resistance genes and integrons in bacteria isolated from cooked meat samples in the People's Republic of China. A total of 150 isolates (22 species belonging to 15 genera) were isolated from 49 samples. Resistance of these isolates to antimicrobials was commonly observed; 42.7, 36.0, and 25.3% of the isolates were resistant to tetracycline, streptomycin, and ampicillin, respectively. Multidrug resistance was observed in 41 (27...
November 17, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29140102/comparative-genomics-of-type-1-incc-plasmids-from-china
#3
Lizhi Ma, Zhe Yin, Defu Zhang, Zhe Zhan, Qian Wang, Xiongbo Duan, Huixia Gao, Quanhui Liang, Yuzong Zhao, Jiao Feng, Yachao Zhao, Yigang Tong, Erhei Dai, Dongsheng Zhou
AIM: This study dealt with genomic characterization of type 1 IncC resistance plasmids, capable of spreading across taxonomic borders, from China. MATERIALS & METHODS: p112298-tetA was sequenced and compared with type 1 IncC reference plasmid pR148 and two available sequenced type 1 IncC plasmids pHS36-NDM and pVAS3-1 from China. RESULTS: These plasmids contained one or more exogenous resistance islands, which included the ARI-A islands, the ARI-B islands, the ISEcp1-blaCMY units and the bla KPC-2 region and were inserted at various sites in the IncC backbone and thus represented three distinct lineages...
November 15, 2017: Future Microbiology
https://www.readbyqxmd.com/read/29139076/extended%C3%A2-spectrum%C3%A2-beta-lactamase-esbl-producing-bacteria-isolated-from-hospital-wastewaters-rivers-and-aquaculture-sources-in-nigeria
#4
Olawale Olufemi Adelowo, Serena Caucci, Omowunmi Abosede Banjo, Ozioma Chinyere Nnanna, Eunice Olubunmi Awotipe, Florence Bosede Peters, Obasola Ezekiel Fagade, Thomas U Berendonk
Untreated wastewater is a risk factor for the spread of antibiotic resistance in the environment. However, little is known about the contribution of untreated wastewater to the burden of antibiotic resistance in the Nigerian environment. In this study, a total of 143 ceftazidime-/cefpodoxime-resistant bacteria isolated from untreated wastewater and untreated wastewater-contaminated surface and groundwater in Nigeria were screened for extended-spectrum β-lactamase (ESBL) genes, integrons and integron gene cassettes by PCR...
November 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29136108/perturbation-of-gabaergic-synapses-at-the-axon-initial-segment-of-basolateral-amygdala-induces-trans-regional-metaplasticity-at-the-medial-prefrontal-cortex
#5
Rinki Saha, Kuldeep Shrivastava, Liang Jing, Rachel Schayek, Mouna Maroun, Martin Kriebel, Hansjürgen Volkmer, Gal Richter-Levin
GABAergic synapses in the basolateral amygdala (BLA) play an important role in fear memory generation. We have previously reported that reduction in GABAergic synapses innervating specifically at the axon initial segment (AIS) of principal neurons of BLA, by neurofascin (NF) knockdown, impairs fear extinction. BLA is bidirectionally connected with the medial prefrontal cortex (mPFC), which is a key region involved in extinction of acquired fear memory. Here, we showed that reducing AIS GABAergic synapses within the BLA leads to impairment of synaptic plasticity in the BLA-mPFC pathway, as well as in the ventral subiculum (vSub)-mPFC pathway, which is independent of BLA involvement...
November 9, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29135933/adolescent-alcohol-drinking-renders-adult-drinking-bla-dependent-bla-hyper-activity-as-contributor-to-comorbid-alcohol-use-disorder-and-anxiety-disorders
#6
Mahsa Moaddab, Elizabeth Mangone, Madelyn H Ray, Michael A McDannald
Adolescent alcohol drinking increases the risk for alcohol-use disorder in adulthood. Yet, the changes in adult neural function resulting from adolescent alcohol drinking remain poorly understood. We hypothesized that adolescent alcohol drinking alters basolateral amygdala (BLA) function, making alcohol drinking BLA-dependent in adulthood. Male, Long Evans rats were given voluntary, intermittent access to alcohol (20% ethanol) or a bitter, isocaloric control solution, across adolescence. Half of the rats in each group received neurotoxic BLA lesions...
November 14, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29126393/genomic-characterisation-of-clinical-and-environmental-pseudomonas-putida-group-strains-and-determination-of-their-role-in-the-transfer-of-antimicrobial-resistance-genes-to-pseudomonas-aeruginosa
#7
Silke Peter, Philipp Oberhettinger, Leonard Schuele, Ariane Dinkelacker, Wichard Vogel, Daniela Dörfel, Daniela Bezdan, Stephan Ossowski, Matthias Marschal, Jan Liese, Matthias Willmann
BACKGROUND: Pseudomonas putida is a Gram-negative, non-fermenting bacterium frequently encountered in various environmental niches. P. putida rarely causes disease in humans, though serious infections and outbreaks have been reported from time to time. Some have suggested that P. putida functions as an exchange platform for antibiotic resistance genes (ARG), and thus represents a serious concern in the spread of ARGs to more pathogenic organisms within a hospital. Though poorly understood, the frequency of ARG exchange between P...
November 10, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29126320/screening-lactic-acid-bacteria-to-manufacture-two-stage-fermented-feed-and-pelleting-to-investigate-the-feeding-effect-on-broilers
#8
Ruei Han Yeh, Chia Wen Hsieh, Kuo Lung Chen
Bacillus subtilis var. natto N21 (BS) and different lactic acid bacteria were applied to produce two-stage fermented feeds. Broilers were fed these feeds to select the best fermented feed. The selected fermented feed was pelleted and investigated for its effects on growth performance, carcass traits, intestinal microflora, serum biochemical constituents, and apparent ileal nutrient digestibility. Trial 1 involved three hundred thirty-six 1-d-old broilers with equal numbers of each sex, randomly assigned into control, BS + Bacillus coagulans L12 (BBC), BS + Lactobacillus casei (BLC), BS + Lactobacillus acidophilus (BLA), BS + Lactobacillus acidophilus L15 (BLA15), BS + Lactobacillus delbruekckii (BLD), and BS + Lactobacillus reuteri P24 (BLR24) groups with 3 replicates per group...
November 4, 2017: Poultry Science
https://www.readbyqxmd.com/read/29120560/klebsiella-pneumoniae-oxa-48-in-a-urology-patient-case-report
#9
Ines Jajić, Ana Benčić, Marko Siroglavić, Gernot Zarfel, Boris Ružić, Ivan Pezelj, Branka Bedenić
We present an isolate of Klebsiella pneumoniae OXA-48 isolated in a 68-year-old man who underwent radical prostatectomy due to prostate cancer. The antibiotic susceptibility testing to a wide range of antibiotics was performed by disk diffusion method and determination of minimal inhibitory concentrations. The isolate was classified as multidrug-resistant. It showed intermediate susceptibility to imipenem and meropenem, resistance to ertapenem, and sensitivity only to colistin, amikacin, and trimethoprim-sulfamethoxazole...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29117549/prefrontal-cortex-drives-distinct-projection-neurons-in-the-basolateral-amygdala
#10
Laura M McGarry, Adam G Carter
The prefrontal cortex (PFC) regulates emotional behavior via top-down control of the basolateral amygdala (BLA). However, the influence of PFC inputs on the different projection pathways within the BLA remains largely unexplored. Here, we combine whole-cell recordings and optogenetics to study these cell-type specific connections in mouse BLA. We characterize PFC inputs onto three distinct populations of BLA neurons that project to the PFC, ventral hippocampus, or nucleus accumbens. We find that PFC-evoked synaptic responses are strongest at amygdala-cortical and amygdala-hippocampal neurons and much weaker at amygdala-striatal neurons...
November 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/29116187/a-translational-study-on-looming-evoked-defensive-response-and-the-underlying-subcortical-pathway-in-autism
#11
Yu Hu, Zhuoming Chen, Lu Huang, Yue Xi, Bingxiao Li, Hong Wang, Jiajian Yan, Tatia M C Lee, Qian Tao, Kwok-Fai So, Chaoran Ren
Rapidly approaching objects indicating threats can induce defensive response through activating a subcortical pathway comprising superior colliculus (SC), lateral posterior nucleus (LP), and basolateral amygdala (BLA). Abnormal defensive response has been reported in autism, and impaired synaptic connections could be the underlying mechanism. Whether the SC-LP-BLA pathway processes looming stimuli abnormally in autism is not clear. Here, we found that looming-evoked defensive response is impaired in a subgroup of the valproic acid (VPA) mouse model of autism...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114204/acute-ethanol-administration-upregulates-synaptic-%C3%AE-4-subunit-of-neuronal-nicotinic-acetylcholine-receptors-within-the-nucleus-accumbens-and-amygdala
#12
Josephine R Tarren, Henry A Lester, Arnauld Belmer, Selena E Bartlett
Alcohol and nicotine are two of the most frequently abused drugs, with their comorbidity well described. Previous data show that chronic exposure to nicotine upregulates high-affinity nicotinic acetylcholine receptors (nAChRs) in several brain areas. Effects of ethanol on specific brain nAChR subtypes within the mesolimbic dopaminergic (DA) pathway may be a key element in the comorbidity of ethanol and nicotine. However, it is unknown how alcohol affects the abundance of these receptor proteins. In the present study, we measured the effect of acute binge ethanol on nAChR α4 subunit levels in the prefrontal cortex (PFC), nucleus accumbens (NAc), ventral tegmental area (VTA), and amygdala (Amg) by western blot analysis using a knock-in mouse line, generated with a normally functioning α4 nAChR subunit tagged with yellow fluorescent protein (YFP)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29108985/serotonergic-neurons-mediate-the-anxiolytic-effect-of-l-dopa-neuronal-correlates-in-the-amygdala
#13
Emilie Faggiani, Frederic Naudet, Marcus L F Janssen, Yasin Temel, Abdelhamid Benazzouz
Anxiety in Parkinson's disease is a comorbid non-motor symptom that alters the quality of life of patients. Its neuronal substrates and those of l-Dopa treatment are still poorly known. Using different combinations of monoaminergic system lesions in the rat, we addressed the contribution of these systems in the efficacy of l-DOPA on anxiety and on the neuronal activity of basolateral amygdala (BLA), a brain structure involved in anxiety. Anxiety, locomotor activity and motor performance were assessed using the elevated plus maze, the open field and the skinner box, respectively...
November 3, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29107199/kindling-epileptogenesis-and-panic-like-behavior-their-bidirectional-connection-and-contribution-to-epilepsy-associated-depression
#14
Jesús-Servando Medel-Matus, Don Shin, Raman Sankar, Andrey Mazarati
Anxiety is one of the most common comorbidities of epilepsy, which has major detrimental effects on the quality of life. Generalized anxiety disorder (GAD) associated with epilepsy has been receiving most attention. However, several other forms of anxiety reportedly present in patients with epilepsy, including panic disorder (PD). In this study, using an animal model of limbic epilepsy, we examined the interplay between epilepsy and panic-like behavior (PLB). Further, considering the high degree of comorbidity between depression on the one hand, and both epilepsy and PD on the other hand, we studied whether and how the presence of PLB in animals with epilepsy would affect their performance in depression-relevant tests...
October 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29100991/cue-induced-reinstatement-of-alcohol-seeking-behavior-is-associated-with-increased-camkii-t286-phosphorylation-in-the-reward-pathway-of-mice
#15
Michael C Salling, Christopher J Hodge, Kelly E Psilos, Vallari R Eastman, Sara P Faccidomo, Clyde W Hodge
Cue-induced reinstatement of alcohol-seeking is a hallmark behavioral pathology of addiction. Evidence suggests that reinstatement (e.g., relapse), may be regulated by cell signaling systems that underlie neuroplasticity. A variety of plasticity events require activation of calcium calmodulin-dependent protein kinase II (CaMKII) in components of the reward pathway, such as the nucleus accumbens and amygdala. We sought to determine if cue-induced reinstatement of alcohol-seeking behavior is associated with changes in the activation state (e...
October 31, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29091469/case-study-dose-response-of-caffeine-on-20-km-handcycling-time-trial-performance-in-a-para-triathlete
#16
Terri Graham-Paulson, Claudio Perret, Victoria Goosey-Tolfrey
Caffeine's ability to influence upper-body exercise (UBE) endurance performance may be related to an individual's training status. This case study therefore aimed to investigate the ergogenic effects of caffeine dose on 20 km time trial (TT) performance of an elite male Para-triathlete (wheelchair user) (age 46 y, body mass 76.9 kg, body fat 25.4%, handcycling V̇O2peak 3.45 l·min(-1)). The athlete completed four 20 km handcycling TT's on a Cyclus II ergometer under laboratory controlled conditions following the ingestion of 2, 4 and 6 mg·kg(-1) caffeine (CAF) or placebo (PLA)...
November 1, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29083128/acute-neuromuscular-cognitive-and-physiological-responses-to-a-japanese-kickboxing-competition-in-semi-professional-fighters
#17
Giuseppe Cimadoro
BACKGROUND: Japanese kickboxing is a combat sport designed to accommodate fighters from different combat sports styles. However, the physiological profile of this discipline is unknown. Therefore, this study describes the neuromuscular, metabolic and cognitive responses to an official Japanese kickboxing (K-1) fight in 8 kickboxers. METHODS: Measurements before and after the competition involved a simple reaction time test (SRT), countermovement jump (CMJ), blood lactate (BLA) and rating of perceived exertion (RPE)...
October 27, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29080676/amygdaloid-involvement-in-the-defensive-behavior-of-mice-exposed-to-the-open-elevated-plus-maze
#18
Tatiani Sorregotti, Ana Cláudia Cipriano, Fábio Cardoso Cruz, Diego Cardozo Mascarenhas, Robert John Rodgers, Ricardo Luiz Nunes-de-Souza
Previous studies have shown that the exposure to an open elevated plus maze (oEPM, an EPM with all four open arms) elicits fear/anxiety-related responses in laboratory rodents. However, very little is known about the underlying neural substrates of these defensive behaviors. Accordingly, the present study investigated the effects of chemical inactivation of the amygdala [through local injection of cobalt chloride (CoCl2: a nonspecific synaptic blocker)] on the behavior of oEPM-exposed mice. In a second experiment, the pattern of activation of the basolateral (BLA) and central (CeA) nuclei of the amygdala was assessed through quantification of Fos protein expression in mice subjected to one of several behavioral manipulations...
October 31, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29080675/activation-of-crf-crfr1-signaling-in-the-basolateral-nucleus-of-the-amygdala-contributes-to-chronic-forced-swim-induced-depressive-like-behaviors-in-rats
#19
Lin Chen, Song Li, Jie Cai, Tian-Jiao Wei, Ling-Yu Liu, Hong-Yan Zhao, Bo-Heng Liu, Hong-Bo Jing, Zi-Run Jin, Min Liu, You Wan, Guo-Gang Xing
The basolateral nucleus of the amygdala (BLA) plays a key role in processing stressful events and affective disorders. Previously we have documented that exposure of chronic forced swim (FS) to rats produces a depressive-like behavior and that sensitization of BLA neurons is involved in this process. In the present study, we demonstrated that chronic FS stress (CFSS) could activate corticotrophin-releasing factor (CRF)/CRF receptor type 1 (CRFR1) signaling in the BLA, and blockade of CRF/CRFR1 signaling by intra-BLA injection of NBI27914 (NBI), a selective CRFR1 antagonist, could prevent the CFSS-induced depressive-like behaviors in rats, indicating that activation of CRF/CRFR1 signaling in the BLA is required for CFSS-induced depression...
October 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29079689/basolateral-amygdala-neurons-maintain-aversive-emotional-salience
#20
Auntora Sengupta, Joanna O Y Yau, Philip Jean-Richard Dit Bressel, Yu Liu, Zayra E Millan, John M Power, Gavan P McNally
Basolateral amygdala (BLA) neurons serve a well-accepted role in fear conditioning and fear extinction. However, the specific learning processes related to their activity at different times during learning remain poorly understood. We addressed this using behavioral tasks isolating distinct aspects of fear learning in male rats. We show that brief optogenetic inhibition of BLA neurons around moments of aversive reinforcement or non-reinforcement causes reductions in the salience of conditioned stimuli, rendering these stimuli less able to be learned about and less able to control fear or safety behaviours...
October 27, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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