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JOURNAL ARTICLE
Yu Lu, Aoxi Cui, Xiaobo Zhang
Colorectal cancer (CRC), a malignant tumor worldwide, is associated with gut microbiota. The influence of gut microbe-derived metabolites on CRC has attracted a lot of attention. However, the role of immunity mediated by commensal microbiota-derived metabolites in tumorigenesis of CRC is not intensively explored. Here we monitored the gut microbial dysbiosis in CRC mouse model ( Apc Min/+ model) without dietary and pharmacological intervention, followed by characterized of metabolites enriched in CRC model mice...
2024: Gut Microbes
#22
JOURNAL ARTICLE
Furong Yan, Linlin Zhang, Lian Duan, Liyang Li, Xuanqi Liu, Yifei Liu, Tiankui Qiao, Yiming Zeng, Hao Fang, Duojiao Wu, Xiangdong Wang
Metabolic abnormalities represent one of the pathological features of chronic obstructive pulmonary disease (COPD). Glutamic pyruvate transaminase 2 (GPT2) is involved in glutamate metabolism and lipid synthesis pathways, whilst the exact roles of GPT2 in the occurrence and development of COPD remains uncertain. This study aims at investigating how GPT2 and the associated genes modulate smoking-induced airway epithelial metabolism and damage by reprogramming lipid synthesis. The circulating or human airway epithelial metabolomic and lipidomic profiles of COPD patients or cell-lines explored with smoking were assessed to elucidate the pivotal roles of GPT2 in reprogramming processes...
May 2024: Clinical and Translational Medicine
#23
JOURNAL ARTICLE
Jiangling Guo, Peipei Han, Yaqing Zheng, Yahui Wu, Kai Zheng, Chuanjun Huang, Yue Wang, Cheng Chen, Yiqiong Qi, Xiaoyu Chen, Qiongying Tao, Jiayi Zhai, Qi Guo
Depression is a serious psychiatric illness that causes great inconvenience to the lives of elderly individuals. However, the diagnosis of depression is somewhat subjective. Nontargeted gas chromatography (GC)/liquid chromatography (LC)-mass spectrometry (MS) was used to study the plasma metabolic profile and identify objective markers for depression and metabolic pathway variation. We recruited 379 Chinese community-dwelling individuals aged ≥ 65. Plasma samples were collected and detected by GC/LC‒MS...
May 5, 2024: Scientific Reports
#24
REVIEW
Anna Maya Powell, Fouzia Zahid Ali Khan, Jacques Ravel, Michal A Elovitz
This review illuminates the complex interplay between various maternal microbiomes and their influence on preterm birth (PTB), a driving and persistent contributor to neonatal morbidity and mortality. Here, we examine the dynamics of oral, gastrointestinal (gut), placental, and vaginal microbiomes, dissecting their roles in the pathogenesis of PTB. Importantly, focusing on the vaginal microbiome and PTB, the review highlights (1) a protective role of Lactobacillus species; (2) an increased risk with select anaerobes; and (3) the influence of social health determinants on the composition of vaginal microbial communities...
June 2024: Clinics in Perinatology
#25
REVIEW
Victoria C Ward, Steven Hawken, Pranesh Chakraborty, Gary L Darmstadt, Kumanan Wilson
Preterm birth (PTB) is a leading cause of morbidity and mortality in children aged under 5 years globally, especially in low-resource settings. It remains a challenge in many low-income and middle-income countries to accurately measure the true burden of PTB due to limited availability of accurate measures of gestational age (GA), first trimester ultrasound dating being the gold standard. Metabolomics biomarkers are a promising area of research that could provide tools for both early identification of high-risk pregnancies and for the estimation of GA and preterm status of newborns postnatally...
June 2024: Clinics in Perinatology
#26
REVIEW
David K Stevenson, Virginia D Winn, Gary M Shaw, Sarah K England, Ronald J Wong
Solving the puzzle of preterm birth has been challenging and will require novel integrative solutions as preterm birth likely arises from many etiologies. It has been demonstrated that many sociodemographic and psychological determinants of preterm birth relate to its complex biology. It is this understanding that has enabled the development of a novel preventative strategy, which integrates the omics profile (genome, epigenome, transcriptome, proteome, metabolome, microbiome) with sociodemographic, environmental, and psychological determinants of individual pregnant people to solve the puzzle of preterm birth...
June 2024: Clinics in Perinatology
#27
JOURNAL ARTICLE
Zhe Li, Yun Zheng, Hua Ma, Fuyi Cui
Microcystins release from bloom-forming cyanobacteria is considered a way to gain competitive advantage in Microcystis populations, which threaten water resources security and aquatic ecological balance. However, the effects of microcystins on microalgae are still largely unclear. Through simulated culture experiments and the use of UHPLC-MS-based metabolomics, the effects of two microcystin-LR (MC-LR) concentrations (400 and 1,600 μg/L) on the growth and antioxidant properties of three algae species, the toxic Microcystis aeruginosa, a non-toxic Microcystis sp...
April 2024: Harmful Algae
#28
JOURNAL ARTICLE
Xin Lv, Yangzhi Liu, Shujing Liu, Yuhan Liu, Yang Qu, Qian Cai
ETHNOPHARMACOLOGICAL RELEVANCE: Gentiana radix (GR) and wine-processed Gentiana radix (WGR) are commonly used in folk medicine for the treatment of bile or liver disorders, including jaundice, hepatitis, swelling or inflammation for thousands of years. However, the therapeutic effects of gentian root (GR) and wine-made gentian root (WGR) treatment on damp-heat jaundice syndrome (DHJS) have not been studied in animal experiments. AIM OF THE STUDY: This study aimed to investigate the protective effects and mechanisms of GR and WGR on DHJS in rats...
May 3, 2024: Journal of Ethnopharmacology
#29
JOURNAL ARTICLE
Xiaohong Wang, Jiawei Zhou, Tianlin Jiang, Jun Xu
Depression, a prevalent and multifaceted mental disorder, has emerged as a significant public health concern due to its escalating prevalence and heightened risk of severe suicidality. Given its profound impact, the imperative for preventing and intervening in depression is paramount. Substantial evidence underscores intricate connections between depression and cardiovascular health. SheXiangXinTongNing (XTN), a recognized traditional Chinese medicine for treating Coronary Heart Disease (CHD), prompted our exploration into its antidepressant effects and underlying mechanisms...
April 20, 2024: Phytomedicine
#30
JOURNAL ARTICLE
Yuexia Lin, Lingwei Sun, Yuhua Lv, Rongrong Liao, Keqing Zhang, Jinyong Zhou, Shushan Zhang, Jiehuan Xu, Mengqian He, Caifeng Wu, Defu Zhang, Xiaohui Shen, Jianjun Dai, Jun Gao
BACKGROUND: The transcriptome and metabolome dissection of the skeletal muscle of high- and low- growing individuals from a crossbred population of the indigenous Chongming white goat and the Boer goat were performed to discover the potential functional differentially expressed genes (DEGs) and differential expression metabolites (DEMs). RESULTS: A total of 2812 DEGs were detected in 6 groups at three time stages (3,6,12 Month) in skeletal muscle using the RNA-seq method...
May 4, 2024: BMC Genomics
#31
JOURNAL ARTICLE
Jie Jun Wong, Jien Sze Ho, Louis L Y Teo, Hai Ning Wee, Kee Voon Chua, Jianhong Ching, Fei Gao, Swee Yaw Tan, Ru-San Tan, Jean-Paul Kovalik, Angela S Koh
BACKGROUND: We previously reported changes in the serum metabolome associated with impaired myocardial relaxation in an asymptomatic older community cohort. In this prospective parallel-group randomized control pilot trial, we subjected community adults without cardiovascular disease to exercise intervention and evaluated the effects on serum metabolomics. METHODS: Between February 2019 to November 2019, thirty (83% females) middle-aged adults (53 ± 4 years) were randomized with sex stratification to either twelve weeks of moderate-intensity exercise training (Intervention) (n = 15) or Control (n = 15)...
May 4, 2024: Commun Med (Lond)
#32
JOURNAL ARTICLE
Tzipi Braun, Rui Feng, Amnon Amir, Nina Levhar, Hila Shacham, Ren Mao, Rotem Hadar, Itamar Toren, Yadid Algavi, Kathleen Abu-Saad, Shuoyu Zhuo, Gilat Efroni, Alona Malik, Orit Picard, Miri Yavzori, Bella Agranovich, Ta-Chiang Liu, Thaddeus S Stappenbeck, Lee Denson, Ofra Kalter-Leibovici, Eyal Gottlieb, Elhanan Borenstein, Eran Elinav, Minhu Chen, Shomron Ben-Horin, Yael Haberman
Crohn disease (CD) burden has increased with globalization/urbanization, and the rapid rise is attributed to environmental changes rather than genetic drift. The Study Of Urban and Rural CD Evolution (SOURCE, n = 380) has considered diet-omics domains simultaneously to detect complex interactions and identify potential beneficial and pathogenic factors linked with rural-urban transition and CD. We characterize exposures, diet, ileal transcriptomics, metabolomics, and microbiome in newly diagnosed CD patients and controls in rural and urban China and Israel...
May 4, 2024: Nature Communications
#33
JOURNAL ARTICLE
Katri Vaparanta, Johannes A M Merilahti, Veera K Ojala, Klaus Elenius
New tools for cell signaling pathway inference from multi-omics data that are independent of previous knowledge are needed. Here we propose a new de novo method, the de novo multi-omics pathway analysis (DMPA), to model and combine omics data into network modules and pathways. DMPA was validated with published omics data and was found accurate in discovering reported molecular associations in transcriptome, interactome, phosphoproteome, methylome, and metabolomics data and signaling pathways in multi-omics data...
May 2, 2024: Molecular & Cellular Proteomics: MCP
#34
REVIEW
Paula A Hernandez, John Churchill Bradford, Priyanka Brahmachary, Sophia Ulman, Jennifer L Robinson, Ronald K June, Magali Cucchiarini
OBJECTIVE: Sufficient evidence within the past two decades have shown that osteoarthritis (OA) has a sex-specific component. However, efforts to reveal the biological causes of this disparity have emerged more gradually. In this narrative review, we discuss anatomical differences within the knee, incidence of injuries in youth sports, and metabolic factors that present early in life (childhood and early adulthood) that can contribute to a higher risk of OA in females. DESIGN: We compiled clinical data from multiple tissues within the knee joint -since OA is a whole joint disorder- aiming to reveal relevant factors behind the sex differences from different perspectives...
May 2, 2024: Osteoarthritis and Cartilage
#35
JOURNAL ARTICLE
Ginny Xiaohe Li, Lijun Chen, Yi Hsiao, Rahul Mannan, Yuping Zhang, Jie Luo, Francesca Petralia, Hanbyul Cho, Noshad Hosseini, Felipe da Veiga Leprevost, Anna Calinawan, Yize Li, Shankara Anand, Aniket Dagar, Yifat Geffen, Chandan Kumar-Sinha, Seema Chugh, Anne Le, Sean Ponce, Shenghao Guo, Cissy Zhang, Michael Schnaubelt, Nataly Naser Al Deen, Feng Chen, Wagma Caravan, Andrew Houston, Alex Hopkins, Chelsea J Newton, Xiaoming Wang, Daniel A Polasky, Sarah Haynes, Fengchao Yu, Xiaojun Jing, Siqi Chen, Ana I Robles, Mehdi Mesri, Mathangi Thiagarajan, Eunkyung An, Gad A Getz, W Marston Linehan, Galen Hostetter, Scott D Jewell, Daniel W Chan, Pei Wang, Gilbert S Omenn, Rohit Mehra, Christopher J Ricketts, Li Ding, Arul M Chinnaiyan, Marcin P Cieslik, Saravana M Dhanasekaran, Hui Zhang, Alexey I Nesvizhskii
Non-clear cell renal cell carcinomas (non-ccRCCs) encompass diverse malignant and benign tumors. Refinement of differential diagnosis biomarkers, markers for early prognosis of aggressive disease, and therapeutic targets to complement immunotherapy are current clinical needs. Multi-omics analyses of 48 non-ccRCCs compared with 103 ccRCCs reveal proteogenomic, phosphorylation, glycosylation, and metabolic aberrations in RCC subtypes. RCCs with high genome instability display overexpression of IGF2BP3 and PYCR1...
April 26, 2024: Cell reports medicine
#36
JOURNAL ARTICLE
Venkatesh L Murthy, Jonathan D Mosley, Andrew S Perry, David R Jacobs, Kahraman Tanriverdi, Shilin Zhao, Konrad T Sawicki, Mercedes Carnethon, John T Wilkins, Matthew Nayor, Saumya Das, E Dale Abel, Jane E Freedman, Clary B Clish, Ravi V Shah
While weight gain is associated with a host of chronic illnesses, efforts in obesity have relied on single "snapshots" of body mass index (BMI) to guide genetic and molecular discovery. Here, we study >2,000 young adults with metabolomics and proteomics to identify a metabolic liability to weight gain in early adulthood. Using longitudinal regression and penalized regression, we identify a metabolic signature for weight liability, associated with a 2.6% (2.0%-3.2%, p = 7.5 × 10-19 ) gain in BMI over ≈20 years per SD higher score, after comprehensive adjustment...
April 25, 2024: Cell reports medicine
#37
JOURNAL ARTICLE
Shanshan Xu, Hao Zhou, Boyang Xu, Wuyang Liu, Weiqi Hu, Qinxiang Xu, Jiong Hong, Yongxin Liu, Xingjiang Li
Environmental-origin microbiota significantly influences Red Heart Qu (RH_Qu) stratification, but their microbial migration and metabolic mechanisms remain unclear. Using high-throughput sequencing and metabolomics, we divided the stratification of RH_Qu into three temperature-based stages. Phase I features rising temperatures, causing microbial proliferation and a two-layer division. Phase II, characterized by peak temperatures, sees the establishment of thermotolerant species like Bacillus, Thermoactinomyces, Rhodococcus, and Thermoascus, forming four distinct layers and markedly altering metabolite profiles...
April 16, 2024: Food Chemistry
#38
JOURNAL ARTICLE
Manal E Alosaimi, Badriyah S Alotaibi, Maram H Abduljabbar, Reem M Alnemari, Atiah H Almalki, Ahmed Serag
This research investigates the effects of the immunotherapeutic agent nivolumab on the metabolism of lung cancer cells (NCI-H1975) using GC-MS metabolomic profiling. Multivariate analysis such as unsupervised PCA and supervised OPLS-DA along with univariate analysis and pathway analysis were employed to explore the metabolomic data and identify altered metabolic pathways induced by nivolumab treatment. The study revealed distinct metabolic alterations in cancer cells, linked to proliferative and survival advantages, such as enhanced glycolysis, increased glutaminolysis, and modified amino acid metabolism...
April 30, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
#39
JOURNAL ARTICLE
Ao Li, Yuancheng Wang, Xia Li, Jiahui Yin, Yadong Li, Yaofang Hu, Junzhu Zou, Junxiang Liu, Zhenyuan Sun
Phosphorus (P) plays a crucial role in facilitating plant adaptation to cadmium (Cd) stress. However, the molecular mechanisms underlying P-mediated responses to Cd stress in roots remain elusive. This study investigates the effects of P on the growth, physiology, transcriptome, and metabolome of Salix caprea under Cd stress. The results indicate that Cd significantly inhibits plant growth, while sufficient P alleviates this inhibition. Under Cd exposure, P sufficiency resulted in increased Cd accumulation in roots, along with reduced oxidative stress levels (superoxide anion and hydrogen peroxide contents were reduced by 16...
April 30, 2024: Plant Physiology and Biochemistry: PPB
#40
JOURNAL ARTICLE
Abdul Rehman, Fuyi Huang, Zixing Zhang, Théogène Habumugisha, Changzhou Yan, Uzma Shaheen, Xian Zhang
Nanoplastics (NPs) are increasingly pervasive in the environment, raising concerns about their potential health implications, particularly within aquatic ecosystems. This study investigated the impact of polystyrene nanoparticles (PSN) on zebrafish liver metabolism using liquid chromatography hybrid quadrupole time of flight mass spectrometry (LC-QTOF-MS) based non-targeted metabolomics. Zebrafish were exposed to 50 nm PSN for 28 days at low (L-PSN) and high (H-PSN) concentrations (0.1 and 10 mg/L, respectively) via water...
May 1, 2024: Environment International
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