keyword
MENU ▼
Read by QxMD icon Read
search

Alpha melanocyte stimulating hormone

keyword
https://www.readbyqxmd.com/read/27924732/the-effect-of-a-hexanoic-acid-linker-insertion-on-the-pharmacokinetics-and-tumor-targeting-properties-of-the-melanoma-imaging-agent-99mtc-hynic-cycmsh
#1
Vania Teixeira, Marcelo Fernández, Natalia Oddone, Xiuli Zhang, Fabio Gallazzi, Hugo Cerecetto, Juan Pablo Gambini, Williams Porcal, Pablo Cabral, Thomas P Quinn
BACKGROUND: Lactam cyclized alpha-melanocyte stimulating hormone (α-MSH) analogues exhibit high stability and affinity for the MC1-R receptors over expressed in melanoma cells. Recently, we reported a novel <sup>99m</sup>Tc-HYNIC-cycMSH<sub>4-13</sub> analogue with the HYNIC chelator directly attached to the lactam cyclized ring. OBJECTIVE: In this study we proposed the introduction of a 6-aminohexanoic acid (Ahx) linker between the HYNIC chelator and lactam cyclized peptide cycMSH4-13 to reduce steric hindrance and improve the melanoma targeting and imaging proprieties of the radiolabeled peptide...
December 6, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27917799/effect-of-one-unit-blood-donation-on-appetite-related-biomarkers
#2
Husamettin Erdamar, Muzaffer Cakmak
PURPOSE: It is commonly reported that blood donation (BD) leads to an increase in appetite. To investigate this claim, a questionnaire was offered to 306 people who had a history of BD at least once in their life. Following a positive outcome from the questionnaire, we further investigated the impact of BD on appetite. MATERIALS AND METHODS: The questionnaire study consists of a 5-question survey with VAS was performed on 399 volunteers. Later, 108 volunteers were enrolled in a laboratory study...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27819350/%C3%AE-msh-and-foxc2-promote-fatty-acid-oxidation-through-c-ebp%C3%AE-negative-transcription-in-mice-adipose-tissue
#3
Lu Gan, Zhenjiang Liu, Yizhe Chen, Dan Luo, Fei Feng, Guannv Liu, Chao Sun
Alpha melanocyte stimulating hormone (α-MSH) and Forkhead box C2 protein (Foxc2) enhance lipolysis in multiple tissues. However, their relationship in adipose fatty acid oxidation (FAO) remains unclear. Here, we demonstrated that α-MSH and Foxc2 increased palmitate oxidation to CO2 in white (WAT) and brown adipose tissue (BAT). C/EBPβ expression was reduced by α-MSH and Foxc2. FFA level was elevated by α-MSH and pc-Foxc2 treatment along with increased FAO in white and brown adipocytes. The expression of FAO key enzymes, medium-chain acyl-CoA dehydrogenase (MCAD) and long-chain acyl-CoA dehydrogenase (LCAD) were increased in α-MSH and pc-Foxc2 group...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27754127/os-25-02-origin-of-neurogenic-hypertension-and-the-sympatho-excitation-in-diet-induced-obesity
#4
Joon Kyungjoon Lim, Benjie Barzel, Sandra Burke
OBJECTIVE: Hypertension affects one third of the population around the world and is a major contributor to cardiovascular disease. There is strong evidence that the main cause of hypertension is increases sympathetic nerve activity to specific organs. Plasma leptin levels correlate with blood pressure (BP) and renal sympathetic nerve activity (RSNA). The central effects of leptin are mediated primarily through the arcuate (ARC) nucleus of the hypothalamus. Both neuropeptide-Y (NPY) and alpha-melanocyte stimulating hormone (α-MSH) containing neurons ascend from the ARC and terminate in ventromedial hypothalamus (VMH) which are the key centres of energy homeostasis, hemodynamics and sympathetic tone to renal vasculature...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27717825/%C3%AE-msh-promotes-preadipocyte-proliferation-by-alleviating-er-stress-induced-leptin-resistance-and-by-activating-notch1-signal-in-mice
#5
Lu Gan, Zhenjiang Liu, Tianjiao Wu, Fei Feng, Chao Sun
Alpha-melanocyte stimulating hormone (αMSH) has an important role in the regulation of body weight and energy expenditure. Nevertheless, the molecular mechanisms of circulating αMSH on preadipocyte proliferation remain elusive. We found αMSH was reduced by high fat diet (HFD) while leptin was elevated in adipose tissue. Leptin resistance and endoplasmic reticulum (ER) stress of adipose tissue were increased in obese mice. αMSH increased leptin sensitivity and alleviated ER stress along with increased p-STAT3 level and reduced SOCS3, GRP78, CHOP, ATF4, p27 and p53 levels...
October 5, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27643054/os-25-02-origin-of-neurogenic-hypertension-and-the-sympatho-excitation-in-diet-induced-obesity
#6
Joon Kyungjoon Lim, Benjie Barzel, Sandra Burke
OBJECTIVE: Hypertension affects one third of the population around the world and is a major contributor to cardiovascular disease. There is strong evidence that the main cause of hypertension is increases sympathetic nerve activity to specific organs. Plasma leptin levels correlate with blood pressure (BP) and renal sympathetic nerve activity (RSNA). The central effects of leptin are mediated primarily through the arcuate (ARC) nucleus of the hypothalamus. Both neuropeptide-Y (NPY) and alpha-melanocyte stimulating hormone (α-MSH) containing neurons ascend from the ARC and terminate in ventromedial hypothalamus (VMH) which are the key centres of energy homeostasis, hemodynamics and sympathetic tone to renal vasculature...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27614713/effects-of-alpha-melanocyte-stimulating-hormone-on-mitochondrial-energy-metabolism-in-rats-of-different-age-groups
#7
René G Feichtinger, Erika Pétervári, Michaela Zopf, Silvia Vidali, Sepideh Aminzadeh-Gohari, Johannes A Mayr, Barbara Kofler, Márta Balaskó
Hypothalamic alpha-melanocyte-stimulating hormone (α-MSH) is a key catabolic mediator of energy homeostasis. Its anorexigenic and hypermetabolic effects show characteristic age-related alterations that may be part of the mechanism of middle-aged obesity and geriatric anorexia/cachexia seen in humans and other mammals. We aimed to investigate the role of α-MSH in mitochondrial energy metabolism during the course of aging in a rodent model. To determine the role of α-MSH in mitochondrial energy metabolism in muscle, we administered intracerebroventricular (ICV) infusions of α-MSH for 7-days to different age-groups of male Wistar rats...
August 26, 2016: Neuropeptides
https://www.readbyqxmd.com/read/27508820/-op-7b-01-neurogenic-hypertension-and-the-sympatho-excitation-in-diet-induced-obesity
#8
K Lim, B Barzel, S Burke, G Head
OBJECTIVE: Obesity is closely associated with a greater risk of developing hypertension and strong link exist between bodyweight gain and greater blood pressure (BP). Plasma leptin levels correlate with BP and renal sympathetic nerve activity (RSNA). The central effects of leptin are mediated primarily through the arcuate (ARC) nucleus of the hypothalamus. Dense projections of both Neuropeptide Y (NPY) and alpha-melanocyte stimulating hormone (α-MSH) containing neurons ascend from the ARC and terminate in several hypothalamic nuclei such as the ventromedial hypothalamus (VMH) which are the key centres of energy homeostasis, hemodynamics and sympathetic tone to brown adipose and renal vasculature...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27402666/stimulation-of-the-hypothalamic-arcuate-nucleus-increases-brown-adipose-tissue-nerve-activity-via-hypothalamic-paraventricular-and-dorsomedial-nuclei
#9
Vineet C Chitravanshi, Kazumi Kawabe, Hreday N Sapru
Hypothalamic arcuate nucleus (ARCN) stimulation elicited increases in sympathetic nerve activity (IBATSNA) and temperature (TBAT) of interscapular brown adipose tissue (IBAT). The role of hypothalamic dorsomedial (DMN) and paraventricular (PVN) nuclei in mediating these responses was studied in urethane-anesthetized, artificially ventilated, male Wistar rats. In different groups of rats, inhibition of neurons in the DMN and PVN by microinjections of muscimol attenuated the increases in IBATSNA and TBAT elicited by microinjections of N-methyl-d-aspartic acid into the ipsilateral ARCN...
August 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27376341/the-tripeptide-kdpt-ameliorates-ongoing-psoriasis-like-skin-inflammation-in-murine-and-human-skin
#10
Nadine Sucker, Lars Klenner, Christoph Baumann, Matteo Auriemma, Carlo Sternemann, Michael Soeberdt, Graham R Elliott, Christoph Abels, Thomas A Luger, Karin Loser
Psoriasis is a chronic inflammatory disease appearing as scaly erythematous cutaneous lesions, which are characterized by parakeratosis and acanthosis as well as the infiltration of immune cells, like T helper-1 and T helper-17 cells. Here, we demonstrated that KdPT, a tripeptide structurally related to the C-terminal amino acids of alpha-melanocyte-stimulating hormone, which was previously shown to exhibit anti-inflammatory effects in intestinal inflammation, ameliorated ongoing disease in the mouse model of imiquimod-induced psoriasis-like skin inflammation and in the small xenotransplant mouse model of psoriasis...
July 4, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27339773/regulatory-alterations-of-energy-homeostasis-in-spontaneously-hypertensive-rats-shr
#11
Nora Furedi, Alexandra Miko, Bianka Aubrecht, Balazs Gaszner, Diana Feller, Ildiko Rostas, Judit Tenk, Szilvia Soos, Marta Balasko, Andras Balogh, Marianna Pap, Erika Petervari
Spontaneously hypertensive rats (SHR) have high sympathetic tone and progressive hypertension. Chronic calorie-restriction prevents hypertension. Their food intake (FI) and body weight are lower than in normotensive (NT) controls, even on a high-fat diet, suggesting a dysregulation of energy homeostasis. We assumed enhanced activity of hypothalamic anorexigenic melanocortins and diminished tone of orexigenic neuropeptide Y (NPY) in the background. FI of male SHR and NT Wistar rats was recorded in a FeedScale system upon intracerebroventricular injection of NPY, melanocortin ligands alpha-melanocyte-stimulating hormone (alpha-MSH), and agouti-related peptide (AgRP) or during a 7-day intracerebroventricular infusion of melanocortin antagonist HS024...
August 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27303631/ultraviolet-b-melanin-and-mitochondrial-dna-%C3%A2-photo-damage-in-human-epidermal-keratinocytes-and-melanocytes%C3%A2-modulated-by-alpha-melanocyte-stimulating-hormone
#12
Markus Böhm, Helene Z Hill
Alpha-melanocyte-stimulating hormone (alpha-MSH) increases melanogenesis and protects from UV-induced DNA damage. However, its effect on mitochondrial DNA (mtDNA) damage is unknown. We have addressed this issue in a pilot study using human epidermal keratinocytes and melanocytes incubated with alpha-MSH and irradiated with UVB. Real-time touchdown PCR was used to quantify total and deleted mtDNA. The deletion detected encompassed the common deletion but was more sensitive to detection. There were 4.4 times more mtDNA copies in keratinocytes than in melanocytes...
2016: F1000Research
https://www.readbyqxmd.com/read/27242663/comparative-effect-of-acth-and-related-peptides-on-proliferation-and-growth-of-rat-adrenal-gland
#13
REVIEW
Claudimara Ferini Pacicco Lotfi, Pedro O R de Mendonca
Pro-opiomelanocortin (POMC) is a polypeptide precursor known to yield biologically active peptides related to a range of functions. These active peptides include the adrenocorticotropic hormone (ACTH), which is essential for maintenance of adrenal growth and steroidogenesis, and the alpha-melanocyte stimulation hormone, which plays a key role in energy homeostasis. However, the role of the highly conserved N-terminal region of POMC peptide fragments has begun to be unraveled only recently. Here, we review the cascade of events involved in regulation of proliferation and growth of murine adrenal cortex triggered by ACTH and other POMC-derived peptides...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27220989/anticancer-activity-of-7-8-dihydroxyflavone-in-melanoma-cells-via-downregulation-of-%C3%AE-msh-camp-mitf-pathway
#14
Deok Yong Sim, Jae Kyung Sohng, Hye Jin Jung
Malignant melanoma is one of the most aggressive skin cancer and highly resistant to most conventional treatment. In the present study, we aimed to investigate the anticancer effects and mechanisms of action of 7,8-dihydroxyflavone (7,8-DHF), a monophenolic flavone, in melanoma cells. At concentrations not exhibiting cytotoxicity, 7,8-DHF potently inhibited growth and clonogenic survival of alpha-melanocyte stimulating hormone (α-MSH)-stimulated B16F10 melanoma cells. Furthermore, it significantly blocked migration and invasion of the metastatic melanoma cells...
July 2016: Oncology Reports
https://www.readbyqxmd.com/read/27160450/factors-affecting-puberty-in-replacement-beef-heifers
#15
REVIEW
G A Perry
Puberty is defined as when ovulation is accompanied by visual signs of estrus and subsequent normal luteal function. Age at puberty is an important trait in relation to reproductive success, productive life span, and profitability in beef operations. Although puberty and initiation of normal estrous cycles are complex events that require maturation of the hypothalamic-pituitary-ovarian axis, it has been well documented that nutrition, age, and genetics are regulators of age at puberty. However, their role is mainly as regulators of the endocrine maturation that must occur for sustained ovarian cyclicity to be initiated...
July 1, 2016: Theriogenology
https://www.readbyqxmd.com/read/27154870/changes-in-the-female-arcuate-nucleus-morphology-and-neurochemistry-after-chronic-ethanol-consumption-and-long-term-withdrawal
#16
Elce C C Rebouças, Sandra Leal, Susana M Silva, Susana I Sá
Ethanol is a macronutrient whose intake is a form of ingestive behavior, sharing physiological mechanisms with food intake. Chronic ethanol consumption is detrimental to the brain, inducing gender-dependent neuronal damage. The hypothalamic arcuate nucleus (ARN) is a modulator of food intake that expresses feeding-regulatory neuropeptides, such as alpha melanocyte-stimulating hormone (α-MSH) and neuropeptide Y (NPY). Despite its involvement in pathways associated with eating disorders and ethanol abuse, the impact of ethanol consumption and withdrawal in the ARN structure and neurochemistry in females is unknown...
May 3, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27149948/regulation-of-feeding-behavior-and-food-intake-by-appetite-regulating-peptides-in-wild-type-and-growth-hormone-transgenic-coho-salmon
#17
Samantha L White, Helene Volkoff, Robert H Devlin
Survival, competition, growth and reproductive success in fishes are highly dependent on food intake, food availability and feeding behavior and are all influenced by a complex set of metabolic and neuroendocrine mechanisms. Overexpression of growth hormone (GH) in transgenic fish can result in greatly enhanced growth rates, feed conversion, feeding motivation and food intake. The objectives of this study were to compare seasonal feeding behavior of non-transgenic wild-type (NT) and GH-transgenic (T) coho salmon (Oncorhynchus kisutch), and to examine the effects of intraperitoneal injections of the appetite-regulating peptides cholecystokinin (CCK-8), bombesin (BBS), glucagon-like peptide-1 (GLP-1), and alpha-melanocyte-stimulating hormone (α-MSH) on feeding behavior...
August 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27067506/targeted-radionuclide-therapy-of-melanoma
#18
REVIEW
Abdullah Norain, Ekaterina Dadachova
An estimated 60,000 individuals in the United States and 132,000 worldwide are yearly diagnosed with melanoma. Until recently, treatment options for patients with stages III-IV metastatic disease were limited and offered marginal, if any, improvement in overall survival. The situation changed with the introduction of B-RAF inhibitors and anti-cytotoxic T-lymphocyte antigen 4 and anti-programmed cell death protein 1 immunotherapies into the clinical practice. With only some patients responding well to the immune therapies and with very serious side effects and high costs of immunotherapy, there is still room for other approaches for the treatment of metastatic melanoma...
May 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27066320/the-melanocortin-receptor-type-3-agonist-d-trp-8-%C3%AE-msh-decreases-inflammation-and-muscle-wasting-in-arthritic-rats
#19
Ana Belen Gómez-SanMiguel, Ana Isabel Martín, María Paz Nieto-Bona, Carmen Fernández-Galaz, María Ángeles Villanúa, Asunción López-Calderón
BACKGROUND: Chronic inflammatory diseases induce cachexia that increases mortality and morbidity of the illness. Adjuvant-induced arthritis is an experimental model of rheumatoid arthritis that is associated with body weight loss and muscle wasting. Alpha-melanocyte stimulating hormone has an anti-inflammatory effect in arthritic rats and decreases muscle wasting. The aim of this work was to elucidate whether the anti-cachectic action of alpha-melanocyte stimulating hormone is mediated by the melanocortin receptor type 3 pathway...
March 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/26939131/beneficial-effect-of-covalently-grafted-%C3%AE-msh-on-endothelial-release-of-inflammatory-mediators-for-applications-in-implantable-devices
#20
Guillaume Le Saux, Laurent Plawinski, Sylvain Nlate, Jean Ripoche, Thierry Buffeteau, Marie-Christine Durrieu
Intravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical challenge. Herein we report on the production and the characterization of gold surfaces covalently derivatized with the peptide α-alpha-melanocyte stimulating hormone (α-MSH), with a quantifiable surface density. In vitro study demonstrated that the tethered α-MSH is able to decrease the expression of an inflammatory cytokine produced by endothelial cells...
2016: PloS One
keyword
keyword
108371
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"