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https://www.readbyqxmd.com/read/27905819/mothers-preferences-regarding-new-combination-vaccines-for-their-children-in-japan-2014
#1
Aiko Shono, Masahide Kondo
A number of new vaccines to prevent childhood diseases have been introduced globally over the last few decades. Only four combination vaccines are currently available in Japan, DTaP/sIPV, DTaP, DT, and MR, leading to complex infant vaccine scheduling. This study aims to investigate mothers' preferences with respect to combination vaccines for their children, should new combination vaccines become available that have not yet been launched in Japan or that will be developed in the future. We conducted a web-based, cross-sectional survey of 1,243 mothers who had at least one child between 2 months and 3 years of age...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27891698/vaccination-and-unexplained-sudden-death-risk-in-taiwanese-infants
#2
Wan-Ting Huang, Robert T Chen, Yu-Chen Hsu, John W Glasser, Philip H Rhodes
PURPOSE: In March 1992, eight infants who had died within 36 hours of receiving whole-cell pertussis vaccine (diphtheria, tetanus, and whole-cell pertussis [DTwP]) prompted the Taiwan health authorities to suspend its use. We conducted an investigation of vaccination and sudden unexplained infant death (SUID) and repeated it more recently after Taiwan switched to acellular pertussis vaccine (diphtheria, tetanus, and acellular pertussis [DTaP]) in 2010. METHODS: All SUIDs aged 31-364 days during 1990-1992 and 1996-2013 were selected from the death registration databases...
November 28, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27889711/immunogenicity-and-safety-of-a-liquid-hexavalent-vaccine-in-indian-infants
#3
Jugesh Chhatwal, Sanjay Lalwani, Emmanuel Vidor
OBJECTIVE: To evaluate the immunogenicity and safety of a fully liquid, hexavalent diphtheria tetanus acellular pertussis inactivated poliovirus hepatitis B Haemophilus influenzae type b (DTaP IPV HB PRPT) vaccine in Indian infants. DESIGN: Phase III, single-arm study. SETTING: Two tertiary care hospitals. PARTICIPANTS: 177 healthy, 6-week-old infants. INTERVENTION: All participants received HB and OPV vaccines at birth and DTaP-IPV-HB-PRP~T at 6, 10, 14 weeks of age...
November 5, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27862309/study-of-greek-children-and-youths-with-cystic-fibrosis-identifies-immunisation-gaps-and-delays
#4
Helena C Maltezou, Stavros Doudounakis, Maria Lekaditi, Kalliopi Tanou, Panos Katerelos, Maria Theodoridou
AIM: Data about immunisation rates in cystic fibrosis (CF) patients are scarce. We estimated the rates and timeliness of immunisations in CF patients aged 0.55-22 years. METHODS: We studied 122 subjects at a hospital in Greece in 2014. A standard questionnaire was used to collect data and parents' opinions about immunisations. RESULTS: The complete immunisation rates were 92.6% for diphtheria-tetanus-acellular pertussis-inactivated poliomyelitis-Haemophilus influenzae (DTaP-IPV-Hib), 96...
November 10, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27858500/undervaccination-with-diphtheria-tetanus-and-pertussis-vaccine-national-trends-and-association-with-pertussis-risk-in-young-children
#5
Wan-Ting Huang, Hui-Chen Lin, Chin-Hui Yang
BACKGROUND: The high coverage for ≥3 pertussis vaccine doses among Taiwanese children might not imply timely vaccination. Recently, resurgence of pertussis and challenges with availability of DTaP-IPV-Hib prompted this study. METHODS: In the 1996-2012 national birth cohort, we calculated the prevalence and days of undervaccination against pertussis by age 36 months. We also compared the odds of undervaccination in each laboratory-confirmed pertussis patient at ages 3-35 months with sex-, residence-, and age-matched controls from the general population, using conditional logistic regression...
November 18, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27855142/errata-vol-65-no-39
#6
(no author information available yet)
For the report, "Vaccination Coverage Among Children in Kindergarten - United States, 2015-16 School Year," on page 1061, the third sentence of the second full paragraph should read, "For example, the California Department of Public Health worked to improve vaccination coverage at schools identified from local-level data as having high levels of provisional enrollment." In addition, the fifth sentence of the same paragraph should read, "As a result, from 2014-15 to 2015-16, the number of provisionally enrolled kindergartners decreased from 36,731 (6...
November 18, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27846055/a-phase-iii-randomized-double-blind-clinical-trial-of-an-investigational-hexavalent-vaccine-given-at-2-3-4-and-12-months
#7
Timo Vesikari, Thomas Becker, Andre F Vertruyen, Katleen Poschet, Sheryl A Flores, Marco F Pagnoni, Jin Xu, G Frank Liu, Jon E Stek, Florence Boisnard, Stéphane Thomas, Eddy Ziani, Andrew W Lee
BACKGROUND: Combination vaccines simplify vaccination visits and improve coverage and timeliness. DTaP5-HB-IPV-Hib is a new investigational, fully-liquid, combination vaccine containing a 5-antigen pertussis component and which is designed to protect against 6 infectious diseases. METHODS: In this multicenter, double-blind, comparator-controlled, Phase III study (NCT01341639) conducted in Finland, Germany, and Belgium, healthy infants were randomized 1:1 to receive one of two immunization regimens...
November 11, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27810316/uptake-of-rotavirus-vaccine-among-us-infants-at-immunization-information-system-sentinel-sites
#8
Kimberly Pringle, Cristina V Cardemil, Laura J Pabst, Umesh D Parashar, Margaret M Cortese
OBJECTIVE: Coverage with rotavirus vaccine among US children has been lower compared to that with other routine childhood vaccines. Our objectives were to examine rotavirus vaccine (RV) uptake over time compared to other routine vaccinations, ages at administration, and quantitate potential missed opportunities for RV receipt. METHODS: We analyzed data from 6 Immunization Information System (IIS) Sentinel Sites, which represent approximately 10% of the United States (US) pediatric population...
December 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27753797/a-randomized-controlled-study-of-dtap-ipv-hb-prp-t-a-fully-liquid-hexavalent-vaccine-administered-in-a-3-5-and-11-12-month-schedule
#9
Timo Vesikari, Sven Arne Silfverdal, Emilia Jordanov, Emmanuel Feroldi
OBJECTIVE: To assess the immunogenicity and safety of a fully liquid, ready-to-use hexavalent DTaP-IPV-HB-PRP-T vaccine when administered in a 2+1 schedule at 3, 5, 11-12 months of age. METHODS: Phase III, randomized, active-controlled, observer-blind, multi-center study. Infants were randomized to receive DTaP-IPV-HB-PRP-T (N=275) or a licensed control hexavalent vaccine (DTaP-IPV-HB//PRP~T: N=275), both given in co-administration with Prevenar 13™ (PCV13). Serum was analyzed for immune responses to all vaccine antigens...
October 6, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27741577/rotavirus-vaccination-rate-disparities-seen-among-infants-with-acute-gastroenteritis-in-georgia
#10
Trisha C Parker, Anaam Mohammed, Traci Leong, Shelley Mays, Shabnam Jain, Victoria Churchill, Fatima Ali, Lilly C Immergluck
OBJECTIVE: Rotavirus (RV) is one of the most common diarrheal diseases affecting children less than 5 years of age. RV vaccines have greatly reduced this burden in the United States. The purpose of this study was to determine possible disparities and socio-economic differences in RV vaccination rates. DESIGN: Children with acute gastroenteritis were enrolled. Stool was tested for presence of rotavirus using an enzyme immunoassay kit. Vaccination records were abstracted from the state immunization registry and healthcare providers to examine complete and incomplete vaccination status...
October 14, 2016: Ethnicity & Health
https://www.readbyqxmd.com/read/27727029/kaiser-permanente-northern-california-pregnancy-database-description-and-proof-of-concept-study
#11
Ousseny Zerbo, Berwick Chan, Kristin Goddard, Ned Lewis, Karin Bok, Nicola P Klein, Roger Baxter
BACKGROUND/OBJECTIVE: We describe the establishment of a dynamic database linking mothers to newborns with the goal of studying vaccine safety in both pregnant women and their children and provide results of a study utilizing this database as a proof of concept. METHODS: All Kaiser Permanente Northern California (KPNC) live births and their mothers were eligible for inclusion in the pregnancy database. We used the medical record number (MRN), a unique identifier, to retrieve information about events that occurred during the pregnancy and at delivery and linked this same MRN to newborns for post-partum follow up...
October 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27711037/vaccination-coverage-among-children-in-kindergarten-united-states-2015-16-school-year
#12
Ranee Seither, Kayla Calhoun, Jenelle Mellerson, Cynthia L Knighton, Erica Street, Vance Dietz, J Michael Underwood
State-mandated vaccination requirements for school entry protect children and communities against vaccine-preventable diseases (1). Each school year, federally funded immunization programs (e.g., states, territories, jurisdictions) collect and report kindergarten vaccination data to CDC. This report describes vaccination coverage estimates in all 50 states and the District of Columbia (DC), and the estimated number of kindergartners with at least one vaccine exemption in 47 states and DC, during the 2015-16 school year...
October 7, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27711036/vaccination-coverage-among-children-aged-19-35-months-united-states-2015
#13
Holly A Hill, Laurie D Elam-Evans, David Yankey, James A Singleton, Vance Dietz
Sustained high coverage with recommended vaccinations among children has kept many vaccine-preventable diseases at low levels in the United States (1). To assess coverage with vaccinations recommended for children by age 2 years in the United States (2), CDC analyzed data collected by the 2015 National Immunization Survey (NIS) for children aged 19-35 months (born January 2012-May 2014). Overall, coverage did not change during 2014-2015. Coverage in 2015 was highest for ≥3 doses of poliovirus vaccine (93...
October 7, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27648948/effect-of-topically-applied-anaesthetic-formulation-on-the-sensitivity-of-scoop-dehorning-wounds-in-calves
#14
Dominique McCarthy, Peter Andrew Windsor, Charissa Harris, Sabrina Lomax, Peter John White
The post-operative effects of three formulations of topical anaesthetic and a cornual nerve block on the sensitivity of scoop dehorning wounds in calves were compared in two trials. In Trial 1, 21 female Holstein dairy calves aged 8 to 24 weeks were randomly allocated to two groups: (1) scoop dehorning with a post-operative application of a novel topical anaesthetic powder (DTAP, n = 10); and (2) scoop dehorning with a post-operative application of a novel topical anaesthetic ethanol liquid (DTAE, n = 11). In Trial 2, 18 castrated male and 18 female Hereford beef calves aged 16 to 20 weeks were randomly allocated to four groups: (1) scoop dehorning with a pre-operative cornual nerve block of lignocaine (DCB, n = 9); (2) scoop dehorning with a post-operative application of the novel topical anaesthetic ethanol liquid from Trial 1 (DTAE, n = 9); (3) scoop dehorning with a post-operative application of a topical anaesthetic gel (DTAG, n = 9); and (4) sham dehorning (CON, n = 9)...
2016: PloS One
https://www.readbyqxmd.com/read/27624956/effectiveness-of-prenatal-tetanus-diphtheria-and-acellular-pertussis-vaccination-on-pertussis-severity-in-infants
#15
Kathleen Winter, James D Cherry, Kathleen Harriman
BACKGROUND:  All US women are recommended to receive a tetanus, diphtheria, and acellular pertussis (Tdap) vaccine at 27-36 weeks gestation during each pregnancy to reduce the risk of pertussis to their infants. The impact of this strategy on severity of disease among infected infants has not been evaluated. METHODS:  We use a retrospective cohort study design evaluating whether pertussis-infected infants born in 2011-2015 whose mothers received Tdap vaccine during pregnancy had less severe pertussis, resulting in a lower risk of hospitalization or intensive care unit admission compared with infants born to unvaccinated mothers...
September 13, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27616471/long-term-antibody-persistence-study-3-years-after-last-dose-of-the-7-valent-pneumococcal-conjugate-vaccine-in-young-children-in-china
#16
Rongcheng Li, Kong-Xiong Fang, Mariano Young, Xin Zhou, Zhangjing Chen, John Z Liang, Peter C Giardina, Daniel A Scott
BACKGROUND: In a previous study, Chinese infants were vaccinated with 7-valent pneumococcal conjugate vaccine (PCV7) ⩾7days before routine diphtheria, tetanus, and acellular pertussis vaccine (DTaP); PCV7 administered concomitantly with DTaP (PCV7+DTaP); or DTaP alone. This study examined antibody persistence at a single time point 3years after the last vaccination. METHODS: Children who participated in the prior PCV7 study were eligible to participate. A single blood sample was drawn at enrollment...
October 17, 2016: Vaccine
https://www.readbyqxmd.com/read/27612470/effectiveness-of-acellular-pertussis-vaccination-during-childhood-7%C3%A2-years-of-age-for-preventing-pertussis-in-household-contacts-1-9%C3%A2-years-old-in-catalonia-and-navarra-spain
#17
P Plans, D Toledo, M R Sala, N Camps, M Villanova, R Rodríguez, J Alvarez, R Solano, M García-Cenoz, I Barrabeig, P Godoy, S Minguell
Pertussis vaccination with 4-5 doses of acellular vaccines is recommended in Spain to all children at 2 months to 6 years of age. The effectiveness of the acellular pertussis vaccination was assessed in this study by comparing the incidence of secondary pertussis in vaccinated (4-5 doses) and unvaccinated or partially vaccinated (0-3 doses) household contacts 1-9 years old of confirmed cases of pertussis in Spain in 2012-13. Eighty-five percent of contacts had been vaccinated with 4-5 doses of acellular pertussis vaccines...
December 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27527817/a-randomized-trial-of-the-effect-of-vaccine-injection-speed-on-acute-pain-in-infants
#18
Anna Taddio, Horace Wong, Ben Welkovics, Angelo L Ilersich, Mara Cole, Morton Goldbach, Moshe Ipp
OBJECTIVE: This study compared the pain caused from fast vs. slow vaccine injections. METHODS: Infants aged 2-6months receiving primary immunizations were randomized to fast (2-4mL/s) or slow (5-10mL/s) injections during routine 0.5mL Diphtheria, Tetanus, acellular Pertussis, Inactivated Polio Virus, Haemophilus influenzae type b vaccine (DTaP-IPV-Hib) injections. Those aged 2 and 4months additionally received 0.5mL Pneumococcal Conjugate Vaccine (PCV) injections...
September 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27522178/uptake-and-timeliness-of-rotavirus-vaccination-in-norway-the-first-year-post-introduction
#19
Beatriz Valcarcel Salamanca, Maria Elisabeth Hagerup-Jenssen, Elmira Flem
BACKGROUND: To minimise vaccine-associated risk of intussusception following rotavirus vaccination, Norway adopted very strict age limits for initiating and completing the vaccine series at the time rotavirus vaccination was included in the national immunisation programme, October 2014. Although Norway has a high coverage for routine childhood vaccines, these stringent age limits could negatively affect rotavirus coverage. We documented the status and impact of rotavirus vaccination on other infant vaccines during the first year after its introduction...
September 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27510380/the-immunogenicity-and-safety-of-a-combined-dtap-ipv-hib-vaccine-compared-with-individual-dtap-ipv-and-hib-prp-t-vaccines-a-randomized-clinical-trial-in-south-korean-infants
#20
Jin Han Kang, Hoan Jong Lee, Kyung Hyo Kim, Sung Hee Oh, Sung Ho Cha, Jin Lee, Nam Hee Kim, Byung Wook Eun, Chang Hwi Kim, Young Jin Hong, Hyun Hee Kim, Kyung Yil Lee, Yae Jean Kim, Eun Young Cho, Hee Soo Kim, Fabrice Guitton, Esteban Ortiz
Recommended infant vaccination in Korea includes DTaP-IPV and Hib vaccines administered as separate injections. In this randomized, open, controlled study we assessed the non-inferiority of immunogenicity of DTaP-IPV//Hib pentavalent combination vaccine (Pentaxim™) compared with licensed DTaP-IPV and Hib (PRP~T) vaccines. We enrolled 418 healthy Korean infants to receive either separate DTaP-IPV and Hib vaccines (n = 206) or the pentavalent DTaP-IPV//Hib (n = 208) vaccine at 2, 4, 6 months of age. Antibodies to all components were measured before the first vaccination and one month after the third, and safety was assessed after each vaccination including recording of reactions by parents...
September 2016: Journal of Korean Medical Science
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