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https://www.readbyqxmd.com/read/28140752/concomitant-administration-of-diphtheria-tetanus-acellular-pertussis-and-inactivated-poliovirus-vaccine-derived-from-sabin-strains-dtap-sipv-with-pentavalent-rotavirus-vaccine-in-japanese-infants
#1
Yoshiyuki Tanaka, Ruriko Yokokawa, Han Shi Rong, Hiroyuki Kishino, Jon E Stek, Margaret Nelson, Jody Lawrence
Rotavirus is the leading cause of severe acute gastroenteritis in infants and young children. Most children are infected with rotavirus, and the health and economic burdens of rotavirus gastroenteritis on healthcare systems and families are considerable. In 2012 pentavalent rotavirus vaccine (RV5) and diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine derived from Sabin strains (DTaP-sIPV) were licensed in Japan. We examined the immunogenicity and safety of DTaP-sIPV when administrated concomitantly with RV5 in Japanese infants...
January 31, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28103212/coverage-with-tetanus-diphtheria-and-acellular-pertussis-vaccine-and-influenza-vaccine-among-pregnant-women-minnesota-march-2013-december-2014
#2
Alexandra Barber, Miriam Halstead Muscoplat, Anna Fedorowicz
Pertussis and influenza infections can result in severe disease in infants. The diphtheria, tetanus, acellular pertussis (DTaP) vaccine is recommended for infants beginning at age 2 months, and influenza vaccine is recommended for infants aged ≥6 months. Vaccination of pregnant women induces the production of antibodies that are transferred across the placenta to the fetus and provide passive protection until infants are old enough to receive DTaP and influenza vaccines (1-3). To protect young infants before they are age-eligible for vaccination, the Advisory Committee on Immunization Practices (ACIP) has recommended since 2004 that all women who are or will be pregnant during influenza season receive inactivated influenza vaccine (1), and since 2013 that all pregnant women receive the tetanus, diphtheria, acellular pertussis (Tdap) vaccine (3)...
January 20, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28097847/-nicolau-syndrome-induced-by-intramuscular-injection-of-a-hexavalent-vaccine-in-a-6-month-old-girl
#3
Paola C Stefano, Mónica Garello, María F Nolte, Patricia Lamy, Norberto Giglio, Vanesa Castellano, Ángela Gentile
Nicolau syndrome, also known as embolia cutis medicamentosa or livedo-like dermatitis, is a sudden tissue necrosis, a rare complication of intramuscular injection of some drugs. We report a case of a 6-month-old girl who received intramuscularly the third dose of hexavalent vaccine (DTaP- HVB-IPV/HIb), and immediately presented a livedoid lesion around the injection site, progressing to necrosis. We reinforce the importance of early diagnosis to perform a suitable treatment and clinical follow-up to avoid ischemic secondary complications...
1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28081174/definition-of-human-epitopes-recognized-in-tetanus-toxoid-and-development-of-an-assay-strategy-to-detect-ex-vivo-tetanus-cd4-t-cell-responses
#4
Ricardo da Silva Antunes, Sinu Paul, John Sidney, Daniela Weiskopf, Jennifer M Dan, Elizabeth Phillips, Simon Mallal, Shane Crotty, Alessandro Sette, Cecilia S Lindestam Arlehamn
Despite widespread uses of tetanus toxoid (TT) as a vaccine, model antigen and protein carrier, TT epitopes have been poorly characterized. Herein we defined the human CD4+ T cell epitope repertoire by reevaluation of previously described epitopes and evaluation of those derived from prediction of HLA Class II binding. Forty-seven epitopes were identified following in vitro TT stimulation, with 28 epitopes accounting for 90% of the total response. Despite this diverse range of epitopes, individual responses were associated with only a few immunodominant epitopes, with each donor responding on average to 3 epitopes...
2017: PloS One
https://www.readbyqxmd.com/read/28067718/immunogenicity-and-safety-of-a-booster-injection-of-dtap-ipv-hib-pentaxim%C3%A2-administered-concomitantly-with-tetravalent-dengue-vaccine-in-healthy-toddlers-aged-15-to-18-months-in-mexico-a-randomized-trial
#5
Flor Irene Rodriguez Melo, José Juan Renteria Morales, Abiel Homero Mascareñas De Los Santos, Enrique Rivas, Claire Vigne, Fernando Noriega
BACKGROUND: The live, attenuated, tetravalent dengue vaccine (CYD-TDV) is licensed in a number of dengue endemic countries for individuals ≥9 years old. Before integration of any vaccine into childhood vaccination schedules, a lack of immune interference and acceptable safety when co-administered with other recommended vaccines should be demonstrated. METHODS: This randomized, multi-center, Phase III trial was conducted in Mexico. Healthy toddlers (n=732) received a booster dose of a licensed pentavalent combination vaccine (diphtheria, tetanus, acellular pertussis, inactivated polio vaccine, and Haemophilus influenzae type b [DTaP-IPV//Hib]) either concomitantly or sequentially with the second dose of CYD-TDV administered as a 3-dose schedule...
January 6, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28038948/-immunisation-schedule-of-the-spanish-association-of-paediatrics-2017-recommendations
#6
David Moreno-Pérez, Francisco José Álvarez García, Javier Arístegui Fernández, María José Cilleruelo Ortega, José María Corretger Rauet, Nuria García Sánchez, Ángel Hernández Merino, Teresa Hernández-Sampelayo Matos, Manuel Merino Moína, Luis Ortigosa Del Castillo, Jesús Ruiz-Contreras
The Advisory Committee on Vaccines of the Spanish Association of Paediatrics (CAV- AEP) annually publishes the immunisation schedule which, in our opinion, is considered optimal for children resident in Spain, taking into account the evidence available on current vaccines. Pneumococcal and varicella immunisation in early childhood is already included in all funded vaccines present in the regional immunisation programmes. Furthermore, this committee establishes recommendations on vaccines not included in official calendars (non-funded immunisations), such as rotavirus, meningococcal B, and meningococcal ACWY...
February 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28032302/the-1925-diphtheria-antitoxin-run-to-nome-alaska-a-public-health-illustration-of-human-animal-collaboration
#7
Basil H Aboul-Enein, William C Puddy, Jacquelyn E Bowser
Diphtheria is an acute toxin-mediated superficial infection of the respiratory tract or skin caused by the aerobic gram-positive bacillus Corynebacterium diphtheriae. The epidemiology of infection and clinical manifestations of the disease vary in different parts of the world. Historical accounts of diphtheria epidemics have been described in many parts of the world since antiquity. Developed in the late 19th century, the diphtheria antitoxin (DAT) played a pivotal role in the history of public health and vaccinology prior to the advent of the diphtheria-tetanus toxoids and acellular pertussis (DTaP) vaccine...
December 29, 2016: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28017441/extensive-swelling-of-the-limb-and-systemic-symptoms-after-a-fourth-dose-of-acellular-pertussis-containing-vaccines-in-england-in-children-aged-3-6years
#8
Jo Southern, Pauline A Waight, Nick Andrews, Elizabeth Miller
Extensive limb swelling (ESL) after a booster dose of acellular pertussis (aP) containing vaccine can cause concern and has the potential to be confused with cellulitis. In the United Kingdom aP-containing vaccine was introduced for primary immunisation at 2, 3 and 4months of age in 2004, with the first cohorts eligible to receive a fourth dose in 2007 at school entry. We assessed the frequency of ESL (here defined as swelling >100mms diameter) in 973 children receiving a fourth dose of one of four aP vaccines given combined with inactivated polio, tetanus and either low dose diphtheria (TdaP/IPV) or high dose diphtheria (DTaP/IPV) vaccine; 2 of the 3 DTaP/IPV vaccines also contained Haemophilus influenza b conjugate vaccine (Hib)...
December 22, 2016: Vaccine
https://www.readbyqxmd.com/read/28011915/genome-wide-association-mapping-of-the-antibody-response-to-diphtheria-tetanus-acellular-pertussis-vaccine-in-mice
#9
Yung-Yi C Mosley, Josiah E Radder, Annerose Berndt, Harm HogenEsch
The objective of the current study was to investigate the genetics of antibody responses to an acellular pertussis vaccine (DTaP) by a genome-wide association study in mice. Female mice of 28 inbred strains received DTaP at 6, 8 and 12 weeks of age. The antibody titer and avidity of IgG specific for diphtheria toxin, pertussis toxin, filamentous hemagglutinin and pertactin were measured at 14 and 24 weeks of age. The magnitude, longevity and avidity of IgG differed significantly among mouse strains. There was significant correlation between antigen-specific IgGs for longevity, but not for magnitude and avidity...
December 23, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27996332/dtap5-ipv-hib-hepb-a-hexavalent-vaccine-for-infants-and-toddlers
#10
Andrew W Lee, Emilia Jordanov, Florence Boisnard, Gary S Marshall
Combination vaccines reduce the 'shot burden' and simplify the childhood immunization schedule. Only 5-valent DTaP-based vaccines are licensed in the U.S. Areas covered: A new combination vaccine - DTaP5-IPV-Hib-HepB - is described, which induces antibody responses in infants (given in different schedules, including a 2, 4, and 6-month schedule) that are similar to the respective component vaccines. The vaccine appears to be safe and would be expected to protect against six diseases: diphtheria, tetanus, pertussis, hepatitis B, H influenzae type b, and polio...
December 20, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27939054/concomitant-administration-of-a-fully-liquid-ready-to-use-dtap-ipv-hb-prp-t-hexavalent-vaccine-with-a-meningococcal-serogroup-c-conjugate-vaccine-in-infants
#11
Timo Vesikari, Ray Borrow, Xavier Da Costa, Patrick Richard, Cécile Eymin, Florence Boisnard, Stephen Lockhart
DTaP-IPV-HB-PRP-T or hexavalent vaccines are indicated for primary and booster vaccination of infants and toddlers against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and invasive diseases caused by Haemophilus influenzae type b (Hib). The present study evaluates the safety and immunogenicity of a ready-to-use hexavalent vaccine when co-administered with a meningococcal serogroup C conjugate (MenC) vaccine in infants. This was a phase III, open-label, randomised, multicentre study conducted in Finland...
January 11, 2017: Vaccine
https://www.readbyqxmd.com/read/27905819/mothers-preferences-regarding-new-combination-vaccines-for-their-children-in-japan-2014
#12
Aiko Shono, Masahide Kondo
A number of new vaccines to prevent childhood diseases have been introduced globally over the last few decades. Only four combination vaccines are currently available in Japan, DTaP/sIPV, DTaP, DT, and MR, leading to complex infant vaccine scheduling. This study aims to investigate mothers' preferences with respect to combination vaccines for their children, should new combination vaccines become available that have not yet been launched in Japan or that will be developed in the future. We conducted a web-based, cross-sectional survey of 1,243 mothers who had at least one child between 2 months and 3 years of age...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27891698/vaccination-and-unexplained-sudden-death-risk-in-taiwanese-infants
#13
Wan-Ting Huang, Robert T Chen, Yu-Chen Hsu, John W Glasser, Philip H Rhodes
PURPOSE: In March 1992, eight infants who had died within 36 hours of receiving whole-cell pertussis vaccine (diphtheria, tetanus, and whole-cell pertussis [DTwP]) prompted the Taiwan health authorities to suspend its use. We conducted an investigation of vaccination and sudden unexplained infant death (SUID) and repeated it more recently after Taiwan switched to acellular pertussis vaccine (diphtheria, tetanus, and acellular pertussis [DTaP]) in 2010. METHODS: All SUIDs aged 31-364 days during 1990-1992 and 1996-2013 were selected from the death registration databases...
November 28, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27889711/immunogenicity-and-safety-of-a-liquid-hexavalent-vaccine-in-indian-infants
#14
Jugesh Chhatwal, Sanjay Lalwani, Emmanuel Vidor
OBJECTIVE: To evaluate the immunogenicity and safety of a fully liquid, hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-hepatitis B-Haemophilus influenzae type b (DTaP-IPV- HB-PRP~T) vaccine in Indian infants. DESIGN: Phase III, single-arm study. SETTING: Two tertiary care hospitals. PARTICIPANTS: 177 healthy, 6-week-old infants. INTERVENTION: All participants received hepatitis B vaccine and Oral polio vaccine (OPV) at birth and DTaP-IPV-HB-PRP~T at 6, 10, 14 weeks of age...
January 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/27862309/study-of-greek-children-and-youths-with-cystic-fibrosis-identifies-immunisation-gaps-and-delays
#15
Helena C Maltezou, Stavros Doudounakis, Maria Lekaditi, Kalliopi Tanou, Panos Katerelos, Maria Theodoridou
AIM: Data about immunisation rates in cystic fibrosis (CF) patients are scarce. We estimated the rates and timeliness of immunisations in CF patients aged 0.55-22 years. METHODS: We studied 122 subjects at a hospital in Greece in 2014. A standard questionnaire was used to collect data and parents' opinions about immunisations. RESULTS: The complete immunisation rates were 92.6% for diphtheria-tetanus-acellular pertussis-inactivated poliomyelitis-Haemophilus influenzae (DTaP-IPV-Hib), 96...
February 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/27858500/undervaccination-with-diphtheria-tetanus-and-pertussis-vaccine-national-trends-and-association-with-pertussis-risk-in-young-children
#16
Wan-Ting Huang, Hui-Chen Lin, Chin-Hui Yang
BACKGROUND: The high coverage for ≥3 pertussis vaccine doses among Taiwanese children might not imply timely vaccination. Recently, resurgence of pertussis and challenges with availability of DTaP-IPV-Hib prompted this study. METHODS: In the 1996-2012 national birth cohort, we calculated the prevalence and days of undervaccination against pertussis by age 36 months. We also compared the odds of undervaccination in each laboratory-confirmed pertussis patient at ages 3-35 months with sex-, residence-, and age-matched controls from the general population, using conditional logistic regression...
November 18, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27855142/errata-vol-65-no-39
#17
(no author information available yet)
For the report, "Vaccination Coverage Among Children in Kindergarten - United States, 2015-16 School Year," on page 1061, the third sentence of the second full paragraph should read, "For example, the California Department of Public Health worked to improve vaccination coverage at schools identified from local-level data as having high levels of provisional enrollment." In addition, the fifth sentence of the same paragraph should read, "As a result, from 2014-15 to 2015-16, the number of provisionally enrolled kindergartners decreased from 36,731 (6...
November 18, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27846055/a-phase-iii-randomized-double-blind-clinical-trial-of-an-investigational-hexavalent-vaccine-given-at-2-3-4-and-12-months
#18
Timo Vesikari, Thomas Becker, Andre F Vertruyen, Katleen Poschet, Sheryl A Flores, Marco F Pagnoni, Jin Xu, G Frank Liu, Jon E Stek, Florence Boisnard, Stéphane Thomas, Eddy Ziani, Andrew W Lee
BACKGROUND: Combination vaccines simplify vaccination visits and improve coverage and timeliness. DTaP5-HB-IPV-Hib is a new investigational, fully-liquid, combination vaccine containing a 5-antigen pertussis component and which is designed to protect against 6 infectious diseases. METHODS: In this multicenter, double-blind, comparator-controlled, Phase III study (NCT01341639) conducted in Finland, Germany, and Belgium, healthy infants were randomized 1:1 to receive one of two immunization regimens...
November 11, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27810316/uptake-of-rotavirus-vaccine-among-us-infants-at-immunization-information-system-sentinel-sites
#19
Kimberly Pringle, Cristina V Cardemil, Laura J Pabst, Umesh D Parashar, Margaret M Cortese
OBJECTIVE: Coverage with rotavirus vaccine among US children has been lower compared to that with other routine childhood vaccines. Our objectives were to examine rotavirus vaccine (RV) uptake over time compared to other routine vaccinations, ages at administration, and quantitate potential missed opportunities for RV receipt. METHODS: We analyzed data from 6 Immunization Information System (IIS) Sentinel Sites, which represent approximately 10% of the United States (US) pediatric population...
December 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27753797/a-randomized-controlled-study-of-dtap-ipv-hb-prp-t-a-fully-liquid-hexavalent-vaccine-administered-in-a-3-5-and-11-to-12-month-schedule
#20
Timo Vesikari, Sven-Arne Silfverdal, Emilia Jordanov, Emmanuel Feroldi
BACKGROUND: To assess the immunogenicity and safety of a fully liquid, ready-to-use hexavalent DTaP-IPV-HB-PRP-T vaccine when administered in a 2 + 1 schedule at 3, 5 and 11-12 months of age. METHODS: Phase III, randomized, active-controlled, observer-blind, multicenter study. Infants were randomized to receive DTaP-IPV-HB-PRP-T (N = 275) or a licensed control hexavalent vaccine (DTaP-IPV-HB//PRP~T: N = 275), both given in coadministration with Prevenar 13. Serum was analyzed for immune responses to all vaccine antigens...
January 2017: Pediatric Infectious Disease Journal
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