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https://www.readbyqxmd.com/read/28719500/a-randomized-controlled-study-of-a-fully-liquid-dtap-ipv-hb-prp-t-hexavalent-vaccine-for-primary-and-booster-vaccinations-of-healthy-infants-and-toddlers-in-latin-america
#1
Pío López, Adriano Arguedas Mohs, Arturo Abdelnour Vásquez, Maria Consuelo-Miranda, Emmanuel Feroldi, Fernando Noriega, Emilia Jordanov, Siham B'Chir, Betzana Zambrano
BACKGROUND: Hexavalent diphtheria (D)-tetanus (T)-acellular pertussis (aP)-inactivated poliovirus (IPV)-hepatitis B (HB)-Haemophilus influenzae type b (PRP-T)-containing vaccines are increasingly the standard of care. This study evaluated the primary series (NCT01177722) and booster (NCT01444781) of a fully liquid DTaP-IPV-HB-PRP-T vaccine in Latin America. METHODS: Infants (N=1375) received HB vaccine at birth and were randomized to one of three batches of the investigational DTaP-IPV-HB-PRP-T or licensed control vaccine (DTaP-HB-IPV//PRP-T) at 2-4-6 months of age, co-administered with 7-valent pneumococcal conjugate vaccine (PCV7) (2-4-6 months) and rotavirus vaccine (2-4 months)...
July 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28696824/age-appropriate-versus-up-to-date-coverage-of-routine-childhood-vaccinations-among-young-children-in-israel
#2
Chen Stein-Zamir, Avi Israeli
BACKGROUND AND AIMS: Routine childhood vaccinations schedules recommend that children receive the vaccine doses at specific ages. Vaccination coverage data are conventionally reported by the up-to-date method. We aimed to assess vaccination timeliness by the age-appropriate method and compare to the up-to-date vaccination coverage. METHODS: Assessment of age-appropriate and up-to-date vaccination coverage among children born in Israel in 2009 and followed to age 48 months (national representative sample, n = 3892)...
July 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28629923/immunogenicity-and-safety-of-a-fully-liquid-dtap-ipv-hb-prp%C3%A2-t-hexavalent-vaccine-compared-with-the-standard-of-care-in-infants-in-the-republic-of-korea
#3
Yun-Kyung Kim, Emmanuel Vidor, Hwang Min Kim, Son Moon Shin, Kyung-Yil Lee, Sung-Ho Cha, Sang Hyuk Ma, Dong Ho Kim, Jin Lee, Su Eun Park, Hyunju Lee, Jong-Duk Kim, Ki Hwan Kim, Kyung-Hyo Kim, Jong-Hyun Kim
No abstract text is available yet for this article.
July 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28591046/immunogenicity-study-to-investigate-the-interchangeability-among-three-different-types-of-polio-vaccine-a-cohort-study-in-japan
#4
MULTICENTER STUDY
Satoko Ohfuji, Kazuya Ito, Motoki Ishibashi, Shizuo Shindo, Yoshio Takasaki, Takashi Yokoyama, Takato Yokoyama, Yuji Yamashita, Keigo Shibao, Takashi Nakano, Tomomi Tsuru, Shin Irie, Yoshio Hirota
In Japan, the routine immunization program with oral polio vaccine (OPV) has been suspended since September 2012, when a program with 4 doses of inactivated monovalent polio vaccine (IPV) or quadrivalent vaccine against diphtheria, pertussis, and tetanus with IPV (DTaP-IPV) was introduced. The aim of this study was to examine the interchangeability among these 3 types of polio vaccines.We conducted a prospective cohort study at 5 pediatric clinics in Japan. A total of 153 infants were assigned to 1 of the 4 groups by considering the vaccination history of OPV and trivalent vaccine against DTaP...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28557752/effectiveness-of-vaccination-during-pregnancy-to-prevent-infant-pertussis
#5
Roger Baxter, Joan Bartlett, Bruce Fireman, Edwin Lewis, Nicola P Klein
BACKGROUND: Vaccination against pertussis during pregnancy is recommended to protect newborns, yet there is limited information about the effectiveness of maternal tetanus toxoid, reduced diphtheria toxoid, acellular pertussis (Tdap) vaccine before the first infant dose of diphtheria, tetanus and acellular pertussis (DTaP) vaccine and during the first year of life in infants who have received DTaP. METHODS: In a retrospective cohort study of infants born at Kaiser Permanente Northern California from 2010 to 2015, we estimated the effectiveness of maternal pertussis vaccination for protecting newborns against pertussis in the first 2 months of life and in the first year of life accounting for each infant DTaP dose...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28506516/waning-protection-following-5-doses-of-a-3-component-diphtheria-tetanus-and-acellular-pertussis-vaccine
#6
Nicola P Klein, Joan Bartlett, Bruce Fireman, Laurie Aukes, Philip O Buck, Girishanthy Krishnarajah, Roger Baxter
BACKGROUND: The effectiveness of diphtheria, tetanus, and acellular pertussis (DTaP) vaccines wanes substantially after the 5(th) dose given at ages 4-6years, but has not been described following 5 doses of the same type of DTaP vaccine. We investigated waning effectiveness against pertussis in California over nearly 10years, which included large pertussis outbreaks, following 5 doses of GSK DTaP vaccines (DTaP3). METHODS: We conducted a case-control study (NCT02447978) of children who received 5 doses of DTaP at Kaiser Permanente Northern California from 01/2006 through 03/2015...
May 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28488995/written-reminders-increase-vaccine-coverage-in-danish-children-evaluation-of-a-nationwide-intervention-using-the-danish-vaccination-register-2014-to-2015
#7
Camilla Hiul Suppli, Mette Rasmussen, Palle Valentiner-Branth, Kåre Mølbak, Tyra Grove Krause
We evaluated a national intervention of sending written reminders to parents of children lacking childhood vaccinations, using the Danish Vaccination Register (DDV). The intervention cohort included the full birth cohort of 124,189 children born in Denmark who reached the age of 2 and 6.5 years from 15 May 2014 to 14 May 2015. The reference cohort comprised 124,427 children who reached the age of 2 and 6.5 years from 15 May 2013 to 14 May 2014. Vaccination coverage was higher in the intervention cohort at 2...
April 27, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28479179/missed-opportunities-for-simultaneous-administration-of-the-fourth-dose-of-dtap-among-children-in-the-united-states
#8
Zhen Zhao, Philip J Smith, Holly A Hill
BACKGROUND: Simultaneous administration of all age-appropriate doses of vaccines is an effective strategy for raising vaccination coverage. Vaccination coverage for ≥4 dose of DTaP (diphtheria, tetanus toxoids, and acellular pertussis vaccine) among children 19-35months in the United States has not reached the Healthy People 2020 target of 90%. Risk factors for missed opportunities for simultaneous administration of the fourth dose of DTaP have not been investigated. METHODS: A missed opportunity for simultaneous administration of the fourth dose of DTaP is defined as the failure to administer an age-eligible fourth dose of DTaP, and during the same age-eligible period for the fourth dose of DTaP other recommended and age-appropriate doses of vaccines are given to children...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28430750/elevated-immune-response-among-children-4-years-of-age-with-pronounced-local-adverse-events-after-the-fifth-dtap-vaccination
#9
Saskia van der Lee, Jeanet M Kemmeren, Lia G H de Rond, Kemal Öztürk, Anneke Westerhof, Hester E de Melker, Elisabeth A M Sanders, Guy A M Berbers, Nicoline A T van der Maas, Hans C Rümke, Anne-Marie Buisman
BACKGROUND: In the Netherlands, acellular pertussis vaccines replaced the more reactogenic whole-cell pertussis vaccines. This replacement in the primary immunization schedule of infants coincided with a significant increase in pronounced local adverse events (AEs) in 4 years old children shortly after the administration of a fifth diphtheria, tetanus, acellular pertussis and inactivated polio (DTaP-IPV) vaccine. The objective of this study was to investigate possible differences in vaccine antigen-specific immune responses between children with and without a pronounced local AE after the fifth DTaP-IPV vaccination...
April 19, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28429116/dutch-national-immunization-schedule-compliance-and-associated-characteristics-for-the-primary-series
#10
Elsemieke D Scheepers, Alies van Lier, Ingrid H Drijfhout, Guy Berbers, Nicoline A T van der Maas, Hester E de Melker, Mirjam J Knol
In the Netherlands, the recommended priming immunization schedule for diphtheria, tetanus, pertussis and polio (DTaP-IPV) is at 2, 3 and 4 months of age. We evaluated the compliance with the recommended schedule, as well as its characteristics. We included all infants born between 2007 and 2012 who received minimally one DTaP-IPV vaccination (n = 1,061,578). Infants complied with the schedule if they received the first vaccination between 6 and 9 weeks of age, and the second and third vaccination 2-6 weeks after the first and second vaccination...
April 20, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28429115/comparison-of-the-tolerability-of-newly-introduced-childhood-vaccines-in-the-netherlands
#11
Jeanet M Kemmeren, Nicoline At van der Maas, Hester E de Melker
In 2011, the 7-valent conjugated pneumococcal vaccine (PCV7) was replaced by the 10-valent vaccine (PCV10) and universal hepatitis B vaccination has been introduced in the Netherlands. A questionnaire study was conducted to assess the tolerability of DTaP-IPV-Hib + PCV7 (PCV7-cohort), DTaP-IPV-Hib + PCV10 (PCV10-cohort), and DTaP-IPV-Hib-HepB + PCV10 (HepB-cohort). Parents were asked to report in questionnaires local reactions and systemic adverse events (AEs) before and after vaccination of their infant at 2, 3, 4, and 11 months of age...
June 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28376777/assessment-of-safety-and-efficacy-against-bordetella-pertussis-of-a-new-tetanus-reduced-dose-diphtheria-acellular-pertussis-vaccine-in-a-murine-model
#12
Hyo Jin Kwon, Seung Beom Han, Bo Ram Kim, Kyu Ri Kang, Dong Ho Huh, Gi Sub Choi, Dong Ho Ahn, Jin Han Kang
BACKGROUND: Tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccination during adolescence was introduced in response to the resurgence of pertussis in various countries. A new Tdap vaccine was manufactured in Korea as a countermeasure against a predicted Tdap vaccine shortage. This study was performed to evaluate the immunogenicity, safety, and protection efficacy against Bordetella pertussis of the new Tdap vaccine in a murine model. METHODS: Four-week-old BABL/c mice were used for assessment of immunogenicity and protection efficacy...
April 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28262330/a-randomized-study-of-fever-prophylaxis-and-the-immunogenicity-of-routine-pediatric-vaccinations
#13
Jacek Wysocki, Kimberly J Center, Jerzy Brzostek, Ewa Majda-Stanislawska, Henryk Szymanski, Leszek Szenborn, Hanna Czajka, Barbara Hasiec, Jerzy Dziduch, Teresa Jackowska, Anita Witor, Elżbieta Kopińska, Ryszard Konior, Peter C Giardina, Vani Sundaraiyer, Scott Patterson, William C Gruber, Daniel A Scott, Alejandra Gurtman
OBJECTIVE: Prophylactic antipyretic use during pediatric vaccination is common. This study assessed whether paracetamol or ibuprofen prophylaxis interfere with immune responses to the 13-valent pneumococcal conjugate vaccine (PCV13) given concomitantly with the combined DTaP/HBV/IPV/Hib vaccine. METHODS: Subjects received prophylactic paracetamol or ibuprofen at 0, 6-8, and 12-16 h after vaccination, or 6-8 and 12-16 h after vaccination at 2, 3, 4, and 12months of age...
April 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28222999/effect-of-stepwise-perinatal-immunization-education-a-cluster-randomized-controlled-trial
#14
Aya Saitoh, Akihiko Saitoh, Isamu Sato, Tomohiro Shinozaki, Hajime Kamiya, Satoko Nagata
BACKGROUND: Perinatal immunization education is important for improving the immunization outcomes of infants; however, the content of educational materials used at each perinatal period has not been carefully evaluated. We hypothesized that stepwise education offered at different perinatal periods would improve infant immunization status and enhance maternal immunization knowledge. METHODS: In this cluster-randomized controlled trial, pregnant women were recruited from nine obstetric sites in Niigata, Japan...
February 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28221240/the-residual-vaccine-preventable-burden-of-rotavirus-disease
#15
Bethany K Sederdahl, Jumi Yi, Robert Jerris, Scott E Gillespie, Lars Westblade, Colleen S Kraft, Andi L Shane, Ben Lopman, Evan J Anderson
From July 2007 to June 2015, 61% of rotavirus-positive, vaccine-eligible children were unvaccinated for rotavirus. Of these, 67% of children had received diphtheria-tetanus toxoids-acellular pertussis within the recommended age for rotavirus vaccine initiation. Improving linkage between rotavirus and diphtheria-tetanus toxoids-acellular pertussis administration may impact the residual burden of US rotavirus disease.
August 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28218995/effects-of-rapid-vaccine-injection-without-aspiration-and-applying-manual-pressure-before-vaccination-on-pain-and-crying-time-in-infants
#16
İlknur Göl, Süheyla Altuğ Özsoy
AIM: To compare effects of rapid injection without aspiration and 10-second manual pressure before injection on pain severity and crying time in 4- to 6-month-old infants given the vaccine DTaP/IPV/Hib. METHODS: This is a randomized double-blind controlled study. The study population included all the infants presenting for DTaP/IPV/Hib to two family health centers between April and August in 2015. The study sample included 128 infants based on confidence interval of 95% and statistical power of 80%...
April 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28140752/concomitant-administration-of-diphtheria-tetanus-acellular-pertussis-and-inactivated-poliovirus-vaccine-derived-from-sabin-strains-dtap-sipv-with-pentavalent-rotavirus-vaccine-in-japanese-infants
#17
Yoshiyuki Tanaka, Ruriko Yokokawa, Han Shi Rong, Hiroyuki Kishino, Jon E Stek, Margaret Nelson, Jody Lawrence
Rotavirus is the leading cause of severe acute gastroenteritis in infants and young children. Most children are infected with rotavirus, and the health and economic burdens of rotavirus gastroenteritis on healthcare systems and families are considerable. In 2012 pentavalent rotavirus vaccine (RV5) and diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine derived from Sabin strains (DTaP-sIPV) were licensed in Japan. We examined the immunogenicity and safety of DTaP-sIPV when administrated concomitantly with RV5 in Japanese infants...
June 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28103212/coverage-with-tetanus-diphtheria-and-acellular-pertussis-vaccine-and-influenza-vaccine-among-pregnant-women-minnesota-march-2013-december-2014
#18
Alexandra Barber, Miriam Halstead Muscoplat, Anna Fedorowicz
Pertussis and influenza infections can result in severe disease in infants. The diphtheria, tetanus, acellular pertussis (DTaP) vaccine is recommended for infants beginning at age 2 months, and influenza vaccine is recommended for infants aged ≥6 months. Vaccination of pregnant women induces the production of antibodies that are transferred across the placenta to the fetus and provide passive protection until infants are old enough to receive DTaP and influenza vaccines (1-3). To protect young infants before they are age-eligible for vaccination, the Advisory Committee on Immunization Practices (ACIP) has recommended since 2004 that all women who are or will be pregnant during influenza season receive inactivated influenza vaccine (1), and since 2013 that all pregnant women receive the tetanus, diphtheria, acellular pertussis (Tdap) vaccine (3)...
January 20, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28097847/-nicolau-syndrome-induced-by-intramuscular-injection-of-a-hexavalent-vaccine-in-a-6-month-old-girl
#19
Paola C Stefano, Mónica Garello, María F Nolte, Patricia Lamy, Norberto Giglio, Vanesa Castellano, Ángela Gentile
Nicolau syndrome, also known as embolia cutis medicamentosa or livedo-like dermatitis, is a sudden tissue necrosis, a rare complication of intramuscular injection of some drugs. We report a case of a 6-month-old girl who received intramuscularly the third dose of hexavalent vaccine (DTaP- HVB-IPV/HIb), and immediately presented a livedoid lesion around the injection site, progressing to necrosis. We reinforce the importance of early diagnosis to perform a suitable treatment and clinical follow-up to avoid ischemic secondary complications...
February 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28081174/definition-of-human-epitopes-recognized-in-tetanus-toxoid-and-development-of-an-assay-strategy-to-detect-ex-vivo-tetanus-cd4-t-cell-responses
#20
Ricardo da Silva Antunes, Sinu Paul, John Sidney, Daniela Weiskopf, Jennifer M Dan, Elizabeth Phillips, Simon Mallal, Shane Crotty, Alessandro Sette, Cecilia S Lindestam Arlehamn
Despite widespread uses of tetanus toxoid (TT) as a vaccine, model antigen and protein carrier, TT epitopes have been poorly characterized. Herein we defined the human CD4+ T cell epitope repertoire by reevaluation of previously described epitopes and evaluation of those derived from prediction of HLA Class II binding. Forty-seven epitopes were identified following in vitro TT stimulation, with 28 epitopes accounting for 90% of the total response. Despite this diverse range of epitopes, individual responses were associated with only a few immunodominant epitopes, with each donor responding on average to 3 epitopes...
2017: PloS One
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