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https://www.readbyqxmd.com/read/29453640/effect-of-semi-rapid-maxillary-expansion-in-children-with-obstructive-sleep-apnea-syndrome-5-month-follow-up-study
#1
Saimir Hoxha, Ecem Kaya-Sezginer, Filiz Bakar-Ates, Oğuz Köktürk, Ufuk Toygar-Memikoğlu
BACKGROUND: The purpose of this study was to investigate the effect of semi-rapid maxillary expansion (SRME) orthodontic treatment on biomarkers and respiratory parameters in children with obstructive sleep apnea syndrome (OSAS) and maxillary transverse deficiency. METHODS: Thirty children with OSAS were included in this study. Fifteen children were enrolled as control, and 15 children were subjected to SRME orthodontic treatment method for 5 months. Beside respiratory parameters, pharyngeal area, dental arch, and postero-anterior widths and the levels of OSAS biomarkers in serum and urine were measured...
February 17, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29453637/cough-hypersensitivity-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#2
Cuiqin Shi, Siwei Liang, Xianghuai Xu, Qiang Chen, Lan Wang, Li Yu, Hanjing Lv, Zhongmin Qiu
PURPOSE: The purpose of this study was to investigate cough hypersensitivity and its potential mechanisms in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS: Fifteen OSAHS patients, 12 simple snoring patients, and 15 healthy volunteers received cough sensitivity test and induced sputum cytology. Cough thresholds C2 and C5 (the minimum of capsaicin inducing ≥ 2 and ≥ 5 coughs, respectively), total cell count, cell differentials and the levels of bradykinin, histamine, prostaglandin E 2 , substance P, calcitonin gene-related peptide, pepsin, and interleukin-2 in the induced sputum detected by enzyme-linked immunosorbent assay were compared...
February 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29450504/association-of-adenotonsillectomy-with-blood-pressure-among-hypertensive-and-nonhypertensive-children-with-obstructive-sleep-apnea
#3
Cho-Hsueh Lee, Kun-Tai Kang, Shuenn-Nan Chiu, I-Sheng Chang, Wen-Chin Weng, Pei-Lin Lee, Wei-Chung Hsu
Importance: Hypertension in childhood may continue into adulthood and lead to adverse cardiovascular outcomes. Evidence suggests that adenotonsillectomy for childhood obstructive sleep apnea (OSA) may be associated with blood pressure (BP) improvement. However, how adenotonsillectomy is associated with BP in hypertensive and nonhypertensive children with OSA remains unclear. Objective: To investigate disparities in BP changes after adenotonsillectomy in hypertensive and nonhypertensive children with OSA...
February 15, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29449609/kinesthetic-stimulation-for-obstructive-sleep-apnea-syndrome-an-on-off-proof-of-concept-trial
#4
Alfredo I Hernández, Diego Pérez, Delphine Feuerstein, Corinne Loiodice, Laurence Graindorge, Gustavo Guerrero, Nadège Limousin, Frédéric Gagnadoux, Yves Dauvilliers, Renaud Tamisier, Arnaud Prigent, Philippe Mabo, Amel Amblard, Lotfi Senhadji, Jean-Louis Pépin
Obstructive sleep apnea (OSA) occurs when the upper airway narrows or collapses due to the loss of upper airway muscle activation at sleep onset. This study investigated the effectiveness of triggered kinesthetic stimulation in patients with OSA. This proof-of-concept, open-label, multicenter prospective study was conducted on 24 patients with severe OSA. During a one night evaluation, kinesthetic stimulation was intermittently delivered in 30 minute periods. The duration of apneas and hypopneas during Stim on and Stim off periods were compared...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29447889/correlations-between-pediatric-obstructive-sleep-apnea-and-longitudinal-growth
#5
Do-Yang Park, Ji Ho Choi, So Young Kang, Jinjoo Han, Hun Yi Park, Jin Soon Hwang, Jae Ho Cho, Min Hyuk Cho, Hyun Jun Kim
OBJECTIVES: Pediatric obstructive sleep apnea has a relatively high prevalence and has various negative health and behavioral consequences. Among the various complications of pediatric obstructive sleep apnea, growth disturbance is still controversial. METHOD: 745 pediatric subjects with obstructive sleep apnea diagnosed by in-lab polysomnography were enrolled, after excluding ineligible subjects with abnormal growth related factors. Height, weight, and BMI of enrolled patients were measured and statistically converted to z-scores, and the converted data were analyzed statistically with the polysomnographic results...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447819/lingual-tonsillectomy-in-children-with-down-syndrome-is-it-safe
#6
Jonathan R Skirko, Emily L Jensen, Norman R Friedman
OBJECTIVE: Evaluate peri-operative course and morbidity in children with Down syndrome (DS) who underwent a lingual tonsillectomy (LT) for residual obstructive sleep apnea (rOSA). METHODS: Retrospective case series for children with DS who underwent LT for rOSA from April 2011 to July 2016. Our primary outcomes were length of stay, readmission and complications. Surgical effectiveness was evaluated by change in the obstructive apnea-hypopnea-index(OAHI) and oxygen saturation nadir...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29445536/predictors-of-long-term-adherence-to-continuous-positive-airway-pressure-in-patients-with-obstructive-sleep-apnoea-and-acute-coronary-syndrome
#7
Marina Florés, Montserrat Martinez-Alonso, Alicia Sánchezde-la-Torre, Albina Aldomà, Estefania Galera, Ferran Barbé, Manuel Sánchezde-la-Torre, Mireia Dalmases
Background: Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnoea (OSA), but an evaluation of CPAP adherence is rarely carried out among patients with acute coronary syndrome (ACS). The goals of the study are to analyse long-term adherence and identify the predictors of non-compliance with CPAP treatment for patients with non-sleepy OSA and ACS. Methods: This is an ancillary study of the ISAACC study, which is a multicentre, prospective, open-label, parallel, randomized, and controlled trial (NCT01335087) in patients with hospital admission for ACS...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29445282/orexin-hypocretin-levels-in-the-cerebrospinal-fluid-and-characteristics-of-patients-with-myotonic-dystrophy-type-1-with-excessive-daytime-sleepiness
#8
Yuki Omori, Takashi Kanbayashi, Aya Imanishi, Ko Tsutsui, Yohei Sagawa, Yuka S Kikuchi, Masahiro Takeshima, Kazuhisa Yoshizawa, Sachiko Uemura, Tetsuo Shimizu
Purpose: Myotonic dystrophy type 1 (DM1) is often characterized by excessive daytime sleepiness (EDS) and sleep-onset rapid eye movement periods caused by muscleblind-like protein 2. The EDS tends to persist even after treatment of sleep apnea. We measured the cerebrospinal fluid (CSF) orexin levels in DM1 patients with EDS and compared the clinical characteristics with narcolepsy type 1 and idiopathic hypersomnia (IHS) patients. Patients and methods: We measured the CSF orexin levels in 17 DM1 patients with EDS and evaluated subjective sleepiness using the Epworth Sleepiness Scale (ESS), objective sleepiness using mean sleep latency (MSL), and sleep apnea using apnea-hypopnea index (AHI)...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29444292/determinants-of-sleepiness-in-obstructive-sleep-apnea
#9
Bharati Prasad, Alana D Steffen, Hans P A Van Dongen, Francis M Pack, Inna Strakovsky, Bethany Staley, David F Dinges, Greg Maislin, Allan I Pack, Terri E Weaver
Study Objectives: Significant interindividual variability in sleepiness is observed in clinical populations with obstructive sleep apnea (OSA). This phenomenon is only partially explained by the apnea-hypopnea index (AHI). Understanding factors that lead to sleepiness is critical to effective management of patients with OSA. We examined demographic and other factors associated with sleepiness in OSA. Methods: Prospective study of 283 patients with newly diagnosed OSA by polysomnography (AHI ≥ 5 per hour)...
February 10, 2018: Sleep
https://www.readbyqxmd.com/read/29441807/alterations-of-igf-1-complement-c3-and-superoxide-dismutase-in-patients-with-moderate-to-severe-obstructive-sleep-apnea-hypopnea-syndrome
#10
Xiao Wang, Yufeng Wang, Zechuan Cai, Xiaoxia Lu, Zhenxing Li, Yun Chen, Guoliang Zu, Taoping Li
AIM: To evaluate various biomarkers of metabolism, immunity and inflammation in obstructive sleep apnea hypopnea syndrome (OSAHS). MATERIALS & METHODS: After overnight polysomnography, blood was collected from 292 OSAHS patients or healthy volunteers. Serum content of inflammatory, immune, metabolic biomarkers were investigated. In addition, the effects of 1-month continuous positive airway pressure (CPAP) were studied in moderate/severe OSAHS. RESULTS: C3, serum total complement activity, superoxide dismutase, uric acid were significantly higher in moderate/severe OSAHS than that in no/mild OSAHS...
February 14, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29440942/mandibular-positioning-techniques-to-improve-sleep-quality-in-patients-with-obstructive-sleep-apnea-current-perspectives
#11
REVIEW
Sofie Wilkens Knappe, Liselotte Sonnesen
The purpose of this article is to review 1) mandibular advancement device (MAD) - indication, treatment success, and side effects; 2) maxillomandibular advancement (MMA) surgery of the jaws - indication, treatment success, and side effects; and 3) current perspectives. Both MAD and MMA are administered to increase the upper airway volume and reduce the collapsibility of the upper airway. MAD is noninvasive and is indicated as a first-stage treatment in adult patients with mild-to-moderate obstructive sleep apnea (OSA) and in patients with severe OSA unable to adhere to continuous positive airway pressure (CPAP)...
2018: Nature and Science of Sleep
https://www.readbyqxmd.com/read/29434497/cerebellar-ganglioglioma-in-childhood-histopathologic-implications-for-management-during-long-term-survival-a-case-report
#12
Koyo Ohno, Yoshiaki Saito, Akiko Tamasaki-Kondo, Atsushi Kambe, Yasushi Horie, Shinsuke Kato, Yoshihiro Maegaki
We report the case of a 19-year-old female with cerebellar ganglioglioma that was diagnosed at 4 years of age. Despite treatment with partial resection, radiation, and chemotherapy, residual tumor slowly expanded into the brainstem and upper cervical cord, resulting in nocturnal hypopnea, progressive tetraparesis, and feeding difficulty during 8-10 years of age. Initiation of temozolomide and bevacizumab was effective in preventing further expansion of the tumor, and the patient has been treated at home and in school with noninvasive positive pressure ventilation and gastrostomy...
December 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/29428326/a-modified-definition-for-obstructive-sleep-apnea-in-home-sleep-apnea-testing-after-stroke-or-transient-ischemic-attack
#13
Namita Patel, Afsaneh Raissi, Sara Elias, Maneesha Kamra, Tetyana Kendzerska, Brian J Murray, Mark I Boulos
BACKGROUND: Home sleep apnea testing (HSAT) underestimates obstructive sleep apnea (OSA) severity. Overnight oxygen desaturation has been shown to be a strong predictor of incident stroke, and may be helpful in determining which patients with lower apnea-hypopnea indices (AHIs) should be offered treatment. OBJECTIVES: To examine whether a modified definition for OSA that uses oxygen desaturation (i.e., AHI 5-14.9 per hour and lowest O2 desaturation ≤88%), as compared to an AHI ≥ 15 per hour, would impact: (1) changes in Epworth Sleepiness Scale scores post-continuous positive airway pressure (CPAP) initiation; (2) CPAP compliance rates; and (3) the accuracy of automated versus manual scoring of HSAT...
February 7, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29428066/utility-of-bispectrum-in-the-screening-of-pediatric-sleep-apnea-hypopnea-syndrome-using-oximetry-recordings
#14
Fernando Vaquerizo-Villar, Daniel Álvarez, Leila Kheirandish-Gozal, Gonzalo César Gutiérrez-Tobal, Verónica Barroso-García, Andrea Crespo, Félix Del Campo, David Gozal, Roberto Hornero
BACKGROUND AND OBJECTIVE: The aim of this study was to assess the utility of bispectrum-based oximetry approaches as a complementary tool to traditional techniques in the screening of pediatric sleep apnea-hypopnea syndrome (SAHS). METHODS: 298 blood oxygen saturation (SpO 2 ) signals from children ranging 0-13 years of age were recorded during overnight polysomnography (PSG). These recordings were divided into three severity groups according to the PSG-derived apnea hypopnea index (AHI): AHI < 5 events per hour (e/h), 5 ≤ AHI < 10 e/h, AHI ≥ 10 e/h...
March 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29425754/does-the-medical-comorbidity-profile-of-obstructive-sleep-apnea-patients-treated-with-maxillomandibular-advancement-differ-from-that-of-obstructive-sleep-apnea-patients-managed-nonsurgically
#15
Richard Ngo, Elaina Pullano, Zachary S Peacock, Edward T Lahey, Meredith August
PURPOSE: Obstructive sleep apnea (OSA) patients with retrognathia and measurable anatomic airway determinants may represent a subset of OSA patients and have distinct comorbidity profiles. Our aim was to compare the medical comorbidities of OSA patients managed surgically with maxillomandibular advancement with those of nonsurgical patients. PATIENTS AND METHODS: In this cross-sectional retrospective study, patients for both cohorts were identified through the Massachusetts General Hospital oral and maxillofacial surgery data registry and the Massachusetts General Hospital Research Patient Data Registry...
January 31, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29425579/the-impact-of-sleep-disordered-breathing-on-cardiovascular-health-in-overweight-children
#16
Rosemary S C Horne, Genevieve Shandler, Knarik Tamanyan, Aidan Weichard, Alexsandria Odoi, Sarah N Biggs, Margot J Davey, Gillian M Nixon, Lisa M Walter
BACKGROUND: Up to 50% of overweight/obese children have obstructive sleep apnea (OSA) compared to up to 6% of normal weight children. We compared cardiovascular variables between normal weight and overweight/obese children with and without OSA, and controls. METHODS: Seventy-four referred children and 24 normal weight non-snoring controls (8-18 years) were recruited. Referred children were grouped according to their obstructive apnea hypopnea index (OAHI): OSA (>1 event/h) or primary snoring (PS ≤ 1 event/h) and whether they were normal weight (BMI z-score <1...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29425575/effect-of-a-patient-engagement-tool-on-positive-airway-pressure-adherence-analysis-of-a-german-healthcare-provider-database
#17
Holger Woehrle, Michael Arzt, Andrea Graml, Ingo Fietze, Peter Young, Helmut Teschler, Joachim H Ficker
OBJECTIVE/BACKGROUND: This study investigated the addition of a real-time feedback patient engagement tool on positive airway pressure (PAP) adherence when added to a proactive telemedicine strategy. PATIENTS/METHODS: Data from a German healthcare provider (ResMed Healthcare Germany) were retrospectively analyzed. Patients who first started PAP therapy between 1 September 2009 and 30 April 2014, and were managed using telemedicine (AirView™; proactive care) or telemedicine + patient engagement tool (AirView™ + myAir™; patient engagement) were eligible...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29425355/an-initial-report-of-sleep-disorders-in-women-in-the-u-s-military
#18
Dale C Capener, Matthew S Brock, Shana L Hansen, Panagiotis Matsangas, Vincent Mysliwiec
Introduction: Sleep disorders are increasingly recognized in active duty service members (ADSM). While there are multiple studies in male ADSM, there are limited data regarding sleep disorders in women in the military. The purpose of this study was to characterize sleep disorders in female ADSM referred for clinical evaluation to provide a better understanding of this unique population. Materials and Methods: We conducted a retrospective review of female ADSM who underwent a sleep medicine evaluation and an attended polysomnogram (PSG)...
February 7, 2018: Military Medicine
https://www.readbyqxmd.com/read/29423748/evaluation-of-the-success-of-obstructive-sleep-apnea-surgery-using-criteria-based-on-long-term-symptoms-and-incident-hypertension
#19
Jae Hyun Lim, Pona Park, Jee Hye Wee, January E Gelera, Kundan Kumar Shrestha, Chae-Seo Rhee, Jeong-Whun Kim
OBJECTIVE: To identify appropriate success criteria, based on long-term symptoms and incident hypertension, after surgery for obstructive sleep apnea (OSA). METHODS: This observational cohort study included 97 adult OSA patients (90 men) who underwent surgical treatment at our tertiary medical center. Subjective symptoms [witnessed sleep apnea and snoring, and Epworth sleepiness scale (ESS) scores] were evaluated through a telephone survey, and incident hypertension was assessed from medical records...
February 8, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29422340/diagnosing-sleep-apnea-hypopnea-syndrome-in-children-past-present-and-future
#20
Pablo E Brockmann, María Luz Alonso-Álvarez, David Gozal
No abstract text is available yet for this article.
February 5, 2018: Archivos de Bronconeumología
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