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https://www.readbyqxmd.com/read/27910408/universal-handheld-micropipette
#1
Justin Beroz, A John Hart
The handheld micropipette is the most ubiquitous instrument for precision handling of microliter-milliliter liquid volumes, which is an essential capability in biology and chemistry laboratories. The range of one pipette is typically adjustable up to 10-fold its minimum volume, requiring the use and maintenance of multiple pipettes for liquid handling across larger ranges. Here we propose a design for a single handheld pipette adjustable from 0.1 μl to 1000 μl (i.e., 10(4)-fold) which spans the range of an entire suite of current commercial pipettes...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909940/enhancement-of-rapamycin-production-by-metabolic-engineering-in-streptomyces-hygroscopicus-based-on-genome-scale-metabolic-model
#2
Lanqing Dang, Jiao Liu, Cheng Wang, Huanhuan Liu, Jianping Wen
Rapamycin, as a macrocyclic polyketide with immunosuppressive, antifungal, and anti-tumor activity produced by Streptomyces hygroscopicus, is receiving considerable attention for its significant contribution in medical field. However, the production capacity of the wild strain is very low. Hereby, a computational guided engineering approach was proposed to improve the capability of rapamycin production. First, a genome-scale metabolic model of Streptomyces hygroscopicus ATCC 29253 was constructed based on its annotated genome and biochemical information...
December 1, 2016: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27909528/influence-of-inter-electrode-atrial-lead-distance-on-acapconfirm%C3%A2-viability
#3
Lapuerta Irigoyen J A, Valverde Andre I, Vigil Escalera P, Gonzalez Vasserot M
Introduction: The AcapConfirm™ feature available with the Zephyr pacemaker family (St. Jude Medical) is designed for monitoring patient's atrial capture threshold periodically, and automatically adjusting the atrial pulse amplitude. Previous studies showed a relative low proportion of patients at three months follow-up with recommended automatic atrial capture after the AcapConfirm™ viability test. The purpose of the present study is to evaluate the effect of inter electrode distance on the viability of the AcapConfirm™ algorithm...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27908182/prostate-deformation-from-inflatable-rectal-probe-cover-and-dosimetric-effects-in-prostate-seed-implant-brachytherapy
#4
Jun Lian, Yeqin Shao, Larry D Potter, Ronald C Chen, Jordan A Holmes, Eleanor A Pryser, Jie Shen, Dinggang Shen, Andrew Z Wang
PURPOSE: Prostate brachytherapy is an important treatment technique for patients with localized prostate cancer. An inflatable rectal ultrasound probe cover is frequently utilized during the procedure to adjust for unfavorable prostate position relative to the implant grid. However, the inflated cover causes prostate deformation, which is not accounted for during dosimetric planning. Most of the therapeutic dose is delivered after the procedure when the prostate and surrounding organs-at-risk are less deformed...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27905829/post-traumatic-stress-disorder-dimensions-and-asthma-morbidity-in-world-trade-center-rescue-and-recovery-workers
#5
Irina Mindlis, Esperanza Morales-Raveendran, Emily Goodman, Kevin Xu, Clara Vila-Castelar, Kristine Keller, Ginger Crawford, Shynah James, Craig Katz, Laura E Crowley, Rafael E de la Hoz, Steven Markowitz, Juan P Wisnivesky
Objective Using data from a cohort of World Trade Center (WTC) rescue and recovery workers with asthma, we assessed whether meeting criteria for post-traumatic stress disorder (PTSD), sub- PTSD and for specific PTSD symptom dimensions are associated with increased asthma morbidity. Methods Participants underwent a Structured Clinical Interview for Diagnostic and Statistical Manual to assess presence of PTSD following DSM-IV criteria during in-person interviews between December 2013 and April 2015. We defined sub-threshold PTSD as meeting criteria for two of three symptom dimensions: re-experiencing, avoidance, or hyper-arousal...
December 1, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27905172/recommendations-for-pathologic-staging-ptnm-of-cancer-of-the-esophagus-and-esophagogastric-junction-for-the-8th-edition-ajcc-uicc-staging-manuals
#6
T W Rice, H Ishwaran, W L Hofstetter, D P Kelsen, C Apperson-Hansen, E H Blackstone
We report analytic and consensus processes that produced recommendations for pathologic stage groups (pTNM) of esophageal and esophagogastric junction cancer for the AJCC/UICC cancer staging manuals, 8th edition. The Worldwide Esophageal Cancer Collaboration provided data for 22,654 patients with epithelial esophageal cancers; 13,300 without preoperative therapy had pathologic assessment after esophagectomy or endoscopic treatment. Risk-adjusted survival for each patient was developed using random survival forest analysis to identify data-driven pathologic stage groups wherein survival decreased monotonically with increasing group, was distinctive between groups, and homogeneous within groups...
November 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27905171/recommendations-for-clinical-staging-ctnm-of-cancer-of-the-esophagus-and-esophagogastric-junction-for-the-8th-edition-ajcc-uicc-staging-manuals
#7
Thomas W Rice, Hemant Ishwaran, Eugene H Blackstone, Wayne L Hofstetter, David P Kelsen, Carolyn Apperson-Hansen
We report analytic and consensus processes that produced recommendations for clinical stage groups (cTNM) of esophageal and esophagogastric junction cancer for the AJCC/UICC cancer staging manuals, 8th edition. The Worldwide Esophageal Cancer Collaboration (WECC) provided data on 22,123 clinically staged patients with epithelial esophageal cancers. Risk-adjusted survival for each patient was developed using random survival forest analysis from which (1) data-driven clinical stage groups were identified wherein survival decreased monotonically and was distinctive between and homogeneous within groups and (2) data-driven anatomic clinical stage groups based only on cTNM...
November 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27905170/recommendations-for-neoadjuvant-pathologic-staging-yptnm-of-cancer-of-the-esophagus-and-esophagogastric-junction-for-the-8th-edition-ajcc-uicc-staging-manuals
#8
Thomas W Rice, Hemant Ishwaran, David P Kelsen, Wayne L Hofstetter, Carolyn Apperson-Hansen, Eugene H Blackstone
We report analytic and consensus processes that produced recommendations for neoadjuvant pathologic stage groups (ypTNM) of esophageal and esophagogastric junction cancer for the AJCC/UICC cancer staging manuals, 8th edition. The Worldwide Esophageal Cancer Collaboration provided data for 22,654 patients with epithelial esophageal cancers; 7,773 had pathologic assessment after neoadjuvant therapy. Risk-adjusted survival for each patient was developed. Random forest analysis identified data-driven neoadjuvant pathologic stage groups wherein survival decreased monotonically with increasing group, was distinctive between groups, and homogeneous within groups...
November 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27903295/prevalence-and-risk-factors-of-periodontal-disease-among-pre-conception-chinese-women
#9
Hong Jiang, Yi Su, Xu Xiong, Emily Harville, Hongqiao Wu, Zhijun Jiang, Xu Qian
BACKGROUND: Periodontal disease is one of the most common chronic infectious diseases. It has been reported that periodontal disease is associated with various adverse pregnancy outcomes including preterm birth, low birth weight, and gestational diabetes mellitus. Given the fact that the treatment for periodontal disease during pregnancy was ineffective in improving pregnancy outcomes by most of studies, the pre-conception period has been put forward as a more optimal time. However, very few studies have reported the prevalence of periodontal disease among pre-conception women...
December 1, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27898387/a-novel-adaboost-framework-with-robust-threshold-and-structural-optimization
#10
Peng-Bo Zhang, Zhi-Xin Yang
The AdaBoost algorithm is a popular ensemble method that combines several weak learners to boost generalization performance. However, conventional AdaBoost.RT algorithms suffer from the limitation that the threshold value must be manually specified rather than chosen through a self-adaptive mechanism, which cannot guarantee a result in an optimal model for general cases. In this paper, we present a generic AdaBoost framework with robust threshold mechanism and structural optimization on regression problems...
November 24, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27893003/navigation-guidance-during-free-flap-mandibular-reconstruction-a-cadaveric-trial
#11
R Alex Harbison, Xiao-Feng Shan, Zachary Douglas, Scott Bevans, Yangming Li, Kris S Moe, Neal Futran, Jeffrey J Houlton
Importance: Segmental mandibulectomy for tumors that distort the buccal surface of the mandible present a reconstructive challenge. Objective: To determine whether mandible alignment after navigation-guided mandible reconstruction is better than alignment after non-template-assisted freehand reconstruction and as good as template-assisted reconstruction in a cadaveric trial. Design, Setting, and Participants: A cadaveric trial using 10 specimens was conducted at a tertiary academic center...
November 17, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27891513/clinic-predictive-factors-for-insufficient-myocardial-reperfusion-in-st-segment-elevation-myocardial-infarction-patients-treated-with-selective-aspiration-thrombectomy-during-primary-percutaneous-coronary-intervention
#12
Jinfan Tian, Yue Liu, Xiantao Song, Min Zhang, Feng Xu, Fei Yuan, Shuzheng Lyu
Background. Insufficient data are available on the potential benefit of selective aspiration and clinical predictors for no-reflow in STEMI patients undergoing primary percutaneous coronary intervention (PPCI) adjunct with aspiration thrombectomy. Objective. The aim of our study was to investigate clinical predictors for insufficient reperfusion in patients with high thrombus burden treated with PPCI and manual aspiration thrombectomy. Methods. From January 2011 till December 2015, 277 STEMI patients undergoing manual aspiration thrombectomy and PPCI were selected and 202 patients with a Thrombolysis in Myocardial Infarction (TIMI) thrombus grade 4~5 were eventually involved in our study...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27888421/triple-negative-breast-cancer-has-worse-overall-survival-and-cause-specific-survival-than-non-triple-negative-breast-cancer
#13
Xiaoxian Li, Jing Yang, Limin Peng, Aysegul A Sahin, Lei Huo, Kevin C Ward, Ruth O'Regan, Mylin A Torres, Jane L Meisel
PURPOSE: The current American Joint Committee on Cancer (AJCC) staging manual uses tumor size, lymph node, and metastatic status to stage breast cancer across different subtypes. We examined the prognosis of triple-negative breast cancer (TNBC) versus non-TNBC within the same stages and sub-stages to evaluate whether TNBC had worse prognosis than non-TNBC. METHODS: We reviewed the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) data and identified 158,358 patients diagnosed with breast cancer from 2010 to 2012...
November 25, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27881424/temporal-reduction-in-chronotropic-index-predicts-risk-of-cardiovascular-death-among-healthy-middle-aged-men-a-28-year-follow-up-study
#14
Kristian Engeseth, Christian Hodnesdal, Irene Grundvold, Knut Liestøl, Knut Gjesdal, Sverre E Kjeldsen, Jan E Erikssen, Johan Bodegard, Per Torger Skretteberg
BACKGROUND: Chronotropic index is a standardized measure of heart rate (HR) increment during exercise that reflects the combined effects of age, resting HR, and physical fitness. Low chronotropic index has been reported to predict disease and death. We tested whether temporal change in chronotropic index over 7 years influenced risk of cardiovascular death through up to 28 years. METHODS AND RESULTS: Chronotropic index was calculated ([achieved maximal HR-resting HR]/[age-predicted maximal HR-resting HR]) after a symptom-limited bicycle ECG exercise test in 1420 healthy men at 2 examinations 7 years apart, in 1972 and 1979...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27875364/attenuation-of-choroidal-thickness-in-patients-with-alzheimer-disease-evidence-from-an-italian-prospective-study
#15
Alessandro Trebbastoni, Michela Marcelli, Fabiana Mallone, Fabrizia D'Antonio, Letizia Imbriano, Alessandra Campanelli, Carlo de Lena, Magda Gharbiya
INTRODUCTION: To compare the 12-month choroidal thickness (CT) change between Alzheimer disease (AD) patients and normal subjects. METHODS: In this prospective, observational study, 39 patients with a diagnosis of mild to moderate AD and 39 age-matched control subjects were included. All the subjects underwent neuropsychological (Mini Mental State Examination, Alzheimer disease Assessment Scale-Cognitive Subscale, and the Clinical Dementia Rating Scale) and ophthalmological evaluation, including spectral domain optical coherence tomography, at baseline and after 12 months...
November 21, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27875140/vismatchmaker-cooperation-of-the-user-and-the-computer-in-centralized-matching-adjustment
#16
Po-Ming Law, Wenchao Wu, Yixian Zheng, Huamin Qu
Centralized matching is a ubiquitous resource allocation problem. In a centralized matching problem, each agent has a preference list ranking the other agents and a central planner is responsible for matching the agents manually or with an algorithm. While algorithms can find a matching which optimizes some performance metrics, they are used as a black box and preclude the central planner from applying his domain knowledge to find a matching which aligns better with the user tasks. Furthermore, the existing matching visualization techniques (i...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27873549/a-systematic-review-of-recommended-modifications-of-cbt-for-people-with-cognitive-impairments-following-brain-injury
#17
Melanie Gallagher, Hamish J McLeod, Thomas M McMillan
Due to diverse cognitive, emotional and interpersonal changes that can follow brain injury, psychological therapies often need to be adapted to suit the complex needs of this population. The aims of the study were to synthesise published recommendations for therapy modifications following brain injury from non-progressive traumatic, vascular, or metabolic causes and to determine how often such modifications have been applied to cognitive behavioural therapy (CBT) for post-injury emotional adjustment problems...
November 22, 2016: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/27865119/does-haptic-steering-guidance-instigate-speeding-a-driving-simulator-study-into-causes-and-remedies
#18
T Melman, J C F de Winter, D A Abbink
An important issue in road traffic safety is that drivers show adverse behavioral adaptation (BA) to driver assistance systems. Haptic steering guidance is an upcoming assistance system which facilitates lane-keeping performance while keeping drivers in the loop, and which may be particularly prone to BA. Thus far, experiments on haptic steering guidance have measured driver performance while the vehicle speed was kept constant. The aim of the present driving simulator study was to examine whether haptic steering guidance causes BA in the form of speeding, and to evaluate two types of haptic steering guidance designed not to suffer from BA...
November 16, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27863510/establishing-a-reference-array-for-the-cs-%C3%AE-%C3%AE-superfamily-of-defensive-peptides
#19
D Ellen K Tarr
BACKGROUND: "Invertebrate defensins" belong to the cysteine-stabilized alpha-beta (CS-αβ), also known as the scorpion toxin-like, superfamily. Some other peptides belonging to this superfamily of defensive peptides are indistinguishable from "defensins," but have been assigned other names, making it unclear what, if any, criteria must be met to qualify as an "invertebrate defensin." In addition, there are other groups of defensins in invertebrates and vertebrates that are considered to be evolutionarily unrelated to those in the CS-αβ superfamily...
November 18, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27844334/polymorphism-of-slc6a2-gene-does-not-influence-outcome-of-myocardial-123-i-mibg-scintigraphy-in-patients-with-chronic-heart-failure
#20
Derk O Verschure, F Baas, Berthe L F van Eck-Smit, G Aernout Somsen, Hein J Verberne
AIM: The NET, encoded by SLC6A2, is responsible for presynaptic NE-reuptake. (123)I-mIBG is clinically used to evaluate cardiac sympathetic function. However, it is unknown if polymorphism of SLC6A2 influences cardiac sympathetic activity as assessed with (123)I-mIBG. Therefore we studied the influence of SLC6A2 SNPs on myocardial (123)I-mIBG parameters in CHF. MATERIALS AND METHODS: Forty-nine adults with stable CHF (age 66.5 ± 8.1 years, LVEF 22.3 ± 6.4) were enrolled...
November 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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