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ALPPS procedure

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https://www.readbyqxmd.com/read/30213016/treatment-of-primary-hepatic-neuroendocrine-tumors-with-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-alpps-a-case-report-and-literature-review
#1
Chao Qu, Lin-Lin Qu, Cheng-Zhan Zhu, Zu-Sen Wang, Jingyu Cao
RATIONALE: Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare and are difficult to diagnose preoperatively.We report a case of PHNET diagnosed preoperatively and successfully resected using associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). PATIENT CONCERNS: A 72-year-old woman was admitted to our hospital for a hepatic mass, which was incidentally identified during a routine health checkup. The patient has no other obvious symptoms of discomfort...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30075551/associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-procedure-using-ischemic-bipartition-two-case-reports
#2
Marcel C C Machado, Emerson S Abe, Rodrigo Dumarco, Públio Viana, Marcel Autran C Machado
RATIONALE: The associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure is a recently introduced treatment strategy for patients with advanced primary or metastatic liver tumors and small future liver remnants. ALPPS procedure using ischemic bipartition of the liver is a modified technique that may reduce complications compared to classical ALPPS. PATIENT CONCERNS: Two patients with multiple colorectal liver metastasis with extensive involvement of the liver were considered unresectable before treatment because of small future liver remnant (FLR)...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30057123/preoperative-strategies-to-improve-resectability-for-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#3
REVIEW
Francisco Tustumi, Lucas Ernani, Fabricio F Coelho, Wanderley M Bernardo, Sérgio S Junior, Jaime A P Kruger, Gilton M Fonseca, Vagner B Jeismann, Ivan Cecconello, Paulo Herman
BACKGROUND: Preoperative strategies to increase the future liver remnant are useful methods to improve resectability rates for patients with hepatocellular carcinoma (HCC). The aim of this study was to perform a systematic review and meta-analysis of the main strategies used for this purpose. METHODS: A systematic review was performed in PubMed, EMBASE, Cochrane and Scielo/LILACS. The procedures included for analysis were portal vein embolization or ligation (PVE/PVL), sequential transarterial embolization and PVE (TACE + PVE), radioembolization (RE) and associated liver partition and portal vein ligation for staged hepatectomy (ALPPS)...
July 26, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29973758/first-ever-robotic-stage-one-alpps-procedure-in-india-for-colorectal-liver-metastases
#4
Jagadeesh Krishnamurthy, Adithya V Naragund, Basant Mahadevappa
Twenty five percent of total liver volume (TLV) is considered as the ideal functional liver remnant (FLR) in major liver resections. In patients with macro-vesicular steatosis, early cirrhosis, and post-neoadjuvant chemotherapy (NACT), hepatocellular injury is common. In such instances, up to 40% of FLR may be required. So in cases of marginal FLR, pre-operative portal vein (PV) embolization or two-stage hepatectomy with PV occlusion is used. Both of which take up to 14 weeks between stages and 30% of patients fail to reach the second resection either due to inadequate FLR growth or disease progression...
June 2018: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29881460/the-diagnostic-value-of-99m-tc-gsa-scintigraphy-for-liver-function-and-remnant-liver-volume-in-hepatic-surgery-a-retrospective-observational-cohort-study-in-27-patients
#5
Naokazu Chiba, Kei Yokozuka, Shigeto Ochiai, Takahiro Gunji, Masaaki Okihara, Toru Sano, Koichi Tomita, Rina Tsutsui, Shigeyuki Kawachi
Background: The aim was to analyze hepatic hypertrophy after portal vein embolization (PVE) and Associating Liver Partition with Portal vein ligation for Staged hepatectomy (ALPPS) to determine whether clinical circumstances associated with major hepatic resections correlated with remnant growth. Methods: Data was abstracted from a retrospectively maintained database on 27 patients undergoing hepatic resection followed by PVE and the ALPPS procedure between October 1, 2007 and December 31, 2016...
2018: Patient Safety in Surgery
https://www.readbyqxmd.com/read/29803563/indicating-alpps-for-colorectal-liver-metastases-a-critical-analysis-of-patients-in-the-international-alpps-registry
#6
Andreas A Schnitzbauer, Erik Schadde, Michael Linecker, Marcel A Machado, Rene Adam, Massimo Malago, Pierre A Clavien, Eduardo de Santibanes, Wolf O Bechstein
OBJECTIVES: In the international associating liver partition and portal vein ligation for staged hepatectomy registry, more than 50% of patients underwent associating liver partition and portal vein ligation for staged hepatectomy with a right hepatectomy. This study evaluated the necessity of two-stage hepatectomies being performed as right hepatectomy associating liver partition and portal vein ligation for staged hepatectomy in patients with colorectal liver metastases versus right trisectionectomy associating liver partition and portal vein ligation for staged hepatectomy...
September 2018: Surgery
https://www.readbyqxmd.com/read/29744337/monosegment-alpps-hepatectomy-preserving-segment-4-for-colorectal-liver-metastases-literature-review-and-our-experience
#7
Fiammetta Soggiu, Francesco Giovinazzo, Jack Straiton, Giulia Turri, Jim Phillips, Bassam Al-Kari, Irfan Ahmed, Mohammad Habib
Monosegment 4±1 Associating Liver Partition and Portal Vein ligation for Staged hepatectomy (ALPPS) for bilateral colorectal liver metastases decreases the risk of drop-out of two stage hepatectomy, triggering a rapid and significant increase in future liver remnant (FLR) with promising oncological outcomes. We report two cases of segment 4+1 monosegment ALPPS for multiple colorectal liver metastases performed at our institution. In the literature, seven similar cases have been reported. Short and long term outcomes of our two patients were reported along with a review of data from the literature...
April 2018: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29744336/laparoscopic-liver-resection-the-current-status-and-the-future
#8
REVIEW
Xiujun Cai
Dramatic progresses had been made in the operation in the past 26 years. Procedure was extended to major liver resection, isolated resection of caudate lobe, living donor liver resection and associating liver partition with portal vein ligation for staged hepatectomy (ALPPS). Laparoscopic liver resection became a new group of HPB surgery and the international laparoscopic liver society was established in Paris followed by the first international congress of the society held in Paris in July 2017. This biannual congress would be top convention for surgeons specialized in laparoscopic liver surgery...
April 2018: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29729926/fast-track-two-stage-hepatectomy-using-a-hybrid-interventional-radiology-operating-suite-as-alternative-option-to-associated-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-procedure
#9
Bruno C Odisio, Eve Simoneau, Alex A Holmes, Claudius H Conrad, Jean-Nicolas Vauthey
No abstract text is available yet for this article.
August 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29727331/10th-anniversary-of-alpps-lessons-learned-and-quo-vadis
#10
Hauke Lang, Eduardo de Santibañes, Hans J Schlitt, Massimo Malagó, Thomas van Gulik, Marcel A Machado, Elio Jovine, Stefan Heinrich, Giuseppe Maria Ettorre, Albert Chan, Roberto Hernandez-Alejandro, Ricardo Robles Campos, Per Sandström, Michael Linecker, Pierre-Alain Clavien
OBJECTIVE: Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has been tested in various indications and clinical scenarios, leading to steady improvements in safety. This report presents the current status of ALPPS. SUMMARY BACKGROUND DATA: ALPPS offers improved resectability, but drawbacks are regularly pointed out regarding safety and oncologic benefits. METHODS: During the 12th biennial congress of the European African-Hepato-Pancreato-Biliary Association (Mainz, Germany, May 23-26, 2017) an expert meeting "10th anniversary of ALPP" was held to discuss indications, management, mechanisms of regeneration, as well as pitfalls of this novel technique...
May 1, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29719286/serial-assessment-of-growth-factors-associated-with-liver-regeneration-in-patients-operated-with-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy
#11
Ernesto Sparrelid, Helene Johansson, Stefan Gilg, Greg Nowak, Ewa Ellis, Bengt Isaksson
BACKGROUND: There is limited knowledge about the mechanisms behind the unparalleled growth of the future liver remnant (FLR) linked to associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). In this study, liver regenerative markers were examined in patients subjected to ALPPS. METHODS: Ten patients with colorectal liver metastases treated with neoadjuvant chemotherapy and ALPPS were included. Plasma was sampled at 6 time points and biopsies from both liver lobes were collected at both stages of ALPPS...
2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29698885/the-use-of-a-nhs-peg-coated-collagen-based-sealant-in-a-patient-undergoing-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-alpps
#12
Pim B Olthof, Fadi Rassam, Thomas M van Gulik
INTRODUCTION: ALPPS (Associating Liver Partition and Portal vein Ligation for Staged hepatectomy) is a new two-stage hepatectomy for patients in whom conventional treatment is not feasible due to insufficient future liver remnant (FLR). During stage one of ALPPS, accelerated growth of the FLR is induced by ligation of the portal vein and in situ split of the liver, which prevents interlobar collateral portal circulation and attributes to the accelerated hypertrophy response. This can present a risk for postoperative haemorrhage...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29616108/liver-regeneration-during-the-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-procedure-in-sus-scrofa-is-positively-modulated-by-stem-cells
#13
Martin Bartas, Jiri Červeň, Jan Oppelt, Matus Peteja, Petr Vávra, Pavel Zonča, Vaclav Procházka, Vaclav Brázda, Petr Pečinka
This present study investigated the impact of the application of stem cells to liver regeneration following the first stage of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). The experiment was conducted on a pig model (n=6, 3 that did not receive application of stem cells, 3 that received application stem cells). Collected samples of liver (day 0 and 9 following surgery) were subjected to complete transcriptome sequencing. In total, 39 differentially expressed genes were found in the group without the application of the stem cells (genes of unwanted processes such as fibrosis and inflammation)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29599836/acute-kidney-injury-following-the-first-stage-of-the-alpps-procedure-a-case-report
#14
Weijie Tao, Xiaoju Shi, Guangyi Wang
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel approach for performing liver resection, and the number of clinical applications of this technique has rapidly increased within recent years. ALPPS is important in patients who have insufficient residual liver volume and cannot undergo radical hepatic resection. The most common postoperative complications of ALPPS include biliary fistula and infection. To date, postoperative acute kidney injury following ALPPS has not been reported...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29571618/insight-on-alpps-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-mechanisms-activation-of-mtor-pathway
#15
Mario Uribe, Sebastián Uribe-Echevarría, Carlos Mandiola, María I Zapata, Francisco Riquelme, Pamela Romanque
BACKGROUND: ALPPS procedure has been introduced to increase the volume of future liver remnant. The mechanisms underlying the accelerated regeneration observed with ALPPS are unknown. It was hypothesized that AMPK/mTOR is activated as an integrating pathway for metabolic signals leading to proliferation and cell growth. Our aim was to analyze increase in liver volume, proliferation parameters and expression of AMPK/mTOR pathway-related molecules in patients undergoing ALPPS. METHODS: A single center prospective study of patients undergoing ALPPS was performed from 2013 to 2015...
August 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29563755/maturity-of-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-derived-liver-regeneration-in-a-rat-model
#16
Yi-Fan Tong, Ning Meng, Miao-Qin Chen, Han-Ning Ying, Ming Xu, Billy Lu, Jun-Jie Hong, Yi-Fan Wang, Xiu-Jun Cai
AIM: To establish a rat model for evaluating the maturity of liver regeneration derived from associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). METHODS: In the present study, ALPPS, partial hepatecotmy (PHx), and sham rat models were established initially, which were validated by significant increase of proliferative markers including Ki-67, proliferating cell nuclear antigen, and cyclin D1. In the setting of accelerated proliferation in volume at the second and fifth day after ALPPS, the characteristics of newborn hepatocytes, as well as specific markers of progenitor hepatic cell, were identified...
March 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29562418/-current-status-of-alpps-in-the-treatment-of-advanced-liver-cancer-with-insufficient-future-liver-remnant
#17
Y L Cao, W Li
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) which represented a new two-steps liver resection procedures has been considered a revolutionary innovation for liver surgery technique in recent 10 years, it was first discovered by Professor Lang in Germany in 2007.The first step of the classic surgical procedures for portal vein ligation and liver parenchyma, until the future liver remnant (FLR) increased to a sufficient remnant then resect the right three-leaf liver.With the development of ALPPS, the method of hepatic parenchyma separation and isolation materials have been modified, which improves the safety of operation...
April 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29460877/-associated-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-alpps-in-focal-liver-diseases-management
#18
S E Voskanyan, E S Chuchuyev, A I Artemiyev, D A Zabezhinsky, A N Bashkov, A S Zhurbin, V S Rudakov, S V Cholakyan
AIM: To determine ALPPS advisability in small future remnant liver. MATERIAL AND METHODS: 22 ALPPS procedures were performed at the Center for Surgery and Transplantology for the period from 2011 to 2016. Indications were both tumoral and non-tumoral unresectable liver diseases. Postoperative complications were classified according to Clavien-Dindo, ISGLS. RESULTS: According to CT-volumetry future remnant liver before the 1st stage of ALPPS was from 17 to 25%, before the 2nd stage - from 28 to 49%...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29398585/does-intraoperative-success-predict-outcome-in-the-treatment-of-urethral-sphincter-insufficiency-with-bulking-agent
#19
Niklas Pakkasjärvi, Seppo Taskinen
INTRODUCTION: Sphincter insufficiency is mostly associated with neurogenic and some structural abnormalities in the pediatric population. As a mini-invasive treatment, urethral bulking agents have been used to treat this problem. OBJECTIVE: The aim was to evaluate if technical success, defined as intraoperative increase in abdominal leak point pressure (ALPP), predicts the outcome of the treatment of sphincter insufficiency with urethral bulking agent. STUDY DESIGN: We reviewed all children treated first time with dextranomer/hyaluronic acid (Dx/HA) copolymer (Deflux) for urethral sphincter insufficiency and who intraoperatively had ALPPs measured during 2004-2014...
April 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29391928/associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-for-extensive-alveolar-echinococcosis-first-case-report-in-the-literature
#20
Sami Akbulut, Egemen Cicek, Mehmet Kolu, Tevfik Tolga Sahin, Sezai Yilmaz
Alveolar echinococcosis (AE) is a zoonotic disease that is caused by Echinococcus multilocularis that affects liver and a variety of organs and tissues. It differs from other echinococcal disease because it shows tumor like behavior in the affected organ and tissues. The treatment of choice is concomitant medical therapy and resection with negative margins. Nevertheless, resection with the intent of negative margins (R0) may lead to serious complications such as liver failure. In the present case report, we used Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) procedure, which was defined in 2012 by Schnitzbauer et al, in a 28-year-old male patient to avoid complications of major liver resection in order to treat alveolar echinococcosis...
January 27, 2018: World Journal of Gastrointestinal Surgery
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