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https://www.readbyqxmd.com/read/29327281/effect-of-early-natal-supplementation-of-paracetamol-on-attenuation-of-exotoxin-endotoxin-induced-pyrexia-and-precipitation-of-autistic-like-features-in-albino-rats
#1
Abdulaziz S Saeedan, Indu Singh, Mohd Nazam Ansari, Manjari Singh, Jitendra K Rawat, Uma Devi, Swetlana Gautam, Rajnish K Yadav, Gaurav Kaithwas
The present study was aimed to test the hypothesis that paracetamol (PCM) can precipitate autistic like features when used to counteract vaccine-induced fever using experimental rat pups. The pups were treated with measles mumps rubella (MMR) vaccine, diphtheria tetanus and pertussis (DPT) vaccines and lipopolysaccharide (LPS) with subsequent PCM treatment. The pups were evaluated for postnatal growth (weight gain, eye opening) and behavior alterations (swimming performance, olfactory discrimination, negative geotaxis, nociception, and locomotor activity) by performing battery of neurobehavioral test...
January 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29326823/lichen-planus-following-tetanus-diphtheria-acellular-pertussis-vaccination-a-case-report-and-review-of-the-literature
#2
Heather C Rosengard, Chikoti M Wheat, Matthew P Tilson, Jonathan D Cuda
Lichen planus is an inflammatory dermatosis with a prevalence of approximately 1%. Recent meta-analyses show that patients with hepatitis C virus have a 2.5- to 4.5-fold increased risk of developing lichen planus. Lichen planus has also followed vaccinations and has specifically been attributed to the hepatitis B vaccine, the influenza vaccine, and the tetanus-diphtheria-acellular pertussis vaccine. We describe a case of lichen planus in a hepatitis C virus-infected African American male occurring in temporal association with the administration of the tetanus-diphtheria-acellular pertussis vaccine...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29326519/tetanus-a-report-of-two-cases-and-review-of-literature-a-continuing-threat-to-the-elderly-in-japan
#3
Tsutomu Sugiura, Kazuhiko Yamamoto, Masatoshi Sato, Tadaaki Kirita
Tetanus has become rare in industrialized countries, largely due to the effectiveness of immunization. However, the elderly are susceptible to tetanus because many have not received primary immunization; the incidence of tetanus in Japan is still 120 cases/year. The initial symptoms of tetanus, such as trismus and dysphagia, are observed in the orofacial region. However, because of the disease's rarity, the clinician may be unfamiliar with the clinical presentation and may not suspect tetanus. We report two cases of elderly patients with generalized tetanus...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29325822/parental-vaccine-hesitancy-in-italy-results-from-a-national-survey
#4
Cristina Giambi, Massimo Fabiani, Fortunato D'Ancona, Lorenza Ferrara, Daniel Fiacchini, Tolinda Gallo, Domenico Martinelli, Maria Grazia Pascucci, Rosa Prato, Antonietta Filia, Antonino Bella, Martina Del Manso, Caterina Rizzo, Maria Cristina Rota
In Italy, in 2016, we conducted a cross-sectional survey to estimate vaccine hesitancy and investigate its determinants among parents of children aged 16-36 months. Data on parental attitudes and beliefs about vaccinations were collected through a questionnaire administered online or self-administered at pediatricians' offices and nurseries. Parents were classified as pro-vaccine, vaccine-hesitant or anti-vaccine, according to self-reported tetanus and measles vaccination status of their child. Multivariable logistic regression was used to investigate factors associated with hesitancy...
January 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29325483/characterization-of-vaccination-policies-for-attendance-and-employment-at-day-summer-camps-in-new-york-state
#5
William A Prescott, Kelsey C Violanti, Nicholas M Fusco
INTRODUCTION: New York state requires day/summer camps to keep immunization records for all enrolled campers and strongly recommends requiring vaccination for all campers and staff. The objective of this study was to characterize immunization requirements/recommendations for children/adolescents enrolled in and staff employed at day/summer camps in New York state. METHODS: An electronic hyperlink to a 9-question survey instrument was distributed via e-mail to 178 day/summer camps located in New York state cities with a population size greater than 100 000 people...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29325171/maternal-and-child-health-handbook-use-for-maternal-and-child-care-a-cluster-randomized-controlled-study-in-rural-java-indonesia
#6
Keiko Osaki, Tomoko Hattori, Akemi Toda, Erna Mulati, Lukas Hermawan, Kirana Pritasari, Saptawati Bardosono, Soewarta Kosen
Background: Effectiveness of the Maternal and Child Health Handbook (MCHHB), a home-based booklet for pregnancy, delivery and postnatal/child health, was evaluated on care acquisition and home care in rural Java, a low service-coverage area. Methods: We conducted a health centre-based randomized trial, with a 2-year follow-up. Intervention included (i) MCHHB provision at antenatal care visits; (ii) records and guides by health personnel on and with the MCHHB; and (iii) sensitization of care by volunteers using the MCHHB...
January 9, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29324612/third-trimester-maternal-vaccination-against-pertussis-and-pertussis-antibody-concentrations
#7
Cynthia Abraham, Michael Pichichero, Jesse Eisenberg, Sonali Singh
OBJECTIVE: To compare pertussis antibody concentrations in maternal venous serum (at the time of delivery) and umbilical cord arterial serum among women vaccinated with the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine from either 27-30 6/7 weeks of gestation or from 31-35 6/7 weeks of gestation. METHODS: We conducted a prospective cohort study of pregnant women divided into two groups based on when Tdap was administered: 27-30 6/7 weeks of gestation and 31-35 6/7 weeks of gestation...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29317900/knowledge-attitudes-and-practices-related-to-tetanus-toxoid-vaccination-in-women-of-childbearing-age-a-cross-sectional-study-in-peri-urban-settlements-of-karachi-pakistan
#8
Yasir Shafiq, Asif Raza Khowaja, Mohammad Tahir Yousafzai, Syed Asad Ali, Anita Zaidi, Ali Faisal Saleem
Backgound: A higher incidence of neonatal tetanus implies failure of the vaccination program in Pakistan. Objectives: The objective of this study was to assess knowledge, attitudes and practices related to tetanus toxoid (TT) vaccine in women of childbearing age. Methods: We performed a cross-sectional survey in peri-urban Karachi, Pakistan, among women of childbearing age, stratified into three mutually exclusive groups as: married pregnant; married non-pregnant; and unmarried...
September 2017: Journal of Infection Prevention
https://www.readbyqxmd.com/read/29315536/a-decision-analytic-model-for-prevention-of-hepatitis-b-virus-infection-in-sub-saharan-africa-using-birth-dose-vaccination
#9
Sarah Anderson, Lorie M Harper, Jodie Dionne-Odom, Gregory Halle-Ekane, Alan T N Tita
OBJECTIVE: To compare prenatal maternal hepatitis B virus (HBV) screening and infant vaccination strategies to inform policy on HBV prevention in Sub-Saharan Africa. METHODS: A decision analytic model was created using previously published data to assess the ability of three intervention strategies to prevent HBV infection by age 10 years. Strategy 1 comprised of universal vaccination with a pentavalent vaccine (HBV, diphtheria, tetanus, pertussis, and Haemophilus influenzae) at age 6 weeks...
January 8, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29310705/intensity-of-contact-with-frontline-workers-and-its-influence-on-maternal-and-newborn-health-behaviors-cross-sectional-survey-in-rural-uttar-pradesh-india
#10
Tanica Lyngdoh, Sutapa B Neogi, Danish Ahmad, Srinivasan Soundararajan, Dileep Mavalankar
BACKGROUND: India is committed to improving maternal and newborn health in order to achieve the targets for India's Millennium Development Goal 4. Considering their role as a link between community and health systems, frontline workers (FLWs) can be effectively utilized in strengthening maternal and newborn care. In this paper, we set out to examine the effect of intensity of contact with FLWs on key maternal and newborn health behaviors and to determine if this association varies by status of Self Help Group (SHG) membership...
January 8, 2018: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29308916/maternal-immunization-where-are-we-now-and-how-to-move-forward
#11
Ivo Vojtek, Ilse Dieussaert, T Mark Doherty, Valentine Franck, Linda Hanssens, Jacqueline Miller, Rafik Bekkat-Berkani, Walid Kandeil, David Prado-Cohrs, Andrew Vyse
Pregnancy and the post-partum period are associated with elevated risks to both mother and infant from infectious disease. Vaccination of pregnant women, also called maternal immunization, has the potential to protect pregnant women, fetuses, and infants from several vaccine-preventable diseases. Maternal immunoglobulin G antibodies are actively transferred through the placenta to provide passive immunity to newborns during the first months of life, until the time for infant vaccinations or until the period of greatest susceptibility has passed...
January 8, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29306507/immunogenicity-and-safety-of-a-novel-tetanus-toxoid-conjugated-anti-gastrin-vaccine-in-balb-c-mice
#12
Qing He, Hua Gao, Meng Gao, Shengmei Qi, Kun Yang, Yingqi Zhang, Junzhi Wang
The objective of this study is to determine the immunogenicity and safety of our novel anti-gastrin vaccine that is composed of the common amino-terminal portions of human carboxy-amidated gastrin-17 (G17) and glycine-extended gastrin-17 (gly-G17) as well as the common carboxy-terminal portion of the gastrin precursor progastrin (in a 50:50 mixture) all covalently linked to tetanus toxoid (TT) via peptide spacers. The vaccine, or immunogen, was injected intramuscularly into the legs of BALB/c mice, which produced high serum titres of specific IgG antibodies and IFN-γ in their spleen cells, identifiable by enzyme-linked immunosorbent assay (ELISA) and enzyme-linked immunospot assay (ELISPOT), respectively...
January 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29306505/igg-antibody-prevalence-suggests-high-immunization-needs-in-newcomers-to-luxembourg-2012
#13
Judith M Hübschen, Emilie Charpentier, Pierre Weicherding, Claude P Muller
Vaccine coverage of the general population in Luxembourg is high, but refugees or asylum seekers may be incompletely vaccinated and susceptible to vaccine-preventable diseases. In order to assess protection rates, serum and oral fluid samples were collected from 406 newcomers aged between 13 and 70 years arriving between May and September 2012. Sera were screened for IgG antibodies against measles, rubella, mumps, hepatitis B, tetanus, diphtheria and pertussis. Oral fluid samples were screened for antibodies against measles, mumps and rubella virus to investigate their suitability for antibody prevalence studies...
January 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29304489/clinical-features-and-outcomes-of-tetanus-analysis-using-a-national-inpatient-database-in-japan
#14
Mikio Nakajima, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
PURPOSE: This study was performed to elucidate the current clinical features and outcomes of tetanus using a national inpatient database in Japan. MATERIALS AND METHODS: We used the Japanese Diagnosis Procedure Combination inpatient database to retrospectively investigate patients with tetanus from July 2010 to March 2016. We examined the patients' characteristics; the proportions of patients requiring tracheal intubation, mechanical ventilation, and tracheostomy; and the discharge status...
December 29, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29288818/re-vaccination-following-autologous-hematopoietic-stem-cell-transplantation-is-safe-and-effective-in-patients-with-multiple-myeloma-receiving-lenalidomide-maintenance
#15
Meighan Palazzo, Gunjan L Shah, Olivia Copelan, Kenneth Seier, Sean M Devlin, Molly Maloy, Sheila Kenny, Hani Hassoun, Neha S Korde, Nikoletta Lendvai, Alexander M Lesokhin, Sham Mailankody, David J Chung, Guenther Koehne, C Ola Landgren, Heather Landau, Sergio A Giralt, Miguel-Angel Perales
Guidelines recommend vaccination starting 12 months after autologous hematopoietic stem cell transplant (aHCT), but there is varying practice for patients on maintenance therapy, with some centers not immunizing at all. Due to decreased vaccine rates among the general population causing loss of herd immunity, we aimed to establish the safety and efficacy of revaccinating multiple myeloma patients on lenalidomide maintenance (LM). Of the 122 patients who were vaccinated after aHCT between 2010-2014 at MSKCC, 91 (75%) were on LM...
December 27, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29287062/the-influence-of-conjugation-variables-on-the-design-and-immunogenicity-of-a-glycoconjugate-vaccine-against-salmonella-typhi
#16
M Arcuri, R Di Benedetto, A F Cunningham, A Saul, C A MacLennan, F Micoli
In recent years there have been major efforts to develop glycoconjugate vaccines based on the Vi polysaccharide that will protect against Salmonella enterica Typhi infections, particularly typhoid fever, which remains a major public health concern in low-income countries. The design of glycoconjugate vaccines influences the immune responses they elicit. Here we systematically test the response in mice to Vi glycoconjugates that differ in Vi chain length (full-length and fragmented), carrier protein, conjugation chemistry, saccharide to protein ratio and size...
2017: PloS One
https://www.readbyqxmd.com/read/29285631/factors-associated-with-vaccination-status-of-children-aged-12-48-months-in-india-2012-2013
#17
Luke M Shenton, Abram L Wagner, Deepti Bettampadi, Nina B Masters, Bradley F Carlson, Matthew L Boulton
Objectives India has more unvaccinated children than any other country despite provision of free vaccines through the government's Universal Immunization Program. In this study, we calculated the proportion of children aged 12-48 months who were fully vaccinated, under-vaccinated, or who had not received any vaccines. Childhood, household, and sociocultural factors associated with under-vaccination and non-vaccination were evaluated. Methods Using data from India's 4th District-level Health and Facility Survey, 2012-2013 (DLHS-4) and the 2012-2013 Annual Health Survey (AHS), we calculated the proportion of children who were non-vaccinated, under-vaccinated, or fully vaccinated with 1 dose of Bacillus Calmette-Guérin, 3 doses of oral polio vaccine, 3 doses of diphtheria-pertussis-tetanus, and 1 dose of measles-containing vaccine...
December 28, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29276607/ventilator-associated-respiratory-infection-in-a-resource-restricted-setting-impact-and-etiology
#18
Vu Dinh Phu, Behzad Nadjm, Nguyen Hoang Anh Duy, Dao Xuan Co, Nguyen Thi Hoang Mai, Dao Tuyet Trinh, James Campbell, Dong Phu Khiem, Tran Ngoc Quang, Huynh Thi Loan, Ha Son Binh, Quynh-Dao Dinh, Duong Bich Thuy, Huong Nguyen Phu Lan, Nguyen Hong Ha, Ana Bonell, Mattias Larsson, Hoang Minh Hoan, Đang Quoc Tuan, Hakan Hanberger, Hoang Nguyen Van Minh, Lam Minh Yen, Nguyen Van Hao, Nguyen Gia Binh, Nguyen Van Vinh Chau, Nguyen Van Kinh, Guy E Thwaites, Heiman F Wertheim, H Rogier van Doorn, C Louise Thwaites
Background: Ventilator-associated respiratory infection (VARI) is a significant problem in resource-restricted intensive care units (ICUs), but differences in casemix and etiology means VARI in resource-restricted ICUs may be different from that found in resource-rich units. Data from these settings are vital to plan preventative interventions and assess their cost-effectiveness, but few are available. Methods: We conducted a prospective observational study in four Vietnamese ICUs to assess the incidence and impact of VARI...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/29258749/a-simple-method-for-measuring-immune-complex-mediated-fc-gamma-receptor-dependent-antigen-specific-activation-of-primary-human-t-cells
#19
Junker Fabian, Krishnarajah Sinduya, Qureshi Omar, Humphreys David, Fallah-Arani Farnaz
Immune complex (IC) deposition of IgG containing autologous antigens has been observed in autoimmunity. This can lead to IC-mediated antigen uptake and presentation by antigen presenting cells (APC) driving T cell dependent inflammation. IgG receptors (FcγRs) have been suggested to be involved in this process. Since ICs have been linked to autoimmune diseases, interfering with IC mediated effects on APCs and subsequent autoimmune T cell activation via FcγR blockade may be therapeutically beneficial. However, this is currently challenging due to a lack of translatable animal models and specific human in vitro assays to study IC-driven T cell responses...
December 16, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29249542/conventional-influenza-vaccines-influence-the-performance-of-a-universal-influenza-vaccine-in-mice
#20
Janelle Rowell, Chia-Yun Lo, Graeme E Price, Julia A Misplon, Suzanne L Epstein, Mayra Garcia
Universal influenza vaccines are designed to protect against diverse strains of influenza virus. Preclinical testing of new vaccine candidates is usually done in naïve animals, despite intended use in the human population with its varied immune history including responses to previous vaccinations. As an approach more relevant to human use, we tested a candidate universal influenza vaccine in mice with a history of conventional vaccination. Female BALB/c mice were given two intramuscular doses of inactivated influenza vaccine (IIV) or diphtheria and tetanus toxoids vaccine (DT), one month apart...
December 14, 2017: Vaccine
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