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https://www.readbyqxmd.com/read/27930568/does-vaccination-ensure-protection-assessing-diphtheria-and-tetanus-antibody-levels-in-a-population-of-healthy-children-a-cross-sectional-study
#1
Ewelina Gowin, Jacek Wysocki, Ewelina Kałużna, Bogna Świątek-Kościelna, Joanna Wysocka-Leszczyńska, Michał Michalak, Danuta Januszkiewicz-Lewandowska
Vaccination effectiveness is proven when the disease does not develop after a patient is exposed to the pathogen. In the case of rare diseases, vaccination effectiveness is assessed by monitoring specific antibody levels in the population. Such recurrent analyses allow the evaluation of vaccination programs. The primary schedule of diphtheria and tetanus vaccinations is similar in various countries, with differences mainly in the number and timing of booster doses. The aim of the study was to assess diphtheria and tetanus antibody concentrations in a population of healthy children...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929751/recommended-vaccinations-for-asplenic-and-hyposplenic-adult-patients
#2
Paolo Bonanni, Maddalena Grazzini, Giuditta Niccolai, Diana Paolini, Ornella Varone, Alessandro Bartoloni, Bartalesi Filippo, Maria Grazia Santini, Simonetta Baretti, Carlo Bonito, Paola Zini, Mechi Maria Teresa, Niccolini Fabrizio, Magistri Lea, Pulci Maria Beatrice, Sara Boccalini, Angela Bechini
Asplenic or hyposplenic (AH) individuals are particularly vulnerable to invasive infections caused by encapsulated bacteria. Such infections have often a sudden onset and a fulminant course. Infectious diseases (IDs) incidence in AH subjects can be reduced by preventive measures such as vaccination. The aim of our work is to provide updated recommendations on prevention of infectious diseases in AH adult patients, and to supply a useful and practical tool to healthcare workers for the management of these subjects, in hospital setting and in outpatients consultation...
December 8, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27929748/evaluation-of-inflammatory-and-immune-responses-in-long-term-cultured-human-precision-cut-lung-slices
#3
Angela Temann, Tatiana Golovina, Vanessa Neuhaus, Carolann Thompson, Jessica A Chichester, Armin Braun, Vidadi Yusibov
The development of systems that are more accurate and time-efficient in predicting safety and efficacy of target products in humans are critically important in reducing the cost and duration of pharmaceutical development. To circumvent some of the limitations imposed by the use of animal models, ex vivo systems, such as precision-cut lung slices (PCLS), have been proposed as an alternative for evaluating safety, immunogenicity and efficacy of vaccines and pharmaceuticals. In this study, we have established a human PCLS system and methodology for PCLS cultivation that can provide long-term viability and functionality in culture...
December 8, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27927258/a-case-of-tetanus-secondary-to-an-odontogenic-infection
#4
Majid Darraj, James Stone, Yoav Keynan, Kristjan Thompson, Carolyn Snider
Tetanus is a life-threatening clinical syndrome that commonly presents with muscular spasms, rigidity, and autonomic instability. It is considered rare in industrialized countries, and tetanus occurring secondary to dental abscesses, procedures, or infections has been infrequently reported. We describe the case of a patient inadequately immunized for tetanus, who presented to the emergency department with muscular spasms, rigidity, and autonomic instability in the setting of an odontogenic infection. A clinical diagnosis of tetanus was made and subsequently managed successfully...
December 8, 2016: CJEM
https://www.readbyqxmd.com/read/27927058/immunoadjuvant-potential-of-cross-linked-dextran-microspheres-mixed-with-chitosan-nanospheres-encapsulated-with-tetanus-toxoid
#5
Haniyeh Pirouzmand, Bahman Khameneh, Mohsen Tafaghodi
CONTEXT: Nasal mucosa is a desirable route for mucosal vaccine delivery. Mucosal co-administration of chitosan nanoparticles with absorption enhancers such as cross-linked dextran microspheres (CDM, Sephadex(®)) is a promising antigen delivery system. OBJECTIVE: In the current study, the chitosan nanospheres loaded with tetanus toxoid (CHT:TT NPs) was prepared and characterized. The immune responses against tetanus toxoid after nasal administration of CHT:TT NPs alone or mixed with CDM were also determined...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27926921/schistosoma-mansoni-infection-can-jeopardize-the-duration-of-protective-levels-of-antibody-responses-to-immunizations-against-hepatitis-b-and-tetanus-toxoid
#6
Diana K Riner, Eric M Ndombi, Jennifer M Carter, Amos Omondi, Nupur Kittur, Emmy Kavere, Harrison K Korir, Briana Flaherty, Diana Karanja, Daniel G Colley
BACKGROUND: Schistosomiasis is a disease of major public health importance in sub-Saharan Africa. Immunoregulation begins early in schistosome infection and is characterized by hyporesponsiveness to parasite and bystander antigens, suggesting that a schistosome infection at the time of immunization could negatively impact the induction of protective vaccine responses. This study examined whether having a Schistosoma mansoni infection at the time of immunization with hepatitis B and tetanus toxoid (TT) vaccines impacts an individual's ability to achieve and maintain protective antibody levels against hepatitis B surface antigen or TT...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27921176/two-feet-on-the-membrane-uptake-of-clostridial-neurotoxins
#7
Andreas Rummel
The extraordinary potency of botulinum neurotoxins (BoNT) and tetanus neurotoxin (TeNT) is mediated by their high neurospecificity, targeting peripheral cholinergic motoneurons leading to flaccid and spastic paralysis, respectively, and successive respiratory failure. Complex polysialo gangliosides accumulate BoNT and TeNT on the plasma membrane. The ganglioside binding in BoNT/A, B, E, F, G, and TeNT occurs via a conserved ganglioside-binding pocket within the most carboxyl-terminal 25 kDa domain HCC, whereas BoNT/C, DC, and D display here two different ganglioside binding sites...
December 1, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/27920395/tetanus-immunity-gaps-in-children-5-14-years-and-men-%C3%A2-15-years-of-age-revealed-by-integrated-disease-serosurveillance-in-kenya-tanzania-and-mozambique
#8
Heather M Scobie, Minal Patel, Diana Martin, Harran Mkocha, Sammy M Njenga, Maurice R Odiere, Sonia Pelletreau, Jeffrey W Priest, Ricardo Thompson, Kimberly Y Won, Patrick J Lammie
Recent tetanus cases associated with male circumcision in Eastern and Southern Africa (ESA) prompted an examination of tetanus immunity by age and sex using multiplex serologic data from community surveys in three ESA countries during 2012-2013. Tetanus seroprotection was lower among children 5-14 years versus 1-4 years of age in Kenya (66% versus 90%) and Tanzania (66% versus 89%), but not in Mozambique (91% versus 88%), where children receive two booster doses in school. Among males ≥ 15 years of age, tetanus seroprotection was lower than females in Kenya (45% versus 96%), Tanzania (28% versus 94%), and Mozambique (64% versus 90%)...
December 5, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27917962/human-and-animal-health-surveys-among-pastoralists
#9
E Schelling, H Greter, H Kessely, M F Abakar, B N Ngandolo, L Crump, B Bold, J Kasymbekov, Z Baljinnyam, G Fokou, J Zinsstag, B Bonfoh, J Hattendorf, M Béchir
Valid human and livestock health surveys, including longitudinal follow-up, are feasible among mobile pastoralists and provide fundamental information to agencies for interventions that are responsive to realities and effective in addressing the needs of pastoralists. However, pastoralists are often excluded from studies, surveillance systems and health programmes. The occurrence of preventable and treatable diseases such as perinatal tetanus, measles and tuberculosis are indicative of limited access to health providers and information...
November 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/27917091/vaccinating-patients-with-inflammatory-bowel-disease
#10
Jason Reich, Sharmeel Wasan, Francis A Farraye
Patients with inflammatory bowel disease (IBD) are not vaccinated at the same rate as general medical patients. IBD places patients at increased risk for developing vaccine-preventable illnesses, and this risk is further exacerbated by immunosuppressive therapy. Therefore, gastroenterologists should familiarize themselves with health maintenance measures pertaining to patients with IBD. This article highlights the vaccinations required for patients with IBD, especially those who are immunosuppressed: influenza; pneumococcal pneumonia; hepatitis A and B viruses; human papilloma virus; meningococcal disease; tetanus, diphtheria, and pertussis; measles, mumps, and rubella; varicella zoster; and herpes zoster...
September 2016: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27916543/rapid-assessment-of-tetanus-vaccine-induced-immunity-in-bangladesh-and-the-gambia
#11
Girija Ramakrishnan, Marcia Wright, Masud Alam, Caitlin Naylor, Mamun Kabir, Ayesha Zerin, Tahsin Ferdous, Karl Pedersen, Branwen J Hennig, Jeffrey R Donowitz, Rita Wegmuller, Rashidul Haque, William A Petri, Joel Herbein, Carol A Gilchrist
We have developed recombinant fragment C based rapid point of care dipstick devices to assess tetanus immunization status using plasma or whole blood. The devices demonstrated specificity of 0.90 and sensitivity of 0.90 (whole blood)/0.94 (plasma) at field sites in Bangladesh and The Gambia when compared to a commercial ELISA with the immune cut-off titer set as ≥0.1IU/mL.
November 24, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27905982/the-use-of-a-lot-quality-assurance-sampling-methodology-to-assess-and-manage-primary-health-interventions-in-conflict-affected-west-darfur-sudan
#12
Kiemanh Pham, Emily Chambers Sharpe, William M Weiss, Alexander Vu
BACKGROUND: Organizations working in conflict-affected areas have a need to monitor and evaluate their programs, however this is often difficult due to the logistical challenges of conflict areas. Lot quality assurance sampling may be a suitable method of assessing programs in these situations. METHODS: We conducted a secondary data analysis of information collected during Medair's routine program management functions. Medair's service area in West Darfur, Sudan was divided into seven supervisory areas...
October 6, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27904622/successful-elimination-of-maternal-and-neonatal-tetanus-in-india-ray-of-hope-for-other-nations
#13
Saurabh R Shrivastava, Prateek S Shrivastava, Jegadeesh Ramasamy
No abstract text is available yet for this article.
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27902906/generalized-tetanus-in-a-gyrfalcon-falco-rusticolus-with-pododermatitis
#14
Hugues Beaufrère, Delphine Laniesse, Paul Stickings, Robert Tierney, Thea Sesardic, Durda Slavic, Nicole Compo, Dale A Smith
A 2-yr-old male gyrfalcon ( Falco rusticolus ) was presented for severe and generalized muscle spasticity and pododermatitis. The falcon had been treated for pododermatitis over the previous 4 mo. Muscle rigidity and spasms involved the entire bird but were more severe on the right leg. The bird was also tachypneic and hyperthermic at 45 C. While the plantar pododermatitis lesions had healed, there was still a small abscess on the lateral aspect of the right foot. Clinical signs were consistent with tetanus...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27891698/vaccination-and-unexplained-sudden-death-risk-in-taiwanese-infants
#15
Wan-Ting Huang, Robert T Chen, Yu-Chen Hsu, John W Glasser, Philip H Rhodes
PURPOSE: In March 1992, eight infants who had died within 36 hours of receiving whole-cell pertussis vaccine (diphtheria, tetanus, and whole-cell pertussis [DTwP]) prompted the Taiwan health authorities to suspend its use. We conducted an investigation of vaccination and sudden unexplained infant death (SUID) and repeated it more recently after Taiwan switched to acellular pertussis vaccine (diphtheria, tetanus, and acellular pertussis [DTaP]) in 2010. METHODS: All SUIDs aged 31-364 days during 1990-1992 and 1996-2013 were selected from the death registration databases...
November 28, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27891499/a-presumptive-case-of-human-rabies-a-rare-survived-case-in-rural-ghana
#16
Paschal Awingura Apanga, John Koku Awoonor-Williams, Michael Acheampong, Matthew Ayamba Adam
Rabies remains endemic in Ghana and continues to pose a major public health threat to humans and animals with a nearly 100% case fatality rate in humans. We report of a presumptive case of human rabies whose survival represents a rare occurrence in rural Ghana and worldwide. Lessons from this case study provide a critically needed focus in helping improve rabies surveillance and case management in Ghana. We report of the survival of a 36-year-old man who developed clinical rabies after he was bitten by his dog, while restraining the dog with a chain...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27889981/chimeric-trojan-protein-insertion-in-lentiviral-membranes-makes-lentiviruses-susceptible-to-neutralisation-by-anti-tetanus-serum-antibodies
#17
Anita Le-Heron, Steve Patterson, Rafael J Yáñez-Muñoz, George Dickson
This study describes the initial testing of a novel strategy for neutralisation of lentiviruses using the fundamental biology of enveloped viruses' assembly and budding. In the field of gene therapy, viral vector surface proteins have been manipulated in order to redirect host cell specificity by alteration of pseudo-types. We tested whether known viral pseudo-typing proteins or surface proteins known to be recruited to the HIV envelope could be engineered to carry neutralising epitopes from another microorganism onto the lentiviral surface...
November 27, 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27889711/immunogenicity-and-safety-of-a-liquid-hexavalent-vaccine-in-indian-infants
#18
Jugesh Chhatwal, Sanjay Lalwani, Emmanuel Vidor
OBJECTIVE: To evaluate the immunogenicity and safety of a fully liquid, hexavalent diphtheria tetanus acellular pertussis inactivated poliovirus hepatitis B Haemophilus influenzae type b (DTaP IPV HB PRPT) vaccine in Indian infants. DESIGN: Phase III, single-arm study. SETTING: Two tertiary care hospitals. PARTICIPANTS: 177 healthy, 6-week-old infants. INTERVENTION: All participants received HB and OPV vaccines at birth and DTaP-IPV-HB-PRP~T at 6, 10, 14 weeks of age...
November 5, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27881950/a-new-approach-of-modified-submerged-patch-clamp-recording-reveals-interneuronal-dynamics-during-epileptiform-oscillations
#19
Gareth Morris, Premysl Jiruska, John G R Jefferys, Andrew D Powell
Highlights Simultaneous epileptiform LFPs and single-cell activity can be recorded in the membrane chamber.Interneuron firing can be linked to epileptiform high frequency activity.Fast ripples, unique to chronic epilepsy, can be modeled in ex vivo tissue from TeNT-treated rats. Traditionally, visually-guided patch clamp in brain slices using submerged recording conditions has been required to characterize the activity of individual neurons. However, due to limited oxygen availability, submerged conditions truncate fast network oscillations including epileptiform activity...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27879555/safety-and-immunogenicity-of-dtap5-ipv-compared-with-dtap5-plus-ipv-as-the-fifth-dose-in-children-4-to-6-years-of-age
#20
Michael J Smith, Emilia Jordanov, Xiaohua Sheng, Peter H Tsang
BACKGROUND: Immunogenicity and safety of stand-alone diphtheria, tetanus toxoid, 5-component acellular pertussis vaccine adsorbed, inactivated poliovirus (IPV) combination vaccine (DTaP5-IPV) was compared with separate DTaP5 plus IPV vaccines as fifth dose in children 4-6 years of age. METHODS: In this phase III, controlled, multicenter, randomized, open-label study participants were randomized to DTaP5-IPV plus measles/mumps/rubella (MMR) and varicella virus (VZV) vaccines (Group 1; N=324), DTaP5+IPV with MMR and VZV (Group 2; N=327), DTaP5-IPV with/without MMR/VZV (Group 3; N=2419), or DTaP5+IPV with/without MMR/VZV (Group 4; N=302)...
November 22, 2016: Pediatric Infectious Disease Journal
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