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https://www.readbyqxmd.com/read/27905409/compound-danshen-dripping-pills-modulate-the-perturbed-energy-metabolism-in-a-rat-model-of-acute-myocardial-ischemia
#1
Jiahua Guo, Yonghong Yong, Jiye Aa, Bei Cao, Runbin Sun, Xiaoyi Yu, Jingqiu Huang, Na Yang, Lulu Yan, Xinxin Li, Jing Cao, Nan Aa, Zhijian Yang, Xiangqing Kong, Liansheng Wang, Xuanxuan Zhu, Xiaohui Ma, Zhixin Guo, Shuiping Zhou, He Sun, Guangji Wang
The continuous administration of compound danshen dripping pills (CDDP) showed good efficacy in relieving myocardial ischemia clinically. To probe the underlying mechanism, metabolic features were evaluated in a rat model of acute myocardial ischemia induced by isoproterenol (ISO) and administrated with CDDP using a metabolomics platform. Our data revealed that the ISO-induced animal model showed obvious myocardial injury, decreased energy production, and a marked change in metabolomic patterns in plasma and heart tissue...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27899757/drip-and-ship-versus-direct-to-comprehensive-stroke-center-conditional-probability-modeling
#2
Jessalyn K Holodinsky, Tyler S Williamson, Noreen Kamal, Dhruv Mayank, Michael D Hill, Mayank Goyal
No abstract text is available yet for this article.
November 29, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27889443/the-application-of-silicon-sol-gel-technology-to-forensic-blood-substitute-development-mimicking-aspects-of-whole-human-blood-rheology
#3
Theresa Stotesbury, Mike Illes, Paul Wilson, Andrew J Vreugdenhil
Solution-gelation chemistry has promising applications in forensic synthetic blood substitute development. This research offers a silicon-based sol-gel approach to creating stable materials that share similar rheological properties to that of whole human blood samples. Room temperature, high water content, silicon sol-gels were created using the organosilane precursors 3-glycidoxypropyltrimethoxysilane and tetraethylorthosilicate along with various concentrations of filler and pigment. Shear-thinning non-Newtonian properties were observed within most formulations of the presented materials...
November 15, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27881011/adjuvant-chemotherapy-with-bevacizumab-i-p-can-prolong-survival-time-of-patients-with-advanced-ovarian-cancer-after-cytoreduction
#4
F DU, P Li, J Chen, Z Gong, C Chi, B Hu, H Chu
Objective To assess whether adjuvant chemotherapy with bevacizumab intraperitoneal (i.p.) is better than adjuvant chemotherapy with bevacizumab intravenous (i.v.) or adjuvant chemotherapy only for patients with advanced ovarian cancer after cytoreduction. Selected patients with advanced ovarian cancer after cytoreduction were divided into three groups depend on their will: adjuvant chemotherapy only; adjuvant chemotherapy combined with bevacizumab intravenous (i.v.); adjuvant chemotherapy combined with bevacizumab intraperitoneal (i...
November 24, 2016: Neoplasma
https://www.readbyqxmd.com/read/27875061/glycemic-control-reduces-infections-in-post-liver-transplant-patients-results-of-a-prospective-randomized-study
#5
Amisha Wallia, Kathleen Schmidt, Diana Johnson Oakes, Teresa Pollack, Nicholas Welsh, Susan Kling-Colson, Suruchi Gupta, Candice Fulkerson, Grazia Aleppo, Neehar Parikh, Josh Levitsky, J P Norvell, Alfred Rademaker, Mark E Molitch
CONTEXT: Prior studies have shown a relationship between glycemic control and post-transplant morbidity. OBJECTIVE: We conducted a prospective randomized controlled trial in post liver transplant patients, evaluating intensive inpatient glycemic control and effects on outcomes to 1 year. Research Design and Intervention: 164 patients (blood glucose (BG) > 180 mg/dL) were randomized to two target groups: BG 140 mg/dL (N= 82) and 180 mg/dL (N= 82). Patients were initiated on insulin drips and then converted to subcutaneous basal bolus insulin therapy by our Glucose Management Service...
November 22, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27874180/passive-drip-stain-formation-dynamics-of-blood-onto-hard-surfaces-and-comparison-with-simple-fluids-for-blood-substitute-development-and-assessment
#6
Theresa Stotesbury, Michael C Taylor, Mark C Jermy
The spreading dynamics of blood dripping onto hard surfaces is compared to two spreading models. Samples of human blood, porcine blood, and Millipore(®) water were dripped onto cardboard, foamcore, and glass surfaces in low velocity passive drip simulations. Final stain diameter, the total number of spines and scallops, and angle of impact were measured and analyzed. Spreading is best predicted by applying the concept of effective viscosity to the Scheller and Bousfield (R(2)  = 0.91) and Roisman (R(2)  = 0...
November 22, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27874054/combinational-immunotherapy-with-allo-dribble-vaccines-and-anti-ox40-co-stimulation-leads-to-generation-of-cross-reactive-effector-t-cells-and-tumor-regression
#7
Guangjie Yu, Yuhuan Li, Zhihua Cui, Nicholas P Morris, Andrew D Weinberg, Bernard A Fox, Walter J Urba, Lixin Wang, Hong-Ming Hu
It is well-known that vaccines comprising of irradiated whole tumor cells or tumor-derived heat shock proteins can generate tumor-specific immune responses. In contrast, we showed recently that vaccines composed of autophagosomes (DRibbles) derived from syngeneic sarcomas could induce cross-reactive T-cell responses and cross-protection against the tumor. This unusual property of DRibbles was related to the selective recruitment of defective ribosomal products (DRiPs) and other short-lived proteins (SLiPs) into autophagosomes via sequestosome (SQSTM1, p62) mediated association of ubiquitinated SLiPs to the autophagy gene product LC3...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27859922/cadexomer-iodine-provides-superior-efficacy-against-bacterial-wound-biofilms-in-vitro-and-in-vivo
#8
Daniel J Fitzgerald, Paul J Renick, Emma C Forrest, Shannon P Tetens, David N Earnest, Jillian McMillan, Brett M Kiedaisch, Lei Shi, Eric D Roche
Examination of clinical samples indicates bacterial biofilms are present in the majority of chronic wounds, and substantial evidence suggests biofilms contribute significantly to delayed healing. Bacteria in biofilms are highly tolerant of antimicrobials, and little data exist to guide the choice of anti-biofilm wound therapy. Cadexomer Iodine (CI) was recently reported to have superior efficacy compared to diverse wound dressings against Pseudomonas aeruginosa biofilms in an ex vivo model. In the current study, the strong performance of CI versus P...
November 17, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27857546/comparison-of-meat-quality-and-fatty-acid-composition-of-longissimus-muscles-from-purebred-pigs-and-three-way-crossbred-lyd-pigs
#9
Yeong-Seok Choi, Jin-Kyu Lee, Ji-Taek Jung, Young-Chul Jung, Jong-Hyun Jung, Myung-Ok Jung, Yang-Il Choi, Sang-Keun Jin, Jung-Seok Choi
This study was conducted to find pork quality to meet the needs of consumers. Thus, the meat quality and fatty acid composition of longissimus muscles from purebred pigs (Landrace, Yorkshire, and Duroc) and three-way crossbred LYD pigs were compared and evaluated. Chemical compositions of longissimus muscles were significant (p<0.05) different among pigs. Duroc contained significant (p<0.05) higher fat contents than other pigs, whereas significant (p<0.05) higher moisture contents were observed in Landrace, Yorkshire, and LYD pigs compared to those of Duroc pigs...
October 31, 2016: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/27857545/fatty-acid-profiles-of-ten-muscles-from-high-and-low-marbled-quality-grade-1-and-2-hanwoo-steers
#10
Young-Hwa Hwang, Seon-Tea Joo
The aim of this research was to evaluate: 1) the fatty acid profile of ten muscles from high marbled (HM, quality grade 1(++)) and low marbled (LM, quality grade 2) Hanwoo carcass, 2) the relationship between the fatty acid profile and sensory traits. There were significant (p<0.001) differences in fat content and fatty acid composition among the 10 muscles obtained from HM and LM Hanwoo steers. The proportions of SFA (saturated fatty acid), MUFA (monounsaturated fatty acid) and PUFA (polyunsaturated fatty acid) were significantly (p<0...
October 31, 2016: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/27857540/meat-quality-and-physicochemical-trait-assessments-of-berkshire-and-commercial-3-way-crossbred-pigs
#11
Sivakumar Allur Subramaniyan, Da Rae Kang, Shah Ahmed Belal, Eun-So-Ri Cho, Jong-Hyun Jung, Young-Chul Jung, Yang-Il Choi, Kwan-Seob Shim
In this study, we compared qualities and physiochemical traits of meat from Berkshire (black color) pigs with those of meat from 3-way Landrace (white color) × Yorkshire (white color) × Duroc (red color) crossbred pigs (LYD). Meat quality characteristics, including pH, color, drip loss, cooking loss, and free amino acid, fatty acid, vitamin, and mineral contents of longissimus dorsi muscles, were compared. Meat from Berkshire pigs had deeper meat color (redness), higher pH, and lower drip loss and cooking loss than meat from LYD pigs...
October 31, 2016: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/27857533/effects-of-morphological-characteristics-of-muscle-fibers-on-porcine-growth-performance-and-pork-quality
#12
Sang Hoon Lee, Jun-Mo Kim, Youn Chul Ryu, Kwang Suk Ko
The aim of this study was to investigate the effects of morphological characteristics of porcine muscle fibers on growth performance, muscle fiber characteristics, and pork quality taken from the longissimus dorsi muscle. A total of 239 crossbred pigs (164 castrated males and 75 females) were used in this study. Experimental pigs were categorized by the total number of muscle fiber (TNF: High and Low) and cross sectional area of muscle fiber (CSAF: Large, Middle, and Small). Their combinations were classified into six groups (High-Large, HL; High-Middle, HM; High-Small, HS; Low-Large, LL; Low-Middle, LM; Low-Small, LS)...
October 31, 2016: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/27854153/genetic-factors-affecting-pork-quality-halothane-and-rendement-napole-genes
#13
Ramon Cesar D Salas, Claro N Mingala
The most common pork quality problems are pale, soft, and exudative (PSE) and acid pork (AP). PSE is associated with the expression of recessive halothane (Hal) allele Hal(n). Recessive Hal pigs (Hal(nn)) have defective Ca(2+) release channels (CRC) or Ryanodine Receptors (RYR1) within the sarcoplasmic reticulum that allow uncontrolled release of Ca(2+) in response to stress. Abnormal lactic acid metabolism caused by stress prior to slaughter leads to the sudden drop in postmortem muscle pH producing the PSE pork...
November 17, 2016: Animal Biotechnology
https://www.readbyqxmd.com/read/27854128/production-traits-of-artificially-and-naturally-hatched-geese-in-%C3%A4-ntensive-and-free-range-systems-ii-slaughter-carcass-and-meat-quality-traits
#14
M A Boz, M Sarica, U S Yamak
1. This study investigated the slaughter, carcass and meat-quality traits of artificially and naturally hatched geese in intensive and free-range production systems. 2. The study was conducted with 114 naturally hatched and 102 artificially hatched geese. From each replicate of the intensive and free-range systems, 1 female and 1 male goose were slaughtered at the ages of 14, 16 and 18 weeks (a total of 32 geese per slaughter week). 3. Artificially hatched geese had higher slaughter weights (5280 vs 4404 g), carcass weights (3520 vs 2863), dressing percentages (66...
November 17, 2016: British Poultry Science
https://www.readbyqxmd.com/read/27850508/870-continuous-drip-versus-intermittent-bolus-sedation-for-pediatric-procedural-sedation
#15
Apurva Panchal, Bala Bhaskar Reddy Bhimavarapu
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27845563/effects-of-dietary-supplementation-with-carnosine-on-meat-quality-and-antioxidant-capacity-in-broiler-chickens
#16
J Cong, L Zhang, J Li, S Wang, F Gao, G Zhou
1. This study aimed to investigate the effects of carnosine supplementation on meat quality, antioxidant capacity and lipid peroxidation status in broiler chickens. 2. A total of 256 1-d-old male Arbor Acres broilers were randomly assigned to 4 treatments consisting of 8 replicates of 8 chickens each. The birds were supplied with 4 different diets: a basal diet or a basal diet supplemented with 100, 200 or 400 mg/kg carnosine, respectively. The whole experiment lasted 42 d. 3. The results showed that dietary supplementation with carnosine linearly increased the values of pH45min and redness, and reduced drip loss of breast meat...
November 15, 2016: British Poultry Science
https://www.readbyqxmd.com/read/27837164/evaluation-of-a-pharmacy-managed-heparin-protocol-for-extracorporeal-membrane-oxygenation-patients
#17
Kalliopi Fitousis, Robin Klasek, Phillip E Mason, Faisal Masud
INTRODUCTION: Unfractionated heparin is the preferred anticoagulant in extracorporeal membrane oxygenation (ECMO) patients. However, there is a lack of consensus on its titration and monitoring. The objective of this study was to describe the efficacy and safety of a pharmacy managed heparin protocol utilizing activated partial thromboplastin time (aPTT) in comparison to our standard physician-managed activated clotting time (ACT)-based anticoagulation in ECMO patients. METHODS: Patients administered a heparin drip while on ECMO were included in the study...
November 10, 2016: Perfusion
https://www.readbyqxmd.com/read/27837118/effects-of-dietary-organic-zinc-and-%C3%AE-tocopheryl-acetate-supplements-on-growth-performance-meat-quality-tissues-minerals-and-%C3%AE-tocopherol-deposition-in-broiler-chickens
#18
R Akbari Moghaddam Kakhki, R Bakhshalinejad, A Hassanabadi, P Ferket
The aim of this study was to evaluate the effects of different dietary levels of zinc (Zn) and α-tocopheryl acetate (α-TOA) on broilers performance, meat quality, Zn, selenium (Se), and α-tocopherol (α-TO) tissue depositions. A total of 1,080 one-day-old Ross 308 broiler chickens (mixed-sex) were allocated to nine dietary treatments. Three levels of supplemental Zn (0, 60, and 120 mg/kg of diet) and three levels of α-TOA (0, 150, and 300 mg/kg of diet) were combined as a completely randomized design with 3 × 3 factorial arrangement...
November 11, 2016: Poultry Science
https://www.readbyqxmd.com/read/27833113/elucidating-a-molecular-mechanism-that-the-deterioration-of-porcine-meat-quality-responds-to-increased-cortisol-based-on-transcriptome-sequencing
#19
Xuebin Wan, Dan Wang, Qi Xiong, Hong Xiang, Huanan Li, Hongshuai Wang, Zezhang Liu, Hongdan Niu, Jian Peng, Siwen Jiang, Jin Chai
Stress response is tightly linked to meat quality. The current understanding of the intrinsic mechanism of meat deterioration under stress is limited. Here, male piglets were randomly assigned to cortisol and control groups. Our results showed that when serum cortisol level was significantly increased, the meat color at 1 h postmortem, muscle bundle ratio, apoptosis rate, and gene expression levels of calcium channel and cell apoptosis including SERCA1, IP3R1, BAX, Bcl-2, and Caspase-3, were notably increased...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27821223/effect-of-substitution-of-oat-hulls-for-traditional-fiber-source-on-digestion-and-performance-of-fattening-rabbits
#20
S Liangzhan, J Xiang, Z Caixia, F Zhaohui, L Fuchang
The objective of this study was to evaluate the use of oat hulls (OH) to substitute traditional fiber (a mixture of rice hulls and mugwort (RHM) leaf) in the diets of fattening rabbits by examining on its effect on the growth performance, coefficient of total tract apparent digestibility (CTTAD) of nutrients, gastrointestinal tract development, cecum fermentation and carcass traits. A total of 160 mixed sex Hyla commercial meat rabbits (40/treatment) were used to study the effects of including OH in the diet from 30 to 80 days of age...
November 8, 2016: Animal: An International Journal of Animal Bioscience
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