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https://www.readbyqxmd.com/read/28915951/male-contraception-prospects-for-sound-and-ultrasound
#1
Robert Sewak, Bettina Teng, Lee A Learman, Charles H Hennekens
The worldwide human population growth rate, which doubled during the 20th century, as well as the increasing fertility rate, have contributed to an increasing and evolving emphasis on contraception. With respect to female contraceptive methods, many have been developed, marketed, and are widely available. In contrast, male contraception has been limited to condoms, which pose logistical challenges, and vasectomy, which is largely irreversible. The use of sound to achieve effective and safe male contraception is a promising but unproven hypothesis...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28913590/challenges-of-anticoagulation-therapy-in-pregnancy
#2
REVIEW
Annemarie E Fogerty
Thrombotic complications in pregnancy represent a major cause of morbidity and mortality. Pregnancy is a primary hypercoagulable state due to enhanced production of clotting factors, a decrease in protein S activity, and inhibition of fibrinolysis. These physiologic changes will yield a collective rate of venous thromboembolism (VTE) of about 1-2 in 1000 pregnancies for the general obstetric population, which represents a five- to tenfold increased risk in pregnancy compared to age-matched non-pregnant peers...
September 14, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28913336/anti-interleukin-5-il-5-and-il-5ra-biological-drugs-efficacy-safety-and-future-perspectives-in-severe-eosinophilic-asthma
#3
REVIEW
Diego Bagnasco, Matteo Ferrando, Gilda Varricchi, Francesca Puggioni, Giovanni Passalacqua, Giorgio Walter Canonica
The definition of asthma has changed considerably in recent years, to the extent that asthma is no longer considered a single disease but a heterogeneous disorder that includes several phenotypes and, possibly, endotypes. A more detailed analysis of the immunological mechanisms underlying the pathogenesis of asthma shows interleukin 5 (IL-5) to be a crucial cytokine in several asthma phenotypes. In fact, IL-5 exerts selective action on eosinophils, which, in turn, sustain airway inflammation and worsen asthma symptoms and control...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28911302/what-is-the-real-efficacy-of-beta-blockers-for-the-treatment-of-essential-hypertension
#4
Christian Höcht, Facundo M Bertera, Julieta S Del Mauro, Yanina Santander Plantamura, Carlos A Taira, Ariel H Polizio
OBJECTIVE: This review covers the pharmacokinetics and pharmacodynamic of β-blockers, the rationale for their use, some recent controversies in its use for managing hypertension, as well as, the beneficial properties of the third-generation β-blockers beyond hypertension. BACKGROUND: The efficacy and safety of -blockers in the treatment of hypertension and other cardiovascular diseases have been established during more than 50 years of clinical experience. Recent updates of clinical guidelines have downgraded the use of -blockers for the treatment of uncomplicated hypertension to second and third line therapy...
June 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28904545/the-effects-of-massage-and-breastfeeding-on-response-to-venipuncture-pain-among-hospitalized-neonates
#5
Ali Zargham-Boroujeni, Azamolmolouk Elsagh, Majid Mohammadizadeh
BACKGROUND: Untreated procedural pain leads to long-term and short-term complications in neonates. Preventing pain in sick infants and neonates, whose conditions are getting worse, not only is a professional and legal duty but also a prevention measure to decrease future psychological and even neurological complications. Therefore, nurses should prevent newborns' pain. The aim of this study was to compare the effects of massage and breastfeeding on the pain of the neonates. MATERIALS AND METHODS: This was a clinical trial conducted among 75 full-term and near-term infants who underwent venipuncture...
July 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28904361/intrafascial-versus-interfascial-nerve-sparing-in-radical-prostatectomy-for-localized-prostate-cancer-a-systematic-review-and-meta-analysis
#6
Hong Weng, Xian-Tao Zeng, Sheng Li, Xiang-Yu Meng, Ming-Jun Shi, Da-Lin He, Xing-Huan Wang
The present study aimed to systematically evaluate the effectiveness and safety of the intrafascial and interfascial nerve sparing (ITR-NS and ITE-NS) radical prostatectomy. PubMed, Embase, and Cochrane Library databases were searched for eligible studies. Meta-analysis with random-effects model was performed. Six comparative trials were selected and embraced in this research, including one randomized controlled trial, three prospective comparative trials, and two retrospective comparative trials. With regard to perioperative parameters, no significant association of operative time, blood loss, transfusion rates, duration of catheterization, and hospital stay existed between ITR-NS and ITE-NS...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899655/characteristics-of-physical-activity-interventions-and-effects-on-cardiorespiratory-fitness-in-children-aged-6-12-years-a-systematic-review
#7
REVIEW
Petra Braaksma, Ilse Stuive, Rianne M E Garst, Carlijn F Wesselink, Corry K van der Sluis, Rienk Dekker, Marina M Schoemaker
OBJECTIVES: To examine the characteristics of physical activity (PA) interventions and the effects on cardiorespiratory fitness (CRF) in healthy children based on treatment theory. DESIGN: Systematic review. METHODS: PubMed and Embase were searched for studies published between 2003 and 2016. Inclusion criteria were: Participants: healthy children aged 6-12. INTERVENTIONS: interventions with activities to increase PA behaviour or physical fitness (PF) regardless of setting...
July 20, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28893527/management-of-premature-rupture-of-membranes-at-term-the-need-to-correct-a-recurring-mistake-in-articles-chapters-and-recommendations-of-professional-organizations
#8
Eyal Krispin
Recommendations about the management of premature rupture of membranes at term are based, in part, on a large, randomized controlled trial published in 1996: the "TERMPROM" trial. The original article contained an error in Table 1, in which "Interval from membrane rupture to delivery" was listed instead of "Interval from membrane rupture to study entry". While the authors and journal corrected this error, the mistake published in the original paper has made its way into subsequent publications and even in guidelines or practice bulletins issued by professional organizations, textbooks, and other publications around the world...
September 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28893523/-therapeutic-innovations-in-urology-for-localized-prostate-cancer
#9
L Cormier, G Créhange
The management of localized prostate cancer has been marked over these last years by the importance of Active Surveillance for low risk forms. Indeed, the long follow-up and the quality of the results are now sufficient to offer this option even in relatively young people. However, the question is still under investigation concerning intermediate risk of prostate cancer. Patients' selection and follow-up management are of very high importance. Another major evolution is the robotic assistance for radical prostatectomy...
September 8, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28893083/tissue-engineering-of-urethra-systematic-review-of-recent-literature
#10
Stanislav Žiaran, Martina Galambošová, L'uboš Danišovič
The purpose of this article was to perform a systematic review of the recent literature on urethral tissue engineering. A total of 31 articles describing the use of tissue engineering for urethra reconstruction were included. The obtained results were discussed in three groups: cells, scaffolds, and clinical results of urethral reconstructions using these components. Stem cells of different origin were used in many experimental studies, but only autologous urothelial cells, fibroblasts, and keratinocytes were applied in clinical trials...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28892156/a-randomized-controlled-trial-evaluating-polydextrose-as-a-fiber-in-a-wet-and-dry-matrix-on-glycemic-control
#11
Sajida Rahman, Anqi Zhao, Di Xiao, Eunyoung Park, Indika Edirisinghe, Britt M Burton-Freeman
Functional fibers can help Americans increase their fiber intake by incorporating extracted or synthesized fibers into food products. The United States Food and Drug Administration has recently proposed that "added" fibers must demonstrate a physiological health benefit, such as glucose control, to be included on the Nutrition Facts label as a dietary fiber. The objective of this study was to assess the effects of polydextrose (PDX), a water-soluble glucose polymer resistant to mammalian digestion, on postprandial glucose concentrations when added to relatively high moisture (beverage) versus low moisture (bar) food products...
September 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28891082/thrombolysis-for-massive-pulmonary-embolism-in-pregnancy
#12
Mojdeh S Heavner, Min Zhang, Chelsea E Bast, Lindsey Parker, Rachel F Eyler
Pregnant women are at high risk for venous thromboembolism, including pulmonary embolism (PE), given expected changes in coagulation, fibrinolysis, and venous blood flow. In fact, PE is the leading cause of maternal death in the United States. Non-pregnant patients who develop PE with hypotension or showing signs of deterioration after anticoagulation receive thrombolytics as a standard of care. Pregnant women, however, have been excluded from clinical trials with thrombolytics and all data available in this population is published as case reports or case series...
September 11, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28890662/-where-were-your-clothes-eliciting-descriptions-of-clothing-placement-from-children-alleging-sexual-abuse-in-criminal-trials-and-forensic-interviews
#13
Stacia N Stolzenberg, Thomas D Lyon
PURPOSE: The present study examined how children alleging sexual abuse are asked about clothing placement during abusive episodes, both in criminal trials and forensic interviews. The placement of clothing is of great importance, because it facilitates distinguishing abusive touch from non-abusive touch, as well as the severity of abuse when the touching is in fact sexual. If clothing has not been removed, then sexual abuse appears less likely and certain types of sexual contact are physically impossible (or at least highly improbable)...
September 2017: Legal and Criminological Psychology
https://www.readbyqxmd.com/read/28888101/what-s-new-in-sclc-a-review
#14
REVIEW
Bryan Oronsky, Tony R Reid, Arnold Oronsky, Corey A Carter
A few years ago the answer to the question in the title of this review would have been, "unfortunately not much" or even "nothing", likely eliciting knowing nods of agreement from oncologists. For the last 3 decades, SCLC has been notorious for its lack of progress, as drug after drug, over 60 of them, in fact, including inhibitors of VEGF, IGFR, mTOR, EGFR and HGF has failed and fallen by the wayside due to little or no impact on PFS or OS, while SCLC's cousin, NSCLC, has notched success after success with a spate of targeted treatment and immunotherapy regulatory approvals...
September 6, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28888030/increased-sign-tracking-behavior-in-adolescent-rats
#15
Nicole E DeAngeli, Sarah B Miller, Heidi C Meyer, David J Bucci
An autoshaping procedure was used to test the notion that conditioned stimuli (CSs) gain greater incentive salience during adolescence than young adulthood under conditions of social isolation rearing and food restriction. Rats were single-housed and placed on food restriction during 10 daily training sessions in which a lever (CS(+) ) was presented then followed immediately by a food unconditioned stimulus (US). A second lever (CS(-) ) was presented on intermixed trials and was not reinforced. Despite the fact that food delivery was not contingent on the rats' behavior, all rats exhibited behaviors directed towards the lever (i...
September 9, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28886734/promoting-physical-activity-in-worksite-settings-results-of-a-german-pilot-study-of-the-online-intervention-healingo-fit
#16
Kevin Dadaczynski, Stephan Schiemann, Olaf Backhaus
BACKGROUND: Worldwide, one third of the adult population is insufficiently physically active. This fact has led to a strong demand for public health initiatives. Given the mixed evidence on the effectiveness of worksite interventions promoting physical activity (PA), a pedometer-based and gamified intervention, Healingo Fit, was developed and evaluated over a period of six weeks. METHODS: The effectiveness of Healingo Fit was evaluated as part of a randomized controlled trial (RCT) with two measurement points involving employees of an automobile manufacturer...
September 8, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28886408/the-fate-of-distractors-in-working-memory-no-evidence-for-their-active-removal
#17
Isabelle Dagry, Pierre Barrouillet
Not all the information processed in working memory (WM) must be retained. Due to the strict limitations of its capacity, the mechanisms that prevent WM from being cluttered and choked by no longer relevant information are of paramount importance. The present study tested the hypothesis put forward by the SOB-CS model of an active and attention-demanding mechanism that would remove no-longer relevant items from WM. Such a mechanism has been advocated to account for the well-known fact that, in complex span tasks, processing distractors at a slower pace results in better recall of memory items...
September 5, 2017: Cognition
https://www.readbyqxmd.com/read/28886228/the-serum-heavy-light-chain-immunoassay-a-valuable-tool-for-sensitive-paraprotein-assessment-risk-and-disease-monitoring-in-monoclonal-gammopathies
#18
Christine Greil, Gabriele Ihorst, Felix Gaiser, Ulrich Salzer, Emanuel Bisse, Efstathios Kastritis, Heinz Ludwig, Ralph Wäsch, Monika Engelhardt
OBJECTIVE: The heavy/light chain (HLC)-immunoassay quantifies light chain types of each immunoglobulin class in patients with monoclonal gammopathies. METHODS: We assessed 147 consecutive patients with different forms and stages of plasma cell dyscrasias (PCD) who received standard tests (serum and urine protein electrophoresis [SPEP, UPEP], immunofixation [IFE], serum free light chain [SFLC]) and HLC-immunoassay. Patients with multiple myeloma (MM, n=102), smoldering MM (SMM, n=5), monoclonal gammopathy of undetermined significance (MGUS, n=28) and waldenström's macroglobulinemia (WM, n=12) were included...
September 8, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28886116/treatment-with-the-wnt5a-mimicking-peptide-foxy-5-effectively-reduces-the-metastatic-spread-of-wnt5a-low-prostate-cancer-cells-in-an-orthotopic-mouse-model
#19
Giacomo Canesin, Susan Evans-Axelsson, Rebecka Hellsten, Agnieszka Krzyzanowska, Chandra P Prasad, Anders Bjartell, Tommy Andersson
Prostate cancer patients with high WNT5A expression in their tumors have been shown to have more favorable prognosis than those with low WNT5A expression. This suggests that reconstitution of Wnt5a in low WNT5A-expressing tumors might be an attractive therapeutic approach. To explore this idea, we have in the present study used Foxy-5, a WNT5A mimicking peptide, to investigate its impact on primary tumor and metastasis in vivo and on prostate cancer cell viability, apoptosis and invasion in vitro. We used an in vivo orthotopic xenograft mouse model with metastatic luciferase-labeled WNT5A-low DU145 cells and metastatic luciferase-labeled WNT5A-high PC3prostate cancer cells...
2017: PloS One
https://www.readbyqxmd.com/read/28884267/diet-and-enteral-nutrition-in-patients-with-chronic-kidney-disease-not-on-dialysis-a-review-focusing-on-fat-fiber-and-protein-intake
#20
REVIEW
Alice Sabatino, Giuseppe Regolisti, Ilaria Gandolfini, Marco Delsante, Filippo Fani, Maria Cristina Gregorini, Enrico Fiaccadori
The clinical data available on dietary requirements of patients with chronic kidney disease (CKD) not on dialysis are limited and largely inconclusive in terms of the renal, cardiovascular and nutritional outcomes achievable through dietary modifications. Restriction of protein intake during the early stages of CKD may in fact slow its progression, but at the same time this approach may also lead to protein-energy wasting, if energy intake is not adequate and properly monitored. Unfortunately, compliance to dietary recommendations is traditionally low in this patient population...
September 7, 2017: Journal of Nephrology
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