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https://www.readbyqxmd.com/read/28431145/long-term-effects-of-a-lifestyle-intervention-and-oral-glucosamine-sulphate-in-primary-care-on-incident-knee-oa-in-overweight-women
#1
Bastiaan C de Vos, Marieke L A Landsmeer, Marienke van Middelkoop, Edwin H G Oei, Marjolein Krul, Sita M A Bierma-Zeinstra, Jos Runhaar
Objectives.: The present study was designed to evaluate the effect of a lifestyle intervention aimed to reduce body weight and of oral glucosamine sulphate on the incidence of knee osteoarthritis (OA) after 6-7 years in a population of middle-aged, overweight women, without knee OA at baseline. Methods.: The Prevention of knee Osteoarthritis in Overweight Females study, ISRCTN42823086, was a randomized controlled trial with a 2 × 2 factorial design. Four hundred and seven women aged 50-60 years with a BMI of ⩾27 kg/m 2 and free of knee OA were randomized...
April 20, 2017: Rheumatology
https://www.readbyqxmd.com/read/28428885/the-why-what-and-how-of-the-new-fact-standards-for-immune-effector-cells
#2
EDITORIAL
Marcela V Maus, Sarah Nikiforow
Novel cellular therapies outside of traditional hematopoietic stem cell transplantation or hematopoietic progenitor cell (HPC) therapy are currently under evaluation in clinical trials across the United States and around the world. Several cellular products, e.g., CD19-directed Chimeric Antigen Receptor (CAR) T cells, are poised for FDA approval and thus increased use at a wider range of academic centers within the next year, with the likelihood of dissemination to standard oncology practice once safety is confirmed...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28427805/confounding-causality-and-confusion-the-role-of-intermediate-variables-in-interpreting-observational-studies-in-obstetrics
#3
Cande V Ananth, Enrique F Schisterman
Both prospective and retrospective cohort, and case-control studies are some of the most important study designs in epidemiology because, under certain assumptions, they can mimic a randomized trial when done well. These assumptions include but not limited to properly accounting for two important sources of bias: confounding and selection bias. While not adjusting the causal association for an intermediate variable will yield an unbiased estimate of the exposure-outcome's total causal effect, it is often that obstetricians will want to adjust for an intermediate variable to assess if the intermediate is the underlying driver of the association...
April 17, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28426834/acceptability-of-an-open-label-wait-listed-trial-design-experiences-from-the-proud-prep-study
#4
Mitzy Gafos, Elizabeth Brodnicki, Monica Desai, Sheena McCormack, Will Nutland, Sonali Wayal, Ellen White, Gemma Wood, Tristan Barber, Gill Bell, Amanda Clarke, David Dolling, David Dunn, Julie Fox, Lewis Haddow, Charles Lacey, Anthony Nardone, Killian Quinn, Caroline Rae, Iain Reeves, Michael Rayment, David White, Vanessa Apea, Wilbert Ayap, Claire Dewsnap, Yolanda Collaco-Moraes, Gabriel Schembri, Yinka Sowunmi, Rob Horne
BACKGROUND: PROUD participants were randomly assigned to receive pre-exposure prophylaxis (PrEP) immediately or after a deferred period of one-year. We report on the acceptability of this open-label wait-listed trial design. METHODS: Participants completed an acceptability questionnaire, which included categorical study acceptability data and free-text data on most and least liked aspects of the study. We also conducted in-depth interviews (IDI) with a purposely selected sub-sample of participants...
2017: PloS One
https://www.readbyqxmd.com/read/28426819/virological-success-after-12-and-24-months-of-antiretroviral-therapy-in-sub-saharan-africa-comparing-results-of-trials-cohorts-and-cross-sectional-studies-using-a-systematic-review-and-meta-analysis
#5
Fabien Taieb, Yoann Madec, Amandine Cournil, Eric Delaporte
BACKGROUND: UNAIDS recently defined the 90-90-90 target as a way to end the HIV epidemic. However, the proportion of virological success following antiretroviral therapy (ART) may not be as high as the anticipated 90%, and may in fact be highly heterogeneous. We aimed to describe the proportion of virological success in sub-Saharan Africa and to identify factors associated with the proportion of virological success. METHODS: We performed a systematic review and meta-analysis focusing on the proportion of patients in sub-Saharan Africa who demonstrate virological success at 12 and 24 months since ART initiation, as well as at 6 and 36 months, where possible...
2017: PloS One
https://www.readbyqxmd.com/read/28426802/decoding-the-infant-mind-multivariate-pattern-analysis-mvpa-using-fnirs
#6
Lauren L Emberson, Benjamin D Zinszer, Rajeev D S Raizada, Richard N Aslin
The MRI environment restricts the types of populations and tasks that can be studied by cognitive neuroscientists (e.g., young infants, face-to-face communication). FNIRS is a neuroimaging modality that records the same physiological signal as fMRI but without the constraints of MRI, and with better spatial localization than EEG. However, research in the fNIRS community largely lacks the analytic sophistication of analogous fMRI work, restricting the application of this imaging technology. The current paper presents a method of multivariate pattern analysis for fNIRS that allows the authors to decode the infant mind (a key fNIRS population)...
2017: PloS One
https://www.readbyqxmd.com/read/28425820/metastatic-soft-tissue-sarcoma-current-treatment-landscape-and-future-perspectives
#7
E Skafida, S Kokkali, M Nikolaou, A Digklia
The therapeutic armamentarium for advanced soft tissue sarcoma (STS) has increased over the last few years. Doxorubicin monotherapy or in combination is now the established first line treatment. Beyond first line treatment, no standard therapy has been established. Novel drugs have reached the late-clinical stage development demonstrating to be effective in controlled studies. While these novel treatments can be beneficial to a subset of patients, even producing long lasting remissions, a significant fraction of the STS population derives limited benefit...
April 20, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28424902/physical-and-psychosocial-aspects-of-adolescent-and-young-adults-after-allogeneic-hematopoietic-stem-cell-transplantation-results-from-a-prospective-multicenter-trial
#8
Kristin Pulewka, Daniel Wolff, Philipp Y Herzberg, Hildegard Greinix, Pia Heussner, Friederike H A Mumm, Stephanie von Harsdorf, Kathrin Rieger, Philipp Hemmati, Andreas Hochhaus, Inken Hilgendorf
PURPOSE: Allogeneic hematopoietic stem-cell transplantation (alloHSCT) is physically and psychosocially demanding. Among transplant recipients, adolescent and young adults (AYA) represent a special group, as disease occurs early in life, resulting in the prospect of long survival time and high burden of alloHSCT sequelae. However, data focusing on AYA undergoing alloHSCT are rare. METHODS: Data resulting from a prospective multicenter trial initially focusing on graft-versus-host disease (GvHD) after alloHSCT were reused to analyse the differences between AYA and elderly patients...
April 19, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28423038/attentional-bias-modification-training-for-insomnia-a-double-blind-placebo-controlled-randomized-trial
#9
Jaap Lancee, Samya L Yasiney, Ruben S Brendel, Marilisa Boffo, Patrick J F Clarke, Elske Salemink
BACKGROUND: Attentional bias toward sleep-related information is believed to play a key role in insomnia. If attentional bias is indeed of importance, changing this bias should then in turn have effects on insomnia complaints. In this double-blind placebo controlled randomized trial we investigated the efficacy of attentional bias modification training in the treatment of insomnia. METHOD: We administered baseline, post-test, and one-week follow-up measurements of insomnia severity, sleep-related worry, depression, and anxiety...
2017: PloS One
https://www.readbyqxmd.com/read/28420805/immunotherapeutic-approaches-for-hepatocellular-carcinoma
#10
Vito Longo, Antonio Gnoni, Andrea Casadei Gardini, Salvatore Pisconti, Antonella Licchetta, Mario Scartozzi, Riccardo Memeo, Vincenzo Ostilio Palmieri, Giuseppe Aprile, Daniele Santini, Patrizia Nardulli, Nicola Silvestris, Oronzo Brunetti
Hepatocellular carcinoma (HCC) is a cancer with a high mortality rate due to the fact that the diagnosis usually occurs at anadvanced stage. Even in case of curative surgical treatment, recurrence is common. Sorafenib and regorafenib are the only therapeutic agents that have been demonstrated to be effective in advanced HCC, thus novel curative approaches are urgently needed. Recent studies focus on the role of immune system in HCC. In fact, the unique immune response in the liver favors tolerance, which can represent a real challenge for conventional immunotherapy in these patients...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417296/dpp4-inhibitors-and-cardiovascular-outcomes-safety-on-heart-failure
#11
REVIEW
Chang Xia, Aditya Goud, Jason D'Souza, CHanukya Dahagam, Xiaoquan Rao, Sanjay Rajagopalan, Jixin Zhong
Diabetes is an important risk factor for cardiovascular disease. However, clinical data suggests intensive glycemic control significantly increase rather than decrease cardiovascular mortality, which is largely due to the fact that a majority of oral anti-diabetic drugs have adverse cardiovascular effect. There are several large-scale clinical trials evaluating the cardiovascular safety of DPP4 inhibitors, a novel class of oral anti-diabetic medications, which have been recently completed. They were proven to be safe with regard to cardiovascular outcomes...
April 18, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28413977/new-suggestions-in-sublingual-immunotherapy-for-house-dust-mite-related-allergic-diseases
#12
Matteo Ferrando, Diego Bagnasco, Giovanni Passa-Lacqua, Francesca Puggioni, Gilda Varricchi, Giorgio Walter Canonica
BACKGROUND: The indications for Allergen immunotherapy (AIT) in patients suffering from House Dust Mite (HDM)-related allergic diseases are presently based on incomplete data. This is essentially based on the fact that HDM allergy is difficult to evaluate in clinical trials, due to the largely variable allergen exposure and symptoms, and to the long periods of observation needed to assess the effects. In addition, at variance with pollen allergy, in HDM allergy asthma is more prevalent...
April 17, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28411016/gene-therapy-for-hemophilia
#13
REVIEW
Arthur W Nienhuis, Amit C Nathwani, Andrew M Davidoff
The X-linked bleeding disorder hemophilia causes frequent and exaggerated bleeding that can be life-threatening if untreated. Conventional therapy requires frequent intravenous infusions of the missing coagulation protein (factor VIII [FVIII] for hemophilia A and factor IX [FIX] for hemophilia B). However, a lasting cure through gene therapy has long been sought. After a series of successes in small and large animal models, this goal has finally been achieved in humans by in vivo gene transfer to the liver using adeno-associated viral (AAV) vectors...
April 11, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28410504/exercise-training-in-older-adults-what-effects-on-muscle-oxygenation-a-systematic-review
#14
REVIEW
Elie Fiogbé, Verena de Vassimon-Barroso, Anielle Cristhine de Medeiros Takahashi
AIM: To determine the effects of different modality of exercise training programs on muscle oxygenation in older adults. METHODS: Relevant articles were searched in PubMed, Web of Science, Science Direct and Scopus, using the keywords: "Aged" AND "Muscle oxygenation" AND (Exercise OR "Exercise therapy" OR "Exercise Movement Techniques" OR Hydrotherapy), without limitation concerning the publication date. To be included in the full analysis, the study had to be a randomized controlled trial in which older adults participants (mean age: 65 years at least) were submitted to an exercise-training program and muscle oxygenation assessment...
March 20, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28409169/the-effectiveness-of-a-peer-coaching-education-on-control-and-management-of-type-2-diabetes-in-women-a-protocol-for-a-randomized-controlled-trial
#15
Maryam Aalaa, Mahnaz Sanjari, Hamid Reza Aghaei Meybodi, Mohammad Reza Amini, Mostafa Qorbani, Hossien Adibi, Neda Mehrdad
BACKGROUND: Diabetes Education by Peer Coaching is a strategy which helps the patients with diabetes in the field of behavioral and emotional problems. However, the results of studies in this field in other countries could not be generalized in our context. So, the current study aimed to examine the effectiveness of Diabetes Education by Peer Coaching on Diabetes Management. METHODS: Outcome variables for patients and peer coaches are measured at baseline and in3,6 and 12 months...
April 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/28405854/development-of-a-new-method-for-the-preparation-of-an-acellular-allodermis-quality-control-and-cytotoxicity-testing
#16
J Dragúňová, P Kabát, P Babál, H Mrázová, M Boháč, Ľ Krajčíová, J Koller
Demand for use of acellular allodermis is high but commercially appropriate products are not used routinely because of very high price and limited availability. These facts did motivate us to prepare acellular allodermis using a new, simple and less expensive method. We have developed a original method for preparation of acellular allogeneic dermis based on action of a proteolytic enzyme in combination with distilled water. Hypotonic environment in comparison with SDS or Triton ansure no toxicity of the final product...
April 12, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28403323/a-critical-review-of-trials-of-transcranial-direct-current-stimulation-and-trigeminal-nerve-stimulation-for-depression-the-issue-of-treatment-emergent-mania
#17
REVIEW
Pedro Shiozawa, Quirino Cordeiro, Hyong Jin Cho, Alisson Paulino Trevizol, Elisa Brietzke
Objective: This study is a critical review analyzing occurrence of treatment-emergent mania (TEM) related to transcranial direct current stimulation (tDCS) and trigeminal nerve stimulation (TNS). Method: We present a systematic review of the literature on TEM related to tDCS and TNS treatment for major depressive disorder (MDD), conducted in accordance with the recommendations from Cochrane Group and the PRISMA guidelines. Results: Our search identified few reported episodes of TEM in the literature...
January 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28398017/differential-effects-of-phosphodiesterase-5-inhibition-in-chronic-cardiac-decompensation-depending-on-the-type-whether-hfref-or-hfpef-of-heart-failure-a-meta-analysis
#18
Renato DE Vecchis, Arturo Cesaro, Carmelina Ariano
INTRODUCTION: According to 2015 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension(PH), no specific drug is currently indicated for PH related to left heart disease( PH-LDH), i.e., the one secondary to left chronic heart failure (CHF), which coincides with the group 2 of the PH classification endorsed by the above-mentioned guidelines. In fact, adoption of therapies that specifically apply for so-called pulmonary arterial hypertension (group 1 of the PH classification) has been regarded as substantially contraindicated in patients with PH- LHD, according to current ESC/ERS guidelines...
April 10, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28397501/layer-by-layer-assembled-laccase-enzyme-on-stimuli-responsive-membranes-for-chloro-organics-degradation
#19
Rupam Sarma, Md Saiful Islam, Anne-Frances Miller, Dibakar Bhattacharyya
Functionalized membranes provide versatile platforms for the incorporation of biocatalysts and nanostructured materials for efficient and benign environmental remediation. The existing techniques for remediating chloro-organics in water consist of both physical and chemical means mostly using metal oxide-based catalysts, despite associated environmental concerns. To offer bioinspired remediation as an alternative, we herein demonstrate a layer-by-layer approach to immobilize laccase enzyme onto pH-responsive functionalized membranes for the degradation of chloro-organics in water...
April 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28387340/advances-in-neuro-oncology-imaging
#20
REVIEW
Karl-Josef Langen, Norbert Galldiks, Elke Hattingen, Nadim Jon Shah
Despite the fact that MRI has evolved to become the standard method for diagnosis and monitoring of patients with brain tumours, conventional MRI sequences have two key limitations: the inability to show the full extent of the tumour and the inability to differentiate neoplastic tissue from nonspecific, treatment-related changes after surgery, radiotherapy, chemotherapy or immunotherapy. In the past decade, PET involving the use of radiolabelled amino acids has developed into an important diagnostic tool to overcome some of the shortcomings of conventional MRI...
April 7, 2017: Nature Reviews. Neurology
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