Robert Silasi, Ravi Shankar Keshari, Cristina Lupu, Walter Janse Van Rensburg, Hala Chaaban, Girija Regmi, Aleksandr Shamanaev, Joseph J Shatzel, Cristina Puy, Christina U Lorentz, Erik I Tucker, David Gailani, András Gruber, Owen J T McCarty, Florea Lupu
Staphylococcus aureus infections can produce systemic bacteremia and inflammation in humans, which may progress to severe sepsis or septic shock, even with appropriate antibiotic treatment. Sepsis may be associated with disseminated intravascular coagulation and consumptive coagulopathy. In some types of mouse infection models, the plasma coagulation protein factor XI (FXI) contributes to the pathogenesis of sepsis. We hypothesize that FXI also contributes to the pathogenesis of sepsis in primates, and that pharmacological interference with FXI will alter the outcome of Staphylococcus aureus -induced lethality in a baboon model...
February 26, 2019: Blood Advances