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Anti- inflammatory therapies

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https://www.readbyqxmd.com/read/30222011/current-developments-in-pharmacotherapy-for-actinic-keratosis
#1
Elena Campione, Alessandra Ventura, Laura Diluvio, Mauro Mazzeo, Sara Mazzilli, Virginia Garofalo, Monia Di Prete, Luca Bianchi
Actinic keratosis (AK) is considered as a superficial squamous cell carcinoma (SCC). A central role in the pathogenesis is played by chronic sun exposure. UVB causes direct damage to DNA, producing pyrimidine dimers, and suppressing the protective role of p53. The stepwise progression of AK, with an increased expression of anti-apoptotic Bcl-2, favors the progression to SCC. Moreover, the dermal response characterized by inflammation and mediated by prostaglandins is a critical component of tumorigenesis that promotes tumor growth, tissue invasion, angiogenesis and metastasis...
September 17, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/30221933/targeting-neuroinflammation-as-a-therapeutic-strategy-for-alzheimer-s-disease-mechanisms-drug-candidates-and-new-opportunities
#2
Wing-Yu Fu, Xiujiao Wang, Nancy Y Ip
Alzheimer's disease is a progressive neurodegenerative disease, and its incidence is expected to increase owing to the aging population worldwide. Current therapies merely provide symptomatic relief. Therefore, interventions for AD that delay the disease onset or progression are urgently required. Recent genomics and functional studies suggest that immune/inflammatory pathways are involved in the pathogenesis of AD. Although many anti-inflammatory drug candidates have undergone clinical trials, most have failed...
September 17, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/30221336/is-a-combination-of-antibiotics-and-non-steroidal-anti-inflammatory-drugs-more-beneficial-than-antibiotic-monotherapy-for-the-treatment-of-female-acute-uncomplicated-cystitis-a-randomized-controlled-pilot-study
#3
Kyungtae Ko, Won Ki Lee, Cheol Young Oh, Seong Ho Lee, Sung Tae Cho, Woo Jin Bang, Tae Young Shin, Min Soo Choo, Jin Seon Cho, Young Goo Lee, Dae Yul Yang
 Purpose: To compare the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) combination therapy to single-agent antibiotic therapy for the resolution of symptoms during two restricted activity days in patients with acute uncomplicated cystitis (AUC)Materials and Methods: We performed a prospective, randomized control pilot study. A total of 55 patients were enrolled. Group I (n=28) was treated with cepodoxime (100 mg twice per day), and Group II (n=27) was treated with cepodoxime (100 mg) and aceclofenac (100 mg) twice per day; both groups were treated for three days...
September 16, 2018: Urology Journal
https://www.readbyqxmd.com/read/30221099/thoracic-discitis-in-ankylosing-spondylitis
#4
Eamon Maloney, Sachin Srinivasan, Timothy Shaver
Chronic ankylosing spondylitis can lead to several rare long-term complications including cauda equina syndrome and inflammatory discitis especially without treatment. These complications are uncommon, but there is evidence that they can be treated with anti-tumor necrosis factor (TNF) inhibitors. We present a case of a 52-year-old male with a 30-year history of undiagnosed ankylosing spondylitis with cauda equina syndrome on initial outpatient presentation with a negative lumbosacral magnetic resonance imaging (MRI)...
July 12, 2018: Curēus
https://www.readbyqxmd.com/read/30220554/inhibition-of-atypical-protein-kinase-c-reduces-inflammation-induced-retinal-vascular-permeability
#5
Cheng-Mao Lin, Paul M Titchenell, Jason M Keil, Adolfo Garcia-Ocaña, Mark T Bolinger, Steven F Abcouwer, David A Antonetti
Changes in permeability of retinal blood vessels contribute to macular edema and the pathophysiology of numerous ocular diseases, including diabetic retinopathy, retinal vein occlusions, and macular degeneration. Vascular endothelial growth factor (VEGF) induces retinal permeability and macular thickening in these diseases. However, inflammatory agents, such as tumor necrosis factor-α (TNF-α), also may drive vascular permeability, specifically in patients unresponsive to anti-VEGF therapy. Recent evidence suggests VEGF and TNF-α induce permeability through distinct mechanisms; however, both require the activation of atypical protein kinase C (aPKC)...
September 12, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/30220453/angioedema-and-emergency-medicine-from-pathophysiology-to-diagnosis-and-treatment
#6
REVIEW
Federica Depetri, Alberto Tedeschi, Massimo Cugno
Angioedema is a self-limiting edema of the subcutaneous or submucosal tissues due to localised increase of microvascular permeability whose mediator may be histamine or bradykinin. Patients present to emergency department when angioedema involves oral cavity and larynx (life-threatening conditions) or gut (mimicking an acute abdomen). After initial evaluation of consciousness and vital signs to manage breathing and to support circulation if necessary, a simple approach can be applied for a correct diagnosis and treatment...
September 13, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/30220289/-research-progress-on-inflammation-and-right-ventricular-failure
#7
Hui Zhang, Yujuan Bao, Xiangrong Zuo
Right ventricular failure (RVF) is the main cause of death in patients with cardiopulmonary disease, such as pulmonary arterial hypertension (PAH), pulmonary embolism, acute respiratory distress syndrome, and right ventricular infarction. The exact cellular and molecular mechanisms underlying RVF remains unclear. Inflammation may play an important role during the development of RVF, as it does in left heart failure. Cardiac inflammation has been shown in RVF patients and animal models, which played a role in the impairment of the right ventricular contraction and in the maladaptive remodeling...
August 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/30219743/nmosd-with-anti-mog-antibodies-following-anti-tnf%C3%AE-therapy-a-case-report
#8
Lommers Emilie, Depierreux Frédérique, Hansen Isabelle, Dive Dominique, Maquet Pierre
Tumor necrosis factor α (TNFα) inhibitors are highly effective and a therapeutic choice for several inflammatory diseases. Their broad and long-term use is associated with a growing number of paradoxical autoimmune events including demyelinating lesions of the central nervous system (CNS). We report and discuss a case of neuromyelitis optica spectrum disorder (NMOSD) with positive myelin oligodendrocyte glycoprotein antibodies (MOG-IgG1) following anti-TNFα therapy for a pustular psoriasis.
August 31, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/30219433/spirulina-platensis-effectively-ameliorates-anthropometric-measurements-and-obesity-related-metabolic-disorders-in-obese-or-overweight-healthy-individuals-a-randomized-controlled-trial
#9
Reyhaneh Yousefi, Azadeh Mottaghi, Atoosa Saidpour
AIMS: Novel alternative treatments such as food supplements may be an effective approach to weight management. The aim of the present study was to investigate the possible effects of Spirulina Platensis (SP) on anthropometric measures, appetite and metabolic parameters in obese or overweight individuals. MATERIAL AND METHODS: A total of fifty-two obese and overweight subjects (25 kg/m2  ≤ body mass index (BMI) <40 kg/m2 ) were randomly selected to be allocated to SP (4 × 500 mg daily tablets along with restricted calorie diet (RCD)) or placebo (placebo tablets along with RCD) for 12 weeks of intervention...
October 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/30219389/il-17a-is-functionally-relevant-and-a-potential-therapeutic-target-in-bullous-pemphigoid
#10
Lenche Chakievska, Maike M Holtsche, Axel Künstner, Stephanie Goletz, Britt-Sabina Petersen, Diamant Thaci, Saleh M Ibrahim, Ralf J Ludwig, Andre Franke, Christian D Sadik, Detlef Zillikens, Christoph Hölscher, Hauke Busch, Enno Schmidt
IL-17A has been identified as key regulatory molecule in several autoimmune and chronic inflammatory diseases followed by the successful use of anti-IL-17 therapy, e.g. in ankylosing spondylitis and psoriasis. Bullous pemphigoid (BP) is the most frequent autoimmune blistering disease with a high need for more specific, effective and safe treatment options. The aim of this study was to clarify the pathophysiological importance of IL-17A in BP. We found elevated numbers of IL-17A+ CD4+ lymphocytes in the peripheral blood of BP patients and identified CD3+ cells as major source of IL-17A in early BP skin lesions...
September 12, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/30218777/chitosan-silk-fibroin-modified-nanofibrous-patches-with-mesenchymal-stem-cells-prevent-heart-remodeling-post-myocardial-infarction-in-rats
#11
Jiangwei Chen, Yingfei Zhan, Yabin Wang, Dong Han, Bo Tao, Zhenli Luo, Sai Ma, Qun Wang, Xiang Li, Fan Li, Congye Li, Hongbing Deng, Feng Cao
Poor functional survival of the engrafted stem cells limits the therapeutic efficacy of stem-cell-based therapy for myocardial infarction (MI). Cardiac patch-based system for cardiac repair has emerged as a potential regenerative strategy for MI. This study aimed to design a cardiac patch to improve the retention of the engrafted stem cells and provide mechanical scaffold for preventing the ventricular remodeling post-MI. The patches were fabricated with electrospinning cellulose nanofibers modified with chitosan/silk fibroin (CS/SF) multilayers via layer-by-layer (LBL) coating technology...
September 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30218200/-progressive-respiratory-failure-and-weakness-in-a-61-year-old-woman
#12
M Mahmud, U Schnoor, O M Steinmetz
A 61-year-old woman was admitted with a suspected diagnosis of atypical pneumonia. Extended diagnostic measures revealed interstitial lung disease (ILD), polyserositis, polyarthritis and myopathy. With detection of an antibody against PL-7 (anti-threonyl-transfer-RNA synthetase) the diagnosis of anti-synthetase syndrome (ASS) was established. ASS are rare inflammatory myopathies which frequently present as multisystemic diseases with severe organ involvement. An immunosuppressive regimen with steroids and cyclophosphamide led to successful induction of disease remission...
September 14, 2018: Der Internist
https://www.readbyqxmd.com/read/30217504/mesenchymal-stem-cell-treatment-attenuates-liver-and-lung-inflammation-after-ethanol-intoxication-and-burn-injury
#13
Brenda J Curtis, Jill A Shults, Devin M Boe, Luis Ramirez, Elizabeth J Kovacs
Cutaneous burn injury is one of the most devastating injuries one can obtain with tissue damage extending beyond the skin wound to distal organs, including the gastrointestinal tract, liver, and lungs. Multiple organ failure is a leading cause of death after burn injury resulting in excessive systemic and localized inflammation directly contributing to end organ damage. We postulated that the gut-liver-lung inflammatory axis underscores multiple organ failure in the context of burn injury and is hyper-activated when ethanol intoxication precedes burn...
September 11, 2018: Alcohol
https://www.readbyqxmd.com/read/30217479/4-hydroxywogonin-inhibits-colorectal-cancer-angiogenesis-by-disrupting-pi3k-akt-signaling
#14
Dongdong Sun, Feng Zhang, Jie Qian, Weixing Shen, Huisen Fan, Jiani Tan, Liu Li, Changliang Xu, Ye Yang, Haibo Cheng
Angiogenesis is fundamental for solid tumor growth and metastasis, and anti-angiogenic therapy has been an important therapeutic option for cancer treatment. Colorectal cancer (CRC) represents the fourth leading cause of cancer-related death worldwide. The current studies were aimed at investigating the anti-angiogenic effects of the natural compound 4'-hydroxywogonin (4'-HW) on CRC-related angiogenesis. Human CRC cell line SW620 cells and normal human intestinal epithelial HIEC cells were cultured and treated with interleukin-6 to mimic the tumor inflammatory microenvironment...
September 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/30217346/-bilateral-pulmonary-embolism-revealing-granulomatosis-with-polyangiitis
#15
S El Aoud, H Tounsi, I Chaabène, B Ben Ammou, I Ben Ahmed, W Garbouj, K Bouzeidi, R Amri
Granulomatosis with polyangiitis is a systemic small-vessels vasculitis. It is characterized by a granulomatous inflammatory reaction around the arterial wall and is, in most cases, accompanied by the presence of cytoplasmic - type anti-neutrophil cytoplasmic antibodies (ANCA) with anti-proteinase 3 specificity. The predominant clinical presentation is frequent involvement of the upper and lower respiratory tract and the kidneys. This vasculitis is rarely revealed by pulmonary embolism. We report the observation of a 47-year-old male who presented with acute dyspnea...
September 2018: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/30217263/rhein-augments-atra-induced-differentiation-of-acute-promyelocytic-leukemia-cells
#16
Sook-Kyoung Heo, Eui-Kyu Noh, Jeong Yi Kim, SungHoo Jegal, Yookyung Jeong, Jaekyung Cheon, SuJin Koh, Jin Ho Baek, Young Joo Min, Yunsuk Choi, Jae-Cheol Jo
BACKGROUND: Rhein (4, 5-dihydroxyanthraquinone-2-carboxylic acid), a natural anthraquinone derivative, is a traditional Chinese herb that has been used as a medication in many Asian countries. It has been used as a laxative and stomach drug for a long time in both China and Korea. It is well-known to have many pharmacological activities, such as anti-cancer, anti-bacterial, anti-fungal, anti-oxidant, anti-atherogenic, anti-angiogenic, anti-fibrosis, anti-inflammatory, hepatoprotective, and nephroprotective properties...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30216977/the-anti-inflammatory-effects-of-vitamin-d-in-tumorigenesis
#17
REVIEW
Wei Liu, Lei Zhang, Hui-Jing Xu, Yan Li, Chuan-Min Hu, Jing-Yan Yang, Mei-Yan Sun
In conjunction with the classical functions of regulating intestinal, bone, and kidney calcium and phosphorus absorption, as well as bone mineralization of vitamin D, the population-based association between low vitamin D status and increased cancer risk is now generally accepted. Inflammation is causally related to oncogenesis. It is widely thought that vitamin D plays an important role in the modulation of the inflammation system by regulating the production of inflammatory cytokines and immune cells, which are crucial for the pathogenesis of many immune-related diseases...
September 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30216787/second-generation-atypical-antipsychotics-olanzapine-and-aripiprazole-reduce-expression-and-secretion-of-inflammatory-cytokines-in-human-immune-cells
#18
Britta Stapel, Irina Sieve, Christine S Falk, Stefan Bleich, Denise Hilfiker-Kleiner, Kai G Kahl
Schizophrenia and major depression are associated with alterations in peripheral inflammatory markers, and anti-inflammatory therapy has been proposed as a promising add-on approach in the pharmacologic treatment of both disorders. Second-generation atypical antipsychotics are currently first-line drugs in the treatment of schizophrenia and are also used as augmentation strategies in treatment-resistant major depression. Furthermore, these drugs have been reported to exhibit distinct metabolic side effects and to influence inflammatory processes...
September 4, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/30216732/new-and-emerging-therapies-for-pulmonary-arterial-hypertension
#19
Edda Spiekerkoetter, Steven M Kawut, Vinicio A de Jesus Perez
Pulmonary arterial hypertension (PAH) is a pulmonary vasculopathy that causes right ventricular dysfunction and exercise limitation and progresses to death. New findings from translational studies have suggested alternative pathways for treatment. These avenues include sex hormones, genetic abnormalities and DNA damage, elastase inhibition, metabolic dysfunction, cellular therapies, and anti-inflammatory approaches. Both novel and repurposed compounds with rationale from preclinical experimental models and human cells are now in clinical trials in patients with PAH...
September 14, 2018: Annual Review of Medicine
https://www.readbyqxmd.com/read/30216653/mesenchymal-stromal-cell-potency-to-treat-acute-kidney-injury-increased-by-ultrasound-activated-interferon-%C3%AE-interleukin-10-axis
#20
Scott R Burks, Matthew E Nagle, Michele N Bresler, Saejeong J Kim, Robert A Star, Joseph A Frank
Mesenchymal stromal cell (MSC) therapies combined with renal pulsed focused ultrasound (pFUS) pretreatment increase MSC homing and improve cisplatin-induced acute kidney injury (AKI) better than MSC alone. However, mechanisms underlying improved outcomes remain unknown. We hypothesize pFUS up-regulates renal interferon-γ (IFNγ) and stimulates MSC to produce interleukin-10 (IL-10) after migrating to kidneys. To demonstrate initially, MSC cultured with IFNγ up-regulated IL-10. More MSC-derived IL-10 was detected in kidneys when IFNγ-stimulated MSC were infused and they improved AKI better than unstimulated MSC...
September 14, 2018: Journal of Cellular and Molecular Medicine
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