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https://www.readbyqxmd.com/read/30444345/using-small-molecule-adjuvants-to-repurpose-azithromycin-for-use-against-pseudomonas-aeruginosa
#1
Veronica Hubble, Brittany A Hubbard, Bradley Minrovic, Roberta Melander, Christian Melander
A major contributor to fatality in cystic fibrosis (CF) patients stems from infection with the opportunistic bacterium Pseudomonas aeruginosa. As a result of the CF patient's vulnerability to bacterial infections, one of the main treatment focuses is antibiotic therapy. However, the highly adaptive nature of P. aeruginosa, in addition to the intrinsic resistance to many antibiotics exhibited by most Gram-negative bacteria, means that multi-drug resistant (MDR) strains are increasingly prevalent. This makes eradication of pseudomonal lung infections nearly impossible once the infection becomes chronic...
November 16, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/30443715/resolvin-d2-relieving-radicular-pain-is-associated-with-regulation-of-inflammatory-mediators-akt-gsk-3%C3%AE-signal-pathway-and-gpr18
#2
Lan-Yu Zhang, Zhi-Hua Liu, Qing Zhu, Shuang Wen, Cong-Xian Yang, Zhi-Jian Fu, Tao Sun
Neuroinflammation induced by protruded nucleus pulposus (NP) has been shown to play a significant role in facilitation of radicular pain. Resolvin D2 (RvD2), a novel member of resolvin family, exhibits potent anti-inflammatory, pro-resolving and antinociceptive effects. But the effect of RvD2 in radicular pain remains unknown. The radicular pain rat models were induced by application of NP to L5 dorsal root ganglion. Each animal received intrathecal injections of vehicle or RvD2 (10 ng µl-1 or 100 ng µl-1 )...
November 15, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/30443024/a-standardized-herbal-extract-pm014-ameliorates-pulmonary-fibrosis-by-suppressing-the-tgf-%C3%AE-1-pathway
#3
Kyung Hwa Kim, Sujin Lee, Hyunji Lee, Dasom Shin, Daeun Min, Miran Kim, Byeol Ryu, Hyeon Woo Kim, Hyunsu Bae
Idiopathic pulmonary fibrosis (IPF) is a devastating and common chronic lung disease pathologically characterized by loss of epithelial cells and activation of fibroblasts and myofibroblasts. The etiology of IPF remains unclear and the disease pathology is poorly understood with no known efficacious therapy. PM014 is an herbal extract that has been shown to have beneficial effects in pulmonary diseases, which are likely to exert anti-inflammatory bioactions. In the present study, we observed that bleomycin (BLM) caused increased inflammatory infiltration as well as collagen deposition in lungs of mice on day 14 after treatment...
November 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30443016/effector-and-regulatory-b-cells-in-immune-mediated-kidney-disease
#4
REVIEW
Kristine Oleinika, Claudia Mauri, Alan D Salama
B cells have a central role in many autoimmune diseases, including in those with renal involvement, as well as in the immunological response to kidney transplantation. The majority of B cell studies have focused on their pathological role as antibody producers. However, these cells have broad functions in immune responses beyond immunoglobulin secretion, including antigen presentation to T cells and cytokine production. Importantly, not all B cell subsets enhance immune responses. Regulatory B (Breg ) cells attenuate inflammation and contribute to the maintenance of immune tolerance...
November 15, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30441971/potential-of-the-flavonoid-quercetin-to-prevent-and-treat-cancer-current-status-of-research
#5
Neuwirthová Jana, Gál Břetislav, Smilek Pavel, Urbánková Pavla
Naturally occurring bioactive compounds are promising candidates to prevent and treat cancer. Quercetin is a well-known plant flavonoid that is reported to have anticancer actions in vitro and in vivo. This review focuses on the molecular mechanisms underlying the chemopreventive effect of quercetin and its therapeutic potential in oncology. Quercetin elicits biphasic, hormetic, dose-dependent effects. It acts as an antioxidant and thus elicits chemopreventive effects at low concentrations, but functions as a pro-oxidant and may therefore elicit chemotherapeutic effects at high concentrations...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/30441946/periodic-fevers-and-other-autoinflammatory-diseases
#6
Šárka Fingerhutová, Eva Jančová, Markéta Tesařová, Lenka Dvořáková, Pavla Doležalová
Autoinflammatory diseases represent a relatively new and rapidly evolving group of rare disorders associated with mutations of genes encoding proteins with a key regulatory role in inflammatory response. Gradual discovery of mechanisms that link genetic disorder with its biochemical and immunological consequences leading to continuous or episodic inflammatory stimulation has enabled introduction of directed immunotherapies. Periodic fever syndromes belong to the so far best-known entities: familial Mediterranean fever, mevalonate kinase deficiency, cryopyrinopathies and TNF-receptor associated periodic syndrome...
2018: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/30439628/rheumatic-immune-related-adverse-events-secondary-to-anti-programmed-death-1-antibodies-and-preliminary-analysis-on-the-impact-of-corticosteroids-on-anti-tumour-response-a-case-series
#7
Emma L Mitchell, Peter Kar Han Lau, Chloe Khoo, David Liew, Jessica Leung, Bonnia Liu, Adam Rischin, Albert G Frauman, Damien Kee, Kortnye Smith, Benjamin Brady, Danny Rischin, Andrew Gibson, Linda Mileshkin, Oliver Klein, Andrew Weickhardt, Surein Arulananda, Mark Shackleton, Grant McArthur, Andrew Östör, Jonathan Cebon, Benjamin Solomon, Russell Rc Buchanan, Ian P Wicks, Serigne Lo, Rodney J Hicks, Shahneen Sandhu
IMPORTANCE: Rheumatic immune-related adverse events (irAEs) occur in approximately 10-20% of anti-programmed death 1 (anti-PD1)-treated cancer patients. There are limited data on the natural history, optimal treatment and long-term oncological outcomes of patients with rheumatic irAEs. OBJECTIVE: The objective of the study was to describe the spectrum and natural history of rheumatic irAEs and the potential impact of rheumatic irAEs and immunomodulators on anti-PD1 tumour efficacy...
November 12, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/30439384/an-overview-of-the-neuroprotective-potential-of-rosmarinic-acid-and-its-association-with-nanotechnology-based-delivery-systems-a-novel-approach-to-treating-neurodegenerative-disorders
#8
Flávia Nathiely Silveira Fachel, Roselena Silvestri Schuh, Kleyton Santos Veras, Valquíria Linck Bassani, Letícia Scherer Koester, Amelia Teresinha Henriques, Elizandra Braganhol, Helder Ferreira Teixeira
Neurodegenerative disorders (ND) are characterized by slow and progressive neuronal dysfunction induced by the degeneration of neuronal cells in the central nervous system (CNS). Recently, the neuroprotective effects of natural compounds with anti-inflammatory and antioxidant activities has been clearly demonstrated. This appears to be an attractive therapeutic approach for ND, particularly regarding the use of polyphenols. In this review, we present an overview of the neuroprotective potential of rosmarinic acid (RA) and discuss the use of nanotechnology as a novel approach to treating ND...
November 12, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/30431378/severe-nonalcoholic-steatohepatitis-and-type-2-diabetes-liver-histology-after-weight-loss-therapy-in-a-randomized-clinical-trial
#9
Kuat Oshakbayev, Bakytzhan Bimbetov, Kenzhegul Manekenova, Gulnara Bedelbayeva, Khalit Mustafin, Bibazhar Dukenbayeva
OBJECTIVE: To evaluate the effectiveness of the fast weight loss method on liver steatosis, fibrosis, inflammation, glycemic and lipids features and body composition in patients with severe Nonalcoholic Steatohepatitis (NASH) and Type 2 Diabetes (T2D). METHODS: A 24-week open prospective randomised controlled clinical trial including 80 adult patients (aged 40-65 years) was performed. The patients after randomisation were divided in two groups: Main group followed the fast weight loss method; Control group received conventional drug treatment...
November 15, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30430126/detection-of-a-unicentric-type-of-castleman-like-mass-at-the-site-of-adrenal-grand-a-case-report-and-review-of-literature
#10
Jing Chen, Cheng Yang, Chao-Zhao Liang
We present a case of adrenal CD in a 26-year-old female. The patient was referred to our hospital because of left flank pain for 1 wk. A computed tomography scan revealed a 4 cm × 3 cm well-defined mass, considered as a paraganglioma. A preoperative diagnosis of left adrenal neoplasm and urinary tract infection was made. The patient underwent anti-inflammatory therapy followed by an open operation to remove the mass in the left adrenal. Through analysis of the morphological pattern and immunohistochemical markers, a diagnosis of CD was made...
November 6, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/30429880/sonodynamic-therapy-induced-foam-cells-apoptosis-activates-the-phagocytic-ppar%C3%AE-lxr%C3%AE-abca1-abcg1-pathway-and-promotes-cholesterol-efflux-in-advanced-plaque
#11
Huan Wang, Yang Yang, Xin Sun, Fang Tian, Shuyuan Guo, Wei Wang, Zhen Tian, Hong Jin, Zhiguo Zhang, Ye Tian
In advanced atherosclerotic plaques, defective efferocytosis of apoptotic foam cells and decreased cholesterol efflux contribute to lesion progression. In our previous study, we demonstrated that 5-aminolevulinic acid (ALA)-mediated sonodynamic therapy (SDT) could induce foam cells apoptosis via the mitochondrial-caspase pathway. In the current research, we sought to explore ALA-SDT-induced apoptosis of phagocytes and the effects of cholesterol efflux and efferocytosis in advanced apoE-/- mice plaque. Methods: apoE-/- mice fed western diet were treated with ALA-SDT and sacrificed at day 1, day 3, day 7 and day 28 post treatment...
2018: Theranostics
https://www.readbyqxmd.com/read/30429487/ntg-101-a-novel-molecular-therapy-that-halts-the-progression-of-degenerative-disc-disease
#12
Ajay Matta, Muhammad Zia Karim, Hoda Gerami, Peter Jun, Martha Funabashi, Greg Kawchuk, Alyssa Goldstein, Warren Foltz, Marshall Sussman, Bjorn C Eek, W Mark Erwin
The tremendous cost, pain and disability associated with degenerative disc disease (DDD) makes the development of a biological agent that can mitigate the course of DDD, a critical unmet need. We have identified and reported that a single injection of a combination of recombinant human (rh) Transforming growth factor beta 1 (TGF-β1) and Connective tissue growth factor (CTGF) proteins into the injured intervertebral disc (IVD) nucleus pulposus (NP) can mediate DDD in a pre-clinical rodent model. In this study, we developed and evaluated the efficacy of a novel molecular therapy (NTG-101) containing rhTGF-β1 and rhCTGF proteins suspended in an excipient solution using in vivo models of DDD including rat-tail and chondrodystrophic (CD) canines...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30428613/the-biological-efficacy-of-natural-products-against-acute-and-chronic-inflammatory-diseases-in-the-oral-region
#13
REVIEW
Toshiaki Ara, Sachie Nakatani, Kenji Kobata, Norio Sogawa, Chiharu Sogawa
The oral inflammatory diseases are divided into two types: acute and chronic inflammatory diseases. In this review, we summarize the biological efficacy of herbal medicine, natural products, and their active ingredients against acute and chronic inflammatory diseases in the oral region, especially stomatitis and periodontitis. We review the effects of herbal medicines and a biscoclaurin alkaloid preparation, cepharamthin, as a therapy against stomatitis, an acute inflammatory disease. We also summarize the effects of herbal medicines and natural products against periodontitis, a chronic inflammatory disease, and one of its clinical conditions, alveolar bone resorption...
November 13, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/30428588/from-friend-to-enemy-dissecting-the-functional-alteration-of-immunoregulatory-components-during-pancreatic-tumorigenesis
#14
REVIEW
Hui-Ching Wang, Wen-Chun Hung, Li-Tzong Chen, Mei-Ren Pan
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a 5-year survival rate of approximately 8%. More than 80% of patients are diagnosed at an unresectable stage due to metastases or local extension. Immune system reactivation in patients by immunotherapy may eliminate tumor cells and is a new strategy for cancer treatment. The anti-CTLA-4 antibody ipilimumab and anti-PD-1 antibodies pembrolizumab and nivolumab have been approved for cancer therapy in different countries. However, the results of immunotherapy on PDAC are unsatisfactory...
November 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30426851/the-effect-of-laminin-111-hydrogels-on-muscle-regeneration-in-a-murine-model-of-injury
#15
Madison Marcinczyk, Andrew J Dunn, Gabriel Haas, Josh Madsen, Robert Scheidt, Krishna Patel, Muhamed Talovic, Koyal Garg
Volumetric muscle loss (VML) is characterized by a critical loss of muscle tissue that is accompanied by severe functional impairment and often long-term disability. Clinical therapies currently employed in the treatment of VML are ineffective at regenerating lost muscle and restoring function. In this study, we used a novel hydrogel composed of fibrinogen and laminin-111, to promote regeneration and recovery of VML traumatized muscle. Our previous study showed that these hydrogels exhibit fibrous structure and Young's modulus of ~2kPa while supporting C2C12 myoblast proliferation, myogenic marker expression, and pro-regenerative growth factor secretion in vitro...
November 14, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/30426543/cepharanthine-suppresses-osteoclast-formation-by-modulating-the-nuclear-factor-%C3%AE%C2%BAb-and-nuclear-factor-of-activated-t-cell-signaling-pathways
#16
Xixi Lin, Fangming Song, Lin Zhou, Ziyi Wang, Chengming Wei, Jiake Xu, Jinmin Zhao, Qian Liu
The increased activation of osteoclasts is the major manifestation of several lytic bone diseases, including osteoporosis, rheumatoid arthritis, aseptic loosening of orthopedic implants, Paget disease and malignant bone diseases. One important bone-protective therapy in these diseases focuses on the inhibition of osteoclast differentiation and resorptive function. Given that the deleterious side-effects of currently available drugs, it is beneficial to search for effective and safe medications from natural compounds...
November 13, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30426454/losartan-suppresses-the-inflammatory-response-in-collagen-induced-arthritis-by-inhibiting-the-mapk-and-nf-%C3%AE%C2%BAb-pathways-in-b-and-t-cells
#17
Xinming Wang, Xiaoyun Chen, Wei Huang, Pengying Zhang, Yawei Guo, Heinrich Körner, Huaxun Wu, Wei Wei
The angiotensin II type 1 receptor (AT1R) antagonist losartan has been confirmed to have a moderate anti-inflammatory effect in vitro and in vivo. However, how it affects immune cells in Rheumatoid Arthritis (RA) is still unknown. We found that in human synovial tissues, AT1R is significantly expressed on T cells and B cells. Treatment with losartan (15 mg/kg) alone and in combination with a low dose of methotrexate (MTX 0.25 mg/kg/3 days) significantly suppressed the progression of CIA. Secondary paw swelling, joint destruction and the presence of pro-inflammatory cytokines (TNF-α and IFN-γ) in the serum were alleviated after treatment...
November 13, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/30426234/persistent-eosinophilia-in-rheumatoid-arthritis-a-prospective-observational-study
#18
Dantis Emmanuel, Subhash Chandra Parija, Ankit Jain, Durga Prasanna Misra, Rakhee Kar, Vir Singh Negi
Eosinophilia is an uncommon manifestation in Rheumatoid arthritis (RA), and there is a paucity of data regarding the relationship of eosinophilia with disease-related factors. We prospectively evaluated the clinical and disease-specific characteristics of RA patients with eosinophilia. Consecutive patients with RA with an absolute eosinophil count ≥ 500/mm3 without an apparent cause for eosinophilia, were investigated for parasitic infestation. Patients with a definite parasitic infestation received targeted therapy, and the rest were treated with albendazole empirically...
November 13, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30426218/effect-of-nonsteroidal-anti-inflammatory-drugs-in-children-with-bartter-syndrome
#19
Gaël Gasongo, Larry A Greenbaum, Olivier Niel, Theresa Kwon, Marie-Alice Macher, Anne Maisin, Véronique Baudouin, Claire Dossier, Georges Deschênes, Julien Hogan
BACKGROUND: Bartter syndrome (BS) is a salt-wasting tubulopathy with induced expression of cyclooxygenase-2 in the macula densa, leading to increased prostaglandin production and hyperreninemia. Nonsteroidal anti-inflammatory drugs (NSAIDs) are currently used in BS; however, there is limited information on the impact of NSAIDs at treatment initiation or the potential utility of plasma renin level to guide therapy in patients with BS. METHODS: We included 19 patients with BS treated with NSAIDs between 1994 and 2016...
November 13, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30425811/combination-of-diclofenac-and-aggressive-hydration-for-the-prevention-of-post-ercp-pancreatitis
#20
Mehri Hajalikhani, Mohammad Hassan Emami, Mahsa Khodadoostan, Ahmad Shavakhi, Moeen Rezaei, Reza Soluki
Aim: To investigate whether aggressive hydration can increase the efficacy of prophylactic non-steroid anti-inflammatory drugs (NSAIDs) in prevention of post-ERCP pancreatitis. Background: NSAIDs are recommended for the prevention of PEP; however, whether aggressive hydration can have additional benefits in this regard is not known. Methods: Patients candidate for ERCP received either pre-procedural rectal diclofenac (100 mg) alone (n = 112) or in combination with aggressive hydration by lactate ringer's (n = 107) as prophylactic method...
2018: Gastroenterology and Hepatology From Bed to Bench
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