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Anti- cytokine therapies

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https://www.readbyqxmd.com/read/30025404/involvement-of-advanced-glycation-end-products-in-the-pathogenesis-of-diabetic-retinopathy
#1
Jing Xu, Lin-Jiang Chen, Jian Yu, Han-Jing Wang, Fan Zhang, Qiong Liu, Jing Wu
Diabetic retinopathy (DR) is a common and devastating microvascular complication of diabetes and a major cause of acquired blindness in young adults. Advanced glycation end products (AGEs) accumulated under hyperglycemic conditions are thought to play an important role in the pathogenesis of DR. AGEs can exert their deleterious effects by acting directly to induce aberrant crosslinking of extracellular matrix proteins, to increase vascular stiffness, altering vascular structure and function. Moreover, AGEs binding to the receptor for AGEs (RAGE) evokes intensive intracellular signaling cascades that leading to endothelial dysfunction, elaboration of key proinflammatory cytokines and proangiogenic factors, mediating pericyte apoptosis, vascular inflammation and angiogenesis, as well as breakdown of the inner blood-retinal barrier (BRB), the end result of all these events is damage to the neural and vascular components of the retina...
July 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30024982/therapeutic-effects-of-recombinant-human-interleukin-2-as-adjunctive-immunotherapy-against-tuberculosis-a-systematic-review-and-meta-analysis
#2
Ruimei Zhang, Xiangyu Xi, Chunying Wang, Yong Pan, Changhua Ge, Liying Zhang, Shuo Zhang, Huimei Liu
BACKGROUND: Interleukin 2 (IL-2) is a cytokine secreted by activated T cells. Studies exploring recombinant human interleukin 2 (rhuIL-2) as an adjunctive immunotherapeutic agent to treat tuberculosis (TB) have shown variable results; however, the true therapeutic efficacy of rhuIL-2 administration in TB patients has not been determined. METHODS: A systematic review to identify publications exploring the association between rhuIL-2-based immunotherapy for TB and outcomes (sputum culture conversion, sputum smear conversion, radiographic changes, and leukocyte phenotype changes) in patients with pulmonary TB published before June 8, 2018 was performed...
2018: PloS One
https://www.readbyqxmd.com/read/30024302/advances-in-understanding-the-role-of-cytokines-in-inflammatory-bowel-disease
#3
Gerolamo Bevivino, Giovanni Monteleone
Cytokines represent the key pathophysiologic elements that govern the initiation, progression and, in some circumstances, the resolution of the inflammation occurring in inflammatory bowel disease (IBD). Areas covered: In this review, we will focus on the main effector and anti-inflammatory cytokines produced in IBD and discuss the results of recent trials in which cytokine-based therapy has been used for treating IBD patients. Expert commentary: The possibility to sample mucosal biopsies from IBD patients and analyze which molecular pathways are prominent during the active phases of the disease and the easy access to various models of experimental colitis have largely advanced our understanding about the role of cytokines in IBD...
July 19, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30023361/pooled-platelet-rich-plasma-lysate-therapy-increases-synoviocyte-proliferation-and-hyaluronic-acid-production-while-protecting-chondrocytes-from-synoviocyte-derived-inflammatory-mediators
#4
Jessica M Gilbertie, Julie M Long, Alicia G Schubert, Alix K Berglund, Thomas P Schaer, Lauren V Schnabel
Platelet-rich plasma (PRP) preparations are being used with moderate success to treat osteoarthritis (OA) in humans and in veterinary species. Such preparations are hindered, however, by being autologous in nature and subject to tremendous patient and processing variability. For this reason, there has been increasing interest in the use of platelet lysate preparations instead of traditional PRP. Platelet lysate preparations are acellular, thereby reducing concerns over immunogenicity, and contain high concentrations of growth factors and cytokines...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/30021624/bone-marrow-derived-mesenchymal-stem-cells-ameliorate-inflammatory-response-in-an-in-vitro-model-of-familial-hemophagocytic-lymphohistiocytosis-2
#5
Handan Sevim, Yusuf Çetin Kocaefe, Mehmet Ali Onur, Duygu Uçkan-Çetinkaya, Özer Aylin Gürpınar
BACKGROUND: Familial hemophagocytic lymphohistiocytosis 2 (FHL2) is the most common familial type of hemophagocytic lymphohistiocytosis with immune dysregulation. FHL2 patients have mutations in the perforin gene which cause overactivation and proliferation of cytotoxic T lymphocytes and natural killer cells. Perforin is the key component of the cytolytic granule response function of cytotoxic T lymphocytes and natural killer cells. Perforin dysfunction causes a cytotoxic immune deficiency with a clinical outcome of uncontrolled and continuous immune stimulation response...
July 18, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30019185/cathepsin-b-inhibition-ameliorates-the-non-alcoholic-steatohepatitis-through-suppressing-caspase-1-activation
#6
Yong Tang, Guojun Cao, Xiaobo Min, Tao Wang, Shiran Sun, Xiaolong Du, Weikang Zhang
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease. NLRP3 inflammasome activation has been widely studied in the pathogenesis of NAFLD. Cathepsin B (CTSB) is a ubiquitous cysteine cathepsin, and the role of CTSB in the progression and development of NAFLD has received extensive concern. However, the exact roles of CTSB in the NAFLD development and NLRP3 inflammasome activation are yet to be evaluated. In the present study, we used methionine choline-deficient (MCD) diet to establish mice NASH model...
July 17, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30017723/therapeutic-effect-of-vitamin-d-3-containing-nanostructured-lipid-carriers-on-inflammatory-bowel-disease
#7
Khadijah Zai, Masato Hirota, Takahiro Yamada, Narumi Ishihara, Takeshi Mori, Akihiro Kishimura, Koichiro Suzuki, Koji Hase, Yoshiki Katayama
The active form of vitamin D3 , 1,25(OH)2 D3 has been found to exert multiple effects on the suppression of progression of inflammatory bowel disease (IBD). Vitamin D3 has been gathering attention as a therapy for IBD. However, the clinical trials conducted to date revealed that a relatively high dosage of vitamin D3 was required to see a significant therapeutic effect. Thus, effective formulation and delivery of vitamin D3 to colonic inflammatory lesions will be required. Herein we describe the preparation of a nanostructured lipid carrier (NLC) for the encapsulation of 1,25(OH)2 D3 for colonic delivery via oral administration...
July 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30017519/anti-tnf-modulation-reduces-myocardial-inflammation-and-improves-cardiovascular-function-in-systemic-rheumatic-diseases
#8
Ntobeko A B Ntusi, Jane M Francis, Emily Sever, Alexander Liu, Stefan K Piechnik, Vanessa M Ferreira, Paul M Matthews, Matthew D Robson, Paul B Wordsworth, Stefan Neubauer, Theodoros D Karamitsos
BACKGROUND: Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are common disorders associated with increased rates of cardiovascular disease (CVD), but the contribution of cytokine-induced inflammation to impaired cardiovascular function in these conditions remains poorly understood. OBJECTIVES: We assessed the effect of anti-TNF therapy on myocardial and vascular function, myocardial tissue characteristics and perfusion in inflammatory arthropathy and systemic rheumatic disease (IASRD) patients, using cardiovascular magnetic resonance (CMR)...
June 25, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30015238/sauchinone-inhibits-il-1%C3%AE-induced-catabolism-and-hypertrophy-in-mouse-chondrocytes-to-attenuate-osteoarthritis-via-nrf2-ho-1-and-nf-%C3%AE%C2%BAb-pathways
#9
Dengying Wu, ShanShan Jin, Zeng Lin, Rong Chen, Tianlong Pan, Xiaodiao Kang, Huasong Huang, Cong Lin, Jun Pan
BACKGROUND: Osteoarthritis (OA) is a common degenerative joint disease for which currently no anti-inflammatory therapy is available. Sauchinone (SAU), a key bioactive compound derived from Saururus chinensis, which has shown remarkable anti-inflammatory effects. METHODS: To evaluate the effect of SAU on OA progression, mouse chondrocytes were pretreated with SAU and subsequently stimulated with interleukin (IL)-1β. We found that SAU reduced the production of pro-inflammatory cytokines, such as nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α), and IL-6...
July 13, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30014800/metallothionein-a-novel-therapeutic-target-for-treatment-of-inflammatory-bowel-disease
#10
Kristen E Dostie, Amy V Thees, Michael A Lynes
Inflammatory bowel disease (IBD) is a group of disorders characterized by chronic inflammation within the gastrointestinal tract. It is a multifactorial disease associated with immune-cell mediated oxidative damage to the intestinal mucosa. There is no cure for IBD, but anti-cytokine therapy can limit target inflammation and disease progression. Unfortunately, many patients are nonresponsive or develop resistance to anti-cytokine therapy over time creating a need for new therapeutic agents. Metallothionein (MT) is a small, highly conserved stress response protein that has been shown to modulate the immune response as a pro-inflammatory agent, regulate divalent heavy metal homeostasis, and act as a reactive metabolite scavenger...
July 16, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/30014710/lactobacillus-acidophilus-and-clostridium-butyricum-ameliorate-colitis-in-murine-by-strengthening-the-gut-barrier-function-and-decreasing-inflammatory-factors
#11
Y Wang, Y Gu, K Fang, K Mao, J Dou, H Fan, C Zhou, H Wang
Ulcerative colitis is a type of chronic inflammation present in the intestines for which the aetiology is not yet clear. The current therapies for ulcerative colitis cannot be considered to be long-term management strategies due to their significant side effects. Therefore, it is essential to identify an alternative therapeutic strategy for ulcerative colitis. The present study focused on the evaluation of the anti-inflammatory activities of Lactobacillus acidophilus CGMCC 7282 and Clostridium butyricum CGMCC 7281...
July 17, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/30012672/activation-of-nkt-cells-in-an-anti-pd-1-resistant-tumor-model-enhances-anti-tumor-immunity-by-reinvigorating-exhausted-cd8-t-cells
#12
Eun-Ah Bae, Hyungseok Seo, Byung-Seok Kim, Jeongwon Choi, Insu Jeon, Kwang-Soo Shin, Choong-Hyun Koh, Boyeong Song, Il-Kyu Kim, Byung Soh Min, Yoon Dae Han, Sang Joon Shin, Chang-Yuil Kang
PD-1-based cancer immunotherapy is a successful example of immune checkpoint blockade that provides long-term durable therapeutic effects in cancer patients across a wide spectrum of cancer types. Accumulating evidence suggests that anti-PD-1 therapy enhances anti-tumor immunity by reversing the function of exhausted T cells in the tumor environment. However, the responsiveness rate of cancer patients to anti-PD-1 therapy remains low, providing an urgent need for optimization and improvement. In this study, we designed an anti-PD-1-resistant mouse tumor model and showed that unresponsiveness to anti-PD-1 is associated with a gradual increase in CD8 T cell exhaustion...
July 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/30012511/preterm-umbilical-cord-blood-derived-mesenchymal-stem-stromal-cells-protect-preterm-white-matter-brain-development-against-hypoxia-ischemia
#13
Jingang Li, Tamara Yawno, Amy E Sutherland, Shanti Gurung, Madison Paton, Courtney McDonald, Abhilasha Tiwari, Yen Pham, Margie Castillo-Melendez, Graham Jenkin, Suzanne L Miller
INTRODUCTION: Preterm infants are at high risk for white matter injury and subsequent neurodevelopmental impairments. Mesenchymal stem/stromal cells (MSC) have anti-inflammatory/immunomodulatory actions and are of interest for neural repair in adults and newborns. This study examined the neuroprotective effects of allogeneic MSC, derived from preterm umbilical cord blood (UCB), in a preterm sheep model of white matter injury. METHODS: Quad-lineage differentiation, clonogenicity and self-renewal ability of UCB-derived MSC were confirmed...
July 13, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/30011893/application-of-spray-drying-particle-engineering-to-a-high-functionality-low-solubility-milk-thistle-extract-powders-production-and-characterization
#14
Francesca Sansone, Tiziana Esposito, Maria Rosaria Lauro, Patrizia Picerno, Teresa Mencherini, Franco Gasparri, Stefania De Santis, Marcello Chieppa, Claudia Cirillo, Rita Patrizia Aquino
Many natural compounds having antioxidant and anti-inflammatory activity are a potential target for new therapies against chronic inflammatory syndromes. The oral administration of functional herbal supplements may become a prevention strategy or therapy adjuvant for susceptible patients. A case study is our milk thistle ( Silybum marianum ) extract rich in silymarin complex. A water-soluble microencapsulated powder system was developed by a spray drying technique to improve the poor silymarin bioactivity after oral administration...
July 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30005856/inflammation-and-dementia-using-rheumatoid-arthritis-as-a-model-to-develop-treatments
#15
REVIEW
Alice Mason, Clive Holmes, Christopher J Edwards
Dementia is a major international public health problem which looks set to grow as the ageing population increases. Despite large amounts of investment there has been relatively little progress in developing new therapies to combat this. There is a growing body of evidence that both local and systemic inflammation are important in dementia; with cerebral inflammation occurring secondarily to beta-amyloid plaques, raised levels of serum inflammatory molecules and cytokines being present in Alzheimer's disease patients and systemic inflammation being associated with cerebral microvasculature disease in vascular dementia...
July 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30005742/role-of-microglia-m1-m2-polarisation-in-the-paraventricular-nucleus-new-insight-into-the-development-of-stress-induced-hypertension-in-rats
#16
Yang Mi, Qin Wu, Wanru Yuan, Fuxue Chen, Dongshu Du
The lack of precise therapies for stress-induced hypertension highlights the need to explore the process of blood pressure changes. Studies have shown that neuroinflammation in the central nervous system is associated with hypertension, although the mechanisms remain elusive. Microglia, are known to play dualistic protective and destructive roles, representing logical but challenging targets for improving stress-induced hypertension. Here, as a model, we used rats with stress-induced hypertension, and found that a switch from an immunoregulatory (M2) to a pro-inflammatory (M1) dominant response occurred in microglia during development of stress-induced hypertension...
September 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/30005593/phospholipase-c%C3%AE-2-is-critical-for-ca-2-flux-and-cytokine-production-in-anti-fungal-innate-immunity-of-human-corneal-epithelial-cells
#17
Xudong Peng, Guiqiu Zhao, Jing Lin, Jianqiu Qu, Yingxue Zhang, Cui Li
BACKGROUND: Fungal keratitis (FK) is a sight-threatening disease, accounting for a significant portion with its complex presentation, suboptimal efficacy of the existing therapies and uncontrollable excessive innate inflammation. Phospholipase C-γ2 (PLCγ2) is a non-receptor tyrosine kinase that plays an important role at the early period of innate immunity. This study aimed to identify the role of PLCγ2 in Dectin-1-mediated Ca2+ Flux and its effect on the expression of proinflammatory mediators at the exposure to Aspergillus fumigatus (A...
July 13, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/30005227/anti-inflammatory-properties-of-cilostazol-its-interruption-of-dna-binding-activity-of-nf-%C3%AE%C2%BAb-from-the-toll-like-receptor-signaling-pathways
#18
Takuya Sakamoto, Wakana Ohashi, Kengo Tomita, Kohshi Hattori, Naoyuki Matsuda, Yuichi Hattori
Cilostazol, a selective inhibitor of phosphodiesterase type III with anti-platelet, anti-mitogenic, and vasodilating properties, is widely used to treat ischemic symptoms of peripheral vascular disease. Ample evidence has suggested that cilostazol also exhibits an anti-inflammatory effect, but its anti-inflammatory mechanism is not fully understood. Here, we showed that cilostazol specifically inhibited expression of cytokines, which are induced by nuclear factor-κB (NF-κB) activation, in RAW264.7 macrophage cells stimulated with different Toll-like receptor (TLR) ligands...
July 10, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30003810/antioxidant-effects-of-vitamin-d-on-lacrimal-glands-against-high-dose-radioiodine-associated-damage-in-an-animal-model
#19
Umit Eksioglu, Hasan Ikbal Atilgan, Mehmet Yakin, Nuray Yazihan, Ugur Emrah Altiparmak, Nihat Yumusak, Meliha Korkmaz, Ayten Demir, Firdevs Ornek, Pelin Aribal Ayral, Gokhan Koca
PURPOSE: To evaluate antioxidant effects of active vitamin D (calcitriol) against high-dose radioiodine (RAI) therapy-associated damage of lacrimal gland. MATERIALS AND METHODS: Wistar albino rats were used and divided into three groups randomly (n = 12/group). The first group was appointed as the negative control group and received no RAI or medication. The second group was appointed as the positive control group that only received 3 mCi/kg (111 MBq/kg) RAI via gastric gavage and the last group was the treatment group that received 3 mCi/kg RAI via same method and calcitriol (200 ng/kg/day) via intraperitoneal administration...
July 13, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/30001416/azithromycin-therapy-reduces-cardiac-inflammation-and-mitigates-adverse-cardiac-remodeling-after-myocardial-infarction-potential-therapeutic-targets-in-ischemic-heart-disease
#20
Ahmed Al-Darraji, Dalia Haydar, Lakshman Chelvarajan, Himi Tripathi, Bryana Levitan, Erhe Gao, Vincent J Venditto, John C Gensel, David J Feola, Ahmed Abdel-Latif
INTRODUCTION: Acute myocardial infarction (MI) is a primary cause of worldwide morbidity and mortality. Macrophages are fundamental components of post-MI inflammation. Pro-inflammatory macrophages can lead to adverse cardiac remodeling and heart failure while anti-inflammatory/reparative macrophages enhance tissue healing. Shifting the balance between pro-inflammatory and reparative macrophages post-MI is a novel therapeutic strategy. Azithromycin (AZM), a commonly used macrolide antibiotic, polarizes macrophages towards the anti-inflammatory phenotype, as shown in animal and human studies...
2018: PloS One
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