keyword
https://read.qxmd.com/read/38536671/evaluating-a-promising-methylcellulose-hydrogel-for-enhanced-diabetic-foot-ulcer-therapy-through-comprehensive-preclinical-studies
#1
JOURNAL ARTICLE
Priya Patel, Sanika Dongre, Alkesh Patel, Gayatri Patel
The present research focuses on formulating and evaluating hydrogels modified with crosslinking agents using methylcellulose to treat diabetic foot ulcers (DFU). Methylcellulose hydrogels are prepared and characterized for their crosslinking capacity through FTIR and degradation studies. The optimized hydrogel is further assessed for viscosity, gel strength, contact angle, in-vitro biodegradation, water-vapor transmission rate, anti-bacterial activity, and in-vivo efficacy. The results demonstrate that the developed hydrogel exhibits promising properties for DFU treatment, including increased wound healing percentage, improved ulcer morphology, reduced levels of proinflammatory cytokines, and enhanced tissue characteristics...
March 27, 2024: Journal of Biomaterials Science. Polymer Edition
https://read.qxmd.com/read/38533498/disease-associated-immune-cell-endotypes-in-anti-mda5-positive-dermatomyositis-using-unbiased-hierarchical-clustering
#2
JOURNAL ARTICLE
Ruru Guo, Yang Yang, Liyang Gu, Xinyu Li, Yiyangzi Ma, Xuesong Liu, Liangjing Lu
OBJECTIVE: Clinical and prognostic features of Anti-MDA5-Positive Dermatomyositis (MDA5+ DM) are diverse. This study aimed to examine the peripheral immune cell profiles of patients with MDA5+ DM, identify disease endotypes related to the heterogeneous manifestations and prognosis, and guide individualized therapy regimen. METHODS: This inpatient cohort included 123 patients with MDA5+ DM. Unsupervised hierarchical clustering analysis was used to derive disease endotypes from the circulating immune cell profiles on admission...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38532629/need-for-standardization-of-cytokine-profiling-in-car-t-cell-therapy
#3
JOURNAL ARTICLE
D Nathan Biery, David P Turicek, Caroline Diorio, Brett A Schroeder, Nirali N Shah
With expansion of CAR T-cell therapy and broader utilization of anti-cytokine directed therapeutics for toxicity mitigation, the routine assessment of cytokines may enhance understanding of toxicity profiles, guide therapeutic interventions, and facilitate cross-trial comparisons. As specific cytokine elevations can correlate with and provide insights into CAR T-cell toxicity, mitigation strategies, and response, we explored the reporting of cytokine detection methods and assessed for the correlation of cytokines to CRS and ICANS across clinical trials...
March 25, 2024: Molecular Therapy
https://read.qxmd.com/read/38530888/normalizing-granuloma-vasculature-and-matrix-improves-drug-delivery-and-reduces-bacterial-burden-in-tuberculosis-infected-rabbits
#4
JOURNAL ARTICLE
Meenal Datta, Laura E Via, Véronique Dartois, Danielle M Weiner, Matthew Zimmerman, Firat Kaya, April M Walker, Joel D Fleegle, Isaac D Raplee, Colton McNinch, Maksym Zarodniuk, Walid S Kamoun, Changli Yue, Ashwin S Kumar, Sonu Subudhi, Lei Xu, Clifton E Barry, Rakesh K Jain
Host-directed therapies (HDTs) represent an emerging approach for bacterial clearance during tuberculosis (TB) infection. While most HDTs are designed and implemented for immuno-modulation, other host targets-such as nonimmune stromal components found in pulmonary granulomas-may prove equally viable. Building on our previous work characterizing and normalizing the aberrant granuloma-associated vasculature, here we demonstrate that FDA-approved therapies (bevacizumab and losartan, respectively) can be repurposed as HDTs to normalize blood vessels and extracellular matrix (ECM), improve drug delivery, and reduce bacterial loads in TB granulomas...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38530131/precision-delivery-of-human-bone-marrow-derived-mesenchymal-stem-cells-into-the-pancreas-via-intra-arterial-injection-prevents-the-onset-of-diabetes
#5
JOURNAL ARTICLE
Rosita Primavera, Shobha Regmi, Reza Yarani, Steven Levitte, Jing Wang, Abantika Ganguly, Shashank Chetty, Michele Guindani, Camillo Ricordi, Everett Meyer, Avnesh S Thakor
Mesenchymal stem cells (MSCs) are a promising therapy to potentially treat diabetes given their potent anti-inflammatory and immune-modulatory properties. While these regenerative cells have shown considerable promise in cell culture, their clinical translation has been challenging. In part, this can be attributed to these cells not reaching the pancreas to exert their regenerative effects following conventional intravenous (IV) injection, with the majority of cells being trapped in the lungs in the pulmonary first-pass effect...
March 26, 2024: Stem Cells Translational Medicine
https://read.qxmd.com/read/38529271/the-role-of-immune-cells-and-inflammation-in-pulmonary-hypertension-mechanisms-and-implications
#6
REVIEW
Hui Zhao, Jialin Song, Xiujun Li, Zhaoyi Xia, Qian Wang, Jiaqi Fu, Yuqing Miao, Dapeng Wang, Xuguang Wang
Pulmonary hypertension (PH) is a malignant disease with progressive increase of pulmonary vascular pressure, which eventually leads to right heart failure. More and more evidences show that immune cells and inflammation play an important role in the occurrence and development of PH. In the context of pulmonary vascular diseases, immune cells migrate into the walls of the pulmonary vascular system. This leads to an increase in the levels of cytokines and chemokines in both the bloodstream and the surrounding tissues of the pulmonary vessels...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38528553/extracorporeal-photopheresis-reduces-inflammation-and-joint-damage-in-a-rheumatoid-arthritis-murine-model
#7
JOURNAL ARTICLE
Yuwei Lin, Zhanrui Cheng, Yan Zhong, Yinting Zhao, Guifen Xiang, Ling Li, Li Tian, Zhong Liu
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammatory reactions and tissue damage in the joints. Long-term drug use in clinical practice is often accompanied by adverse reactions. Extracorporeal photopheresis (ECP) is an immunomodulatory therapy with few side effects, offering a potential and safe therapeutic alternative for RA through the induction of immune tolerance. This study aimed to investigate the therapeutic effects of ECP on RA using a collagen-induced arthritis (CIA) murine model, as well as to explore its immunomodulatory effects in vivo...
March 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38527764/inhibition-of-jak-stat-pathway-corrects-salivary-gland-inflammation-and-interferon-driven-immune-activation-in-sj%C3%A3-gren-s-disease
#8
JOURNAL ARTICLE
Sarthak Gupta, Eiko Yamada, Hiroyuki Nakamura, Paola Perez, Thomas Jf Pranzatelli, Kalie Dominick, Shyh-Ing Jang, Mehdi Abed, Daniel Martin, Peter Burbelo, ChangYu Zheng, Ben French, Ilias Alevizos, Zohreh Khavandgar, Margaret Beach, Eileen Pelayo, Brian Walitt, Sarfaraz Hasni, Mariana J Kaplan, Mayank Tandon, Maria Teresa Magone, David E Kleiner, John A Chiorini, Alan Baer, Blake M Warner
OBJECTIVES: Inflammatory cytokines that signal through the Janus kinases-signal transducer and activator of transcription (JAK-STAT) pathway, especially interferons (IFNs), are implicated in Sjögren's disease (SjD). Although inhibition of JAKs is effective in other autoimmune diseases, a systematic investigation of IFN-JAK-STAT signalling and the effect of JAK inhibitor (JAKi) therapy in SjD-affected human tissues has not been fully investigated. METHODS: Human minor salivary glands (MSGs) and peripheral blood mononuclear cells (PBMCs) were investigated using bulk or single-cell (sc) RNA sequencing (RNAseq), immunofluorescence (IF) microscopy and flow cytometry...
March 25, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38526937/progesterone-induces-neuroprotection-associated-with-immune-inflammatory-modulation-in-experimental-traumatic-brain-injury
#9
JOURNAL ARTICLE
Ziwei Zhou, Yadan Li, Ruilong Peng, Mingming Shi, Weiwei Gao, Ping Lei, Jianning Zhang
An imbalance of immune/inflammatory reactions aggravates secondary brain injury after traumatic brain injury (TBI) and can deteriorate clinical prognosis. So far, not enough therapeutic avenues have been found to prevent such an imbalance in the clinical setting. Progesterone has been shown to regulate immune/inflammatory reactions in many diseases and conveys a potential protective role in TBI. This study was designed to investigate the neuroprotective effects of progesterone associated with immune/inflammatory modulation in experimental TBI...
March 1, 2024: Neuroreport
https://read.qxmd.com/read/38526073/preventive-nasal-administration-of-flagellin-restores-antimicrobial-effect-of-gentamicin-and-protects-against-a-multidrug-resistant-strain-of-pseudomonas-aeruginosa
#10
JOURNAL ARTICLE
Ana Raquel Maia, Adeline Cezard, Delphine Fouquenet, Virginie Vasseur, Benoit Briard, Jean-Claude Sirard, Mustapha Si-Tahar, Virginie Hervé
The increasing prevalence of multidrug-resistant Pseudomonas aeruginosa (PA) is a significant concern for chronic respiratory disease exacerbations. Host-directed drugs, such as flagellin, an agonist of toll-like receptor 5 (TLR5), have emerged as a promising solution. In this study, we evaluated the prophylactic intranasal administration of flagellin against a multidrug-resistant strain of PA (PAMDR ) in mice and assessed the possible synergy with the antibiotic gentamicin (GNT). The results indicated that flagellin treatment before infection decreased bacterial load in the lungs, likely due to an increase in neutrophil recruitment, and reduced signs of inflammation, including proinflammatory cytokines...
March 25, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38525262/the-amelioration-effect-of-antidiabetic-agents-on-cytokine-expression-in-patients-with-type-2-diabetes-mellitus
#11
JOURNAL ARTICLE
Abeer M Abd El-Hameed, Areej A Eskandrani, Eman Salah Abdel-Reheim, Adel Abdel Moneim, Wessam Addaleel
Inflammation is a condition that is closely linked to diabetes mellitus type 2 (T2DM), short for T2DM several different antidiabetic medications have been produced to regulate hyperglycemia, with indications that these therapies may have anti-inflammatory effects along with their glucose-lowering efficacy. Thus, this research was planned to explore the impact of antidiabetic agents on the cytokine expression levels -interleukin (IL)-1β, IL-6, IL-17, and IL-37 when patients have T2DM. In this study, 168 eligible subject matter was split into two groups: 50 healthy individuals and 118 cases with T2DM, who were classified into two subgroups: 30 untreated patients and 88 patients treated with metformin-based therapy...
May 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38524099/tezepelumab-for-severe-asthma-one-drug-targeting-multiple-disease-pathways-and-patient-types
#12
REVIEW
Reynold Panettieri, Njira Lugogo, Jonathan Corren, Christopher S Ambrose
Asthma is a heterogeneous inflammatory disease of the airways, affecting many children, adolescents, and adults worldwide. Up to 10% of people with asthma have severe disease, associated with a higher risk of hospitalizations, greater healthcare costs, and poorer outcomes. Patients with severe asthma generally require high-dose inhaled corticosteroids and additional controller medications to achieve disease control; however, many patients remain uncontrolled despite this intensive treatment. The treatment of severe uncontrolled asthma has improved with greater understanding of asthma pathways and phenotypes as well as the advent of targeted biologic therapies...
2024: Journal of Asthma and Allergy
https://read.qxmd.com/read/38522817/extracellular-vesicles-derived-from-dendritic-cells-loaded-with-vegf-a-sirna-and-doxorubicin-reduce-glioma-angiogenesis-in-vitro
#13
JOURNAL ARTICLE
Parisa Shamshiripour, Mehrana Rahnama, Mehdi Nikoobakht, Vahideh Farzam Rad, Ali-Reza Moradi, Davoud Ahmadvand
BACKGROUND: Numerous attempts have been devoted to designing anti-angiogenic agents as a strategy to slow tumor growth and progression. Clinical applications of conventional anti-angiogenic agents face some challenges, e.g., off-target effects for TKIs and also low solid tumor penetration for mAbs. Furthermore, although anti-angiogenic therapy provides a normalization window for better chemo-RT response, in long-term treatments, tumor hypoxia as a result of total removal of VEGF-A by mAbs from the TME or complete blockade of TK receptors induces over-activation of compensatory angiogenic pathways, causing escape...
March 22, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38522640/in-vitro-and-vivo-anti-tumor-activity-and-mechanisms-of-the-new-cryptotanshinone-derivative-11-against-hepatocellular-carcinoma
#14
JOURNAL ARTICLE
Xinni Yang, Xianlan She, Zhishuang Zhao, Jian Ren, Peiying Wang, Haoqi Dong, Qin-Shi Zhao, Jiangxin Liu
Global burden of hepatocellular carcinoma (HCC) is increasing. Chemotherapy and immunotherapy are the prevailing options for therapy. Developing new therapeutic strategies for HCC patients is still highly desirable. Recent studies demonstrate that cryptotanshinone is capable of inhibiting tumor growth in HCC and induces antitumor immunity in vitro. In our previous research, we discovered a new cryptotanshinone derivative 11 as an effective immunoregulatory enzyme indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor...
March 22, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38522625/effects-of-tibetan-medicine-longdan-zhike-tablet-on-chronic-obstructive-pulmonary-disease-through-mapk-pathway
#15
JOURNAL ARTICLE
Yulin Feng, Pengfei Qin, Rong Wang, Yahui Mi, You Li, Jiahao Feng, Wenbin Shen, Haijuan Dong, Jietai Duo, Liming Ma, Xiaowu Yao, Xiaolong Hu, Fei Xiong, Xinhong Shi, Hao Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Longdan zhike tablet (LDZK) is a Tibetan medicine formula commonly used in the highland region of Tibet, China, to ameliorate respiratory diseases, such as acute bronchitis and asthma. In Chinese traditional medicine, some herbal formulas with anti-inflammatory properties targeting the respiratory system are clinically adopted as supplementary therapies for chronic obstructive pulmonary disease (COPD). However, the specific anti-COPD effects of LDZK remain to be evaluated...
March 22, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38522155/leishmania-and-hiv-co-infection-first-naturally-leishmania-strain-presenting-decreased-susceptibility-to-miltefosine-recovered-from-a-patient-in-portugal
#16
JOURNAL ARTICLE
Ana Isabel Pinto, Cátia Caldas, Nuno Santarém, Sara Luelmo, Inês Costa, Carlos Martins, Ricardo Monteiro, Sílvia Conde, Raquel Tavares, Anabela Cordeiro da Silva
BACKGROUND: In Europe, up to 70% of visceral leishmaniasis (VL) cases occurring in adults living with HIV. People living with HIV with VL co-infection often display persistent parasitemia, requiring chronic intermittent anti-Leishmania therapies. Consequently, frequent VL relapses and higher mortality rates are common in these individuals. As such, it is of paramount importance to understand the reasons for parasite persistence to improve infection management. METHODS: To outline possible causes for treatment failure in the context of HIV-VL, we followed a person living with HIV-VL co-infection for nine years in a 12-month period...
March 13, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38521924/an-in-vitro-study-elucidating-the-synergistic-effects-of-aqueous-cinnamon-extract-and-an-anti-tnf-%C3%AE-biotherapeutic-implications-for-a-complementary-and-alternative-therapy-for-non-responders
#17
JOURNAL ARTICLE
Shubrata Khedkar, Minhaj Ahmad Khan
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) is a critical pro-inflammatory cytokine, and its abnormal production is associated with several immune mediated inflammatory diseases (IMID). Biological anti-TNF-α therapy includes treatment with monoclonal antibodies such as infliximab which have proven successful and are well-tolerated in most patients. Unfortunately, some patients may not respond to therapy (primary non-responders) or may lose sensitivity to the biological agent over time (early and late secondary non-responders)...
March 23, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38521764/prior-infection-with-unrelated-neurotropic-virus-exacerbates-influenza-disease-and-impairs-lung-t-cell-responses
#18
JOURNAL ARTICLE
Isabelle Jia-Hui Foo, Brendon Y Chua, E Bridie Clemens, So Young Chang, Xiaoxiao Jia, Hayley A McQuilten, Ashley Huey Yiing Yap, Aira F Cabug, Mitra Ashayeripanah, Hamish E G McWilliam, Jose A Villadangos, Maximilien Evrard, Laura K Mackay, Linda M Wakim, John K Fazakerley, Katherine Kedzierska, Lukasz Kedzierski
Immunity to infectious diseases is predominantly studied by measuring immune responses towards a single pathogen, although co-infections are common. In-depth mechanisms on how co-infections impact anti-viral immunity are lacking, but are highly relevant to treatment and prevention. We established a mouse model of co-infection with unrelated viruses, influenza A (IAV) and Semliki Forest virus (SFV), causing disease in different organ systems. SFV infection eight days before IAV infection results in prolonged IAV replication, elevated cytokine/chemokine levels and exacerbated lung pathology...
March 23, 2024: Nature Communications
https://read.qxmd.com/read/38521643/a-review-of-host-specific-diagnostic-and-surrogate-biomarkers-in-children-with-pulmonary-tuberculosis
#19
REVIEW
Junaid Shaik, Manormoney Pillay, Prakash Jeena
BACKGROUND: Tuberculosis (TB) is one of the most common causes of mortality globally with a steady rise in paediatric cases in the past decade. Laboratory methods of diagnosing TB and monitoring response to treatment have limitations. Current research focuses on interrogating host- and/or pathogen-specific biomarkers to address this problem. METHODS: We reviewed the literature on host-specific biomarkers in TB to determine their value in diagnosis and treatment response in TB infected and HIV/TB co-infected children on anti-tuberculosis treatment...
February 17, 2024: Paediatric Respiratory Reviews
https://read.qxmd.com/read/38520787/deciphering-jak-stat-signaling-pathway-a-multifaceted-approach-to-tumorigenesis-progression-and-therapeutic-interventions
#20
REVIEW
Yihui Wang, Zhe Wang, Shuyu Li, Juntao Ma, Xiaoshuo Dai, Jing Lu
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, essential for cellular communication, orchestrates a myriad of physiological and pathological processes. Recently, the intricate association between the pathway's dysregulation and the progression of malignant tumors has garnered increasing attention. Nevertheless, there is no systematic summary detailing the anticancer effects of molecules targeting the JAK/STAT pathway in the context of tumor progression. This review offers a comprehensive overview of pharmaceutical agents targeting the JAK/STAT pathway, encompassing phytochemicals, synthetic drugs, and biomolecules...
March 22, 2024: International Immunopharmacology
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