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Ciclosporin or cyclosporine, dog or canine

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https://www.readbyqxmd.com/read/28535337/overall-structural-model-of-ns5a-protein-from-hepatitis-c-virus-and-modulation-by-mutations-confering-resistance-of-virus-replication-to-cyclosporin-a
#1
Aurelie Badillo, Veronique Brechot, Stephane Sarrazin, François-Xavier Cantrelle, Frederic Delolme, Marie-Laure Fogeron, Jennifer Molle, Roland Montserret, Anja Bockmann, Ralf Bartenschlager, Volker Lohmann, Guy Lippens, Sylvie Ricard-Blum, Xavier Hanoulle, Francois Penin
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a RNA-binding phosphoprotein composed of a N-terminal membrane anchor (AH), a structured domain 1 (D1) and two intrinsically disordered domains (D2 and D3). The knowledge of the functional architecture of this multifunctional protein remains limited. We report here that NS5A-D1D2D3 produced in a wheat germ cell-free system is obtained under a highly phosphorylated state. Its NMR analysis revealed that these phosphorylations do not change the disordered nature of D2 and D3 domains but increase the number of conformers due to partial phosphorylations...
May 23, 2017: Biochemistry
https://www.readbyqxmd.com/read/28535138/paramedian-submandibular-approach-for-removal-of-foreign-bodies-in-the-pterygoid-muscle-in-two-dogs
#2
Elizabeth Gettinger, Daniel Smeak, Angela Marolf
The purpose of this report is to document a unique location of an oropharyngeal foreign body, diagnosed via contrast computed tomography (CT), as well as a novel surgical approach to the pterygoid muscle region. Oropharyngeal foreign objects are an uncommon but potentially serious disease that can lead to chronic abscessation and pain. Two dogs were presented with chronic complaints, including pain and inability to fully open the mouth for a 1 yr and 5 mo duration, respectively. There was no history or evidence of skin sinus or submandibular/cervical swelling on physical examination of either dog...
May 23, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28535137/the-effect-of-heart-disease-on-anesthetic-complications-during-routine-dental-procedures-in-dogs
#3
Jennifer E Carter, Alison A Motsinger-Reif, William V Krug, Bruce W Keene
Dental procedures are a common reason for general anesthesia, and there is widespread concern among veterinarians that heart disease increases the occurrence of anesthetic complications. Anxiety about anesthetizing dogs with heart disease is a common cause of referral to specialty centers. To begin to address the potential effect of heart disease on anesthetic complications in dogs undergoing anesthesia for routine dental procedures, we compared anesthetic complications in 100 dogs with heart disease severe enough to trigger referral to a specialty center (cases) to those found in 100 dogs without cardiac disease (controls) that underwent similar procedures at the same teaching hospital...
May 23, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28535136/eosinophilic-esophagitis-in-a-kitten
#4
Julie Pera, Douglas Palma, Taryn A Donovan
A 4 mo old intact male kitten was presented for chronic regurgitation and failure to thrive after weaning to dry food. Esophageal dilatation and severe diffuse proliferative lesions of the esophageal mucosa were found via radiography and esophagoscopy, respectively. Histopathologic examination revealed severe, chronic, diffuse, hyperplastic eosinophilic and mastocytic esophagitis. Eosinophilic infiltrates were prominent, with a mean of 29.8 eosinophils per high power field, supportive of eosinophilic esophagitis (EoE)...
May 23, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28535135/recovery-from-cyclophosphamide-overdose-in-a-dog
#5
Jessica Renee Finlay, Kenneth Wyatt, Courtney North
An adult female spayed dog was evaluated after inadvertently receiving a total dose of 1,750 mg oral cyclophosphamide, equivalent to 2,303 mg/m(2), over 21 days (days -21 to 0). Nine days after the last dose of cyclophosphamide (day +9), the dog was evaluated at Perth Veterinary Specialists. Physical examination revealed mucosal pallor, a grade 2/6 systolic heart murmur, and severe hemorrhagic cystitis. Severe nonregenerative pancytopenia was detected on hematology. Broad spectrum antibiotics, two fresh whole blood transfusions, granulocyte colony stimulating factor, and tranexamic acid were administered...
May 23, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28535134/upper-airway-obstruction-secondary-to-anticoagulant-rodenticide-toxicosis-in-five-dogs
#6
Corinne Lawson, Mauria O'Brien, Maureen McMichael
Five dogs were presented with clinical signs compatible with upper airway obstruction, including stridor, stertor, coughing, gagging, and varying degrees of respiratory distress. All dogs had radiographic findings of soft tissue opacity in the area of the pharynx, larynx, or trachea, and several had narrowing of the tracheal lumen. Coagulation abnormalities (prolonged prothrombin time, activated partial thromboplastin time) were present in the four dogs that underwent testing. Four of five dogs were treated for the coagulopathy, presumably due to anticoagulant rodenticide toxicosis, and survived to discharge...
May 23, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28535132/granulomatous-inflammatory-response-to-a-microchip-implanted-in-a-dog-for-eight-years
#7
Claire Legallet, Kelley Thieman Mankin, Kathy Spaulding, Joanne Mansell
An 8 yr old neutered male springer spaniel dog was referred to Texas A&M University, College of Veterinary Medicine for a large, firm, fixed mass, located in the dorsal cervical tissue. The dog was otherwise healthy and had undergone microchip implantation approximately 8 yr prior. Radiographs, ultrasound, and microchip scanner confirmed the presence of a microchip within the mass. The microchip and associated mass were surgically excised, and histopathologic examination revealed granulomatous inflammation surrounding a cracked microchip...
May 23, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28534721/evaluation-of-3d-additively-manufactured-canine-brain-models-for-teaching-veterinary-neuroanatomy
#8
Regina M Schoenfeld-Tacher, Timothy J Horn, Tyler A Scheviak, Kenneth D Royal, Lola C Hudson
Physical specimens are essential to the teaching of veterinary anatomy. While fresh and fixed cadavers have long been the medium of choice, plastinated specimens have gained widespread acceptance as adjuncts to dissection materials. Even though the plastination process increases the durability of specimens, these are still derived from animal tissues and they require periodic replacement if used by students on a regular basis. This study investigated the use of three-dimensional additively manufactured (3D AM) models (colloquially referred to as 3D-printed models) of the canine brain as a replacement for plastinated or formalin-fixed brains...
May 23, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28534468/effect-of-wearing-a-telemetry-jacket-on-behavioral-and-physiologic-parameters-of-dogs-in-the-open%C3%A2-field-test
#9
Richard E Fish, Melanie L Foster, Margaret E Gruen, Barbara L Sherman, David C Dorman
Safety pharmacology studies in dogs often integrate behavioral assessments made using video recording with physiologicmeasurements collected by telemetry. However, whether merely wearing the telemetry vest affects canine behavior and otherparameters has not been evaluated. This pilot study assessed the effect of a telemetry vest on behavioral and physiologic responses to an environmental stressor, the sounds of a thunderstorm, in Labrador retrievers. Dogs were assigned to one of 2 experimental groups (Vest and No-Vest, n = 8 dogs per group) by using a matched pairs design, with a previously determined,sound-associated anxiety score as the blocking variable...
May 22, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28534448/the-use-of-escherichia-coli-total-antigens-as-a-complementary-approach-to-address-seropositivity-to-leishmania-antigens-in-canine-leishmaniosis
#10
Carla Lima, João Rodrigo Mesquita, Hugo Brancal, Thomas Vahlenkamp, Ana Rafaela Teixeira, Luís Cardoso, Célia Amorim, Nuno Santarém, Anabela Cordeiro DA Silva
Canine leishmaniosis (CanL) is a major veterinary concern and a public health issue. Serological data are essential for disease management. Several antigens used in serological assays have specificity related problems preventing relevant seropositivity values establishment. Herein we report significant seropositivity level disparity in a study cohort with 384 dogs from eight countries, for antigens traditionally used in CanL - soluble promastigote Leishmania antigens (SPLA) and K39 recombinant protein (rK39): 43·8 and 2·9% for SPLA and rK39, respectively...
May 23, 2017: Parasitology
https://www.readbyqxmd.com/read/28534071/cloning-of-helicobacter-suis-cholesterol-%C3%AE-glucosyltransferase-and-production-of-an-antibody-capable-of-detecting-it-in-formalin-fixed-paraffin-embedded-gastric-tissue-sections
#11
Masatomo Kawakubo, Kazuki Horiuchi, Hitomi Komura, Yoshiko Sato, Masayoshi Kato, Meguru Ikeyama, Mana Fukushima, Shigenori Yamada, Satoshi Ishizone, Takehisa Matsumoto, Hiroyoshi Ota, Junji Sagara, Jun Nakayama
Helicobacter suis (H. suis), formerly called Helicobacter heilmannii type 1 (H. heilmannii), is a gram-negative bacterium of the Helicobacter species. This pathogen infects the stomach of humans and animals such as dogs, cats, pigs, and rodents, the latter giving rise to zoonotic infection. Here, we generated a H. suis-specific antibody useful for immunohistochemistry with formalin-fixed, paraffin-embedded tissue sections. To do so, we began by cloning the gene encoding H. suis cholesterol α-glucosyltransferase (αCgT)...
May 22, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28533404/repression-of-phosphatidylinositol-transfer-protein-%C3%AE-ameliorates-the-pathology-of-duchenne-muscular-dystrophy
#12
Natassia M Vieira, Janelle M Spinazzola, Matthew S Alexander, Yuri B Moreira, Genri Kawahara, Devin E Gibbs, Lillian C Mead, Sergio Verjovski-Almeida, Mayana Zatz, Louis M Kunkel
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease caused by X-linked inherited mutations in the DYSTROPHIN (DMD) gene. Absence of dystrophin protein from the sarcolemma causes severe muscle degeneration, fibrosis, and inflammation, ultimately leading to cardiorespiratory failure and premature death. Although there are several promising strategies under investigation to restore dystrophin protein expression, there is currently no cure for DMD, and identification of genetic modifiers as potential targets represents an alternative therapeutic strategy...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28533336/a-coding-variant-in-the-gene-bardet-biedl-syndrome-4-bbs4-is-associated-with-a-novel-form-of-canine-progressive-retinal-atrophy
#13
Tracy Chew, Bianca Haase, Roslyn Bathgate, Cali E Willet, Maria K Kaukonen, Lisa J Mascord, Hannes T Lohi, Claire M Wade
Progressive retinal atrophy is a common cause of blindness in the dog and affects over 100 breeds. It is characterized by gradual vision loss that occurs due to the degeneration of photoreceptor cells in the retina. Similar to the human counterpart retinitis pigmentosa, the canine disorder is clinically and genetically heterogeneous and the underlying cause remains unknown for many cases. We use a positional candidate gene approach to identify putative variants in the Hungarian Puli breed using genotyping data of 14 family-based samples (CanineHD BeadChip array, Illumina) and whole genome sequencing data of two proband and two parental samples (Illumina HiSeq 2000)...
May 22, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28533295/comparative-pathogenesis-of-autoimmune-diabetes-in-humans-nod-mice-and-canines-has-a-valuable-animal-model-of-type-1-diabetes-been-overlooked
#14
Allison L O'Kell, Clive Wasserfall, Brian Catchpole, Lucy J Davison, Rebecka S Hess, Jake A Kushner, Mark A Atkinson
Despite decades of research in humans and mouse models of disease, substantial gaps remain in our understanding of pathogenic mechanisms underlying the development of type 1 diabetes. Furthermore, translation of therapies from preclinical efforts capable of delaying or halting β-cell destruction has been limited. Hence, a pressing need exists to identify alternative animal models that reflect human disease. Canine insulin deficiency diabetes is, in some cases, considered to follow autoimmune pathogenesis, similar to NOD mice and humans, characterized by hyperglycemia requiring lifelong exogenous insulin therapy...
June 2017: Diabetes
https://www.readbyqxmd.com/read/28532993/canine-leptospirosis-in-switzerland-a-prospective-cross-sectional-study-examining-seroprevalence-risk-factors-and-urinary-shedding-of-pathogenic-leptospires
#15
Alessandro Delaude, Sabrina Rodriguez-Campos, Anou Dreyfus, Michel Jacques Counotte, Thierry Francey, Ariane Schweighauser, Sophie Lettry, Simone Schuller
Leptospirosis is an important worldwide zoonosis. While human leptospirosis remains rare in Switzerland, the incidence of canine leptospirosis is unusually high compared to other European countries. The aims of this cross-sectional study were to determine the exposure of asymtomatic dogs to pathogenic Leptospira in Switzerland, to characterise risk factors associated with seropositivity and to determine the prevalence of urinary shedding. Sampling was stratified to cover the whole of Switzerland. Sera were tested by microscopic agglutination test for antibodies against a panel of 12 serovars...
June 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28532988/molecular-and-serological-detection-of-trypanosoma-cruzi-in-dogs-canis-lupus-familiaris-suggests-potential-transmission-risk-in-areas-of-recent-acute-chagas-disease-outbreaks-in-colombia
#16
Jeiczon Jaimes-Dueñez, Omar Triana-Chávez, Omar Cantillo-Barraza, Carolina Hernández, Juan David Ramírez, Agustín Góngora-Orjuela
Chagas disease is a zoonotic infection widely distributed in tropical and subtropical regions of America, including more than 50% of the Colombian territory. In the last years, an increase of outbreaks of acute Chagas disease has been observed in the east of the country due to environmental changes and mammal movements toward human settlements. Given the importance of dogs (Canis lupus familiaris) as reservoir hosts and sentinels of Trypanosoma cruzi infection across different regions of America, in this study we reported a serological and molecular detection of T...
June 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28532833/estimation-of-fetal-lung-development-using-quantitative-analysis-of-ultrasonographic-images-in-normal-canine-pregnancy
#17
T Banzato, G Zovi, C Milani
We investigated the quantitative analysis of sonographic images to predict fetal lung maturity of the canine foetus in normal pregnancy. Twelve bitches were recruited in the present study. Serial ultrasonographic exams were performed at three pre-determined time periods corresponding to the pseudoglandular (40-48 days of pregnancy), canalicular (49-56 days of pregnancy) and saccular phase (57-63 days of pregnancy) of lung development. Mean grey level (MGL) and the standard deviation of the histogram (SDH) of fetal lung and liver sonographic images were measured with dedicated software...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28532806/a-molecular-survey-for-selected-viral-enteropathogens-revealed-a-limited-role-of-canine-circovirus-in-the-development-of-canine-acute-gastroenteritis
#18
Giulia Dowgier, Eleonora Lorusso, Nicola Decaro, Costantina Desario, Viviana Mari, Maria Stella Lucente, Gianvito Lanave, Canio Buonavoglia, Gabriella Elia
Canine circovirus (CanineCV) is a canine virus, whose pathogenetic role is still uncertain. Based on recent data suggesting its role as entheropathogen, a case-control study was conducted between 2013 and 2016 to investigate the association of CanineCV with gastroenteritis in dogs, alone or in combination with other viral pathogens, including canine parvovirus (CPV), canine coronavirus (CCoV) and canine distemper virus (CDV). A total of 219 dogs suffering from acute gastroenteritis disorders and 67 controls randomly recruited among healthy dogs or patients presenting without enteric signs were screened by a panel of real-time (RT-)PCR assays for CanineCV, CPV, CCoV and CDV...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28532790/a-safe-and-molecular-tagged-brucella-canis-ghosts-confers-protection-against-virulent-challenge-in-mice
#19
Jing Qian, Zhaoyang Bu, Xulong Lang, Guangmou Yan, Yanling Yang, Xiuran Wang, Xinglong Wang
Canine brucellosis, caused by Brucella canis, is a persistent infectious reproductive disease in dogs. The absence of effective treatment to the intracellular pathogen and the irreversible consequence of infection makes the need of a specific vaccine urgent. Bacterial ghosts (BGs) are the empty envelopes of bacteria with no genome content inside, which emerge as a proper vaccine candidate due to its intact outer antigen. It is generally derived from a genetically engineered strain, through the expression of Bacteriophage phiX174 lysis E gene upon induction...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28532402/antiviral-activity-of-phenanthrenes-from-the-medicinal-plant-bletilla-striata-against-influenza-a-virus
#20
Ya Shi, Bing Zhang, Yiyu Lu, Chaodong Qian, Yan Feng, Liwei Fang, Zhishan Ding, Dongqing Cheng
BACKGROUND: Influenza represents a serious public health concern. The emergence of resistance to anti-influenza drugs underlines the need to develop new drugs. This study aimed to evaluate the anti-influenza viral activity and possible mechanisms of 12 phenanthrenes from the medicinal plant Bletilla striata (Orchidaceae family). METHODS: Twelve phenanthrenes were isolated and identified from B. striata. Influenza virus A/Sydney/5/97 (H3N2) propagated in embryonated chicken eggs was used...
May 22, 2017: BMC Complementary and Alternative Medicine
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