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Ciclosporin or cyclosporine, dog or canine

Bryn Flinders, Lennart Huizing, Marjolein Van Heerden, Filip Cuyckens, Ulf Neumann, Luc van der Laan, Steven W M Olde Damink, Ron M A Heeren, Frank G Schaap, Rob J Vreeken
The liver is the primary organ involved in handling of bile salts, a class of amphipathic molecules with signaling activities as well as desired and detrimental detergent actions. To allow in-depth investigation of functions of bile salts in healthy and diseased liver, the spatial distribution of bile salt species within the liver needs to be studied. Therefore the aim of our study was to determine hepatic bile salt distribution and identify specific lipid markers that define the structural elements of the liver...
September 20, 2018: Analytical Chemistry
Wael Majdoub, Amal Mosbahi, Frederic Bonbled
Fournier gangrene is a rare fulminant necrotizing infection of the skin and soft tissue of the perineum that may result in rapid death. We describe the autopsy case of a 70-year-old female with uncontrolled diabetes mellitus who was found unexpectedly dead in her house where she lived with her dog. Examination of the body revelaed a deep necrotic ulceration of the perineum with exposure of the underlying deep muscles that was initially misinterpreted by police officers as post mortem animal predation. Medicolegal examination and histological and microbiological analyses eliminated this hypothesis and the diagnosis of septic multiorgan failure due to necrotizing fasciitis was retained as a cause of death...
September 19, 2018: Forensic Science, Medicine, and Pathology
Takashi Suzuki, Narumi Yamamoto, Hirotaka Kondo, Hisashi Shibuya
The neoplastic mass developed in the left flank of a Border Collie dog. The tumor was resected surgically and evaluated histologically and immunohistochemically. Histologically a moderate number of spindle cells were proliferated with staghorn, placentoid, and myxoid growth patterns and a lack of perivascular whirling. Immunohistochemically, the tumor cells were positive to vimentin, laminin, S-100 protein, CD34 and CD117 antibodies. They were negative to cytokeratin AE1/3, desmin, α-SMA and calponin antibodies...
September 19, 2018: Journal of Veterinary Medical Science
Hiroo Kanai, Ken Hagiwara, Aya Nukaya, Motoki Kondo, Akihide Aso
Laparoscopic cholecystectomy (LC) is widely accepted as the standard treatment for benign gall bladder diseases in humans because it has proven to be less invasive and safer than are traditional methods. However, the efficacy of LC in dogs remains unclear. The present study aimed to examine the short-term outcome of LC for benign gall bladder diseases in dogs. We enrolled 76 consecutive dogs that underwent LC for benign gall bladder diseases at our hospital between April 2008 and October 2016. Dogs with jaundice, gall bladder ruptures, abdominal effusion, or extrahepatic biliary obstruction were not excluded from the indication...
September 20, 2018: Journal of Veterinary Medical Science
Seijirow Goya, Tomoki Wada, Kazumi Shimada, Akiko Uemura, Ryou Tanaka
A 7-year-old Miniature Schnauzer presented with exercise intolerance and easy fatigability. Echocardiography revealed the presence of supravalvular pulmonary stenosis. The peak velocity through the stenosis was 6.4 m/sec, and the interventricular septum was flattened. Cutting balloon angioplasty was designed for the treatment of coronary artery stenosis, which was resistant to conventional balloon angioplasty. Accordingly, the dog underwent cutting balloon angioplasty and conventional balloon dilation. One month after treatment, it showed neither exercise intolerance nor easy fatigability...
September 20, 2018: Journal of Veterinary Medical Science
Kenneth E Remy, Irene Cortés-Puch, Steven B Solomon, Junfeng Sun, Benjamin M Pockros, Jing Feng, Juan J Lertora, Roy R Hantgan, Xiaohua Liu, Andreas Perlegas, H Shaw Warren, Mark T Gladwin, Daniel B Kim-Shapiro, Harvey G Klein, Charles Natanson
During the last half-century, numerous antiinflammatory agents were tested in dozens of clinical trials and have proven ineffective for treating septic shock. The observation in multiple studies that cell-free hemoglobin (CFH) levels are elevated during clinical sepsis and that the degree of increase correlates with higher mortality suggests an alternative approach. Human haptoglobin binds CFH with high affinity and, therefore, can potentially reduce iron availability and oxidative activity. CFH levels are elevated over approximately 24-48 hours in our antibiotic-treated canine model of S...
September 20, 2018: JCI Insight
Jennifer Deborah Wuerth, Matthias Habjan, Julia Wulle, Giulio Superti-Furga, Andreas Pichlmair, Friedemann Weber
Sandfly fever Sicilian virus (SFSV) is one of the most widespread and frequent members of the genus Phlebovirus (order Bunyavirales , family Phenuiviridae ) infecting humans. Being transmitted by Phlebotomus sandflies, SFSV causes a self-limiting acute, often incapacitating febrile disease ("sandfly fever", "pappataci fever" or "dog disease") that is known at least since the beginning of the 20th century. We show that, similar to other pathogenic phleboviruses, SFSV suppresses the induction of the antiviral type I interferon (IFN) system in an NSs-dependent manner...
September 19, 2018: Journal of Virology
Rita Lenkei, Sara Alvarez Gomez, Péter Pongrácz
The signs of separation related problems (SRP) may vary according to the inner state that triggers them - for example we found earlier that dogs with owner-reported SRP were characterized with a predominance of whining during a short isolation from the owner, meanwhile barking occurred independently of the owner-reported SRP status. Based on the theory that the owner represents a resource for the dog we hypothesise that there is an association between the permissive and inconsistent behaviour of the owner and the reduced frustration threshold in the dog, which consequently will show specific signs of SRP...
September 16, 2018: Behavioural Processes
Valentina Foglia Manzillo, Manuela Gizzarelli, Fabrizio Vitale, Serena Montagnaro, Alessandra Torina, Salvo Sotera, Gaetano Oliva
BACKGROUND: During last decade Lampedusa island (Italy) has been interested by a deep social change caused by the massive arrival of migrants from north Africa. The goal of this study was to evaluate current CanL burden and risk factors for Visceral Leishmaniosis (VL) on Lampedusa, actually based on very few data obtained in a previous study performed fifteen years ago. Two hundred and forty-two dogs were enrolled for the detection of Leishmania infantum infection by serology. In addition, an entomological investigation was performed to confirm the presence of Leishmania-vectors...
September 19, 2018: BMC Veterinary Research
Claudia Sommerer, Oliver Witzke, Frank Lehner, Wolfgang Arns, Petra Reinke, Ute Eisenberger, Bruno Vogt, Katharina Heller, Johannes Jacobi, Markus Guba, Rolf Stahl, Ingeborg A Hauser, Volker Kliem, Rudolf P Wüthrich, Anja Mühlfeld, Barbara Suwelack, Michael Duerr, Eva-Maria Paulus, Martin Zeier, Martina Porstner, Klemens Budde
BACKGROUND: Conversion from calcineurin inhibitor (CNI) therapy to a mammalian target of rapamycin (mTOR) inhibitor following kidney transplantation may help to preserve graft function. Data are sparse, however, concerning the impact of conversion on posttransplant diabetes mellitus (PTDM) or the progression of pre-existing diabetes. METHODS: PTDM and other diabetes-related parameters were assessed post hoc in two large open-label multicenter trials. Kidney transplant recipients were randomized (i) at month 4...
September 19, 2018: BMC Nephrology
Bernard E Rollin
Despite the fact that companion animals enjoy the status of "members of the family" in contemporary society, there are numerous diseases affecting the longevity of these animals and their quality of life. Some of the most pervasive and damaging problems accrue to pedigreed animals whose genetic lines contain many major and severe diseases which are detrimental to both the quality and length of life. If one considers the most popular dog breeds in the United States, the top 10 include the Labrador Retriever, German Shepherd, Golden Retriever, French Bulldog, Beagle, Poodle, Rottweiler, Yorkshire Terrier, and German Shorthaired Pointer...
September 18, 2018: Animals: An Open Access Journal From MDPI
Cho-Ying Lin, Whei-Lin Pan, Hom-Lay Wang
PURPOSE: To examine cone beam computed tomography (CBCT) anatomical findings, such as the concavity of the ridge and angulation of the tooth and alveolar ridge, either facial or palatal, in order to assess the potential clinical risks of performing flapless implant surgery. MATERIALS AND METHODS: CBCT images that met the inclusion criteria were examined. All images in maxillary anterior areas (canine to canine), facial bone thickness at 3 and 5 mm from the cementoenamel junction (CEJ), angulation of the tooth and alveolar ridge (Angle T: the angulation between the long axis of the tooth and the palatal plane; Angle D: the angulation between the long axis of the tooth and the midline of the ridge), the deepest point of facial concavity, the distance from the deepest point of facial concavity to the apex of the tooth and alveolar bone crest, nasopalatine canal, dehiscence, and fenestrations were measured and statistically analyzed...
September 2018: International Journal of Oral & Maxillofacial Implants
Moustafa Abdou ELsyad, Basma Adel Denewar, Ehab Abdelnabi Elsaih
PURPOSE: The aim of this study was to evaluate the clinical and radiographic peri-implant tissues of bar, Locator, and resilient telescopic attachments for two-implant stabilized overdentures in subjects with mandibular atrophied ridges. MATERIALS AND METHODS: Ninety edentulous individuals with mandibular ridge atrophy were randomly assigned into three equal groups and received two implants in the canine areas. Mandibular overdentures were constructed and attached to implants with Dolder bar attachments (BOD), resilient telescopes (TOD), and Locators (LOD)...
September 2018: International Journal of Oral & Maxillofacial Implants
Jae-Won Choi, Bo-Hyeok Yun, Chang-Mo Jeong, Jung-Bo Huh
PURPOSE: The aim of this study was to compare the retentive properties of an attachment with a nylon insert and an attachment with a polyetherketoneketone (PEKK) insert on two-implant mandibular overdentures during simulated masticatory loadings and insertion/removal cycles. MATERIALS AND METHODS: Two attachment systems with nylon inserts or PEKK inserts were investigated, including nylon/low, nylon/medium, nylon/high, PEKK/x-low, PEKK/low, PEKK/medium, and PEKK/high...
September 2018: International Journal of Oral & Maxillofacial Implants
Diego da Cunha Fontoura, Vinicius de Magalhães Barros, Claúdia Silami de Magalhães, Ricardo Rodrigues Vaz, Allyson Nogueira Moreira
PURPOSE: This study compared the vertical misfit of fixed implant-supported titanium (Ti6Al4V) and yttria-stabilized tetragonal zirconia frameworks milled using the computer-aided design/computer-aided manufacturing (CAD/CAM) Zirkonzahn system. MATERIALS AND METHODS: An aluminum mandibular master cast was used, and four analogs of the Regular CrossFit implant for straight multibase titanium alloy abutments (Institut Straumann) were fixed with self-curing acrylic resin in mandibular canine and second premolar tooth locations with the aid of a parallelometer...
September 2018: International Journal of Oral & Maxillofacial Implants
Annabel Botsford, Ellen N Behrend, Robert J Kemppainen, Philippe R Gaillard, Frank Oprandy, Hollie P Lee
BACKGROUND: Low-dose ACTH stimulation testing would lower cost and may increase sensitivity for identification of partial ACTH deficiency. HYPOTHESIS: (1) The low-dose ACTH stimulation test will provide comparable results to the standard-dose ACTH stimulation test in dogs suspected of hypoadrenocorticism and (2) partial ACTH deficiency exists in dogs and can result in chronic, intermittent gastrointestinal signs. ANIMALS: Thirty-one client-owned dogs suspected of having hypoadrenocorticism...
September 19, 2018: Journal of Veterinary Internal Medicine
Po-Han Ho, Tsen-Fang Tsai
Juvenile generalized pustular psoriasis (GPP) is rare and often resistant to conventional systemic therapy such as methotrexate, retinoic acid and cyclosporin A. GPP can be induced by deficiency of interleukin (IL)-36 receptor antagonist (DITRA). No standardized guidelines are available for juvenile GPP or DITRA, and a uniformly safe and effective biologic agent has not been identified. However, multiple biologics approved for use in plaque-type psoriasis have also been used in GPP. Herein, we report a case of a 6-year-old Taiwanese boy with GPP and homozygous mutation at c...
September 19, 2018: Journal of Dermatology
Miltiadis A Makrygiannakis, Eleftherios G Kaklamanos, Alexander Milosevic, Athanasios E Athanasiou
OBJECTIVES: Tooth wear, additional to the physiologic alterations of the dentition, may occur during orthodontic treatment. The objective of the present review was to investigate systematically the literature relevant to its progression in patients having undergone comprehensive orthodontic treatment. DATA SOURCES: Search without restrictions in eight databases since inception and hand searching until October 2017 was performed. DATA SELECTION: Studies evaluating tooth wear immediately before and after the completion of orthodontic treatment with fixed appliance were evaluated independently and in duplicate...
September 19, 2018: Journal of Orthodontics
Thorsten Grünheid, Brent E Larson
OBJECTIVES: To compare bracket survival and adhesive removal time between a flash-free and a conventional adhesive for orthodontic bracket bonding. MATERIALS AND METHODS: Forty-five consecutive patients had their maxillary incisors, canines, and premolars bonded with ceramic brackets using a flash-free adhesive (APC Flash-Free Adhesive, 3M Unitek, Monrovia, Calif) on one side and a conventional adhesive (APCII Adhesive, 3M Unitek) on the other side. The side allocation was randomized...
September 19, 2018: Angle Orthodontist
Alyson Raschkowan, M Kate Thomas, Joanne Tataryn, Rita Finley, Katarina Pintar, Andrea Nesbitt
Animal companionship can have many physical and psychological benefits; however, animals can also be a source of zoonotic infection, including enteric illnesses; it has been estimated that in Canada, nearly 85,000 enteric illnesses due to eight pathogens occur each year related to animal contact. There is a lack of baseline data on animal-related exposures in Canada and around the world. This information is critical to inform quantitative and qualitative risk assessments to prioritize intervention efforts in public health and reduce the associated burden of enteric illness...
September 19, 2018: Zoonoses and Public Health
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