keyword
https://read.qxmd.com/read/35092332/placental-cd34-immunohistochemistry-in-fetal-vascular-malperfusion-in-stillbirth
#1
JOURNAL ARTICLE
Jerzy Stanek, Alex Drach
AIM: To assess the use of CD34 immunostaining in diagnosing of fetal vascular malperfusion (FVM) in stillborns. METHODS: We examined 25 independent clinical (pregnancy and fetal outcomes) and 48 placental phenotypes in 100 placentas of consecutive stillborns at ≥20 weeks of gestation. Group 1 comprised 34 cases with no distal villous FVM; Group 2 comprised 36 placentas with clustered distal villous FVM (sclerotic villi, hypovascularity, stromal vascular karyorrhexis, and/or mineralization) determined using hematoxylin-eosin staining not upgraded by CD34 immunostaining, and Group 3 comprised 30 placentas with FVM diagnosed or upgraded by CD34 immunostaining (distal villous endothelial fragmentation and/or villous hypovascularity)...
March 2022: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/34675752/hemolytic-disease-of-the-newborn-a-review-of-current-trends-and-prospects
#2
REVIEW
Akshay Kiran Myle, Ghanim Hamid Al-Khattabi
Hemolytic disease of the newborn (HDN), also known as Erythroblastosis fetalis , is a hemolytic condition that predominantly affects rhesus-positive fetuses and infants born to rhesus-negative mothers. The pathophysiology of HDN begins with maternal antibodies attacking fetal red blood cells following alloimmunization due to rhesus or ABO incompatibility between the maternal and fetal blood. Previously, HDN was known to cause fetal death in 1% of all pregnancies, but with the advent of immunoprophylactic therapies, the condition can be currently fairly well managed with fewer complications if diagnosed early...
2021: Pediatric Health, Medicine and Therapeutics
https://read.qxmd.com/read/34587634/shallow-placentation-a-distinct-category-of-placental-lesions
#3
JOURNAL ARTICLE
Jerzy Stanek
OBJECTIVE:  Shallow placental implantation (SPI) features placental maldistribution of extravillous trophoblasts and includes excessive amount of extravillous trophoblasts, chorionic microcysts in the membranes and chorionic disc, and decidual clusters of multinucleate trophoblasts. The histological lesions were previously and individually reported in association with various clinical and placental abnormalities. This retrospective statistical analysis of a large placental database from high-risk pregnancy statistically compares placentas with and without a composite group of features of SPI...
September 29, 2021: American Journal of Perinatology
https://read.qxmd.com/read/34362525/-investigation-and-analysis-of-non-abo-hemolytic-disease-of-the-newborn
#4
JOURNAL ARTICLE
Yan-Ling Zheng, Qiang Hong, Qian-Ming Wang
OBJECTIVE: To study the serological detection characteristics and antibody specific distribution of hemolytic disease of the newborn (HDN) caused by irregular antibodies through retrospective case analysis. METHODS: A total of 3 047 suspected cases of HDN were submitted by the Neonatal Department of our hospital from January 2014 to December 2019. Non ABO-HDN cases confirmed in our laboratory were taken as the research objects, while some cases of ABO-HDN were randomly selected as control...
August 2021: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/33545630/cd15-immunostaining-improves-placental-diagnosis-of-fetal-hypoxia
#5
JOURNAL ARTICLE
Larissa Seidmann, Yevgeniy Kamyshanskiy, Daniel Christoph Wagner, Stefanie Zimmer, Wilfried Roth
INTRODUCTION: Fetal hypoxic events with unclear predictive value are a common indication for placenta examination. We evaluated whether the use of CD15 immunostaining can improve the assessment of severity and duration of fetal hypoxia. METHODS: We compared placentas (37-42 gestational weeks) from stillborns/newborns with birth asphyxia (BA) and non-hypoxic newborns. Placental findings were studied in following groups: (1) acute BA (n = 11) due to placental abruption, (2) non-acute BA (n = 121) due to non-acute conditions, (3) non-BA (n = 46) in pregnancies with preeclampsia and gestational diabetes, and (4) controls (n = 30)...
February 2021: Placenta
https://read.qxmd.com/read/32429723/small-for-gestational-age-placentas-associate-with-an-increased-risk-of-adverse-outcomes-in-pregnancies-complicated-by-either-type-i-or-type-ii-pre-gestational-diabetes-mellitus
#6
JOURNAL ARTICLE
Roman Starikov, Phinnara Has, Robert Wu, D Michael Nelson, Mai He
INTRODUCTION: One-fifth of pregnancies with pre-gestational diabetes mellitus (pre-DM) yield placentas <10th percentile small for gestational age (SGA), compared to a non-diabetic population. We hypothesized that SGA placentas of women with pre-DM, whether type I (T1DM) or type II (T2DM), exhibit distinct histopathological changes and pregnancy outcomes compared to pre-DM pregnancies with an AGA placenta. METHODS: We conducted a retrospective, cohort study of placentas from pregnant women enrolled in the Diabetes in Pregnancy Program at Brown University between 2003 and 2011, by comparing pre-DM patients with SGA placentas to pre-DM patients with AGA placental weights...
May 2022: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/31138053/patterns-of-placental-injury-in-congenital-anomalies-in-second-half-of-pregnancy
#7
JOURNAL ARTICLE
Jerzy Stanek
BACKGROUND: Placental pathology in fetal congenital anomalies in second half of pregnancy is largely unknown. METHODS: Twenty-six clinical and 45 independent placental phenotypes from pregnancies ≥20 weeks of gestation with congenital anomalies divided into 4 groups were retrospectively compared with analysis of variance or χ 2 with 3 degrees of freedom and with Bonferroni correction for multiple comparisons: group 1 : 112 cases with heart malformations (with or without chromosomal anomalies), group 2 : 41 cases with abnormal karyotypes and anomalies other than heart malformations, group 3 : 87 cases with intrathoracic or intraabdominal mass-forming anomalies (mostly congenital diaphragmatic hernias and adenomatoid airway malformation), and group 4 : 291 miscellaneous cases with mostly skeletal, renal, and central nervous system anomalies not fulfilling the criteria of inclusion into groups 1 to 3...
November 2019: Pediatric and Developmental Pathology
https://read.qxmd.com/read/27291942/fetal-hypoxia-secondary-to-severe-maternal-anemia-as-a-causative-link-between-blueberry-muffin-baby-and-erythroblastosis-a-case-report
#8
JOURNAL ARTICLE
Maria Pia De Carolis, Silvia Salvi, Iliana Bersani, Serafina Lacerenza, Costantino Romagnoli, Sara De Carolis
BACKGROUND: Neonatal blueberry muffin lesions are rare cutaneous eruptions, presenting as transient, non-blanching, red-violaceous papules, mostly localized in the trunk, head and neck, attributable to a marked dermal hematopoietic activity. Congenital infections of the TORCH complex (toxoplasmosis, other, rubella, cytomegalovirus and herpes) and hematological disorders have been classically associated with this neonatal dermatological manifestation. We report for the first time an unusual presentation of blueberry muffin lesions in a neonate born from a mother affected by severe anemia during pregnancy...
June 13, 2016: Journal of Medical Case Reports
https://read.qxmd.com/read/27232351/chorangiosis-of-chorionic-villi-what-does-it-really-mean
#9
JOURNAL ARTICLE
Jerzy Stanek
CONTEXT: -Chorangiosis has been regarded as a result of low-grade placental hypoxia associated with pregnancy risk factors and abnormal outcomes. It is unknown whether these are a consequence of chorangiosis itself or of associated other placental pathology. OBJECTIVE: -To prove that chorangiosis itself does not portend an increased risk for pregnancy unless associated with other placental pathology. DESIGN: -This retrospective statistical study analyzes 1231 consecutive placentas with diffuse or focal hypervascularity of chorionic villi: 328 with preuterine pattern of chronic hypoxic placental injury (group 1), 297 with uterine type of chronic hypoxic placental injury (group 2), and 606 cases with chorangiosis (group 3) not fulfilling the inclusion criteria for groups 1 or 2...
June 2016: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/26829179/case-report-severe-hemolytic-disease-of-the-fetus-and-newborn-due-to-anti-c-g
#10
JOURNAL ARTICLE
Riina Jernman, Vedran Stefanovic, Anu Korhonen, Katri Haimila, Inna Sareneva, Kati Sulin, Malla Kuosmanen, Susanna Sainio
Anti-G is commonly present with anti-D and/or anti-C and can confuse serological investigations. in general, anti-G is not considered a likely cause of severe hemolytic disease of the fetus and newborn (HDFN), but it is important to differentiate it from anti-D in women who should be administered anti-D immunoglobulin prophylaxis. We report one woman with three pregnancies severely affected by anti-C+G requiring intrauterine treatment and a review of the literature. In our case, the identification of the correct antibody was delayed because the differentiation of anti-C+G and anti-D+C was not considered important during pregnancy since the father was D-...
2015: Immunohematology
https://read.qxmd.com/read/26829177/blocked-d-phenomenon-and-relevance-of-maternal-serologic-testing
#11
JOURNAL ARTICLE
Ashish Jain, Vijay Kumawat, Neelam Marwaha
A blood requisition for double-volume exchange transfusion was received for a 2-day-old male child born to a 29-year-old multiparous female (P2002) referred to our institute having neonatal jaundice with encephalopathy; no maternal sample was received. the neonatal blood sample was typed as group A, D-, and the direct antiglobulin test (DAT) was strongly positive (4+) using the gel method. Mono-specific DAT showed the presence of IgG antibodies on neonatal red blood cells (RBCs). Acid elution and gentle heat elution (at 56°C) confirmed the presence of anti-D on neonatal RBCs...
2015: Immunohematology
https://read.qxmd.com/read/26708902/prevalence-and-specificity-of-red-blood-cell-alloantibodies-in-patients-from-china-during-1994-2013
#12
JOURNAL ARTICLE
Yang Yu, Yi Wang, Xiao-Lin Sun, Chun-Ya Ma, Xiao-Juan Zhang, Xiao-Zhen Guan, Lin-Feng Chen, De-Qing Wang
OBJECTIVE: To analyze the data about red blood cell alloantibodies in patients from mainland China and to provide evidence for formulating a management guideline. METHODS: The Chinese and English literatures about Chinese patients in mainland China published in periodicals were retrieved by CHKD, CNKI, CMJD and PubMed using the key words as unexpected antibody, irregular antibody, blood group antibody, hemolytic transfusion reaction (HTR), hemolytic disease of the newborn (HDN), hemolytic disease of the fetus and newborn (HDFN)...
December 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/26496681/severe-case-of-fetal-hemolytic-disease-caused-by-anti-c-w-requiring-serial-intrauterine-transfusions-complicated-by-pancytopenia-and-cholestasis
#13
JOURNAL ARTICLE
Susanne Macher, Thomas Wagner, Konrad Rosskopf, Friedrich Reiterer, Bence Csapo, Peter Schlenke, Philipp Klaritsch
BACKGROUND: Anti-C(w) are rarely found as a source for severe fetal and neonatal hemolytic diseases. We report a case with serial intrauterine transfusions complicated by pancytopenia and cholestasis in the neonatal period. CASE REPORT: A 37-year-old woman revealed anti-C(w) with a titer of 512 in her fourth pregnancy. The fetus developed fetal anemia and a severe hydrops requiring three intrauterine red blood cell (RBC) transfusions. After birth at 33 + 0 weeks the newborn presented only transfused RBCs and suffered from anemia, thrombocytopenia, leukopenia, and a cholestatic liver disease...
January 2016: Transfusion
https://read.qxmd.com/read/26422285/neonatal-bo-incompatibility-is-associated-with-a-positive-cord-blood-direct-antiglobulin-test-in-infants-of-black-ethnicity
#14
JOURNAL ARTICLE
Bülent Özgönenel, Geetika Kukreja, Barbara O'Malley, Martin H Bluth
ABO hemolytic disease of the newborn occurs almost exclusively in infants of blood group A and B who are born to group O mothers. Positive Direct Antiglobulin Test (DAT) can identify those infants who are at risk of developing the ABO hemolytic disease. Earlier studies have suggested that BO incompatibility is associated with a positive DAT in black infants. In this study we sought to determine whether ABO incompatibility type could be associated with a higher rate of DAT positivity or clinical hemolytic disease...
November 2015: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/26372913/what-is-the-value-of-a-blood-type
#15
EDITORIAL
Meghan Delaney
No abstract text is available yet for this article.
September 2015: Transfusion
https://read.qxmd.com/read/26308465/kell-and-kx-blood-group-systems
#16
REVIEW
Gregory A Denomme
The Kell and Kx blood group systems are expressed as covalently linked molecules on red blood cells (RBCs). The Kell blood group system is very polymorphic, with 35 antigens assigned to the system. The expression of Kell glycoprotein on RBCs is not critical to the erythrocyte function. However, the expression of KX is critical to normal morphology, and null mutations are associated with the McLeod neuroacanthocytosis syndrome. The immunogenicity of the K anigen is second only to the D anigen, and alloantibodies to Kell anigens can cause transfusion reactions and hemolytic disease of the fetus and newborn...
2015: Immunohematology
https://read.qxmd.com/read/26044515/fetal-erythroblastosis-may-be-an-indicator-of-neonatal-transient-hyperinsulinism
#17
JOURNAL ARTICLE
Hiroshi Mizumoto, Yoichi Iki, Sumie Yamashita, Masahiko Kawai, Toshiro Katayama, Daisuke Hata
BACKGROUND: Small for gestational age and birth asphyxia are associated with neonatal transient hyperinsulinism (THI). Some newborns with THI showed marked erythroblastosis on admission to our neonatal intensive care unit. OBJECTIVE: This study was designed to test our hypothesis that fetal erythroblastosis may be a risk factor for developing THI. METHODS: The records of all babies admitted to our neonatal intensive care unit within 24 h of birth between January 2010 and May 2014, and who were born after 34 weeks of gestation, were retrospectively reviewed...
2015: Neonatology
https://read.qxmd.com/read/25968929/the-prevalence-of-anti-k-in-canadian-prenatal-patients
#18
JOURNAL ARTICLE
Mindy Goldman, Debra Lane, Kathryn Webert, Robert Fallis
BACKGROUND: Anti-KEL1(K) is a major cause of hemolytic disease of the fetus and newborn. We utilized data from prenatal testing of patients in Western Canada to determine the frequency of anti-K. In Manitoba, we evaluated the frequency of transfusion as the likely cause for alloimmunization. We reviewed international practices to prevent alloimmunization. STUDY DESIGN AND METHODS: Prenatal patients undergo antibody screening using an automated testing platform and uniform testing algorithm...
June 2015: Transfusion
https://read.qxmd.com/read/25929611/anti-m-antibody-induced-prolonged-anemia-following-hemolytic-disease-of-the-newborn-due-to-erythropoietic-suppression-in-2-siblings
#19
JOURNAL ARTICLE
Atsushi Ishida, Hitoshi Ohto, Hiroyasu Yasuda, Yutaka Negishi, Hideki Tsuiki, Takeshi Arakawa, Yoshihito Yagi, Daisuke Uchimura, Toru Miyazaki, Wataru Ohashi, Shigeru Takamoto
Hemolytic disease of the newborn (HDN) arising from MNSs incompatibility is rare, with few reports of prolonged anemia and reticulocytopenia following HDN. We report the younger of 2 male siblings, both of whom had anti-M-induced HDN and anemia persisting for over a month. Peripheral reticulocytes remained inappropriately low for the degree of anemia, and they needed multiple red cell transfusions. Viral infections were ruled out. Corticosteroids were given for suspected pure red cell aplasia. Anemia and reticulocytopenia subsequently improved...
August 2015: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/25899660/haemolytic-disease-of-the-fetus-and-newborn
#20
REVIEW
M de Haas, F F Thurik, J M Koelewijn, C E van der Schoot
Haemolytic Disease of the Fetus and Newborn (HDFN) is caused by maternal alloimmunization against red blood cell antigens. In severe cases, HDFN may lead to fetal anaemia with a risk for fetal death and to severe forms of neonatal hyperbilirubinaemia with a risk for kernicterus. Most severe cases are caused by anti-D, despite the introduction of antental and postnatal anti-D immunoglobulin prophylaxis. In general, red blood cell antibody screening programmes are aimed to detect maternal alloimmunization early in pregnancy to facilitate the identification of high-risk cases to timely start antenatal and postnatal treatment...
August 2015: Vox Sanguinis
keyword
keyword
108328
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.