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https://www.readbyqxmd.com/read/29212608/clinical-islet-transplantation-for-type-1-diabetes-in-canada-referral-patterns-and-eligibility-assessment
#1
Ying Ling, Aashna Gill, Richard Oram, A M James Shapiro, Peter Senior
OBJECTIVES: Careful selection for clinical islet transplantation (CIT) is required because of limited organ supply and the risks for lifelong immunosuppression. However, the indications for this novel treatment may not be widely known, and selection criteria continue to evolve. We sought to describe the pattern of referrals to our centre and the most common factors determining eligibility for CIT. METHODS: We performed a retrospective chart review of all applications for CIT received at the University of Alberta between May 2009 and April 2012...
December 4, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29197429/the-economic-contribution-of-industry-sponsored-pharmaceutical-clinical-trials
#2
Dat T Tran, Ilke Akpinar, Richard Fedorak, Egon Jonsson, John Mackey, Lawrence Richer, Philip Jacobs
In pharmaceutical clinical trials, industrial sponsors pay for study drugs and related healthcare services. We conducted a study to determine industry's economic contribution of these trials to the Alberta healthcare system.  Methods: We used data from two trial centers for cancer and non-cancer trials at the University of Alberta. For each trial (cancer, non-cancer), we calculated the cost of drugs provided by the sponsors using the market price, the cost of clinical services, and the cost of administrative services that they paid...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29141073/forces-of-tool-tissue-interaction-to-assess-surgical-skill-level
#3
Taku Sugiyama, Sanju Lama, Liu Shi Gan, Yaser Maddahi, Kourosh Zareinia, Garnette R Sutherland
Importance: The application of optimal forces between surgical instruments and tissue is fundamental to surgical performance and learning. To date, this force has not been measured clinically during the performance of microsurgery. Objectives: To establish a normative catalog of force profiles during the performance of surgery, to compare force variables among surgeons with different skill levels, and to evaluate whether such a force-based metric determines or differentiates skill level...
November 15, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29096870/hypoplastic-left-heart-syndrome-is-not-a-predictor-of-worse-intermediate-mortality-post-fontan
#4
Billie-Jean Martin, Kandice Mah, Luke Eckersley, Joyce Harder, Charissa Pockett, Daryl Schantz, John Dyck, Mohammed Al Aklabi, Ivan M Rebeyka, David B Ross
BACKGROUND: An increasing proportion of those living with single ventricle physiology have hypoplastic left heart syndrome (HLHS). Our objective was to assess the association between HLHS and outcomes post Fontan operation. METHODS: All pediatric patients who underwent a Fontan procedure at the University of Alberta between 1996 and 2016 were included. Follow-up clinical data collected included early and late surgical or catheter reintervention, echocardiography, and long-term transplant-free survival...
October 30, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29095254/bibliometric-analysis-of-the-top-cited-articles-on-islet-transplantation
#5
Qiang-Hong Pu, Qiu-Ju Lyu, Huan Liu, Kai-Hua Fan
AIMS: To identify and characterize the top-cited articles in the field of islet transplantation. METHODS: We used the Science Citation Index Expanded database to identify the most frequently cited articles published after 1900. Articles were evaluated using the following characteristics: citation number, publication year, study design, references, country and institution of origin, authorship, and journal. Keyword analysis and citation networks were used to analyze research trends...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29031156/hiv-misdiagnosis-a-root-cause-analysis-leading-to-improvements-in-hiv-diagnosis-and-patient-care
#6
Raynell Lang, Carmen Charlton, Brenda Beckthold, Kiana Kadivar, Stephanie Lavoie, Debbie Caswell, Paul N Levett, Greg B Horsman, John Kim, M John Gill
BACKGROUND: Standard diagnostic testing for HIV infection has traditionally relied on a high sensitivity HIV antibody screening test using an enzyme-linked immunosorbent assay (ELISA) followed by a high specificity antibody confirmatory test such as a Western Blot. Recently several of the screening assays have been enhanced with an ability to identify p24 antigen thereby narrowing the diagnostic window. OBJECTIVES: To explore the implications of enhanced HIV screening methods that may be leading to HIV misdiagnoses...
October 9, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29025820/well-being-of-family-medicine-graduates
#7
Olga Szafran, Wayne Woloschuk, Jacqueline M I Torti, Douglas Myhre
OBJECTIVE: To determine family medicine graduates' professional and personal well-being, general health status, stress levels, coping strategies, and the degree to which they felt supported or isolated in professional life; and to compare findings by sex, practice location, and location of medical school (Canadian medical graduates [CMGs] vs international medical graduates [IMGs]). DESIGN: Retrospective, cross-sectional survey. SETTING: University of Alberta in Edmonton and the University of Calgary in Alberta...
October 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29022182/coexistent-rheumatoid-arthritis-and-gout-a-case-series-and-review-of-the-literature
#8
Lilia Olaru, Laura Soong, Sukhvinder Dhillon, Elaine Yacyshyn
Since 1964 to present, there have been more than 33 cases of concomitant rheumatoid arthritis (RA) and gout reported in the literature. The objective of this study is to present a case series of patients with coexistent rheumatoid arthritis and gout and to provide a review of the literature. A retrospective review of a rheumatology patient database at the University of Alberta was performed (2004-2017). Patient charts were reviewed and the 1987 ARA Revised Classification Criteria for RA and 1977 ARA Classification Criteria for gout were applied to each patient...
December 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28990017/associations-between-patients-understanding-of-periodontal-disease-treatment-compliance-and-disease-status
#9
Benjamin Hughes, Giseon Heo, Liran Levin
OBJECTIVE: The aim of the present study was to investigate the associations between patients' understanding of periodontal disease, their individual compliance to homecare, self-reported periodontal disease, and how they have been educated regarding their oral health. METHOD AND MATERIALS: A cross-sectional study was performed by distributing questionnaires to patients at the University of Alberta Dental Clinic. A survey consisting of 45 questions was constructed in order to quantify patients' understanding of periodontal disease (section 1), where they received their information, how often they have been instructed by dental practitioners, their homecare habits (section 2), and their self-reported periodontal status (section 3)...
October 6, 2017: Quintessence International
https://www.readbyqxmd.com/read/28951661/mechanical-circulatory-support-as-a-bridge-to-lung-transplantation-a-single-canadian-institution-review
#10
Katie Kinaschuk, Sabin J Bozso, Kieran Halloran, Ali Kapasi, Kathy Jackson, Jayan Nagendran
BACKGROUND: Lung transplant (LTx) waitlists continue to grow internationally. Consequently, more patients are progressing to require mechanical circulatory support (MCS) as a bridge to transplantation (BTT). MCS strategies include interventional lung assist (iLA) and venovenous (VV) and venoarterial (VA) extracorporeal membrane oxygenation (ECMO). We review our series of patients bridged with MCS while listed for LTx. METHODS: All consecutive patients, listed for LTx requiring MCS as a BTT at the University of Alberta from 2004 to 2015, were included...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28930035/calgary-edmonton-and-the-university-of-alberta-the-extraordinary-medical-mobilization-by-canada-s-newest-province
#11
Mark P Da Cambra, Vivian C McAlister
The Canadian contribution of medical services to the British Empire during the First World War was a national endeavour. Physicians from across the country enlisted in local regiments to join. No other region provided more physicians per capita than the newly formed province of Alberta. Largely organized through the Medical School of the University of Alberta, the No. 11 Canadian Field Ambulance out of Edmonton and the No. 8 Canadian Field Ambulance out of Calgary ultimately enlisted between one-third and half of the province's doctors to the war campaign...
September 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28923643/feasibility-of-lung-transplantation-from-donation-after-circulatory-death-donors-following-portable-ex%C3%A2-vivo-lung-perfusion-a-pilot-study
#12
J G Y Luc, K Jackson, J G Weinkauf, D H Freed, J Nagendran
BACKGROUND: Donation after circulatory death (DCD) has the potential to significantly alleviate the shortage of transplantable lungs. We report our initial experience with the use of portable ex vivo lung perfusion (EVLP) with the Organ Care System Lung device for evaluation of DCD lungs. METHODS: We performed a retrospective review of the DCD lung transplantation (LTx) experience at a single institution through the use of a prospective database. RESULTS: From 2011 to 2015, 208 LTx were performed at the University of Alberta, of which 11 were DCD LTx with 7 (64%) that underwent portable EVLP...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28922263/prospective-side-by-side-comparison-of-outcomes-and-complications-with-a-simple-versus-intensive-anticoagulation-monitoring-strategy-in-pediatric-extracorporeal-life-support-patients
#13
Jane S Yu, Ryan P Barbaro, Donald A Granoski, Mary E Bauman, M Patricia Massicotte, Laurance L Lequier, Gail M Annich, Lindsay M Ryerson
OBJECTIVES: A continuous infusion of unfractionated heparin is the most common anticoagulant used for pediatric patients on extracorporeal life support. The objective of this study was to compare extracorporeal life support complications and outcomes between two large-volume pediatric extracorporeal life support centers that use different anticoagulation strategies. DESIGN: Prospective, observational cohort study. SETTING: The University of Michigan used simple anticoagulation monitoring, whereas the University of Alberta used an intensive anticoagulation monitoring strategy...
November 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28912198/frequency-of-low-value-care-in-alberta-canada-a-retrospective-cohort-study
#14
Finlay A McAlister, Meng Lin, Jeff Bakal, Stafford Dean
OBJECTIVE: To determine how frequently 10 low-value services highlighted by Choosing Wisely are done and what factors influence their provision. METHODS: This is a retrospective cohort study using routinely collected health data from five linked data sets from 2012 to 2015 in the Canadian province of Alberta to determine the frequency with which 10 low-value services were provided. RESULTS: Between 2012 and 2015, 162 143 people (4% of all 3 814 536 adult Albertans and 5% of the 3 423 135 who saw a physician at least once in that time frame) received at least one of the 10 low-value services, including 29...
September 14, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28870248/functional-and-quality-of-life-outcomes-after-partial-glossectomy-a-multi-institutional-longitudinal-study-of-the-head-and-neck-research-network
#15
Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R Harris, Daniel A O'Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay, Risto-Pekka Happonen, Ilpo Kinnunen, Heikki Irjala, Tero Soukka, Juhani Laine
BACKGROUND: While aggressive treatment for oral cancer may optimize survival, decrements in speech and swallowing function and quality of life often result. This exploratory study investigated how patients recover their communicative function, swallowing ability, and quality of life after primary surgery [with or without adjuvant (chemo)radiation therapy] for tongue cancer over the course of the first year post-operation. METHODS: Patients treated for oral cancer at three institutions (University of Alberta Hospital, Mount Sinai Beth Israel Medical Center, and Turku University Hospital) were administered patient-reported outcomes assessing speech [Speech Handicap Index (SHI)], swallowing [(M...
September 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28851785/validation-of-two-case-definitions-to-identify-pressure-ulcers-using-hospital-administrative-data
#16
Chester Ho, Jason Jiang, Cathy A Eastwood, Holly Wong, Brittany Weaver, Hude Quan
OBJECTIVE: Pressure ulcer development is a quality of care indicator, as pressure ulcers are potentially preventable. Yet pressure ulcer is a leading cause of morbidity, discomfort and additional healthcare costs for inpatients. Methods are lacking for accurate surveillance of pressure ulcer in hospitals to track occurrences and evaluate care improvement strategies. The main study aim was to validate hospital discharge abstract database (DAD) in recording pressure ulcers against nursing consult reports, and to calculate prevalence of pressure ulcers in Alberta, Canada in DAD...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28841249/assessing-physician-knowledge-regarding-indications-for-a-primary-prevention-implantable-defibrillator-and-potential-barriers-for-referral
#17
Rochelle Bernier, Satish R Raj, Dat Tran, Lucy Reyes, Michel Sauve, Glen L Sumner, Derek V Exner, Roopinder K Sandhu
BACKGROUND: Although there is clear evidence to demonstrate that primary prevention implantable defibrillators (ICDs) reduce mortality in high-risk patients, ICDs are underutilized. Limited data exist assessing referring physicians' knowledge about guideline indications and attitudes towards ICDs, which may influence decision for referral. METHODS AND RESULTS: The Arrhythmia Working Group from the Alberta Cardiovascular and Stroke Strategic Clinical Network developed a web-based survey consisting of case scenarios regarding primary prevention ICD indications and a list of barriers for referral to aid in the design of a complex device care pathway...
November 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28818647/malocclusion-class-ii-division-1-skeletal-and-dental-relationships-measured-by-cone-beam-computed-tomography
#18
Yiling Xu, Heesoo Oh, Manuel O Lagravère
OBJECTIVES: The purpose of this study was to locate traditionally-used landmarks in two-dimensional (2D) images and newly-suggested ones in three-dimensional (3D) images (cone-beam computer tomographies [CBCTs]) and determine possible relationships between them to categorize patients with Class II-1 malocclusion. METHODS: CBCTs from 30 patients diagnosed with Class II-1 malocclusion were obtained from the University of Alberta Graduate Orthodontic Program database...
August 14, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28799798/abstracts-from-dietetic-research-event-june-8-and-9-2017
#19
(no author information available yet)
St John's, Newfoundland was the host city of the 2017 Dietitians of Canada Annual Conference. Through the support of Dietitians of Canada and CFDR, the 2017 event was both an exciting and informative exchange of research and experience-sharing efforts that inspired attendees. The submissions for this year's Canadian Foundation for Dietetic Research (CFDR) event represented the diversity of dietetic research conducted within Canada. The topics highlighted from this year's abstracts included: Clinical Research; Community-based Nutritional Care; Determinants of Food Choice; Dietary Intake; Dietetic Practice and Education; Food Security; Nutrition and Health Education; Nutritional Assessment and Therapy; Nutrition Attitudes; Nutrition Strategy Development Patient Services; Professional Development; Vulnerable Groups and their Nutritional Needs; and, Wellness and Public Health...
September 2017: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/28781051/an-exceptionally-preserved-three-dimensional-armored-dinosaur-reveals-insights-into-coloration-and-cretaceous-predator-prey-dynamics
#20
Caleb M Brown, Donald M Henderson, Jakob Vinther, Ian Fletcher, Ainara Sistiaga, Jorsua Herrera, Roger E Summons
Predator-prey dynamics are an important evolutionary driver of escalating predation mode and efficiency, and commensurate responses of prey [1-3]. Among these strategies, camouflage is important for visual concealment, with countershading the most universally observed [4-6]. Extant terrestrial herbivores free of significant predation pressure, due to large size or isolation, do not exhibit countershading. Modern predator-prey dynamics may not be directly applicable to those of the Mesozoic due to the dominance of very large, visually oriented theropod dinosaurs [7]...
August 21, 2017: Current Biology: CB
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