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https://www.readbyqxmd.com/read/29895238/proceedings-of-the-alberta-virology-conference-university-of-alberta-1-2-june-2017-edited-by-guido-van-marle-and-trushar-r-patel-virology-in-alberta-and-canada
#1
Guido van Marle, Trushar R Patel
No abstract text is available yet for this article.
April 2018: Biotechnology & Genetic Engineering Reviews
https://www.readbyqxmd.com/read/29878859/in-vitro-tests-for-aerosol-deposition-vi-realistic-testing-with-different-mouth-throat-models-and-in-vitro-in-vivo-correlations-for-a-dry-powder-inhaler-metered-dose-inhaler-and-soft-mist-inhaler
#2
Xiangyin Wei, Michael Hindle, Anubhav Kaviratna, Bao K Huynh, Renishkumar R Delvadia, Dennis Sandell, Peter R Byron
BACKGROUND: In vitro-in vivo correlations (IVIVC) for lung deposition may be established by testing inhalers in vitro with realistic mouth-throat (MT) models and inhalation profiles (IP). This study was designed to compare the currently available MT models and their ability to predict in vivo lung deposition. METHODS: Budelin® Novolizer® , Ventolin® Evohaler® , and Respimat® fenoterol were chosen to represent a dry powder inhaler (DPI), metered dose inhaler (MDI), and soft mist inhaler (SMI) in tests using eight MT models: small, medium, and large Virginia Commonwealth University (VCU) models; small, medium, and large oropharyngeal consortium (OPC) models, the medium adult Alberta Idealized Throat (AIT), and the United States Pharmacopeia (USP) Induction Port, with IPs that simulated those used by volunteers in lung scintigraphy studies...
June 7, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29878145/blastomyces-helicus-a-new-dimorphic-fungus-causing-fatal-pulmonary-and-systemic-disease-in-humans-and-animals-in-western-canada-and-united-states
#3
Ilan S Schwartz, Nathan P Wiederhold, Kimberly E Hanson, Thomas F Patterson, Lynne Sigler
Background: Blastomyces helicus (formerly Emmonsia helica) is a dimorphic fungus first isolated from a man who died of encephalitis in Alberta, Canada. The geographic range, epidemiology and clinical features of disease are unknown. Methods: We reviewed human and veterinary isolates of B. helicus identified among Blastomyces and Emmonsia isolates at the University of Alberta Microfungus Collection and Herbarium, UT Health San Antonio's Fungus Testing Laboratory, and ARUP Laboratories...
June 7, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29679167/hot-joints-myth-or-reality-a-thermographic-joint-assessment-of-inflammatory-arthritis-patients
#4
Britney Jones, Imran Hassan, Ross T Tsuyuki, Marla Francisca Dos Santos, A S Russell, Elaine Yacyshyn
Rheumatoid arthritis is a common inflammatory disease that causes destruction of joints. Accurate recognition of active disease has significant implications in determining appropriate treatment; however, there is significant inter-rater variability in clinical joint assessment. This study aimed to assess the utility of thermographic imaging in the evaluation of inflammatory arthritis activity as an adjunct to clinical assessment. This was a cross-sectional study of 79 subjects recruited from the University of Alberta Outpatient Rheumatology clinic comparing the hand joints of 49 patients with rheumatoid arthritis (RA) diagnosed by American College of Rheumatology (ACR) criteria to 30 healthy volunteers...
April 20, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29571068/robust-high-yield-1-tbq-production-of-cyclotron-based-sodium-99m-tc-pertechnetate
#5
J D Andersson, B Thomas, S V Selivanova, E Berthelette, J S Wilson, A J B McEwan, K Gagnon
This paper presents the irradiation and processing of high-current 100 Mo targets at the University of Alberta (UofA) in a GMP compliant setting. For purpose of comparison with a second production facility, additional studies at Centre Hospitalier Universitaire de Sherbrooke (CHUS) are also described. INTRODUCTION: More than 70% of today's diagnostic radiopharmaceuticals are based on 99m Tc, however the conventional supply chain for obtaining 99m Tc is fragile. The aim of this work was to demonstrate reliable high yield production and processing of 99m Tc with medium-energy, high-current, cyclotrons...
May 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29554146/evaluation-of-classical-and-novel-autoantibodies-for-the-diagnosis-of-primary-biliary-cholangitis-autoimmune-hepatitis-overlap-syndrome-pbc-aih-os
#6
Henry H Nguyen, Abdel Aziz Shaheen, Natalia Baeza, Ellina Lytvyak, Stefan J Urbanski, Andrew L Mason, Gary L Norman, Marvin J Fritzler, Mark G Swain
BACKGROUND AND AIMS: Up to 20% of Primary Biliary Cholangitis (PBC) patients are estimated to have features that overlap with Autoimmune Hepatitis (AIH). Patients with PBC-AIH overlap syndrome (PBC-AIH OS) have been reported to exhibit suboptimal responses to ursodeoxycholic acid therapy, and are more likely to progress to cirrhosis. Anti-double stranded DNA (anti-dsDNA) and anti-p53 have been previously suggested to be potential autoantibodies for identifying patients with PBC-AIH OS...
2018: PloS One
https://www.readbyqxmd.com/read/29519575/oral-feeding-outcomes-in-infants-with-esophageal-atresia-and-tracheoesophageal-fistula
#7
Mackenzie C Lees, Ioana Bratu, Maryna Yaskina, Michael van Manen
PURPOSE: The purpose of this study was to explore oral feeding outcomes in infants born with type-C esophageal atresia and tracheoesophageal fistula (EA/TEF). METHODS: A retrospective cohort study of all infants born between January 2005 and December 2015 undergoing surgery for type-C EA/TEF at the University of Alberta Hospital was performed. RESULTS: Fifty-seven infants were identified, of which 61.4% were exclusively orally feeding at discharge home...
May 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29511419/comparison-of-the-assessment-of-orthostatic-hypotension-using-peripheral-and-central-blood-pressure-measurements
#8
Kannayiram Alagiakrishnan, Ruojin Bu, Peter Hamilton, Ambikaipakan Senthilselvan, Raj Padwal
Background: Orthostatic hypotension (OH) is associated with falls and cardiovascular events. There is growing evidence that central blood pressure (CBP) is better than peripheral blood pressure (PBP) in predicting adverse outcomes. The objectives of this study were to assess 1) the prevalence of OH identified using PBP and CBP and the levels of agreement, 2) the respective associations between OH and falls and cardiovascular comorbidities, by PBP and CBP, and 3) the association of OH with arterial wall stiffness markers (augmentation pressure (AP) and augmentation index (AI))...
April 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29402100/collaborative-model-used-to-develop-a-resource-guide-for-communities-to-enhance-their-palliative-and-end-of-life-care-the-case-of-alberta-canada
#9
Kyle Whitfield
In response to the desire of community organizations in Alberta for information and guidance as they seek to improve palliative and end of life care in their communities, a large number of organizations collaborated to develop a resource guide. In order to achieve this goal, it was first necessary to identify the common information needs of Alberta communities as they pursue their vision for improving local Palliative and End-of-Life Care. A committee comprised of representatives from Alberta Health Services, Alberta Health, Alberta Hospice Palliative Care Association, Hospice Societies, University researchers, Indigenous Health and Palliative Care physicians surveyed numerous community groups and stakeholders about their information needs...
January 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29400091/fellowship-program-in-health-system-improvement-a-novel-approach-integrating-leadership-development-and-patient-centred-health-system-transformation
#10
Donald J Philippon, Stephanie Montesanti, Tania Stafinski
This article highlights a novel approach to professional development, integrating leadership, development and patient-centred health system transformation in the new Fellowship Program in Health System Improvement offered by the School of Public Health at the University of Alberta. Early assessment of the program is also provided.
March 2018: Healthcare Management Forum
https://www.readbyqxmd.com/read/29334037/improvement-in-the-prognosis-of-cerebral-venous-sinus-thrombosis-over-a-22-year-period
#11
Dustin Anderson, Julie Kromm, Thomas Jeerakathil
BACKGROUND: Cerebral venous thrombosis is a rare cause of stroke, with a number of well-defined risk factors. However, there exist few studies that describe trends in the prognosis of this disease over time. METHODS: A retrospective study was performed on patients diagnosed with cerebral venous thrombosis at the University of Alberta Hospital during two time periods: 1988-1998 (21 patients) and 1999-2009 (40 patients). Signs and symptoms, risk factors, imaging findings, etiologies, treatment modalities, and status at discharge were examined...
January 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29333494/ensuring-adequate-vascular-access-in-patients-with-major-trauma-a-quality-improvement-initiative
#12
Kevin Verhoeff, Rachelle Saybel, Pamela Mathura, Bonnie Tsang, Vanessa Fawcett, Sandy Widder
Ensuring adequate vascular access in major trauma patients prior to decompensative physiological processes is crucial to patient outcomes. Most protocols suggest achieving two 18-gauge or larger intravenous lines immediately in patients with major trauma. We discuss a quality improvement approach to ensure that >90% of patients with major trauma (as defined by an injury severity score ≥12) at a level one trauma centre receive timely and adequate fluid access. Applying Donabedian principles for process improvement, we used the Alberta Trauma Registry to perform a 4-month chart audit on patients with major trauma at the University of Alberta Hospital...
2018: BMJ open quality
https://www.readbyqxmd.com/read/29310703/management-of-persistent-epistaxis-using-floseal-hemostatic-matrix-vs-traditional-nasal-packing-a-prospective-randomized-control-trial
#13
Scott Murray, Adrian Mendez, Alexander Hopkins, Hamdy El-Hakim, Caroline C Jeffery, David W J Côté
BACKGROUND: Epistaxis is the most common emergent consultation to otolaryngology-head & neck surgery (OHNS) and with 60% of the population having experienced an episode and 1.6 in 10,000 requiring hospitalization in their lifetime. In preliminary studies Floseal® (Baxter, USA) Hemostatic Matrix has shown efficacy in up to 80% of persistent anterior epistaxis. We sought to evaluate the clinical efficacy and cost-effectiveness of Floseal® (Baxter, USA) compared to traditional nasal packing for persistent epistaxis...
January 8, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29238239/safe-qi-a-framework-to-overcome-the-challenges-of-implementing-a-quality-improvement-curriculum-into-a-residency-program
#14
Lawrence Cheung
Quality improvement (QI) is an essential component of medical practice. Medical students and residents must learn the skills to conduct clinical QI during their educational programs. Medical educators must create and implement a curriculum in QI to empower their students to develop this skill and knowledge. However, developing and implementing a QI curriculum may be challenging for some residency programs. Residency programs with a relatively short duration of training - for example, only 2 years - may be unable to implement an extensive QI curriculum without siphoning away time for other learning objectives...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29212608/clinical-islet-transplantation-for-type-1-diabetes-in-canada-referral-patterns-and-eligibility-assessment
#15
Ying Ling, Aashna Gill, Richard Oram, A M James Shapiro, Peter Senior
OBJECTIVES: Careful selection for clinical islet transplantation (CIT) is required because of limited organ supply and the risks for lifelong immunosuppression. However, the indications for this novel treatment may not be widely known, and selection criteria continue to evolve. We sought to describe the pattern of referrals to our centre and the most common factors determining eligibility for CIT. METHODS: We performed a retrospective chart review of all applications for CIT received at the University of Alberta between May 2009 and April 2012...
December 4, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29197429/the-economic-contribution-of-industry-sponsored-pharmaceutical-clinical-trials
#16
Dat T Tran, Ilke Akpinar, Richard Fedorak, Egon Jonsson, John Mackey, Lawrence Richer, Philip Jacobs
In pharmaceutical clinical trials, industrial sponsors pay for study drugs and related healthcare services. We conducted a study to determine industry's economic contribution of these trials to the Alberta healthcare system.  Methods: We used data from two trial centers for cancer and non-cancer trials at the University of Alberta. For each trial (cancer, non-cancer), we calculated the cost of drugs provided by the sponsors using the market price, the cost of clinical services, and the cost of administrative services that they paid...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29141073/forces-of-tool-tissue-interaction-to-assess-surgical-skill-level
#17
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29096870/hypoplastic-left-heart-syndrome-is-not-a-predictor-of-worse-intermediate-mortality-post-fontan
#18
Billie-Jean Martin, Kandice Mah, Luke Eckersley, Joyce Harder, Charissa Pockett, Daryl Schantz, John Dyck, Mohammed Al Aklabi, Ivan M Rebeyka, David B Ross
BACKGROUND: An increasing proportion of those living with single ventricle physiology have hypoplastic left heart syndrome (HLHS). Our objective was to assess the association between HLHS and outcomes post Fontan operation. METHODS: All pediatric patients who underwent a Fontan procedure at the University of Alberta between 1996 and 2016 were included. Follow-up clinical data collected included early and late surgical or catheter reintervention, echocardiography, and long-term transplant-free survival...
December 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29095254/bibliometric-analysis-of-the-top-cited-articles-on-islet-transplantation
#19
REVIEW
Qiang-Hong Pu, Qiu-Ju Lyu, Huan Liu, Kai-Hua Fan
AIMS: To identify and characterize the top-cited articles in the field of islet transplantation. METHODS: We used the Science Citation Index Expanded database to identify the most frequently cited articles published after 1900. Articles were evaluated using the following characteristics: citation number, publication year, study design, references, country and institution of origin, authorship, and journal. Keyword analysis and citation networks were used to analyze research trends...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29031156/hiv-misdiagnosis-a-root-cause-analysis-leading-to-improvements-in-hiv-diagnosis-and-patient-care
#20
Raynell Lang, Carmen Charlton, Brenda Beckthold, Kiana Kadivar, Stephanie Lavoie, Debbie Caswell, Paul N Levett, Greg B Horsman, John Kim, M John Gill
BACKGROUND: Standard diagnostic testing for HIV infection has traditionally relied on a high sensitivity HIV antibody screening test using an enzyme-linked immunosorbent assay (ELISA) followed by a high specificity antibody confirmatory test such as a Western Blot. Recently several of the screening assays have been enhanced with an ability to identify p24 antigen thereby narrowing the diagnostic window. OBJECTIVES: To explore the implications of enhanced HIV screening methods that may be leading to HIV misdiagnoses...
November 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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