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JOURNAL ARTICLE
Arife Yaşar, Hye-Jung Ryu, Emine Esen, İhsan Sarıoğlan, Dane Deemer, Bülent Çetin, Sang-Ho Yoo, Stephen R Lindemann, Byung-Hoo Lee, Yunus E Tunçil
The aim of this study was to evaluate the impacts of enzymatically synthesized α-glucans possessing α-1,4- and α-1,6-glucose linkages, and varying in branching ratio, on colonic microbiota composition and metabolic function. Four different α-glucans varying in branching ratio were synthesized by amylosucrase from Neisseria polysaccharea and glycogen branching enzyme from Rhodothermus obamensis. The branching ratios were found to range from 0 % to 2.8 % using GC/MS. In vitro fecal fermentation analyses (n = 8) revealed that the branching ratio dictates the short-chain fatty acid (SCFA) generation by fecal microbiota...
July 1, 2024: Carbohydrate Polymers
#22
JOURNAL ARTICLE
Qian Liu, Kangle Shi, Yunjing Bai, Fangyan Yang, Cong Lei, Xiaocong Wang, Ying Hu, Shiyao Wang, Ruikun Wang, Yuefan Yu, Xiaoyu Liu, Xinping Yu, Lingling Zhang, Ling Tang, Suqian Li, Qinggang Meng
OBJECTIVE: To assess and compare the composition of tongue coating microbiota among patients at different stages of rheumatoid arthritis (RA). METHODS: A total of 47 patients diagnosed with RA, as per the American College of Rheumatology criteria, and 10 healthy individuals were enrolled in this study. The RA patients were stratified considering their Disease Activity Score 28 (DAS28), a composite measure based on the 28 tender and swollen joint count and erythrocyte sedimentation rate (ESR)...
April 12, 2024: Microbial Pathogenesis
#23
JOURNAL ARTICLE
Daniel Golparian, Michelle J Cole, Leonor Sánchez-Busó, Michaela Day, Susanne Jacobsson, Thinushaa Uthayakumaran, Raquel Abad, Beatrice Bercot, Dominique A Caugant, Dagmar Heuer, Klaus Jansen, Sonja Pleininger, Paola Stefanelli, David M Aanensen, Benjamin Bluemel, Magnus Unemo
BACKGROUND: Regular quality-assured whole-genome sequencing linked to antimicrobial resistance (AMR) and patient metadata is imperative to elucidate the shifting gonorrhoea epidemiology, both nationally and internationally. We aimed to examine the gonococcal population in the European Economic Area (EEA) in 2020, elucidate emerging and disappearing gonococcal lineages associated with AMR and patient metadata, compare with 2013 and 2018 whole-genome sequencing data, and explain changes in gonococcal AMR and gonorrhoea epidemiology...
April 10, 2024: The Lancet. Microbe
#24
JOURNAL ARTICLE
L Andrés Eslava, C Carrasco Marco, J L Ramos Martí, B Ponce Buj, C Gimeno Cardona
No abstract text is available yet for this article.
April 12, 2024: Semergen
#25
JOURNAL ARTICLE
Impact of Protein Nanoparticle Shape on the Immunogenicity of Antimicrobial Glycoconjugate Vaccines.
Marta Dolce, Daniela Proietti, Silvia Principato, Fabiola Giusti, Giusy Manuela Adamo, Sara Favaron, Elia Ferri, Immaculada Margarit, Maria Rosaria Romano, Maria Scarselli, Filippo Carboni
Protein self-assembling nanoparticles (NPs) can be used as carriers for antigen delivery to increase vaccine immunogenicity. NPs mimic the majority of invading pathogens, inducing a robust adaptive immune response and long-lasting protective immunity. In this context, we investigated the potential of NPs of different sizes and shapes-ring-, rod-like, and spherical particles-as carriers for bacterial oligosaccharides by evaluating in murine models the role of these parameters on the immune response. Oligosaccharides from Neisseria meningitidis type W capsular polysaccharide were conjugated to ring-shape or nanotubes of engineered Pseudomonas aeruginosa Hemolysin-corregulated protein 1 (Hcp1cc) and to spherical Helicobacter pylori ferritin...
March 27, 2024: International Journal of Molecular Sciences
#26
JOURNAL ARTICLE
Ashish Tamhankar, Marie Wensien, Sergio A V Jannuzzi, Sayanti Chatterjee, Benedikt Lassalle-Kaiser, Kai Tittmann, Serena DeBeer
A novel covalent post-translational modification (lysine-NOS-cysteine) was discovered in proteins, initially in the enzyme transaldolase of Neisseria gonorrhoeae ( Ng TAL) [ Nature 2021 , 593 , 460-464], acting as a redox switch. The identification of this novel linkage in solution was unprecedented until now. We present detection of the NOS redox switch in solution using sulfur K-edge X-ray absorption spectroscopy (XAS). The oxidized Ng TAL spectrum shows a distinct shoulder on the low-energy side of the rising edge, corresponding to a dipole-allowed transition from the sulfur 1s core to the unoccupied σ* orbital of the S-O group in the NOS bridge...
April 12, 2024: Journal of Physical Chemistry Letters
#27
JOURNAL ARTICLE
A Kogler, B Sadoghi, A Draschl, D Chromy, L Binder, A Schiefer-Niederkorn, E L Hofmann-Wellenhof, P Wolf
BACKGROUND: The incidence of sexually transmitted infections (STIs) is unbridled and on the rise. Extragenital STIs (anal and pharyngeal infections) are commonly asymptomatic, resulting in delayed diagnosis and treatment and consequently higher chances of onward transmission. OBJECTIVE: The aim of this observational single-centre study was to determine the prevalence of STIs at extragenital sites in symptomatic and asymptomatic patients presenting at an STI outpatient clinic...
April 12, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#28
JOURNAL ARTICLE
Jessica A Collins, Alexandria A Oviatt, Pan F Chan, Neil Osheroff
Fluoroquinolones make up a critically important class of antibacterials administered worldwide to treat human infections. However, their clinical utility has been curtailed by target-mediated resistance, which is caused by mutations in the fluoroquinolone targets, gyrase and topoisomerase IV. An important pathogen that has been affected by this resistance is Neisseria gonorrhoeae , the causative agent of gonorrhea. Over 82 million new cases of this sexually transmitted infection were reported globally in 2020...
April 12, 2024: ACS Infectious Diseases
#29
JOURNAL ARTICLE
Ter Tiero Elias Dah, Irith De Baetselier, Benjamin Cuer, Camille Anoma, Ephrem Mensah, Amadou Koné, Souba Diandé, Claver Anoumou Dagnra, Hortense Yaobla Faye-Kette, Alain Yeo, Issifou Yaya, Bruno Spire, Bintou Dembélé Keita, Tania Crucitti, Bea Vuylsteke, Christian Laurent
OBJECTIVES: Although oral pre-exposure prophylaxis (PrEP) for HIV is being rolled out in West Africa, data on sexually transmitted infections (STIs) in PrEP users are scarce. We assessed the prevalence, incidence and determinants of bacterial STIs in men who have sex with men (MSM) taking PrEP in Burkina Faso, Côte d'Ivoire, Mali and Togo. METHODS: A prospective cohort study among MSM initiating PrEP as part of a comprehensive HIV prevention package was conducted between 2017 and 2021 in community-based clinics in the four study countries...
April 11, 2024: Sexually Transmitted Infections
#30
JOURNAL ARTICLE
Stéphanie Pascual, Brooklyn Noble, Nusreen Ahmad-Saeed, Catherine Aldridge, Simone Ambretti, Sharon Amit, Rachel Annett, Shaan Ashk O'Shea, Anna Maria Barbui, Gavin Barlow, Lucinda Barrett, Mario Berth, Alessandro Bondi, Nicola Boran, Sara E Boyd, Catarina Chaves, Martin Clauss, Peter Davies, Ileana T Dianzo-Delgado, Jaime Esteban, Stefan Fuchs, Lennart Friis-Hansen, Daniel Goldenberger, Andrej Golle, Juha O Groonroos, Ines Hoffmann, Tomer Hoffmann, Harriet Hughes, Marina Ivanova, Peter Jezek, Gwennan Jones, Zeynep Ceren Karahan, Cornelia Lass-Flörl, Frédéric Laurent, Laura Leach, Matilde Lee Horsbøll Pedersen, Caroline Loiez, Maureen Lynch, Robert J Maloney, Martin Marsh, Olivia Milburn, Shanine Mitchell, Luke S P Moore, Lynn Moffat, Marianna Murdjeva, Michael E Murphy, Deepa Nayar, Giacomo Nigrisoli, Fionnuala O'Sullivan, Büşra Öz, Teresa Peach, Christina Petridou, Mojgan Prinz, Mitja Rak, Niamh Reidy, Gian Maria Rossolini, Anne-Laure Roux, Patricia Ruiz-Garbajosa, Kordo Saeed, Llanos Salar-Vidal, Carlos Salas Venero, Mathyruban Selvaratnam, Eric Senneville, Peter Starzengruber, Ben Talbot, Vanessa Taylor, Rihard Trebše, Deborah Wearmouth, Birgit Willinger, Marjan Wouthuyzen-Bakker, Brianne Couturier, Florence Allantaz
Introduction : The BIOFIRE Joint Infection (JI) Panel is a diagnostic tool that uses multiplex-PCR testing to detect microorganisms in synovial fluid specimens from patients suspected of having septic arthritis (SA) on native joints or prosthetic joint infections (PJIs). Methods : A study was conducted across 34 clinical sites in 19 European and Middle Eastern countries from March 2021 to June 2022 to assess the effectiveness of the BIOFIRE JI Panel. Results : A total of 1527 samples were collected from patients suspected of SA or PJI, with an overall agreement of 88...
2024: Journal of Bone and Joint Infection
#31
JOURNAL ARTICLE
Shamez N Ladhani, Savio Fernandes, Mamta Garg, Ray Borrow, Simon de Lusignan, Paula H B Bolton-Maggs
Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen were published by the British Committee for Standards in Haematology in 1996 and updated in 2002 and 2011. With advances in vaccinations and changes in patterns of infection, the guidelines required updating. Key aspects included in this guideline are the identification of patients at risk of infection, patient education and information and immunisation schedules. This guideline does not address the non-infective complications of splenectomy or functional hyposplenism (FH)...
April 10, 2024: British Journal of Haematology
#32
JOURNAL ARTICLE
Rui Min Li, Zhe Long, Xiao Yan Ding, Li Duan
Oral microecological dysregulation has been shown to be associated with various immune system disorders. Henoch-schonlein purpura (HSP) is an autoimmune small vessel inflammatory disease in children of uncertain etiology, and studies have suggested that streptococcal infection may be an influential factor in its development. However, the relationship between oral microecological dysregulation and HSP has not been clearly studied so far. In this study, an epidemiological survey on the oral health status of children with HSP was investigated in this paper, and collected dental plaque from four groups of children for 16SrDNA high-throughput sequencing to analyze the composition and changes of oral microbial diversity among different groups...
April 15, 2024: Heliyon
#33
JOURNAL ARTICLE
Monica M Lahra, Sebastiaan Van Hal, Tiffany R Hogan
The Australian National Neisseria Network (NNN) comprises reference laboratories in each state and territory that report data on antimicrobial susceptibility testing to an agreed group of antimicrobial agents for the Australian Gonococcal Surveillance Programme (AGSP). The AGSP data are presented quarterly in tabulated form, as well as in the AGSP annual report. This report presents national gonococcal antimicrobial resistance surveillance data from 1 July to 30 September 2023.
March 31, 2024: Communicable Diseases Intelligence
#34
JOURNAL ARTICLE
Monica M Lahra, Sebastiaan Van Hal, Tiffany R Hogan
The Australian National Neisseria Network (NNN) comprises reference laboratories in each state and territory that report data on antimicrobial susceptibility testing to an agreed group of antimicrobial agents for the Australian Gonococcal Surveillance Programme (AGSP). The AGSP data are presented quarterly in tabulated form, as well as in the AGSP annual report. This report presents national gonococcal antimicrobial resistance surveillance data from 1 April to 30 June 2023.
March 31, 2024: Communicable Diseases Intelligence
#35
JOURNAL ARTICLE
Monica M Lahra, Sebastiaan Van Hal, Tiffany R Hogan
The Australian National Neisseria Network (NNN) comprises reference laboratories in each state and territory that report data on antimicrobial susceptibility testing to an agreed group of antimicrobial agents for the Australian Gonococcal Surveillance Programme (AGSP). The AGSP data are presented quarterly in tabulated form, as well as in the AGSP annual report. This report presents national gonococcal antimicrobial resistance surveillance data from 1 January to 31 March 2023.
March 31, 2024: Communicable Diseases Intelligence
#36
JOURNAL ARTICLE
M M Lahra, N H Latham, D J Templeton, P Read, C Carmody, N Ryder, S E Ellis, E F Madden, A Parasuraman, J Wells, V Sheppeard, B H Armstrong, J Holland, S Pendle, N Sherry, L Leong, L Papanicolas, C E Selvey, S J Van Hal
In 2023, an increased number of urogenital and anorectal infections with Neisseria meningitis serogroup Y (MenY) were reported in New South Wales (NSW). Whole genome sequencing (WGS) found a common sequence type (ST-1466), with limited sequence diversity. Confirmed outbreak cases were NSW residents with a N. meningitidis isolate matching the cluster sequence type; probable cases were NSW residents with MenY isolated from a urogenital or anorectal site from 1 July 2023 without WGS testing. Of the 41 cases, most were men (n = 27), of whom six reported recent contact with a female sex worker...
April 10, 2024: Communicable Diseases Intelligence
#37
JOURNAL ARTICLE
María Aguilera-Franco, María Tarriño-León, M J Olivares-Durán, Beatriz Espadafor, Javier Rodríguez-Granger, Juan Antonio Reguera, Fernando Cobo, Antonio Sampedro, José María Navarro
Sexually transmitted infections (STI) are a public health problem. Real-time PCR assays are the most sensitive test for screening and diagnosis of these infections. The aim of this study was to evaluate a new CT/NG/TV/MG Real-Time PCR (RT-PCR) kit (Vircell) for the detection of Chamydia trachomatis , Neisseria gonorrhoeae , Mycoplasma genitalium and Trichomonas vaginalis for the diagnosis of sexual transmitted infections using the Allplex STI Essential Assay (Seegene) as the reference's method. A total of 497 samples from different anatomical sites (endocervical, urethral, rectal, pharyngeal and urine) were analysed from October 2022 to February 2023...
April 2024: Journal of Medical Microbiology
#38
JOURNAL ARTICLE
Sylvia Kusemererwa, Eugene Ruzagira, Martin Onyango, Anita Kabarambi, Andrew Abaasa
OBJECTIVES: We assessed associations between intravaginal practices (IVPs) and the incidence of sexually transmitted infections (STIs) and bacterial vaginosis (BV) among women using the dapivirine vaginal ring (DVR) or placebo vaginal ring in southwestern Uganda. METHODS: This was a retrospective secondary analysis of data collected from women at risk of HIV infection recruited into the Ring Study. The latter evaluated the safety and efficacy of the DVR between 2013 and 2016...
April 8, 2024: BMJ Open
#39
JOURNAL ARTICLE
Amaris J Cardenas, Keena S Thomas, Mary W Broden, Noel J Ferraro, Marcos M Pires, Constance M John, Gary A Jarvis, Alison K Criss
UNLABELLED: Gonorrhea, caused by the bacterium Neisseria gonorrhoeae (Gc), is characterized by neutrophilic influx to infection sites. Gc has developed mechanisms to resist killing by neutrophils that include modifications to its surface lipooligosaccharide (LOS). One such LOS modification is sialylation: Gc sialylates its terminal LOS sugars with cytidine-5'-monophosphate- N -acetylneuraminic acid, which is scavenged from the host using LOS sialyltransferase (Lst) since Gc cannot make its sialic acid...
April 9, 2024: MBio
#40
JOURNAL ARTICLE
Masahiro Morita, Takayuki Nambu, Ryota Yamasaki, Yoshie Nagai-Yoshioka, Maki Inoue, Tatsuji Nishihara, Toshinori Okinaga, Wataru Ariyoshi
BACKGROUND: Periodontitis is the most common oral disease in dogs, and its progression and severity are influenced by risk factors, such as age and body size. Recent studies have assessed the canine oral microbiota in relation to different stages of periodontitis and niches within the oral cavity. However, knowledge of the bacterial composition at different ages and body sizes, especially in puppies, is limited. This study aimed to characterize the oral microbiota in the healthy gingiva of small breed puppies using next-generation sequencing...
April 5, 2024: BMC Veterinary Research
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