keyword
MENU ▼
Read by QxMD icon Read
search

neisseria

keyword
https://www.readbyqxmd.com/read/29773626/draft-genome-sequences-for-a-diverse-set-of-isolates-from-10-neisseria-species
#1
Megan Nichols, Nadav Topaz, Xiong Wang, Xin Wang, Dave Boxrud
Neisseria is a diverse genus that includes commensal and pathogenic species that pose a public health threat. While the pathogenic species have been studied extensively, many of the commensals have limited genomic information available. Here, we present draft genome sequences for a diverse set of 37 isolates from 10 Neisseria species.
May 17, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29770081/increase-in-neisseria-meningitidis-serogroup-w-invasive-disease-in-canada-2009-2016
#2
Rsw Tsang, L Hoang, G J Tyrrell, G Horsman, P Van Caeseele, F Jamieson, B Lefebvre, D Haldane, R R Gad, G J German, G Zahariadis
No abstract text is available yet for this article.
July 6, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29767396/are-lactoferrin-receptors-in-gram-negative-bacteria-viable-vaccine-targets
#3
Clement Chan, Vahid F Andisi, Dixon Ng, Nick Ostan, Warren K Yunker, Anthony B Schryvers
A number of important Gram-negative pathogens that reside exclusively in the upper respiratory or genitourinary tract of their mammalian host rely on surface receptors that specifically bind host transferrin and lactoferrin as a source of iron for growth. The transferrin receptors have been targeted for vaccine development due to their critical role in acquiring iron during invasive infection and for survival on the mucosal surface. In this study, we focus on the lactoferrin receptors, determining their prevalence in pathogenic bacteria and comparing their prevalence in commensal Neisseria to other surface antigens targeted for vaccines; addressing the issue of a reservoir for vaccine escape and impact of vaccination on the microbiome...
May 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29766652/mucosal-microflora-in-head-and-neck-cancer-patients
#4
A Almståhl, C Finizia, A Carlén, B Fagerberg-Mohlin, T Alstad
OBJECTIVE: To analyse the tongue and buccal microflora prospectively in head and neck cancer patients treated with radiation therapy (RT). METHODS: In 33 dentate patients, microbial samples from the tongue and buccal mucosa were collected pretreatment, during treatment, and 6 months, 1 year and 2 years post-treatment. Microorganisms associated with oral health and oral disorders were analysed using cultivation technique. Oral mucositis was scored at the appointment during treatment...
May 15, 2018: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/29764949/toward-an-improved-meningococcal-serogroup-b-assay
#5
Jan Poolman
Because of diverse sequences and differential expression of surface structures on individual invasive Neisseria meningitidis serogroup B (MenB) strains, predicting the efficacy of MenB vaccines using traditional human serum bactericidal assays (hSBA) is impractical. The meningococcal antigen surface expression (MEASURE) assay uses flow cytometry to quantitate the expression of factor H binding proteins (fHbp) contained in the bivalent rLP2086 MenB vaccine. To date, experience with MEASURE has been lacking, and in a long-awaited article, McNeil et al...
May 15, 2018: MBio
https://www.readbyqxmd.com/read/29764940/the-tetrameric-structure-of-sialic-acid-synthesizing-udp-glcnac-2-epimerase-from-acinetobacter-baumannii-a-comparative-study-with-human-gne
#6
Tzu-Ping Ko, Shu-Jung Lai, Tung-Ju Hsieh, Chia-Shin Yang, Yeh Chen
Sialic acid presentation on the cell surface by some pathogenic strains of bacteria allows their escape from the host immune system. It is one of the major virulence factors. Bacterial biosynthesis of sialic acids starts with the conversion of UDP-GlcNAc to UDP and ManNAc by a hydrolyzing 2-epimerase. Here we present the crystal structure of this enzyme, named NeuC, from Acinetobacter baumannii The protein folds into two Rossmann-like domains and forms dimers and tetramers as does the epimerase part of the bifunctional UDP-GlcNAc 2-epimerase / ManNAc kinase (GNE)...
May 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29763438/phasome-analysis-of-pathogenic-and-commensal-neisseria-species-expands-the-known-repertoire-of-phase-variable-genes-and-highlights-common-adaptive-strategies
#7
Joseph J Wanford, Luke R Green, Jack Aidley, Christopher D Bayliss
Pathogenic Neisseria are responsible for significantly higher levels of morbidity and mortality than their commensal relatives despite having similar genetic contents. Neisseria possess a disparate arsenal of surface determinants that facilitate host colonisation and evasion of the immune response during persistent carriage. Adaptation to rapid changes in these hostile host environments is enabled by phase variation (PV) involving high frequency, stochastic switches in expression of surface determinants. In this study, we analysed 89 complete and 79 partial genomes, from the NCBI and Neisseria PubMLST databases, representative of multiple pathogenic and commensal species of Neisseria using PhasomeIt, a new program that identifies putatively phase-variable genes and homology groups by the presence of simple sequence repeats (SSR)...
2018: PloS One
https://www.readbyqxmd.com/read/29760215/specific-binding-to-differentially-expressed-human-ceacams-determines-the-outcome-of-neisseria-gonorrhoeae-infections-along-the-female-reproductive-tract
#8
Epshita A Islam, Varun C Anipindi, Ian Francis, Yazdan Shaik-Dasthagirisaheb, Stacey Xu, Nelly Leung, Anna Sintsova, Mohsen Amin, Charu Kaushic, Lee M Wetzler, Scott D Gray-Owen
The gonococcal Opa proteins are an antigenically variable family of surface adhesins that bind human CEACAM1, CEACAM3, CEACAM5 and/or CEACAM6, cell surface glycoproteins that are differentially expressed on a broad spectrum of human cells and tissues. While presumed to be important for infection, the significance of various Opa-CEACAM mediated cellular interactions in the context of the genital tract has remained unclear. Here, we observe that CEACAM1 and CEACAM5 are differentially expressed on epithelia lining the upper and lower portions of the human female genital tract, respectively...
May 14, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29757696/a-refugee-patient-with-meningococcal-meningitis-type-b
#9
Aslinur Ozkaya-Parlakay, Saliha Kanik-Yuksek, Belgin Gulhan, Hasan Tezer, Filiz Altay, Nuriye Unal-Sahin
Neisseria meningitidis infection constitutes still a major health problem with significant morbidity and mortality. In this report a 2 year old refugee Turkoman boy admitting with fever and vomitting diagnosed as meningococcal meningitis type B who was cured with intravenous ceftriaxone therapy was presented to emphasize importance of implementing new strategies for health care of refugees.
May 14, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29754466/temporal-trends-in-paediatric-bacterial-meningitis-in-a-tropical-australian-region-1992-2014
#10
Stephanie White, Hala Katf, Rob Baird, Joshua Francis
AIM: The epidemiology of community-acquired bacterial meningitis has changed following the introduction of routine immunisation against common causative organisms. Indigenous children living in the Northern Territory, Australia, have high rates of bacterial infections. This study describes changes in the epidemiology of childhood bacterial meningitis and the distribution of the burden of disease in the Top End. METHODS: A retrospective review of cases derived from hospital medical records and laboratory data was performed...
May 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29752412/properly-folded-and-functional-porb-from-neisseria-gonorrhoeae-inhibits-dendritic-cell-stimulation-of-cd4-t-cell-proliferation
#11
Weiyan Zhu, Joshua Tomberg, Kayla J Knilans, James E Anderson, Karen P McKinnon, Gregory D Sempowski, Robert A Nicholas, Joseph A Duncan
Neisseria gonorrhoeae is an exclusive human pathogen that evades the host immune system through multiple mechanisms. We have shown that N. gonorrhoeae  suppresses the capacity of antigen-presenting cells to induce CD4+ T cell proliferation. In this study, we sought to determine the gonococcal factors involved in this adaptive immune suppression. We show that suppression of the capacity of antigen-pulsed dendritic cells to induce T cell proliferation is recapitulated by administration of a high molecular weight fraction of conditioned medium from N...
May 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29748180/molecular-test-for-chlamydia-and-gonorrhoea-used-at-point-of-care-in-remote-primary-healthcare-settings-a-diagnostic-test-evaluation
#12
Louise M Causer, Rebecca J Guy, Sepehr N Tabrizi, David M Whiley, David John Speers, James Ward, Annie Tangey, Steven G Badman, Belinda Hengel, Lisa Jane Natoli, David A Anderson, Handan Wand, David Wilson, David G Regan, Mark Shephard, Basil Donovan, Christopher K Fairley, John M Kaldor
OBJECTIVES: A new molecular test for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) (GeneXpert CT/NG) has been demonstrated to be as accurate as conventional nucleic acid amplification tests (NAAT), but performance has not been evaluated in routine primary care, performed at the point of care by clinicians. We aimed to examine its diagnostic performance when used by clinicians in remote community health services in Australia with high prevalences of CT and NG infection. The trial was registered with the Australian and New Zealand Clinical Trials Registry (#12613000808741) METHODS: At 12 health services, training was provided to 99 clinicians in the use of the GeneXpert CT/NG assay who tested specimens from all patients undergoing STI screening...
May 10, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29746535/gonorrhea-chlamydia-and-hiv-incidence-among-female-sex-workers-in-cotonou-benin-a-longitudinal-study
#13
Souleymane Diabaté, Annie Chamberland, Nassirou Geraldo, Cécile Tremblay, Michel Alary
Female sex workers (FSWs) continue to carry a heavy burden of sexually transmitted infections (STI). For prevention purposes, there is a need to identify most-at-risk subgroups among them. The objective of this longitudinal cohort study conducted at Dispensaire IST, Cotonou, Benin, was to assess Neisseria gonorrhoeae (NG) / Chlamydia trachomatis (CT) incidence and determinants; and HIV incidence among FSWs in presence of STI/HIV risk reduction activities. Overall, 319 adult FSWs were followed quarterly from September 2008 to March 2012...
2018: PloS One
https://www.readbyqxmd.com/read/29743304/molecular-characterization-of-invasive-isolates-of-neisseria-meningitidis-in-casablanca-morocco
#14
Aziza Razki, Eva Hong, Khalid Zerouali, Houria Belabbes, Khadija Aitmouss, Aude Terrade, Bahija Zaki, Ala-Eddine Deghmane, Naima Elmdaghri, Muhamed-Kheir Taha
Meningococcal epidemiology may change unpredictably and typing of isolates of Neisseria meningitidis is crucial for the surveillance of invasive meningococcal disease (IMD). Few data are available of the meningococcal epidemiology in countries of North Africa. We aimed to explore the invasive meningococcal isolates from the Casablanca region in Morocco. We used whole genome sequencing (WGS) to characterize 105 isolates from this region during the period 2011-2016. Our data showed that the majority (n=100) of the isolates belonged to serogroup B...
May 9, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29739760/primary-meningococcal-septic-arthritis-with-multiple-native-joint-involvement
#15
Connor Boyle, Thomas Howard, David Griffith, Jonathan Cowie
A previously healthy 18-year-old woman presented with an acutely painful, swollen right ankle joint, with similar symptoms subsequently developing in the right hip and right wrist. Microbiological samples from the ankle aspirate grew Neisseria meningitidis She had had no preceding clinical symptoms of meningitis or previous contact with a patient with meningitis. She was treated with intravenous antibiotics and surgical drainage.On follow-up, her symptoms had resolved, inflammatory markers had returned to normal and she has no long-term sequelae of septic arthritis...
May 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29738073/the-closo-dodecaborate-dianion-fused-with-oxazoles-provides-3d-diboraheterocycles-with-selective-antimicrobial-activity
#16
Yuji Sun, Jianglin Zhang, Yuanbin Zhang, Jiyong Liu, Stijn van der Veen, Simon Duttwyler
The synthesis and application of icosahedral boron cluster compounds has been studied extensively since their discovery several decades ago; however, two aspects of their chemistry have received little attention: The possibility to form inorganic/organic fused boraheterocycles and their potential to act as antimicrobial agents. This work comprises the preparation of a class of three-dimensional diborabenzoxazole analogues with the closo-dodecaborate in place of the benzene moiety. The presented synthetic procedures provide access to a wide range of diboraheterocycles under mild conditions...
May 8, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29737965/identification-and-characterization-of-a-novel-single-chain-variable-fragment-scfv-antibody-against-neisseria-meningitidis-factor-h-binding-protein-fhbp
#17
Fatemeh Yarian, Bahram Kazemi, Mojgan Bandehpour
PURPOSE: Neisseria meningitidis is the leading global cause of meningitis and sepsis. Detection, followed by identification, of bacterial pathogens is important in medicine and public health. In the present study, we used the ribosome display technique to select single-chain variable fragments (scFv) that are specific to the surface-exposed fHbp antigen of N. meningitidis. METHODOLOGY: The recombinant fHbp protein was used as the antigen for the immunization of BALB/c mice...
May 8, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29735685/acquisition-of-virulence-genes-by-a-carrier-strain-gave-rise-to-the-ongoing-epidemics-of-meningococcal-disease-in-west-africa
#18
Ola Brønstad Brynildsrud, Vegard Eldholm, Jon Bohlin, Kennedy Uadiale, Stephen Obaro, Dominique A Caugant
In the African meningitis belt, a region of sub-Saharan Africa comprising 22 countries from Senegal in the west to Ethiopia in the east, large epidemics of serogroup A meningococcal meningitis have occurred periodically. After gradual introduction from 2010 of mass vaccination with a monovalent meningococcal A conjugate vaccine, serogroup A epidemics have been eliminated. Starting in 2013, the northwestern part of Nigeria has been affected by yearly outbreaks of meningitis caused by a novel strain of serogroup C Neisseria meningitidis (NmC)...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29734757/capture-of-pb-2-and-cu-2-metal-cations-by-neisseria-meningitidis-type-capsular-polysaccharides
#19
Sujan Ghimire, Pumtiwitt C McCarthy
Heavy metal pollution of water is a significant environmental and public health concern. Current biological strategies for heavy metal removal from water are performed using microbial biopolymers, including polysaccharides, that are already fully formed. This creates limitations in adapting polysaccharides to increase binding affinity for specific metals. We propose that altering the specificity of polysaccharide-producing enzymes could be beneficial to improving metal capture by modified polysaccharides. We assess binding of Cu2+ and Pb2+ metal cations to Neisseria meningitidis -type polysaccharides...
May 5, 2018: Biomolecules
https://www.readbyqxmd.com/read/29733249/alternative-antimicrobials-the-properties-of-fatty-acids-and-monoglycerides
#20
Colin P Churchward, Raid G Alany, Lori A S Snyder
With the rising antibiotic resistance of many bacterial species, alternative treatments are necessary to combat infectious diseases. The World Health Organization and the US Centres for Disease Control and Prevention have warned that some infections, such as those from Neisseria gonorrhoeae, may be untreatable within a few years. One avenue of exploration is the use of antimicrobial fatty acids and their derivatives for therapeutic prevention or treatment of bacterial infections. Several studies have explored the activity of fatty acids and their derivatives, including monoglycerides against a variety of bacterial species...
May 7, 2018: Critical Reviews in Microbiology
keyword
keyword
108318
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"