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https://www.readbyqxmd.com/read/28303829/mutation-pattern-in-the-genome-of-neisseria-gonorrhoeae-and-its-association-with-multidrug-resistant-isolates-from-delhi-india
#1
Divya Sachdev, Indu Kumari, Manju Bala, Vineet Kumar, Daman Saluja
Mutations in PenA, PorB, MtrE and MtrR genes responsible for antimicrobial resistance were checked in 27 drug-resistant clinical isolates of Neisseria gonorrhoeae (NG). Phenotype PIB (88.88%) and mutation at G120 and A121 positions of porB were recurrent. N122K, a novel mutation, was observed in PorB in three resistant isolates. Substitution H105Y in MtrR was widespread (37% of clinical isolates). The presence of a novel mutation (L33V), along with G45D mutation in MtrR, was associated with less-resistant isolates, in contrast to isolates with G45D mutation alone...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28302376/emerging-trends-in-antibiotic-resistance-implications-for-emergency-medicine
#2
Ali Pourmand, Maryann Mazer-Amirshahi, Gregory Jasani, Larissa May
BACKGROUND: Many bacteria are demonstrating increasing levels of resistance to commonly used antibiotics. While this has implications for the healthcare system as a whole, many patients infected with these resistant organisms will initially present to the emergency department (ED). The purpose of this review is to provide a summary of current trends in infections caused by the most clinically relevant resistant organisms encountered in emergency medicine. METHODS: Bacteria were selected based on the Centers for Disease Control and Prevention's National Action Plan for Combating Antibiotic Resistant Bacteria, and PubMed database...
March 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28301990/risk-factors-for-community-acquired-bacterial-meningitis
#3
Lene Fogt Lundbo, Thomas Benfield
BACKGROUND: Bacterial meningitis is a significant burden of disease and mortality in all age groups worldwide despite the development of effective conjugated vaccines. The pathogenesis of bacterial meningitis is based on complex and incompletely understood host-pathogen interactions. Some of these are pathogen-specific, while some are shared between different bacteria. METHODS: We searched the database PubMed to identify host risk factors for bacterial meningitis caused by the pathogens Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae type b, because they are three most common causative bacteria beyond the neonatal period...
June 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28301989/routine-testing-of-mycoplasma-genitalium-and-trichomonas-vaginalis
#4
Marieke L M Jenniskens, Jan H W Veerbeek, Koen L Deurloo, Erik J van Hannen, Steven F T Thijsen
BACKGROUND: Mycoplasma genitalium (MG) and Trichomonas vaginalis (TV) are common sexual transmitted infections (STI). However, most STI screening programmes do not include routinely detection of these pathogens. Consequently, epidemiological data about MG and TV in the general population is lacking. The current study aims to give insight into the prevalence of both infections, thereby guiding decisions whether testing for these pathogens should be included routinely. METHODS: Between February 2013 and August 2015, all samples sent to the laboratory of Diakonessenhuis Utrecht for STI testing (i...
June 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28290950/survey-of-sexually-transmitted-disease-laboratory-methods-in-u-s-army-laboratories-2012
#5
Nicole K Leamer, Nikki N Jordan, Laura A Pacha, Nabil H Latif, Eric C Garges, Joel C Gaydos
INTRODUCTION: Sexually transmitted diseases (STD) affect primarily young people (17-24 years). The U.S. Military, with many young people, strives to maintain effective STD treatment and prevention programs using current methods. Laboratory testing technology and capacity are important for appropriate clinical management and to provide data to direct prevention programs. STD laboratory capabilities are assessed in civilian and military laboratories using surveys. An Army laboratory survey was conducted in 2007...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28290948/mortality-surveillance-for-infectious-diseases-in-the-u-s-department-of-defense-1998-2013
#6
Robert N Potter, Ladd A Tremaine, Joel C Gaydos
INTRODUCTION: The Mortality Surveillance Division (MSD) of the U.S. Armed Forces Medical Examiner System was established in 1998 to improve surveillance for all military deaths although emphasizing deaths from infectious diseases. Establishment of the MSD was part of the 1997 Department of Defense initiative to improve surveillance and response for emerging infectious diseases. Before 1998, mortality surveillance was limited to compiling information from death certificates, a system that provided limited useful information and lacked the timeliness needed to take meaningful action to address emerging infectious disease threats...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28290510/acquisition-of-the-capsule-locus-by-horizontal-gene-transfer-in-neisseria-meningitidis-is-often-accompanied-by-the-loss-of-udp-galnac-synthesis
#7
Stephanie N Bartley, Shakeel Mowlaboccus, Christopher A Mullally, Keith A Stubbs, Alice Vrielink, Martin C J Maiden, Odile B Harrison, Timothy T Perkins, Charlene M Kahler
Pathogenic meningococci have acquired a 24 kb capsule synthesis island (cps) by horizontal gene transfer which consists of a synthetic locus and associated capsule transport genes flanked by repetitive Regions D and D'. Regions D and D' contain an intact gene encoding a UDP-galactose epimerase (galE1) and a truncated remnant (galE2), respectively. In this study, GalE protein alleles were shown to be either mono-functional, synthesising UDP-galactose (UDP-Gal), or bi-functional, synthesising UDP-Gal and UDP-galactosamine (UDP-GalNAc)...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28282646/point-of-care-sexually-transmitted-infection-diagnostics-proceedings-of-the-star-sexually-transmitted-infection-clinical-trial-group-programmatic-meeting
#8
Anthony D Cristillo, Claire C Bristow, Rosanna Peeling, Barbara Van Der Pol, Sasha Herbst de Cortina, Ivan K Dimov, Nitika Pant Pai, Dong Jin Shin, Ricky Y T Chiu, Catherine Klapperich, Purnima Madhivanan, Sheldon R Morris, Jeffrey D Klausner
The goal of the point-of-care (POC) sexually transmitted infection (STI) Diagnostics meeting was to review the state-of-the-art research and develop recommendations for the use of POC STI diagnostics. Experts from academia, government, nonprofit, and industry discussed POC diagnostics for STIs such as Chlamydia trachomatis, human papillomavirus, Neisseria gonorrhoeae, Trichomonas vaginalis, and Treponema pallidum. Key objectives included a review of current and emerging technologies, clinical and public health benefits, POC STI diagnostics in developing countries, regulatory considerations, and future areas of development...
April 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28282645/haemophilus-influenzae-isolated-from-men-with-acute-urethritis-its-pathogenic-roles-responses-to-antimicrobial-chemotherapies-and-antimicrobial-susceptibilities
#9
Shin Ito, Kyoko Hatazaki, Ken Shimuta, Hiromi Kondo, Kosuke Mizutani, Mitsuru Yasuda, Keita Nakane, Tomohiro Tsuchiya, Shigeaki Yokoi, Masahiro Nakano, Makoto Ohinishi, Takashi Deguchi
BACKGROUND: There have been few comprehensive studies on Haemophilus influenza-positive urethritis. METHODS: In this retrospective study, we enrolled 68 men with H. influenzae-positive urethritis, including coinfections with Neisseria gonorrhoeae, Chlamydia trachomatis, and/or genital mycoplasmas: 2, 3, 20, and 43 treated with ceftriaxone, levofloxacin, sitafloxacin, and extended-release azithromycin (azithromycin-SR), respectively. We assessed microbiological outcomes in 54 men and clinical outcomes in 46 with H...
April 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28282644/antimicrobial-susceptibility-evaluation-and-multiple-locus-variable-number-tandem-repeat-analysis-of-neisseria-gonorrhoeae-isolates-in-china-in-2012
#10
Rui-Xing Yu, Yueping Yin, Xiu-Qin Dai, Shao-Chun Chen, Yan Han, Bing-Jie Zheng, Guo-Yi Zhang, Xiang-Sheng Chen
OBJECTIVE: This study aimed to gain information on the antimicrobial susceptibility and molecular epidemiological typing of Neisseria gonorrhoeae (NG) isolates in China in 2012. METHODS: A total of 244 NG isolates were consecutively recovered from patients with uncomplicated gonorrhea attending sexually transmitted disease clinics in 3 Chinese cities-Guangzhou, Nanjing, and Tianjin-in 2012. Neisseria gonorrhoeae susceptibilities to penicillin and tetracycline were examined by detecting penicillinase-producing NG (PPNG) and high-level tetracycline-resistant NG, and NG susceptibilities to ciprofloxacin, spectinomycin, ceftriaxone, and cefixime were determined using an agar dilution method...
April 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28282386/strong-incidence-of-pseudomonas-aeruginosa-on-bacterial-rrs-and-its-genetic-structures-of-cystic-fibrosis-sputa
#11
Laurence Pages-Monteiro, Romain Marti, Carine Commun, Nolwenn Alliot, Claire Bardel, Helene Meugnier, Michele Perouse-de-Montclos, Philippe Reix, Isabelle Durieu, Stephane Durupt, Francois Vandenesch, Jean Freney, Benoit Cournoyer, Anne Doleans-Jordheim
Cystic fibrosis (CF) lungs harbor a complex community of interacting microbes, including pathogens like Pseudomonas aeruginosa. Meta-taxogenomic analysis based on V5-V6 rrs PCR products of 52 P. aeruginosa-positive (Pp) and 52 P. aeruginosa-negative (Pn) pooled DNA extracts from CF sputa suggested positive associations between P. aeruginosa and Stenotrophomonas and Prevotella, but negative ones with Haemophilus, Neisseria and Burkholderia. Internal Transcribed Spacer analyses (RISA) from individual DNA extracts identified three significant genetic structures within the CF cohorts, and indicated an impact of P...
2017: PloS One
https://www.readbyqxmd.com/read/28282365/antimicrobial-resistance-surveillance-for-neisseria-gonorrhoeae-what-do-we-really-need-to-know-to-guide-public-health-interventions
#12
David A Lewis
No abstract text is available yet for this article.
April 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28277801/the-immunogenicity-and-safety-of-a-hib-menac-vaccine-a-non-inferiority-randomized-observer-blind-trial-in-infants-aged-3-5-months
#13
Yu-Xiao Wang, Hong Tao, Jian-Li Hu, Jing-Xin Li, Wei-Ming Dai, Jin-Fang Sun, Pei Liu, Jie Tang, Wen-Yu Liu, Feng-Cai Zhu
BACKGROUND: The objective of this study was to evaluate the immunogenicity and safety of the novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroup A and C-tetanus toxoid conjugate vaccine (Hib-MenAC). RESEARCH DESIGN AND METHODS: We conducted a non-inferiority, randomized, observer-blind, positive control clinical trial in 900 healthy infants aged between 3-5 months in Funing County, Jiangsu Province, China. Participants were randomly allocated, in a ratio of 2:1 (block=6), to receive experimental combined Hib-MenAC vaccines co-administrated with placebo or the co-administration of licensed Hib vaccine and MenAC vaccine, according to a three-dose immunization schedule...
March 9, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28272393/experimental-vaccine-induces-th1-driven-immune-responses-and-resistance-to-neisseria-gonorrhoeae-infection-in-a-murine-model
#14
Y Liu, L A Hammer, W Liu, M M Hobbs, R A Zielke, A E Sikora, A E Jerse, N K Egilmez, M W Russell
Female mice were immunized intravaginally with gonococcal outer membrane vesicles (OMVs) plus microencapsulated interleukin-12 (IL-12), and challenged using an established model of genital infection with Neisseria gonorrhoeae. Whereas sham-immunized and control animals cleared the infection in 10-13 days, those immunized with OMV plus IL-12 cleared infection with homologous gonococcal strains in 6-9 days. Significant protection was also seen after challenge with antigenically distinct strains of N. gonorrhoeae, and protective anamnestic immunity persisted for at least 6 months after immunization...
March 8, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28266109/role-of-microbial-biofilms-in-the-maintenance-of-oral-health-and-in-the-development-of-dental-caries-and-periodontal-diseases-consensus-report-of-group-1-of-the-joint-efp-orca-workshop-on-the-boundaries-between-caries-and-periodontal-disease
#15
Mariano Sanz, David Beighton, Michael A Curtis, Jaime A Cury, Irene Dige, Henrik Dommisch, Roger Ellwood, Rodrigo Giacaman, David Herrera, Mark C Herzberg, Eija Könönen, Philip D Marsh, Joerg Meyle, Alex Mira, Ana Molina, Andrea Mombelli, Marc Quirynen, Eric C Reynolds, Lior Shapira, Egija Zaura
BACKGROUND AND AIMS: The scope of this working group was to review (1) ecological interactions at the dental biofilm in health and disease, (2) the role of microbial communities in the pathogenesis of periodontitis and caries, and (3) the innate host response in caries and periodontal diseases. RESULTS AND CONCLUSIONS: A health-associated biofilm includes genera such as Neisseria, Streptococcus, Actinomyces, Veillonella and Granulicatella. Microorganisms associated with both caries and periodontal diseases are metabolically highly specialized and organized as multispecies microbial biofilms...
March 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28264906/inactivation-of-nmb0419-encoding-a-sel1-like-repeat-slr-protein-in-neisseria-meningitidis-is-associated-with-differential-expression-of-genes-belonging-to-the-fur-regulon-and-reduced-intra-epithelial-replication
#16
Ming-Shi Li, Paul R Langford, J Simon Kroll
Neisseria meningitidis is a commensal microbe that colonizes the human nasopharynx but occasionally invades the bloodstream to cause life-threatening infection. N. meningitidis MC58 NMB0419 encodes a Sel1-like repeat (SLR)-containing protein, previously implicated in invasion of epithelial cells. A gene-regulatory function was revealed in Escherichia coli expressing plasmid-borne NMB0419 showing significantly increased epithelial adherence compared to wild type, due to increased expression of mannose-sensitive type 1 pili...
March 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28261486/combined-inhibition-of-c5-and-cd14-efficiently-attenuated-the-inflammatory-response-in-a-porcine-model-of-meningococcal-sepsis
#17
Bernt C Hellerud, Hilde L Orrem, Knut Dybwik, Søren E Pischke, Andreas Baratt-Due, Albert Castellheim, Hilde Fure, Grethe Bergseth, Dorte Christiansen, Miles A Nunn, Terje Espevik, Corinna Lau, Petter Brandtzæg, Erik W Nielsen, Tom E Mollnes
BACKGROUND: Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key molecules of innate immunity, complement component C5, and co-receptor CD14 in the Toll-like receptor system, on the inflammatory response in meningococcal sepsis. METHODS: Meningococcal sepsis was simulated by continuous intravenous infusion of an escalating dose of heat-inactivated Neisseria meningitidis administered over 3 h...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28260146/simultaneous-detection-and-identification-of-sti-pathogens-by-multiplex-real-time-pcr-in-genital-tract-specimens-in-a-selected-area-of-apulia-a-region-of-southern-italy
#18
Raffaele Del Prete, Luigi Ronga, Mirella Lestingi, Grazia Addati, Umberto Filippo Angelotti, Domenico Di Carlo, Giuseppe Miragliotta
PURPOSE: Genital tract infections are globally a major cause of morbidity in sexually active individuals. The aim of this study was to investigate the prevalence and associations of co-infections of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma hominis (MH), Mycoplasma genitalium, Ureaplasma urealyticum (UU) and Ureaplasma parvum (UP) in specimens collected from female (SF) and male (SM) patients. METHODS: 1575 samples from 1575 individuals from the geographical area around Bari, Apulia region in Southern Italy, were collected and analyzed by a multiplex Real-Time PCR (mRT-PCR) (Anyplex(TM) II STI-7, Seegene, Inc...
March 4, 2017: Infection
https://www.readbyqxmd.com/read/28257520/lactoferrin-binding-protein-b-a-bi-functional-bacterial-receptor-protein
#19
Nicholas K H Ostan, Rong-Hua Yu, Dixon Ng, Christine Chieh-Lin Lai, Anastassia K Pogoutse, Vladimir Sarpe, Morgan Hepburn, Joey Sheff, Shaunak Raval, David C Schriemer, Trevor F Moraes, Anthony B Schryvers
Lactoferrin binding protein B (LbpB) is a bi-lobed outer membrane-bound lipoprotein that comprises part of the lactoferrin (Lf) receptor complex in Neisseria meningitidis and other Gram-negative pathogens. Recent studies have demonstrated that LbpB plays a role in protecting the bacteria from cationic antimicrobial peptides due to large regions rich in anionic residues in the C-terminal lobe. Relative to its homolog, transferrin-binding protein B (TbpB), there currently is little evidence for its role in iron acquisition and relatively little structural and biophysical information on its interaction with Lf...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28246379/the-antibiotic-resistance-crisis-with-a-focus-on-the-united-states
#20
REVIEW
Evan Martens, Arnold L Demain
Beginning with the discovery of penicillin by Alexander Fleming in the late 1920s, antibiotics have revolutionized the field of medicine. They have saved millions of lives each year, alleviated pain and suffering, and have even been used prophylactically for the prevention of infectious diseases. However, we have now reached a crisis where many antibiotics are no longer effective against even the simplest infections. Such infections often result in an increased number of hospitalizations, more treatment failures and the persistence of drug-resistant pathogens...
March 1, 2017: Journal of Antibiotics
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