keyword
MENU ▼
Read by QxMD icon Read
search

neisseria

keyword
https://www.readbyqxmd.com/read/29340331/location-specific-oral-microbiome-possesses-features-associated-with-ckd
#1
Jianzhong Hu, Srinivas Iragavarapu, Girish N Nadkarni, Ruiqi Huang, Monica Erazo, Xiuliang Bao, Divya Verghese, Steven Coca, Mairaj K Ahmed, Inga Peter
Introduction: Chronic kidney disease (CKD), a progressive loss of renal function, can lead to serious complications if underdiagnosed. Many studies suggest that the oral microbiota plays important role in the health of the host; however, little is known about the association between the oral microbiota and CKD pathogenesis. Methods: In this study, we surveyed the oral microbiota in saliva, the left and right molars, and the anterior mandibular lingual area from 77 participants (18 with and 59 without CKD), and tested their association with CKD to identify microbial features that may be predictive of CKD status...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29339382/in-vitro-susceptibility-of-neisseria-gonorrhoeae-strains-to-mupirocin-an-antibiotic-reformulated-to-parenteral-nano-liposomal-antibiotic
#2
Ahuva Cern, Kristie L Connolly, Ann E Jerse, Yechezkel Barenholz
Neisseria gonorrhoeae is an urgent antibiotic-resistant threat. This study determined the minimum inhibitory concentrations (MIC) of mupirocin to be 0.0039-0.0625 μg/ml for 94 N. gonorrhoeae strains Cross-resistance with other antibiotics was not detected.Mupirocin, currently limited to topical administration, demonstrated activity by injection when delivered in nano-liposomes. The nano-liposomal formulation of mupirocin is a potential treatment for drug-resistant N. gonorrhoeae.
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29337653/safety-and-immunogenicity-of-a-meningococcal-b-recombinant-vaccine-when-administered-with-routine-vaccines-to-healthy-infants-in-taiwan-a-phase-3-open-label-randomized-study
#3
Nan-Chang Chiu, Li-Min Huang, Arnold Willemsen, Chiranjiwi Bhusal, Ashwani Kumar Arora, Zenaida Reynoso Mojares, Daniela Toneatto
Neisseria meningitidis is associated with high mortality and morbidity in infants and children worldwide. This phase 3 study (NCT02173704) evaluated safety and immunogenicity of a 4-component serogroup B recombinant meningococcal vaccine (4CMenB) co-administered with routine vaccines in Taiwanese infants. In total, 225 healthy infants were randomized (2:1) to receive 4CMenB and routine vaccines (4CMenB+Routine) or routine vaccines only (Routine group) at 2, 4, 6 and 12 months of age. Routine vaccines were diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b, 13-valent pneumococcal, hepatitis B, measles-mumps-rubella and varicella vaccines...
January 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29336823/a-reliable-and-easy-to-transport-quality-control-method-for-chlamydia-and-gonorrhoea-molecular-point-of-care-testing
#4
S G Badman, L M Causer, R Guy, H Wand, B Donovan, S N Tabrizi, D Speers, M D Shephard, A Vallely, D Whiley
Quality control (QC) is an essential component of point-of-care testing programs. In the context of a randomised-controlled trial (TTANGO) using GeneXpert (Xpert) Chlamydia trachomatis and Neisseria gonorrhoeae (CT/NG) point-of-care testing in remote areas of Australia, we aimed to develop and utilise a stable positive control material. Bacterial cultures of CT and NG were resuspended together to provide cycle threshold (Ct) values of approximately 25 cycles for both CT and NG when tested on the Xpert CT/NG assay...
January 11, 2018: Pathology
https://www.readbyqxmd.com/read/29330894/structure-function-and-evolution-of-the-hemerythrin-like-domain-superfamily
#5
Claudia Alvarez-Carreño, Vikram Alva, Arturo Becerra, Antonio Lazcano
Hemerythrin-like proteins have generally been studied for their ability to reversibly bind oxygen through their binuclear non-heme iron centers. However, in recent years, it has become increasingly evident that some members of the hemerythrin-like superfamily also participate in many other biological processes. For instance, the binuclear non-heme iron site of YtfE, a hemerythrin-like protein involved in the repair of iron centers in Escherichia coli, catalyzes the reduction of nitric oxide to nitrous oxide, and the human F-box/LRR-repeat protein 5, which contains a hemerythrin-like domain, is involved in intracellular iron homeostasis...
January 13, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29329177/a-comparison-of-real-time-polymerase-chain-reaction-assays-for-the-detection-of-antimicrobial-resistance-markers-and-sequence-typing-from-clinical-nucleic-acid-amplification-test-samples-and-matched-neisseria-gonorrhoeae-culture
#6
Shelley W Peterson, Irene Martin, Walter Demczuk, Linda Hoang, John Wylie, Brigitte Lefebvre, Annie-Claude Labbé, Prenilla Naidu, David Haldane, Michael R Mulvey
Real-time polymerase chain reaction (PCR) assays to detect antimicrobial resistance-associated mutations were tested on Neisseria gonorrhoeae-positive clinical samples with matched isolates. Of the nucleic acid amplification tests/cultures, 87.7% (64/73), 98.6% (72/73), and 98.4% (62/63) predicted cephalosporin, ciprofloxacin, and azithromycin susceptibilities, respectively. N. gonorrhoeae multiantigen sequence type was correctly predicted for 98.7% (79/80), and 13 of 58 N. gonorrhoeae-negative specimens showed false-positive results...
February 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29329176/a-cost-analysis-of-gyrase-a-testing-and-targeted-ciprofloxacin-therapy-versus-recommended-2-drug-therapy-for-neisseria-gonorrhoeae-infection
#7
Lao-Tzu Allan-Blitz, Peera Hemarajata, Romney M Humphries, Adriane Wynn, Eddy R Segura, Jeffrey D Klausner
BACKGROUND: Novel approaches to combating drug-resistant Neisseria gonorrhoeae infections are urgently needed. Targeted therapy with ciprofloxacin has been made possible by a rapid assay for genotyping the gyrase A (gyrA) gene; a nonmutated gene reliably predicts susceptibility to ciprofloxacin. METHODS: We determined the costs of running the gyrA assay, 500 mg of ciprofloxacin, 250 mg of ceftriaxone injection, and 1000 mg of azithromycin. Cost estimates for gyrA testing included assay reagents and labor...
February 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29329168/immune-responses-to-booster-vaccination-with-meningococcal-abcwy-vaccine-following-primary-vaccination-with-either-investigational-or-licensed-vaccines-a-phase-2-randomized-study
#8
Leszek Szenborn, Stan L Block, Teresa Jackowska, Ryszard Konior, Diego DʼAgostino, Igor Smolenov, Daniela Toneatto, Jo Anne Welsch
BACKGROUND: Current meningococcal prime-boost vaccination schedules include separate vaccines for serogroups ACWY and B. An investigational combined serogroups ABCWY vaccine (MenABCWY) was developed to protect against clinically important Neisseria meningitidis serogroups. METHODS: In this phase 2, randomized, observer-blind, extension study (NCT01272180), participants aged 10-25 years received 1 booster dose of MenABCWY vaccine at 24 months (M) post-primary series of either MenABCWY (2 doses), 4CMenB (2 doses) or MenACWY-CRM vaccine (1 dose)...
January 11, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29324629/susceptibility-of-neisseria-gonorrhoeae-to-gentamicin-gonococcal-isolate-surveillance-project-2015-2016
#9
Laura M Mann, Robert D Kirkcaldy, John R Papp, Elizabeth A Torrone
The gentamicin minimum inhibitory concentrations (MICs) of Neisseria gonorrhoeae isolates were determined. Seventy-three percent of isolates demonstrated an MIC range of 8 to 16 μg/mL, and 27% demonstrated an MIC of 4 μg/mL or less. Significant associations between gentamicin MIC and resistance or reduced susceptibility to other antimicrobials were found.
February 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29321195/whole-genome-sequencing-of-the-emerging-invasive-neisseria-meningitidis-serogroup-w-in-sweden
#10
Lorraine Eriksson, Sara Thulin Hedberg, Susanne Jacobsson, Hans Fredlund, Paula Mölling, Bianca Stenmark
Invasive disease caused by Neisseria meningitidis serogroup W (MenW) has historically had a low incidence in Sweden with an average incidence of 0.03/100,000 population from 1995 to 2014. In recent years, a significant increase in incidence of MenW has been noted in Sweden to an average incidence of 0.15/100,000 population in 2015-2016. In June 2017 33% (7/21) of IMD cases were caused by MenW. In the present study, all invasive MenW isolates from Sweden collected from 1995 to June 2017 (n=86), were whole genome sequenced to determine the population structure and to compare isolates from Sweden to historical and international cases...
January 10, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29316741/association-of-salivary-microbiota-with-dental-caries-incidence-with-dentine-involvement-after-4-years
#11
Bong-Soo Kim, Dong-Hun Han, Ho Lee, Bumjo Oh
Salivary microbiota alterations can correlate with dental caries development in children,and mechanisms mediating this association need to be studied in further detail. Our study explored salivary microbiota shifts in children and their association with the incidence of dental caries with dentin involvement. Salivary samples were collected from children with caries and their subsequently matched caries-free controls before and after caries development. The microbiota was analyzed by 16S rRNA gene-based high-throughput sequencing...
January 11, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29313733/whole-blood-incubation-with-the-neisseria-meningitidis-lpxl1-mutant-induces-less-pro-inflammatory-cytokines-than-the-wild-type-and-il-10-reduces-the-myd88-dependent-cytokines
#12
Hans Christian D Aass, Marit Hellum, Anne-Marie Siebke Trøseid, Petter Brandtzaeg, Jens Petter Berg, Reidun Øvstebø, Carola Elisabeth Henriksson
Levels of bacterial LPS, pro-inflammatory cytokines and IL-10 are related to the severity of meningococcal septicaemia. Patients infected with a Neisseria meninigitidis lpxL1 mutant ( Nm-mutant) with penta-acylated lipid A present with a milder meningococcal disease than those infected with hexa-acylated Nm wild type ( Nm-wt). The aim was to compare the pro-inflammatory responses after ex vivo incubation with the heat-inactivated Nm-wt or the Nm-mutant in citrated whole blood, and the modulating effects of IL-10...
January 1, 2018: Innate Immunity
https://www.readbyqxmd.com/read/29311079/neisseria-cinerea-with-high-ceftriaxone-mic-is-an-origin-of-ceftriaxone-and-cefixime-resistance-mediating-pena-sequences-in-neisseria-gonorrhoeae
#13
Gene Igawa, Yuka Yamagishi, Ken-Ichi Lee, Misato Dorin, Ken Shimuta, Hiroyuki Suematsu, Shu-Ichi Nakayama, Hiroshige Mikamo, Magnus Unemo, Makoto Ohnishi
Mosaic penA alleles have caused most of the cephalosporin resistance in Neisseria gonorrhoeae, but their evolution is mostly unknown. The Neisseria cinerea strain AM1601 (ceftriaxone MIC=1.0 μg/ml) penA caused ceftriaxone resistance (MIC=1 μg/ml) in a ceftriaxone-susceptible gonococcal strain. The 3' -terminal half of AM1601 penA was almost identical to that of the ceftriaxone-resistant gonococcal GU140106 and FC428 strains. N. cinerea can serve as a reservoir of ceftriaxone resistance-mediating penA sequences that are transferred to gonococci...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29306437/covalent-probes-for-carbohydrate-active-enzymes-from-glycosidases-to-glycosyltransferases
#14
Yong Xu, Najib Uddin, Gerd K Wagner
Covalent probes for glycosidases and glycosyltransferases are of great interest as tool compounds for chemical biology. For glycosidases, a sizable number of such probes have been developed from covalent glycosidase inhibitors. We review selected recent examples and highlight different design strategies, including probes based on photoaffinity labels and mechanism-based inhibitors, as well as their applications in biology and for activity-based protein profiling. In contrast to glycosidases, only a limited number of covalent probes have been reported to date for glycosyltransferases...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29304758/molecular-epidemiology-of-neisseria-gonorrhoeae-strains-circulating-in-indonesia-using-multi-locus-variable-number-tandem-repeat-analysis-mlva-and-neisseria-gonorrhoeae-multi-antigen-sequence-typing-ng-mast-techniques
#15
I Putu Yuda Hananta, Alje Pieter van Dam, Maarten Franciscus Schim van der Loeff, Mirjam Dierdorp, Carolien Marleen Wind, Hardyanto Soebono, Henry John Christiaan de Vries, Sylvia Maria Bruisten
BACKGROUND: Control of gonorrhea in resource-limited countries, such as Indonesia, is mostly unsuccessful. Examining Neisseria gonorrhoeae (Ng) transmission networks using strain typing might help prioritizing public health interventions. METHODS: In 2014, urogenital Ng strains were isolated from clients of sexually transmitted infection clinics in three Indonesian cities. Strains were typed using Multiple-Locus Variable Number Tandem Repeat (VNTR) Analysis (MLVA) and Ng Multi-Antigen Sequence Typing (NG-MAST) at the Public Health Service, Amsterdam, the Netherlands, and compared to Dutch strains collected from 2012 to 2015...
January 5, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29304083/combined-evaluation-of-sexually-transmitted-infections-in-hiv-infected-pregnant-women-and-infant-hiv-transmission
#16
Kristina Adachi, Jiahong Xu, Nava Yeganeh, Margaret Camarca, Mariza G Morgado, D Heather Watts, Lynne M Mofenson, Valdilea G Veloso, Jose Henrique Pilotto, Esau Joao, Glenda Gray, Gerhard Theron, Breno Santos, Rosana Fonseca, Regis Kreitchmann, Jorge Pinto, Marisa M Mussi-Pinhata, Mariana Ceriotto, Daisy Maria Machado, Yvonne J Bryson, Beatriz Grinsztejn, Jack Moye, Jeffrey D Klausner, Claire C Bristow, Ruth Dickover, Mark Mirochnick, Karin Nielsen-Saines
BACKGROUND: Sexually transmitted infections (STIs) including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Treponema pallidum (TP), and cytomegalovirus (CMV) may lead to adverse pregnancy and infant outcomes. The role of combined maternal STIs in HIV mother-to-child transmission (MTCT) was evaluated in mother-infant pairs from NICHD HPTN 040. METHODOLOGY: Urine samples from HIV-infected pregnant women during labor were tested by polymerase chain reaction (PCR) for CT, NG, and CMV...
2018: PloS One
https://www.readbyqxmd.com/read/29297237/species-specific-differences-in-regulation-of-macrophage-inflammation-by-the-c3a-c3a-receptor-axis
#17
Tathagat Dutta Ray, Samrawit Mekasha, Yanmei Liang, Bao Lu, Sanjay Ram, Robin R Ingalls
Complement is an important arm of the innate immune system. Recent studies have shown that products of complement pathway activation can interact directly with other innate immune signaling molecules, including TLRs and inflammasome family members, during some infectious and chronic inflammatory disorders. Activation of the complement system generates anaphylatoxins, such as C3a and C5a, which modulate inflammation. However, the biological effects of interactions between the anaphylatoxins with their receptors may vary across species...
January 1, 2018: Innate Immunity
https://www.readbyqxmd.com/read/29288183/performance-of-syndromic-management-for-the-detection-and-treatment-of-genital-chlamydia-trachomatis-neisseria-gonorrhoeae-and-trichomonas-vaginalis-among-women-attending-antenatal-well-woman-and-sexual-health-clinics-in-papua-new-guinea-a-cross-sectional-study
#18
Lisa M Vallely, Pamela Toliman, Claire Ryan, Glennis Rai, Johanna Wapling, Josephine Gabuzzi, Joyce Allen, Christine Opa, Gloria Munnull, Petronia Kaima, Benny Kombuk, Antonia Kumbia, Zure Kombati, Greg Law, Angela Kelly-Hanku, Handan Wand, Peter M Siba, Glen D L Mola, John M Kaldor, Andrew J Vallely
OBJECTIVE: Papua New Guinea (PNG) has among the highest estimated prevalences of genital Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) of any country in the Asia-Pacific region. Diagnosis and treatment of these infections have relied on the WHO-endorsed syndromic management strategy that uses clinical presentation without laboratory confirmation to make treatment decisions. We evaluated the performance of this strategy in clinical settings in PNG...
December 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/29287682/development-of-an-fhbp-ctb-holotoxin-like-chimera-and-the-elicitation-of-bactericidal-antibodies-against-serogroup-b-neisseria-meningitidis
#19
Gregory A Price, Margaret C Bash
The Neisseria meningitidis factor H binding protein (FHbp) is an important virulence factor and vaccine antigen contained in both USA licensed serogroup B meningococcal vaccines. Recent studies in human factor H (hFH) transgenic mice suggest that hFH-FHbp interactions lower FHbp-elicited immunogenicity. To provide tools with which to characterize and potentially improve FHbp immunogenicity, we developed an FHbp-cholera holotoxin-like chimera vaccine expression system in Escherichia coli that utilizes cholera toxin B (CTB) as both a scaffold and adjuvant for FHbp...
December 26, 2017: Vaccine
https://www.readbyqxmd.com/read/29285017/comparative-proteomics-analysis-of-neisseria-gonorrhoeae-strains-in-response-to-extended-spectrum-cephalosporins
#20
Sunanta Nabu, Ratana Lawung, Patcharee Isarankura-Na-Ayudhya, Sittiruk Roytrakul, Supamas Dolprasit, Sineenart Sengyee, Chartchalerm Isarankura-Na-Ayudhya, Virapong Prachayasittikul
Neisseria gonorrhoeae strains displaying reduced susceptibility and resistance to extended-spectrum cephalosporins (ESCs) are major public health concerns. Although resistance mechanisms of ESCs have extensively been studied, the proteome-wide investigation on the biological response to the antibiotic stress is still limited. Herein, a proteomics approach based on two-dimensional gel electrophoresis and MALDI-TOF/TOF-MS analysis was applied to investigate the global protein expression under ESC stresses of ESC-susceptible and ESC-reduced susceptible N...
2017: EXCLI Journal
keyword
keyword
108318
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"