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https://www.readbyqxmd.com/read/27905815/medicare-program-merit-based-incentive-payment-system-mips-and-alternative-payment-model-apm-incentive-under-the-physician-fee-schedule-and-criteria-for-physician-focused-payment-models-final-rule-with-comment-period
#1
(no author information available yet)
The Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) repeals the Medicare sustainable growth rate (SGR) methodology for updates to the physician fee schedule (PFS) and replaces it with a new approach to payment called the Quality Payment Program that rewards the delivery of high-quality patient care through two avenues: Advanced Alternative Payment Models (Advanced APMs) and the Merit-based Incentive Payment System (MIPS) for eligible clinicians or groups under the PFS. This final rule with comment period establishes incentives for participation in certain alternative payment models (APMs) and includes the criteria for use by the Physician-Focused Payment Model Technical Advisory Committee (PTAC) in making comments and recommendations on physician-focused payment models (PFPMs)...
November 4, 2016: Federal Register
https://www.readbyqxmd.com/read/27900198/do-rocker-sole-shoes-influence-postural-stability-in-chronic-low-back-pain-a-randomised-trial
#2
C Sian MacRae, Duncan Critchley, Matthew Morrissey, Adam Shortland, Jeremy S Lewis
BACKGROUND: People with chronic low back pain (CLBP) demonstrate greater postural instability compared with asymptomatic individuals. Rocker-sole shoes are inherently unstable and may serve as an effective balance training device. This study hypothesised that wearing rocker-sole shoes would result in long-term improvement in barefoot postural stability in people with CLBP. METHODS: 20 participants with CLBP were randomised to wear rocker-sole or flat-sole shoes for a minimum of 2 hours each day...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27895300/thsd1-thrombospondin-type-1-domain-containing-protein-1-mutation-in-the-pathogenesis-of-intracranial-aneurysm-and-subarachnoid-hemorrhage
#3
Teresa Santiago-Sim, Xiaoqian Fang, Morgan L Hennessy, Stephen V Nalbach, Steven R DePalma, Ming Sum Lee, Steven C Greenway, Barbara McDonough, Georgene W Hergenroeder, Kyla J Patek, Sarah M Colosimo, Krista J Qualmann, John P Hagan, Dianna M Milewicz, Calum A MacRae, Susan M Dymecki, Christine E Seidman, J G Seidman, Dong H Kim
BACKGROUND AND PURPOSE: A ruptured intracranial aneurysm (IA) is the leading cause of a subarachnoid hemorrhage. This study seeks to define a specific gene whose mutation leads to disease. METHODS: More than 500 IA probands and 100 affected families were enrolled and clinically characterized. Whole exome sequencing was performed on a large family, revealing a segregating THSD1 (thrombospondin type 1 domain containing protein 1) mutation. THSD1 was sequenced in other probands and controls...
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27884928/macra-2-0-are-you-ready-for-mips
#4
REVIEW
Joshua A Hirsch, Andrew B Rosenkrantz, Sameer A Ansari, Laxmaiah Manchikanti, Gregory N Nicola
The annual cost of healthcare delivery in the USA now exceeds US$3 trillion. Fee for service methodology is often implicated as a cause of this exceedingly high figure. The Affordable Care Act created the Center for Medicare and Medicaid Innovation (CMMI) to pilot test value based alternative payments for reimbursing physician services. In 2015, the Medicare Access and CHIP Reauthorization Act (MACRA) was passed into law. MACRA has dramatic implications for all US based healthcare providers. MACRA permanently repealed the Medicare Sustainable Growth Rate so as to stabilize physician part B Medicare payments, consolidated pre-existing federal performance programs into the Merit based Incentive Payments System (MIPS), and legislatively mandated new approaches to paying clinicians...
November 24, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27880763/inhibition-of-mtor-induces-a-paused-pluripotent-state
#5
Aydan Bulut-Karslioglu, Steffen Biechele, Hu Jin, Trisha A Macrae, Miroslav Hejna, Marina Gertsenstein, Jun S Song, Miguel Ramalho-Santos
Cultured pluripotent stem cells are a cornerstone of regenerative medicine owing to their ability to give rise to all cell types of the body. Although pluripotent stem cells can be propagated indefinitely in vitro, pluripotency is paradoxically a transient state in vivo, lasting 2-3 days around the time of blastocyst implantation. The exception to this rule is embryonic diapause, a reversible state of suspended development triggered by unfavourable conditions. Diapause is a physiological reproductive strategy widely employed across the animal kingdom, including in mammals, but its regulation remains poorly understood...
December 1, 2016: Nature
https://www.readbyqxmd.com/read/27875259/monoclonal-antibodies-that-bind-to-the-ly6-domain-of-gpihbp1-abolish-the-binding-of-lpl
#6
Xuchen Hu, Mark W Sleeman, Kazuya Miyashita, MacRae F Linton, Christopher M Allan, Cuiwen He, Mikael Larsson, Yiping Tu, Norma P Sandoval, Rachel S Jung, Alaleh Mapar, Tetsuo Machida, Masami Murakami, Katsuyuki Nakajima, Michael Ploug, Loren G Fong, Stephen G Young, Anne P Beigneux
GPIHBP1, an endothelial cell protein, binds lipoprotein lipase (LPL) in the interstitial spaces and shuttles it to its site of action inside blood vessels. For years, studies of human GPIHBP1 have been hampered by an absence of useful antibodies. We reasoned that monoclonal antibodies (mAbs) against human GPIHBP1 would be useful for: (1) defining the functional relevance of GPIHBP1's Ly6 and acidic domains to the binding of LPL; (2) ascertaining whether human GPIHBP1 is expressed exclusively in capillary endothelial cells; and (3) testing whether GPIHBP1 is detectable in human plasma...
November 15, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27872323/rates-of-sexual-history-taking-and-screening-in-hiv-positive-men-who-have-sex-with-men
#7
Alasdair MacRae, Emily Lord, Annabel Forsythe, Jackie Sherrard
A case note audit was undertaken of HIV-positive men who have sex with men (MSM) to ascertain whether national guidelines for taking sexual histories, including recreational drug use and sexually transmitted infection (STI) screening were being met. The notes of 142 HIV-positive men seen in 2015 were available, of whom 85 were MSM. Information was collected regarding sexual history, recreational drug use documentation, sexually transmitted infection screen offer and test results. Seventy-seven (91%) of the MSM had a sexual history documented, of whom 60 (78%) were sexually active...
November 21, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27864567/remembering-to-learn-the-overlooked-role-of-remembrance-in-safety-improvement
#8
Carl Macrae
No abstract text is available yet for this article.
November 18, 2016: BMJ Quality & Safety
https://www.readbyqxmd.com/read/27856091/a-clinical-risk-prediction-tool-for-6-month-mortality-after-dialysis-initiation-among-older-adults
#9
James P Wick, Tanvir C Turin, Peter D Faris, Jennifer M MacRae, Robert G Weaver, Marcello Tonelli, Braden J Manns, Brenda R Hemmelgarn
BACKGROUND: Information on an individual's risk for death following dialysis therapy initiation may inform the decision to initiate maintenance dialysis for older adults. We derived and validated a clinical risk prediction tool for all-cause mortality among older adults during the first 6 months of maintenance dialysis treatment. STUDY DESIGN: Prediction model using retrospective administrative and clinical data. SETTING & PARTICIPANTS: We linked administrative and clinical data to define a cohort of 2,199 older adults (age ≥ 65 years) in Alberta, Canada, who initiated maintenance dialysis therapy (excluding acute kidney injury) in May 2003 to March 2012...
November 14, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27854190/distribution-of-the-tryptophan-pathway-derived-defensive-secondary-metabolites-gramine-and-benzoxazinones-in-poaceae
#10
Yu Kokubo, Miho Nishizaka, Naoki Ube, Yukinori Yabuta, Shin-Ichi Tebayashi, Kotomi Ueno, Shin Taketa, Atsushi Ishihara
The Poaceae is a large taxonomic group consisting of approximately 12,000 species and is classified into 12 subfamilies. Gramine and benzoxazinones (Bxs), which are biosynthesized from the tryptophan pathway, are well-known defensive secondary metabolites in the Poaceae. We analyzed the presence or absence of garamine and Bxs in 64 species in the Poaceae by LC-MS/MS. We found that Hordeum brachyantherum and Hakonechloa macra accumulated gramine, but the presence of gramine was limited to small groups of species...
November 17, 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27818407/foreword-from-acting-administrator-of-the-health-resources-and-services-administration-hrsa-and-associate-administrator-of-the-federal-office-of-rural-health-policy-forhp-u-s-department-of-health-and-human-services
#11
https://www.readbyqxmd.com/read/27811119/alcohol-consumption-and-the-risk-of-colorectal-cancer-in-mismatch-repair-gene-mutation-carriers
#12
S Ghazaleh Dashti, Daniel D Buchanan, Harindra Jayasekara, Driss Ait Ouakrim, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Finlay A Macrae, Graham G Giles, Susan Parry, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Stephen N Thibodeau, Noralane M Lindor, Polly A Newcomb, John D Potter, John A Baron, John L Hopper, Mark A Jenkins, Aung Ko Win
Background People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive. Methods 1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between alcohol consumption and colorectal cancer...
November 3, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27778204/rates-and-predictors-of-endoscopic-and-clinical-recurrence-after-primary-ileocolic-resection-for-crohn-s-disease
#13
Kyle Joshua Fortinsky, David Kevans, Judy Qiang, Wei Xu, Felipe Bellolio, Hillary Steinhart, Raquel Milgrom, Gordon Greenberg, Zane Cohen, Helen Macrae, Joanne Stempak, Robin McLeod, Mark S Silverberg
BACKGROUND AND AIMS: The utility of postoperative medical prophylaxis (POMP) and the treatment of mild endoscopic recurrence remain controversial. METHODS: This study is a retrospective review of patients undergoing a primary ileocolic resection for CD at a single academic center. Endoscopic recurrence (ER) was defined using the Rutgeerts score (RS), and clinical recurrence (CR) was defined as symptoms of CD with endoscopic or radiologic evidence of neo-terminal ileal disease...
October 24, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27775776/5-steps-to-prepare-for-macra-now
#14
Jessica Martin
As the medical community awaits the release of final rules to implement the new Medicare payment system under the Medicare Access and CHIP Reauthorization Act (MACRA), physicians can take steps now to prepare for the transition.
October 1, 2016: Texas Medicine
https://www.readbyqxmd.com/read/27773577/surgical-economics-macra-mips-and-bundles-lessons-learned-in-the-first-3%C3%A2-years-of-a-coronary-artery-bypass-grafting-alternative-payment-model
#15
Daniel T Engelman
No abstract text is available yet for this article.
September 24, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27755264/understanding-value-based-reimbursement-models-and-trends-in-orthopaedic-health-policy-an-introduction-to-the-medicare-access-and-chip-reauthorization-act-macra-of-2015
#16
Khaled J Saleh, William O Shaffer
In 2015, the US Congress passed legislation entitled the Medicare Access and CHIP [Children's Health Insurance Program] Reauthorization Act (MACRA), which led to the formation of two reimbursement paradigms: the merit-based incentive payment system (MIPS) and alternative payment models (APMs). The MACRA effectively repealed the Centers for Medicare and Medicaid Services (CMS) sustainable growth rate (SGR) formula while combining several CMS quality-reporting programs. As such, MACRA represents an unparalleled acceleration toward reimbursement models that recognize value rather than volume...
November 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/27743646/special-report-the-american-academy-of-ophthalmology-task-force-for-developing-novel-end-points-for-premium-intraocular-lenses-introduction
#17
Flora Lum, Jack T Holladay, Adrian Glasser, Scott MacRae, Samuel Masket, Walter Stark, Eva Rorer, Michelle E Tarver, Don Calogero, Gene Hilmantel, Tieuvi Nguyen, Malvina Eydelman
No abstract text is available yet for this article.
October 12, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27743645/special-report-american-academy-of-ophthalmology-task-force-recommendations-for-test-methods-to-assess-accommodation-produced-by-intraocular-lenses
#18
Adrian Glasser, Gene Hilmantel, Don Calogero, Scott MacRae, Samuel Masket, Walter Stark, Jack T Holladay, Eva Rorer, Michelle Tarver, Tieuvi Nguyen, Malvina E Eydelman
No abstract text is available yet for this article.
October 12, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27743644/special-report-american-academy-of-ophthalmology-task-force-consensus-statement-for-extended-depth-of-focus-intraocular-lenses
#19
Scott MacRae, Jack T Holladay, Adrian Glasser, Don Calogero, Gene Hilmantel, Samuel Masket, Walter Stark, Michelle E Tarver, Tieuvi Nguyen, Malvina Eydelman
No abstract text is available yet for this article.
October 12, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27742457/special-report-american-academy-of-ophthalmology-task-force-summary-statement-for-measurement-of-tilt-decentration-and-chord-length
#20
Jack T Holladay, Don Calogero, Gene Hilmantel, Adrian Glasser, Scott MacRae, Samuel Masket, Walter Stark, Michelle E Tarver, Tieuvi Nguyen, Malvina Eydelman
No abstract text is available yet for this article.
October 11, 2016: Ophthalmology
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