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https://www.readbyqxmd.com/read/28632940/characterization-of-the-i4399m-variant-of-apolipoprotein-a-implications-for-altered-prothrombotic-properties-of-lipoprotein-a
#1
Corey A Scipione, Jackson T McAiney, Daniel J Simard, Zainab A Bazzi, Matthew Gemin, Rocco Romagnuolo, Fraser L Macrae, Robert A Ariëns, Robert A Hegele, Janeen Auld, James W Gauld, Michael B Boffa, Marlys L Koschinsky
BACKGROUND: Lipoprotein(a) (Lp(a)) is a causal risk factor for a variety of cardiovascular diseases. Apolipoprotein(a) (apo(a)), the distinguishing component of Lp(a), is homologous to plasminogen, suggesting that Lp(a) can interfere with the normal fibrinolytic functions of plasminogen. This has implications for the persistence of fibrin clots in the vasculature and hence to atherothrombotic diseases. A single nucleotide polymorphism (rs3798220) in the gene encoding apo(a) has been reported that results in an Ile to Met substitution in the protease-like domain (I4399M variant)...
June 20, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28632283/the-impact-of-whole-genome-sequencing-on-the-primary-care-and-outcomes-of-healthy-adult-patients-a-pilot-randomized-trial
#2
Jason L Vassy, Kurt D Christensen, Erica F Schonman, Carrie L Blout, Jill O Robinson, Joel B Krier, Pamela M Diamond, Matthew Lebo, Kalotina Machini, Danielle R Azzariti, Dmitry Dukhovny, David W Bates, Calum A MacRae, Michael F Murray, Heidi L Rehm, Amy L McGuire, Robert C Green
Background: Whole-genome sequencing (WGS) in asymptomatic adults might prevent disease but increase health care use without clinical value. Objective: To describe the effect on clinical care and outcomes of adding WGS to standardized family history assessment in primary care. Design: Pilot randomized trial. (ClinicalTrials.gov: NCT01736566). Setting: Academic primary care practices. Participants: 9 primary care physicians (PCPs) and 100 generally healthy patients recruited at ages 40 to 65 years...
June 27, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28616688/somatic-mutations-of-the-coding-microsatellites-within-the-beta-2-microglobulin-gene-in-mismatch-repair-deficient-colorectal-cancers-and-adenomas
#3
Mark Clendenning, Alvin Huang, Harindra Jayasekara, Marie Lorans, Susan Preston, Neil O'Callaghan, Bernard J Pope, Finlay A Macrae, Ingrid M Winship, Roger L Milne, Graham G Giles, Dallas R English, John L Hopper, Aung K Win, Mark A Jenkins, Melissa C Southey, Christophe Rosty, Daniel D Buchanan
In colorectal cancers (CRCs) with tumour mismatch repair (MMR) deficiency, genes involved in the host immune response that contain microsatellites in their coding regions, including beta-2-microglobulin (B2M), can acquire mutations that may alter the immune response, tumour progression and prognosis. We screened the coding microsatellites within B2M for somatic mutations in MMR-deficient CRCs and adenomas to determine associations with tumour subtypes, clinicopathological features and survival. Incident MMR-deficient CRCs from Australasian Colorectal Cancer Family Registry (ACCFR) and the Melbourne Collaborative Cohort Study participants (n = 144) and 63 adenomas from 41 MMR gene mutation carriers from the ACCFR were screened for somatic mutations within five coding microsatellites of B2M...
June 14, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28598665/study-of-%C3%AE-and-%C3%AE-photoproduction-at-mami
#4
V L Kashevarov, P Ott, S Prakhov, P Adlarson, F Afzal, Z Ahmed, C S Akondi, J R M Annand, H J Arends, R Beck, A Braghieri, W J Briscoe, F Cividini, R Codling, C Collicott, S Costanza, A Denig, E J Downie, M Dieterle, M I Ferretti Bondy, L V Fil'kov, A Fix, S Gardner, S Garni, D I Glazier, D Glowa, W Gradl, G Gurevich, D J Hamilton, D Hornidge, D Howdle, G M Huber, A Käser, S Kay, I Keshelashvili, R Kondratiev, M Korolija, B Krusche, J Linturi, V Lisin, K Livingston, I J D MacGregor, R MacRae, J Mancell, D M Manley, P P Martel, J C McGeorge, E McNicol, D G Middleton, R Miskimen, E Mornacchi, C Mullen, A Mushkarenkov, A Neiser, M Oberle, M Ostrick, P B Otte, B Oussena, D Paudyal, P Pedroni, V V Polyanski, A Rajabi, G Reicherz, J Robinson, G Rosner, T Rostomyan, A Sarty, D M Schott, S Schumann, C Sfienti, V Sokhoyan, K Spieker, O Steffen, B Strandberg, I I Strakovsky, Th Strub, I Supek, M F Taragin, A Thiel, M Thiel, L Tiator, A Thomas, M Unverzagt, S Wagner, D P Watts, D Werthmüller, J Wettig, L Witthauer, M Wolfes, R L Workman, L Zana
The reactions γp→ηp and γp→η^{'}p are measured from their thresholds up to the center-of-mass energy W=1.96  GeV with the tagged-photon facilities at the Mainz Microtron, MAMI. Differential cross sections are obtained with unprecedented statistical accuracy, providing fine energy binning and full production-angle coverage. A strong cusp is observed in the total cross section for η photoproduction at the energies in the vicinity of the η^{'} threshold, W=1896  MeV (E_{γ}=1447  MeV). Within the framework of a revised ηMAID isobar model, the cusp, in connection with a steep rise of the η^{'} total cross section from its threshold, can only be explained by a strong coupling of the poorly known N(1895)1/2^{-} state to both ηp and η^{'}p...
May 26, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28594724/the-american-society-of-colon-and-rectal-surgeons-assessment-tool-for-performance-of-laparoscopic-colectomy
#5
Bradley J Champagne, Scott R Steele, Samantha K Hendren, Paul M Bakaki, Patricia L Roberts, Conor P Delaney, Justin T Brady, Helen M MacRae
BACKGROUND: The lack of consensus for performance assessment of laparoscopic colorectal resection is a major impediment to quality improvement. OBJECTIVE: The purpose of this study was to develop and assess the validity of an evaluation tool for laparoscopic colectomy that is feasible for wide implementation. DESIGN: During the pilot phase, a small group of experts modified previous assessment tools by watching videos for laparoscopic right colectomy with the following categories of experience: novice (less than 20 cases), intermediate (50-100 cases), and expert (more than 500 cases)...
July 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28593461/self-prioritization-and-perceptual-matching-the-effects-of-temporal-construal
#6
Marius Golubickis, Johanna K Falben, Arash Sahraie, Aleksandar Visokomogilski, William A Cunningham, Jie Sui, C Neil Macrae
Recent research has revealed that self-referential processing enhances perceptual judgments - the so-called self-prioritization effect. The extent and origin of this effect remains unknown, however. Noting the multifaceted nature of the self, here we hypothesized that temporal influences on self-construal (i.e., past/future-self continuity) may serve as an important determinant of stimulus prioritization. Specifically, as representations of the self increase in abstraction as a function of temporal distance (i...
June 7, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28590954/current-valuation-of-pathology-service
#7
Jonathan L Myles, Diana M Cardona, Todd Klemp, Ayanna Wooding, W Stephen Black-Schaffer
Health care reform has accelerated as the existing health care system undergoes continuing financial stress. Medicare's new value-based payment system, commonly referred to as MACRA, provides opportunities for physicians to participate in this new system in a variety of ways. However, many of the value-based adjustments are based on existing valuations of services through traditional mechanisms. To achieve appropriate valuation of pathologist's services in the new payment models, it is imperative that we continue to achieve proper valuation of services through the traditional mechanisms...
July 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28564684/skin-and-vascular-disease-inside-out-outside-in
#8
Calum A MacRae
No abstract text is available yet for this article.
May 31, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28551349/radiology-and-the-new-medicare-macra-patient-relationship-codes
#9
Andrew B Rosenkrantz, Joshua A Hirsch, Gregory N Nicola
No abstract text is available yet for this article.
May 24, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28545590/effect-of-climatic-variability-on-malaria-trends-in-baringo-county-kenya
#10
Edwin K Kipruto, Alfred O Ochieng, Douglas N Anyona, Macrae Mbalanya, Edna N Mutua, Daniel Onguru, Isaac K Nyamongo, Benson B A Estambale
BACKGROUND: Malaria transmission in arid and semi-arid regions of Kenya such as Baringo County, is seasonal and often influenced by climatic factors. Unravelling the relationship between climate variables and malaria transmission dynamics is therefore instrumental in developing effective malaria control strategies. The main aim of this study was to describe the effects of variability of rainfall, maximum temperature and vegetation indices on seasonal trends of malaria in selected health facilities within Baringo County, Kenya...
May 25, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28545159/the-value-transformation-of-health-care-impact-on-neuromuscular-and-electrodiagnostic-medicine
#11
Pushpa Narayanaswami, Millie Suk, Lyell K Jones
INTRODUCTION: Beginning in 2017, most physicians who participate in Medicare are subject to the Medicare Access and CHIP Reauthorization Act (MACRA), the milestone legislation that signals the US health care system's transition from volume-based to value-based care. METHODS: Review of emerging trends in development of value-based healthcare systems in the US. RESULTS: MACRA and the resulting Quality Payment Program (QPP) create two participation pathways, the Merit-based Incentive Payment System (MIPS) and the Advanced Alternative Payment Model (AAPM) pathway...
May 25, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28541417/family-history-of-atrial-fibrillation-as-a-predictor-of-atrial-substrate-and-arrhythmia-recurrence-in-patients-undergoing-atrial-fibrillation-catheter-ablation
#12
Sunil Kapur, Saurabh Kumar, Roy M John, William G Stevenson, Usha B Tedrow, Bruce A Koplan, Laurence M Epstein, Calum A MacRae, Gregory F Michaud
Aims: A commonly held notion is that patients with a family history of atrial fibrillation (AF) have worse atrial substrate and higher rates of arrhythmia recurrence following ablation. We sought to examine differences in atrial substrate and catheter ablation outcomes in patients with a 1st degree family member with paroxysmal or persistent AF (PeAF) compared to those without. Methods and results: A total of 256 consecutive patients undergoing their 1st ablation for AF (123 paroxysmal, 133 persistent) with >1 year follow up were included...
May 24, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28536768/quality-measures-and-pediatric-radiology-suggestions-for-the-transition-to-value-based-payment
#13
REVIEW
Richard E Heller, Brian D Coley, Stephen F Simoneaux, Daniel J Podberesky, Marta Hernanz-Schulman, Richard L Robertson, Lane F Donnelly
Recent political and economic factors have contributed to a meaningful change in the way that quality in health care, and by extension value, are viewed. While quality is often evaluated on the basis of subjective criteria, pay-for-performance programs that link reimbursement to various measures of quality require use of objective and quantifiable measures. This evolution to value-based payment was accelerated by the 2015 passage of the Medicare Access and CHIP (Children's Health Insurance Program) Reauthorization Act (MACRA)...
June 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28535374/discovery-of-stromal-regulatory-networks-that-suppress-ras-sensitized-epithelial-cell-proliferation
#14
Huayang Liu, James A Dowdle, Safiya Khurshid, Nicholas J Sullivan, Nicholas Bertos, Komal Rambani, Markus Mair, Piotr Daniel, Esther Wheeler, Xing Tang, Kyle Toth, Michael Lause, Markus E Harrigan, Karl Eiring, Connor Sullivan, Matthew J Sullivan, Serena W Chang, Siddhant Srivastava, Joseph S Conway, Raleigh Kladney, Joseph McElroy, Sooin Bae, Yuanzhi Lu, Ali Tofigh, Sadiq M I Saleh, Soledad A Fernandez, Jeffrey D Parvin, Vincenzo Coppola, Erin R Macrae, Sarmila Majumder, Charles L Shapiro, Lisa D Yee, Bhuvaneswari Ramaswamy, Michael Hallett, Michael C Ostrowski, Morag Park, Helen M Chamberlin, Gustavo Leone
Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a Caenorhabditis elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation of adjacent Ras pathway-sensitized epithelial cells. These candidates encode components of protein complexes and signaling pathways that converge on the control of chromatin dynamics, cytoplasmic polyadenylation, and translation...
May 22, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28527935/aca-repeal-will-not-affect-macra
#15
Caitlin W Hicks, Karen Woo, Jill Rathbun, Brad Johnson
No abstract text is available yet for this article.
June 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28527799/effect-of-yeast-supplementation-on-performance-rumination-time-and-rumen-ph-of-dairy-cows-in-commercial-farm-environments
#16
V Ambriz-Vilchis, N S Jessop, R H Fawcett, M Webster, D J Shaw, N Walker, A I Macrae
The aims of the present study were to evaluate the effects of live yeast supplementation (Vistacell MUCL 39855, AB Vista, Marlborough, UK) on performance, rumination time, and rumen pH on dairy cows in commercial farm environments. Three trials were carried out, the trials lasted 12 (trial 1), 15 (trial 2), and 19 wk (trial 3). In each trial, 14 multiparous Holstein dairy cows were allocated to 2 groups that received (trial 1) a standard diet plus yeast, (trial 2) an acidogenic diet plus yeast, and (trial 3) grazing pasture plus yeast...
July 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28522660/the-qualified-clinical-data-registry-a-pathway-to-success-within-macra
#17
M M Chen, A B Rosenkrantz, G N Nicola, E Silva, G McGinty, L Manchikanti, J A Hirsch
No abstract text is available yet for this article.
May 18, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28522650/examining-the-association-between-hemodialysis-access-type-and-mortality-the-role-of-access-complications
#18
Pietro Ravani, Robert Quinn, Matthew Oliver, Bruce Robinson, Ronald Pisoni, Neesh Pannu, Jennifer MacRae, Braden Manns, Brenda Hemmelgarn, Matthew James, Marcello Tonelli, Brenda Gillespie
BACKGROUND AND OBJECTIVES: People receiving hemodialysis to treat kidney failure need a vascular access (a fistula, a graft, or a central venous catheter) to connect to the blood purification machine. Higher rates of access complications are considered the mechanism responsible for the excess mortality observed among catheter or graft users versus fistula users. We tested this hypothesis using mediation analysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We studied incident patients who started hemodialysis therapy from North America, Europe, and Australasia (the Dialysis Outcomes and Practice Patterns Study; 1996-2011)...
June 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28505630/macra-big-fix-or-big-problem
#19
J Michael McWilliams
No abstract text is available yet for this article.
May 16, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28492008/physician-industry-collaboration-organizational-considerations-for-the-future-of-innovation-and-growth-in-dermatology
#20
EDITORIAL
Wendy E Roberts, Neil S Sadick, Wilma F Bergfeld, Amy S Paller, Valerie D Callender, Lynn A Drake
The U.S. medical environment continues to evolve with issues from Privacy to EMR, Insurance regulations, Physician Access and Healthcare Reform, and MACRA (Medicare Access and CHIP Reauthorization Act) on the discussion table. Not since the advent of Medicare and Medicaid in the mid 1960's, have we seen such widespread changes in the medical healthcare environment (Centers for Medicare and Medicaid Services). Physicians, industry, patients and consumers are affected by the changes. These four groups have historically worked as separate entities, but are now key stakeholders in the future of dermatology...
June 2016: International Journal of Women's Dermatology
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