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https://www.readbyqxmd.com/read/29331506/hepatocyte-estrogen-receptor-alpha-mediates-estrogen-action-to-promote-reverse-cholesterol-transport-during-western-type-diet-feeding
#1
Lin Zhu, Jeanne Shi, Thao N Luu, Joshua C Neuman, Elijah Trefts, Sophia Yu, Brian T Palmisano, David H Wasserman, MacRae F Linton, John M Stafford
OBJECTIVE: Hepatocyte deletion of estrogen receptor alpha (LKO-ERα) worsens fatty liver, dyslipidemia, and insulin resistance in high-fat diet fed female mice. However, whether or not hepatocyte ERα regulates reverse cholesterol transport (RCT) in mice has not yet been reported. METHODS AND RESULTS: Using LKO-ERα mice and wild-type (WT) littermates fed a Western-type diet, we found that deletion of hepatocyte ERα impaired in vivo RCT measured by the removal of 3H-cholesterol from macrophages to the liver, and subsequently to feces, in female mice but not in male mice...
December 29, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29319409/occupational-therapy-essentials-for-clinical-competenceby-karen-jacobs-nancy-macrae-slack-incorporated-6900-grove-road-thorofare-nj-08086-856-848-1000-price-99-95-isbn-9781630912475
#2
https://www.readbyqxmd.com/read/29314812/making-sense-of-macra-in-2018-six-things-you-need-to-know
#3
Amy Mullins
No abstract text is available yet for this article.
January 2018: Family Practice Management
https://www.readbyqxmd.com/read/29312866/quantitative-texture-analysis-on-pre-treatment-computed-tomography-predicts-local-recurrence-in-stage-i-non-small-cell-lung-cancer-following-stereotactic-radiation-therapy
#4
Carole Dennie, Rebecca Thornhill, Carolina A Souza, Cecilia Odonkor, Jason R Pantarotto, Robert MacRae, Graham Cook
Background: The prediction of local recurrence (LR) of stage I non-small cell lung cancer (NSCLC) after definitive stereotactic body radiotherapy (SBRT) remains elusive. The purpose of this study was to assess whether quantitative imaging features on pre-treatment computed tomography (CT) can predict LR beyond 18 (18F) fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT maximum standard uptake value (SUVmax). Methods: This retrospective study evaluated 36 patients with 37 stage I NSCLC who had local tumor control (LC; n=19) and (LR; n=18)...
December 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29304429/mechanical-behaviour-of-alginate-gelatin-hydrogels-for-3d-bioprinting
#5
Michael Di Giuseppe, Nicholas Law, Braeden Webb, Ryley A Macrae, Lawrence J Liew, Timothy B Sercombe, Rodney J Dilley, Barry J Doyle
Hydrogels comprised of alginate and gelatin have demonstrated potential as biomaterials in three dimensional (3D) bioprinting applications. However, as with all hydrogel-based biomaterials used in extrusion-based bioprinting, many parameters influence their performance and there is limited data characterising the behaviour of alginate-gelatin (Alg-Gel) hydrogels. Here we investigated nine Alg-Gel blends by varying the individual constituent concentrations. We tested samples for printability and print accuracy, compressive behaviour and change over time, and viability of encapsulated mesenchymal stem cells in bioprinted constructs...
December 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29286439/isolation-and-characterization-of-primary-rat-valve-interstitial-cells-a-new-model-to-study-aortic-valve-calcification
#6
Cui Lin, Dongxing Zhu, Greg Markby, Brendan M Corcoran, Colin Farquharson, Vicky E Macrae
Calcific aortic valve disease (CAVD) is characterized by the progressive thickening of the aortic valve leaflets. It is a condition frequently found in the elderly and end-stage renal disease (ESRD) patients, who commonly suffer from hyperphosphatemia and hypercalcemia. At present, there are no medication therapies that can stop its progression. The mechanisms that underlie this pathological process remain unclear. The aortic valve leaflet is composed of a thin layer of valve endothelial cells (VECs) on the outer surfaces of the aortic cusps, with valve interstitial cells (VICs) sandwiched between the VECs...
November 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29282080/safety-analysis-over-time-seven-major-changes-to-adverse-event-investigation
#7
Charles Vincent, Jane Carthey, Carl Macrae, Rene Amalberti
BACKGROUND: Every safety-critical industry devotes considerable time and resource to investigating and analysing accidents, incidents and near misses. The systematic analysis of incidents has greatly expanded our understanding of both the causes and prevention of harm. These methods have been widely employed in healthcare over the last 20 years but are now subject to critique and reassessment. In this paper, we reconsider the purpose and value of incident analysis and methods appropriate to the healthcare of today...
December 28, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29275918/double-scan-ct-rates-an-opportunity-for-facility-based-radiologist-measures-in-the-quality-payment-program
#8
Andrew B Rosenkrantz, James S Babb, Gregory N Nicola, Ezequiel Silva, Wenyi Wang, Richard Duszak
PURPOSE: The Medicare Access and CHIP Reauthorization Act (MACRA) provides CMS flexibility to evaluate radiologists using hospital outpatient quality measures in place of conventional physician measures. We explore radiologist characteristics associated with variation in performance in two such measures: abdomen and chest CT "double scan" rates (percentage of total examinations performed both with and without intravenous contrast). METHODS: Radiologists' claims for abdomen and chest CT examinations in a facility setting were identified using 2014 Medicare Physician and Other Supplier data...
December 21, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29248103/preparing-for-the-outpatient-treatment-of-venous-disease-under-macra
#9
Steven A Leers, Karen Woo, Jill Rathbun, Brad Johnson
No abstract text is available yet for this article.
January 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29246924/the-prothrombotic-state-in-paroxysmal-nocturnal-haemoglobinuria-a-multifaceted-source
#10
Barnaby Peacock-Young, Fraser L Macrae, Darren J Newton, Anita Hill, Robert A S Ariëns
Paroxysmal nocturnal haemoglobinuria is a rare acquired haematological disorder, the most serious complication of which is thrombosis. The increased incidence of thrombosis in paroxysmal nocturnal haemoglobinuria is still poorly understood, but unlike many other thrombotic disorders, predominantly involves complement mediated mechanisms. This review article discusses the different factors that contribute to the increased risk of thrombosis in paroxysmal nocturnal haemoglobinuria. Paroxysmal nocturnal haemoglobinuria leads to a complex and multifaceted prothrombotic state due to the pathological effects of platelet activation, intravascular haemolysis and neutrophil/monocyte activation...
December 15, 2017: Haematologica
https://www.readbyqxmd.com/read/29234722/physician-industry-collaboration-organizational-considerations-for-the-future-of-innovation-and-growth-in-dermatology
#11
EDITORIAL
Wendy E Roberts, Neil S Sadick, Wilma F Bergfeld, Amy S Paller, Valerie D Callender, Lynn A Drake
The U.S. medical environment continues to evolve with issues from Privacy to EMR, Insurance regulations, Physician Access and Healthcare Reform, and MACRA (Medicare Access and CHIP Reauthorization Act) on the discussion table. Not since the advent of Medicare and Medicaid in the mid 1960's, have we seen such widespread changes in the medical healthcare environment (Centers for Medicare and Medicaid Services). Physicians, industry, patients and consumers are affected by the changes. These four groups have historically worked as separate entities, but are now key stakeholders in the future of dermatology...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29232069/medicare-program-cy-2018-updates-to-the-quality-payment-program-and-quality-payment-program-extreme-and-uncontrollable-circumstance-policy-for-the-transition-year-final-rule-with-comment-period-and-interim-final-rule-with-comment-period
#12
(no author information available yet)
The Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) established the Quality Payment Program for eligible clinicians. Under the Quality Payment Program, eligible clinicians can participate via one of two tracks: Advanced Alternative Payment Models (APMs); or the Merit-based Incentive Payment System (MIPS). We began implementing the Quality Payment Program through rulemaking for calendar year (CY) 2017. This final rule with comment period provides updates for the second and future years of the Quality Payment Program...
November 16, 2017: Federal Register
https://www.readbyqxmd.com/read/29223955/high-density-lipoprotein-cholesterol-concentration-and-acute-kidney-injury-after-cardiac-surgery
#13
Loren E Smith, Derek K Smith, Jeffrey D Blume, MacRae F Linton, Frederic T Billings
BACKGROUND: Acute kidney injury (AKI) after cardiac surgery is associated with increased short- and long-term mortality. Inflammation, oxidative stress, and endothelial dysfunction and damage play important roles in the development of AKI. High-density lipoproteins (HDLs) have anti-inflammatory and antioxidant properties and improve endothelial function and repair. Statins enhance HDL's anti-inflammatory and antioxidant capacities. We hypothesized that a higher preoperative HDL cholesterol concentration is associated with decreased AKI after cardiac surgery and that perioperative statin exposure potentiates this association...
December 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29218995/enantioselective-synthesis-of-spliceostatin-g-and-evaluation-of-bioactivity-of-spliceostatin-g-and-its-methyl-ester
#14
Arun K Ghosh, Guddeti Chandrashekar Reddy, Andrew J MacRae, Melissa S Jurica
An enantioselective total synthesis of spliceostatin G has been accomplished. The synthesis involved a Suzuki cross-coupling reaction as a key step. The functionalized tetrahydropyran ring was constructed from commercially available optically active tri-O-acetyl-d-glucal. Other key reactions include a highly stereoselective Claisen rearrangement, a Cu(I)-mediated 1,4 addition of MeLi to install the C8 methyl group, and a reductive amination to incorporate the C10 amine functionality of spliceostatin G. Biological evaluation of synthetic spliceostatin G and its methyl ester revealed that it does not inhibit splicing in vitro...
December 8, 2017: Organic Letters
https://www.readbyqxmd.com/read/29207136/exploiting-novel-valve-interstitial-cell-lines-to-study-calcific-aortic-valve-disease
#15
Hiu-Gwen Tsang, Lin Cui, Colin Farquharson, Brendan M Corcoran, Kim M Summers, Vicky E Macrae
Calcific aortic valve disease (CAVD) involves progressive valve leaflet thickening and severe calcification, impairing leaflet motion. The in vitro calcification of primary rat, human, porcine and bovine aortic valve interstitial cells (VICs) is commonly employed to investigate CAVD mechanisms. However, to date, no published studies have utilised cell lines to investigate this process. The present study has therefore generated and evaluated the calcification potential of immortalized cell lines derived from sheep and rat VICs...
November 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29203760/developing-a-framework-for-evaluating-the-impact-of-healthcare-improvement-science-education-across-europe-a-qualitative-study
#16
Manuel Lillo-Crespo, M Cristina Sierras-Davó, Rhoda MacRae, Kevin Rooney
Purpose: Frontline healthcare professionals are well positioned to improve the systems in which they work. Educational curricula, however, have not always equipped healthcare professionals with the skills or knowledge to implement and evaluate improvements. It is important to have a robust and standardized framework in order to evaluate the impact of such education in terms of improvement, both within and across European countries. The results of such evaluations will enhance the further development and delivery of Healthcare Improvement Science (HIS) education...
November 29, 2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/29182882/when-no-news-is-bad-news-communication-failures-and-the-hidden-assumptions-that-threaten-safety
#17
Carl Macrae
No abstract text is available yet for this article.
January 1, 2017: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/29172697/what-are-dementia-champions-and-why-do-we-need-them
#18
Margaret Brown, Anna Waugh, Barbara Sharp, Raymond Fj Duffy, Rhoda MacRae
No abstract text is available yet for this article.
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29167859/challenges-perceptions-and-readiness-of-oncology-clinicians-for-the-macra-quality-payment-program
#19
Chadi Nabhan, Yolaine Jeune-Smith, Peter Klinefelter, Ronan J Kelly, Bruce A Feinberg
No abstract text is available yet for this article.
November 22, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29163144/the-relationship-of-cognitive-performance-and-the-theta-alpha-power-ratio-is-age-dependent-an-eeg-study-of-short-term-memory-and-reasoning-during-task-and-resting-state-in-healthy-young-and-old-adults
#20
Janet P Trammell, Priscilla G MacRae, Greta Davis, Dylan Bergstedt, Ariana E Anderson
Objective: The Theta-Alpha ratio (TAR) is known to differ based upon age and cognitive ability, with pathological electroencephalography (EEG) patterns routinely found within neurodegenerative disorders of older adults. We hypothesized that cognitive ability would predict EEG metrics differently within healthy young and old adults, and that healthy old adults not showing age-expected EEG activity may be more likely to demonstrate cognitive deficits relative to old adults showing these expected changes. Methods: In 216 EEG blocks collected in 16 young and 20 old adults during rest (eyes open, eyes closed) and cognitive tasks (short-term memory [STM]; matrix reasoning [RM; Raven's matrices]), models assessed the contributing roles of cognitive ability, age, and task in predicting the TAR...
2017: Frontiers in Aging Neuroscience
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