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https://www.readbyqxmd.com/read/28817575/mck1-is-a-novel-regulator-of-myo-inositol-phosphate-synthase-mips-that-is-required-for-inhibition-of-inositol-synthesis-by-the-mood-stabilizer-valproate
#1
Wenxi Yu, Joshua Daniel, Dhara Mehta, Krishna Rao Maddipati, Miriam L Greenberg
Myo-inositol, the precursor of all inositol compounds, is essential for the viability of eukaryotes. Identifying the factors that regulate inositol homeostasis is of obvious importance to understanding cell function and the pathologies underlying neurological and metabolic resulting from perturbation of inositol metabolism. The current study identifies Mck1, a GSK3 homolog, as a novel positive regulator of inositol de novo synthesis in yeast. Mck1 was required for normal activity of myo-inositol phosphate synthase (MIPS), which catalyzes the rate-limiting step of inositol synthesis...
2017: PloS One
https://www.readbyqxmd.com/read/28815273/micro-versus-nano-sized-molecularly-imprinted-polymers-in-maldi-tof-mass-spectrometry-analysis-of-peptides
#2
Lucia Cenci, Maddalena Bertolla, Andrea Anesi, Emmanuele Ambrosi, Graziano Guella, Alessandra Maria Bossi
The integration of molecularly imprinted polymers (MIPs) with MALDI-TOF mass spectrometry (MS) combines MIP selectivity with MS sensitivity. Whether the size of the MIP material-micro versus nano-has an effect on the MS analysis was the object of the study. MIPs, targeting respectively the epitope peptide NR11 of cardiac troponin I and the peptide CK13 of human serum transferrin, were synthesized and characterized. The size-related performance of the MIP materials hyphenated with MALDI-TOF-MS analysis was studied by the incubation of the target peptide with the respective micro- or nano-MIP, followed by rinsing to remove non-specific deposition of the MIP to the MALDI target plate, co-crystallization with the organic matrix, and mass analysis...
August 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28813495/establishing-failure-predictors-for-the-planned-extubation-of-overweight-and-obese-patients
#3
Chien-Ming Chao, Chih-Cheng Lai, Ai-Chin Cheng, Shyh-Ren Chiang, Wei-Lun Liu, Chung-Han Ho, Shu-Chen Hsing, Chin-Ming Chen, Kuo-Chen Cheng
We investigated failure predictors for the planned extubation of overweight (body mass index [BMI] = 25.0-29.9) and obese (BMI ≥ 30) patients. All patients admitted to the adult intensive care unit (ICU) of a tertiary hospital in Taiwan were identified. They had all undergone endotracheal intubation for > 48 h and were candidates for extubation. During the study, 595 patients (overweight = 458 [77%]); obese = 137 [23%]) with planned extubation after weaning were included in the analysis; extubation failed in 34 patients (5...
2017: PloS One
https://www.readbyqxmd.com/read/28813018/biophysical-and-computational-studies-of-the-vcci-vmip-ii-complex
#4
Anna F Nguyen, Nai-Wei Kuo, Laura J Showalter, Ricardo Ramos, Cynthia M Dupureur, Michael E Colvin, Patricia J LiWang
Certain viruses have the ability to subvert the mammalian immune response, including interference in the chemokine system. Poxviruses produce the chemokine binding protein vCCI (viral CC chemokine inhibitor; also called 35K), which tightly binds to CC chemokines. To facilitate the study of vCCI, we first provide a protocol to produce folded vCCI from Escherichia coli (E. coli.) It is shown here that vCCI binds with unusually high affinity to viral Macrophage Inflammatory Protein-II (vMIP-II), a chemokine analog produced by the virus, human herpesvirus 8 (HHV-8)...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28812173/melatonin-attenuates-pain-hypersensitivity-and-decreases-astrocyte-mediated-spinal-neuroinflammation-in-a-rat-model-of-oxaliplatin-induced-pain
#5
Ye-Song Wang, Yuan-Yuan Li, Wei Cui, Li-Bin Li, Zhao-Cai Zhang, Bao-Ping Tian, Gen-Sheng Zhang
Neuroinflammatory response in spinal dorsal horn has been demonstrated to be a critical factor in oxaliplatin-induced pain. Melatonin has been shown to have anti-inflammatory and anti-allodynia effects in both preclinical and clinical studies. In the present study, we investigated the role of systemic administration of melatonin on oxaliplatin-induced pain. Intraperitoneal (i.p.) injection with oxaliplatin induced significantly mechanical allodynia and thermal hyperalgesia. Melatonin (i.p.) significantly alleviated mechanical allodynia and thermal hyperalgesia in the oxaliplatin but not sham-treated rats...
August 15, 2017: Inflammation
https://www.readbyqxmd.com/read/28806526/highly-selective-self-powered-sensing-platform-for-p-nitrophenol-detection-constructed-with-a-photocathode-based-photocatalytic-fuel-cell
#6
Kai Yan, Yaohua Yang, Yuhan Zhu, Jingdong Zhang
A photocathode-based photocatalytic fuel cell (PFC) was fabricated and proposed as a self-powered sensor for p-nitrophenol (p-NP) detection. The PFC was comprised of a photocathode and an anode in separated chambers, which could generate suitable power output under photoirradiation to drive the sensing process. In this device, p-type PbS quantum dots-modified glass carbon electrode (GCE) served as the photocathode for the reduction of p-NP under photoirradiation while graphene-modified GCE was employed as the anode for the oxidation of ascorbic acid...
August 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28805233/analytic-and-dynamic-secretory-profile-of-patient-derived-cytokine-induced-killer-cells
#7
Giulia Mesiano, Roberta Zini, Giulia Montagner, Nicoletta Bianchi, Rossella Manfredini, Antonella Chillemi, Massimo Aglietta, Giovanni Grignani, Ilaria Lampronti, Erika Fiorino, Fabio Malavasi, Dario Sangiolo, Roberto Gambari, Davide Ferrari
Adoptive immunotherapy with Cytokine Induced Killer (CIK) cells has shown antitumor activity against several kinds of cancers in preclinical models and clinical trials. CIK cells are a subset of ex vivo expanded T lymphocytes with T-NK phenotype and MHC-unrestricted antitumor activity. Literature provides scanty information on cytokines, chemokines and growth factors secreted by CIK cells. Therefore, we investigated the secretory profile of CIK cells generated from tumor patients. The secretome analysis was performed at specific time points (day 1, day 14 and day 21) of CIK cells expansion...
August 9, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/28803116/efficient-molecularly-imprinted-polymer-as-a-pipette-tip-solid-phase-sorbent-for-determination-of-carvedilol-enantiomers-in-human-urine
#8
Anny Talita Maria da Silva, Hanna Leijoto de Oliveira, Camilla Fonseca Silva, Matheus Cecílio Fonseca, Thales Fernando Dias Pereira, Clebio Soares Nascimento, Eduardo Costa de Figueiredo, Keyller Bastos Borges
In this work, an efficient pipette tip based on molecularly imprinted polymers solid-phase extraction (PT-MIP-SPE) method was developed for carvedilol (CAR) analysis. This compound is available in clinical practice as a racemic mixture, in which (-)-(S)-CAR is a β- and α1-adrenergic antagonist, while (+)-(R)-CAR only acts as an α1-adrenergic antagonist. Enantioseparation of CAR presented satisfactory retention times (5.85 and 14.84min), acceptable theoretical plates (N=2048 and 2018) and good resolution (Rs=9...
August 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28801293/-effect-of-macrophage-inflammatory-protein-1%C3%AE-on-proliferation-and-apoptosis-of-human-tongue-squamous-cell-carcinoma-cal-27-cells-in-vitro
#9
Bo Jia, Xiao-Ling Qiu, Hong-Xing Chu, Xiang Sun, Jie Pan, Zhi-Ping Wang, Jian-Jiang Zhao
OBJECTIVE: To detect CCR5 protein expression in different human tongue squamous cell carcinoma cells and observe the effect of macrophage inflammatory protein-1β (MIP-1β) on the proliferation and apoptosis of CAL-27 cells. METHODS: Western blotting and immunofluorescence staining were used to detect the expression of the CCR5, the receptor of MIP-1β, in 3 human tongue squamous cell carcinoma cells UM-1, CAL-27, and Tca-8113. CCK-8 assay was used to assess the proliferation of CAL-27 cells stimulated with 10, 20, and 40 ng/mL MIP-1β for 12, 24, or 48 h...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28798219/improved-detection-of-anterior-circulation-occlusions-the-delayed-vessel-sign-on-multiphase-ct-angiography
#10
D Byrne, G Sugrue, E Stanley, J P Walsh, S Murphy, E C Kavanagh, P J MacMahon
BACKGROUND AND PURPOSE: Multiphase CTA, a technique to dynamically assess the vasculature in acute ischemic stroke, was primarily developed to evaluate collateral filling. We have observed that it is also useful in identifying distal anterior circulation occlusions due to delayed anterior circulation opacification on multiphase CTA, an observation we term the "delayed vessel sign." We aimed to determine the usefulness of this sign by comparing multiphase CTA with single-phase CTA. MATERIALS AND METHODS: All 23 distal anterior circulation occlusions during a 2-year period were included...
August 10, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28794334/development-and-applications-of-quantum-dot-based-molecularly-imprinted-polymer-composites-for-optosensing-of-carbofuran-in-water
#11
Qiang Zhou, Chengcheng Liu, Hong Zhang, Chunjie Zhao, Yanhong Wang
In this paper, quantum dot (QD)-based molecularly imprinted polymer (MIP) was fabricated and successfully utilized as a fluorescent probe for highly selective and sensitive detection of carbofuran in water samples. The MIPs were synthesized followed by a multi-step swelling and polymerization method, and then labeled with CdSe/ZnS QDs via gradual solvent evaporation. Then the prepared QDs-MIP microspheres were introduced to flow cytometry by virtue of their good dispersibility in water, and fast adsorption and desorption...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28793351/characterization-of-neurons-in-the-primate-medial-intraparietal-area-reveals-a-joint-representation-of-intended-reach-direction-and-amplitude
#12
Rishi Rajalingham, Sam Musallam
To support accurate memory-guided reaching, the brain must represent both the direction and amplitude of reaches in a movement plan. Several cortical areas have been shown to represent the direction of a planned reaching movement, but the neuronal representation of reach amplitude is still unclear, especially in sensory-motor integration areas. To investigate this, we recorded from neurons in the medial intraparietal area (MIP) of monkeys performing a variable amplitude memory reach task. In one monkey, we additionally recorded from the dorsal premotor cortex (PMd) for direct cross-area comparisons...
2017: PloS One
https://www.readbyqxmd.com/read/28791744/assessment-of-the-imprinting-efficiency-of-an-imide-with-a-stoichiometric-pyridine-based-functional-monomer-in-precipitation-polymerisation
#13
K Fremielle Lim, Andrew J Hall, Stefania Lettieri, Clovia I Holdsworth
The efficiency of the stoichiometric non-covalent imprinting of the imide 2,3,5-tri-O-acetyluridine (TAU) with 2,6-bis(acrylamido)pyridine (BAAPy) as functional monomer due to their strong donor-acceptor-donor/acceptor-donor-acceptor (DAD/ADA) hydrogen bond array interaction has been evaluated by bulk imprinting. This study is the first to investigate the imprinting and template rebinding efficiencies of the TAU/BAAPy molecularly imprinted polymeric (MIP) system prepared by precipitation polymerisation. We found that the stoichiometric 1:1 T:FM ratio has not been maintained in precipitation polymerisation and an optimal TAU:BAAPy ratio of 1:2...
August 9, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28789799/subcritical-water-extraction-combined-with-molecular-imprinting-technology-for-sample-preparation-in-the-detection-of-triazine-herbicides
#14
Fengnian Zhao, Shanshan Wang, Yongxin She, Chao Zhang, Lufei Zheng, Maojun Jin, Hua Shao, Fen Jin, Xinwei Du, Jing Wang
A selective, environmentally friendly, and cost-effective sample extraction method based on a combination of subcritical water extraction (SWE) and molecularly imprinted solid-phase extraction (MISPE) was developed for the determination of eight triazine herbicides in soil samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS). In SWE, the highest extraction yields of triazine herbicides were obtained under 150°C for 15min using 20% ethanol as the organic modifier. Addition of MIP during SWE increased the extraction efficiency, and using MIP as a selective SPE sorbent improved the enrichment capability...
July 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28780460/nanoscale-trifunctional-bovine-hemoglobin-for-fabricating-molecularly-imprinted-polydopamine-via-pickering-emulsions-hydrogels-polymerization
#15
Yanhua Sun, Shian Zhong
In this work, a novel strategy was developed for the selective recognition of protein based on oil-in-water Pickering emulsions-hydrogels polymerization and interfacial imprinting method. For the first time, nanoscale trifunctional bovine hemoglobin (BHb) played three roles simultaneously during the process, including emulsifier, template protein and sacrificial material for further exposing recognition sites. Prior to acting as stabilizers, bovine hemoglobin colloidal particles (BCPs) were firstly prepared by acidification and heat denaturation...
July 29, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28780140/synthesis-of-polymeric-monoliths-via-thiol-maleimide-polymerization-reaction-for-highly-efficient-chromatographic-separation
#16
Jingyao Bai, Junjie Ou, Haiyang Zhang, Shujuan Ma, Yehua Shen, Mingliang Ye
One-step thiol-maleimide polymerization reaction was firstly adopted for direct preparation of polymeric monoliths via alkaline-catalyzed reaction of 4,4'-bis(maleimidophenyl)methane (BMI) and trimethylolpropane tris(3-mercaptopropionate) (3SH)/pentaerythriol tetra(3-mercaptopropionate) (4SH) in the presence of a small amount of triethylamine (TEA). The polymerization could be performed within 3h, which was faster than thermal-initiated free radical polymerization. Two kinds of monoliths, poly(BMI-co-3SH) (marked as I) and poly(BMI-co-4SH) (marked as II), were characterized with scanning electron microscopy (SEM), attenuated total reflection Fourier-transformed infrared spectroscopy (ATR-FTIR), thermal gravimetric analysis (TGA) and mercury intrusion porosimetry (MIP)...
July 26, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28778030/development-and-application-of-a-novel-fluorescent-nanosensor-based-on-fese-quantum-dots-embedded-silica-molecularly-imprinted-polymer-for-the-rapid-optosensing-of-cyfluthrin
#17
Xunjia Li, Hai-Feng Jiao, Xi-Zhi Shi, Aili Sun, Xiujuan Wang, Jiye Chai, De-Xiang Li, Jiong Chen
A novel molecularly imprinted silica layer appended to FeSe quantum dots (MIP-FeSe-QDs) was fabricated and utilized as a recognition element to develop a selective and sensitive fluorescent nanosensor for cyfluthrin (CYF) determination. The MIP-FeSe-QDs were characterized by fluorescence spectrometry, scanning electron microscopy, transmission electron microscopy, and Fourier transform infrared spectroscopy. Excellent selectivity and high sensitivity of MIP-FeSe-QDs to CYF molecules were observed based on the fluorescence quenching of FeSe-QDs...
July 29, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28777750/polymorphonuclear-neutrophil-functions-are-differentially-altered-in-amnestic-mild-cognitive-impairment-and-mild-alzheimer-s-disease-patients
#18
Aurélie Le Page, Julie Lamoureux, Karine Bourgade, Eric H Frost, Graham Pawelec, Jacek M Witkowski, Anis Larbi, Gilles Dupuis, Tamàs Fülöp
The mechanisms of neurodegeneration in Alzheimer's disease (AD) remain under investigations. Alterations in the blood-brain barrier facilitate exchanges of inflammatory mediators and immune cells between the brain and the periphery in AD. Here, we report analysis of phenotype and functions of polymorphonuclear neutrophils (PMN) in peripheral blood in amnestic mild cognitive impairment (aMCI, n = 13), patients with mild AD (mAD, n = 15), and healthy elderly controls (n = 13). Results showed an increased expression of CD177 in mAD but not in healthy or aMCI patients...
July 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28773964/modification-of-lightweight-aggregates-microstructure-by-used-motor-oil-addition
#19
Małgorzata Franus, Grzegorz Jozefaciuk, Lidia Bandura, Krzysztof Lamorski, Mieczysław Hajnos, Wojciech Franus
An admixture of lightweight aggregate substrates (beidellitic clay containing 10 wt % of natural clinoptilolite or Na-P1 zeolite) with used motor oil (1 wt %-8 wt %) caused marked changes in the aggregates' microstructure, measured by a combination of mercury porosimetry (MIP), microtomography (MT), and scanning electron microscopy. Maximum porosity was produced at low (1%-2%) oil concentrations and it dropped at higher concentrations, opposite to the aggregates' bulk density. Average pore radii, measured by MIP, decreased with an increasing oil concentration, whereas larger (MT) pore sizes tended to increase...
October 18, 2016: Materials
https://www.readbyqxmd.com/read/28772867/influence-of-emulsified-asphalt-on-the-mechanical-property-and-microstructure-of-cement-stabilized-gravel-under-freezing-and-thawing-cycle-conditions
#20
Yiqi Wang, Yiqiu Tan, Meng Guo, Xinglong Wang
Properties of cement-stabilized gravel modified by emulsified asphalt under freezing and thawing cycle conditions were investigated by adjusting the dosage of cement. Mercury intrusion porosimetry (MIP) and Scanning electron microscopy (SEM) were introduced to analyze the influential mechanism. The results indicate that cement emulsified asphalt stabilized gravel with 5 wt % of cement performed well in both mechanics and frost-resistance. Although the addition of emulsified asphalt would lead to a partial decrease of strength, it can extend the process of strength loss and improve the freezing resistance...
May 6, 2017: Materials
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