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Dongping Ye, Weiguo Liang, Libing Dai, Yicun Yao
We first applied moderate fluid shear stress to nucleus pulposus cells. The correlation of AP-1 with type II collagen, proteoglycan, Cytokeratin 8 protein, MAP-1, MAP-2, and MAP-4 and the correlation of AP-1 with IL-1 β , TNF- α , IL-6, IL-8, MIP-1, MCP-1, and NO were detected. Our results document that moderate fluid shear stress could activate the FAK-MEK5-ERK5-cFos-AP1 signaling pathway. AP1 could downregulate the construct factors of cytoskeleton such as type II collagen, proteoglycan, Cytokeratin 8 protein, MAP-1, MAP-2, and MAP-4 in nucleus pulposus cell after the fluid shear stress was loaded...
2018: Disease Markers
Ria Mulherkar, Aykan Karabudak, Rashida Ginwala, Xiaofang Huang, Aileen Rowan, Ramila Philip, Edward L Murphy, Danielle Clements, Lishomwa C Ndhlovu, Zafar K Khan, Pooja Jain
Human T-cell leukemia virus type 1 (HTLV-1) has infected as many as 10 million people worldwide. While 90% are asymptomatic, 5% develop severe diseases including adult T-cell leukemia/lymphoka (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). No vaccine against HTLV-1 exists, and screening programs are not universal. However, patients with chronic HTLV-1 infection have high frequencies of HTLV-1-activated CD8+ T cells, and the two main HLA alleles (A2, A24) are present in 88% of infected individuals...
July 10, 2018: Vaccine
Daniel Wolf, René Hübner, Tore Niermann, Sebastian Sturm, Paola Prete, Nicola Lovergine, Bernd Buechner, Axel Lubk
The non-destructive characterization of nanoscale devices, such as those based on semiconductor nanowires, in terms of functional potentials is crucial for correlating device properties with their morphological/materials features, as well as for precisely tuning and optimizing their growth process. Electron Holographic Tomography (EHT) has been used in the past to reconstruct the total potential distribution in 3D but hitherto lacked a quantitative approach to separate potential variations due to chemical composition changes (mean inner potential - MIP) and space charges...
July 13, 2018: Nano Letters
Laura Balbás-Álvarez, Pablo Candelas-Fernández, Tamara Del Corral, Roy La Touche, Ibai López-de-Uralde-Villanueva
OBJECTIVE: The aim of this study is to assess whether adding manual therapy to motor control exercises protocol with inspiratory muscle training (IMT) (combined intervention) resulted in a greater effect than IMT alone in enhancing maximum inspiratory pressure (MIP) in the short term. METHODS: This was a single-blind, randomized, controlled trial. Fifty-one healthy moderate smokers were randomized into 2 groups: (1) IMT and (2) combined intervention. All participants received 8 individual sessions, 2 per week during a 4-week period...
July 9, 2018: Journal of Manipulative and Physiological Therapeutics
Hong Li, Qiang Liu, Ningfu Wang, Yizhou Xu, Lan Kang, Yaqi Ren, Gangjie Zhu
BACKGROUND: In a previous study, a low level of miR-126-3p in endothelial progenitor cells (EPCs) was linked to the outcome of ischemic cardiomyopathy (ICM) patients. However, it remains unclear whether transplantation with miR-126-3p-overexpressing EPCs (MO-EPCs) can improve the cardiac function of ICM animal models.Methods and Results:miR-126-3p overexpression by lentiviral vector significantly increased migration and tube-like structures of EPCs from ICM patients. MO-EPCs or non-modified EPCs (NM-EPCs) were transplanted into nude rats with ICM induced by coronary artery ligation...
July 10, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Xiuli Wang, Ying Xiong, Guocheng Liu, Hongyan Lin, Xiang Wang
In this work, four new NiII coordination polymers (CPs) based on a bi-methylene-bridged semi-rigid bis-pyridyl-bis-amide ligand and various polycarboxylates, namely, [Ni(4-bmbpd)(H2O)4]·(TPD) (1), [Ni2(4-bmbpd)2(1,3-BDC)2(H2O)4]·5H2O (2), [Ni2(4-bmbpd)2(MIP)2(H2O)2]·3H2O (3) and [Ni3(4-bmbpd)3(BTC)2(H2O)4]·4H2O (4) [4-bmbpd = N,N'-bis(4-methylenepyridin-4-yl)-1,4-benzenedicarboxamide, H2TPD = 2,5-thiophenedicarboxylic acid, 1,3-H2BDC = 1,3-benzenedicarboxylic acid, H2MIP = 5-methylisophthalic acid and 1,3,5-H3BTC = 1,3,5-benzenetricarboxylic acid] have been hydrothermally synthesized and structurally characterized by single-crystal X-ray diffraction analyses, thermal gravimetric (TG) analyses, IR spectroscopy and powder X-ray diffraction (PXRD)...
July 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Mascha Koenen, Stephan Culemann, Sabine Vettorazzi, Giorgio Caratti, Lucien Frappart, Wolfgang Baum, Gerhard Krönke, Ulrike Baschant, Jan P Tuckermann
BACKGROUND: Glucocorticoid (GC) therapy is frequently used to treat rheumatoid arthritis due to potent anti-inflammatory actions of GCs. Direct actions of GCs on immune cells were suggested to suppress inflammation. OBJECTIVES: Define the role of the glucocorticoid receptor (GR) in stromal cells for suppression of inflammatory arthritis. METHODS: Bone marrow chimeric mice lacking the GR in the hematopoietic or stromal compartment, respectively, and mice with impaired GR dimerisation (GRdim ) were analysed for their response to dexamethasone (DEX, 1 mg/kg) treatment in serum transfer-induced arthritis (STIA)...
July 11, 2018: Annals of the Rheumatic Diseases
Tim G A Calon, Martin L Johansson, Arthur J G de Bruijn, Herbert van den Berge, Mariet Wagenaar, Edwin Eichhorn, Miranda M L Janssen, Janny R Hof, Jan-Wouter Brunings, Manuela A Joore, Sofia Jonhede, Joost van Tongeren, Marcus Holmberg, Robert-Jan Stokroos
OBJECTIVE: To compare the surgical outcomes of the Minimally Invasive Ponto Surgery (MIPS) technique with those of the linear incision technique with soft-tissue preservation for bone-anchored hearing systems (BAHS). DESIGN: Sponsor-initiated multicenter, open, randomized, controlled clinical trial. SETTING: Maastricht University Medical Centre, Ziekenhuisgroep Twente and Medisch Centrum Leeuwarden, all situated in The Netherlands. PARTICIPANTS: Sixty-four adult patients eligible for unilateral BAHS surgery...
August 2018: Otology & Neurotology
Natasha A M Jackson, Angelina M Flores, Elizabeth D Eldon, Lisa S Klig
Inositol is a precursor for the phospholipid membrane component phosphatidylinositol (PI), involved in signal transduction pathways, endoplasmic reticulum stress, and osmoregulation. Alterations of inositol metabolism have been implicated in human reproductive issues, the therapeutic effects of drugs used to treat epilepsy and bipolar disorder, spinal cord defects, and diseases including diabetes and Alzheimer's. The sole known inositol synthetic enzyme is myo -inositol synthase (MIPS), and the homologue in D...
July 10, 2018: G3: Genes—Genomes—Genetics
Ting-Ting Chang, Liang-Yu Lin, Jaw-Wen Chen
Systemic inflammation might contribute to the impairment of neovasculogenesis and endothelial progenitor cell (EPC) function in clinical diabetes mellitus (DM). Macrophage inflammatory protein-1β (MIP-1β) is an inflammatory chemokine that may be up-regulated in clinical DM. Its role in diabetic vasculopathy was not clarified. This study aimed to investigate the role of MIP-1β in human EPCs and in neovasculogenesis in different diabetic animal models with hindlimb ischemia. EPCs chamber assay and in vitro tube formation assay were used to estimate the degree of EPC migration and tube formation abilities...
July 9, 2018: Angiogenesis
Artur Beke, Henriett Piko, Iren Haltrich, Veronika Karcagi, Janos Rigo, Maria Judit Molnar, György Fekete
BACKGROUND: Premature ovarian failure / primary ovarian insufficiency (POF/POI) associated with the mutations of the FMR1 (Fragile-X Mental Retardation 1) gene belongs to the group of the so-called trinucleotide expansion diseases. Our aim was to analyse the relationship between the paternally inherited premutation (PIP) and the maternally inherited premutation (MIP) by the examination of the family members of women with POF, carrying the premutation allele confirmed by molecular genetic testing...
July 9, 2018: BMC Medical Genetics
Benjamin Delwarde, Estelle Peronnet, Fabienne Venet, Elisabeth Cerrato, Boris Meunier, Julie Mouillaux, Alain Lepape, Alexandre Pachot, Thomas Rimmelé, Guillaume Monneret, Julien Textoris
OBJECTIVES: Septic shock is the primary cause of death in ICUs. A better comprehension of its pathophysiology, in particular, the immune alteration mechanisms, opened new therapeutic perspectives such as the recombinant interleukin-7. The use of biomarkers could improve the identification of eligible patients for this therapy. The soluble form of the interleukin-7 appears as a promising candidate in this regard since an association between its high plasmatic level and mortality in critically ill patients has been demonstrated...
July 6, 2018: Critical Care Medicine
Joshua M Liao, Judy A Shea, Arlene Weissman, Amol S Navathe
We surveyed a national sample of internal medicine physicians in March-May 2017 to explore their beliefs about the newly implemented Merit-based Incentive Payment System (MIPS). Respondents believed that their efforts in the four focus areas identified in the survey would ultimately improve the value of care. When informed that those areas represented the four MIPS domains, the majority remained positive about the likely impact on value. However, expectations varied by physicians' characteristics and sense of control over the desired outcomes, and many respondents believed that unintended consequences could occur...
July 2018: Health Affairs
F DI Giustino, P Vannucchi, R Pecci, A Mengucci, R Santimone, B Giannoni
In recent years, bone-anchored hearing implants (BAHIs) have found wider application in the treatment of conductive and mixed hearing loss. Several surgical techniques have been developed to reduce complications, enhance healing and improve audiological and aesthetic results. We report our experience on the use of three BAHI surgery techniques: Group 1, linear incision with thinning of the subcutaneous tissue; Group 2, linear incision without thinning of the subcutaneous tissue; Group 3, punch technique (Minimally Invasive Ponto Surgery, MIPS)...
June 2018: Acta Otorhinolaryngologica Italica
Yida Zhang, Huawei Cao, Qiangwei Huang, Xiaoyan Liu, Haixia Zhang
Transferrin (TrF) is a very important human body glycoprotein and a clinical biomarker which controls the body's iron ion channels and iron ion balance. Any change in TrF concentration and isoform also reflects the emergence of some diseases. In this work, we prepared magnetic molecularly imprinted nanoparticles (deep eutectic solvent-molecular imprinting polymers [DES-MIPs]) with a deep eutectic solvent (DES) as a functional monomer to separate TrF in human serum. The DES dosage for MIP, pH value, and time for adsorption have been optimized, and these materials show special adsorption properties for TrF...
July 7, 2018: Analytical and Bioanalytical Chemistry
Erdal Karavaş, Safiye Gürel, Aysu Kıyan, Sıddıka Halicioğlu, Emine Dağistan
OBJECTIVES: The aim of this study is to evaluate the effects of performing computed tomography (CT) urogram in the prone position in terms of diagnosis. METHODS: CT urograms of 208 patients imaged randomly in the prone and supine positions were included in this study. A total of 199 patients and 370 collecting systems were examined in total. Axial raw data and reconstructed coronal thin and thick MIP images with a slice thickness of 5 mm were evaluated by 2 independent radiologists blinded to the initial diagnosis...
July 6, 2018: Urologia Internationalis
Shasanka Sekhar Borkotoky, Gourhari Chakraborty, Vimal Katiyar
The current investigation addresses the thermal degradation and non-isothermal crystallization behaviour of the fabricated poly (lactic acid) foam (nPLA) and poly (lactic acid) (PLA)/cellulose nanocrystal (CNC) based foams at three different loadings of CNC (i.e. 1%, 2% and 3%) as PLA/CNC 1, PLA/CNC 2 and PLA/CNC 3 having highly porous, interconnected and microcellular morphology. The formation of various gaseous products at two different conversions (α = 0.3 and α = 0.7) are investigated by using thermogravimetric analyser hyphenated Fourier transmission infrared spectroscopy (TGA-FTIR) analysis in isothermal condition...
July 4, 2018: International Journal of Biological Macromolecules
Malgorzata E Kokoszka, Stefanie L Kall, Sehar Khosla, Jennifer E McGinnis, Arnon Lavie, Brian K Kay
Mixed-lineage kinase 3 (also known as MLK3 or MAP3K11) is a Ser/Thr protein kinase widely expressed in normal and cancerous tissues, including brain, lung, liver, heart, and skeletal muscle tissues. Its Src homology 3 (SH3) domain has been implicated in MLK3 autoinhibition and interactions with other proteins, including those from viruses. The MLK3 SH3 domain contains a six-amino-acid insert corresponding to the n-Src insert, suggesting that MLK3 may bind additional peptides. Affinity selection of a phage- displayed combinatorial peptide library for MLK3's SH3 domain yielded a 13-mer peptide, designated "MLK3 SH3-interacting peptide" (MIP)...
July 6, 2018: Journal of Biological Chemistry
Seung Mi Lee, Kyo Hoon Park, Eun Young Jung, Song Yi Kook, Hyunsoo Park, Se Jeong Jeon
OBJECTIVE: We aimed to assess the correlations among multiple cytokine concentrations in the maternal plasma, cervicovaginal fluid (CVF), and amniotic fluid (AF) compartments in women with preterm premature rupture of membranes (pPROM), and to develop a prediction model based on non-invasive measures, having better sensitivity and specificity for the identification of microbial invasion of amniotic cavity (MIAC). METHOD: This retrospective study included 75 consecutive women with pPROM (20+0-34+0 weeks), who underwent amniocentesis...
2018: PloS One
Yisong Qian, Chuqiao Chen, Leliang Ma, Ziwei Wang, Ling-Fang Wang, Li Zuo, Yaqin Yang, Xiang Huang, Meixiu Jiang, Xiaolei Wang, Huidong Shi, Mingui Fu, Ke-Yu Deng, Hong-Bo Xin
CD38 was first identified as a lymphocyte-specific antigen and then has been found to be widely expressed in a variety of cell types. The functions of CD38 are involved in numerous biological processes including immune responses. Here, we showed the downregulations of both TLR2 mRNA and protein in macrophages from CD38-/- mice and in CD38 knockdown RAW264.7 cells. Several NF- κ B-binding motifs in the promoter region of the TLR2 gene were identified by the bioinformatics analysis and were confirmed by the luciferase activity assay with the different truncated TLR2 promoters...
2018: Mediators of Inflammation
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