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https://www.readbyqxmd.com/read/27912964/a-systematic-review-and-meta-analysis-of-the-herbal-formula-buzhong-yiqi-tang-for-stable-chronic-obstructive-pulmonary-disease
#1
REVIEW
Yuanbin Chen, Johannah Linda Shergis, Lei Wu, Xuhua Yu, Qigang Zeng, Yinji Xu, Xinfeng Guo, Anthony Lin Zhang, Charlie Changli Xue, Lin Lin
OBJECTIVE: To systematically evaluate the efficacy and safety of Buzhong Yiqi Tang (BZYQT) for stable chronic obstructive pulmonary disease (COPD). METHODS: Three electronic English databases (PubMed, EMBASE and CENTRAL) and four Chinese databases (CBM, CNKI, CQVIP and WFMO) were searched from their inceptions until 30th June 2016. Participants were diagnosed with COPD according to the Chinese Medical Association's COPD diagnosis and treatment guidelines or Global Initiative for Chronic Obstructive Lung Disease (GOLD), and were in stable stage...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27910891/elevated-cerebral-spinal-fluid-biomarkers-in-children-with-mucopolysaccharidosis-i-h
#2
Gerald V Raymond, Marzia Pasquali, Lynda E Polgreen, Patricia I Dickson, Weston P Miller, Paul J Orchard, Troy C Lund
Mucopolysaccharidosis (MPS) type-IH is a lysosomal storage disease that results from mutations in the IDUA gene causing the accumulation of glycosaminoglycans (GAGs). Historically, children with the severe phenotype, MPS-IH (Hurler syndrome) develop progressive neurodegeneration with death in the first decade due to cardio-pulmonary complications. New data suggest that inflammation may play a role in MPS pathophysiology. To date there is almost no information on the pathophysiologic changes within the cerebral spinal fluid (CSF) of these patients...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910782/chemoprevention-of-colon-cancer-through-inhibition-of-angiogenesis-and-induction-of-apoptosis-by-nonsteroidal-anti-inflammatory-drugs
#3
Preety Ghanghas, Shelly Jain, Chandan Rana, Sankar Nath Sanyal
Cancer cells require nourishment for the growth of the primary tumor mass and spread of the metastatic colony. These needs are fulfilled by tumor-associated neovasculature known as angiogenesis, which also favors the transition from hyperplasia to neoplasia, that is, from a state of cellular multiplication to uncontrolled proliferation. Therefore, targeting angiogenesis is profitable as a mechanism to inhibit tumor growth. Furthermore, it is important to understand the cross-communication between vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in the neoplastic and proinflammatory milieu...
2016: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/27909456/serum-cytokine-levels-in-major-depressive-disorder-and-its-role-in-antidepressant-response
#4
Woojae Myung, Shinn-Won Lim, Hye In Woo, Jin Hong Park, Sanghong Shim, Soo-Youn Lee, Doh Kwan Kim
OBJECTIVE: Cytokines have been reported to have key roles in major depressive disorder (MDD). However, much less is known about cytokines in MDD and antidepressant treatment due to the diversity of cytokines and the heterogeneity of depression. We investigated the levels of cytokines in patients with MDD compared with healthy subjects and their associations with antidepressant response. METHODS: We investigated the changes of several cytokines (eotaxin, sCD40L, IL-8, MCP-1alpha, TNF-alpha, INF-gamma and MIP-1alpha) by Luminex assay in 66 patients with MDD and 22 healthy controls...
November 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27909226/unique-cytokine-and-chemokine-responses-to-exertional-heat-stroke-in-mice
#5
Michelle A King, Lisa R Leon, Deborah A Morse, Thomas L Clanton
In heat stroke, cytokines are believed to play important roles in multi-organ dysfunction and recovery of damaged tissue. The time course of the cytokine response is well defined in passive heat stroke (PHS), but little is known about exertional heat stroke (EHS). In this study we used a recently developed mouse EHS model to measure the responses of circulating cytokines/chemokines and cytokine gene expression in muscle. A very rapid increase in circulating IL-6 was observed at max core temperature (Tc,max) that peaked at 0...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27905815/medicare-program-merit-based-incentive-payment-system-mips-and-alternative-payment-model-apm-incentive-under-the-physician-fee-schedule-and-criteria-for-physician-focused-payment-models-final-rule-with-comment-period
#6
(no author information available yet)
The Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) repeals the Medicare sustainable growth rate (SGR) methodology for updates to the physician fee schedule (PFS) and replaces it with a new approach to payment called the Quality Payment Program that rewards the delivery of high-quality patient care through two avenues: Advanced Alternative Payment Models (Advanced APMs) and the Merit-based Incentive Payment System (MIPS) for eligible clinicians or groups under the PFS. This final rule with comment period establishes incentives for participation in certain alternative payment models (APMs) and includes the criteria for use by the Physician-Focused Payment Model Technical Advisory Committee (PTAC) in making comments and recommendations on physician-focused payment models (PFPMs)...
November 4, 2016: Federal Register
https://www.readbyqxmd.com/read/27903072/a-5-non-coding-exon-containing-engineered-intron-enhances-transgene-expression-from-recombinant-aav-vectors-in-vivo
#7
Jiamiao Lu, James A Williams, James Luke, Feijie Zhang, Kirk Chu, Mark A Kay
We previously developed a mini-intronic plasmid (MIP) expression system in which the essential bacterial elements for plasmid replication and selection are placed within an engineered intron contained within a universal 5'UTR non-coding exon. Like minicircle DNA plasmids (devoid of bacterial backbone sequences), MIP plasmids overcome transcriptional silencing of the transgene. However, in addition MIP plasmids increase transgene expression by 2 and often >10 times higher than minicircle vectors in vivo and in vitro...
November 30, 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27900349/symptomatic-bilateral-coronary-artery-fistula-to-pulmonary-artery-in-elderly-patient
#8
Francisco Pereira da Silva, Paulo Donato, Henrique Donato, Elisabete Jorge, Maria Joao Ferreira, Filipe Caseiro-Alves
We report the imaging findings of an uncommon coronary vascular termination anomaly, with fistula to the pulmonary artery. This 70 year old female patient presented unstable angina, showing a coronary artery fistula depicted in coronary angiogram from the left coronary to the pulmonary artery, with no significant atherosclerotic pathology. Due to development of ventricular tachycardia in stress echocardiogram examination, she was proposed for coronary fistula closure. Coronary CT was performed for procedure planning and allowed the identification of a second unsuspected fistula from the right coronary to the right pulmonary artery...
2016: European Journal of Radiology Open
https://www.readbyqxmd.com/read/27899332/artificial-neural-network-for-suppression-of-banding-artifacts-in-balanced-steady-state-free-precession-mri
#9
Ki Hwan Kim, Sung-Hong Park
The balanced steady-state free precession (bSSFP) MR sequence is frequently used in clinics, but is sensitive to off-resonance effects, which can cause banding artifacts. Often multiple bSSFP datasets are acquired at different phase cycling (PC) angles and then combined in a special way for banding artifact suppression. Many strategies of combining the datasets have been suggested for banding artifact suppression, but there are still limitations in their performance, especially when the number of phase-cycled bSSFP datasets is small...
November 26, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27899028/nano-liposome-based-target-toxicity-machine-an-alternative-complementary-approach-in-atopic-diseases
#10
Behzad Mansoori, Ali Mohammadi, Neda Shajari, Sadaf Davudian, Shima Salehi, Behzad Baradaran
Despite using lots of progression in hypersensitivity, it is not yet a cure. Current treatment for allergy focuses on two approaches, including treats only the symptoms of allergy by utilizing drugs and the other is desensitization therapy (immunotherapy), which involves administration of specific allergens. The main obstacle to hypersensitivity permanent treatment is the IgE producing subclass of B-lymphocytes which is the source of IgE- producing in hypersensitive patients. Removal of these lymphocytes causes noticeable reduction in the levels of IgE and allergic responses significantly...
November 29, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27898378/ag-n-doped-reduced-graphene-oxide-incorporated-with-molecularly-imprinted-polymer-an-advanced-electrochemical-sensing-platform-for-salbutamol-determination
#11
Junhua Li, Zhifeng Xu, Mengqin Liu, Peihong Deng, Siping Tang, Jianbo Jiang, Haibo Feng, Dong Qian, Lingzhi He
In this work, the metallic silver and non-metallic nitrogen co-doped reduced graphene oxide (Ag-N-RGO) was first synthesized by a simple and cost-effective strategy, and then a molecularly imprinted polymer (MIP) was formed in situ at the surface of the prepared composite via electropolymerization of o-phenylenediamine in the presence of salbutamol as the template molecule. The electrochemical characterizations demonstrate that the bifunctional graphene-based composite shows improved catalytic performance than that of pristine graphene doped with one-component or none...
November 10, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27895881/morphologic-evaluation-of-ductus-diverticulum-using-multi-detector-computed-tomography-comparison-with-traumatic-pseudoaneurysm-of-the-aortic-isthmus
#12
Jun Hyung Ann, Eun Young Kim, Yu Mi Jeong, Jeong Ho Kim, Hyung Sik Kim, Hye-Young Choi
OBJECTIVES: To evaluate morphologic variations at the aortic isthmus with particular attention to ductus diverticulum, a mimicker of traumatic pseudoaneurysm, and to describe differences using Computed Tomography (CT) images. PATIENTS AND METHODS: From December 2013 to December 2014, patients who underwent a chest CT examination after blunt trauma at our emergency department were included. Aortic isthmus morphologies were evaluated using multiplanar reconstruction (MPR) and maximum intensity projection (MIP) images as follows...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27895491/comparison-of-internal-target-volumes-defined-on-3-dimensional-4-dimensonal-and-cone-beam-ct-images-of-non-small-cell-lung-cancer
#13
Fengxiang Li, Jianbin Li, Zhifang Ma, Yingjie Zhang, Jun Xing, Huanpeng Qi, Dongping Shang
PURPOSE: The purpose of this study was to compare the positional and volumetric differences of internal target volumes defined on three-dimensional computed tomography (3DCT), four-dimensional CT (4DCT), and cone-beam CT (CBCT) images of non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: Thirty-one patients with NSCLC sequentially underwent 3DCT and 4DCT simulation scans of the thorax during free breathing. The first CBCT was performed and registered to the planning CT using the bony anatomy registration during radiotherapy...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27894918/laser-speckle-contrast-imaging-and-oxygen-to-see-for-assessing-microcirculatory-liver-blood-flow-changes-following-different-volumes-of-hepatectomy
#14
Chong Hui Li, Xin Lan Ge, Ke Pan, Peng Fei Wang, Yi Nan Su, Ai Qun Zhang
OBJECTIVE: Portal hyperperfusion after extended hepatectomy or small-for-size liver transplantation may induce organ dysfunction and failure. This study was designed to monitor and characterize the hepatic microcirculatory perfusion following different volumes of hepatectomy in rats by using laser speckle contrast image (LSCI) and Oxygen to See (O2C), a spectrometric device. METHODS: The microcirculatory liver blood flow of the rats that underwent 68%, 85% and 90% hepatectomy (68PH, 85PH and 90PH) was monitored with LSCI and O2C before and following the hepatectomy...
November 25, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27894396/ellagic-acid-ameliorates-cuprizone-induced-acute-cns-inflammation-via-restriction-of-microgliosis-and-down-regulation-of-ccl2-and-ccl3-pro-inflammatory-chemokines
#15
N Sanadgol, F Golab, A Mostafaie, M Mehdizadeh, M Abdollahi, M Sharifzadeh, H Ravan
Ellagic acid (EA) is a natural phenol antioxidant with various therapeutic activities. However, the efficacy of EA has not been examined in neuro-inflammatory conditions. Microglia making the innate immune system of the central nervous system (CNS) and are imperative cellular mediators of neuro-inflammatory processes. In this study, neuro-protective effects of EA on cuprizone (Cup)-induced acute CNS inflammation evaluated. C57BL/6J mice were fed with chow containing 0.2 % Cup for 3 weeks to induce acute neuro-inflammation predominantly in the corpus callosum (CC)...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27890683/the-effect-of-obesity-on-perioperative-outcomes-for-open-and-minimally-invasive-prostatectomy
#16
Scott C Johnson, Vignesh T Packiam, Shay Golan, Andrew J Cohen, Charles U Nottingham, Norm D Smith
OBJECTIVES: To compare the impact of obesity on perioperative outcomes between open radical prostatectomy (ORP) and minimally invasive prostatectomy (MIP). METHODS: Using the National Surgical Quality Improvement Program (NSQIP) public use files for 2008-2013, we identified patients undergoing prostatectomy using current procedural terminology codes. Those without BMI or comorbidity information were excluded. BMI was treated as a categorical variable according to the World Health Organization classification...
November 24, 2016: Urology
https://www.readbyqxmd.com/read/27890459/relationship-of-systemic-cytokine-concentrations-to-cognitive-function-over-two-years-in-women-with-early-stage-breast-cancer
#17
Debra E Lyon, Ronald Cohen, Huaihou Chen, Debra L Kelly, Nancy L McCain, Angela Starkweather, Hyochol Ahn, Jamie Sturgill, Colleen K Jackson-Cook
: Cancer and its treatment are frequently associated with cancer-related cognitive impairment (CRCI). While CRCI has been associated with linked to chemotherapy, there is increasing evidence that the condition may start prior to treatment and for some, remain unresolved after active treatment and into survivorship. Although the pathophysiology of the condition is complex, alterations in systemic cytokines, signaling molecules activated in response to infection or injury that trigger inflammation, are a possible mechanism linked to cognitive dysfunction in breast cancer and other conditions...
November 13, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27888496/methanol-gas-sensing-properties-of-swcnt-mip-composites
#18
Jin Zhang, Qin Zhu, Yumin Zhang, Zhongqi Zhu, Qingju Liu
The single-walled carbon nanotube (SWCNT)-molecularly imprinted powder (MIP) composites in this paper were prepared by mixing SWCNTs with MIPs. The structure and micrograph of the as-prepared SWCNTs-MIPs samples were characterized by XRD and TEM. The gas-sensing properties were tested through indirect-heating sensors based on SWCNT-MIP composites fabricating on an alumina tube with Au electrodes and Pt wires. The results showed that the structure of SWCNTs-MIPs is of orthogonal perovskite and the average particle size of the SWCNTs-MIPs was in the range of 10-30 nm...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27886767/preparation-and-characterization-of-magnetic-molecularly-imprinted-polymers-for-the-extraction-of-hexamethylenetetramine-in-milk-samples
#19
Xing Xu, Emmanuel Duhoranimana, Xiaoming Zhang
Magnetic molecularly imprinted polymers (M-MIPs) were synthesized as the sorbents for extracting hexamethylenetetramine (HMT) from milk samples. Molecular simulations were used to calculate the interaction energies of the template monomers. The physical properties of M-MIPs were characterized. The adsorption isotherms and kinetics were investigated. Gas chromatography coupled with tandem mass spectrometry (GC-MS/MS) was applied to determine the amount of HMT residue in milk samples. In the optimized method, a linear calibration curve was obtained using a matrix-matched standard in the range of 1...
January 15, 2017: Talanta
https://www.readbyqxmd.com/read/27886070/molecularly-imprinted-filtering-adsorbents-for-odor-sensing
#20
Sho Shinohara, You Chiyomaru, Fumihiro Sassa, Chuanjun Liu, Kenshi Hayashi
Versatile odor sensors that can discriminate among huge numbers of environmental odorants are desired in many fields, including robotics, environmental monitoring, and food production. However, odor sensors comparable to an animal's nose have not yet been developed. An animal's olfactory system recognizes odor clusters with specific molecular properties and uses this combinatorial information in odor discrimination. This suggests that measurement and clustering of odor molecular properties (e.g., polarity, size) using an artificial sensor is a promising approach to odor sensing...
November 23, 2016: Sensors
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