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https://www.readbyqxmd.com/read/29144579/tailor-made-molecularly-imprinted-polymer-for-selective-recognition-of-the-urinary-tumor-marker-pseudouridine
#1
Aleksandra Krstulja, Stefania Lettieri, Andrew J Hall, Vincent Roy, Patrick Favetta, Luigi A Agrofoglio
Pseudouridine (Ψ) is an important urinary cancer biomarker, especially in human colorectal cancer (CRC). Disclosed herein is the first Ψ molecularly imprinted polymer (Ψ-MIP) material obtained from tailor-engineered functional monomers. The resulting MIP imprint exhibits a remarkable imprinting factor greater than 70. It is successfully used for the selective recognition of Ψ in spiked human urine. This selective functionalized material opens the route to the development of inexpensive disposable chemosensors for noninvasive CRC diagnosis and prognosis...
November 16, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29142471/dachaihu-decoction-ameliorates-pancreatic-fibrosis-by-inhibiting-macrophage-infiltration-in-chronic-pancreatitis
#2
Li-Fang Duan, Xiao-Fan Xu, Lin-Jia Zhu, Fang Liu, Xiao-Qin Zhang, Nan Wu, Jian-Wei Fan, Jia-Qi Xin, Hong Zhang
AIM: To explore the role of macrophages in chronic pancreatitis (CP) and the effect of Dachaihu decoction (DCHD) on pancreatic fibrosis in mice. METHODS: KunMing mice were randomly divided into a control group, CP group, and DCHD group. In the CP and DCHD groups, mice were intraperitoneally injected with 20% L-arginine (3 g/kg twice 1 d/wk for 6 wk). Mice in the DCHD group were administered DCHD intragastrically at a dose of 14 g/kg/d 1 wk after CP induction. At 2 wk, 4 wk and 6 wk post-modeling, the morphology of the pancreas was observed using hematoxylin and eosin, and Masson staining...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29141920/parathyroid-hormone-related-protein-modulates-mice-mesangial-cells-inflammation-and-blunts-apoptosis-by-enhancing-cox-2-expression
#3
Mazène Hochane, Denis Raison, Catherine Coquard, Claire Béraud, Audrey Bethry, Sabrina Danilin, Thierry Massfelder, Mariette Barthelmebs
Mesangial cell (MC) injury is a prominent feature of glomerulonephritis. Activated MC secretes inflammatory mediators which induce cell apoptosis. Parathyroid hormone-related peptide (PTHrP) is a locally active cytokine that enhances cell survival and is upregulated by pro-inflammatory factors in many cell types. The aim of this study was to analyze the regulation of PTHrP expression by inflammatory cytokines, and to evaluate whether PTHrP itself acts as a pro-inflammatory and/or survival factor on male murine MC in primary culture...
November 15, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29137744/luminescence-electrochemical-and-photocatalytic-properties-of-sub-micron-nickel-ii-and-cobalt-ii-coordination-polymers-synthesized-by-sonochemical-process
#4
Jun Xuan Li, Yu Feng Li, Li Wei Liu, Guang Hua Cui
Submicron structures of Ni(II)/Co(II)-based coordination polymers (CPs) [Ni(L1)(mip)·H2O]n (1) and {[Co(L2)(mip)]·0·.5H2O}n(2) (L1=1,6-bis(5,6-dimethylbenzimidazole)hexane, L2=1,6-bis(benzimidazole)hexane, H2mip=5-methylisophthalic acid) were obtained by ultrasonic irradiation and structurally characterized by elemental analysis, powder X-ray diffraction and scanning electron microscopy. Structural analysis show that two CPs feature uninodal 3-connected 2D hcb layer, whilst CP 2 is further extended into a 3D complicated supramolecular network by C14-H14⋯O2 hydrogen bonds...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137709/simultaneous-detection-of-folic-acid-and-methotrexate-by-an-optical-sensor-based-on-molecularly-imprinted-polymers-on-dual-color-cdte-quantum-dots
#5
Ali A Ensafi, Parisa Nasr-Esfahani, B Rezaei
In this work, molecularly imprinted polymers (MIPs) were used on the surface of cadmium telluride quantum dots (CdTe QDs) for the simultaneous determination of folic acid (FA) and methotrexate (MTX). For this purpose, two different sizes of CdTe QDs with emission peaks in the yellow (QDY) and orange (QDO) spectral regions were initially synthesized and capped with MIPs. FA and MTX were used as templates for the synthesis of the two composites and designated as QDY-MIPs and QDO-MIPs, respectively. Fourier transform infrared spectroscopy, transmission electron microscopy, and fluorescence spectroscopy were employed to characterize the composites...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29137362/an-optimized-hmgb1-expressed-by-recombinant-rabies-virus-enhances-immunogenicity-through-activation-of-dendritic-cells-in-mice
#6
Zhao Wang, Qian Liang, Yajing Zhang, Jie Yang, Mingming Li, Kunlun Wang, Min Cui, Huanchun Chen, Zhen F Fu, Ling Zhao, Ming Zhou
Rabies remains an important public health threat, killing approximately 59,000 people worldwide annually, most of which are from the developing countries of Africa and Asia where dog rabies are endemic. Therefore, developing an affordable and efficacious vaccine for dog-mediated rabies control is needful in these countries. Our previous studies indicated that over-expression of granulocyte-macrophage colony stimulating factor (GM-CSF) or macrophage inflammatory protein-1 (MIP-1α or CCL3) by recombinant rabies virus (rRABV) could enhance the immunogenicity by activating dendritic cells (DCs)...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136919/flow-batch-analysis-of-clenbuterol-based-on-analyte-extraction-on-molecularly-imprinted-polymers-coupled-to-an-in-system-chromogenic-reaction-application-to-human-urine-and-milk-substitute-samples
#7
Natalia González, Marcos Grünhut, Ivana Šrámková, Adriana G Lista, Burkhard Horstkotte, Petr Solich, Hana Sklenářová, Carolina C Acebal
A fully automated spectrophotometric method based on flow-batch analysis has been developed for the determination of clenbuterol including an on-line solid phase extraction using a molecularly imprinted polymer (MIP) as the sorbent. The molecularly imprinted solid phase extraction (MISPE) procedure allowed analyte extraction from complex matrices at low concentration levels and with high selectivity towards the analyte. The MISPE procedure was performed using a commercial MIP cartridge that was introduced into a guard column holder and integrated in the analyzer system...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136855/molecularly-imprinted-polymer-mip-membrane-assisted-direct-spray-ionization-mass-spectrometry-for-agrochemicals-screening-in-foodstuffs
#8
Igor Pereira, Marcella Ferreira Rodrigues, Andréa Rodrigues Chaves, Boniek Gontijo Vaz
Paper spray ionization (PSI) has some limitations such as low sensitivity and ionization suppression when complex samples are analyzed. The use of sample preparation devices directly coupled to MS can avoid these restrictions. Molecularly imprinted polymers (MIPs) are materials widely used as adsorbent in sample preparation methods such as solid-phase extraction and solid-phase microextraction, and they can provide specifics cavities with affinity to a target molecule. Here, we introduce a new MIP membrane spray ionization method combining MIP and PSI...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29133633/altered-tear-inflammatory-profile-in-indian-keratoconus-patients-the-2015-col-rangachari-award-paper
#9
Rohit Shetty, Rashmi Deshmukh, Arkasubhra Ghosh, Swaminathan Sethu, Chaitra Jayadev
PURPOSE: Conventionally, keratoconus (KC) has been considered a noninflammatory corneal ectatic disorder. Recent evidence suggests a possible role of inflammation in the pathogenesis of KC. Hence, we analyzed the levels of inflammatory factors in the tear fluid of Indian KC patients. METHODS: Tear fluid samples were collected from age- and sex-matched healthy controls and KC patients (with different grades). The levels of the inflammatory factors in tears were analyzed using cytometric bead array (Human Soluble Protein Flex Set System, BD Biosciences) for levels of interleukin-1α (IL-1α), IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-12p70, IL-23p40, IL-13, IL-17A, IL-17F, IL-21, interferon-α (IFNα), IFNγ, tumor necrosis factor-α, CCL2/monocyte chemotactic protein-1, CCL4/macrophage inflammatory protein-1β (MIP-1β), MIP-1α, CCL5/RANTES, CXCL10/IP10, ICAM1, CD62E, vascular endothelial growth factor and transforming growth factor β...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29127244/imaging-of-the-thyroid-and-parathyroid-using-a-cardiac-cadmium-zinc-telluride-camera-phantom-studies
#10
Yosuke Miyazaki, Yasuhiro Kato, Akira Imoto, Kazuki Fukuchi
Purpose: Cadmium zinc telluride (CZT) detectors have recently been introduced to the field of clinical nuclear cardiology. However, the feasibility of using them for organs other than the heart remains unclear. The aim of this study was to evaluate the potential of a cardiac CZT camera to acquire thyroid and parathyroid images. We used custom-made phantoms and the currently available standard protocols for CZT, instead of a sodium-iodine scintillation (NaI) camera. Materials and Methods: Thyroid phantoms with or without parathyroid adenomas were made from agar using radiopharmaceuticals ((99m)Tc or (123)I) and imaged using CZT and NaI cameras...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29127109/incb040093-is-a-novel-pi3k%C3%AE-inhibitor-for-the-treatment-of-b-cell-lymphoid-malignancies
#11
Niu Shin, Yun-Long Li, Song Mei, Kathy He Wang, Leslie Hall, Kamna Katiyar, Qian Wang, Gengjie Yang, Beth Rumberger, Lynn Leffet, Xin He, Mark Rupar, Kevin Bowman, Margaret Favata, Jun Li, Mike Liu, Yanlong Li, Maryanne Covington, Holly Koblish, Maxim Soloviev, Dana Shuey, Timothy Burn, Sharon Diamond, Jordan Fridman, Andrew Combs, Wenqing Yao, Swamy Yeleswaram, Gregory Hollis, Kris Vaddi, Reid Huber, Robert Newton, Peggy Scherle
PI3Kδ is a critical signaling molecule in B cells and is considered a target for development of therapies against various B cell malignancies. INCB040093 is a novel PI3Kδ small molecule inhibitor and has demonstrated promising efficacy in patients with Hodgkin's lymphoma in clinical studies. Here, we disclose the chemical structure and the preclinical activity of the compound. In biochemical assays, INCB040093 potently inhibits the PI3Kδ kinase, with 74 to >900-fold selectivity against other PI3K family members...
November 10, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29126887/combined-administration-of-resolvin-e1-and-lipoxin-a4-resolves-inflammation-in-a-murine-model-of-alzheimer-s-disease
#12
Alpdogan Kantarci, Nurgul Aytan, Iro Palaska, Danielle Stephens, Leah Crabtree, Claudia Benincasa, Bruce G Jenkins, Isabel Carreras, Alpaslan Dedeoglu
Dysfunction in the resolution of inflammation may play a key role in Alzheimer's disease (AD). In this study, we found that the levels of specialized pro-resolving lipid mediators (SPMs) in the hippocampus of 5xFAD mice are significantly lower than in non-transgenic littermates. We, therefore, tested the hypothesis that treatment with resolvin E1 (RvE1) and lipoxin A4 (LXA4) alone or in combination will reverse the neuroinflammatory process and decrease Aβ pathology. 5xFAD mice were treated intraperitoneally starting at 1month of age with RvE1 or LXA4 alone or in combination at a dose of 1...
November 7, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29126084/a-simple-and-highly-selective-molecular-imprinting-polymer-based-methodology-for-propylparaben-monitoring-in-personal-care-products-and-industrial-waste-waters
#13
Ana Vicario, Leslie Aragón, Chien C Wang, Franco Bertolino, María R Gomez
In this work, a novel molecularly imprinted polymer (MIP) proposed as solid phase extraction sorbent was developed for the determination of propylparaben (PP) in diverse cosmetic samples. The use of parabens (PAs) is authorized by regulatory agencies as microbiological preservative; however, recently several studies claim that large-scale use of these preservatives can be a potential health risk and harmful to the environment. Diverse factors that influence on polymer synthesis were studied, including template, functional monomer, porogen and crosslinker used...
November 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29125113/ultrasound-guided-selective-cervical-nerve-root-block-plus-superficial-cervical-plexus-block-for-minimally-invasive-parathyroidectomy
#14
Xu Li, Min-Na Li, Xu-Lei Cui, Shu-Ai Tang, Ya Hu, Quan Liao, Yu-Guang Huang
Objective To explore the efficacy and safety of ultrasound-guided cervical root block (CRB) in patients undergoing minimally invasive parathyroidectomy (MIP).Methods We enrolled 35 patients with hyperparathyroidism undergoing MIP in Peking Union Medical College Hospital.C4-7 nerve roots were identified in ultrasound imaging by the shape of the transverse process.A 50 mm insulated needle was gently introduced by an in-plane approach toward the posterior edge of the nerve root located at the inside of the posterior tubercle...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29124630/effectiveness-of-inspiratory-muscle-training-on-sleep-and-functional-capacity-to-exercise-in-obstructive-sleep-apnea-a-randomized-controlled-trial
#15
Adília Karoline Ferreira Souza, Armèle Dornelas de Andrade, Ana Irene Carlos de Medeiros, Maria Inês Remígio de Aguiar, Taciano Dias de Souza Rocha, Rodrigo Pinto Pedrosa, Anna Myrna Jaguaribe de Lima
PURPOSE: The aim of this study was to evaluate the effectiveness of inspiratory muscle training (IMT) on sleep and functional capacity to exercise in subjects with obstructive sleep apnea (OSA). METHODS: This is a controlled, randomized, double-blind study conducted in 16 OSA patients divided into two groups: training (IMT: n = 8) and placebo-IMT (P-IMT: n = 8). IMT was conducted during 12 weeks with a moderate load (50-60% of maximal inspiratory pressure-MIP), while P-IMT used a load < 20% of MPI...
November 9, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29124305/dummy-surface-molecularly-imprinted-polymers-as-a-sorbent-of-micro-solid-phase-extraction-combined-with-dispersive-liquid-liquid-microextraction-for-determination-of-five-2-phenylpropionic-acid-nsaids-in-aquatic-environmental-samples
#16
Ping Guo, Xucan Yuan, Jingjing Zhang, Binjie Wang, Xiaoyang Sun, Xiaohui Chen, Longshan Zhao
A highly binding dummy template surface of molecularly imprinted polymers (MWNTs-MIPs) was synthesized on multi-walled carbon nanotubes surface using 2-phenylpropionic acid as dummy template, 4-vinylpyridine as the functional monomer, ethylene glycol dimethacrylate as the cross-linker, and DMF as porogen by precipitation polymerization method. MIPs were characterized by FT-IR spectroscopy, scanning electron microscope, thermo-gravimetric analysis, and nitrogen adsorption-desorption experiment. Adsorption and selectivity experiments of MIPs and non-imprinted polymers (NIPs) verified that the MIPs had a good selectivity and adsorption properties for five 2-phenylpropionic acid nonsteroidal anti-inflammatory drugs (NSAIDs)...
November 9, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29122013/suppression-of-methylmercury-induced-mip-2-expression-by-n-acetyl-l-cysteine-in-murine-raw264-7-macrophage-cell-line
#17
Juliet David, Athira Nandakumar, Muflihatul Muniroh, Suminori Akiba, Megumi Yamamoto, Chihaya Koriyama
BACKGROUND: The aim of this study is to examine the inflammatory-cytokine expressions in the presence of non-cytotoxic dose of methylmercury (MeHg) in murine macrophages, which is suspected to play an important role in brain damage caused by MeHg exposure. We focused on murine macrophage inflammatory protein-2 (MIP-2), keratinocyte chemoattractant (KC), and monocyte chemoattractant protein-5 (MCP-5). MIP-2 and KC are murine functional homologues of human IL-8 and MCP-5 for human MCP-1...
November 9, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29121396/role-of-gut-derived-endotoxin-on-type-i-collagen-production-in-the-rat-pancreas-after-chronic-alcohol-exposure
#18
Hongyan Li, Ming Xiu, Shuhua Wang, David R Brigstock, Li Sun, Limei Qu, Runping Gao
BACKGROUND: Pancreatic fibrosis is a key pathological feature of alcoholic chronic pancreatitis (ACP). Bacterial endotoxin lipopolysaccharide (LPS) is considered as an important cofactor in the fibrogenesis of ACP. However, there are limitations in the use of exogenous LPS for evaluating the role of endotoxin in ACP pathogenesis. In this study we determined the relationship between the concentration of LPS in the portal vein and pancreatic type I collagen (Col1) content in chronic alcohol-fed rats...
November 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29121128/acronymic-despair-macra-mips-and-me
#19
Mark D Kaufmann, Daniel M Siegel
No abstract text is available yet for this article.
September 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29120471/rational-design-of-a-molecularly-imprinted-polymer-for-dinotefuran-theoretical-and-experimental-studies-aimed-at-the-development-of-an-efficient-adsorbent-for-microextraction-by-packed-sorbent
#20
Camilla Fonseca Silva, Keyller Bastos Borges, Clebio Soares do Nascimento
In this work, we studied theoretically the formation process of a molecularly imprinted polymer (MIP) for dinotefuran (DNF), testing distinct functional monomers (FM) in various solvents through density functional theory calculations. The results revealed that the best conditions for MIP synthesis were established with methacrylic acid (MAA) as FM in a 1 : 4 stoichiometry and with chloroform as the solvent. This protocol showed the most favourable stabilization energies for the pre-polymerization complexes...
November 9, 2017: Analyst
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