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An Hu, Hai-Bin Liu, Robert Mlynski, Stefan Plontke, Jing-Fei Zhang, Wei-Jun Dai, Jun-Li Duan, Jing-Ping Fan, Hong-Liang Zheng, Wei-Hua Xu, Xiao-Ping Chen, Jing-Juan Huang
Background: Postoperative pain has well defined and is perceived by patients as one of the most obnoxious aspects of surgical pain. The aim of this study was to determine whether the combination of Therapeutic ultrasound (TUS) and Curcumin (CUR) resulted in an enhancement of their pain relieving activities in a rat model of postoperative pain. Methods: We explored the effect of these treatment and their interaction with signal transduction pathways involved in inflammatory. In this study, TUS and CUR alone or in combination were administered prior to or simultaneously with or after the incisional surgery...
2018: American Journal of Translational Research
Chandra Prakash Chaturvedi, Naresh Kumar Tripathy, Ekta Minocha, Akhilesh Sharma, Khaliqur Rahman, Soniya Nityanand
We have investigated the expression of RNA transcripts of hematopoiesis regulatory molecules, viz., macrophage inflammatory protein (MIP)-1 α , tumor necrosis factor (TNF)- α , granulocyte colony-stimulating factor (G-CSF), stromal cell-derived factor (SDF)-1 α , stem cell factor (SCF), and transforming growth factor (TGF)- β in lipopolysaccharide-induced bone marrow mesenchymal stem cells (BM-MSCs) and levels of their soluble forms in the culture supernatants of BM-MSCs and BM plasma of patients with acquired aplastic anemia (AA) ( n = 29) and controls ( n = 29)...
2018: Stem Cells International
Zhe Yuan, Jijun Xu, Yongqiang Wang
Projecting future changes in extreme flood is critical for risk management. This paper presented an analysis of the implications of the Fifth Coupled Model Intercomparison Project Phase (CMIP5) climate models on the future flood in the Jinsha River Basin (JRB) in Southwest China, using the Xinanjiang (XAJ) hydrologic model. The bias-corrected and resampled results of the multimodel dataset came from the Inter-Sectoral Impact Model Intercomparison Project (ISI-MIP). Relatively optimal general circulation models (GCMs) were selected with probability density functions (PDFs)-based assessment...
November 8, 2018: International Journal of Environmental Research and Public Health
Bowen Zhao, Shaolong Feng, Yaxi Hu, Shuo Wang, Xiaonan Lu
Rapid and reliable determination of atrazine, a common chemical contaminant, in agri-foods is highly necessary. We reported a novel dual-chemosensor coupling, a separation [molecularly imprinted polymers (MIPs)], an instrumental-free detection [gold nanoparticles (AuNPs)-based colorimetric assay] and an instrument-based quantification [surface enhanced Raman spectroscopy (SERS)] method for high-throughput and sensitive determination of atrazine in apple juice. Used as the selective sorbent for the solid phase extraction, MIPs effectively extracted atrazine from apple juice with high recoveries (∼93%)...
March 15, 2019: Food Chemistry
Karima Sahmoudi, Hassan Abbassi, Nada Bouklata, Mohamed Nouredine El Alami, Abderrahmane Sadak, Christopher Burant, W Henry Boom, Rajae El Aouad, David H Canaday, Fouad Seghrouchni
BACKGROUND: Lymph node tuberculosis (LNTB) is the most frequent extrapulmonary form of tuberculosis (TB). Studies of human tuberculosis at sites of disease are limited. LNTB provides a unique opportunity to compare local in situ and peripheral blood immune response in active Mycobacterium tuberculosis (Mtb) disease. The present study analysed T regulatory cells (Treg) frequency and activation along with CD4+ T cell function in lymph nodes from LNTB patients. RESULTS: Lymph node mononuclear cells (LNMC) were compared to autologous peripheral blood mononuclear cells (PBMC)...
November 8, 2018: BMC Immunology
Andrea Bryndum-Buchholz, Derek P Tittensor, Julia L Blanchard, William W L Cheung, Marta Coll, Eric D Galbraith, Simon Jennings, Olivier Maury, Heike K Lotze
Climate change effects on marine ecosystems include impacts on primary production, ocean temperature, species distributions and abundance at local to global scales. These changes will significantly alter marine ecosystem structure and function with associated socio-economic impacts on ecosystem services, marine fisheries, and fishery-dependent societies. Yet how these changes may play out among ocean basins over the 21st century remains unclear, with most projections coming from single ecosystem models that do not adequately capture the range of model uncertainty...
November 8, 2018: Global Change Biology
Makoto Suzuki, Satoru Morita, Yasuhiro Goto, Hitoshi Tadenuma, Yu Nishina, Masami Yoneyama, Isao Tanaka, Shuji Sakai
OBJECTIVE: To compare single-shot turbo spin-echo (TSE) diffusion-weighted whole-body imaging with background suppression (DWIBS) and echo-planar imaging (EPI) DWIBS to determine the feasibility of direct-coronal TSE-DWIBS. METHODS: All measurements were performed using a 3.0 T MRI scanner. In the phantom study, we compared the contrast ratios (CRs) of tumor-mimicking phantom (tumor) to muscle-mimicking phantom (muscle) and water to muscle and the signal-to-noise ratio (SNR) between TSE-DWIBS and EPI-DWIBS...
November 8, 2018: British Journal of Radiology
Vineet Joag, Onyango Obila, Pawel Gajer, Milcah Carol Scott, Sara Dizzell, Michael Humphrys, Kamnoosh Shahabi, Sanja Huibner, Brett Shannon, Wangari Tharao, Marianne Mureithi, Julius Oyugi, Joshua Kimani, Charu Kaushic, Jacques Ravel, Omu Anzala, Rupert Kaul
Background: Genital immunology is a key determinant of human immunodeficiency virus (HIV) susceptibility. Both factors are modulated by bacterial vaginosis (BV) and, to some extent, by Lactobacillus iners, the genital Lactobacillus spp. that predominates in African, Caribbean, and other Black (ACB) women. We conducted a clinical trial to assess the impact of oral metronidazole treatment on the genital immune parameters of HIV acquisition risks in Kenyan women with BV. Methods: The primary endpoint was ex vivo cervical CD4+ T-cell HIV susceptibility after 1 month; secondary endpoints included genital cytokine/chemokine levels, cervical immune cell populations, and the composition of the cervico-vaginal microbiota by 16S ribosomal RNA gene amplicon sequencing...
September 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Maria Teresa Gonzalez-Garza, Hector Ramon Martinez, Delia E Cruz-Vega, Martin Hernandez-Torre, Jorge E Moreno-Cuevas
Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder that selectively attacks motor neurons in the brain and spinal cord. Despite important advances in the knowledge of the etiology and progression of the disease, there are still no solid grounds in which a clinician could make an early objective and reliable diagnosis from which patients could benefit. Diagnosis is difficult and basically made by clinical rating scales (ALSRs and El Escorial). The possible finding of biomarkers to aid in the early diagnosis and rate of disease progression could serve for future innovative therapeutic approaches...
2018: Disease Markers
Jimena Salido, María Julia Ruiz, César Trifone, María Inés Figueroa, María Paula Caruso, María Magdalena Gherardi, Omar Sued, Horacio Salomón, Natalia Laufer, Yanina Ghiglione, Gabriela Turk
Since anti-HIV treatment cannot cure the infection, many strategies have been proposed to eradicate the viral reservoir, which still remains as a major challenge. The success of some of these strategies will rely on the ability of HIV-specific CD8+ T-cells (CD8TC) to clear reactivated infected cells. Here, we aimed to investigate the phenotype and function of in vitro expanded CD8TC obtained from HIV+ subjects on combination antiretroviral therapy (cART), either initiated earlier (median = 3 months postinfection, ET: Early treatment) or later (median = 20 months postinfection, DT: Delayed treatment) after infection...
2018: Frontiers in Immunology
Virginia Santiago, Katayoun Rezvani, Takuya Sekine, Justin Stebbing, Peter Kelleher, Darius Armstrong-James
Pulmonary aspergillosis is an opportunistic fungal infection affecting immunocompromised individuals. Increasing understanding of natural killer (NK) cell immunobiology has aroused considerable interest around the role of NK cells in pulmonary aspergillosis in the immunocompromised host. Murine studies indicate that NK cells play a critical role in pulmonary clearance of A. fumigatus . We show that the in vitro interaction between NK cells and A. fumigatus induces partial activation of NK cell immune response, characterised by low-level production of IFN-γ, TNF-α, MIP-1α, MIP-1β, and RANTES, polarisation of lytic granules and release of fungal DNA...
2018: Frontiers in Immunology
Gregory S Olson, Sarah W Moore, James M Richter, John J Garber, Brittany A Bowman, Crystal A Rawlings, Meaghan Flagg, Björn Corleis, Douglas S Kwon
γδ T cells predominate in the intestinal mucosa and help maintain gut homeostasis and mucosal immunity. Although HIV infection significantly alters these cells, what drives these perturbations is unclear. Growing evidence suggests that impaired intestinal immune function in HIV leads to chronic immune activation and disease progression. This occurs even in HIV controllers - individuals with undetectable HIV viremia without antiretroviral therapy (ART). We show that Vδ1+ cells, a subset of γδ T cells described as being important in intestinal barrier function, increase in frequency in HIV-infected individuals, including HIV controllers...
November 7, 2018: Scientific Reports
Natalia Manousi, George A Zachariadis, Eleni A Deliyanni, Victoria F Samanidou
Food samples such as milk, beverages, meat and chicken products, fish, etc. are complex and demanding matrices. Various novel materials such as molecular imprinted polymers (MIPs), carbon-based nanomaterials carbon nanotubes, graphene oxide and metal-organic frameworks (MOFs) have been recently introduced in sample preparation to improve clean up as well as to achieve better recoveries, all complying with green analytical chemistry demands. Metal-organic frameworks are hybrid organic inorganic materials, which have been used for gas storage, separation, catalysis and drug delivery...
November 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Camila Camponogara, Rosana Casoti, Indiara Brusco, Mariana Piana, Aline A Boligon, Daniela Almeida Cabrini, Gabriela Trevisan, Juliano Ferreira, Cássia Regina Silva, Sara Marchesan Oliveira
ETHNOPHARMACOLOGICAL RELEVANCE: Tabernaemontana catharinensis, popularly known as snakeskin, is used in traditional medicine to treat skin inflammatory disorders. To confirm the topical anti-inflammatory effect of T. catharinensis leaves, we evaluated the therapeutic effect of crude extract (TcE) and its different fractions on irritant contact dermatitis model in mice and verified its anti-inflammatory action mechanism. MATERIALS AND METHODS: The qualitative phytochemical analysis of TcE and its dichloromethane, n-butanol and ethyl acetate fractions was performed by UHPLC-ESI-HRMS...
November 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Veerakishore K Reddy, Naveen K Kommineni, Prathyusha Padakandla, Harshini Togaru, John P Indupalli, Swapna P Nanga
Aim: The goal of the study was to detect the presence of macrophage inflammatory protein (MIP)-1α and MIP-1β and to estimate their levels in gingival crevicular fluid (GCF) of children with Down syndrome. Materials and methods: MIP-1α and MIP-1β levels were estimated in GCF samples of 20 healthy and 20 Down syndrome individuals. Gingival status was assessed by measuring the gingival index (GI), plaque index (PI), clinical attachment level (CAL), and probing pocket depth (PPD)...
July 2018: International Journal of Clinical Pediatric Dentistry
Eyyüb Y Kıbış, I Esra Büyüktahtakın
In this paper we introduce a new mixed-integer linear programming (MIP) model that explicitly integrates the spread of cancer cells into a spatio-temporal reaction-diffusion model of cancer growth, while taking into account treatment effects. This linear but non-convex model appears to be the first of its kind by determining the optimal sequence of the typically prescribed cancer treatment methods-surgery (S), chemotherapy (C), and radiotherapy (R)-while minimizing the newly generated tumor cells for early-stage breast cancer in a unique three-dimensional (3D) spatio-temporal system...
October 30, 2018: Mathematical Biosciences
Maëva Cherif-Feildel, Clothilde Heude Berthelin, Beatrice Adeline, Guillaume Rivière, Pascal Favrel, Kristell Kellner
Insulin Related Peptides (IRPs) belong to the insulin superfamily and possess a typical structure with two chains, B and A, linked by disulphide bonds. As the sequence conservation is usually low between members, IRPs are classified according to the number and position of their disulphide bonds. In molluscan species, the first IRPs identified, named Molluscan Insulin-related Peptides (MIPs), exhibit four disulphide bonds. The genomic and transcriptomic data screening in the Pacific oyster Crassostrea gigas (Mollusc, Bivalvia) allowed us to identify six IRP sequences belonging to three structural groups...
October 30, 2018: General and Comparative Endocrinology
Ana R Cardoso, Ana C Marques, Lídia Santos, Alexandre F Carvalho, Florinda M Costa, Rodrigo Martins, M Goreti F Sales, Elvira Fortunato
Graphene has emerged as a novel material with enhanced electrical and structural properties that can be used for a multitude of applications from super-capacitors to biosensors. In this context, an ultra-sensitive biosensor was developed using a low-cost, simple and mask-free method based on laser-induced graphene technique for electrodes patterning. The graphene was produced on a polyimide substrate, showing a porous multi-layer structure with a resistivity of 102.4 ± 7.3 Ω/square. The biosensor was designed as a 3-electrode system...
October 14, 2018: Biosensors & Bioelectronics
Munir Mosaheb, Lee M Wetzler
Vaccines formulated with adjuvant have been effective against numerous infectious diseases, almost always due to induction of functional antibodies that recognizes the pathogen of interest. There is an unmet clinical need for vaccine adjuvants that induce T cells responses to potentially enhance protection against malignancies and intracellular pathogens, where a humoral response, alone, may not be adequate for protection. In this study, we demonstrate that a TLR2 ligand-based adjuvant, meningococcal PorB, has broad immunostimulatory activity with the ability to induce a robust and diverse vaccine antigen specific T cell response...
October 28, 2018: Vaccine
Ryoiti Kiyama, Yoshiyuki Furutani, Kayoko Kawaguchi, Toshio Nakanishi
Sparassis crispa (Hanabiratake) is a widely used medicinal mushroom in traditional Chinese medicine because it contains materials with pharmacological activity. Here, we report its 39.0-Mb genome, encoding 13,157 predicted genes, obtained using next-generation sequencing along with RNA-seq mapping data. A phylogenetic analysis by comparison with 25 other fungal genomes revealed that S. crispa diverged from Postia placenta, a brown-rot fungus, 94 million years ago. Several features specific to the genome were found, including the A-mating type locus with the predicted genes for HD1 and HD2 heterodomain transcription factors, the mitochondrial intermediate peptidase (MIP), and the B-mating type locus with seven potential pheromone receptor genes and three potential pheromone precursor genes...
October 30, 2018: Scientific Reports
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