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Zhe Jiao, Jingwen Li, Liangji Mo, Jinming Liang, Hongbo Fan
A molecularly imprinted polymer (MIP) was fabricated for selective recognition of the highly persistent pollutant perfluorooctane sulfonate (PFOS). The MIP was prepared from chitosan and doped with fluorescent carbon quantum dots (CQDs). It was characterized by fluorescence spectrophotometry, scanning electron microscopy, and Fourier transform infrared spectroscopy. The fluorescence of the CQDs, best measured at excitation/emission wavelengths of 350/460 nm, is enhanced by PFOS, and the effect is much stronger for the MIP than for the nonimprinted polymer (NIP)...
September 21, 2018: Mikrochimica Acta
Kenton J Johnston, Hefei Wen, Jason M Hockenberry, Karen E Joynt Maddox
Importance: Medicare is moving toward value-based payment. The Merit-Based Incentive Payment System (MIPS) program judges outpatient clinicians' performance on a measure of annual Medicare spending. However, this measure may disadvantage outpatient clinicians who care for vulnerable populations because the algorithm omits meaningful determinants of cost. Objectives: To determine whether factors not included in Medicare risk adjustment, including patient neuropsychological and functional status, as well as local area health resources and economic conditions, are associated with Medicare total annual cost of care (TACC), and evaluate whether accounting for these factors is associated with improved TACC performance by outpatient safety-net clinicians...
September 17, 2018: JAMA Internal Medicine
Omar S Ahmad, Thomas S Bedwell, Cem Esen, Alvaro Garcia-Cruz, Sergey A Piletsky
Molecular imprinting is the process of template-induced formation of specific recognition sites in a polymer. Synthetic receptors prepared using molecular imprinting possess a unique combination of properties such as robustness, high affinity, specificity, and low-cost production, which makes them attractive alternatives to natural receptors. Improvements in polymer science and nanotechnology have contributed to enhanced performance of molecularly imprinted polymer (MIP) sensors. Encouragingly, recent years have seen an increase in high-quality publications describing MIP sensors for the determination of biomolecules, drugs of abuse, and explosives, driving toward applications of this technology in medical and forensic diagnostics...
September 18, 2018: Trends in Biotechnology
Joey Berlin
Physicians finally see how they fared in the first year of Medicare's "MIPS" quality payment program.
September 1, 2018: Texas Medicine
Min Chang, Zhiqiang Zhang, Xuedian Zhang, Menghui He, Zhijie Qiu, Jian Xu
In this article, an operation strategy of digital micromirror device (DMD) and the maximum intensity projection (MIP) image processing method are proposed to improve the contrast of images in confocal microscopy. First, the configuration of DMD is demonstrated and the effect of scanning unit size on image performance is analyzed. Then, the image processing method MIP is applied. According to the MIP method, only the maximum intensity projection point of the same pixel is chosen from every image, and the maximum intensity projection point exactly corresponds to the positon where mirror is at "on" position during the scanning process in DMD-based confocal microscope system,...
September 20, 2018: Microscopy Research and Technique
Wen Zhang, Tianqi Zhang, Yun Chen
Cytochrome c (Cyt c) plays an important role in cell apoptosis. However, it could be functionally compromised by interaction with anti-apoptosis proteins, known as protein-protein interactions (PPIs). Among the proteins potentially interacting with Cyt c, both HSP27 and Bcl-xL serve as pivotal anti-apoptosis proteins. Because multiple PPIs, especially those involve the same protein, could affect each other, their simultaneous and quantitative detection is highly needed. In this study, a combined approach of molecularly imprinted polymers (MIPs) and LC-MS/MS-based targeted proteomics was developed for simultaneous quantification of Cyt c-HSP27 and Cyt c-Bcl-xL interactions...
September 17, 2018: Journal of Proteomics
Taira Kajisa, Toshiya Sakata
A platform based on a highly selective and sensitive detection device functionalized with a well-designed artificial biointerface is required for versatile biosensors. We develop a molecularly imprinted polymer (MIP)-coated gate field-effect transistor (FET) biosensor for low-concentration-glucose detection in biological fluid samples such as tears in an enzyme-free manner. The MIP includes glucose templates (GluMIP), in which glucose binds to vinylphenylboronic acid (VPBA) in the copolymerized membrane resulting in the change in the density of molecular charges of the PBA/glucose complex...
September 20, 2018: ACS Applied Materials & Interfaces
Yi Zhang, Hui Guo, Brian Chi-Yan Cheng, Tao Su, Xiu-Qiong Fu, Ting Li, Pei-Li Zhu, Kai-Wing Tse, Si-Yuan Pan, Zhi-Ling Yu
Background: Dingchuan tang (asthma-relieving decoction), a formula of nine herbs, has been used for treating respiratory inflammatory diseases for >400 years in the People's Republic of China. However, the mechanisms underlying the anti-inflammatory action of dingchuan tang is not fully understood. This study aims to investigate the effects of Dingchuan tang essential oil (DCEO) on inflammatory mediators and the underlying mechanism of action. Materials and methods: DCEO was extracted by steam distillation...
2018: Drug Design, Development and Therapy
Daojin Li, Qi Yuan, Wenliu Yang, Mengke Yang, Shihui Li, Tianyong Tu
Vitamin B12 (VB12) has an important function in human physiology. However, analysis of VB12 at natural levels in foods or biological samples is difficult because of its very low concentration level and the presence of high-abundance components which can interfere with the measuring system. Thus, it is essential to develop efficient and selective enrichment approaches for VB12. Molecularly imprinted polymers (MIPs) have important applications from separation and sensing to catalysis. However, there is no report on the preparation of MIPs for VB12...
September 16, 2018: Analytical Biochemistry
Gerwyn Morris, Brisa S Fernandes, Basant K Puri, Adam J Walker, Andre F Carvalho, Michael Berk
BACKGROUND: The blood-brain barrier acts as a highly regulated interface; its dysfunction may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders. METHODS: In this narrative review, focussing on redox, inflammatory and mitochondrial pathways and their effects on the blood-brain barrier, a model is proposed detailing mechanisms which might explain how increases in blood-brain barrier permeability occur and can be maintained with increasing inflammatory and oxidative and nitrosative stress being the initial drivers...
October 2018: Australian and New Zealand Journal of Psychiatry
Jingjing Yang, Le Yang, Lei Tian, Xiaofang Ji, Lin Yang, Liying Li
BACKGROUND/AIMS: Macrophages, the most plastic cells in the haematopoietic system, are found in all tissues and show great functional heterogeneity. Sphingosine 1-phosphate (S1P)/ S1P receptors (S1PRs) system is widely involved in the process of inflammatory disease, whereas little evidence concerning its role in functional macrophage polarization is available. Thus, the present study was designed to evaluate the effects of S1P/S1PRs on functional polarization of macrophage in mouse bone marrow (BM)-derived monocyte/macrophages (BMMs)...
September 19, 2018: Cellular Physiology and Biochemistry
Xue Wang, Jin-Zhi Wang, Jian-Bin Li, Ying-Jie Zhang, Feng-Xiang Li, Wei Wang, Yan-Luan Guo, Qian Shao, Min Xu, Xi-Jun Liu, Yue Wang
BACKGROUND: Concurrent chemoradiotherapy is considered curative intent treatment for patients with non-operative esophageal cancer. Radiation-induced heart damage receives much attention. We performed repeated four-dimensional computed tomography (4DCT) to detect changes in cardiac volume during radiotherapy for esophageal cancer patients, and explored potential factors responsible for those changes. METHODS: Forty-six patients with esophageal cancer underwent enhanced 4DCT and three-dimensional (3D) CT scans before radiotherapy and every 10 fractions during treatment...
September 18, 2018: Radiation Oncology
Charlene M Kahler, Mitali Sarkar-Tyson, Emily A Kibble, Keith A Stubbs, Alice Vrielink
Society has benefitted greatly from the use of antibiotics. Unfortunately, the misuse of these valuable molecules has resulted in increased levels of antibiotic resistance, a major global and public health issue. This resistance and the reliance on a small number of biological targets for the development of antibiotics emphasizes the need for new targets. A critical aspect guiding the development of new antimicrobials through a rational structure-guided approach is to understand the molecular structures of specific biological targets of interest...
September 14, 2018: Current Opinion in Structural Biology
Esra Nizam, Nuray Erin
INTRODUCTION: The biological action of Substance P (SP) is mediated mainly by NK-1 receptors (NK1R) followed by NK2 receptors (NK2R). Aberrant expression of NK1R and NK2R has been identified in various carcinomas. The role of Substance P and its receptors, especially NK2R in cancer progression is not entirely known and there are conflicting results in the literature demonstrating the need for further investigation. In the current study, we examined the effects of SP and antagonists selective for the NK1R and NK2R in breast carcinoma cells metastasize to vital organs...
September 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Paulina Gronesova, Danka Cholujova, Katarina Kozic, Michaela Korbuly, Miroslav Vlcek, Adela Penesova, Richard Imrich, Jan Sedlak, Luba Hunakova
The aim of our prospective, interventional, pre-post, single arm study was to supplement the lack of knowledge of the effect of short-term Pilates intervention on selected blood parameters of healthy women. Female volunteers were recruited for 2-weeks Pilates intervention. Blood has been collected and anthropometric parameters were measured before and after exercise period (EP). Plasma insulin, cortisol, and dehydroepiandrosterone sulphate levels, erythrocyte antioxidant activity, glutathione levels, NK cytotoxicity and plasma cytokines were analysed...
July 2018: General Physiology and Biophysics
Jinghua Wang, Guoping Wu, Brian Manick, Vida Hernandez, Mark Renelt, Christian Erickson, Joanna Guan, Ravinder Singh, Simone Rollins, Alicia Solorz, Ming Bi, Jun Li, David Grabowski, Janette Dirkx, Camrin Tracy, Thomas Stuart, Chad Ellinghuysen, Daniel Desmond, Craig Foster, Vassilios Kalabokis
B7 family members and their receptors play a central role in the regulation of T cell responses through T cell costimulation and coinhibition pathways that constitute very attractive targets for the development of immunotherapeutic drugs. In this study, we report that VSIG-3/IGSF11 is a ligand of B7 family member VISTA/PD-1H and inhibits human T cell functions through a novel VSIG-3/VISTA pathway. An extensive functional ELISA binding screening assay reveals that VSIG-3 does bind to the new B7 family member VISTA but does not interact with other known members of the B7 family...
September 16, 2018: Immunology
Ilgım Göktürk, Emel Tamahkar, Fatma Yılmaz, Adil Denizli
In this study, we have reported a novel fabrication technique for human serum albumin (HSA) imprinted composite bacterial cellulose nanofibers (MIP-cBCNFs) used for the depletion of HSA selectively from artificial blood plasma for proteomic applications. Molecular imprinting was achieved by using metal ion coordination interactions of N‑methacryloyl‑(l)‑histidinemethylester (MAH) monomer and Cu(II) ions. MAH-Cu(II)-HSA complex was polymerized with bacterial cellulose nanofibers (BCNFs) under constant stirring at room temperature...
August 29, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Mahmoud Roushani, Zeynab Jalilian, Azizollah Nezhadali
A novel molecularly imprinted polymer sensor for fast and direct determination of trazosine (TR) was studied. The voltammetric sensor based on molecularly imprinted polymer (MIP) with disposable gold nanoparticles modified screen printed carbon electrode (MIP/AuNPs/SPCE) is developed for the determination of TR. Under the optimum conditions, the peak current of the sensor and TR concentration showed a good linear relationship over the range from 2.0 to 250.0 μM, with a low detection limit (S/N = 3) of 0...
September 7, 2018: Colloids and Surfaces. B, Biointerfaces
Britta Stapel, Irina Sieve, Christine S Falk, Stefan Bleich, Denise Hilfiker-Kleiner, Kai G Kahl
Schizophrenia and major depression are associated with alterations in peripheral inflammatory markers, and anti-inflammatory therapy has been proposed as a promising add-on approach in the pharmacologic treatment of both disorders. Second-generation atypical antipsychotics are currently first-line drugs in the treatment of schizophrenia and are also used as augmentation strategies in treatment-resistant major depression. Furthermore, these drugs have been reported to exhibit distinct metabolic side effects and to influence inflammatory processes...
September 4, 2018: Journal of Psychiatric Research
Lola Butcher
The pay-for-value movement could justify rewarding-and punishing-doctors based on quality scores. PROBLEM: Hardly anyone likes the current ways quality is measured, especially physicians. Few believe that Medicare's Merit-based Incentive Payment System (MIPS) will clear things up. In fact, it might cause more confusion.
September 2018: Managed Care
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