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https://www.readbyqxmd.com/read/28811023/agnps-3d-nanostructure-enhanced-electrochemiluminescence-of-cdse-quantum-dot-coupled-with-strand-displacement-amplification-for-sensitive-biosensing-of-dna
#1
Meng Jiao, Guifen Jie, Lu Tan, Shuyan Niu
A novel strategy using Ag nanoparticles-3D (AgNPs-3D) nanostructure enhanced electrochemiluminescence (ECL) of CdSe quantum dots (QDs) coupled with strand displacement amplification (SDA) for sensitive biosensing of DNA was successfully designed. The prepared CdSe QDs with intense ECL were assembled on the poly (diallyldimethylammonium chloride) (PDDA) graphene oxide (GO) nanocomposites modified electrode, then gold nanoparticles (NPs) as the quenching probe was conjugated to the QDs, ECL signal was efficiently quenched...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28806061/construction-of-a-polyhedral-dna-12-arm-junction-for-self-assembly-of-wireframe-dna-lattices
#2
Ilenia Manuguerra, Guido Grossi, Rasmus P Thomsen, Jeppe Lyngsø, Jan Skov Pedersen, Jørgen Kjems, Ebbe Sloth Andersen, Kurt Vesterager Gothelf
A variety of different tiles for the construction of DNA lattices have been developed since the structural DNA nanotechnology field was born. The majority of these are designed for the realization of close-packed structures where DNA helices are arranged in parallel and tiles are connected through sticky ends. Assembly of such structures requires to the use of cation rich buffers to minimize repulsion between parallel helices, which poses limits to the application of DNA nanostructures. Wireframe structures on the other hand are less susceptible to salt concentration, but the assembly of wireframe lattices is limited by the availability of tiles and 2 motifs...
August 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28797972/recent-applications-of-plga-based-nanostructures-in-drug-delivery
#3
REVIEW
Maria Mir, Naveed Ahmed, Asim Ur Rehman
Over the years, issues associated with non-biodegradable polymers have paved the way for biodegradable polymers in the domain of pharmaceutical and biomedical sciences. Poly (lactic-co-glycolic acid) (PLGA) is considered one of the most thrivingly synthesized biodegradable polymers. To formulate polymeric nanostructures, PLGA has attained noteworthy attention due to its controllable properties, complete biodegradability and biocompatibility, well defined formulation techniques and easy processing. This review focuses on fabrication techniques of PLGA based nanostructures and their advanced biomedical applications covering drug delivery and in-vivo imaging...
July 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28794955/self-assembly-of-g-rich-oligonucleotides-incorporating-a-3-3-inversion-of-polarity-site-a-new-route-towards-g-wire-dna-nanostructures
#4
Giorgia Oliviero, Stefano D'Errico, Brunella Pinto, Fabrizia Nici, Principia Dardano, Ilaria Rea, Luca De Stefano, Luciano Mayol, Gennaro Piccialli, Nicola Borbone
Obtaining DNA nanostructures with potential applications in drug discovery, diagnostics, and electronics in a simple and affordable way represents one of the hottest topics in nanotechnological and medical sciences. Herein, we report a novel strategy to obtain structurally homogeneous DNA G-wire nanostructures of known length, starting from the short unmodified G-rich oligonucleotide d(5'-CGGT-3'-3'-GGC-5') (1) incorporating a 3'-3' inversion of polarity site. The reported approach allowed us to obtain long G-wire assemblies through 5'-5' π-π stacking interactions in between the tetramolecular G-quadruplex building blocks that form when 1 is annealed in the presence of potassium ions...
August 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28792637/modulation-of-chondrocyte-motility-by-tetrahedral-dna-nanostructures
#5
Sirong Shi, Shiyu Lin, Xiaoru Shao, Qianshun Li, Zhang Tao, Yunfeng Lin
OBJECTIVES: Contemporarily, a highly increasing attention was paid to nanoconstructs, particularly DNA nanostructures possessing precise organization, functional manipulation, biocompatibility and biodegradability. Amongst these DNA nanomaterials, tetrahedral DNA nanostructures (TDNs) are a significantly ideal bionanomaterials with focusing on the property that can be internalized into cytoplasm in the absence of transfection. Therefore, the focus of this study was on investigating the influence of TDNs on the chondrocytes locomotion...
August 9, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28792224/supramolecular-protein-assemblies-based-on-dna-templates
#6
Chunxi Hou, Shuwen Guan, Ruidi Wang, Wei Zhang, Fanchao Meng, Linlu Zhao, Jiayun Xu, Junqiu Liu
DNA plays an important role in the process of protein assembly. DNA viruses such as M13 virus are typical examples in which single DNA genome behaves as template to induce multiple major coat protein (PⅧ) monomers assembling. Thus, design of protein assemblies based on DNA templatesattracts much interest in construction of supramolecular structructures and materials. With the development of DNA nanotechnology, precise 1D and 3D protein nanostructures have been designed and constructed by using DNA templates through DNA-protein interactions, protein-ligand interactions and protein-adapter interactions...
August 9, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28783216/sensitive-quantitative-naked-eye-biodetection-with-polyhedral-cu-nanoshells
#7
Jae-Ho Kim, Jeong-Eun Park, Mouhong Lin, Sungi Kim, Gyeong-Hwan Kim, SungJun Park, GwangPyo Ko, Jwa-Min Nam
One of the most heavily used methods in chemical and biological labeling, detection, and imaging is based on silver shell-based enhancement on Au nanoparticles (AuNPs) that is useful for amplifying Rayleigh scattering, colorimetric signal, surface-enhanced Raman scattering, and electrical signal, but poor structural controllability and nonspecific growth of silver shells have limited its applications, especially with respect to signal reproducibility and quantification. Here, a highly specific, well-defined Cu nanopolyhedral shell overgrowth chemistry is developed with the aid of polyethyleneimine (PEI) on AuNPs, and the use of this PEI-mediated Cu polyhedral nanoshell (CuP) chemistry is shown as a means of light-scattering signal enhancement for the development of naked-eye-based highly sensitive and quantitative detections of DNA and viruses...
August 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28778062/dna-aptamer-functionalized-gold-nanostructures-for-molecular-recognition-and-photothermal-inactivation-of-methicillin-resistant-staphylococcus-aureus
#8
Ismail Ocsoy, Sadi Yusufbeyoglu, Vedat Yılmaz, Eric S McLamore, Nilay Ildız, Ahmet Ülgen
In this work, we report the development of DNA aptamer-functionalized gold nanoparticles (Apt@Au NPs) and gold nanorods (Apt@Au NRs) for inactivation of Methicillin-resistant Staphylococcus aureus (MRSA) with targeted photothermal therapy (PTT). Although both Apt@Au NPs and Apt@Au NRs specifically bind to MRSA cells, Apt@Au NPs and Apt@Au NRs inactivated ∼5% and over 95% of the cells,respectively through PTT. This difference in inactivation was based on the relatively high longitudinal absorption of near-infrared (NIR) radiation and strong photothermal conversion capability for the Apt@Au NRs compared to the Apt@Au NPs...
July 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28777539/stoichiometry-and-dispersity-of-dna-nanostructures-using-photobleaching-pair-correlation-analysis
#9
Amani A Hariri, Graham D Hamblin, Jack S Hardwick, Robert Godin, Jean-Francois Desjardins, Paul W Wiseman, Hanadi F Sleiman, Gonzalo Cosa
A wide variety of approaches have become available for fabricating nanomaterials with increasing degrees of complexity, precision, and speed while minimizing cost. Their quantitative characterization however remains a challenge. Analytical methods to better inspect and validate the structure/composition of large nanoscale objects are required to optimize their applications in diverse technologies. Here we describe single molecule fluorescence-based strategies relying on photobleaching and multiple color colocalization features toward the characterization of supramolecular structures...
August 4, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28773087/improved-gene-transfer-with-functionalized-hollow-mesoporous-silica-nanoparticles-of-reduced-cytotoxicity
#10
Zhengwen Zhan, Xiaoxu Zhang, Jiayuan Huang, Ying Huang, Zhengwei Huang, Xin Pan, Guilan Quan, Hu Liu, Lili Wang, And Chuanbin Wu
Gene therapy is a promising strategy for treatment of genetically caused diseases. Successful gene delivery requires an efficient carrier to transfer the desired gene into host cells. Recently, mesoporous silica nanoparticles (MSNs) functionalized with 25 kD polyethyleneimine (PEI) were extensively used as gene delivery carriers. However, 25 kD PEI could significantly reduce the safety of the modified MSNs although it is efficient for intracellular delivery of nucleic acids. In addition, limited drug loading remains a challenge for conventional MSNs drug carriers...
June 30, 2017: Materials
https://www.readbyqxmd.com/read/28771915/dna-arrays-with-a-silver-lining
#11
Arun Richard Chandrasekaran
The development of molecular electronics is one of the current focuses of bottom-up nanotechnology. DNA has been the building block for nanostructures with a variety of applications, with its use extended to the formation of conducting nanowires. The one-dimensional silver/DNA hybrid arrays reported recently is a step towards achieving longer DNA nanowires.
August 3, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28759199/tio2-bivo4-heterostructure-to-enhance-photoelectrochemical-efficiency-for-sensitive-aptasensing
#12
Pei Pei Liu, Xiaoqiang Liu, Xiao He Huo, Yunfei Tang, Jun Xu, Huangxian Ju
This work designed a nanocomposite to enhance the photoelectrochemical (PEC) efficiency by depositing BiVO4 nanoparticles on TiO2 nanospheres with a solvothermal method. The TiO2-BiVO4 heterostructure was characterized with various spectroscopic and microscopic techniques and was employed as a nanostructured support to cross-link DNA aptamer for constructing a visible-light driven PEC aptasensor. The TiO2 nanospheres provided a biocompatible microenvironment, and the high surface area of the heterostructure enhanced the loading of aptamer molecules...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28754968/dna-self-assembly-catalyzed-by-artificial-agents
#13
Chao Shi, Yifan Wang, Menghua Zhang, Cuiping Ma
Nucleic acids have been shown to be versatile molecules and engineered to produce various nanostructures. However, the poor rate of these uncatalyzed nucleic acid reactions has restricted the development and applications. Herein, we reported a novel finding that DNA self-assembly could be nonenzymatically catalyzed by artificial agents with an increasing dissociation rate constant K2. The catalytic role of several artificial agents in DNA self-assembly was verified by real-time fluorescent detection or agarose gel electrophoresis...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28754539/in-vitro-genotoxicity-and-cytotoxicity-of-polydopamine-coated-magnetic-nanostructures
#14
Anna Woźniak, Magdalena Walawender, Dominika Tempka, Emerson Coy, Karol Załęski, Bartosz F Grześkowiak, Radosław Mrówczyński
Synthesis of magnetic nanoparticles and magnetic nanoclusters was performed by the co-precipitation method or solvothermal synthesis, respectively, followed by oxidative polymerization of dopamine, resulting in a polydopamine (PDA) shell. The nanomaterials obtained were described using TEM, FTIR and magnetic measurements. For the first time, cyto- and genotoxicity studies of polydopamine-coated nanostructures were performed on cancer and normal cell lines, providing in-depth insight into the toxicity of such materials...
July 25, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28745060/tunable-fluorescence-of-a-semiconducting-polythiophene-positioned-on-dna-origami
#15
Johanna Zessin, Franziska Fischer, Andreas Heerwig, Alfred Kick, Susanne Boye, Manfred Stamm, Anton Kiriy, Michael Mertig
A novel approach for the integration of π-conjugated polymers (CPs) into DNA-based nanostructures is presented. Using the controlled Kumada catalyst-transfer polycondensation, well-defined thiophene-based polymers with controllable molecular weight, specific end groups, and water-soluble oligoethylene glycol-based side chains were synthesized. The end groups were used for the easy but highly efficient click chemistry-based attachment of end-functionalized oligodeoxynucleotides (ODNs) with predesigned sequences...
July 27, 2017: Nano Letters
https://www.readbyqxmd.com/read/28738641/an-interference-free-and-label-free-sandwich-type-magnetic-silicon-microsphere-rgo-based-probe-for-fluorescence-detection-of-microrna
#16
Shiyu Li, Kui He, Rong Liao, Chunyan Chen, Xiaoming Chen, Changqun Cai
An interference-free and label-free sensing platform was developed for the highly sensitive detection of microRNA-21 (miRNA-21) in vitro by magnetic silicon microsphere (MNP)-reduced graphene oxide (rGO)-based sandwich probe. In this method, DNA capture probes (P1) were connected with MNPs at the 5' end and hybridized with completely complementary target miRNA. Subsequently, rGO was retained and induced the fluorescence quenching in the supernatant. Through the magnetic separation, the supernatant environment was simplified and the interference to analytical signal was eliminated...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738444/protein-coating-of-dna-nanostructures-for-enhanced-stability-and-immunocompatibility
#17
Henni Auvinen, Hongbo Zhang, Nonappa, Alisa Kopilow, Elina H Niemelä, Sami Nummelin, Alexandra Correia, Hélder A Santos, Veikko Linko, Mauri A Kostiainen
Fully addressable DNA nanostructures, especially DNA origami, possess huge potential to serve as inherently biocompatible and versatile molecular platforms. However, their use as delivery vehicles in therapeutics is compromised by their low stability and poor transfection rates. This study shows that DNA origami can be coated by precisely defined one-to-one protein-dendron conjugates to tackle the aforementioned issues. The dendron part of the conjugate serves as a cationic binding domain that attaches to the negatively charged DNA origami surface via electrostatic interactions...
July 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28732964/ultrasonic-effect-on-ruo2-nanostructures-prepared-by-direct-calcination-of-two-new-ru-ii-organic-supramolecular-polymers
#18
Chang Jin, Fahime Bigdeli, Zhi-Min Jin, Yong-Rong Xie, Mao-Lin Hu, Ali Morsali
Two novel Ru(II) complexes [(η(6)-p-cymene)RuCl(L1)]PF6 (R1) and [(η(6)-C6H6)RuCl(L1)]PF6 (R3) with ligand (E)-4-(methylthio)-N-((quinolin-2-yl)methylene)benzenamine (L1), were synthesized and investigated using elemental analysis, IR, (1)H NMR, (13)C NMR spectroscopy and X-ray crystallography. Complexes R1 and R3 have coordination environments with formulated (η(6)-p-cymene)Ru(N2Cl) and (η(6)-C6H6)Ru(N2Cl) respectively. The thermal stabilities of compounds R1 and R3 were studied by thermal gravimetric (TG) and differential scanning calorimetry (DSC)...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28731700/nanomanipulation-of-individual-dna-molecules-covered-by-single-layered-reduced-graphene-oxide-sheets-on-a-solid-substrate
#19
Ying Wang, Yue Shen, Bin Li, Shuo Wang, Jinjin Zhang, Yi Zhang, Jun Hu
Nanomanipulation of single DNA molecules has great potential in fundamental genetic research and clinical analysis, and is a good model system for studying the interfacial effects on physiochemical processes, which occur when manipulating the linear DNA molecules with an atomic force microscope (AFM) tip. Here, we demonstrate that AFM nanomanipulation can be carried out on DNA molecules covered by a single-layered reduced graphene oxide sheet. Nanomanipulation, which includes cutting, pushing, and sweeping operations, specific to the covered DNA molecules can be achieved in a well-controlled manner using AFM in the PeakForce Quantitative Nano-Mechanics mode...
August 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28731332/tuning-the-cavity-size-and-chirality-of-self-assembling-3d-dna-crystals
#20
Chad R Simmons, Fei Zhang, Tara MacCulloch, Noureddine Fahmi, Nicholas Stephanopoulos, Yan Liu, Nadrian C Seeman, Hao Yan
The foundational goal of structural DNA nanotechnology-the field that uses oligonucleotides as a molecular building block for the programmable self-assembly of nanostructured systems-was to use DNA to construct three-dimensional (3D) lattices for solving macromolecular structures. The programmable nature of DNA makes it an ideal system for rationally constructing self-assembled crystals and immobilizing guest molecules in a repeating 3D array through their specific stereospatial interactions with the scaffold...
August 16, 2017: Journal of the American Chemical Society
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