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https://www.readbyqxmd.com/read/28651051/molecular-precision-at-micrometer-length-scales-hierarchical-assembly-of-dna-protein-nanostructures
#1
Daniel Schiffels, Veronika A Szalai, J Alexander Liddle
Robust self-assembly across length scales is a ubiquitous feature of biological systems, but remains challenging for synthetic structures. Taking a cue from biology - where disparate molecules work together to produce large, functional assemblies - we demonstrate how to engineer microscale structures with nanoscale features: Our self-assembly approach begins by using DNA polymerase to controllably create double-stranded DNA (dsDNA) sections on a single-stranded template. The single-stranded DNA (ssDNA) sections are then folded into a mechanically flexible skeleton by the origami method...
June 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28645043/in-vitro-and-in-vivo-behavior-of-dna-tetrahedrons-as-tumor-targeting-nanocarriers-for-doxorubicin-delivery
#2
Ji Hee Kang, Kyoung-Ran Kim, Hyukjin Lee, Dae-Ro Ahn, Young Tag Ko
Deoxyribonucleic acid (DNA) is a versatile material with high applicability and inherent biocompatibility. L-DNA, the perfect mirror form of the naturally occurring D-DNA, has been used in DNA nanotechnology. It has thermodynamically identical properties to D-DNA, is capable of self-assembly and bio-orthogonal base-pairing, and is resistant to nuclease activity. We previously constructed an L-DNA tetrahedron (L-Td) and found that this nanostructure has remarkably higher capacity for cell penetration than its natural counterpart (D-Td)...
June 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28636320/dna-loading-and-release-using-custom-tailored-poly-l-lysine-surfaces
#3
Amin Shakiba, Sagar L Patil, Oussama Zenasni, Monika E Schmitt, Preethi H Gunaratne, T Randall Lee
This manuscript describes the generation and study of surfaces modified with custom-crafted poly(L-lysine) (PLL) coatings for use in the loading and delivery of single-stranded DNA (ssDNA). The experimental strategy utilizes bidentate dithiol adsorbates to generate stably-bound azide-terminated self-assembled monolayers (SAMs) on gold possessing an oligo(ethylene glycol) (OEG) spacer. Consequent to the molecular assembly on gold, the azide termini are covalently attached to a maleimide linker moiety via a copper-catalyzed azide-alkyne "click" reaction...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28627887/controlling-the-catalytic-functions-of-dnazymes-within-constitutional-dynamic-networks-of-dna-nanostructures
#4
Shan Wang, Liang Yue, Zohar Shpilt, Alessandro Cecconello, Jason S Kahn, Jean-Marie Lehn, Itamar Willner
Mimicking complex cellular dynamic chemical networks being up-regulated or down-regulated by external triggers is one of the challenges in system chemistry. Constitutional dynamic networks, CDNs, composed of exchangeable components that respond to environmental triggers by self-adaption, provide general means to mimic biosystems. We use the structural and functional information encoded in nucleic acid nanostructures to construct effector (input)-triggered constitutional dynamic networks that reveal adaptable catalytic properties...
June 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28620911/distortion-of-dna-origami-on-graphene-imaged-with-advanced-tem-techniques
#5
Yoones Kabiri, Adithya N Ananth, Jaco van der Torre, Allard Katan, Jin-Yong Hong, Sairam Malladi, Jing Kong, Henny Zandbergen, Cees Dekker
While graphene may appear to be the ultimate support membrane for transmission electron microscopy (TEM) imaging of DNA nanostructures, very little is known if it poses an advantage over conventional carbon supports in terms of resolution and contrast. Microscopic investigations are carried out on DNA origami nanoplates that are supported onto freestanding graphene, using advanced TEM techniques, including a new dark-field technique that is recently developed in our lab. TEM images of stained and unstained DNA origami are presented with high contrast on both graphene and amorphous carbon membranes...
June 16, 2017: Small
https://www.readbyqxmd.com/read/28618781/cavity-type-dna-origami-based-plasmonic-nanostructures-for-raman-enhancement
#6
Mengzhen Zhao, Xu Wang, Shaokang Ren, Yikang Xing, Jun Wang, Nan Teng, Dongxia Zhao, Wei Liu, Dan Zhu, Shao Su, Jiye Shi, Shiping Song, Lihua Wang, Jie Chao, Lianhui Wang
DNA origami has been established as addressable templates for site-specific anchoring of gold nanoparticles (AuNPs). Given that AuNPs are assembled by charged DNA oligonucleotides, it is important to reduce the charge repulsion between AuNPs-DNA and the template to realize high yields. Herein, we developed a cavity-type DNA origami as templates to organize 30-nm AuNPs, which formed dimer and tetramer plasmonic nanostructures. Transmission electron microscopy (TEM) images showed that high yields of dimer and tetramer plasmonic nanostructures were obtained by using the cavity-type DNA origami as the template...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28617516/incorporation-of-native-antibodies-and-fc-fusion-proteins-on-dna-nanostructures-via-a-modular-conjugation-strategy
#7
Bas J H M Rosier, Glenn A O Cremers, Wouter Engelen, Maarten Merkx, Luc Brunsveld, Tom F A de Greef
A photocrosslinkable protein G variant was used as an adapter protein to covalently and site-specifically conjugate an antibody and an Fc-fusion protein to an oligonucleotide. This modular approach enables straightforward decoration of DNA nanostructures with complex native proteins while retaining their innate binding affinity, allowing precise control over the nanoscale spatial organization of such proteins for in vitro and in vivo biomedical applications.
June 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28609719/near-infrared-photoluminescence-biosensing-platform-with-gold-nanorods-over-gallium-arsenide-nanohorn-array
#8
Yiming Zhang, Tao Jiang, Longhua Tang
The near-infrared (NIR) optical detection of biomolecules with high sensitivity and reliability have been expected, however, it is still a challenge. In this work, we present a gold nanorods (AuNRs)-over-gallium arsenide nanohorn-like array (GaAs NHA) system that can be used for the ultrasensitive and specific NIR photoluminescence (PL) detection of DNA and proteins. The fabrication of GaAs NHA involved the technique of colloidal lithography and inductively coupled plasma dry etching, yielding large-area and well-defined nanostructural array, and exhibiting an improved PL emission compared to the planar GaAs substrate...
June 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28609612/diverse-supramolecular-nanofiber-networks-assembled-by-functional-low-complexity-domains
#9
Bolin An, Xinyu Wang, Mengkui Cui, Xinrui Gui, Xiuhai Mao, Yan Liu, Ke Li, Cenfeng Chu, Jiahua Pu, Susu Ren, Yanyi Wang, Guisheng Zhong, Timothy K Lu, Cong Liu, Chao Zhong
Self-assembling supramolecular nanofibers, common in the natural world, are of fundamental interest and technical importance to both nanotechnology and materials science. Despite important advances, synthetic nanofibers still lack the structural and functional diversity of biological molecules, and the controlled assembly of one type of molecule into a variety of fibrous structures with wide-ranging functional attributes remains challenging. Here, we harness the low-complexity (LC) sequence domain of fused in sarcoma (FUS) protein, an essential cellular nuclear protein with slow kinetics of amyloid fiber assembly, to construct random copolymer-like, multi-block and self-sorted supramolecular fibrous networks with distinct structural features and fluorescent functionalities...
June 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28608630/precisely-tailored-dna-nanostructures-and-their-theranostic-applications
#10
REVIEW
Bing Zhu, Lihua Wang, Jiang Li, Chunhai Fan
A critical challenge in nanotechnology is the limited precision and controllability of the structural parameters, which brings about concerns in uniformity, reproducibility and performance. Self-assembled DNA nanostructures, as a newly emerged type of nano-biomaterials, possess low-nanometer precision, excellent programmability and addressability. They can precisely arrange various molecules and materials to form spatially ordered complex, resulting in unambiguous physical or chemical properties. Because of these, DNA nanostructures have shown great promise in numerous biomedical theranostic applications...
June 13, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28605177/dna-origami-scaffolds-for-creating-higher-order-structures
#11
Fan Hong, Fei Zhang, Yan Liu, Hao Yan
DNA has become one of the most extensively used molecular building blocks for engineering self-assembling materials. DNA origami is a technique that uses hundreds of short DNA oligonucleotides, called staple strands, to fold a long single-stranded DNA, which is called a scaffold strand, into various designer nanoscale architectures. DNA origami has dramatically improved the complexity and scalability of DNA nanostructures. Due to its high degree of customization and spatial addressability, DNA origami provides a versatile platform with which to engineer nanoscale structures and devices that can sense, compute, and actuate...
June 12, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28601788/carbon-nanostructures-as-immobilization-platform-for-dna-a-review-on-current-progress-in-electrochemical-dna-sensors
#12
REVIEW
P Abdul Rasheed, N Sandhyarani
Development of a sensitive, specific and cost-effective DNA detection method is motivated by increasing demand for the early stage diagnosis of genetic diseases. Recent developments in the design and fabrication of efficient sensor platforms based on nanostructures make the highly sensitive sensors which could indicate very low detection limit to the level of few molecules, a realistic possibility. Electrochemical detection methods are widely used in DNA diagnostics as it provide simple, accurate and inexpensive platform for DNA detection...
June 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28598482/correction-structural-stability-of-dna-origami-nanostructures-in-the-presence-of-chaotropic-agents
#13
Saminathan Ramakrishnan, Georg Krainer, Guido Grundmeier, Michael Schlierf, Adrian Keller
Correction for 'Structural stability of DNA origami nanostructures in the presence of chaotropic agents' by Saminathan Ramakrishnan et al., Nanoscale, 2016, 8, 10398-10405.
June 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28590544/optically-triggered-melting-of-dna-on-individual-semiconducting-carbon-nanotubes
#14
YuHuang Wang, Chunyan Wang, Brendan Meany
Optical excitation of nanostructures is known to induce local heating, a phenomenon that has been intensely exploited for drug release, gene delivery, cancer thermotherapy, and energy harvesting. However, the effect is typically small requiring collective heating of a large concentration or aggregates of particles. Here we show that optical excitation of individual semiconducting single-walled carbon nanotubes triggers strongly localized heating adequate to melt non-covalently attached double-stranded oligonucleotides in solution...
June 7, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28584334/-nanogold-biological-effects-and-occupational-exposure-levels
#15
Anna Maria Świdwińska-Gajewska, Sławomir Czerczak
Nanogold has different properties and biological activity compared to metallic gold. It can be applied in many fields, such as medicine, laboratory diagnostics and electronics. Studies on laboratory animals show that nanogold can be absorbed by inhalation and ingestion. It can penetrate deep into the epidermis and dermis, but there is no evidence that it is absorbed through the skin. Gold nanoobjects accumulate mainly in the liver and spleen, but they can also reach other internal organs. Nanogold can cross the blood-brain and blood-placenta barriers...
May 9, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28581004/dna-origami-gold-nanorod-hybrid-nanostructures-for-the-circumvention-of-drug-resistance
#16
Linlin Song, Qiao Jiang, Jianbing Liu, Na Li, Qing Liu, Luru Dai, Yuan Gao, Weili Liu, Dongsheng Liu, Baoquan Ding
We herein demonstrate that DNA origami can work as a multifunctional platform integrating a chemotherapeutic drug (doxorubicin), gold nanorods and a tumour-specific aptamer MUC-1, to realize the effective circumvention of drug resistance. Doxorubicin (DOX) was loaded efficiently onto DNA origami through base pair intercalation and surface-modified gold nanorods (AuNRs) were assembled onto the DNA origami through DNA hybridization. Due to the active targeting effect of the assembled aptamers, the multifunctional nanostructures achieved increased cellular internalization of DOX and AuNRs...
June 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/28580123/temporal-control-of-i-motif-switch-lifetimes-for-autonomous-operation-of-transient-dna-nanostructures
#17
L Heinen, A Walther
Functional DNA nanotechnology creates increasingly complex behaviors useful for sensing, actuation or computation, as enabled via the integration of dynamic and responsive structural DNA motifs. However, temporally controlled and dynamic DNA structures with programmable lifetimes, that are able to operate autonomously and self-revert to the starting state are challenging to achieve due to tedious and very system-specific sequence design. Here, we present a straightforward concept to program transient lifetimes into DNA duplexes based on the pH-sensitive DNA i-motif switch...
May 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28574712/tracking-single-dna-nanodevices-in-hierarchically-meso-macroporous-antimony-doped-tin-oxide-demonstrates-finite-confinement
#18
Daniel Mieritz, Xiang Li, Alex Volosin, Minghui Liu, Hao Yan, Nils G Walter, Dong-Kyun Seo
Housing bio-nano guest devices based on DNA nanostructures within porous, conducting, inorganic host materials promise valuable applications in solar energy conversion, chemical catalysis, and analyte sensing. Herein, we report a single-template synthetic development of hierarchically porous, transparent conductive metal oxide coatings whose pores are freely accessible by large biomacromolecules. Their hierarchal pore structure is bimodal with a larger number of closely packed open macropores (∼200 nm) at the higher rank and with the remaining space being filled with a gel network of antimony-doped tin oxide (ATO) nanoparticles that is highly porous with a broad size range of textual pores mainly from 20-100 nm at the lower rank...
June 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28574639/dna-origami-applications-in-cancer-therapy
#19
REVIEW
Anuttara Udomprasert, Thaned Kangsamaksin
Due to the complexity and heterogeneity of cancer, the development of cancer diagnosis and therapy is still progressing, and a complete understanding of cancer biology still remain elusive. Recently, cancer nanomedicine has gained much interest as promising diagnostic and therapeutic strategies as a wide range of nanomaterials possess unique physical properties that can render drug delivery systems more effective and safer. Also, targeted drug delivery and precision medicine have now become a new paradigm in cancer therapy...
June 2, 2017: Cancer Science
https://www.readbyqxmd.com/read/28570804/self-assembled-dna-dendrimer-nanoparticle-for-efficient-delivery-of-immunostimulatory-cpg-motifs
#20
Yijiao Qu, Juanjuan Yang, Pengfei Zhan, Shaoli Liu, Kun Zhang, Qiao Jiang, Can Li, Baoquan Ding
Dendrimer-like DNA nanostructures have attractive properties such as mechanical stability, highly branched nanostructure, customized sizes, and biocompatibility. In this study, we construct programmable DNA dendrimeric nanoparticles as efficient vehicles to deliver immunostimulatory cytosine-phosphate-guanosine (CpG) sequences for activation of the immune response. DNA dendrimers decorated with CpG-containing hairpin-loops triggered stronger immune response characterized by pro-inflammatory cytokines production, in contrast to DNA dendrimers loading linear CpG...
June 21, 2017: ACS Applied Materials & Interfaces
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