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https://www.readbyqxmd.com/read/30411048/core-shell-nanostructured-fe-3-o-4-poly-styrene-co-vinylbenzyl-chloride-grafted-ppi-dendrimers-stabilized-with-aunps-pdnps-for-efficient-nuclease-activity
#1
Eagambaram Murugan, Nimita Jebaranjitham J, Mathivathanan Ariraman, Saravanan Rajendran, Janankiraman Kathirvel, C R Akshata, Kalpana Kumar
Four different novel magnetic core-shell nanocomposites stabilized with Au/Pd nanoparticles (NPs) were prepared by a simple procedure and demonstrated their catalytic activity for effective cleavage of pBR322 DNA. Initially, the Fe3 O4 -poly(styrene-divinylbenzene-vinylbenzyl chloride) (ST-DVB-VBC) matrix functionalized with 3-aminobenzoic acid was prepared and grafted with PPI-G(2) and PPI-G(3) dendrimers. Each core-shell matrix was immobilized with AuNPs and PdNPs separately. The resulting composites were characterized by FT-IR, UV-vis, SEM, TEM, XRD, VSM, XPS, Raman, and TGA...
October 31, 2018: ACS Omega
https://www.readbyqxmd.com/read/30410972/dna-nanostructure-programmed-like-charge-attraction-at-the-cell-membrane-interface
#2
Hongming Ding, Jiang Li, Nan Chen, Xingjie Hu, Xiafeng Yang, Linjie Guo, Qian Li, Xiaolei Zuo, Lihua Wang, Yuqiang Ma, Chunhai Fan
Cell entry of anionic nano-objects has been observed in various types of viruses and self-assembled DNA nanostructures. Nevertheless, the physical mechanism underlying the internalization of these anionic particles across the negatively charged cell membrane remains poorly understood. Here, we report the use of virus-mimicking designer DNA nanostructures with near-atomic resolution to program "like-charge attraction" at the interface of cytoplasmic membranes. Single-particle tracking shows that cellular internalization of tetrahedral DNA nanostructures (TDNs) depends primarily on the lipid-raft-mediated pathway, where caveolin plays a key role in providing the short-range attraction at the membrane interface...
October 24, 2018: ACS Central Science
https://www.readbyqxmd.com/read/30410966/attack-on-the-cell-membrane-the-pointy-ends-of-dna-nanostructures-lead-the-way
#3
Pengfei Wang, Yonggang Ke
No abstract text is available yet for this article.
October 24, 2018: ACS Central Science
https://www.readbyqxmd.com/read/30410711/beyond-the-smiley-face-applications-of-structural-dna-nanotechnology
#4
REVIEW
Aakriti Alisha Arora, Chamaree de Silva
Since the development of DNA origami by Paul Rothemund in 2006, the field of structural DNA nanotechnology has undergone tremendous growth. Through DNA origami and related approaches, self-assembly of specified DNA sequences allows for the 'bottom-up' construction of diverse nanostructures. By utilizing different sets of small 'staple' DNA strands to direct the folding of a long scaffold strand in diverse ways, DNA origami has particularly been incorporated into a variety of prototypical applications beyond the two-dimensional (2D) smiley face...
2018: Nano Reviews & Experiments
https://www.readbyqxmd.com/read/30404153/pinpointed-stimulation-of-epha2-receptors-via-dna-templated-oligovalence
#5
Christin Möser, Jessica S Lorenz, Martin Sajfutdinow, David M Smith
DNA nanostructures enable the attachment of functional molecules to nearly any unique location on their underlying structure. Due to their single-base-pair structural resolution, several ligands can be spatially arranged and closely controlled according to the geometry of their desired target, resulting in optimized binding and/or signaling interactions. Here, the efficacy of SWL, an ephrin-mimicking peptide that binds specifically to EphrinA2 (EphA2) receptors, increased by presenting up to three of these peptides on small DNA nanostructures in an oligovalent manner...
November 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30398109/computational-and-experimental-binding-mechanism-ofdna-drug-interactions
#6
Chandrabose Selvaraj, Sanjeev Kumar Singh
Nucleic acid are the key unit and predominant genetic material for interpreting the fundamental basis of genetic information in an organism and now it's used for the evolution of a novel group of therapeutics. To identify the potential impact in the biological science, it receives high recognition in therapeutic applications.Due to their selective recognition of molecular targets and pathways, DNA significantly imparts tremendous specificity of action. With its high advantages in the assembly of device, interconnects and computational elements DNA has shown great potential fabrication and construction of nanostructures and devices...
November 5, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/30398084/ultrasonic-assisted-synthesis-and-dna-interaction-studies-of-two-new-ru-complexes-ruo-2-nanoparticles-preparation
#7
Jun-Jie Xue, Fahime Bigdeli, Jian-Ping Liu, Mao-Lin Hu, Ali Morsali
AIM: To study of the interactions of two new ruthenium(II) complexes (C1 and C2) with calf thymus (CT)-DNA; production of RuO2 nanoparticles using the complexes precursor. MATERIALS & METHODS: Complex C1 was characterized by x-ray crystallography. The binding of the complexes with (CT)-DNA was studied using techniques that include electronic absorption spectra, fluorescence and redox behavior. The preparation of RuO2 nanoparticles was carried out by thermal decomposition...
November 6, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30390600/high-performance-uv-photodetectors-using-nd-3-and-er-3-single-and-co-doped-dna-thin-films
#8
Srivithya Vellampatti, Maddaka Reddeppa, Sreekantha Reddy Dugasani, Sekhar Babu Mitta, Bramaramba Gnapareddy, Moon-Deock Kim, Sung Ha Park
Even though lanthanide ion (Ln3+ )-doped DNA nanostructures have been utilized in various applications, they are rarely employed for photovoltage generating devices because of difficulties in designing DNA-based devices that generate voltages under light illumination. Here, we constructed DNA lattices made of synthetic strands and DNA thin films extracted from salmon (SDNA) with single-doping of Nd3+ or Er3+ and co-doping of Nd3+ /Er3+ for high performance UV detection. The topological change of the DNA double-crossover (DX) lattices during the course of annealing was estimated from atomic force microscope (AFM) images to find the optimum concentration of Ln3+ ([Ln3+ ]O )...
October 24, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/30390006/uv-shielding-and-wavelength-conversion-by-centric-diatom-nanopatterned-frustules
#9
Edoardo De Tommasi, Roberta Congestri, Principia Dardano, Anna Chiara De Luca, Stefano Managò, Ilaria Rea, Mario De Stefano
Diatoms can represent the major component of phytoplankton and contribute massively to global primary production in the oceans. Over tens of millions of years they developed an intricate porous silica shell, the frustule, which ensures mechanical protection, sorting of nutrients from harmful agents, and optimization of light harvesting. Several groups of microalgae evolved different strategies of protection towards ultraviolet radiation (UVR), which is harmful for all living organisms mainly through the formation of dimeric photoproducts between adjacent pyrimidines in DNA...
November 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30389935/programming-molecular-topologies-from-single-stranded-nucleic-acids
#10
Xiaodong Qi, Fei Zhang, Zhaoming Su, Shuoxing Jiang, Dongran Han, Baoquan Ding, Yan Liu, Wah Chiu, Peng Yin, Hao Yan
Molecular knots represent one of the most extraordinary topological structures in biological polymers. Creating highly knotted nanostructures with well-defined and sophisticated geometries and topologies remains challenging. Here, we demonstrate a general strategy to design and construct highly knotted nucleic acid nanostructures, each weaved from a single-stranded DNA or RNA chain by hierarchical folding in a prescribed order. Sets of DNA and RNA knots of two- or three-dimensional shapes have been designed and constructed (ranging from 1700 to 7500 nucleotides), and they exhibit complex topological features, with high crossing numbers (from 9 up to 57)...
November 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/30376347/improving-the-enzymatic-stability-and-the-pharmacokinetics-of-oligonucleotides-via-dna-backboned-bottlebrush-polymers
#11
Fei Jia, Dali Wang, Xueguang Lu, Xuyu Tan, Yuyan Wang, Hao Lu, Ke Zhang
Herein, we design and synthesize site-specifically PEGylated oligonucleotide hairpins, and demonstrate that their ability to undergo hybridization chain reaction is nearly unaffected by the PEGylation. The resulting DNA-backboned bottlebrush polymers with PEG side chains exhibit increased resistance against nucleolytic degradation, enhanced thermal stabilities, and elevated blood retention times in vivo, which collectively pave the way for more therapeutically focused DNA nanostructure designs.
October 30, 2018: Nano Letters
https://www.readbyqxmd.com/read/30356926/tuning-the-coupling-in-single-molecule-heterostructures-dna-programmed-and-reconfigurable-carbon-nanotube-based-nanohybrids
#12
Mark Freeley, Antonio Attanzio, Alessandro Cecconello, Giuseppe Amoroso, Pierrick Clement, Gustavo Fernandez, Felice Gesuele, Matteo Palma
Herein a strategy is presented for the assembly of both static and stimuli-responsive single-molecule heterostructures, where the distance and electronic coupling between an individual functional nanomoiety and a carbon nanostructure are tuned via the use of DNA linkers. As proof of concept, the formation of 1:1 nanohybrids is controlled, where single quantum dots (QDs) are tethered to the ends of individual carbon nanotubes (CNTs) in solution with DNA interconnects of different lengths. Photoluminescence investigations-both in solution and at the single-hybrid level-demonstrate the electronic coupling between the two nanostructures; notably this is observed to progressively scale, with charge transfer becoming the dominant process as the linkers length is reduced...
October 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/30353636/integrating-dna-photonic-wires-into-light-harvesting-supramolecular-polymers-mariusz-kownacki-simon-m-langenegger-shi-xia-liu-and-robert-h%C3%A3-ner
#13
Robert Häner, Mariusz Kownacki, Simon M Langenegger, Shi-Xia Liu
An approach combining DNA nanoscaffolds with supramolecular polymers for the efficient and directional propagation of light-harvesting cascades has been developed. A series of photonic wires with different arrangements of fluorophores in DNA-organized nanostructures were linked to light-harvesting supramolecular phenanthrene polymers (SPs) in a self-assembled fashion. Among them, a light harvesting complex (LHC) composed of SPs and a photonic wire of phenanthrene, Cy3, Cy5 and Cy5.5 chromophores reveals a remarkable energy transfer efficiency of 59%...
October 24, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/30351920/amphiphilic-dna-platform-for-the-design-of-crystalline-frameworks-with-programmable-structure-and-functionality
#14
Ryan A Brady, Nicholas J Brooks, Vito Foderà, Pietro Cicuta, Lorenzo Di Michele
The reliable preparation of functional, ordered, nanostructured frameworks would be a game changer for many emerging technologies, from energy storage to nanomedicine. Underpinned by the excellent molecular recognition of nucleic acids, along with their facile synthesis and breadth of available functionalizations, DNA nanotechnology is widely acknowledged as a prime route for the rational design of nanostructured materials. Yet, the preparation of crystalline DNA frameworks with programmable structure and functionality remains a challenge...
November 2, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30350573/histone-mimetic-gold-nanoparticles-as-versatile-scaffolds-for-gene-transfer-and-chromatin-analysis
#15
Erik V Munsell, Bing Fang, Millicent O Sullivan
Histone-inspired polymer assemblies (polyplexes) can regulate gene expression and subcellular transport in plasmids by harnessing the cellular machinery normally used for histone proteins. When grafted to polyplexes, histone tails promote nuclear accumulation, trigger plasmid DNA (pDNA) release, and enhance transcription. Herein, we developed multifunctional gold nanoparticles (AuNPs) decorated by histone motifs as histone-inspired scaffolds with improved pDNA binding, easy bioimaging, and increased potential for gene delivery and chromatin analysis applications...
October 29, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/30348375/dna-nanostructures-from-palindromic-rolling-circle-amplification-for-the-fluorescent-detection-of-cancer-related-micrornas
#16
Huo Xu, Shuxin Zhang, Changhe Ouyang, Zhenmeng Wang, Dong Wu, Yiyun Liu, Yifan Jiang, Zai-Sheng Wu
Herein, DNA nanostructures were prepared via a palindromic padlock probe-based rolling circle amplification (called P-RCA) and then employed to implement the sensitive and specific detection of let-7a miRNA extracted from cancer cells without chemical modification. The presence of target let-7a miRNA as a polymerization primer can trigger the P-RCA process, generating a long tandemly repetitive DNA strand. The resulting products can fold into nanostructures via self-hybridization of palindromic regions and possess numerous double-stranded fragments...
January 15, 2019: Talanta
https://www.readbyqxmd.com/read/30342801/dna-nanocarriers-programmed-to-deliver
#17
REVIEW
Bharath Raj Madhanagopal, Shunqing Zhang, Esra Demirel, Heitham Wady, Arun Richard Chandrasekaran
Simple base-pairing rules of complementarity, perfected by evolution for encoding genetic information, provide unprecedented control over the process of DNA self-assembly. These rules allow us to build exquisite nanostructures and rationally design their morphology, fine-tune their chemical properties, and program their response to environmental stimuli. DNA nanostructures have emerged as promising candidates for transporting drugs across various physiological barriers of the body. In this review, we discuss the strategies used to transform DNA nanostructures into drug delivery vehicles...
October 17, 2018: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/30340689/electrochemical-quantitation-of-leishmania-infantum-based-on-detection-of-its-kdna-genome-and-transduction-of-non-spherical-gold-nanoparticles
#18
R Nazari-Vanani, N Sattarahmady, H Yadegari, N Delshadi, G R Hatam, H Heli
Detecting and monitoring the pathogens with high selectivity and sensitivity is critical for public health. In the present study, we demonstrated a specific analytical strategy for sensitive detection of Leishmania infantum genome. The developed sensor utilized toluidine blue as a hybridization indicator and a Leishmania infantum-specific capture DNA sequence immobilized on a high-surface area gold nanostructure as an electrochemical transducer. The produced analytical response was based on the hybridization of the single-stranded DNA from the target with the immobilized DNA sequence at the electrode surface...
December 24, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/30336059/graphene-encapsulated-dna-nanostructure-preservation-of-topographic-features-at-high-temperature-and-site-specific-oxidation-of-graphene
#19
Karen B Ricardo, Haitao Liu
This paper reports the effect of graphene encapsulation on the thermal stability of DNA nanostructures and the thermal oxidation of graphene in the presence of DNA nanostructures. Triangular-shaped DNA nanostructures were deposited onto a Si/SiO2 substrate and covered with single-layer graphene. The apparent height of the DNA nanostructure significantly decreased upon thermal annealing at 250 °C and higher temperatures. The topographical features of the DNA nanostructure, as measured by atomic force microscopy (AFM), disappeared after annealing at 300 °C for 5 h but reappeared after 23 h...
October 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/30335942/tetrahedral-dna-nanostructure-promote-endothelia-cells-proliferation-migration-and-angiogenesis-via-notch-signaling-pathway
#20
Dan Zhao, Mengting Liu, Qian-Shun Li, Xiaolin Zhang, Changyue Xue, Yun-Feng Lin, Xiaoxiao Cai
The problem of tissue vascularization is one of the obstacles that currently restrict the application of tissue engineering products to the clinic. Achieving tissue vascularization and providing adequate nutrients for tissues is an urgent problem to build complex and effective tissue-engineered tissues and organs. Therefore, the aim of this study was to investigate the effect of tetrahedral DNA nanostructures (TDNs), a novel and biocompatible nanomaterial, on angiogenesis. The results showed that TDNs can enter into endothelia cells (ECs) and promote ECs proliferation, migration, tube formation and the expressions of angiogenic growth factors at the concentration of 250nmol L-1, which was accompanied by activation of the Notch signaling pathway...
October 18, 2018: ACS Applied Materials & Interfaces
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