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https://www.readbyqxmd.com/read/29145168/frontal-infraslow-activity-marks-the-motor-spasms-of-anti-lgi1-encephalitis
#1
Richard Wennberg, Claude Steriade, Robert Chen, Danielle Andrade
OBJECTIVE: The clinical and electrographic features of seizures in anti-LGI1 encephalitis are distinct from those seen in other autoimmune encephalitides or non-encephalitic epilepsies. One electroclinical phenomenon specific to the condition consists of lateralized motor spasms, known as faciobrachial dystonic seizures (FBDS). An electrodecremental pattern overriding a "DC shift" has been described as the EEG correlate of these spasms. We sought to further characterize this pre-spasm infraslow activity (ISA)...
October 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29144430/a-correlation-study-of-dha-intake-estimated-by-a-ffq-and-concentrations-in-plasma-and-erythrocytes-in-mid-and-late-pregnancy
#2
Yu-Bo Zhou, Hong-Tian Li, Leonardo Trasande, Lin-Lin Wang, Ya-Li Zhang, Ke-Yi Si, Man-Xi Bai, Jian-Meng Liu
Adequate docosahexaenoic acid (DHA) is essential for the optimal growth and development of the fetus. Maternal DHA content fluctuates during pregnancy. The correlation of DHA content with dietary intake might be varied over the course of pregnancy. We aimed to compare the dietary DHA intake, estimated by a DHA-specific semiquantitative food frequency questionnaire (FFQ) against its blood content, among mid- and late-term pregnant women. A total of 804 Chinese pregnant women completed the tailored FFQ and provided fasting venous blood samples...
November 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29144027/longitudinal-change-in-adolescents-prosocial-behavior-toward-strangers-friends-and-family
#3
Laura M Padilla-Walker, Gustavo Carlo, Madison K Memmott-Elison
There is little understanding about how prosocial behavior toward different targets might change over time, and what might promote initial levels and age-related changes in prosocial behavior. Thus, this study examined longitudinal change in prosocial behavior toward strangers, friends, and family from early adolescence through the transition to adulthood. Participants included 500 adolescents from the United States (age 12 to age 20; 52% female, 65% European American). Latent growth curve models suggested that prosocial behavior toward strangers increased across early to mid-adolescence and then flattened out during the transition to adulthood, prosocial behavior toward friends increased steadily, and prosocial behavior toward family was relatively stable across adolescence and then increased...
November 16, 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29143877/ft-mir-and-nir-spectral-data-fusion-a-synergetic-strategy-for-the-geographical-traceability-of-panax-notoginseng
#4
Yun Li, Jin-Yu Zhang, Yuan-Zhong Wang
Three data fusion strategies (low-llevel, mid-llevel, and high-llevel) combined with a multivariate classification algorithm (random forest, RF) were applied to authenticate the geographical origins of Panax notoginseng collected from five regions of Yunnan province in China. In low-level fusion, the original data from two spectra (Fourier transform mid-IR spectrum and near-IR spectrum) were directly concatenated into a new matrix, which then was applied for the classification. Mid-level fusion was the strategy that inputted variables extracted from the spectral data into an RF classification model...
November 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29139168/hunter-gatherer-dental-pathology-do-historic-accounts-of-aboriginal-australians-correspond-to-the-archeological-record-of-dental-disease
#5
Judith Littleton
OBJECTIVES: Studies of hunter-gatherer oral pathology, particularly in Australia, often focus upon dental wear and caries or assume that historic studies of Aboriginal people reflect the precontact past. Consequently the range of population variation has been underestimated. In this paper dental pathology from human remains from Roonka are compared with a model of dental pathology derived from historic studies. The aim is to identify aspects of dental pathology indicative of regional or intra-population diversity...
November 15, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29138920/concurrent-arthroscopic-osteochondral-lesion-treatment-and-lateral-ankle-ligament-repair-has-no-substantial-effect-on-the-outcome-of-chronic-lateral-ankle-instability
#6
Dong Jiang, Yin-Fang Ao, Chen Jiao, Xing Xie, Lin-Xin Chen, Qin-Wei Guo, Yue-Lin Hu
PURPOSE: The purpose of the study was to evaluate the effect of concurrent arthroscopic osteochondral lesion (OCL) treatment and lateral ankle ligament repair on the outcome of chronic lateral ankle instability. It was hypothesized that the arthroscopic OCL treatment might have some negative effect on the outcome of chronic lateral ankle instability (CLAI) by compromising the rehabilitation program. METHODS: Ankle arthroscopy and anatomic lateral ankle ligament repair with suture anchors were performed for 70 patients with CLAI between 2010 and 2012...
November 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29138135/comparative-clinical-effectiveness-and-cost-effectiveness-of-endovascular-strategy-v-open-repair-for-ruptured-abdominal-aortic-aneurysm-three-year-results-of-the-improve-randomised-trial
#7
(no author information available yet)
Objective To assess the three year clinical outcomes and cost effectiveness of a strategy of endovascular repair (if aortic morphology is suitable, open repair if not) versus open repair for patients with suspected ruptured abdominal aortic aneurysm.Design Randomised controlled trial.Setting 30 vascular centres (29 in UK, one in Canada), 2009-16.Participants 613 eligible patients (480 men) with a clinical diagnosis of ruptured aneurysm, of whom 502 underwent emergency repair for rupture.Interventions 316 patients were randomised to an endovascular strategy (275 with confirmed rupture) and 297 to open repair (261 with confirmed rupture)...
November 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29137819/vascular-response-and-healing-profile-of-everolimus-eluting-bioresorbable-vascular-scaffolds-for-percutaneous-treatment-of-chronic-total-coronary-occlusions-a-one-year-optical-coherence-tomography-analysis-from-the-ghost-cto-registry
#8
Alessio La Manna, Eligio Miccichè, Guido D'Agosta, Gabriel Tensol Rodrigues Pereira, Guilherme Ferragut Attizzani, Piera Capranzano, Davide Capodanno, Corrado Tamburino
BACKGROUND: Bioresorbable vascular scaffolds (BVS) have been heralded with potential benefits that are especially desired in long lesions, including chronic total occlusions (CTOs). Procedural feasibility and mid-term outcomes of BVS in CTOs have been reported. However, there is still a paucity of data regarding the vascular and healing response to BVS in CTOs evaluated by optical coherence tomography (OCT). METHODS: This study included prospectively 21 patients who had a CTO lesion treated with a BVS...
November 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29137670/modelling-and-mapping-tick-dynamics-using-volunteered-observations
#9
Irene Garcia-Martí, Raúl Zurita-Milla, Arnold J H van Vliet, Willem Takken
BACKGROUND: Tick populations and tick-borne infections have steadily increased since the mid-1990s posing an ever-increasing risk to public health. Yet, modelling tick dynamics remains challenging because of the lack of data and knowledge on this complex phenomenon. Here we present an approach to model and map tick dynamics using volunteered data. This approach is illustrated with 9 years of data collected by a group of trained volunteers who sampled active questing ticks (AQT) on a monthly basis and for 15 locations in the Netherlands...
November 14, 2017: International Journal of Health Geographics
https://www.readbyqxmd.com/read/29136901/biomarker-analysis-of-hemoglobin-adducts-of-acrylamide-and-glycidamide-enantiomers-for-mid-term-internal-exposure-assessment-by-isotope-dilution-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#10
Yu Zhang, Qiao Wang, Gong Zhang, Wei Jia, Yiping Ren, Yongning Wu
Hemoglobin (Hb) adducts of acrylamide (AA) and its oxidative metabolite glycidamide (GA) are important biomarkers for evaluating the mid-term exposure of acrylamide toxicity in vivo. Taking pentafluoro-2-methylphenyl isothiocyanates of N-(2-carbamoylethyl)valine (AAVal-PFPTH) and N-(2-carbamoyl-2-hydroxyethy)valine (GAVal-PFPTH) as target analytes, we developed an isotope dilution ultra-high performance liquid chromatograph tandem mass spectrometry (UHPLC-MS/MS) method for the simultaneous determination of AA and GA hemoglobin (Hb) adducts under the electroscopy ionization negative (ESI‾) mode in the present work...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29135983/arginase-expression-modulates-nitric-oxide-production-in-leishmania-leishmania-amazonensis
#11
Stephanie Maia Acuña, Juliana Ide Aoki, Maria Fernanda Laranjeira-Silva, Ricardo Andrade Zampieri, Juliane Cristina Ribeiro Fernandes, Sandra Marcia Muxel, Lucile Maria Floeter-Winter
BACKGROUND: Arginase is an enzyme that converts L-arginine to urea and L-ornithine, an essential substrate for the polyamine pathway supporting Leishmania (Leishmania) amazonensis replication and its survival in the mammalian host. L-arginine is also the substrate of macrophage nitric oxide synthase 2 (NOS2) to produce nitric oxide (NO) that kills the parasite. This competition can define the fate of Leishmania infection. METHODOLOGY/PRINCIPAL FINDINGS: The transcriptomic profiling identified a family of oxidoreductases in L...
2017: PloS One
https://www.readbyqxmd.com/read/29135907/efavirenz-therapeutic-range-in-hiv-1-treatment-naive-participants
#12
Cindy J Bednasz, Charles S Venuto, Qing Ma, Eric S Daar, Paul E Sax, Margaret A Fischl, Ann C Collier, Kimberly Y Smith, Camlin Tierney, Yang Yang, Gregory E Wilding, Gene D Morse
BACKGROUND: Efavirenz is currently suggested as an alternative to recommended antiretroviral (ARV) regimens by the Department of Health and Human Services for the treatment of HIV-1 in ARV-naive patients. A mid-dosing interval therapeutic range between 1000 and 4000 ng/mL for efavirenz has been proposed in the literature, with patients more likely to experience virologic failure below this range and adverse effects above. The current study reports an analysis of virologic outcome between those above, below, or within the reported efavirenz therapeutic range (1000-4000 ng/mL) and within subgroups...
December 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29134050/mental-strategies-predict-performance-and-satisfaction-with-performance-among-soccer-players
#13
Magdalena Kruk, Jan Blecharz, Monika Boberska, Karolina Zarychta, Aleksandra Luszczynska
This study investigated the changes in mental strategies across the season and their effects on performance and satisfaction with individual performance. Data were collected three times: at the pre-season at Time 1 (T1; baseline), in the mid-season at Time 2 (T2; two-month follow-up), and at the end-of-season at Time 3 (T3; nine-month follow-up) among male soccer players (N = 97) aged 16-27. Athletes completed the questionnaires assessing the use of nine psychological strategies in competition and the level of satisfaction with individual performance...
October 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29133110/provision-of-medical-abortion-by-mid-level-healthcare-providers-in-kyrgyzstan-testing-an-intervention-to-expand-safe-abortion-services-to-under-served-rural-and-peri-urban-areas
#14
Brooke Ronald Johnson, Elmira Maksutova, Aigull Boobekova, Ainura Davletova, Chinara Kazakbaeva, Yelena Kondrateva, Sihem Landoulsi, Gunta Lazdane, Kubanychbek Monolbaev, Armando H Seuc Jo
OBJECTIVE: To demonstrate the feasibility and safety of training mid-level healthcare providers (midwives and family nurses) to provide medical abortion and post-abortion contraception in under-served areas in Kyrgyzstan. STUDY DESIGN: This was an implementation study at four referral facilities and 28 Felsher Obstetric Points in two districts to train their midwives and family nurses to deliver safe and effective abortion care with co-packaged mifepristone-misoprostol and provide contraceptives post-abortion...
November 10, 2017: Contraception
https://www.readbyqxmd.com/read/29132346/less-healthy-breakfast-cereals-are-promoted-more-frequently-in-large-supermarket-chains-in-canada
#15
Monique Potvin Kent, Erika Rudnicki, Crystal Usher
BACKGROUND: The majority of food expenditures are made in supermarkets and this environment influences our purchasing and food intake. Breakfast cereals are frequently marketed as healthy food choices. The objective of this study was to examine the frequency of in-store promotions for cold breakfast cereals in Canadian supermarkets and to determine whether healthier or less healthy breakfast cereals are promoted more frequently. METHODS: Data was collected once per week over a four-week period from a convenience sample of the five largest Canadian supermarkets in the Ottawa/Gatineau area...
November 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29132336/study-protocol-the-labor-progression-study-laps-does-the-use-of-a-dynamic-progression-guideline-in-labor-reduce-the-rate-of-intrapartum-cesarean-sections-in-nulliparous-women-a-multicenter-cluster-randomized-trial-in-norway
#16
Stine Bernitz, Rebecka Dalbye, Pål Øian, Jun Zhang, Torbjørn Moe Eggebø, Ellen Blix
BACKGROUND: The increasing rate of intrapartum cesarean sections is subject of attention and concern as it is associated with adverse outcomes. Labor dystocia is one of the most frequent indications for cesarean sections even though there is no consensus on criteria for labor dystocia. Traditionally the progression of labor follows guidelines based on Friedman's curve from the mid 1950s. In 2010 Zhang presented a new labor curve and a dynamic guideline for labor progression based on contemporary research...
November 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29130706/androgen-receptor-gene-polymorphisms-and-maximal-fat-oxidation-in-healthy-men-a-longitudinal-study
#17
Jesús Gustavo Ponce González, Amelia Guadalupe-Grau, Francisco Germán Rodríguez-González, Rafael Torres-Peralta, David Morales-Alamo, Lorena Rodríguez-García, Bonifacio Nicolás Díaz-Chico, José Antonio López Calbet, Cecilia Dorado
INTRODUCTION: Androgens play a major role in fat oxidation; however, the effects of androgens depend, among other factors, on the intrinsic characteristics of the androgen receptor (AR). Lower repetitions of CAG and GGN polymorphism appear to have a protective effect on fat accumulation in the transition from adolescent to mid-twenties. Whether a similar protective effect is present later in life remains unknown. The aims of this study were: a) to evaluate if extreme CAG and GGN repeat polymorphisms of the androgen receptors influence body fat mass, its regional distribution, resting metabolic rate (RMR), maximal fat oxidation capacity (MFO) and serum leptin, free testosterone and osteocalcin in healthy adult men; and b) to determine the longitudinal effects on fat tissue accumulation after 6...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29129997/trichloroethylene-induced-alterations-in-dna-methylation-were-enriched-in-polycomb-protein-binding-sites-in-effector-memory-cd4-t-cells
#18
Kathleen M Gilbert, Sarah J Blossom, Brad Reisfeld, Stephen W Erickson, Kanan Vyas, Mary Maher, Brannon Broadfoot, Kirk West, Shasha Bai, Craig A Cooney, Sudeepa Bhattacharyya
Exposure to industrial solvent and water pollutant trichloroethylene (TCE) can promote autoimmunity, and expand effector/memory (CD62L) CD4(+) T cells. In order to better understand etiology reduced representation bisulfite sequencing was used to study how a 40-week exposure to TCE in drinking water altered methylation of ∼337 770 CpG sites across the entire genome of effector/memory CD4(+) T cells from MRL+/+ mice. Regardless of TCE exposure, 62% of CpG sites in autosomal chromosomes were hypomethylated (0-15% methylation), and 25% were hypermethylated (85-100% methylation)...
July 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29129614/mid-term-clinical-functional-and-radiographic-outcomes-of-105-gender-specific-patellofemoral-arthroplasties-with-or-without-the-association-of-medial-unicompartmental-knee-arthroplasty
#19
Sergio Romagnoli, Matteo Marullo
BACKGROUND: The purpose of this study is to evaluate clinical and radiographic outcomes after gender-specific patellofemoral arthroplasty (PFA) either isolated or combined with unicompartmental knee arthroplasty (UKA). METHODS: A total of 105 PFAs in 85 patients were reviewed: 64 knees had isolated patellofemoral osteoarthritis and received an isolated PFA, and 41 knees with bicompartmental osteoarthritis were treated with medial UKA and PFA. Preoperative and postoperative clinical and functional assessment included knee range of motion, Knee Society Score, University of California Los Angeles Activity Score, Tegner Activity Level Scale, and visual analogue scale pain...
October 24, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29129374/the-jarvik-2000-left-ventricular-assist-device-as-a-bridge-to-transplantation-japanese-registry-for-mechanically-assisted-circulatory-support
#20
Hiroki Kohno, Goro Matsumiya, Yoshiki Sawa, Minoru Ono, Yoshikatsu Saiki, Akira Shiose, Kenji Yamazaki, Yoshiro Matsui, Hiroshi Niinami, Hikaru Matsuda, Soichiro Kitamura, Takeshi Nakatani, Shunei Kyo
BACKGROUND: The Jarvik 2000 ventricular assist device features a miniaturized intraventricular pump and an intermittent low-speed function that facilitates aortic valve opening. Despite its long history, little is known about the Jarvik device with regard to post-implantation outcomes. METHODS: Prospectively collected data from 13 participating hospitals were extracted from the Japanese Registry for Mechanically Assisted Circulatory Support database to analyze mortality, morbidity and de-novo aortic regurgitation...
October 24, 2017: Journal of Heart and Lung Transplantation
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