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acute liver disease

Rodrigo Bronze de Martino, Edson Abdala, Felipe Castro Villegas, Luiz Augusto Carneiro D'Albuquerque, Alice Tung Wan Song
OBJECTIVES: Patients receiving treatment for tuberculosis are at risk of developing acute liver failure due to the hepatotoxicity of antitubercular drugs. We aimed to describe our experience with liver transplantation from deceased donors in this situation. METHODS: We identified patients undergoing transplantation for acute liver failure due to antitubercular drugs in our prospectively maintained database. RESULTS: Of 81 patients undergoing transplantation for acute liver failure, 8 cases were attributed to antitubercular drugs during the period of 2006-2016...
July 16, 2018: Clinics
Claudio Augusto Marroni, Alfeu Medeiros Fleck, Sabrina Alves Fernandes, Lucas Homercher Galant, Marcos Mucenic, Mario Henrique de Mattos Meine, Guilherme Mariante-Neto, Ajacio Bandeira de Mello Brandão
Alcohol consumption accounts for 3.8% of annual global mortality worldwide, and the majority of these deaths are due to alcoholic liver disease (ALD), mainly alcoholic cirrhosis. ALD is one of the most common indications for liver transplantation (LT). However, it remains a complicated topic on both medical and ethical grounds, as it is seen by many as a "self-inflicted disease". One of the strongest ethical arguments against LT for ALD is the probability of relapse. However, ALD remains a common indication for LT worldwide...
July 14, 2018: World Journal of Gastroenterology: WJG
Jan Pitha
No abstract text is available yet for this article.
July 6, 2018: International Journal of Cardiology
Peng Chen, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang, Xiao-Ping Chen
BACKGROUNDS: UDP-glucuronosyltransferase 1A subfamily (UGT1A) enzymes can inactivate cytarabine (Ara-C) by glucuronidation, and thus serves as candidate genes for interindividual difference in Ara-C response. UGT1A1 is a major UGT1A isoform expressed in human liver. METHODS: UGT1A1*6 and *28 polymorphisms resulting in reduced UGT1A1 activity were genotyped in 726 adult acute myeloid leukemia (AML) patients treated with Ara-C based regimens. Influences of both polymorphisms on chemosensitivity and disease prognosis of the patients were evaluated...
July 17, 2018: Journal of Translational Medicine
Ran Xue, Qinghua Meng, Juan Li, Jing Wu, Qinwei Yao, Hongwei Yu, Yueke Zhu
Acute-on-chronic liver failure (ACLF) is a serious life-threatening disease with high prevalence. Liver transplantation is the only efficient clinical treatment for ACLF. Because of the rapid progression and lack of liver donors, it is urgent to find an effective and safe therapeutic approach to ACLF. Recent studies showed that multipotent cell transplantation could improve the patients' liver function and enhance their preoperative condition. Cells such as mesenchymal stem cells, bone marrow mononuclear cells and autologous peripheral blood stem cells, which addressed in this study have all been used in multipotent cell transplantation for liver diseases...
June 23, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
Estefanía Rossetti, Anabella Boto, Carlos González Cambaceres, Silvina Ruvinsky, Ezequiel Sagray
Hydatidosis is a parasitic infection caused by the Echinococcus granulosus larvae, transmitted by the ingestion of infected food, characterized by the formation of cysts in vital organs. In Argentina, the disease is spread throughout the territory, constituting an important public health issue. The disease usually affects the liver and lungs. The affection of other organs is rare, and even more uncommon the affection of the heart. We present the case of a disseminated hydatidosis in a pediatric patient, whose initial clinical manifestation was an acute arterial embolism of the right limb caused by the rupture of a hydatidic cardiac cyst...
August 1, 2018: Archivos Argentinos de Pediatría
Francesca Cingolani, Mark J Czaja
Overactivation of the innate immune response amplifies hepatic injury and promotes the progression to fibrosis and cirrhosis in many liver diseases. Hepatic and systemic inflammation are triggered in part by factors released from dying hepatocytes, but recent evidence demonstrates that increased inflammation occurs in end-stage cirrhotic liver disease which typically has low levels of hepatocyte injury.(1) Clinical decompensation in patients with cirrhosis is associated with increased inflammation which is even greater in patients with acute-on-chronic liver failure (ACLF)...
July 16, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Ling Yuan, Lv Zhu, Yumei Zhang, Huan Chen, Hongxin Kang, Juan Li, Xianlin Zhao, Meihua Wan, Yifan Miao, Wenfu Tang
Background: The traditional Chinese formula Da-Cheng-Qi-decoction (DCQD) has been used to treat acute pancreatitis for decades. DCQD could ameliorate the disease severity and the complications of organ injuries, including those of the liver and lungs. However, the pharmacological effects in the kidney, a target organ, are still unclear. This study aimed to investigate the herbal tissue pharmacology of DCQD for acute kidney injury (AKI) in rats with severe acute pancreatitis (SAP). Methods: Rats were randomly divided into the sham-operation group (SG), the model group (MG) and the low-, medium- and high-dose treatment groups (LDG, MDG, and HDG, respectively)...
2018: Chinese Medicine
Chen Li, H Su, J Hu, H Duan, J Ji
Hepatitis A virus (HAV) is a major cause of acute viral hepatitis, which can lead to severe cases and acute liver failure. A 41-year-old Chinese military officer of the United Nations peacekeeping forces in South Sudan manifested fever, jaundice and coagulation dysfunction. The patient initially had a negative anti-HAV IgM antibody test result but a positive anti-HAV-IgM antibody test result five days after his alanine aminotransferase (ALT) levels peaked. He was given telemedicine consultation and was transferred to a Chinese military hospital specialising in infectious diseases for treatment of severe acute HAV infection...
July 15, 2018: Journal of the Royal Army Medical Corps
Jolanta Majka, Mateusz Wierdak, Iwona Brzozowska, Marcin Magierowski, Aleksandra Szlachcic, Dagmara Wojcik, Slawomir Kwiecien, Katarzyna Magierowska, Jacek Zagajewski, Tomasz Brzozowski
Melatonin is a tryptophan-derived molecule with pleiotropic activities which is produced in all living organisms. This "sleep" hormone is a free radical scavenger, which activates several anti-oxidative enzymes and mechanisms. Melatonin, a highly lipophilic hormone, can reach body target cells rapidly, acting as the circadian signal to alter numerous physiological functions in the body. This indoleamine can protect the organs against a variety of damaging agents via multiple signaling. This review focused on the role played by melatonin in the mechanism of esophagoprotection, starting with its short-term protection against acute reflux esophagitis and then investigating the long-term prevention of chronic inflammation that leads to gastroesophageal reflux disease (GERD) and Barrett's esophagus...
July 13, 2018: International Journal of Molecular Sciences
Chris Chan, Monika Mukerji
Acute pancreatitis is rare but well documented in pregnancy and most cases are attributable to biliary disease. We present a case of acute non-gallstone pancreatitis in a patient with acute and severe pre-eclampsia. A 39-year-old primigravida woman at 33 + 4 weeks' dichorionic diamniotic gestation presented with severe bilateral lower-limb oedema and underwent an emergency caesarean section due to the development of acute severe pre-eclampsia. Postpartum, the woman developed out-of-proportion generalised upper abdominal tenderness with worsening liver function and markedly raised lipase and amylase levels...
July 2018: Case Reports in Women's Health
Yun Sun, Yankai Wen, Chanjuan Shen, Yuanrun Zhu, Wendong You, Yuanyuan Meng, Lijuan Chen, Yiping Feng, Xiaofeng Yang, Zuo-Bing Chen
Hyperbaric oxygen therapy (HBOT) is an efficient therapeutic option to improve progress of lots of diseases especially hypoxia-related injuries, and has been clinically established as a wide-used therapy for patients with carbon monoxide poisoning, decompression sickness, arterial gas embolism, problematic wound, and so on. In the liver, most studies positively evaluated HBOT as a potential therapeutic option for liver transplantation, acute liver injury, nonalcoholic steatohepatitis, fibrosis and cancer, especially for hepatic artery thrombosis...
2018: International Journal of Medical Sciences
N Eisenberg, I Gockel, N von Dercks
BACKGROUND: The registration of diagnoses and diagnose-related groups (DRG) allows conclusions to be drawn about the distribution over the course of the year. Seasonal variations can be recognized and used to plan further resource management. METHODS: From 2006 to 2016 a total of 30,999 main diagnoses and DRGs were registered at the hospital for visceral surgery of the University Medical Hospital in Leipzig. The data were sorted on a monthly and seasonal basis and compared to meteorological data received from the German Meteorological Service...
July 13, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Ammar Hassan, Robert J Fontana
Drug induced liver injury (DILI) is an uncommon but important cause of liver disease that can arise after exposure to a multitude of drugs and herbal and dietary supplements. The severity of idiosyncratic DILI varies from mild serum aminotransferase elevations to the development of severe liver injury that can progress to acute liver failure resulting in death or liver transplantation within days of DILI onset. Chronic liver injury that persists for more than 6 months after DILI onset is also becoming increasingly recognized in up to 20% of DILI patients...
July 13, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
May Basood, Howard S Oster, Moshe Mittelman
The myelodysplastic syndromes (MDS) are a group of clonal bone marrow (BM) stem cell disorders, characterized by ineffective hematopoiesis, peripheral cytopenias, and hematologic cellular dysfunction, as well as potential transformation to acute leukemia. Thrombocytopenia is common in MDS and is associated with bleeding complications, occasionally life-threatening. Low platelet count (PLT), as well declining PLT also serves as a prognostic marker. Understanding thrombopoiesis led to the cloning of thrombopoietin, resulting in the development of platelet stimulating agents, thrombomimetics, romiplostim and eltrombopag...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Rebecca E Schultze-Florey, Sabine Tischer, Leonie Kuhlmann, Patrick Hundsdoerfer, Arend Koch, Ioannis Anagnostopoulos, Sarina Ravens, Lilia Goudeva, Christian Schultze-Florey, Christian Koenecke, Rainer Blasczyk, Ulrike Koehl, Hans-Gert Heuft, Immo Prinz, Britta Eiz-Vesper, Britta Maecker-Kolhoff
Epstein-Barr virus (EBV)-associated posttransplant lymphoproliferative disease (PTLD) with central nervous system (CNS) involvement is a severe complication after solid organ transplantation. Standard treatment with reduction of immunosuppression and anti-CD20 antibody application often fails leading to poor outcome. Here, we report the case of an 11-year-old boy with multilocular EBV-positive CNS PTLD 10 years after liver transplantation. Complete remission was achieved by repeated intravenous and intrathecal anti-CD20 antibody rituximab administration combined with intrathecal chemotherapy (methotrexate, cytarabine, prednisone) over a time period of 3 months...
2018: Frontiers in Immunology
Ignacio Estrada León, Ana Guiberteau Sánchez, Gema Vinagre Rodríguez, Gerardo Blanco Fernández, Demetrio Pérez Civantos, María Jesús Gaspar Blázquez, Isidoro Narváez Rodríguez
No abstract text is available yet for this article.
July 8, 2018: Gastroenterología y Hepatología
Christina C Lindenmeyer, Ahyoung Kim, Vedha Sanghi, Rocio Lopez, Fadi Niyazi, Neal A Mehta, Gianina Flocco, Aanchal Kapoor, William D Carey, Carlos Romero-Marrero
PURPOSE: Needs, risks, and outcomes of patients admitted to a post liver transplant intensive care unit (POLTICU) differ in important ways from those admitted to pretransplant intensive care units (ICUs). The aim of this study was to create the optimal model to risk stratify POLTICU patients. METHODS: Consecutive patients who underwent first deceased donor liver transplantation (LT) at a large United States center between 2008 and 2014 were followed from admission to LT and to discharge or death...
January 1, 2018: Journal of Intensive Care Medicine
Ewa Woźnica, Lidia Łysenko
Serum procalcitonin (PCT) is a sensitive biomarker used for the diagnosis of infection and sepsis. PCT has also some toxic effects. It is not a proinflammatory stimulus, but may augment the inflammatory processes. High levels of PCT in sepsis may lead to hepatocyte necrosis and, as a result, to liver failure. The pathomechanism of the toxic effect of PCT is still unknown. The influence of liver function on PCT levels has not been studied yet. It is not sure whether the liver dysfunction affects the diagnostic and prognostic value of serum PCT levels...
July 11, 2018: Anaesthesiology Intensive Therapy
Peng Lan, Shuo-Jia Wang, Qiu-Cheng Shi, Ying Fu, Qing-Ye Xu, Tao Chen, Yun-Xian Yu, Kong-Han Pan, Ling Lin, Jian-Cang Zhou, Yun-Song Yu
Cirrhotic patients with infection are prone to develop sepsis or even septic shock rendering poorer prognosis. However, few methods are available to predict the prognosis of cirrhotic patients with infection although there are some scoring systems can be used to predict general patients with cirrhosis. Therefore, we aimed to explore the predictive value of scoring systems in determining the outcome of critically ill cirrhotic patients with suspected infection.This was a retrospective cohort study based on a single-center database...
July 2018: Medicine (Baltimore)
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